inorganic radical anion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	inorganic radical anion	go back to main search page
Accession:	CHEBI:36876	browse the term
Synonyms:	related_synonym:	inorganic radical anions

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Rat (97) Mouse (97) Human (98) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (97)

superoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

aconitase 1

decreases activity
multiple interactions

Superoxides results in decreased activity of ACO1 protein
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

multiple interactions
decreases activity

[[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261

G

adenosine deaminase

multiple interactions

ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088

G

angiotensinogen

multiple interactions
increases abundance

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]
SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]

PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 More...

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions

[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946

G

aldo-keto reductase family 1, member C3

multiple interactions

[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides

PMID:19442656 PMID:21910479

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7, member A2

multiple interactions

[[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:151,552,343...151,560,909

G

albumin

increases chemical synthesis
multiple interactions

ALB protein modified form results in increased chemical synthesis of Superoxides
Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions

[ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides

NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,130,883...40,158,677

G

apolipoprotein E

increases chemical synthesis
increases abundance
multiple interactions

APOE gene mutant form results in increased chemical synthesis of Superoxides
APOE gene mutant form results in increased abundance of Superoxides
imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides]

PMID:11397713 PMID:12871831

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions
increases chemical synthesis

3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; Resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides]

PMID:16212921 PMID:22886847

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

multiple interactions

Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925

G

ARF GTPase 6

multiple interactions

1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]

NCBI chr 6:93,589,777...93,590,925
Ensembl chr 6:87,840,142...87,874,114

G

arrestin, beta 2

affects abundance

ARRB2 protein affects the abundance of Superoxides

NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850

G

antioxidant 1 copper chaperone

multiple interactions

ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]

NCBI chr10:40,065,525...40,080,627
Ensembl chr10:39,564,857...39,579,950

G

ATPase copper transporting alpha

increases abundance
multiple interactions

ATP7A mutant form results in increased abundance of Superoxides
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]

PMID:18768397 PMID:23884884

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354

G

complement C5

multiple interactions
increases abundance

8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994

G

catalase

multiple interactions

CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cystathionine beta synthase

affects abundance
multiple interactions

CBS protein affects the abundance of Superoxides
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,708,090...9,732,764

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein]
Superoxides results in increased expression of CCL2 mRNA
1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA]

PMID:8856246 PMID:19158351

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

CD38 molecule

affects localization
multiple interactions

Superoxides affects the localization of CD38 protein
tempol inhibits the reaction [Superoxides affects the localization of CD38 protein]

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986

G

C-reactive protein

multiple interactions

CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

cytochrome b-245 alpha chain

multiple interactions
increases abundance

CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides]
CYBA protein results in increased abundance of Superoxides

PMID:10720412 PMID:14871555 PMID:20523355

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions

CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides]
IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]

PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases abundance

CYP1A1 protein results in increased abundance of Superoxides

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

dicarbonyl and L-xylulose reductase

multiple interactions
increases chemical synthesis

[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides]
DCXR protein results in increased chemical synthesis of Superoxides

NCBI chr10:106,504,730...106,506,619

G

DNA-damage inducible transcript 3

increases abundance
increases expression
multiple interactions

DDIT3 protein results in increased abundance of Superoxides
Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

endothelin 1

multiple interactions
increases abundance

[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]
NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]

PMID:20977430 PMID:23940720

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

affects abundance

EDNRA protein affects the abundance of Superoxides

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049

G

E1A binding protein p300

decreases abundance

EP300 protein results in decreased abundance of Superoxides

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythropoietin

multiple interactions

EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946

G

ERCC excision repair 6, chromatin remodeling factor

multiple interactions
decreases abundance
increases abundance

3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]
ERCC6 protein results in decreased abundance of Superoxides

NCBI chr16:7,771,311...7,841,895
Ensembl chr16:7,765,013...7,835,587

G

estrogen receptor 1

multiple interactions

[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides]

PMID:18354059 PMID:23000059

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

fragile X messenger ribonucleoprotein 1

multiple interactions
increases abundance

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides]

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:147,240,301...147,278,050

G

fibronectin 1

multiple interactions

Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest specific 5

increases expression

Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein

NCBI chr13:75,836,963...75,840,284

G

GTP cyclohydrolase 1

affects abundance

GCH1 protein affects the abundance of Superoxides

NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698

G

heme oxygenase 1

multiple interactions
decreases abundance
increases abundance

[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]
HMOX1 protein results in decreased abundance of Superoxides
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]

PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

HRas proto-oncogene, GTPase

increases abundance
multiple interactions

HRAS protein mutant form results in increased abundance of Superoxides
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family B (small) member 1

multiple interactions
decreases abundance

[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein
HSPB1 protein results in decreased abundance of Superoxides

PMID:14975446 PMID:19193722

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

immediate early response 3

affects chemical synthesis

IER3 protein affects the chemical synthesis of Superoxides

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583

G

insulin-like growth factor 1

decreases abundance

IGF1 protein results in decreased abundance of Superoxides

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 1 beta

multiple interactions
increases abundance

diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides]

PMID:16354686 PMID:21211511

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 5

multiple interactions

1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213

G

insulin 1

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

G

integrin subunit alpha 3

multiple interactions

[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein

NCBI chr10:80,486,998...80,522,548
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit beta 1

multiple interactions

[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein]
Superoxides results in increased expression of JUN mRNA
SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]

PMID:9067545 PMID:16572112

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

lysine acetyltransferase 2A

decreases abundance

KAT2A protein results in decreased abundance of Superoxides

NCBI chr10:86,132,535...86,140,877
Ensembl chr10:85,632,216...85,640,166

G

lysine acetyltransferase 2B

decreases abundance

KAT2B protein results in decreased abundance of Superoxides

NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,562,288...6,667,064

G

kinase insert domain receptor

increases phosphorylation

Superoxides results in increased phosphorylation of KDR protein

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

leptin

multiple interactions
increases abundance

acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides]
[LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides

PMID:11342529 PMID:16380530

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions
increases abundance

acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Superoxides results in increased phosphorylation of MAPK1 protein

PMID:16572112 PMID:19268487

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Superoxides results in increased phosphorylation of MAPK3 protein

PMID:16572112 PMID:19268487

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

Superoxides results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation

Superoxides results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

myeloperoxidase

multiple interactions

[MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 3

decreases response to substance

MT3 protein results in decreased susceptibility to Superoxides

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158

G

neutrophil cytosolic factor 1

multiple interactions

NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

multiple interactions

NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides]

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277

G

nitric oxide synthase 2

multiple interactions

[Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
affects chemical synthesis
decreases abundance
increases abundance

7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein]
NOS3 protein affects the chemical synthesis of Superoxides
NOS3 protein results in decreased abundance of Superoxides
[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]
[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]

PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 More...

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

NADPH oxidase 1

multiple interactions
increases abundance

[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides]
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]

PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 3

multiple interactions

[resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides

NCBI chr 1:46,643,277...46,708,109
Ensembl chr 1:44,236,992...44,302,851

G

NADPH oxidase 4

multiple interactions

NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

Parkinsonism associated deglycase

multiple interactions

PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides]

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970

G

pyruvate dehydrogenase E1 subunit alpha 1

affects abundance

PDHA1 protein affects the abundance of Superoxides

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:34,700,409...34,714,311

G

PTEN induced kinase 1

affects abundance

PINK1 protein affects the abundance of Superoxides

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635

G

DNA polymerase gamma, catalytic subunit

increases chemical synthesis
multiple interactions

POLG gene mutant form results in increased chemical synthesis of Superoxides
Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]

NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:133,382,766...133,398,567

G

proopiomelanocortin

increases abundance

POMC protein results in increased abundance of Superoxides

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

paraoxonase 2

increases expression

Superoxides results in increased expression of PON2 protein

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:33,389,714...33,425,248

G

cytochrome p450 oxidoreductase

multiple interactions

[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245

G

protein kinase C, alpha

multiple interactions

[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

multiple interactions

[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

ribosomal protein S6 kinase B1

multiple interactions

[resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

selenoprotein H

decreases abundance

SELENOH protein results in decreased abundance of Superoxides

NCBI chr 3:90,158,541...90,160,108
Ensembl chr 3:69,752,757...69,753,417

G

serpin family E member 1

multiple interactions

[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

sirtuin 1

multiple interactions

SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 25 member 14

multiple interactions

SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides]

NCBI chr X:132,685,518...132,723,705
Ensembl chr X:127,807,449...127,845,823

G

sphingomyelin phosphodiesterase 1

multiple interactions

SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides]

NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:159,892,859...159,896,794

G

superoxide dismutase 1

increases abundance
decreases abundance
multiple interactions
decreases chemical synthesis

SOD1 protein results in increased abundance of Superoxides
SOD1 protein results in decreased abundance of Superoxides
[[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]
SOD1 protein results in decreased chemical synthesis of Superoxides
[SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]

PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 More...

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases metabolic processing
affects metabolic processing
decreases abundance
multiple interactions
increases expression
affects abundance
affects chemical synthesis

SOD2 protein results in increased metabolism of Superoxides
SOD2 protein polymorphism affects the metabolism of Superoxides
SOD2 protein results in decreased abundance of Superoxides
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [Troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [sodium arsenite results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA]
Superoxides results in increased expression of SOD2 protein
[Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]
[SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides]
SOD2 protein affects the chemical synthesis of Superoxides

PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 More...

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions

[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]

PMID:16864745 PMID:23884884

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990

G

transforming growth factor, beta 1

multiple interactions
increases secretion
increases abundance

Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA]
Superoxides results in increased secretion of TGFB1 protein
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein]
TGFB1 protein results in increased abundance of Superoxides

PMID:12606818 PMID:16572112 PMID:19268487

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions
affects abundance
decreases abundance
increases abundance

[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
TNF protein affects the abundance of Superoxides
TNF gene mutant form results in decreased abundance of Superoxides
TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides]

PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

multiple interactions

[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

uncoupling protein 1

multiple interactions

UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852

G

uncoupling protein 2

multiple interactions
decreases abundance

[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA
UCP2 protein results in decreased abundance of Superoxides

PMID:10860543 PMID:25440059

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

vav guanine nucleotide exchange factor 2

multiple interactions
increases abundance

2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]

NCBI chr 3:30,982,754...31,152,116
Ensembl chr 3:10,584,688...10,754,052

G

vitamin D receptor

decreases abundance

VDR protein results in decreased abundance of Superoxides

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677

G

xanthine dehydrogenase

multiple interactions
increases chemical synthesis

[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]

PMID:19268487 PMID:19555678

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19904
chemical entity	19902
molecular entity	19901
ion	17105
anion	16667
radical anion	97
inorganic radical anion	97
(dioxido)hydroxidodioxidophosphate(.1-)	0
(dioxido)trioxidophosphate(.2-)	0
bis(oxidonitrate)(N--N)(.1-)	0
dibromide(.1-)	0
dichloride(.1-)	0
difluoride(.1-)	0
dihydridotellurate(.1-)	0
dioxidonitrate(.2-)	0
dioxidosulfate(.1-)	0
diphosphide(.1-)	0
disulfide(.1-)	0
hexanitride(.1-)	0
hydridonitrate(.1-)	0
hydroxidodioxidophosphate(.1-)	0
hydroxidooxidophosphate(.1-)	0
hydroxidotrioxidophosphate(.1-)	0
oxide(.1-)	0
oxidodinitrate(.1-)	0
oxidoiodate(.2-)	0
oxidonitrate(2.1-) (triplet)	0
oxidosulfate(.1-)	0
ozonide	0
selenide(.1-)	0
sulfide(.1-)	0
superoxide	97
telluride(.1-)	0
tetraoxidophosphate(.2-)	0
tetraoxidosulfate(.1-)	0
trihydridoaluminate(.1-)	0
trihydridoantimonate(.1-)	0
trihydridoarsenate(.1-)	0
trihydridobismuthate(.1-)	0
trihydridoborate(.1-)	0
trihydridonitrate(.1-)	0
trihydridophosphate(.1-)	0
trioxidonitrate(.2-)	0
trioxidophosphate(.2-)	0
trioxidosilicate(.1-)	0
trioxidosulfate(.1-)	0
trioxidosulfidosulfate(.1-)	0
trioxidotellurate(.1-)	0
trisulfide(.1-)	0

paths to the root