14-hydroxy steroid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	14-hydroxy steroid	go back to main search page
Accession:	CHEBI:36860	browse the term
Synonyms:	related_synonym:	14-hydroxy steroids

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Rat (274 ) Mouse (274 ) Human (276 ) Chinchilla (0 ) Bonobo (0 ) Dog (1 ) Squirrel (0 ) Pig (2 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (274)

20-hydroxyecdysone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Ecdysterone results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

affects expression

ISO

Ecdysterone affects the expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases activity
increases cleavage

ISO

Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein

PMID:29126784 PMID:33878320

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

heme oxygenase 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

decreases expression
increases expression

ISO

Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

insulin-like growth factor 1

multiple interactions

ISO

[Diosgenin co-treated with Ecdysterone] results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

mechanistic target of rapamycin kinase

affects expression

ISO

Ecdysterone affects the expression of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases response to substance

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Ecdysterone results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ISO

[Diosgenin co-treated with Ecdysterone] results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

sequestosome 1

affects expression

ISO

Ecdysterone affects the expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

bufalin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

actin, beta

increases expression

ISO

bufalin results in increased expression of ACTB protein

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:16,776,661...16,780,242

G

actin, gamma 1

increases expression

ISO

bufalin results in increased expression of ACTG1 protein

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:106,118,108...106,120,951

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

bufalin results in increased phosphorylation of and results in decreased expression of AKT1 protein
bufalin results in decreased phosphorylation of AKT1 protein

PMID:23949904 PMID:36924737

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

apoptotic peptidase activating factor 1

increases expression

ISO

bufalin results in increased expression of APAF1 protein

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

BCL2, apoptosis regulator

decreases expression

ISO

bufalin results in decreased expression of BCL2 mRNA; bufalin results in decreased expression of BCL2 protein

PMID:7658701 PMID:27444971

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

bufalin results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 10

decreases expression

ISO

bufalin results in decreased expression of BCL2L10 protein

NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:84,987,833...84,993,872

G

Bcl2-like 11

increases expression

ISO

bufalin results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

caspase 3

increases expression
increases activity

ISO

bufalin results in increased expression of CASP3 mRNA; bufalin results in increased expression of CASP3 protein modified form
bufalin results in increased activity of CASP3 protein

PMID:27444971 PMID:36924737

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases activity

ISO

bufalin results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

COPI coat complex subunit epsilon

decreases expression

ISO

bufalin results in decreased expression of COPE protein

NCBI chr16:19,148,832...19,159,052
Ensembl chr16:19,148,832...19,159,212

G

cytochrome c, somatic

multiple interactions
increases expression

ISO

bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]
bufalin results in increased expression of CYCS protein

PMID:23091618 PMID:27444971

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
multiple interactions
increases expression

ISO

CYP3A4 protein results in increased metabolism of bufalin
bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; bufalin results in increased expression of and results in increased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]
bufalin results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

increases expression

ISO

bufalin results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

ISO

bufalin results in increased expression of DNAJB11 protein

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

deoxyuridine triphosphatase

decreases expression

ISO

bufalin results in decreased expression of DUT protein

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

eukaryotic translation initiation factor 2 alpha kinase 3

decreases phosphorylation

ISO

bufalin results in decreased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

endonuclease G

increases expression

ISO

bufalin results in increased expression of ENDOG mRNA; bufalin results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

enolase 1

decreases expression

ISO

bufalin results in decreased expression of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

Fas cell surface death receptor

increases expression

ISO

bufalin results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

bufalin results in increased expression of FASLG protein

PMID:27444971 PMID:36924737

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of FOS mRNA]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

forkhead box O1

multiple interactions

ISO

bufalin results in increased expression of and results in decreased phosphorylation of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

growth factor receptor bound protein 2

decreases expression

ISO

bufalin results in decreased expression of GRB2 protein

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutathione S-transferase pi 1

decreases expression

ISO

bufalin results in decreased expression of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

ISO

bufalin results in decreased expression of HNRNPH1 protein

NCBI chr10:35,187,412...35,203,909
Ensembl chr10:35,193,890...35,203,906

G

heterogeneous nuclear ribonucleoprotein K

decreases expression

ISO

bufalin results in decreased expression of HNRNPK protein

NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565

G

heat shock protein family A (Hsp70) member 5

decreases expression

ISO

bufalin results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

multiple interactions
decreases response to substance
decreases expression

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [bufalin results in decreased expression of HSPB1 protein]; bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]; HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]; HSPB1 protein inhibits the reaction [bufalin inhibits the reaction [HSPB1 protein binds to CYCS protein]]; HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]
HSPB1 protein results in decreased susceptibility to bufalin

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

interleukin 1 beta

multiple interactions
increases expression

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; Ro 31-8220 inhibits the reaction [bufalin results in increased expression of IL1B mRNA]; SB 203580 promotes the reaction [bufalin results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation

ISO

bufalin results in decreased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

keratin 18

increases expression

ISO

bufalin results in increased expression of KRT18 protein

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

mitogen activated protein kinase kinase 7

decreases expression

ISO

bufalin results in decreased expression of MAP2K7 protein

NCBI chr12:7,389,032...7,398,377
Ensembl chr12:7,389,155...7,398,377

G

mitogen activated protein kinase kinase kinase 3

decreases expression

ISO

bufalin results in decreased expression of MAP3K3 protein

NCBI chr10:91,519,976...91,588,651
Ensembl chr10:91,519,888...91,588,651

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
decreases activity
increases phosphorylation

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein]
bufalin results in decreased phosphorylation of MAPK1 protein
bufalin results in decreased activity of MAPK1 protein

PMID:10712238 PMID:21922632 PMID:36924737

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
decreases activity
increases phosphorylation

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK3 protein]
bufalin results in decreased phosphorylation of MAPK3 protein
bufalin results in decreased activity of MAPK3 protein

PMID:10712238 PMID:21922632 PMID:36924737

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

decreases activity

ISO

bufalin results in decreased activity of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

decreases activity

ISO

bufalin results in decreased activity of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

bufalin co-treated with osimertinib decreases expression of MCL1 protein in lung
Bufalin decreases expression of MCL1 protein in lung

RGD

PMID:31301315 PMID:28419994

RGD:151356917, RGD:151356918

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

marker of proliferation Ki-67

decreases expression

ISO

bufalin results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 1

decreases expression

ISO

bufalin results in decreased expression of MMP1 protein

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 2

multiple interactions
decreases secretion
decreases expression

ISO

bufalin results in decreased expression of and results in decreased activity of MMP2 protein
bufalin results in decreased secretion of MMP2 protein
bufalin results in decreased expression of MMP2 mRNA

PMID:21922632 PMID:23949904

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases activity
decreases secretion
multiple interactions
decreases expression

ISO

bufalin results in decreased activity of MMP9 protein
bufalin results in decreased secretion of MMP9 protein
bufalin results in decreased expression of and results in decreased activity of MMP9 protein
bufalin results in decreased expression of MMP9 mRNA

PMID:21922632 PMID:23949904

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

bufalin results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nitric oxide synthase 2

decreases expression

ISO

bufalin results in decreased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

bufalin results in increased cleavage of PARP1 protein
bufalin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; HSPB1 protein inhibits the reaction [bufalin results in increased cleavage of PARP1 protein]

PMID:21259053 PMID:23091618

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

inorganic pyrophosphatase 1

decreases expression

ISO

bufalin results in decreased expression of PPA1 protein

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:30,133,504...30,160,489

G

protein phosphatase 2 catalytic subunit beta

decreases expression

ISO

bufalin results in decreased expression of PPP2CB protein

NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634

G

proteasome 20S subunit alpha 3

decreases expression

ISO

bufalin results in decreased expression of PSMA3 protein

NCBI chr 6:95,219,714...95,239,745
Ensembl chr 6:95,219,629...95,241,032

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

bufalin results in decreased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

decreases expression

ISO

bufalin results in decreased expression of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

RELA proto-oncogene, NF-kB subunit

decreases expression
multiple interactions
affects localization

ISO

bufalin results in decreased expression of RELA protein
HSPB1 protein inhibits the reaction [bufalin affects the localization of RELA protein]

PMID:23091618 PMID:23949904

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ras homolog family member A

decreases expression

ISO

bufalin results in decreased expression of RHOA protein

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

ISO

bufalin results in decreased expression of ROCK1 protein

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

ribosomal protein lateral stalk subunit P0

decreases expression

ISO

bufalin results in decreased expression of RPLP0 protein

NCBI chr12:46,715,121...46,718,390
Ensembl chr12:46,715,124...46,718,422

G

ribosomal protein SA

increases expression

ISO

bufalin results in increased expression of RPSA protein

NCBI chr 8:128,728,761...128,732,736
Ensembl chr 8:128,728,862...128,732,737

G

SAP domain containing ribonucleoprotein

increases expression

ISO

bufalin results in increased expression of SARNP protein

NCBI chr 7:1,835,597...1,889,833
Ensembl chr 7:1,835,597...1,897,295

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

ISO

bufalin results in decreased expression of SOS1 protein

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

signal transducer and activator of transcription 3

multiple interactions

ISO

bufalin results in decreased phosphorylation of and results in decreased activity of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

TAR DNA binding protein

decreases expression

ISO

bufalin results in decreased expression of TARDBP protein

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

t-complex 1

decreases expression

ISO

bufalin results in decreased expression of TCP1 protein

NCBI chr 1:50,376,848...50,384,527
Ensembl chr 1:50,376,848...50,384,527

G

tropomodulin 3

decreases expression

ISO

bufalin results in decreased expression of TMOD3 protein

NCBI chr 8:85,131,295...85,191,477
Ensembl chr 8:85,131,299...85,191,341

G

tumor necrosis factor

increases expression
multiple interactions

ISO

bufalin results in increased expression of TNF mRNA
SB 203580 promotes the reaction [bufalin results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 10

multiple interactions

ISO

[chan su results in increased abundance of bufalin] which results in increased susceptibility to TNFSF10 protein; bufalin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]

NCBI chr 2:112,136,550...112,155,903

G

triosephosphate isomerase 1

decreases expression

ISO

bufalin results in decreased expression of TPI1 protein

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tumor protein, translationally-controlled 1

decreases expression

ISO

bufalin results in decreased expression of TPT1 protein

NCBI chr15:57,562,217...57,568,968
Ensembl chr15:57,566,067...57,569,554

G

thymidylate synthetase

decreases expression

ISO

bufalin results in decreased expression of TYMS protein

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

vascular endothelial growth factor A

decreases expression

ISO

bufalin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

decreases expression

ISO

Digitoxigenin results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 4

decreases expression

ISO

Digitoxigenin results in decreased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine ligand 5

decreases expression

ISO

Digitoxigenin results in decreased expression of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

interleukin 6 receptor

decreases expression

ISO

Digitoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

vascular endothelial growth factor A

decreases expression

ISO

Digitoxigenin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ISO

ABCB1 protein results in increased transport of Digoxigenin

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

C-C motif chemokine ligand 2

decreases expression

ISO

Digoxigenin results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 4

decreases expression

ISO

Digoxigenin results in decreased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

ISO

Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

interleukin 17A

multiple interactions

ISO

Digoxigenin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17F

multiple interactions

ISO

Digoxigenin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918

G

interleukin 6 receptor

decreases expression

ISO

Digoxigenin results in decreased expression of IL6R protein modified form

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

neuronal PAS domain protein 2

increases expression
multiple interactions

ISO

Digoxigenin results in increased expression of NPAS2 mRNA
Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

RAR-related orphan receptor C

increases expression
multiple interactions

ISO

Digoxigenin results in increased expression of RORC mRNA
Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

vascular endothelial growth factor A

decreases expression

ISO

Digoxigenin results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

ATM serine/threonine kinase

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

BCL2 associated X, apoptosis regulator

affects localization

ISO

hellebrigenin affects the localization of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

cyclin B1

increases expression

ISO

hellebrigenin results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cell division cycle 25C

decreases phosphorylation

ISO

hellebrigenin results in decreased phosphorylation of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

checkpoint kinase 2

increases phosphorylation

ISO

hellebrigenin results in increased phosphorylation of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

poly (ADP-ribose) polymerase 1

increases activity

ISO

hellebrigenin results in increased activity of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RAR-related orphan receptor C

increases expression

ISO

helveticoside results in increased expression of RORC mRNA

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ISO

oleandrigenin results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity

ISO

oleandrigenin results in increased activity of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

oleandrigenin results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

RB transcriptional corepressor 1

multiple interactions

ISO

oleandrigenin results in decreased phosphorylation of and results in decreased expression of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

tumor protein p53

decreases expression

ISO

oleandrigenin results in decreased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

ISO

oleandrin results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

oleandrin results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

C-X-C motif chemokine receptor 1

increases expression

ISO

oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

C-X-C motif chemokine receptor 2

increases expression

ISO

oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602

G

C-X-C motif chemokine receptor 4

increases expression

ISO

oleandrin results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

ISO

Ouabain affects the expression of A2M protein

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetyl-CoA acyltransferase 2

affects expression

ISO

Ouabain affects the expression of ACAA2 protein

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

angiotensin I converting enzyme

affects expression

EXP

Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

actin alpha 2, smooth muscle

affects expression

ISO

Ouabain affects the expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

ISO

Ouabain affects the expression of ADH1C protein

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

angiotensinogen

affects expression
increases expression

EXP

Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein

PMID:11768735 PMID:16565308

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

decreases expression
affects expression

EXP

Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Ouabain results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

annexin A1

affects expression

ISO

Ouabain affects the expression of ANXA1 protein

NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831

G

annexin A2

affects expression

ISO

Ouabain affects the expression of ANXA2 protein

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

apoptotic peptidase activating factor 1

increases expression

ISO

Ouabain results in increased expression of APAF1 protein

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

ISO

Ouabain results in decreased expression of ARAF mRNA

NCBI chr X:3,780,932...3,845,919
Ensembl chr X:3,780,932...3,792,611

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

ISO

Ouabain results in decreased expression of ARIH1 mRNA

NCBI chr 8:68,673,199...68,775,648
Ensembl chr 8:68,673,200...68,775,572

G

actin related protein 2/3 complex, subunit 5

affects expression

ISO

Ouabain affects the expression of ARPC5 protein

NCBI chr13:67,454,379...67,463,288
Ensembl chr13:67,437,027...67,463,283

G

arrestin, beta 1

increases expression

ISO

Ouabain results in increased expression of ARRB1 mRNA

NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:163,250,157...163,340,859

G

N-acylsphingosine amidohydrolase 1

affects expression

ISO

Ouabain affects the expression of ASAH1 protein

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305

G

activating transcription factor 6 beta

increases expression

ISO

Ouabain results in increased expression of ATF6B protein

NCBI chr20:4,095,534...4,103,534
Ensembl chr20:4,095,534...4,106,032

G

ATM serine/threonine kinase

increases phosphorylation

ISO

Ouabain results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

multiple interactions

ISO
EXP

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]
Ouabain results in decreased activity of [ATP12A protein binds to ATP1B1 protein]

PMID:8853415 PMID:16046397

NCBI chr15:34,559,209...34,583,866
Ensembl chr15:34,559,209...34,583,866

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression
affects expression
affects binding

ISO
EXP

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein

PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding

ISO
EXP

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein

PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More...

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:87,261,968...87,286,911

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
multiple interactions
decreases expression
affects expression
affects binding

ISO
EXP

Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein

PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More...

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:89,700,649...89,729,825

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions
increases expression

EXP

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Ouabain results in decreased activity of [ATP12A protein binds to ATP1B1 protein]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]

PMID:11204457 PMID:16046397

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

ATPase H+/K+ transporting subunit beta

multiple interactions

ISO

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr16:82,846,329...82,855,242
Ensembl chr16:82,846,329...82,855,242

G

ATP synthase F1 subunit alpha

affects expression

ISO

Ouabain affects the expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATR serine/threonine kinase

decreases phosphorylation

ISO

Ouabain results in decreased phosphorylation of ATR protein

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

bromo adjacent homology domain containing 1

decreases expression

ISO

Ouabain results in decreased expression of BAHD1 mRNA

NCBI chr 3:126,341,853...126,368,281
Ensembl chr 3:126,345,371...126,368,278

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

ISO

Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]

PMID:17096883 PMID:18247327 PMID:31436044

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Ouabain results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

Ouabain results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

EXP

Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BRCA1, DNA repair associated

decreases expression

ISO

Ouabain results in decreased expression of BRCA1 protein

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

calbindin 1

decreases expression

EXP

Ouabain results in decreased expression of CALB1 protein

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160

G

calmodulin-like 5

affects expression

ISO

Ouabain affects the expression of CALML5 protein

NCBI chr17:71,304,326...71,305,245
Ensembl chr17:71,304,326...71,305,245

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

ISO

Ouabain results in increased expression of CAMK2B protein

NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485

G

calnexin

increases expression

ISO

Ouabain results in increased expression of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

increases expression
multiple interactions
increases activity

ISO
EXP

Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein

PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

ISO

Ouabain results in increased expression of CASP4 protein

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 8

multiple interactions

ISO

Ouabain results in increased expression of and results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

Ouabain results in increased expression of and results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity

EXP

Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

decreases expression

ISO

Ouabain results in decreased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

coiled-coil domain containing 14

decreases expression

ISO

Ouabain results in decreased expression of CCDC14 mRNA

NCBI chr11:79,557,267...79,593,128
Ensembl chr11:79,557,274...79,593,285

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

EXP

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin A1

decreases expression

ISO

Ouabain results in decreased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin A2

decreases expression

ISO

Ouabain results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin D1

decreases expression

ISO

Ouabain results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cadherin 1

decreases expression
increases expression

ISO

Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 2

decreases expression

ISO

Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin dependent kinase 2

decreases expression

ISO

Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein

PMID:20460749 PMID:21215801 PMID:31436044

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 6

decreases expression

ISO

Ouabain results in decreased expression of CDK6 protein

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

decreases expression
increases expression

ISO

Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein

PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

creatine kinase B

decreases activity

EXP

Ouabain results in decreased activity of CKB protein

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

claudin 1

decreases expression

ISO

Ouabain results in decreased expression of CLDN1 protein

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

canopy FGF signaling regulator 2

affects expression

ISO

Ouabain affects the expression of CNPY2 protein

NCBI chr 7:1,332,293...1,338,081
Ensembl chr 7:1,334,335...1,340,333

G

collagen type I alpha 1 chain

multiple interactions
increases expression

EXP

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

citrate synthase

decreases activity

EXP

Ouabain results in decreased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

cytochrome c-1

multiple interactions

ISO

Ouabain results in decreased expression of and affects the localization of CYC1 protein

NCBI chr 7:109,947,750...109,950,142
Ensembl chr 7:109,947,766...109,950,657

G

DNA-damage inducible transcript 3

increases expression

ISO

Ouabain results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of DDOST mRNA

NCBI chr 5:155,805,612...155,812,728
Ensembl chr 5:155,805,454...155,813,121

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

ISO

Ouabain results in increased expression of DNAJA3 mRNA

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

dopamine receptor D1

multiple interactions
decreases expression

ISO
EXP

Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA

PMID:19626329 PMID:20132239

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

desmoglein 1

affects expression

ISO

Ouabain affects the expression of DSG1 protein

NCBI chr18:11,948,098...11,980,455
Ensembl chr18:11,949,488...11,980,451

G

deoxyuridine triphosphatase

affects expression

ISO

Ouabain affects the expression of DUT protein

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

endothelin converting enzyme 1

increases expression

ISO

Ouabain results in increased expression of ECE1 protein

NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:155,360,639...155,462,719

G

enoyl-CoA hydratase, short chain 1

affects expression

ISO

Ouabain affects the expression of ECHS1 protein

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

endothelin 1

increases expression
decreases expression

EXP
ISO

Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA

PMID:15477225 PMID:28795476

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin receptor type A

increases expression

EXP

Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein

PMID:15477225 PMID:16982439

NCBI chr19:47,137,360...47,207,961
Ensembl chr19:47,137,771...47,201,284

G

epidermal growth factor receptor

decreases phosphorylation

ISO

Ouabain results in decreased phosphorylation of EGFR protein

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

eukaryotic translation initiation factor 2A

increases expression

ISO

Ouabain results in increased expression of EIF2A protein

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 3, subunit K

affects expression

ISO

Ouabain affects the expression of EIF3K protein

NCBI chr 1:93,387,628...93,397,551
Ensembl chr 1:93,387,628...93,397,802

G

endonuclease G

increases expression

ISO

Ouabain results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

ERCC excision repair 4, endonuclease catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of ERCC4 mRNA

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,920,455...2,955,539

G

ETS proto-oncogene 1, transcription factor

decreases expression

ISO

Ouabain results in decreased expression of ETS1 mRNA

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

Fas associated via death domain

increases expression

ISO

Ouabain results in increased expression of FADD protein

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

FA complementation group D2

multiple interactions
decreases expression

ISO

Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group F

decreases expression

ISO

Ouabain results in decreased expression of FANCF mRNA

NCBI chr 1:110,585,054...110,587,870
Ensembl chr 1:110,576,389...110,587,863

G

FA complementation group I

decreases expression
multiple interactions

ISO

Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:142,736,653...142,792,999

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

ISO

Ouabain results in increased expression of FARS2 mRNA

NCBI chr17:28,524,737...28,951,818
Ensembl chr17:28,524,738...28,951,591

G

Fas cell surface death receptor

increases expression

ISO

Ouabain results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

Ouabain results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box protein 32

multiple interactions

ISO

Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]

NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491

G

fumarate hydratase

affects expression

ISO

Ouabain affects the expression of FH protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

FKBP prolyl isomerase 7

increases expression

ISO

Ouabain results in increased expression of FKBP7 mRNA

NCBI chr 3:82,016,647...82,030,913
Ensembl chr 3:82,016,513...82,028,573

G

fibronectin 1

decreases expression

ISO

Ouabain results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

GC, vitamin D binding protein

affects expression

ISO

Ouabain affects the expression of GC protein

NCBI chr14:18,916,255...18,951,670
Ensembl chr14:18,916,246...18,951,673

G

glycine receptor, beta

increases expression

ISO

Ouabain results in increased expression of GLRB mRNA

NCBI chr 2:168,432,736...168,505,614
Ensembl chr 2:168,432,736...168,505,614

G

growth factor receptor bound protein 2

decreases expression

ISO

Ouabain results in decreased expression of GRB2 protein

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutamate ionotropic receptor NMDA type subunit 1

affects expression

EXP

Ouabain affects the expression of GRIN1 protein

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

EXP

Ouabain results in decreased expression of GRIN2A protein

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

EXP

Ouabain results in decreased expression of GRIN2B protein

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

EXP

Ouabain results in decreased expression of GRIN2C protein

NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression

EXP

Ouabain results in increased expression of GRIN2D protein

NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236

G

GTP binding protein 6 (putative)

increases expression

ISO

Ouabain results in increased expression of GTPBP6 mRNA

NCBI chr12:52,234,646...52,238,578
Ensembl chr12:52,234,572...52,238,578

G

H2A.X variant histone

increases phosphorylation

ISO

Ouabain results in increased phosphorylation of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

ISO

Ouabain results in increased expression of HEY1 mRNA

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624

G

hepatocyte growth factor

multiple interactions

EXP

Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
affects localization
increases activity

ISO

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heterogeneous nuclear ribonucleoprotein A2/B1

affects expression

ISO

Ouabain affects the expression of HNRNPA2B1 protein

NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:81,869,661...81,877,572

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

ISO

Ouabain results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,861,716...9,867,945
Ensembl chr14:9,861,716...9,867,945

G

hippocalcin-like 1

affects expression

ISO

Ouabain affects the expression of HPCAL1 protein

NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:46,260,494...46,313,353

G

histidine-rich glycoprotein

affects expression

ISO

Ouabain affects the expression of HRG protein

NCBI chr11:91,559,087...91,573,982
Ensembl chr11:91,559,091...91,573,982

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Ouabain results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family D (Hsp60) member 1

affects expression
multiple interactions

ISO

Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein

PMID:17268060 PMID:18247327

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

inhibitor of DNA binding 2

increases expression

ISO

Ouabain results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

interleukin 2 receptor subunit alpha

decreases expression

ISO

Ouabain results in decreased expression of IL2RA mRNA

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 2 receptor subunit beta

decreases expression

ISO

Ouabain results in decreased expression of IL2RB

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:111,913,828...111,928,537

G

interleukin 6

increases secretion
increases expression

ISO

Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

increases expression

ISO

Ouabain results in increased expression of IL6R mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

integrin-linked kinase

decreases expression

ISO

Ouabain results in decreased expression of ILK mRNA

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

integrin subunit alpha V

decreases expression

ISO

Ouabain results in decreased expression of ITGAV mRNA

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
decreases phosphorylation

ISO

Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily D member 2

increases expression

ISO
EXP

Ouabain results in increased expression of KCND2 mRNA

NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:50,742,839...51,243,522

G

potassium voltage-gated channel subfamily H member 2

decreases expression
decreases activity
multiple interactions

ISO

Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:19139152 PMID:21158687

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

lymphoid enhancer binding factor 1

decreases expression

ISO

Ouabain results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

galectin 1

affects expression
increases expression

ISO

Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein

PMID:17268060 PMID:18247327

NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:112,361,850...112,368,800

G

LIM domain kinase 1

decreases expression

ISO

Ouabain results in decreased expression of LIMK1 mRNA

NCBI chr12:27,663,177...27,697,085
Ensembl chr12:27,663,018...27,697,209

G

lanosterol synthase

increases abundance

ISO

LSS protein results in increased abundance of Ouabain

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

mitogen-activated protein kinase kinase 6

increases expression

ISO

Ouabain results in increased expression of MAP2K6 mRNA

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein

PMID:19687166 PMID:28795476

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

EXP
ISO

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein

PMID:19687166 PMID:28795476

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 7

multiple interactions

ISO

Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein]

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

malate dehydrogenase 2

affects expression

ISO

Ouabain affects the expression of MDH2 protein

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841

G

MDM2 proto-oncogene

multiple interactions

ISO

Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

O-6-methylguanine-DNA methyltransferase

decreases expression

ISO

Ouabain results in decreased expression of MGMT protein

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microRNA 29b-1

multiple interactions
decreases expression

EXP

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA

NCBI chr 4:60,618,334...60,618,414

G

matrix metallopeptidase 13

decreases expression

ISO

Ouabain results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

decreases expression
multiple interactions

ISO

Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

decreases expression

ISO

Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein

PMID:28795476 PMID:33760381

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

muscle RAS oncogene homolog

decreases expression

ISO

Ouabain results in decreased expression of MRAS mRNA

NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911

G

myocardin related transcription factor A

decreases expression

ISO

Ouabain results in decreased expression of MRTFA mRNA

NCBI chr 7:114,424,481...114,594,594
Ensembl chr 7:114,424,481...114,594,594

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

ISO

Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein

PMID:9653513 PMID:21215801

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin light chain 12A

increases expression

ISO

Ouabain results in increased expression of MYL12A protein

NCBI chr 9:118,338,592...118,346,277
Ensembl chr 9:118,338,604...118,342,634

G

myosin light chain kinase

decreases expression

ISO

Ouabain results in decreased expression of MYLK mRNA

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659

G

nectin cell adhesion molecule 3

decreases expression

ISO

Ouabain results in decreased expression of NECTIN3 mRNA

NCBI chr11:67,825,296...67,931,999
Ensembl chr11:67,827,137...67,871,383

G

nectin cell adhesion molecule 4

increases expression

ISO

Ouabain results in increased expression of NECTIN4 mRNA

NCBI chr13:86,335,027...86,354,152
Ensembl chr13:86,335,831...86,353,967

G

neurofilament light chain

decreases expression

ISO

Ouabain results in decreased expression of NEFL mRNA

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

nitric oxide synthase 1

affects expression
increases expression

EXP

Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein

PMID:12384489 PMID:15097235

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 3

multiple interactions
affects expression
increases expression

EXP

5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein

PMID:12384489 PMID:15477225

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NPC intracellular cholesterol transporter 2

decreases expression

ISO

Ouabain results in decreased expression of NPC2 mRNA

NCBI chr 6:110,128,325...110,149,245
Ensembl chr 6:110,128,325...110,150,004

G

natriuretic peptide A

increases expression
multiple interactions

EXP

Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:17266992 PMID:19687166

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

NRAS proto-oncogene, GTPase

decreases expression

ISO

Ouabain results in decreased expression of NRAS mRNA

NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543

G

Parkinsonism associated deglycase

affects response to substance

ISO

PARK7 affects the susceptibility to Ouabain

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]

PMID:24124520 PMID:31436044

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

decreases expression

ISO

Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein

PMID:20460749 PMID:21215801

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 6

increases expression

ISO

Ouabain results in increased expression of PDCD6 protein

NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773

G

prefoldin subunit 5

affects expression

ISO

Ouabain affects the expression of PFDN5 protein

NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:135,330,172...135,335,099

G

profilin 1

affects expression
decreases expression

ISO

Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein

PMID:17268060 PMID:18247327

NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,863,881...55,868,611

G

plasminogen activator, urokinase receptor

decreases expression

ISO

Ouabain results in decreased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase C, gamma 1

decreases expression

ISO

Ouabain results in decreased expression of PLCG1 mRNA

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

palmitoyl-protein thioesterase 2

decreases expression

ISO

Ouabain results in decreased expression of PPT2 mRNA

NCBI chr20:4,117,088...4,137,382
Ensembl chr20:4,127,164...4,137,381

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

ISO

Ouabain results in decreased expression of PRKDC protein

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

proteasome 20S subunit beta 6

affects expression

ISO

Ouabain affects the expression of PSMB6 protein

NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,737,888...55,740,218

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 2

decreases expression

ISO

Ouabain results in decreased expression of PTPN2 mRNA

NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481

G

RAB11B, member RAS oncogene family

increases expression

ISO

Ouabain results in increased expression of RAB11B protein

NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

ISO

Ouabain results in decreased expression of RAF1 mRNA

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RAS protein-specific guanine nucleotide-releasing factor 1

decreases expression

ISO

Ouabain results in decreased expression of RASGRF1 mRNA

NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:99,324,749...99,454,089

G

regulator of G-protein signaling 2

decreases expression

ISO

Ouabain results in decreased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

ras homolog family member H

increases expression

ISO

Ouabain results in increased expression of RHOH mRNA

NCBI chr14:42,694,860...42,725,690
Ensembl chr14:42,693,413...42,749,967

G

Rho-associated coiled-coil containing protein kinase 1

increases cleavage
multiple interactions

ISO

Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]

NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,387,360...1,509,147

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions
increases cleavage

ISO

benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:45,407,965...45,502,771

G

replication protein A3

affects expression

ISO

Ouabain affects the expression of RPA3 protein

NCBI chr 4:37,270,966...37,273,997
Ensembl chr 4:37,270,966...37,274,183

G

Rpgrip1-like

decreases expression

ISO

Ouabain results in decreased expression of RPGRIP1L mRNA

NCBI chr19:31,865,050...31,957,930
Ensembl chr19:31,865,231...31,957,930

G

ribosomal protein S6 kinase B1

affects expression

EXP

Ouabain affects the expression of RPS6KB1 mRNA

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ryanodine receptor 2

multiple interactions
increases response to substance

ISO

K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705

G

S100 calcium binding protein A13

affects expression

ISO

Ouabain affects the expression of S100A13 protein

NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507

G

S100 calcium binding protein B

increases expression

EXP

Ouabain results in increased expression of S100B protein

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression

ISO

Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA

PMID:12590200 PMID:28795476

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

serum/glucocorticoid regulated kinase 2

multiple interactions

ISO

Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]

NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:172,063,776...172,089,011

G

serum/glucocorticoid regulated kinase family, member 3

multiple interactions

ISO

Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium]

NCBI chr 5:14,128,628...14,255,099
Ensembl chr 5:14,126,257...14,198,331

G

SHC adaptor protein 3

increases expression

ISO

Ouabain results in increased expression of SHC3 mRNA

NCBI chr17:13,803,980...13,924,433
Ensembl chr17:13,803,781...13,924,433

G

solute carrier family 16 member 1

multiple interactions

ISO

Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 22 member 12

multiple interactions

ISO

Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380

G

solute carrier family 5 member 5

multiple interactions

ISO

Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

solute carrier family 5 member 6

multiple interactions

ISO

Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:31,039,865...31,051,671
Ensembl chr 6:31,040,017...31,051,670

G

solute carrier family 8 member A1

affects response to substance
increases expression
multiple interactions

ISO
EXP

SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]

PMID:16166162 PMID:19897708

NCBI chr 6:18,975,498...19,299,704
Ensembl chr 6:18,946,798...19,287,964

G

solute carrier family 9 member A1

multiple interactions
increases expression

EXP

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA]

NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517

G

SMAD family member 4

decreases expression

ISO

Ouabain results in decreased expression of SMAD4 mRNA

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684

G

snail family transcriptional repressor 1

decreases expression

ISO

Ouabain results in decreased expression of SNAI1 mRNA

NCBI chr 3:176,667,476...176,671,965

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

ISO

Ouabain results in decreased expression of SOS1 protein

NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

ISO

Ouabain results in decreased expression of SOS2 mRNA

NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811

G

sphingosine kinase 1

decreases expression

ISO

Ouabain results in decreased expression of SPHK1 mRNA

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

G

transforming growth factor, beta 1

decreases expression

ISO

Ouabain results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

decreases expression

ISO

Ouabain results in decreased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

transforming growth factor, beta 3

decreases expression

ISO

Ouabain results in decreased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor beta receptor 3

increases expression

ISO

Ouabain results in increased expression of TGFBR3 mRNA

NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,634,188...2,810,271

G

talin 1

decreases expression

ISO

Ouabain results in decreased expression of TLN1 mRNA

NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687

G

talin 2

decreases expression

ISO

Ouabain results in decreased expression of TLN2 mRNA

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361

G

TNF receptor superfamily member 10b

increases expression

ISO

Ouabain results in increased expression of TNFRSF10A protein

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

tumor protein p53

multiple interactions

ISO

Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

triosephosphate isomerase 1

affects expression

ISO

Ouabain affects the expression of TPI1 protein

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413

G

tumor protein, translationally-controlled 1

affects expression

ISO

Ouabain affects the expression of TPT1 protein

NCBI chr15:57,562,217...57,568,968
Ensembl chr15:57,566,067...57,569,554

G

tripartite motif containing 63

multiple interactions

ISO

[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA

NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

EXP

Ouabain results in increased expression of TRPC1 protein

NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:105,142,931...105,193,826

G

transient receptor potential cation channel, subfamily C, member 6

increases expression
multiple interactions

EXP

Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304

G

twist family bHLH transcription factor 1

increases expression

ISO

Ouabain results in increased expression of TWIST1 mRNA

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

thioredoxin 1

affects expression

ISO

Ouabain affects the expression of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

vimentin

decreases expression

ISO

Ouabain results in decreased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

zinc finger homeobox 3

decreases expression

ISO

Ouabain results in decreased expression of ZFHX3 mRNA

NCBI chr19:52,789,146...53,795,664
Ensembl chr19:53,551,488...53,795,664

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

decreases activity
multiple interactions

EXP

ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

dynamin 1-like

multiple interactions

EXP

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

fragile histidine triad diadenosine triphosphatase

affects expression

ISO

ponasterone A affects the expression of FHIT protein

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621

G

fission, mitochondrial 1

multiple interactions

EXP

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

mitofusin 2

increases expression

EXP

[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

PTEN induced kinase 1

multiple interactions
increases expression

EXP

[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of DNM1L protein; [ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[ponasterone A results in increased expression of PINK1 protein] which results in decreased expression of FIS1 protein]
[ponasterone A results in increased expression of PINK1 protein] which results in increased expression of MFN2 protein; ponasterone A results in increased expression of PINK1 protein

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

EXP

L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

ISO

ponasterone A results in increased expression of UGT1A3 protein

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ISO

ABCB1 protein results in increased transport of Strophanthidin

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

ISO

Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

interleukin 17A

multiple interactions

ISO

Strophanthidin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17F

multiple interactions

ISO

Strophanthidin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918

G

neuronal PAS domain protein 2

increases expression
multiple interactions

ISO

Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

RAR-related orphan receptor C

multiple interactions
increases expression

ISO

RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
molecular entity	20871
polyatomic entity	20745
heteroatomic molecular entity	20606
hydroxides	19922
organic hydroxy compound	19685
hydroxy steroid	14970
14-hydroxy steroid	274
14alpha-hydroxy steroid +	20
14beta-hydroxy steroid +	261
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
organic polycyclic compound	17588
steroid	15237
hydroxy steroid	14970
14-hydroxy steroid	274
14alpha-hydroxy steroid +	20
14beta-hydroxy steroid +	261

paths to the root