elemental bromine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	elemental bromine	go back to main search page
Accession:	CHEBI:36894	browse the term

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Genes (156)

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1A

decreases activity

thiazolyl blue results in decreased activity of ABCB1 protein

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

aconitase 2, mitochondrial

multiple interactions

[Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

caspase 3

increases activity

thiazolyl blue results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity

thiazolyl blue results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

N-ribosyldihydronicotinamide quinone reductase 2

multiple interactions
increases reduction

resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]

NCBI chr13:34,148,642...34,172,448
Ensembl chr13:34,148,670...34,172,426

butylscopolamine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

dibromine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

multiple interactions

Bromine results in decreased activity of and results in increased metabolism of ATP2A2 protein

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

cystic fibrosis transmembrane conductance regulator

decreases activity

Bromine results in decreased activity of CFTR protein

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

cytochrome b-245, beta polypeptide

increases expression

Bromine results in increased expression of CYBB protein

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

natriuretic peptide type B

increases cleavage

Bromine results in increased cleavage of NPPB protein

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

phospholamban

decreases phosphorylation

Bromine results in decreased phosphorylation of PLN protein

NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083

G

protein phosphatase with EF hand calcium-binding domain 1

increases expression

Bromine results in increased expression of PPEF1 protein

NCBI chr X:159,404,997...159,534,286
Ensembl chr X:159,406,090...159,518,761

G

troponin I, cardiac 3

increases expression

Bromine results in increased expression of TNNI3 protein

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

NAN 190 hydrobromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine (serotonin) receptor 1A

multiple interactions

[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine

PMID:15213358 PMID:15482641 PMID:16528294

NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630

pifithrin-alpha hydrobromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenomedullin

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA]

NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027

G

angiotensinogen

multiple interactions

pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

aryl-hydrocarbon receptor

affects localization
multiple interactions

pifithrin affects the localization of AHR protein
pifithrin binds to and results in increased activity of AHR protein

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

apoptosis-inducing factor, mitochondrion-associated 1

multiple interactions

pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein]

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

thymoma viral proto-oncogene 1

multiple interactions

[Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein

PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

apoptotic peptidase activating factor 1

increases expression

pifithrin results in increased expression of APAF1 protein

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

amyloid beta precursor protein

multiple interactions

pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

activating transcription factor 3

multiple interactions

pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA]

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

ataxia telangiectasia mutated

multiple interactions

pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

RIKEN cDNA B230217C12 gene

decreases expression

pifithrin results in decreased expression of LASP1NB mRNA

NCBI chr11:97,731,961...97,734,263
Ensembl chr11:97,731,606...97,734,925

G

BCL2-antagonist/killer 1

multiple interactions

pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein]

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
decreases expression

pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein]
pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]
pifithrin results in decreased expression of BAX protein

PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCL2 binding component 3

decreases expression
multiple interactions

pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein
pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]

PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 More...

NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130

G

B cell leukemia/lymphoma 2

multiple interactions

pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein]

PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions

[Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]]
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]

PMID:15987750 PMID:21593185 PMID:30009776

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BH3 interacting domain death agonist

multiple interactions

pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein]

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

baculoviral IAP repeat-containing 5

multiple interactions

[Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein]

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

breast cancer 1, early onset

multiple interactions

pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

BUB1B, mitotic checkpoint serine/threonine kinase

multiple interactions

pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]

NCBI chr 2:118,428,684...118,472,073
Ensembl chr 2:118,428,692...118,472,072

G

complement component 3

multiple interactions

pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein]

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

caspase 12

multiple interactions

pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein]

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 2

multiple interactions

pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein]

PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371

NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442

G

caspase 3

multiple interactions
increases cleavage
decreases expression
decreases activity

pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein]
[pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]
pifithrin results in increased cleavage of CASP3 protein
pifithrin results in decreased expression of CASP3 protein
pifithrin results in decreased activity of CASP3 protein
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]

PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions

pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]
pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]

PMID:24704558 PMID:26259609

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

multiple interactions

pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]

PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]

PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 More...

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cyclin B1

increases expression
multiple interactions

pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein
[pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein

PMID:16620711 PMID:18516295

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin G1

multiple interactions

pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA]

NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138

G

cyclin G2

multiple interactions

[pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA

NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090

G

cell division cycle 25A

multiple interactions

pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA]

NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963

G

cell division cycle 25C

multiple interactions

[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cadherin 1

multiple interactions
decreases expression

pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]
pifithrin results in decreased expression of CDH1 protein

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

cyclin dependent kinase 1

multiple interactions
increases expression
increases phosphorylation

[pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein
pifithrin results in increased expression of CDK1 protein
pifithrin results in increased phosphorylation of CDK1 protein

PMID:16620711 PMID:18516295

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 2

multiple interactions

pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein]

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases expression

pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
pifithrin results in decreased expression of CDKN1A protein
pifithrin results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]

PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 More...

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

checkpoint kinase 2

multiple interactions

pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]

NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

multiple interactions

pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]

NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422

G

CREB binding protein

multiple interactions

pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein]

NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861

G

C-X-C motif chemokine receptor 4

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA]

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome c, somatic

multiple interactions

pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein
pifithrin results in decreased activity of CYP1A1 protein

PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases activity

pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein
pifithrin results in decreased activity of CYP1A2 protein

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
decreases activity
multiple interactions

pifithrin results in increased expression of CYP1B1 mRNA
pifithrin results in decreased activity of CYP1B1 protein
pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]

PMID:16258175 PMID:35908932

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

damage specific DNA binding protein 2

multiple interactions

pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA]

PMID:20064835 PMID:27694624

NCBI chr 2:91,041,924...91,067,465
Ensembl chr 2:91,041,917...91,067,327

G

dual specificity phosphatase 1

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA]

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

endothelin 1

decreases expression
multiple interactions

pifithrin results in decreased expression of EDN1 mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

endothelin receptor type B

decreases expression

pifithrin results in decreased expression of EDNRB mRNA

NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838

G

Fas cell surface death receptor

multiple interactions

pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein]
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein]

PMID:11779855 PMID:16687611 PMID:26451628

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

ferredoxin reductase

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA]

NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876

G

FBJ osteosarcoma oncogene B

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]

NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976

G

ferritin heavy polypeptide 1

multiple interactions

pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein]

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

growth arrest and DNA-damage-inducible 45 alpha

multiple interactions

pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA]

PMID:20064835 PMID:20955365

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

growth differentiation factor 15

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA]

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

galactosidase, beta 1

multiple interactions

pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein]

NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966

G

glutathione peroxidase 4

multiple interactions

pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein]

NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273

G

H2A.X variant histone

multiple interactions

pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]
[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein]

PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

hemolytic complement

multiple interactions

pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein]

NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450

G

inhibitor of kappaB kinase beta

increases phosphorylation
multiple interactions

pifithrin results in increased phosphorylation of IKBKB protein
pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]

NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605

G

jun proto-oncogene

increases expression

pifithrin results in increased expression of JUN protein

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression

pifithrin results in decreased expression of KIT mRNA

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

kit ligand

decreases expression
multiple interactions

pifithrin results in decreased expression of KITLG mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

LIM and SH3 protein 1

increases expression

pifithrin results in increased expression of LASP1 mRNA

NCBI chr11:97,689,748...97,729,591
Ensembl chr11:97,689,826...97,729,590

G

lactate dehydrogenase A

multiple interactions

pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein]

NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051

G

lysozyme 2

multiple interactions

pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA]

NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226

G

mitogen-activated protein kinase 1

multiple interactions
increases expression
increases phosphorylation

pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]
pifithrin results in increased expression of MAPK1 protein modified form
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]

PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 10

multiple interactions

pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein]

NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200

G

mitogen-activated protein kinase 14

multiple interactions
increases phosphorylation

pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein]
pifithrin results in increased phosphorylation of MAPK14 protein

PMID:16005925 PMID:16061640

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

mitogen-activated protein kinase 3

multiple interactions
increases expression
increases phosphorylation

pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]
pifithrin results in increased expression of MAPK3 protein modified form
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]

PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

pifithrin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]

PMID:16061640 PMID:16777994

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase 9

multiple interactions

pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein]
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]

PMID:16687611 PMID:16777994

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

melanocortin 1 receptor

decreases expression

pifithrin results in decreased expression of MC1R mRNA

NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483

G

transformed mouse 3T3 cell double minute 2

multiple interactions

pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA]

PMID:14766674 PMID:17487067 PMID:18940243

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

melanogenesis associated transcription factor

decreases expression

pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein

NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310

G

matrix metallopeptidase 1b (interstitial collagenase)

multiple interactions

pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein]

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

mechanistic target of rapamycin kinase

increases expression
multiple interactions

pifithrin results in increased expression of MTOR protein
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein]

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

nuclear receptor coactivator 4

multiple interactions
decreases expression

pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
pifithrin results in decreased expression of NCOA4 protein

NCBI chr14:31,881,884...31,901,210
Ensembl chr14:31,881,822...31,901,812

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions

pifithrin results in increased activity of [NFKB1 protein binds to RELA protein]

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases phosphorylation

pifithrin results in increased phosphorylation of NFKBIA protein

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nitric oxide synthase 2, inducible

multiple interactions

pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

notch 1

multiple interactions

pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein]

PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 More...

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

proliferating cell nuclear antigen

multiple interactions

pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA]

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

p53 induced death domain protein 1

multiple interactions

pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA]

NCBI chr 7:141,018,026...141,027,477
Ensembl chr 7:141,018,026...141,023,938

G

pyruvate kinase, muscle

multiple interactions

pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein]

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

polo like kinase 1

multiple interactions

[pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein

NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions
decreases expression

pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein]
pifithrin results in decreased expression of PMAIP1 protein
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]

PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897

NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636

G

polymerase (DNA directed), eta (RAD 30 related)

multiple interactions

pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein]

PMID:25125662 PMID:27694624

NCBI chr17:46,482,281...46,513,567
Ensembl chr17:46,482,281...46,513,571

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

multiple interactions

[pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

protein kinase, DNA activated, catalytic polypeptide

multiple interactions

pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein]

NCBI chr16:15,455,698...15,660,103
Ensembl chr16:15,455,730...15,660,099

G

presenilin 2

multiple interactions

pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]

NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003

G

phosphatase and tensin homolog

multiple interactions

pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

prostaglandin-endoperoxide synthase 2

multiple interactions

pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RAD51 recombinase

multiple interactions

pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein]

NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926

G

v-raf-leukemia viral oncogene 1

multiple interactions

[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

RB transcriptional corepressor 1

multiple interactions

pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein]

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions
increases expression

pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein]
pifithrin results in increased expression of RELA protein
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein]

PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

S100 calcium binding protein A9 (calgranulin B)

multiple interactions

pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein]

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

G

sestrin 1

multiple interactions

pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA]

NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420

G

sestrin 2

multiple interactions

pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein

PMID:24535669 PMID:26031332 PMID:35030298

NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812

G

solute carrier family 2 (facilitated glucose transporter), member 1

multiple interactions

pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein]
pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]

PMID:31618665 PMID:38431053

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 2 (facilitated glucose transporter), member 4

multiple interactions

pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein]

NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

multiple interactions

pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein]

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

snail family zinc finger 1

multiple interactions
increases expression

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]
pifithrin results in increased expression of SNAI1 protein

PMID:20064835 PMID:32687844

NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734

G

snail family zinc finger 2

increases expression

pifithrin results in increased expression of SNAI2 protein

NCBI chr16:14,523,716...14,527,259
Ensembl chr16:14,523,716...14,527,249

G

superoxide dismutase 2, mitochondrial

multiple interactions

pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

SRY (sex determining region Y)-box 30

multiple interactions

pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]

NCBI chr11:45,869,873...45,908,824
Ensembl chr11:45,871,137...45,908,821

G

steroidogenic acute regulatory protein

multiple interactions

pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein]

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

syncytin b

multiple interactions

pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]

NCBI chr14:69,527,827...69,549,857
Ensembl chr14:69,526,793...69,531,748

G

transforming growth factor alpha

decreases expression
multiple interactions

pifithrin results in decreased expression of TGFA protein
TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]

NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701

G

tumor necrosis factor

multiple interactions

pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

T cell receptor alpha joining 18

multiple interactions

pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of STK17A mRNA]

NCBI chr14:54,438,234...54,438,299
Ensembl chr14:54,438,234...54,438,299

G

transformation related protein 53

decreases expression
decreases activity
multiple interactions
affects expression
decreases phosphorylation

pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein
pifithrin results in decreased activity of TRP53 protein
[pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein]
pifithrin affects the expression of TRP53 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]

PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 More...

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 binding protein 1

multiple interactions

pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein]

NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888

G

tyrosinase

decreases expression

pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

ubiquitin specific peptidase 8

multiple interactions

pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]

NCBI chr 2:126,549,280...126,601,234
Ensembl chr 2:126,549,248...126,601,217

G

vimentin

multiple interactions

pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein]

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

X-linked inhibitor of apoptosis

multiple interactions

[Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

xeroderma pigmentosum, complementation group C

multiple interactions

pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA]

NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870

sodium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 5 (sodium iodide symporter), member 5

multiple interactions

sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]

NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401

tiotropium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor, muscarinic 1, CNS

affects binding

Tiotropium Bromide binds to CHRM1 protein

NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951

G

cholinergic receptor, muscarinic 2, cardiac

affects binding

Tiotropium Bromide binds to CHRM2 protein

NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349

G

cholinergic receptor, muscarinic 3, cardiac

affects binding

Tiotropium Bromide binds to CHRM3 protein

NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883

G

cholinergic receptor, muscarinic 4

affects binding

Tiotropium Bromide binds to CHRM4 protein

NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033

G

cholinergic receptor, muscarinic 5

affects binding

Tiotropium Bromide binds to CHRM5 protein

NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114

G

endothelin 1

multiple interactions

Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA]

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

paraoxonase 1

decreases activity

Tiotropium Bromide results in decreased activity of PON1 protein

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

tumor necrosis factor

decreases secretion

Tiotropium Bromide results in decreased secretion of TNF protein

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

tiquizium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

decreases activity

thiaton results in decreased activity of KCNH2 protein

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

myeloperoxidase

multiple interactions

thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239

G

nitric oxide synthase 2, inducible

multiple interactions

thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

vecuronium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family A member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP binding cassette subfamily G member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

cholinergic receptor, muscarinic 1, CNS

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr19:8,641,369...8,660,970
Ensembl chr19:8,641,153...8,660,951

G

cholinergic receptor, muscarinic 2, cardiac

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 6:36,364,928...36,505,573
Ensembl chr 6:36,365,019...36,505,349

G

cholinergic receptor, muscarinic 3, cardiac

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883

G

cholinergic receptor, muscarinic 4

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 2:91,752,531...91,760,180
Ensembl chr 2:91,757,594...91,759,033

G

cholinergic receptor, muscarinic 5

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 2:112,306,055...112,365,487
Ensembl chr 2:112,309,516...112,311,114

G

cholinergic receptor, nicotinic, alpha polypeptide 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 9:54,917,401...54,933,846
Ensembl chr 9:54,917,395...54,933,846

G

cholinergic receptor, nicotinic, alpha polypeptide 4

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339

G

cholinergic receptor, nicotinic, alpha polypeptide 7

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939

G

cholinergic receptor, nicotinic, beta polypeptide 4

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

early growth response 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

ELK1, member of ETS oncogene family

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]

NCBI chr X:20,799,634...20,816,847
Ensembl chr X:20,799,634...20,816,847

G

histone deacetylase 4

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

hexosaminidase B

increases secretion

Vecuronium Bromide results in increased secretion of HEXB protein

NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865

G

hydroxysteroid 11-beta dehydrogenase 2

increases expression
multiple interactions

Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

mitogen-activated protein kinase 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

nuclear receptor subfamily 1, group H, member 2

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]

NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

scavenger receptor class B, member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

steroidogenic acute regulatory protein

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22317
chemical entity	22316
molecular entity	22312
elemental molecular entity	18372
elemental halogen	10044
elemental bromine	156
diatomic bromine +	7
monoatomic bromine +	149

paths to the root