|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] |
CTD |
PMID:16904803 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] |
CTD |
PMID:18436619 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
abietic acid results in increased expression of ATF3 mRNA |
CTD |
PMID:27965148 |
|
NCBI chr13:105,274,103...105,331,653
|
|
G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
abietic acid results in increased expression of DNAJB4 mRNA |
CTD |
PMID:27965148 |
|
NCBI chr 2:243,790,296...243,819,042
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
abietic acid results in increased expression of GCLM mRNA |
CTD |
PMID:27965148 |
|
NCBI chr 2:213,032,135...213,052,192
|
|
|
G |
A2m |
alpha-2-macroglobulin |
decreases expression |
ISO |
salvin results in decreased expression of A2M protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:154,897,770...154,947,787
|
|
G |
Aacs |
acetoacetyl-CoA synthetase |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of AACS mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr12:31,113,098...31,156,411
|
|
G |
Abat |
4-aminobutyrate aminotransferase |
increases expression |
ISO |
salvin results in increased expression of ABAT protein |
CTD |
PMID:35926579 |
|
NCBI chr10:7,503,351...7,599,474
|
|
G |
Abca6 |
ATP binding cassette subfamily A member 6 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of ABCA6 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr10:95,142,805...95,212,087
|
|
G |
Abhd11 |
abhydrolase domain containing 11 |
increases expression |
ISO |
salvin results in increased expression of ABHD11 protein |
CTD |
PMID:35926579 |
|
NCBI chr12:27,318,739...27,322,016
|
|
G |
Abi1 |
abl-interactor 1 |
increases expression |
ISO |
salvin results in increased expression of ABI1 protein |
CTD |
PMID:35926579 |
|
NCBI chr17:85,098,837...85,179,829
|
|
G |
Acly |
ATP citrate lyase |
increases expression |
ISO |
salvin results in increased expression of ACLY protein |
CTD |
PMID:35926579 |
|
NCBI chr10:85,412,045...85,464,253
|
|
G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
increases expression |
ISO |
salvin results in increased expression of ACSS2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:144,003,808...144,047,452
|
|
G |
Actn1 |
actinin, alpha 1 |
increases expression |
ISO |
salvin results in increased expression of ACTN1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:104,731,485...104,826,312
|
|
G |
Adcy9 |
adenylate cyclase 9 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADCY9 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr10:11,645,373...11,768,462
|
|
G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 9:2,329,398...2,484,959
|
|
G |
Adgre4 |
adhesion G protein-coupled receptor E4 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE4 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 9:9,758,106...9,901,908
|
|
G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
increases expression |
ISO |
salvin results in increased expression of ADH1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:226,797,303...226,808,892
|
|
G |
Aebp1 |
AE binding protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of AEBP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr14:80,738,800...80,748,878
|
|
G |
Agps |
alkylglycerone phosphate synthase |
decreases expression |
ISO |
salvin results in decreased expression of AGPS protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:60,747,323...60,845,831
|
|
G |
Ahsg |
alpha-2-HS-glycoprotein |
decreases expression |
ISO |
salvin results in decreased expression of AHSG protein |
CTD |
PMID:35926579 |
|
NCBI chr11:78,121,388...78,127,998
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation decreases phosphorylation |
ISO |
salvin results in increased phosphorylation of AKT1 protein salvin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:25178877 PMID:25271104 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Alb |
albumin |
decreases expression |
ISO |
salvin results in decreased expression of ALB protein |
CTD |
PMID:35926579 |
|
NCBI chr14:17,891,564...17,907,043
|
|
G |
Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
decreases expression |
ISO |
salvin results in decreased expression of ALDH1A3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:119,982,272...120,017,416
|
|
G |
Amy2a1 |
amylase 2a1 |
decreases expression |
ISO |
salvin results in decreased expression of AMY2A1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:201,344,912...201,353,500
|
|
G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] |
CTD |
PMID:29854073 |
|
NCBI chr 7:27,381,392...27,466,772
|
|
G |
Apoa1 |
apolipoprotein A1 |
decreases expression |
ISO |
salvin results in decreased expression of APOA1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:55,423,945...55,425,729
|
|
G |
Apoa4 |
apolipoprotein A4 |
decreases expression |
ISO |
salvin results in decreased expression of APOA4 protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:55,435,779...55,438,160
|
|
G |
Apoe |
apolipoprotein E |
decreases expression |
ISO |
salvin results in decreased expression of APOE protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:88,481,889...88,485,816
|
|
G |
Apoh |
apolipoprotein H |
decreases expression |
ISO |
salvin results in decreased expression of APOH protein |
CTD |
PMID:35926579 |
|
NCBI chr10:93,342,435...93,356,334
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
decreases expression |
ISO |
salvin results in decreased expression of ASNS protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:36,752,061...36,769,970
|
|
G |
Aspa |
aspartoacylase |
decreases expression |
ISO |
salvin results in decreased expression of ASPA protein |
CTD |
PMID:35926579 |
|
NCBI chr10:57,891,704...57,945,267
|
|
G |
Aspn |
asporin |
increases expression |
ISO |
salvin results in increased expression of ASPN protein |
CTD |
PMID:35926579 |
|
NCBI chr17:15,079,910...15,104,369
|
|
G |
Atp12a |
ATPase H+/K+ transporting non-gastric alpha2 subunit |
increases expression |
ISO |
salvin results in increased expression of ATP12A protein |
CTD |
PMID:35926579 |
|
NCBI chr15:30,443,571...30,468,229
|
|
G |
B2m |
beta-2 microglobulin |
increases expression |
ISO |
salvin results in increased expression of B2M protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:129,549,236...129,555,354
|
|
G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions increases expression decreases phosphorylation |
ISO |
salvin promotes the reaction [arsenic trioxide results in decreased phosphorylation of BAD protein] salvin results in increased expression of BAD protein salvin results in decreased phosphorylation of BAD protein |
CTD |
PMID:23239002 PMID:28918123 |
|
NCBI chr 1:213,562,719...213,572,034
|
|
G |
Basp1 |
brain abundant, membrane attached signal protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of BASP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:77,546,628...77,594,297
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein] salvin results in increased expression of BAX protein salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein] |
CTD |
PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bcas2 |
BCAS2, pre-mRNA processing factor |
decreases expression |
ISO |
salvin results in decreased expression of BCAS2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:190,692,503...190,700,386
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein] salvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] |
CTD |
PMID:25446857 PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 PMID:30707903 More...
|
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bcl2l2 |
Bcl2-like 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein] |
CTD |
PMID:24557422 |
|
NCBI chr15:28,346,449...28,361,627
|
|
G |
Bmp5 |
bone morphogenetic protein 5 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of BMP5 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 8:76,517,164...76,639,925
|
|
G |
Bzw2 |
basic leucine zipper and W2 domains 2 |
decreases expression |
ISO |
salvin results in decreased expression of BZW2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:52,828,069...52,888,599
|
|
G |
C3 |
complement C3 |
decreases expression |
ISO |
salvin results in decreased expression of C3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:2,174,412...2,201,339
|
|
G |
C4b |
complement C4B |
decreases expression |
ISO |
salvin results in decreased expression of C4B protein |
CTD |
PMID:35926579 |
|
NCBI chr20:4,197,371...4,211,684
|
|
G |
Camp |
cathelicidin antimicrobial peptide |
decreases expression |
ISO |
salvin results in decreased expression of CAMP protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:109,841,729...109,843,543
|
|
G |
Car2 |
carbonic anhydrase 2 |
increases expression |
ISO |
salvin results in increased expression of CA2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:88,462,883...88,478,012
|
|
G |
Casp14 |
caspase 14 |
increases expression |
ISO |
salvin results in increased expression of CASP14 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:10,929,759...10,932,591
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein] salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein] |
CTD |
PMID:24557422 PMID:25271104 PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 PMID:29854073 PMID:30707903 PMID:31705926 More...
|
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
salvin results in decreased expression of CASP6 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:221,140,287...221,152,727
|
|
G |
Casp8 |
caspase 8 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein] salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein] |
CTD |
PMID:28918123 PMID:29854073 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Casp9 |
caspase 9 |
increases activity multiple interactions increases cleavage |
ISO |
salvin results in increased activity of CASP9 protein salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein] salvin results in increased cleavage of CASP9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP9 mRNA]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]; salvin promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein] |
CTD |
PMID:23239002 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 PMID:29854073 More...
|
|
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
salvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA] salvin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] |
CTD |
PMID:28159594 PMID:29854073 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
[salvin co-treated with Tretinoin] results in increased expression of CD14 protein; salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein] |
CTD |
PMID:11504768 |
|
NCBI chr18:28,609,558...28,611,409
|
|
G |
Cd177 |
CD177 molecule |
decreases expression |
ISO |
salvin results in decreased expression of CD177 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:80,340,034...80,360,599
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions |
ISO |
salvin results in increased expression of CDKN1B protein salvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein] |
CTD |
PMID:23239002 |
|
NCBI chr 4:169,491,273...169,496,500
|
|
G |
Cela1 |
chymotrypsin like elastase 1 |
decreases expression |
ISO |
salvin results in decreased expression of CELA1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:131,773,161...131,786,300
|
|
G |
Cela3b |
chymotrypsin like elastase 3B |
decreases expression |
ISO |
salvin results in decreased expression of CELA3B protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:149,628,773...149,636,937
|
|
G |
Chp2 |
calcineurin-like EF hand protein 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of CHP2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:186,189,090...186,203,663
|
|
G |
Ckmt1 |
creatine kinase, mitochondrial 1 |
increases expression |
ISO |
salvin results in increased expression of CKMT1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:128,783,408...128,789,485
|
|
G |
Clca1 |
chloride channel accessory 1 |
increases expression |
ISO |
salvin results in increased expression of CLCA1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:233,938,677...233,964,369
|
|
G |
Clca4 |
chloride channel accessory 4 |
decreases expression |
ISO |
salvin results in decreased expression of CLCA4A protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:233,883,625...233,904,993
|
|
G |
Clec14a |
C-type lectin domain containing 14A |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of CLEC14A mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 6:75,881,470...75,884,612
|
|
G |
Clic5 |
chloride intracellular channel 5 |
increases expression |
ISO |
salvin results in increased expression of CLIC5 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:16,710,980...16,813,502
|
|
G |
Clns1a |
chloride nucleotide-sensitive channel 1A |
increases expression |
ISO |
salvin results in increased expression of CLNS1A protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:152,019,369...152,039,670
|
|
G |
Clu |
clusterin |
decreases expression |
ISO |
salvin results in decreased expression of CLU protein |
CTD |
PMID:35926579 |
|
NCBI chr15:40,161,068...40,200,315
|
|
G |
Col18a1 |
collagen type XVIII alpha 1 chain |
decreases expression |
ISO |
salvin results in decreased expression of COL18A1 protein |
CTD |
PMID:35926579 |
|
NCBI chr20:11,474,104...11,582,593
|
|
G |
Col6a3 |
collagen type VI alpha 3 chain |
decreases expression |
ISO |
salvin results in decreased expression of COL6A3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:98,809,171...98,887,060
|
|
G |
Cox6a1 |
cytochrome c oxidase subunit 6A1 |
increases expression |
ISO |
salvin results in increased expression of COX6A1 protein |
CTD |
PMID:35926579 |
|
NCBI chr12:41,261,983...41,265,037
|
|
G |
Cp |
ceruloplasmin |
decreases expression |
ISO |
salvin results in decreased expression of CP protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:104,368,336...104,427,119
|
|
G |
Cpb1 |
carboxypeptidase B1 |
decreases expression |
ISO |
salvin results in decreased expression of CPB1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:102,755,241...102,785,628
|
|
G |
Cpox |
coproporphyrinogen oxidase |
increases expression |
ISO |
salvin results in increased expression of CPOX protein |
CTD |
PMID:35926579 |
|
NCBI chr11:41,936,585...41,946,568
|
|
G |
Cpsf7 |
cleavage and polyadenylation specific factor 7 |
decreases expression |
ISO |
salvin results in decreased expression of CPSF7 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:216,592,745...216,616,860
|
|
G |
Crnkl1 |
crooked neck pre-mRNA splicing factor 1 |
decreases expression |
ISO |
salvin results in decreased expression of CRNKL1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:133,338,593...133,354,329
|
|
G |
Ctrl |
chymotrypsin-like |
decreases expression |
ISO |
salvin results in decreased expression of CTRB1 protein |
CTD |
PMID:35926579 |
|
NCBI chr19:33,827,279...33,829,129
|
|
G |
Cybb |
cytochrome b-245 beta chain |
decreases expression |
ISO |
salvin results in decreased expression of CYBB protein |
CTD |
PMID:35926579 |
|
NCBI chr X:16,030,596...16,065,065
|
|
G |
Cyp20a1 |
cytochrome P450, family 20, subfamily a, polypeptide 1 |
decreases expression |
ISO |
salvin results in decreased expression of CYP20A1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:61,755,804...61,805,123
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP2B10 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:90,780,468...90,859,852
|
|
G |
Cyp2c66 |
cytochrome P450, family 2, subfamily c, polypeptide 66 |
decreases expression |
ISO |
salvin results in decreased expression of CYP2C66 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:246,490,888...246,582,199
|
|
G |
Cyp51 |
cytochrome P450, family 51 |
decreases expression |
ISO |
salvin results in decreased expression of CYP51A1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:30,036,956...30,055,410
|
|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP7A1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 5:24,174,505...24,184,202
|
|
G |
Dmbt1 |
deleted in malignant brain tumors 1 |
decreases expression |
ISO |
salvin results in decreased expression of DMBT1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:185,617,469...185,696,476
|
|
G |
Dnajc10 |
DnaJ heat shock protein family (Hsp40) member C10 |
decreases expression |
ISO |
salvin results in decreased expression of DNAJC10 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:65,232,031...65,272,732
|
|
G |
Dop1b |
DOP1 leucine zipper like protein B |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of DOP1B mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr11:33,024,376...33,125,931
|
|
G |
Dpep1 |
dipeptidase 1 |
decreases expression |
ISO |
salvin results in decreased expression of DPEP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr19:51,209,831...51,237,004
|
|
G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of EHHADH mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr11:79,241,927...79,275,173
|
|
G |
Elane |
elastase, neutrophil expressed |
decreases expression |
ISO |
salvin results in decreased expression of ELANE protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:9,817,251...9,819,174
|
|
G |
Eno3 |
enolase 3 |
increases expression |
ISO |
salvin results in increased expression of ENO3 protein |
CTD |
PMID:35926579 |
|
NCBI chr10:55,370,531...55,375,921
|
|
G |
Fabp1 |
fatty acid binding protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of FABP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:104,744,302...104,753,119
|
|
G |
Fabp5 |
fatty acid binding protein 5 |
decreases expression |
ISO |
salvin results in decreased expression of FABP5 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:91,765,056...91,768,716
|
|
G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of FAS protein] |
CTD |
PMID:29854073 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Fbln2 |
fibulin 2 |
decreases expression |
ISO |
salvin results in decreased expression of FBLN2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:123,704,289...123,763,857
|
|
G |
Fen1 |
flap structure-specific endonuclease 1 |
decreases expression |
ISO |
salvin results in decreased expression of FEN1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:216,270,016...216,274,873
|
|
G |
Fga |
fibrinogen alpha chain |
decreases expression |
ISO |
salvin results in decreased expression of FGA protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:170,672,169...170,679,572
|
|
G |
Fgb |
fibrinogen beta chain |
decreases expression |
ISO |
salvin results in decreased expression of FGB protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:168,394,901...168,402,863
|
|
G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of FGF21 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:105,219,825...105,221,376
|
|
G |
Fgg |
fibrinogen gamma chain |
decreases expression |
ISO |
salvin results in decreased expression of FGG protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:168,354,880...168,362,325
|
|
G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein] |
CTD |
PMID:31705926 |
|
NCBI chr12:25,345,239...25,360,135
|
|
G |
Fmo2 |
flavin containing dimethylaniline monoxygenase 2 |
increases expression |
ISO |
salvin results in increased expression of FMO2 protein |
CTD |
PMID:35926579 |
|
NCBI chr13:75,221,149...75,244,377
|
|
G |
Fscn1 |
fascin actin-bundling protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of FSCN1 protein |
CTD |
PMID:35926579 |
|
NCBI chr12:16,710,601...16,723,734
|
|
G |
Galnt12 |
polypeptide N-acetylgalactosaminyltransferase 12 |
decreases expression |
ISO |
salvin results in decreased expression of GALNT12 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:61,384,575...61,413,346
|
|
G |
Galnt3 |
polypeptide N-acetylgalactosaminyltransferase 3 |
decreases expression |
ISO |
salvin results in decreased expression of GALNT3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:71,150,559...71,187,321
|
|
G |
Garre1 |
granule associated Rac and RHOG effector 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of GARRE1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:86,862,121...86,939,725
|
|
G |
Gc |
GC, vitamin D binding protein |
decreases expression |
ISO |
salvin results in decreased expression of GC protein |
CTD |
PMID:35926579 |
|
NCBI chr14:18,632,146...18,667,563
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO EXP |
salvin results in increased expression of GCLC mRNA salvin results in increased expression of GCLC protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein] |
CTD |
PMID:18329808 PMID:25446857 PMID:26577515 PMID:26686574 |
|
NCBI chr 8:87,510,251...87,548,896
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein] salvin results in increased expression of GCLM protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein] |
CTD |
PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594 |
|
NCBI chr 2:213,032,135...213,052,192
|
|
G |
Gcnt3 |
glucosaminyl (N-acetyl) transferase 3, mucin type |
decreases expression |
ISO |
salvin results in decreased expression of GCNT3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:70,689,173...70,696,476
|
|
G |
Gfer |
growth factor, augmenter of liver regeneration |
increases expression |
ISO |
salvin results in increased expression of GFER protein |
CTD |
PMID:35926579 |
|
NCBI chr10:13,718,489...13,721,782
|
|
G |
Ggh |
gamma-glutamyl hydrolase |
increases expression |
ISO |
salvin results in increased expression of GGH protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:33,529,880...33,552,790
|
|
G |
Glod5 |
glyoxalase domain containing 5 |
increases expression |
ISO |
salvin results in increased expression of GLOD5 protein |
CTD |
PMID:35926579 |
|
NCBI chr X:14,473,994...14,488,797
|
|
G |
Gnl3 |
G protein nucleolar 3 |
decreases expression |
ISO |
salvin results in decreased expression of GNL3 protein |
CTD |
PMID:35926579 |
|
NCBI chr16:6,207,402...6,213,491
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of GPT protein] |
CTD |
PMID:29854073 PMID:35202923 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA] |
CTD |
PMID:28159594 |
|
NCBI chr 8:117,905,462...117,906,588
|
|
G |
Grn |
granulin precursor |
decreases expression |
ISO |
salvin results in decreased expression of GRN protein |
CTD |
PMID:35926579 |
|
NCBI chr10:87,387,672...87,393,777
|
|
G |
Gsdme |
gasdermin E |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of GSDME mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 4:79,258,799...79,321,129
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions increases expression |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein] salvin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] salvin results in increased expression of GSR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein] |
CTD |
PMID:25446857 PMID:26577515 PMID:26686574 PMID:29854073 |
|
NCBI chr16:65,185,574...65,228,742
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein] salvin results in increased expression of GSTP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]; salvin results in increased expression of and results in increased activity of GSTP1 protein |
CTD |
PMID:25271104 PMID:26577515 |
|
NCBI chr 1:210,767,237...210,770,242
|
|
G |
Gtf2f1 |
general transcription factor IIF subunit 1 |
decreases expression |
ISO |
salvin results in decreased expression of GTF2F1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:1,931,033...1,940,197
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
ISO |
salvin results in decreased expression of HMGCS2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:185,875,609...185,903,505
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
salvin results in increased expression of HMOX1 mRNA; salvin results in increased expression of HMOX1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein] |
CTD |
PMID:18329808 PMID:23942037 PMID:26686574 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hnrnpa3 |
heterogeneous nuclear ribonucleoprotein A3 |
decreases expression |
ISO |
salvin results in decreased expression of HNRNPA3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:60,578,574...60,588,755
|
|
G |
Hp |
haptoglobin |
decreases expression |
ISO |
salvin results in decreased expression of HP protein |
CTD |
PMID:35926579 |
|
NCBI chr19:54,449,151...54,453,701
|
|
G |
Hpx |
hemopexin |
decreases expression |
ISO |
salvin results in decreased expression of HPX protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:159,932,819...159,940,327
|
|
G |
Hsd17b6 |
hydroxysteroid (17-beta) dehydrogenase 6 |
decreases expression |
ISO |
salvin results in decreased expression of HSD17B6 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:422,466...442,008
|
|
G |
Id3 |
inhibitor of DNA binding 3 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of ID3 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 5:153,656,253...153,657,860
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] |
CTD |
PMID:23942037 |
|
NCBI chr 7:55,789,180...55,793,216
|
|
G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
decreases expression |
ISO |
salvin results in decreased expression of IGFBP7 protein |
CTD |
PMID:35926579 |
|
NCBI chr14:30,737,414...30,797,317
|
|
G |
Igkvl-ps13 |
immunoglobulin kappa variable like, pseudogene 13 |
decreases expression |
ISO |
salvin results in decreased expression of IGKV1-133 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:96,968,574...96,969,477
|
|
G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions increases ubiquitination |
ISO |
PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein] |
CTD |
PMID:31705926 |
|
NCBI chr X:157,358,279...157,397,563
|
|
G |
Inhbe |
inhibin subunit beta E |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of INHBE mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 7:65,061,531...65,064,519
|
|
G |
Inmt |
indolethylamine N-methyltransferase |
increases expression |
ISO |
salvin results in increased expression of INMT protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:84,318,197...84,322,493
|
|
G |
Ints3 |
integrator complex subunit 3 |
decreases expression |
ISO |
salvin results in decreased expression of INTS3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:175,859,421...175,911,683
|
|
G |
Itga2 |
integrin subunit alpha 2 |
decreases expression |
ISO |
salvin results in decreased expression of ITGA2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:46,520,345...46,621,487
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions decreases expression |
ISO |
[salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; salvin promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; salvin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] salvin results in decreased expression of ITGAM protein |
CTD |
PMID:11504768 PMID:35926579 |
|
NCBI chr 1:192,089,496...192,139,947
|
|
G |
Itgb2 |
integrin subunit beta 2 |
decreases expression |
ISO |
salvin results in decreased expression of ITGB2 protein |
CTD |
PMID:35926579 |
|
NCBI chr20:11,061,009...11,097,242
|
|
G |
Klf12 |
KLF transcription factor 12 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of KLF12 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr15:83,037,548...83,469,998
|
|
G |
Kng1 |
kininogen 1 |
decreases expression |
ISO |
salvin results in decreased expression of KNG1 protein |
CTD |
PMID:35926579 |
|
NCBI chr11:77,812,757...77,835,555
|
|
G |
Lamp2 |
lysosomal-associated membrane protein 2 |
decreases expression |
ISO |
salvin results in decreased expression of LAMP2 protein |
CTD |
PMID:35926579 |
|
NCBI chr X:122,038,734...122,087,745
|
|
G |
Lcn2 |
lipocalin 2 |
decreases expression |
ISO |
salvin results in decreased expression of LCN2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:36,078,432...36,081,851
|
|
G |
Lgals2 |
galectin 2 |
decreases expression |
ISO |
salvin results in decreased expression of LGALS2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:112,283,630...112,290,228
|
|
G |
Lgals3bp |
galectin 3 binding protein |
decreases expression |
ISO |
salvin results in decreased expression of LGALS3BP protein |
CTD |
PMID:35926579 |
|
NCBI chr10:103,619,912...103,629,251
|
|
G |
Lgals9 |
galectin 9 |
decreases expression |
ISO |
salvin results in decreased expression of LGALS9 protein |
CTD |
PMID:35926579 |
|
NCBI chr10:64,405,044...64,428,249
|
|
G |
Lgmn |
legumain |
decreases expression |
ISO |
salvin results in decreased expression of LGMN protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:121,544,048...121,582,495
|
|
G |
Ltf |
lactotransferrin |
decreases expression |
ISO |
salvin results in decreased expression of LTF protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:110,999,948...111,022,795
|
|
G |
Luzp1 |
leucine zipper protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of LUZP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:148,706,094...148,781,616
|
|
G |
Lyve1 |
lymphatic vessel endothelial hyaluronan receptor 1 |
increases expression |
ISO |
salvin results in increased expression of LYVE1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:164,962,872...164,976,309
|
|
G |
Lyz2 |
lysozyme 2 |
decreases expression |
ISO |
salvin results in decreased expression of LYZ2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:52,906,810...52,912,154
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein] salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:25446857 PMID:29854073 |
|
NCBI chr16:8,645,171...8,728,225
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:25446857 |
|
NCBI chr10:34,670,750...34,711,972
|
|
G |
Marcksl1 |
MARCKS-like 1 |
decreases expression |
ISO |
salvin results in decreased expression of MARCKSL1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:147,135,827...147,138,150
|
|
G |
Mcm7 |
minichromosome maintenance complex component 7 |
decreases expression |
ISO |
salvin results in decreased expression of MCM7 protein |
CTD |
PMID:35926579 |
|
NCBI chr12:22,155,921...22,163,320
|
|
G |
Mfn2 |
mitofusin 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein] |
CTD |
PMID:31705926 |
|
NCBI chr 5:158,304,285...158,335,502
|
|
G |
Mov10 |
Mov10 RNA helicase |
decreases expression |
ISO |
salvin results in decreased expression of MOV10 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:192,292,041...192,315,142
|
|
G |
Mpo |
myeloperoxidase |
decreases expression |
ISO |
salvin results in decreased expression of MPO protein |
CTD |
PMID:35926579 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Mpzl2 |
myelin protein zero-like 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of MPZL2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 8:54,244,920...54,256,064
|
|
G |
Mrps31 |
mitochondrial ribosomal protein S31 |
decreases expression |
ISO |
salvin results in decreased expression of MRPS31 protein |
CTD |
PMID:35926579 |
|
NCBI chr16:69,601,349...69,621,609
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
salvin results in decreased phosphorylation of MTOR protein |
CTD |
PMID:25178877 PMID:28918123 |
|
NCBI chr 5:164,167,985...164,277,438
|
|
G |
Mug1 |
murinoglobulin 1 |
decreases expression |
ISO |
salvin results in decreased expression of MUG1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:155,076,270...155,130,051
|
|
G |
Mug2 |
murinoglobulin 2 |
decreases expression |
ISO |
salvin results in decreased expression of MUG2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:155,164,061...155,236,894
|
|
G |
Mylip |
myosin regulatory light chain interacting protein |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of MYLIP mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr17:19,286,649...19,308,295
|
|
G |
Myo1b |
myosin Ib |
decreases expression |
ISO |
salvin results in decreased expression of MYO1B protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:49,690,043...49,852,373
|
|
G |
Ndst1 |
N-deacetylase and N-sulfotransferase 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of NDST1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr18:54,136,887...54,199,545
|
|
G |
Ndufa12 |
NADH:ubiquinone oxidoreductase subunit A12 |
increases expression |
ISO |
salvin results in increased expression of NDUFA12 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:28,771,330...28,798,316
|
|
G |
Nelfb |
negative elongation factor complex member B |
decreases expression |
ISO |
salvin results in decreased expression of NELFB protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:28,409,045...28,425,564
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases activity multiple interactions |
ISO |
salvin results in increased activity of NFE2L2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin affects the localization of and results in increased activity of NFE2L2 protein; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 mRNA]; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein] |
CTD |
PMID:26577515 PMID:26686574 PMID:28159594 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
salvin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; salvin results in increased phosphorylation of and results in increased degradation of NFKBIA protein |
CTD |
PMID:21375325 PMID:25271104 PMID:29854073 |
|
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Nlrp12 |
NLR family, pyrin domain containing 12 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of NLRP12 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:65,932,610...65,969,873
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:21375325 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nox1 |
NADPH oxidase 1 |
decreases expression |
ISO |
salvin results in decreased expression of NOX1 protein |
CTD |
PMID:35926579 |
|
NCBI chr X:97,279,058...97,332,291
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
salvin results in increased expression of NQO1 mRNA salvin results in increased expression of NQO1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA] |
CTD |
PMID:18329808 PMID:26686574 PMID:28159594 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of NR3C2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr19:47,619,853...47,964,089
|
|
G |
Nrdc |
nardilysin convertase |
decreases expression |
ISO |
salvin results in decreased expression of NRDC protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:123,755,807...123,818,910
|
|
G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
increases expression |
ISO |
salvin results in increased expression of OAS1G protein |
CTD |
PMID:35926579 |
|
NCBI chr12:35,669,798...35,680,505
|
|
G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
multiple interactions increases expression |
ISO |
OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein] |
CTD |
PMID:31705926 |
|
NCBI chr11:84,612,943...84,690,025
|
|
G |
Orm1 |
orosomucoid 1 |
decreases expression |
ISO |
salvin results in decreased expression of ORM1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:81,788,509...81,791,661
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage decreases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] salvin results in decreased expression of PARP1 protein |
CTD |
PMID:25446857 PMID:28918123 PMID:30707903 PMID:31705926 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pcbd2 |
pterin-4 alpha-carbinolamine dehydratase 2 |
increases expression |
ISO |
salvin results in increased expression of PCBD2 protein |
CTD |
PMID:35926579 |
|
NCBI chr17:8,845,161...8,896,343
|
|
G |
Pde5a |
phosphodiesterase 5A |
increases expression |
ISO |
salvin results in increased expression of PDE5A protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:210,858,515...211,003,480
|
|
G |
Pdxk |
pyridoxal kinase |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of PDXK mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr20:10,209,975...10,232,012
|
|
G |
Per2 |
period circadian regulator 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of PER2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 9:99,454,828...99,497,069
|
|
G |
Pgam5 |
PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
decreases expression |
ISO |
salvin results in decreased expression of PGAM5 protein |
CTD |
PMID:35926579 |
|
NCBI chr12:52,069,023...52,076,131
|
|
G |
Pglyrp1 |
peptidoglycan recognition protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of PGLYRP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:78,531,815...78,537,001
|
|
G |
Phgdh |
phosphoglycerate dehydrogenase |
decreases expression |
ISO |
salvin results in decreased expression of PHGDH protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:185,906,962...185,936,054
|
|
G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein] |
CTD |
PMID:30707903 |
|
NCBI chr 5:155,813,838...155,825,950
|
|
G |
Plg |
plasminogen |
decreases expression |
ISO |
salvin results in decreased expression of PLG protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:48,325,186...48,367,643
|
|
G |
Plin2 |
perilipin 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of PLIN2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 5:106,202,634...106,258,748
|
|
G |
Plin4 |
perilipin 4 |
increases expression |
ISO |
salvin results in increased expression of PLIN4 protein |
CTD |
PMID:35926579 |
|
NCBI chr 9:929,168...938,062
|
|
G |
Plpp1 |
phospholipid phosphatase 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of PLPP1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 2:46,172,202...46,233,632
|
|
G |
Pnlip |
pancreatic lipase |
decreases expression |
ISO |
salvin results in decreased expression of PNLIP protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:257,774,012...257,811,656
|
|
G |
Pnliprp1 |
pancreatic lipase-related protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of PNLIPRP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:257,867,885...257,883,514
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases activity |
ISO |
salvin results in increased activity of PPARG protein |
CTD |
PMID:20696231 |
|
NCBI chr 4:150,095,743...150,221,104
|
|
G |
Prdx6 |
peroxiredoxin 6 |
increases expression |
ISO |
salvin results in increased expression of PRDX6 protein |
CTD |
PMID:35926579 |
|
NCBI chr13:73,528,746...73,539,295
|
|
G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions increases expression |
ISO |
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein] salvin results in increased expression of PRKN protein |
CTD |
PMID:30707903 PMID:31705926 |
|
NCBI chr 1:51,236,410...52,430,242
|
|
G |
Prom1 |
prominin 1 |
decreases expression |
ISO |
salvin results in decreased expression of PROM1 protein |
CTD |
PMID:35926579 |
|
NCBI chr14:71,202,303...71,307,008
|
|
G |
Pten |
phosphatase and tensin homolog |
multiple interactions increases expression |
ISO |
salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA] salvin results in increased expression of PTEN mRNA |
CTD |
PMID:23239002 |
|
NCBI chr 1:240,043,707...240,110,330
|
|
G |
Ptgds |
prostaglandin D2 synthase |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of PTGDS mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 3:28,680,044...28,682,978
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:21375325 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Pvalb |
parvalbumin |
decreases expression |
ISO |
salvin results in decreased expression of PVALB protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:111,653,820...111,668,469
|
|
G |
Pxdn |
peroxidasin |
decreases expression |
ISO |
salvin results in decreased expression of PXDN protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:46,580,749...46,658,345
|
|
G |
Qsox1 |
quiescin sulfhydryl oxidase 1 |
decreases expression |
ISO |
salvin results in decreased expression of QSOX1 protein |
CTD |
PMID:35926579 |
|
NCBI chr13:67,949,780...67,987,434
|
|
G |
Rab11fip2 |
RAB11 family interacting protein 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of RAB11FIP2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:268,908,825...269,080,691
|
|
G |
Rapgef5 |
Rap guanine nucleotide exchange factor 5 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of RAPGEF5 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 6:138,445,184...138,679,943
|
|
G |
Rara |
retinoic acid receptor, alpha |
multiple interactions |
ISO |
[Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein |
CTD |
PMID:11504768 |
|
NCBI chr10:83,883,490...83,928,932
|
|
G |
Rbpms |
RNA binding protein, mRNA processing factor |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of RBPMS mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr16:58,239,370...58,395,424
|
|
G |
Rdh9 |
retinol dehydrogenase 9 |
decreases expression |
ISO |
salvin results in decreased expression of RDH9 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:63,642,305...63,645,149
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases expression affects localization |
ISO |
salvin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of RELA protein] salvin results in increased expression of RELA protein salvin affects the localization of RELA protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; salvin results in increased expression of and results in increased activity of RELA protein |
CTD |
PMID:21375325 PMID:25271104 PMID:29854073 PMID:31705926 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Rer1 |
retention in endoplasmic reticulum sorting receptor 1 |
increases expression |
ISO |
salvin results in increased expression of RER1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:170,916,643...170,929,073
|
|
G |
Rheb |
Ras homolog, mTORC1 binding |
decreases expression |
ISO |
salvin results in decreased expression of RHEB protein |
CTD |
PMID:35926579 |
|
NCBI chr 4:11,012,173...11,053,860
|
|
G |
Rnase4 |
ribonuclease A family member 4 |
decreases expression |
ISO |
salvin results in decreased expression of RNASE4 protein |
CTD |
PMID:35926579 |
|
NCBI chr15:26,786,287...26,803,634
|
|
G |
Rpa1 |
replication protein A1 |
decreases expression |
ISO |
salvin results in decreased expression of RPA1 protein |
CTD |
PMID:35926579 |
|
NCBI chr10:60,647,185...60,698,279
|
|
G |
Rps21-ps1 |
ribosomal protein S21, pseudogene 1 |
increases expression |
ISO |
salvin results in increased expression of RPS21 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:153,387,133...153,387,476
|
|
G |
Rxra |
retinoid X receptor alpha |
increases expression multiple interactions |
ISO |
salvin results in increased expression of RXRA protein Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein] |
CTD |
PMID:11504768 |
|
NCBI chr 3:31,387,892...31,474,415
|
|
G |
S100a11 |
S100 calcium binding protein A11 |
decreases expression |
ISO |
salvin results in decreased expression of S100A11 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:179,191,688...179,197,098
|
|
G |
S100a8 |
S100 calcium binding protein A8 |
decreases expression |
ISO |
salvin results in decreased expression of S100A8 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:178,464,095...178,465,223
|
|
G |
S100a9 |
S100 calcium binding protein A9 |
decreases expression |
ISO |
salvin results in decreased expression of S100A9 protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:178,487,941...178,490,622
|
|
G |
S100g |
S100 calcium binding protein G |
increases expression |
ISO |
salvin results in increased expression of S100G protein |
CTD |
PMID:35926579 |
|
NCBI chr X:31,705,853...31,708,422
|
|
G |
Sdc3 |
syndecan 3 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of SDC3 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 5:142,965,659...142,998,390
|
|
G |
Serpina3n |
serpin family A member 3N |
decreases expression |
ISO |
salvin results in decreased expression of SERPINA3N protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:123,323,623...123,331,181
|
|
G |
Sgsm3 |
small G protein signaling modulator 3 |
decreases expression |
ISO |
salvin results in decreased expression of SGSM3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:112,514,453...112,544,109
|
|
G |
Shc1 |
SHC adaptor protein 1 |
multiple interactions increases expression decreases expression |
ISO |
salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] salvin results in increased expression of SHC1 mRNA |
CTD |
PMID:24557422 |
|
NCBI chr 2:177,135,649...177,147,257
|
|
G |
Shmt2 |
serine hydroxymethyltransferase 2 |
decreases expression |
ISO |
salvin results in decreased expression of SHMT2 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:63,358,961...63,364,293
|
|
G |
Sik2 |
salt-inducible kinase 2 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of SIK2 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 8:60,121,913...60,221,707
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions increases expression |
ISO |
Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] salvin results in increased expression of SIRT1 mRNA; salvin results in increased expression of SIRT1 protein |
CTD |
PMID:24557422 |
|
NCBI chr20:25,305,953...25,328,000
|
|
G |
Slc26a3 |
solute carrier family 26 member 3 |
increases expression |
ISO |
salvin results in increased expression of SLC26A3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:53,751,415...53,792,300
|
|
G |
Slc35a2 |
solute carrier family 35 member A2 |
increases expression |
ISO |
salvin results in increased expression of SLC35A2 protein |
CTD |
PMID:35926579 |
|
NCBI chr X:14,608,145...14,616,937
|
|
G |
Sltm |
SAFB-like, transcription modulator |
decreases expression |
ISO |
salvin results in decreased expression of SLTM protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:71,215,995...71,261,821
|
|
G |
Snw1 |
SNW domain containing 1 |
decreases expression |
ISO |
salvin results in decreased expression of SNW1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 6:112,826,374...112,850,459
|
|
G |
Snx4 |
sorting nexin 4 |
decreases expression |
ISO |
salvin results in decreased expression of SNX4 protein |
CTD |
PMID:35926579 |
|
NCBI chr11:80,965,965...81,023,234
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO EXP |
salvin inhibits the reaction [Acrylamide results in decreased expression of SOD1 mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein] |
CTD |
PMID:25446857 PMID:28159594 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein] |
CTD |
PMID:24557422 PMID:26577515 PMID:26686574 |
|
NCBI chr 1:50,043,323...50,050,168
|
|
G |
Sorbs1 |
sorbin and SH3 domain containing 1 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in decreased expression of SORBS1 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr 1:249,057,324...249,279,703
|
|
G |
Sparc |
secreted protein acidic and cysteine rich |
decreases expression |
ISO |
salvin results in decreased expression of SPARC protein |
CTD |
PMID:35926579 |
|
NCBI chr10:39,516,394...39,538,252
|
|
G |
Sprr2a |
small proline rich protein 2A |
decreases expression |
ISO |
salvin results in decreased expression of SPRR2A protein |
CTD |
PMID:35926579 |
|
NCBI chr 2:177,815,964...177,816,236
|
|
G |
Stub1 |
STIP1 homology and U-box containing protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of STUB1 protein |
CTD |
PMID:35926579 |
|
NCBI chr10:14,850,765...14,853,046
|
|
G |
Tbx3 |
T-box transcription factor 3 |
multiple interactions |
ISO |
salvin inhibits the reaction [sodium arsenite results in increased expression of TBX3 mRNA] |
CTD |
PMID:35202923 |
|
NCBI chr12:42,540,378...42,555,490
|
|
G |
Tep1 |
telomerase associated protein 1 |
decreases expression |
ISO |
salvin results in decreased expression of TEP1 protein |
CTD |
PMID:35926579 |
|
NCBI chr15:24,045,876...24,093,526
|
|
G |
Tf |
transferrin |
decreases expression |
ISO |
salvin results in decreased expression of TF protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:103,789,780...103,816,487
|
|
G |
Tgm3 |
transglutaminase 3 |
increases expression |
ISO |
salvin results in increased expression of TGM3 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:117,228,661...117,264,078
|
|
G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] |
CTD |
PMID:25446857 |
|
NCBI chr 1:207,500,959...207,508,276
|
|
G |
Tinagl1 |
tubulointerstitial nephritis antigen-like 1 |
increases expression |
ISO |
salvin results in increased expression of TINAGL1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:142,513,710...142,523,730
|
|
G |
Tmed5 |
transmembrane p24 trafficking protein 5 |
decreases expression |
ISO |
salvin results in decreased expression of TMED5 protein |
CTD |
PMID:35926579 |
|
NCBI chr14:1,607,895...1,619,028
|
|
G |
Tmsb4x |
thymosin beta 4, X-linked |
decreases expression |
ISO |
salvin results in decreased expression of TMSB4X protein |
CTD |
PMID:35926579 |
|
NCBI chr X:30,761,611...30,763,612
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
salvin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:21375325 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnxb |
tenascin XB |
increases expression |
ISO |
salvin results in increased expression of TNXB protein |
CTD |
PMID:35926579 |
|
|
|
G |
Tsg101 |
tumor susceptibility 101 |
decreases expression |
ISO |
salvin results in decreased expression of TSG101 protein |
CTD |
PMID:35926579 |
|
NCBI chr 1:106,549,035...106,578,859
|
|
G |
Tspan15 |
tetraspanin 15 |
increases expression |
ISO |
salvin results in increased expression of TSPAN15 protein |
CTD |
PMID:35926579 |
|
NCBI chr20:30,130,528...30,174,912
|
|
G |
Txlna |
taxilin alpha |
decreases expression |
ISO |
salvin results in decreased expression of TXLNA protein |
CTD |
PMID:35926579 |
|
NCBI chr 5:141,969,337...141,985,054
|
|
G |
Tyr |
tyrosinase |
decreases expression |
ISO |
salvin results in decreased expression of TYR mRNA |
CTD |
PMID:21071833 |
|
NCBI chr 1:150,527,687...150,622,857
|
|
G |
Ubl4a |
ubiquitin-like 4A |
decreases expression |
ISO |
salvin results in decreased expression of UBL4A protein |
CTD |
PMID:35926579 |
|
NCBI chr X:152,151,242...152,154,094
|
|
G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein] |
CTD |
PMID:30707903 |
|
NCBI chr10:37,029,377...37,060,542
|
|
G |
Vdr |
vitamin D receptor |
multiple interactions increases expression |
ISO |
Calcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein] |
CTD |
PMID:11504768 |
|
NCBI chr 7:130,864,764...130,916,757
|
|
G |
Vill |
villin-like |
decreases expression |
ISO |
salvin results in decreased expression of VILL protein |
CTD |
PMID:35926579 |
|
NCBI chr 8:118,776,718...118,794,983
|
|
G |
Wdr5 |
WD repeat domain 5 |
decreases expression |
ISO |
salvin results in decreased expression of WDR5 protein |
CTD |
PMID:35926579 |
|
NCBI chr 3:10,836,964...10,856,682
|
|
G |
Wif1 |
Wnt inhibitory factor 1 |
decreases expression |
ISO |
salvin results in decreased expression of WIF1 protein |
CTD |
PMID:35926579 |
|
NCBI chr 7:58,433,326...58,503,853
|
|
G |
Zfp207 |
zinc finger protein 207 |
decreases expression |
ISO |
salvin results in decreased expression of ZFP207 protein; salvin results in decreased expression of ZNF207 protein |
CTD |
PMID:35926579 |
|
NCBI chr10:65,883,630...65,895,895
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] |
CTD |
PMID:35101544 |
|
NCBI chr 3:74,424,620...74,520,646
|
|
G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
decreases expression |
ISO |
cryptotanshinone results in decreased expression of ACAT1 mRNA |
CTD |
PMID:38936533 |
|
NCBI chr 8:53,979,813...54,008,861
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
cryptotanshinone binds to and results in decreased activity of ACHE protein |
CTD |
PMID:20350537 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
ISO |
cryptotanshinone results in decreased expression of ACTA2 mRNA; cryptotanshinone results in decreased expression of ACTA2 protein CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein] cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:38936533 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
cryptotanshinone binds to and results in decreased activity of BCHE protein |
CTD |
PMID:20350537 |
|
NCBI chr 2:160,607,289...160,699,760
|
|
G |
Casp3 |
caspase 3 |
increases cleavage increases activity multiple interactions |
ISO |
cryptotanshinone results in increased cleavage of CASP3 protein cryptotanshinone results in increased activity of CASP3 protein benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein] |
CTD |
PMID:26564229 PMID:28600121 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp7 |
caspase 7 |
increases activity |
ISO |
cryptotanshinone results in increased activity of CASP7 protein |
CTD |
PMID:26564229 |
|
NCBI chr 1:265,442,647...265,481,938
|
|
G |
Casp9 |
caspase 9 |
increases activity |
ISO |
cryptotanshinone results in increased activity of CASP9 protein |
CTD |
PMID:26564229 |
|
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] |
CTD |
PMID:30208247 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO |
CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein] cryptotanshinone results in decreased expression of COL1A1 mRNA; cryptotanshinone results in decreased expression of COL1A1 protein cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:38936533 |
|
NCBI chr10:80,380,458...80,397,461
|
|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions decreases expression |
ISO |
CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein] cryptotanshinone results in decreased expression of CPT1A mRNA; cryptotanshinone results in decreased expression of CPT1A protein |
CTD |
PMID:38936533 |
|
NCBI chr 1:209,993,881...210,056,329
|
|
G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
ISO |
cryptotanshinone results in decreased expression of CPT1B mRNA |
CTD |
PMID:38936533 |
|
NCBI chr 7:120,491,354...120,500,833
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] |
CTD |
PMID:30208247 |
|
NCBI chr 8:129,517,576...129,544,661
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA] cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein |
CTD |
PMID:21262253 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
cryptotanshinone results in increased expression of CYP3A4 protein |
CTD |
PMID:18805405 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] |
CTD |
PMID:30208247 |
|
NCBI chr14:95,378,626...95,551,358
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; cryptotanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] |
CTD |
PMID:36804361 PMID:38936533 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] |
CTD |
PMID:30208247 |
|
NCBI chr11:76,004,502...76,154,665
|
|
G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
cryptotanshinone results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:38936533 |
|
NCBI chr 1:236,408,905...236,468,769
|
|
G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] |
CTD |
PMID:28600121 |
|
NCBI chr19:66,571,631...66,582,270
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [notoginsenoside R1 results in increased expression of MCL1 protein] |
CTD |
PMID:38316350 |
|
NCBI chr 2:185,884,840...185,912,532
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:28600121 |
|
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
cryptotanshinone results in increased activity of NR1I2 protein |
CTD |
PMID:18805405 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
cryptotanshinone results in increased cleavage of PARP1 protein |
CTD |
PMID:26564229 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Ptger2 |
prostaglandin E receptor 2 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] |
CTD |
PMID:30208247 |
|
NCBI chr15:18,215,013...18,228,714
|
|
G |
Ptger4 |
prostaglandin E receptor 4 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] |
CTD |
PMID:30208247 |
|
NCBI chr 2:56,061,699...56,074,594
|
|
G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
decreases activity |
ISO |
cryptotanshinone results in decreased activity of PTPN1 protein |
CTD |
PMID:29031618 |
|
NCBI chr 3:156,638,811...156,687,503
|
|
G |
Rarb |
retinoic acid receptor, beta |
increases expression |
ISO |
cryptotanshinone results in increased expression of RARB protein |
CTD |
PMID:38936533 |
|
NCBI chr15:10,837,252...11,482,037
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
ISO |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:26564229 PMID:28600121 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Rxra |
retinoid X receptor alpha |
increases expression |
ISO |
cryptotanshinone results in increased expression of RXRA protein |
CTD |
PMID:38936533 |
|
NCBI chr 3:31,387,892...31,474,415
|
|
G |
Sqstm1 |
sequestosome 1 |
multiple interactions decreases expression |
ISO |
Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28600121 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation multiple interactions |
ISO |
cryptotanshinone results in decreased phosphorylation of STAT3 protein cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein] cryptotanshinone results in decreased phosphorylation of and affects the localization of STAT3 protein |
CTD |
PMID:28578322 PMID:38936533 |
|
NCBI chr10:86,311,528...86,363,513
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:38936533 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] |
CTD |
PMID:26564229 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Top2a |
DNA topoisomerase II alpha |
decreases expression multiple interactions |
ISO |
cryptotanshinone results in decreased expression of TOP2A mRNA cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein |
CTD |
PMID:28716507 |
|
NCBI chr10:84,441,954...84,473,093
|
|
G |
Top2b |
DNA topoisomerase II beta |
decreases expression |
ISO |
cryptotanshinone results in decreased expression of TOP2B mRNA |
CTD |
PMID:28716507 |
|
NCBI chr15:11,482,089...11,542,464
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] |
CTD |
PMID:35101544 |
|
NCBI chr 3:74,424,620...74,520,646
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression |
ISO |
dihydrotanshinone I results in decreased expression of ACTA2 protein |
CTD |
PMID:38936533 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
dihydrotanshinone I binds to and results in increased activity of AHR protein; dihydrotanshinone I promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO |
dihydrotanshinone I results in increased phosphorylation of AKT1 protein |
CTD |
PMID:26282490 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in decreased expression of CASP8 protein] |
CTD |
PMID:29496522 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
dihydrotanshinone I results in decreased expression of COL1A1 protein |
CTD |
PMID:38936533 |
|
NCBI chr10:80,380,458...80,397,461
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
dihydrotanshinone I results in increased expression of CYP1A1 mRNA; dihydrotanshinone I results in increased expression of CYP1A1 protein Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
dihydrotanshinone I results in increased expression of CYP1A2 mRNA; dihydrotanshinone I results in increased expression of CYP1A2 protein Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
dihydrotanshinone I results in decreased activity of CYP2C8 protein |
CTD |
PMID:29689254 |
|
|
|
G |
Eif4e |
eukaryotic translation initiation factor 4E |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of EIF4E protein |
CTD |
PMID:26282490 |
|
NCBI chr 2:229,736,309...229,772,628
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:26282490 |
|
NCBI chr16:71,495,457...71,508,845
|
|
G |
Epo |
erythropoietin |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] |
CTD |
PMID:26282490 |
|
NCBI chr12:19,204,258...19,207,948
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] |
CTD |
PMID:36804361 |
|
NCBI chr 7:110,295,599...110,300,134
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression multiple interactions |
ISO |
dihydrotanshinone I results in decreased expression of HIF1A protein dihydrotanshinone I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dihydrotanshinone I inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; dihydrotanshinone I inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein] |
CTD |
PMID:26282490 |
|
NCBI chr 6:98,357,788...98,405,068
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein] |
CTD |
PMID:29496522 |
|
NCBI chr12:11,009,236...11,015,941
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein] |
CTD |
PMID:29496522 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein] |
CTD |
PMID:29496522 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:26282490 |
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:26282490 |
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of MLKL protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MLKL protein] |
CTD |
PMID:29496522 |
|
NCBI chr19:56,186,860...56,213,886
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein] |
CTD |
PMID:29496522 |
|
NCBI chr10:73,092,124...73,102,057
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of MTOR protein |
CTD |
PMID:26282490 |
|
NCBI chr 5:164,167,985...164,277,438
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:29496522 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:29496522 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK1 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK1 protein] |
CTD |
PMID:29496522 |
|
NCBI chr17:31,044,983...31,077,167
|
|
G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK3 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK3 protein] |
CTD |
PMID:29496522 |
|
NCBI chr15:33,253,071...33,262,025
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
dihydrotanshinone I results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:26282490 |
|
NCBI chr10:71,817,794...71,865,211
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein] |
CTD |
PMID:26282490 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein] |
CTD |
PMID:29496522 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] dihydrotanshinone I results in decreased expression of VEGFA protein |
CTD |
PMID:26282490 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein] |
CTD |
PMID:30086653 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] |
CTD |
PMID:32946155 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein] |
CTD |
PMID:32946155 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases expression |
ISO |
pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased expression of RELA protein]; SB 203580 inhibits the reaction [ferruginol results in increased expression of RELA protein] |
CTD |
PMID:30086653 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein] |
CTD |
PMID:32946155 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
EXP |
ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] |
CTD |
PMID:32946155 |
|
NCBI chr 1:78,342,571...78,346,255
|
|
G |
Tnnt2 |
troponin T2, cardiac type |
multiple interactions |
EXP |
ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] |
CTD |
PMID:32946155 |
|
NCBI chr13:49,819,123...49,837,125
|
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] |
CTD |
PMID:35810264 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
miltirone results in decreased activity of CYP2C19 protein |
CTD |
PMID:25686904 |
|
NCBI chr 1:247,879,058...247,916,804
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein]]; miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein] |
CTD |
PMID:35810264 |
|
NCBI chr11:42,942,742...42,948,399
|
|
|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
EXP ISO |
tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 protein] tanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] |
CTD |
PMID:35101544 PMID:35544702 |
|
NCBI chr 3:74,424,620...74,520,646
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein] |
CTD |
PMID:35243748 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein] |
CTD |
PMID:35243748 |
|
NCBI chr15:101,948,387...102,182,912
|
|
G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
increases expression |
ISO |
tanshinone results in increased expression of ACADVL mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:55,231,558...55,236,786
|
|
G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases expression |
ISO |
tanshinone results in increased expression of ACSL1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr16:45,755,246...45,821,541
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP ISO |
tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein] |
CTD |
PMID:32097614 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
tanshinone binds to and results in increased activity of AHR protein; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] |
CTD |
PMID:21262253 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein] tanshinone inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein] tanshinone results in increased phosphorylation of AKT1 protein |
CTD |
PMID:34655285 PMID:38348705 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
decreases expression |
ISO |
tanshinone results in decreased expression of ALDH1A3 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:119,982,272...120,017,416
|
|
G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
decreases expression |
ISO |
tanshinone results in decreased expression of ALDH3A2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:46,427,789...46,448,449
|
|
G |
Apoc1 |
apolipoprotein C1 |
increases expression |
ISO |
tanshinone results in increased expression of APOC1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:79,347,057...79,350,340
|
|
G |
Apom |
apolipoprotein M |
increases expression |
ISO |
tanshinone results in increased expression of APOM mRNA |
CTD |
PMID:15849732 |
|
NCBI chr20:3,690,950...3,693,550
|
|
G |
Aqp9 |
aquaporin 9 |
multiple interactions |
ISO |
[[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] |
CTD |
PMID:18344322 |
|
NCBI chr 8:80,678,027...80,718,273
|
|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
decreases expression |
ISO |
tanshinone results in decreased expression of ASNS mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 4:36,752,061...36,769,970
|
|
G |
Ass1 |
argininosuccinate synthase 1 |
decreases expression |
ISO |
tanshinone results in decreased expression of ASS1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 3:14,747,355...14,796,909
|
|
G |
Atp6v0b |
ATPase H+ transporting V0 subunit B |
increases expression |
ISO |
tanshinone results in increased expression of ATP6V0B mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 5:131,423,384...131,424,900
|
|
G |
Atp6v1e1 |
ATPase H+ transporting V1 subunit E1 |
increases expression |
ISO |
tanshinone results in increased expression of ATP6V1E1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 4:154,022,358...154,044,486
|
|
G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP |
tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein] |
CTD |
PMID:34655285 |
|
NCBI chr 1:213,562,719...213,572,034
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
tanshinone results in increased expression of BAX protein |
CTD |
PMID:21699893 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bckdhb |
branched chain keto acid dehydrogenase E1 subunit beta |
decreases expression |
ISO |
tanshinone results in decreased expression of BCKDHB mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 8:84,845,264...85,027,812
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
tanshinone results in decreased expression of BCL2 protein |
CTD |
PMID:16009009 PMID:19885617 PMID:20369472 PMID:21699893 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
tanshinone results in decreased expression of BIRC3 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 8:13,285,702...13,313,329
|
|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression multiple interactions |
ISO |
tanshinone results in decreased expression of BIRC5 mRNA SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA] |
CTD |
PMID:21165580 |
|
NCBI chr10:103,567,369...103,580,069
|
|
G |
Calcoco2 |
calcium binding and coiled-coil domain 2 |
increases expression |
ISO |
tanshinone results in increased expression of CALCOCO2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:81,055,467...81,069,298
|
|
G |
Casp3 |
caspase 3 |
increases expression multiple interactions increases activity |
ISO EXP |
tanshinone results in increased expression of CASP3 protein Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein] tanshinone results in increased activity of CASP3 protein |
CTD |
PMID:15849732 PMID:21699893 PMID:34655285 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] |
CTD |
PMID:26203587 |
|
NCBI chr 9:67,747,109...67,806,699
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Particulate Matter results in increased expression of CCND1 protein] |
CTD |
PMID:35304817 |
|
NCBI chr 1:209,518,288...209,527,986
|
|
G |
Cd33 |
CD33 molecule |
decreases expression |
ISO |
tanshinone results in decreased expression of CD33 protein |
CTD |
PMID:16009009 |
|
NCBI chr 1:103,071,985...103,086,687
|
|
G |
Cd36 |
CD36 molecule |
multiple interactions decreases expression |
ISO |
15-deoxyprostaglandin J2 inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]; tanshinone inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; tanshinone inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA] tanshinone results in decreased expression of CD36 mRNA; tanshinone results in decreased expression of CD36 protein |
CTD |
PMID:20854809 |
|
NCBI chr 4:18,209,088...18,302,142
|
|
G |
Cd68 |
Cd68 molecule |
decreases expression |
ISO |
tanshinone results in decreased expression of CD68 protein |
CTD |
PMID:20854809 |
|
NCBI chr10:54,880,562...54,882,441
|
|
G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
[Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein] |
CTD |
PMID:32097614 PMID:32886829 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
[tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] |
CTD |
PMID:18344322 |
|
NCBI chr 7:1,714,392...1,721,964
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
tanshinone results in increased expression of CDKN1A mRNA |
CTD |
PMID:15849732 |
|
NCBI chr20:7,150,820...7,161,373
|
|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] |
CTD |
PMID:18344322 |
|
NCBI chr 4:169,491,273...169,496,500
|
|
G |
Ceacam6 |
CEA cell adhesion molecule 6 |
decreases expression |
ISO |
tanshinone results in decreased expression of CEACAM6 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:80,416,531...80,434,668
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions increases expression |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] |
CTD |
PMID:18344322 |
|
NCBI chr 1:87,759,631...87,762,303
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression multiple interactions |
ISO |
tanshinone results in increased expression of CEBPB protein [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein] |
CTD |
PMID:18344322 |
|
NCBI chr 3:176,817,005...176,818,436
|
|
G |
Cebpe |
CCAAT/enhancer binding protein epsilon |
multiple interactions increases expression |
ISO |
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] |
CTD |
PMID:18344322 |
|
NCBI chr15:28,169,711...28,171,471
|
|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
tanshinone results in increased expression of CFLAR protein |
CTD |
PMID:26203587 |
|
NCBI chr 9:67,679,502...67,747,226
|
|
G |
Clu |
clusterin |
increases expression |
ISO |
tanshinone results in increased expression of CLU mRNA |
CTD |
PMID:15849732 |
|
NCBI chr15:40,161,068...40,200,315
|
|
G |
Col6a1 |
collagen type VI alpha 1 chain |
decreases expression |
ISO |
tanshinone results in decreased expression of COL6A1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr20:11,905,690...11,924,111
|
|
G |
Cst6 |
cystatin E/M |
increases expression |
ISO |
tanshinone results in increased expression of CST6 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:202,655,322...202,657,030
|
|
G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
ISO |
tanshinone results in increased expression of CTNNB1 mRNA [Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein] |
CTD |
PMID:25186638 PMID:32886829 |
|
NCBI chr 8:129,517,576...129,544,661
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein] |
CTD |
PMID:34655285 |
|
NCBI chr 4:80,982,667...80,984,767
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
tanshinone results in increased expression of CYP1A1 mRNA; tanshinone results in increased expression of CYP1A1 protein Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] |
CTD |
PMID:15849732 PMID:16955220 PMID:21262253 |
|
NCBI chr 8:66,991,940...66,998,014
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
tanshinone results in increased expression of CYP1A2 mRNA; tanshinone results in increased expression of CYP1A2 protein Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
CTD |
PMID:21262253 |
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NCBI chr 8:66,971,261...66,978,149
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
tanshinone results in decreased activity of CYP2C19 protein |
CTD |
PMID:25686904 |
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NCBI chr 1:247,879,058...247,916,804
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
tanshinone results in decreased activity of CYP2C8 protein |
CTD |
PMID:29689254 |
|
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases expression |
ISO |
NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
CTD |
PMID:18805405 |
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NCBI chr12:14,321,771...14,343,886
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G |
Dck |
deoxycytidine kinase |
increases expression |
ISO |
tanshinone results in increased expression of DCK mRNA |
CTD |
PMID:15849732 |
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NCBI chr14:19,589,298...19,610,326
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
[TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein] tanshinone results in increased expression of DDIT3 mRNA; tanshinone results in increased expression of DDIT3 protein |
CTD |
PMID:26203587 |
|
NCBI chr 7:65,001,695...65,006,517
|
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in decreased expression of DUSP1 protein] |
CTD |
PMID:29906494 |
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NCBI chr10:17,184,853...17,187,646
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G |
Dusp11 |
dual specificity phosphatase 11 |
increases expression |
ISO |
tanshinone results in increased expression of DUSP11 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 4:118,367,673...118,385,183
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
tanshinone results in increased expression of DUSP5 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 1:262,543,774...262,557,201
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G |
Dyrk4 |
dual specificity tyrosine phosphorylation regulated kinase 4 |
decreases expression |
ISO |
tanshinone results in decreased expression of DYRK4 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 4:161,401,580...161,443,816
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] |
CTD |
PMID:28985491 |
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NCBI chr17:22,660,799...22,666,687
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G |
Ednra |
endothelin receptor type A |
multiple interactions |
EXP |
tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] |
CTD |
PMID:28985491 |
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NCBI chr19:47,137,360...47,207,961
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G |
Ednrb |
endothelin receptor type B |
multiple interactions |
EXP |
tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of EDNRB protein] |
CTD |
PMID:28985491 |
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NCBI chr15:87,055,490...87,086,765
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G |
Elk1 |
ETS transcription factor ELK1 |
decreases response to substance decreases expression |
ISO |
ELK1 mRNA results in decreased susceptibility to tanshinone tanshinone results in decreased expression of ELK1 mRNA |
CTD |
PMID:30506648 |
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NCBI chr X:3,692,367...3,709,252
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G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
tanshinone results in increased expression of ENC1 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 2:28,550,670...28,562,591
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G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
decreases expression multiple interactions |
ISO |
tanshinone results in decreased expression of ERCC1 mRNA SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA] |
CTD |
PMID:21165580 |
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NCBI chr 1:78,971,310...79,007,963
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
tanshinone results in decreased expression of ETS2 mRNA |
CTD |
PMID:15849732 |
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NCBI chr11:48,491,057...48,507,843
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G |
F2rl1 |
F2R like trypsin receptor 1 |
increases expression |
ISO |
tanshinone results in increased expression of F2RL1 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 2:28,507,003...28,519,954
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G |
Flad1 |
flavin adenine dinucleotide synthetase 1 |
increases expression |
ISO |
tanshinone results in increased expression of FLAD1 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 2:174,819,451...174,828,921
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO EXP |
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] |
CTD |
PMID:32097614 |
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NCBI chr 9:80,645,507...80,714,200
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
ISO |
tanshinone results in increased expression of FOS protein tanshinone results in decreased expression of FOS mRNA |
CTD |
PMID:16009009 PMID:36819991 |
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NCBI chr 6:110,852,188...110,855,054
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G |
Gba1 |
glucosylceramidase beta 1 |
increases expression |
ISO |
tanshinone results in increased expression of GBA1 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 2:176,902,141...176,916,015
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G |
Gfap |
glial fibrillary acidic protein |
increases expression |
ISO |
tanshinone results in increased expression of GFAP mRNA; tanshinone results in increased expression of GFAP protein |
CTD |
PMID:16955220 |
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NCBI chr10:88,352,987...88,361,661
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] |
CTD |
PMID:38348705 |
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NCBI chr20:13,074,695...13,104,095
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G |
Gnaq |
G protein subunit alpha q |
multiple interactions |
EXP |
[tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein] |
CTD |
PMID:34655285 |
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NCBI chr 1:222,852,453...223,098,754
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; tanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] |
CTD |
PMID:36804361 PMID:38348705 |
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NCBI chr 7:110,295,599...110,300,134
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G |
Grb7 |
growth factor receptor bound protein 7 |
increases expression |
ISO |
tanshinone results in increased expression of GRB7 mRNA |
CTD |
PMID:15849732 |
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NCBI chr10:83,443,387...83,453,057
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
ISO |
tanshinone results in decreased expression of GSK3B mRNA |
CTD |
PMID:25186638 |
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NCBI chr11:76,004,502...76,154,665
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases expression |
ISO |
tanshinone results in decreased expression of GSTP1 mRNA |
CTD |
PMID:21165580 |
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NCBI chr 1:210,767,237...210,770,242
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G |
H1f2 |
H1.2 linker histone, cluster member |
multiple interactions |
ISO |
[tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] |
CTD |
PMID:18344322 |
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NCBI chr17:41,818,962...41,820,453
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] |
CTD |
PMID:18344322 |
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NCBI chr 5:147,138,328...147,165,387
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G |
Hdac3 |
histone deacetylase 3 |
increases expression |
ISO |
tanshinone results in increased expression of HDAC3 mRNA |
CTD |
PMID:15849732 |
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NCBI chr18:29,770,637...29,789,850
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP ISO |
tanshinone results in increased expression of HMOX1 protein tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] tanshinone promotes the reaction [Silicon Dioxide results in increased expression of HMOX1 protein] |
CTD |
PMID:19356721 PMID:32097614 PMID:38348705 |
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NCBI chr19:13,452,365...13,479,823
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
tanshinone results in increased expression of ID2 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 6:47,469,162...47,470,995
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G |
Igf2 |
insulin-like growth factor 2 |
multiple interactions |
EXP |
[Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; [IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein; [tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] |
CTD |
PMID:34655285 |
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NCBI chr 1:197,814,409...197,831,802
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G |
Igf2r |
insulin-like growth factor 2 receptor |
multiple interactions decreases expression |
EXP |
[IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein tanshinone results in decreased expression of IGF2R protein |
CTD |
PMID:34655285 |
|
NCBI chr 1:50,526,878...50,615,265
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] |
CTD |
PMID:30098273 |
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NCBI chr 3:137,030,200...137,036,581
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; tanshinone inhibits the reaction [Particulate Matter results in increased expression of IL6 protein] tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:29906494 PMID:35304817 |
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NCBI chr 4:5,889,999...5,894,575
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G |
Impdh2 |
inosine monophosphate dehydrogenase 2 |
decreases activity |
ISO |
tanshinone results in decreased activity of IMPDH2 protein |
CTD |
PMID:37871880 |
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NCBI chr 8:109,256,705...109,261,365
|
|
G |
Inppl1 |
inositol polyphosphate phosphatase-like 1 |
increases expression |
ISO |
tanshinone results in increased expression of INPPL1 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 1:156,183,043...156,197,500
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G |
Isg20 |
interferon stimulated exonuclease gene 20 |
increases expression |
ISO |
tanshinone results in increased expression of ISG20 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 1:142,234,729...142,246,403
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G |
Itga6 |
integrin subunit alpha 6 |
decreases expression |
ISO |
tanshinone results in decreased expression of ITGA6 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 3:56,604,512...56,689,428
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G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
tanshinone results in increased expression of ITGAM protein |
CTD |
PMID:16009009 |
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NCBI chr 1:192,089,496...192,139,947
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] |
CTD |
PMID:32097614 |
|
NCBI chr 8:19,768,375...19,777,862
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G |
Kras |
KRAS proto-oncogene, GTPase |
decreases response to substance multiple interactions decreases expression |
ISO |
KRAS mRNA results in decreased susceptibility to tanshinone tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of KRAS protein] tanshinone results in decreased expression of KRAS mRNA; tanshinone results in decreased expression of KRAS protein |
CTD |
PMID:30506648 PMID:38348705 |
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NCBI chr 4:179,916,255...179,949,613
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G |
Lrp1 |
LDL receptor related protein 1 |
decreases expression multiple interactions |
ISO |
tanshinone results in decreased expression of LRP1 mRNA SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA] |
CTD |
PMID:21165580 |
|
NCBI chr 7:65,265,639...65,346,196
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G |
Lrp5 |
LDL receptor related protein 5 |
decreases expression |
ISO |
tanshinone results in decreased expression of LRP5 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 1:200,814,247...200,917,581
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G |
Lrp8 |
LDL receptor related protein 8 |
decreases expression |
ISO |
tanshinone results in decreased expression of LRP8 mRNA |
CTD |
PMID:15849732 |
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NCBI chr 5:127,792,236...127,864,207
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G |
Maob |
monoamine oxidase B |
increases expression |
ISO |
tanshinone results in increased expression of MAOB mRNA |
CTD |
PMID:15849732 |
|
NCBI chr X:8,490,405...8,594,065
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G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
decreases expression |
ISO |
tanshinone results in decreased expression of MAP3K1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 2:45,081,889...45,150,555
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:29906494 |
|
NCBI chr16:8,645,171...8,728,225
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:29906494 |
|
NCBI chr10:34,670,750...34,711,972
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G |
Mipep |
mitochondrial intermediate peptidase |
decreases expression |
ISO |
tanshinone results in decreased expression of MIPEP mRNA |
CTD |
PMID:15849732 |
|
NCBI chr15:34,926,198...35,051,722
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G |
Mir21 |
microRNA 21 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Particulate Matter results in increased expression of MIR21 protein] |
CTD |
PMID:35304817 |
|
NCBI chr10:71,902,600...71,902,691
|
|
G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] |
CTD |
PMID:30098273 |
|
NCBI chr 8:12,943,453...12,963,966
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein] |
CTD |
PMID:32886829 |
|
NCBI chr19:30,327,643...30,355,856
|
|
G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
tanshinone results in decreased expression of MMP7 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 8:13,133,043...13,140,761
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
[Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein] |
CTD |
PMID:24929186 PMID:32886829 |
|
NCBI chr 3:174,103,474...174,111,434
|
|
G |
Msr1 |
macrophage scavenger receptor 1 |
decreases expression |
ISO |
tanshinone results in decreased expression of MSR1 mRNA |
CTD |
PMID:20854809 |
|
NCBI chr16:52,717,775...52,803,602
|
|
G |
Mybl2 |
MYB proto-oncogene like 2 |
increases expression |
ISO |
tanshinone results in increased expression of MYBL2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 3:172,124,765...172,153,221
|
|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression multiple interactions |
ISO |
tanshinone results in decreased expression of MYC protein [Doxorubicin co-treated with tanshinone] affects the expression of MYC protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MYC protein] [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein] tanshinone results in decreased expression of MYC mRNA; tanshinone results in decreased expression of MYC protein |
CTD |
PMID:16009009 PMID:18344322 PMID:21699893 PMID:32886829 |
|
NCBI chr 7:95,483,105...95,488,031
|
|
G |
Myl1 |
myosin, light chain 1 |
increases expression |
ISO |
tanshinone results in increased expression of MYL1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 9:68,437,514...68,458,256
|
|
G |
Naa10 |
N(alpha)-acetyltransferase 10, NatA catalytic subunit |
increases expression |
ISO |
tanshinone results in increased expression of NAA10 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr X:156,807,378...156,812,632
|
|
G |
Nanog |
Nanog homeobox |
multiple interactions increases expression |
EXP ISO |
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of NANOG protein] tanshinone results in increased expression of NANOG mRNA |
CTD |
PMID:25186638 PMID:31108107 |
|
NCBI chr 4:155,943,737...155,951,116
|
|
G |
Ndufb2 |
NADH:ubiquinone oxidoreductase subunit B2 |
increases expression |
ISO |
tanshinone results in increased expression of NDUFB2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 4:69,334,307...69,341,394
|
|
G |
Ndufv1 |
NADH:ubiquinone oxidoreductase core subunit V1 |
increases expression |
ISO |
tanshinone results in increased expression of NDUFV1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:201,300,365...201,305,461
|
|
G |
Nes |
nestin |
decreases expression |
ISO |
tanshinone results in decreased expression of NES mRNA; tanshinone results in decreased expression of NES protein |
CTD |
PMID:16955220 |
|
NCBI chr 2:175,735,715...175,745,631
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO EXP |
[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein] [tanshinone co-treated with Rifampin] results in increased expression of NFE2L2 mRNA; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 protein] [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein]; tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]; tanshinone promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:32097614 PMID:33307820 PMID:35243748 PMID:38348705 |
|
NCBI chr 3:81,001,529...81,031,165
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein] tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:29906494 PMID:30268796 |
|
NCBI chr 6:78,593,844...78,597,307
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] |
CTD |
PMID:23500011 PMID:24239652 PMID:29906494 |
|
NCBI chr10:64,313,335...64,349,221
|
|
G |
Nos3 |
nitric oxide synthase 3 |
increases expression multiple interactions |
ISO EXP |
tanshinone results in increased expression of NOS3 mRNA; tanshinone results in increased expression of NOS3 protein HC-067047 inhibits the reaction [tanshinone results in increased expression of NOS3 protein] tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein] |
CTD |
PMID:15849732 PMID:28985491 PMID:39089414 |
|
NCBI chr 4:11,686,088...11,706,604
|
|
G |
Nppb |
natriuretic peptide B |
decreases expression |
ISO |
tanshinone results in decreased expression of NPPB protein |
CTD |
PMID:37643320 |
|
NCBI chr 5:163,699,955...163,701,314
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NQO1 protein] |
CTD |
PMID:32097614 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions |
ISO |
tanshinone results in increased activity of NR1I2 protein NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein] |
CTD |
PMID:18805405 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
CTD |
PMID:18805405 |
|
NCBI chr13:86,165,327...86,170,362
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
CTD |
PMID:18805405 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
decreases expression |
ISO |
tanshinone results in decreased expression of OLR1 mRNA; tanshinone results in decreased expression of OLR1 protein |
CTD |
PMID:22677363 |
|
NCBI chr 4:164,612,460...164,635,082
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] |
CTD |
PMID:26203587 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Parp4 |
poly (ADP-ribose) polymerase family, member 4 |
increases expression |
ISO |
tanshinone results in increased expression of PARP4 mRNA |
CTD |
PMID:15849732 PMID:16955220 |
|
NCBI chr15:34,806,203...34,908,492
|
|
G |
Pcsk7 |
proprotein convertase subtilisin/kexin type 7 |
increases expression |
ISO |
tanshinone results in increased expression of PCSK7 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 8:55,098,821...55,121,416
|
|
G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression multiple interactions |
EXP |
tanshinone results in increased expression of PHGDH mRNA tanshinone inhibits the reaction [Estrogens deficiency results in increased methylation of PHGDH promoter] |
CTD |
PMID:31108107 |
|
NCBI chr 2:185,906,962...185,936,054
|
|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein] |
CTD |
PMID:34655285 |
|
NCBI chr 2:34,612,946...34,697,660
|
|
G |
Plod2 |
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
decreases expression |
ISO |
tanshinone results in decreased expression of PLOD2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 8:93,084,548...93,167,255
|
|
G |
Pou5f1 |
POU class 5 homeobox 1 |
increases expression multiple interactions |
ISO EXP |
tanshinone results in increased expression of POU5F1 mRNA tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of POU5F1 protein] |
CTD |
PMID:25186638 PMID:31108107 |
|
NCBI chr20:3,227,836...3,232,598
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
tanshinone results in decreased expression of PPARG mRNA |
CTD |
PMID:20854809 |
|
NCBI chr 4:150,095,743...150,221,104
|
|
G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions |
EXP |
[Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] |
CTD |
PMID:34655285 |
|
NCBI chr 2:227,839,058...228,113,560
|
|
G |
Pram1 |
PML-RARA regulated adaptor molecule 1 |
multiple interactions |
ISO |
[tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein |
CTD |
PMID:18344322 |
|
NCBI chr 7:14,428,548...14,438,081
|
|
G |
Prkg1 |
protein kinase cGMP-dependent 1 |
increases expression multiple interactions |
EXP |
tanshinone results in increased expression of PRKG1 protein [HC-067047 co-treated with tanshinone] results in decreased expression of PRKG1 protein |
CTD |
PMID:39089414 |
|
NCBI chr 1:237,818,950...239,052,184
|
|
G |
Prpf6 |
pre-mRNA processing factor 6 |
decreases expression |
ISO |
tanshinone results in decreased expression of PRPF6 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 3:189,084,465...189,148,705
|
|
G |
Psmb5 |
proteasome 20S subunit beta 5 |
increases expression |
ISO |
tanshinone results in increased expression of PSMB5 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr15:32,042,784...32,047,379
|
|
G |
Psmd2 |
proteasome 26S subunit ubiquitin receptor, non-ATPase 2 |
increases expression |
ISO |
tanshinone results in increased expression of PSMD2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr11:80,248,364...80,258,991
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein] tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:22288910 PMID:23500011 PMID:24239652 PMID:24967690 |
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Ptprk |
protein tyrosine phosphatase, receptor type, K |
decreases expression |
ISO |
tanshinone results in decreased expression of PTPRK mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:18,557,091...19,056,297
|
|
G |
Ptx3 |
pentraxin 3 |
decreases secretion decreases expression multiple interactions |
ISO |
tanshinone results in decreased secretion of PTX3 protein tanshinone results in decreased expression of PTX3 mRNA tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] |
CTD |
PMID:30268796 |
|
NCBI chr 2:152,797,563...152,803,372
|
|
G |
Rarb |
retinoic acid receptor, beta |
increases expression multiple interactions |
ISO |
tanshinone results in increased expression of RARB mRNA [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] |
CTD |
PMID:18344322 |
|
NCBI chr15:10,837,252...11,482,037
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions increases expression |
ISO |
[indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein; [tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein tanshinone results in increased expression of RB1 protein |
CTD |
PMID:18344322 |
|
NCBI chr15:54,780,858...54,911,989
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein] |
CTD |
PMID:30268796 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Rhoc |
ras homolog family member C |
increases expression |
ISO |
tanshinone results in increased expression of RHOC mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 2:192,287,065...192,293,292
|
|
G |
Sephs2 |
selenophosphate synthetase 2 |
increases expression |
ISO |
tanshinone results in increased expression of SEPHS2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 1:191,323,637...191,325,955
|
|
G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
EXP |
[tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 mRNA; [tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 protein; tanshinone inhibits the reaction [Rifampin results in decreased expression of SLC10A1 protein] |
CTD |
PMID:33307820 |
|
NCBI chr 6:100,613,045...100,626,670
|
|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:32097614 |
|
NCBI chr 8:64,126,829...64,236,960
|
|
G |
Smad7 |
SMAD family member 7 |
multiple interactions |
ISO |
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein] |
CTD |
PMID:32097614 |
|
NCBI chr18:71,263,508...71,291,849
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
increases expression multiple interactions |
ISO EXP |
tanshinone results in increased expression of SOX2 mRNA tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of SOX2 protein] |
CTD |
PMID:25186638 PMID:31108107 |
|
NCBI chr 2:117,536,929...117,539,340
|
|
G |
Sp2 |
Sp2 transcription factor |
decreases expression |
ISO |
tanshinone results in decreased expression of SP2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:81,940,580...81,970,040
|
|
G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
EXP |
tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] |
CTD |
PMID:19356721 |
|
NCBI chr14:5,613,569...5,620,695
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
tanshinone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:35304817 |
|
NCBI chr10:86,311,528...86,363,513
|
|
G |
Tesk1 |
testis associated actin remodelling kinase 1 |
increases expression |
ISO |
tanshinone results in increased expression of TESK1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 5:62,487,763...62,493,492
|
|
G |
Tfap4 |
transcription factor AP-4 |
decreases expression |
ISO |
tanshinone results in decreased expression of TFAP4 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:11,001,338...11,019,386
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases expression |
ISO |
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein] tanshinone results in increased expression of TGFB1 protein |
CTD |
PMID:32097614 PMID:37643320 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Tk1 |
thymidine kinase 1 |
increases expression |
ISO |
tanshinone results in increased expression of TK1 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr10:103,533,449...103,544,818
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]; tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] |
CTD |
PMID:29906494 PMID:30268796 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions increases response to substance |
ISO |
[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] tanshinone results in increased susceptibility to TNFSF10 protein |
CTD |
PMID:26203587 |
|
NCBI chr 2:112,136,550...112,155,903
|
|
G |
Tp53 |
tumor protein p53 |
increases expression decreases expression |
ISO |
tanshinone results in increased expression of TP53 protein tanshinone results in decreased expression of TRP53 mRNA tanshinone results in decreased expression of TP53 protein |
CTD |
PMID:16009009 PMID:19885617 PMID:20369472 PMID:36819991 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Trpv4 |
transient receptor potential cation channel, subfamily V, member 4 |
multiple interactions increases expression |
ISO EXP |
HC-067047 inhibits the reaction [tanshinone results in increased expression of and results in increased activity of TRPV4 protein]; tanshinone inhibits the reaction [Cycloheximide results in increased degradation of TRPV4 protein]; tanshinone results in increased expression of and results in increased activity of TRPV4 protein tanshinone results in increased expression of TRPV4 mRNA tanshinone results in increased expression of TRPV4 mRNA; tanshinone results in increased expression of TRPV4 protein |
CTD |
PMID:39089414 |
|
NCBI chr12:47,599,161...47,638,143
|
|
G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
tanshinone results in increased expression of VEGFA mRNA; tanshinone results in increased expression of VEGFA protein |
CTD |
PMID:25186638 PMID:37643320 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] |
CTD |
PMID:32097614 |
|
NCBI chr17:81,577,261...81,585,746
|
|
G |
Wfdc2 |
WAP four-disulfide core domain 2 |
increases expression |
ISO |
tanshinone results in increased expression of WFDC2 mRNA |
CTD |
PMID:15849732 |
|
NCBI chr 3:153,286,946...153,314,832
|
|