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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:elemental bromine
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Accession:CHEBI:36894 term browser browse the term



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3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity EXP thiazolyl blue results in decreased activity of ABCB1 protein CTD PMID:15451006 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACO2 aconitase 2 multiple interactions ISO [Calcium results in increased activity of ACO2 protein] which results in increased reduction of thiazolyl blue; [Potassium deficiency results in decreased activity of ACO2 protein] which results in decreased reduction of thiazolyl blue CTD PMID:12548706 NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273
JBrowse link
G CASP3 caspase 3 increases activity EXP thiazolyl blue results in increased activity of CASP3 protein CTD PMID:22401948 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 increases activity EXP thiazolyl blue results in increased activity of CASP8 protein CTD PMID:22401948 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases reduction
multiple interactions
EXP NQO2 protein results in increased reduction of thiazolyl blue
resveratrol inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of thiazolyl blue]
CTD PMID:29281794 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755
JBrowse link
butylscopolamine bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Butylscopolammonium Bromide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
dibromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Bromine results in decreased activity of and results in increased metabolism of ATP2A2 protein CTD PMID:32979061 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G CFTR CF transmembrane conductance regulator decreases activity EXP Bromine results in decreased activity of CFTR protein CTD PMID:15286085 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO Bromine results in increased expression of CYBB protein CTD PMID:32979061 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G NPPB natriuretic peptide B increases cleavage ISO Bromine results in increased cleavage of NPPB protein CTD PMID:32979061 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G PLN phospholamban decreases phosphorylation ISO Bromine results in decreased phosphorylation of PLN protein CTD PMID:32979061 NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716
JBrowse link
G PPEF1 protein phosphatase with EF-hand domain 1 increases expression ISO Bromine results in increased expression of PPEF1 protein CTD PMID:32979061 NCBI chr  X:18,675,067...18,827,917
Ensembl chr  X:18,675,909...18,827,921
JBrowse link
G TNNI3 troponin I3, cardiac type increases expression ISO Bromine results in increased expression of TNNI3 protein CTD PMID:32979061 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
NAN 190 hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1A 5-hydroxytryptamine receptor 1A multiple interactions ISO
EXP
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin
[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine
CTD PMID:15213358 PMID:15482641 PMID:16528294 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,957,874...63,962,507
JBrowse link
pifithrin-alpha hydrobromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ADM mRNA] CTD PMID:20064835 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G AGT angiotensinogen multiple interactions ISO pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein] CTD PMID:19808082 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AHR aryl hydrocarbon receptor affects localization
multiple interactions
EXP
ISO
pifithrin affects the localization of AHR protein
pifithrin binds to and results in increased activity of AHR protein
CTD PMID:15843497 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO pifithrin inhibits the reaction [Cisplatin affects the localization of AIFM1 protein] CTD PMID:15983031 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Copper Sulfate co-treated with pifithrin] results in increased phosphorylation of AKT1 protein; [pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of AKT1 protein; pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin results in increased expression of and results in increased phosphorylation of AKT1 protein CTD PMID:15001399 PMID:18516295 PMID:25939952 PMID:30576070 PMID:32687844 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP pifithrin results in increased expression of APAF1 protein CTD PMID:28483490 NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein] CTD PMID:24567336 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
JBrowse link
G ATF3 activating transcription factor 3 multiple interactions EXP pifithrin inhibits the reaction [sodium arsenite results in increased expression of ATF3 mRNA] CTD PMID:26148435 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions EXP pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein] CTD PMID:26259609 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions ISO pifithrin inhibits the reaction [triptolide results in increased expression of BAK1 protein] CTD PMID:30009776 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
EXP
ISO
pifithrin results in decreased expression of BAX protein
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of BAX protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Particulate Matter affects the localization of BAX protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of BAX protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased expression of BAX protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Smoke analog results in increased expression of BAX protein]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; pifithrin inhibits the reaction [Humic Substances results in increased expression of BAX protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of BAX protein]; pifithrin inhibits the reaction [triptolide results in increased expression of BAX protein]
pifithrin inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Rotenone results in increased expression of BAX protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased expression of BAX protein]
CTD PMID:11279278 PMID:12893085 PMID:14766674 PMID:16357363 PMID:16946128 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions
decreases expression
EXP
ISO
pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]
pifithrin results in decreased expression of BBC3 mRNA; pifithrin results in decreased expression of BBC3 protein
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased expression of BBC3 protein]]]
CTD PMID:18364113 PMID:18775851 PMID:19095966 PMID:19475672 PMID:20045437 More... NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of BCL2 protein; pifithrin inhibits the reaction [Pyrroles analog results in decreased expression of BCL2 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in decreased expression of BCL2 protein]
CTD PMID:17487067 PMID:18516295 PMID:18775851 PMID:26884717 PMID:30009776 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Puromycin Aminonucleoside co-treated with pifithrin] results in increased expression of BCL2L1 protein; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]]
pifithrin inhibits the reaction [triptolide results in decreased expression of BCL2L1 protein]
CTD PMID:15987750 PMID:21593185 PMID:30009776 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP pifithrin inhibits the reaction [Silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP [Topotecan co-treated with pifithrin] results in increased degradation of BIRC5 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein] CTD PMID:19812371 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BRCA1 BRCA1 DNA repair associated multiple interactions EXP pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein] CTD PMID:26259609 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions EXP pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]] CTD PMID:22886373 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123
JBrowse link
G C3 complement C3 multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of C3 protein] CTD PMID:32924446 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G C5 complement C5 multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of C5 protein] CTD PMID:32924446 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:16687611 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP2 caspase 2 multiple interactions ISO
EXP
pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Cisplatin results in increased activity of CASP2 protein]
pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP2 protein]; pifithrin promotes the reaction [Topotecan results in increased cleavage of CASP2 protein]
CTD PMID:15983031 PMID:16687611 PMID:16777994 PMID:19812371 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
decreases activity
increases cleavage
ISO
EXP
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [AGT protein modified form results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of CASP3 mRNA]; pifithrin inhibits the reaction [triptolide results in increased cleavage of CASP3 protein]
[pifithrin co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with thiocholchicine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin co-treated with Vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of CASP3 protein; pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Mustard Gas results in decreased cleavage of CASP3 protein]; pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]]; pifithrin inhibits the reaction [Pyrroles analog results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Silicon Dioxide results in increased expression of CASP3 protein modified form]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]
pifithrin results in decreased expression of CASP3 protein
pifithrin results in decreased activity of CASP3 protein
pifithrin results in increased cleavage of CASP3 protein
pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased activity of CASP3 protein]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [Topotecan results in increased activity of CASP3 protein]
CTD PMID:12556443 PMID:12665479 PMID:15144874 PMID:15976193 PMID:16687611 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP7 caspase 7 multiple interactions ISO
EXP
pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]
pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]
CTD PMID:24704558 PMID:26259609 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions EXP
ISO
pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP8 protein]
pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein]
CTD PMID:16687611 PMID:16777994 PMID:19728331 PMID:19732952 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 multiple interactions ISO
EXP
pifithrin inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Humic Substances results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of CASP9 protein modified form]
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [cobaltous chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP9 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of and results in increased activity of CASP9 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of CASP9 protein]
CTD PMID:16357363 PMID:16687611 PMID:16777994 PMID:16946128 PMID:18683188 More... NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCNB1 cyclin B1 multiple interactions
increases expression
EXP [pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein
pifithrin results in increased expression of CCNB1 mRNA; pifithrin results in increased expression of CCNB1 protein
CTD PMID:16620711 PMID:18516295 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCNG1 cyclin G1 multiple interactions ISO pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CCNG1 mRNA] CTD PMID:17487067 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,448,199
JBrowse link
G CCNG2 cyclin G2 multiple interactions EXP [pifithrin co-treated with Arsenic Trioxide] results in increased expression of CCNG2 mRNA CTD PMID:35030298 NCBI chr 4:77,157,207...77,170,060
Ensembl chr 4:77,157,207...77,433,388
JBrowse link
G CDC25A cell division cycle 25A multiple interactions EXP pifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA] CTD PMID:26148435 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein CTD PMID:18516295 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G CDH1 cadherin 1 multiple interactions
decreases expression
EXP pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]
pifithrin results in decreased expression of CDH1 protein
CTD PMID:32687844 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression
multiple interactions
increases phosphorylation
EXP pifithrin results in increased expression of CDK1 protein
[pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein
pifithrin results in increased phosphorylation of CDK1 protein
CTD PMID:16620711 PMID:18516295 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions EXP pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK2 protein] CTD PMID:26451628 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
decreases expression
increases expression
ISO
EXP
pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [arecoline hydrobromide results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]
pifithrin results in decreased expression of CDKN1A mRNA
pifithrin results in decreased expression of CDKN1A protein
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; pifithrin inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased expression of CDKN1A protein]]; pifithrin inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Quercetin results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of CDKN1A mRNA]; pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
pifithrin results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [Vanadates results in increased activity of CDKN1A protein]; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
CTD PMID:11889192 PMID:11931974 PMID:12413886 PMID:12893085 PMID:15144874 More... NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
JBrowse link
G CGB3 chorionic gonadotropin subunit beta 3 multiple interactions EXP pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CGB3 mRNA] CTD PMID:24361490 NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions EXP pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein] CTD PMID:26259609 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 multiple interactions EXP pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of BAX protein]]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]] CTD PMID:21660965 NCBI chr 6:139,371,807...139,374,648
Ensembl chr 6:139,371,807...139,374,648
JBrowse link
G CREBBP CREB binding protein multiple interactions ISO pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein] CTD PMID:13679428 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCR4 mRNA] CTD PMID:20064835 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,119,177
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] CTD PMID:16687611 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
decreases activity
ISO
EXP
pifithrin results in increased expression of CYP1A1 mRNA; pifithrin results in increased expression of CYP1A1 protein
pifithrin results in decreased activity of CYP1A1 protein
CTD PMID:15698582 PMID:15843497 PMID:16258175 PMID:22044530 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
increases expression
EXP pifithrin results in decreased activity of CYP1A2 protein
pifithrin results in increased expression of CYP1A2 mRNA; pifithrin results in increased expression of CYP1A2 protein
CTD PMID:16258175 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
decreases activity
multiple interactions
EXP
ISO
pifithrin results in increased expression of CYP1B1 mRNA
pifithrin results in decreased activity of CYP1B1 protein
pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]
CTD PMID:16258175 PMID:35908932 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DDB2 damage specific DNA binding protein 2 multiple interactions EXP pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of DDB2 mRNA]; pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DDB2 mRNA] CTD PMID:20064835 PMID:27694624 NCBI chr11:47,214,454...47,239,217
Ensembl chr11:47,214,465...47,239,217
JBrowse link
G DUSP1 dual specificity phosphatase 1 multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of DUSP1 mRNA] CTD PMID:20064835 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP pifithrin results in decreased expression of EDN1 mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]
CTD PMID:19098008 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EDNRB endothelin receptor type B decreases expression EXP pifithrin results in decreased expression of EDNRB mRNA CTD PMID:19098008 NCBI chr13:77,895,487...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G ERVFRD-1 endogenous retrovirus group FRD member 1, envelope multiple interactions EXP pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA] CTD PMID:24361490 NCBI chr 6:11,102,489...11,111,725
Ensembl chr 6:11,102,324...11,111,845
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP
ISO
pifithrin inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of FAS protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of FAS protein] CTD PMID:11779855 PMID:16687611 PMID:26451628 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FDXR ferredoxin reductase multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA] CTD PMID:20064835 NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA] CTD PMID:20064835 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions EXP pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased degradation of FTH1 protein] CTD PMID:32687844 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions ISO
EXP
pifithrin inhibits the reaction [Excitatory Amino Acid Agents results in increased expression of GADD45A mRNA]
pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GADD45A mRNA]
CTD PMID:20064835 PMID:20955365 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GDF15 mRNA] CTD PMID:20064835 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GLB1 galactosidase beta 1 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of GLB1 protein] CTD PMID:33737050 NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of GPX4 protein] CTD PMID:33737050 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP
ISO
[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein]
pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [quinone analog results in increased expression of H2AX protein modified form]
CTD PMID:19732952 PMID:19735649 PMID:25448276 PMID:26259609 PMID:33961949 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
increases phosphorylation
ISO pifithrin inhibits the reaction [triptolide results in decreased phosphorylation of IKBKB protein]
pifithrin results in increased phosphorylation of IKBKB protein
CTD PMID:31618665 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO pifithrin results in increased expression of JUN protein CTD PMID:16061640 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase decreases expression EXP pifithrin results in decreased expression of KIT mRNA CTD PMID:19098008 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783
JBrowse link
G KITLG KIT ligand decreases expression
multiple interactions
EXP pifithrin results in decreased expression of KITLG mRNA
pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]
CTD PMID:19098008 NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851
JBrowse link
G LASP1 LIM and SH3 protein 1 increases expression EXP pifithrin results in increased expression of LASP1 mRNA CTD PMID:28232485 NCBI chr17:38,870,058...38,921,770
Ensembl chr17:38,869,859...38,921,770
JBrowse link
G LASP1NB LASP1 neighbor decreases expression EXP pifithrin results in decreased expression of LASP1NB mRNA CTD PMID:28232485 NCBI chr17:38,925,614...38,929,381
Ensembl chr17:38,925,614...38,929,381
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of LDHA protein] CTD PMID:38431053 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G LYZ lysozyme multiple interactions ISO pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of LYZ2 mRNA] CTD PMID:18550754 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
increases expression
ISO
EXP
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
pifithrin results in increased phosphorylation of MAPK1 protein
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK1 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]
pifithrin results in increased expression of MAPK1 protein modified form
CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK10 mitogen-activated protein kinase 10 multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK10 protein] CTD PMID:16687611 NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 increases phosphorylation
multiple interactions
ISO pifithrin results in increased phosphorylation of MAPK14 protein
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK14 protein]
CTD PMID:16005925 PMID:16061640 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases expression
increases phosphorylation
EXP
ISO
pifithrin inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]
pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of MAPK3 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased phosphorylation of MAPK3 protein]; pifithrin promotes the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]
pifithrin results in increased expression of MAPK3 protein modified form
CTD PMID:12884365 PMID:16005925 PMID:16687611 PMID:28483490 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO
EXP
pifithrin results in increased phosphorylation of MAPK8 protein
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK8 protein]
CTD PMID:16061640 PMID:16777994 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO
EXP
pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of MAPK9 protein]
pifithrin inhibits the reaction [Silybin results in increased phosphorylation of MAPK9 protein]
CTD PMID:16687611 PMID:16777994 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MC1R melanocortin 1 receptor decreases expression EXP pifithrin results in decreased expression of MC1R mRNA CTD PMID:19098008 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions ISO pifithrin inhibits the reaction [Doxorubicin results in increased expression of MDM2 mRNA]; pifithrin inhibits the reaction [Vehicle Emissions results in decreased expression of MDM2 protein]
pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of MDM2 mRNA]
CTD PMID:14766674 PMID:17487067 PMID:18940243 NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MITF melanocyte inducing transcription factor decreases expression EXP pifithrin results in decreased expression of MITF mRNA; pifithrin results in decreased expression of MITF protein CTD PMID:19098008 NCBI chr 3:69,739,464...69,968,332
Ensembl chr 3:69,739,456...69,968,336
JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions EXP pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein] CTD PMID:18557930 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MTOR mechanistic target of rapamycin kinase increases expression
multiple interactions
EXP pifithrin results in increased expression of MTOR protein
pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of MTOR protein]
CTD PMID:32687844 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
JBrowse link
G NCOA4 nuclear receptor coactivator 4 multiple interactions
decreases expression
EXP pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]
pifithrin results in decreased expression of NCOA4 protein
CTD PMID:32687844 NCBI chr10:46,005,088...46,030,623
Ensembl chr10:46,005,088...46,030,623
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO pifithrin results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:16061640 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation ISO pifithrin results in increased phosphorylation of NFKBIA protein CTD PMID:31618665 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] CTD PMID:26086121 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOTCH1 notch receptor 1 multiple interactions EXP pifithrin inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein] CTD PMID:25118938 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO
EXP
pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[pifithrin co-treated with Arsenic Trioxide] results in decreased expression of PARP1 protein; [pifithrin co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [pifithrin results in increased susceptibility to Plant Preparations] which results in increased cleavage of PARP1 protein; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; pifithrin promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; pifithrin promotes the reaction [Mustard Gas results in increased cleavage of PARP1 protein]
CTD PMID:16687611 PMID:16777994 PMID:19732952 PMID:20045437 PMID:21810437 More... NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO pifithrin inhibits the reaction [Arsenic Trioxide results in increased expression of PCNA mRNA] CTD PMID:17487067 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PIDD1 p53-induced death domain protein 1 multiple interactions ISO pifithrin inhibits the reaction [Cisplatin results in increased expression of PIDD1 mRNA] CTD PMID:15983031 NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753
JBrowse link
G PKM pyruvate kinase M1/2 multiple interactions EXP pifithrin inhibits the reaction [icaritin results in decreased expression of PKM mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of PKM protein] CTD PMID:38431053 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819
JBrowse link
G PLK1 polo like kinase 1 multiple interactions EXP [pifithrin co-treated with Paclitaxel] results in increased expression of PLK1 protein CTD PMID:18516295 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
decreases expression
EXP
ISO
pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of PMAIP1 mRNA]
pifithrin results in decreased expression of PMAIP1 protein
pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PMAIP1 protein]
CTD PMID:20045437 PMID:21810437 PMID:33031904 PMID:35022897 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
JBrowse link
G POLH DNA polymerase eta multiple interactions EXP pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]; pifithrin inhibits the reaction [Lomustine results in increased expression of POLH protein] CTD PMID:25125662 PMID:27694624 NCBI chr 6:43,576,185...43,620,523
Ensembl chr 6:43,576,185...43,620,523
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [pifithrin co-treated with Quercetin] results in increased phosphorylation of PRKAA1 protein CTD PMID:24535669 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit multiple interactions EXP pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein] CTD PMID:22226932 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PSEN2 presenilin 2 multiple interactions EXP pifithrin inhibits the reaction [PSEN2 protein mutant form promotes the reaction [Staurosporine results in increased activity of CASP3 protein]] CTD PMID:12556443 NCBI chr 1:226,870,616...226,903,668
Ensembl chr 1:226,870,184...226,927,726
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO pifithrin inhibits the reaction [Diquat results in increased expression of PTGS2 protein] CTD PMID:29484840 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RAD51 RAD51 recombinase multiple interactions EXP pifithrin inhibits the reaction [tetrachlorobenzoquinone results in decreased expression of RAD51 protein] CTD PMID:27989139 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions EXP [pifithrin co-treated with Paclitaxel] results in increased phosphorylation of RAF1 protein CTD PMID:18516295 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions ISO pifithrin inhibits the reaction [Humic Substances results in decreased expression of RB1 protein] CTD PMID:18683188 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; pifithrin inhibits the reaction [triptolide results in decreased expression of RELA protein]; pifithrin promotes the reaction [RELA protein binds to CREBBP protein]
pifithrin results in increased activity of [NFKB1 protein binds to RELA protein]
pifithrin results in increased expression of RELA protein
CTD PMID:12665479 PMID:13679428 PMID:16061640 PMID:31618665 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G S100A9 S100 calcium binding protein A9 multiple interactions ISO pifithrin inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein] CTD PMID:32924446 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SESN1 sestrin 1 multiple interactions EXP pifithrin inhibits the reaction [sodium arsenite results in increased expression of SESN1 mRNA] CTD PMID:26148435 NCBI chr 6:108,984,309...109,094,846
Ensembl chr 6:108,984,309...109,094,846
JBrowse link
G SESN2 sestrin 2 multiple interactions ISO
EXP
pifithrin inhibits the reaction [Rotenone results in increased expression of SESN2 protein]
[pifithrin co-treated with Arsenic Trioxide] results in increased expression of SESN2 mRNA; [pifithrin co-treated with Quercetin] results in increased expression of SESN2 protein
CTD PMID:24535669 PMID:26031332 PMID:35030298 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions ISO
EXP
pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A1 protein]
pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 mRNA]; pifithrin inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]
CTD PMID:31618665 PMID:38431053 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO pifithrin inhibits the reaction [triptolide results in decreased expression of SLC2A4 protein] CTD PMID:31618665 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions ISO pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC7A11 protein] CTD PMID:33737050 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SNAI1 snail family transcriptional repressor 1 multiple interactions
increases expression
EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]
pifithrin results in increased expression of SNAI1 protein
CTD PMID:20064835 PMID:32687844 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886
JBrowse link
G SNAI2 snail family transcriptional repressor 2 increases expression EXP pifithrin results in increased expression of SNAI2 protein CTD PMID:32687844 NCBI chr 8:48,917,598...48,921,429
Ensembl chr 8:48,917,598...48,921,740
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO pifithrin inhibits the reaction [Rosiglitazone results in increased expression of SOD2 protein] CTD PMID:19226370 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX30 SRY-box transcription factor 30 multiple interactions EXP pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein] CTD PMID:25435374 NCBI chr 5:157,625,679...157,671,480
Ensembl chr 5:157,625,679...157,671,480
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of STAR protein] CTD PMID:32199951 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STK17A serine/threonine kinase 17a multiple interactions EXP pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of STK17A mRNA] CTD PMID:20064835 NCBI chr 7:43,583,108...43,627,379
Ensembl chr 7:43,582,758...43,650,713
JBrowse link
G TGFA transforming growth factor alpha decreases expression
multiple interactions
ISO pifithrin results in decreased expression of TGFA protein
TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]
CTD PMID:12143041 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO pifithrin inhibits the reaction [Diquat results in increased expression of TNF protein] CTD PMID:29484840 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 affects expression
decreases activity
multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
pifithrin affects the expression of TRP53 protein
pifithrin results in decreased activity of TRP53 protein
[pifithrin co-treated with cobaltous chloride] results in increased expression of and affects the localization of TP53 protein; [pifithrin results in decreased activity of TP53 protein] results in decreased susceptibility to [Oxaliplatin results in increased activity of CASP3 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to Oxaliplatin; [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form]; pifithrin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Air Pollutants results in increased abundance of Benzo(a)pyrene] which results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [[KITLG protein co-treated with EDN1 protein] results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite affects the localization of TP53 protein]; pifithrin inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [CITED2 mutant form promotes the reaction [Cisplatin results in increased expression of TP53 protein]]; pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Ellagic Acid promotes the reaction [Quercetin results in increased phosphorylation of TP53 protein]]; pifithrin inhibits the reaction [Etoposide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]; pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein]; pifithrin inhibits the reaction [KITLG protein results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [olaquindox results in decreased expression of TP53 protein]; pifithrin inhibits the reaction [Particulate Matter affects the localization of TRP53 protein]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Particulate Matter results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [Pyrroles analog results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Quercetin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of TP53 protein]; pifithrin inhibits the reaction [Smoke analog results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [SOX30 protein results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Resveratrol]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein modified form]; pifithrin results in decreased susceptibility to [Oxaliplatin results in increased expression of TP53 protein]
pifithrin results in decreased expression of TP53 mRNA; pifithrin results in decreased expression of TP53 protein
pifithrin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TP53 protein]; pifithrin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; pifithrin inhibits the reaction [APP protein alternative form results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Arsenic Trioxide results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased activity of TP53 protein]; pifithrin inhibits the reaction [cyanoginosin LR results in increased expression of TP53 protein]; pifithrin inhibits the reaction [dibenzo(a,l)pyrene results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Diquat results in increased expression of and affects the localization of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased localization of TP53 protein modified form]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased localization of TP53 protein]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 mRNA]; pifithrin inhibits the reaction [Ropivacaine results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 protein results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [TP53 protein results in increased susceptibility to Cisplatin]; pifithrin inhibits the reaction [triptolide results in increased expression of and results in increased phosphorylation of TP53 protein]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein modified form]; pifithrin inhibits the reaction [triptolide results in increased expression of TP53 protein]; pifithrin results in decreased expression of and results in decreased phosphorylation of TP53 protein; TP53 protein affects the reaction [pifithrin results in decreased expression of TGFA protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [pifithrin results in increased expression of and results in increased activity of TRP53 protein]; [pifithrin results in decreased activity of TP53 protein] which results in decreased susceptibility to deoxynivalenol; [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; [pifithrin results in decreased activity of TRP53 protein] which results in decreased susceptibility to zearalenol; pifithrin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]]; pifithrin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]; pifithrin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TRP53 protein]; pifithrin inhibits the reaction [deoxynivalenol results in increased phosphorylation of and results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of and results in increased phosphorylation of TRP53 protein]; pifithrin inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; pifithrin inhibits the reaction [Vanadates results in increased activity of TRP53 protein]; pifithrin inhibits the reaction [Vehicle Emissions results in increased phosphorylation of TRP53 protein]; pifithrin results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein; TRP53 protein affects the reaction [pifithrin results in decreased expression of CDKN1A mRNA]
CTD PMID:10702639 PMID:11279278 PMID:11889192 PMID:11914272 PMID:11931974 More... NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 multiple interactions EXP pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:26259609 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
G TYR tyrosinase decreases expression EXP pifithrin results in decreased expression of TYR mRNA; pifithrin results in decreased expression of TYR protein CTD PMID:19098008 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G USP8 ubiquitin specific peptidase 8 multiple interactions EXP pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BAX protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased expression of PMAIP1 protein] CTD PMID:35022897 NCBI chr15:50,424,405...50,514,421
Ensembl chr15:50,424,380...50,514,421
JBrowse link
G VIM vimentin multiple interactions EXP pifithrin inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein] CTD PMID:32687844 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP [Topotecan co-treated with pifithrin] results in increased degradation of XIAP protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein] CTD PMID:19812371 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor multiple interactions EXP pifithrin inhibits the reaction [benzo(a)pyrene diolepoxide I results in increased expression of XPC mRNA] CTD PMID:27694624 NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,145...14,178,621
JBrowse link
sodium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium bromide inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m] CTD PMID:12488351 NCBI chr19:17,871,945...17,895,174
Ensembl chr19:17,871,945...17,895,174
JBrowse link
tiotropium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM1 cholinergic receptor muscarinic 1 affects binding EXP Tiotropium Bromide binds to CHRM1 protein CTD PMID:21870878 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 affects binding EXP Tiotropium Bromide binds to CHRM2 protein CTD PMID:21870878 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 affects binding EXP Tiotropium Bromide binds to CHRM3 protein CTD PMID:21870878 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 affects binding EXP Tiotropium Bromide binds to CHRM4 protein CTD PMID:21870878 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 affects binding EXP Tiotropium Bromide binds to CHRM5 protein CTD PMID:21870878 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G EDN1 endothelin 1 multiple interactions EXP Tiotropium Bromide inhibits the reaction [Oxotremorine results in increased expression of EDN1 mRNA] CTD PMID:22796455 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G PON1 paraoxonase 1 decreases activity EXP Tiotropium Bromide results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G TNF tumor necrosis factor decreases secretion EXP Tiotropium Bromide results in decreased secretion of TNF protein CTD PMID:21352583 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G MPO myeloperoxidase multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
vecuronium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein] CTD PMID:30036686 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein] CTD PMID:30036686 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,304,389
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:9846649 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein] CTD PMID:9846649 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRM4 cholinergic receptor muscarinic 4 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9846649 NCBI chr11:46,383,789...46,391,776
Ensembl chr11:46,383,789...46,391,776
JBrowse link
G CHRM5 cholinergic receptor muscarinic 5 multiple interactions EXP Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr15:33,968,497...34,067,458
Ensembl chr15:33,968,497...34,067,458
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein] CTD PMID:16931985 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:16931985 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CHRNB4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]] CTD PMID:16931985 NCBI chr15:78,624,111...78,661,641
Ensembl chr15:78,624,111...78,727,754
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein] CTD PMID:31846720 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein] CTD PMID:30959089 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein] CTD PMID:29486207 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,520...47,650,604
JBrowse link
G HDAC4 histone deacetylase 4 multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein] CTD PMID:31846720 NCBI chr 2:239,048,168...239,401,649
NCBI chr 2:239,193,331...239,195,457
Ensembl chr 2:239,048,168...239,401,654
JBrowse link
G HEXB hexosaminidase subunit beta increases secretion EXP Vecuronium Bromide results in increased secretion of HEXB protein CTD PMID:19758318 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 increases expression
multiple interactions
EXP Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:29486207 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] CTD PMID:29486207 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] CTD PMID:29486207 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein] CTD PMID:30036686 NCBI chr19:50,376,457...50,383,388
Ensembl chr19:50,329,653...50,383,388
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein] CTD PMID:30036686 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions EXP Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein] CTD PMID:30036686 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein] CTD PMID:31846720 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26505
    chemical entity 26485
      molecular entity 26467
        elemental molecular entity 19812
          elemental halogen 9962
            elemental bromine 157
              diatomic bromine + 7
              monoatomic bromine + 150
paths to the root