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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:abietane diterpenoid
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Accession:CHEBI:36762 term browser browse the term
Definition:A diterpenoid based on an abietane skeleton.
Synonyms:related_synonym: abietane diterpenoids



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abietic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO abietic acid results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:105,274,103...105,331,653 JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO abietic acid results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:243,790,296...243,819,042 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO abietic acid results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:213,032,135...213,052,192 JBrowse link
carnosic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO salvin results in decreased expression of A2M protein CTD PMID:35926579 NCBI chr 4:154,897,770...154,947,787 JBrowse link
G Aacs acetoacetyl-CoA synthetase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of AACS mRNA] CTD PMID:35202923 NCBI chr12:31,113,098...31,156,411 JBrowse link
G Abat 4-aminobutyrate aminotransferase increases expression ISO salvin results in increased expression of ABAT protein CTD PMID:35926579 NCBI chr10:7,503,351...7,599,474 JBrowse link
G Abca6 ATP binding cassette subfamily A member 6 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of ABCA6 mRNA] CTD PMID:35202923 NCBI chr10:95,142,805...95,212,087 JBrowse link
G Abhd11 abhydrolase domain containing 11 increases expression ISO salvin results in increased expression of ABHD11 protein CTD PMID:35926579 NCBI chr12:27,318,739...27,322,016 JBrowse link
G Abi1 abl-interactor 1 increases expression ISO salvin results in increased expression of ABI1 protein CTD PMID:35926579 NCBI chr17:85,098,837...85,179,829 JBrowse link
G Acly ATP citrate lyase increases expression ISO salvin results in increased expression of ACLY protein CTD PMID:35926579 NCBI chr10:85,412,045...85,464,253 JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO salvin results in increased expression of ACSS2 protein CTD PMID:35926579 NCBI chr 3:144,003,808...144,047,452 JBrowse link
G Actn1 actinin, alpha 1 increases expression ISO salvin results in increased expression of ACTN1 protein CTD PMID:35926579 NCBI chr 6:104,731,485...104,826,312 JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of ADCY9 mRNA] CTD PMID:35202923 NCBI chr10:11,645,373...11,768,462 JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE1 mRNA] CTD PMID:35202923 NCBI chr 9:2,329,398...2,484,959 JBrowse link
G Adgre4 adhesion G protein-coupled receptor E4 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of ADGRE4 mRNA] CTD PMID:35202923 NCBI chr 9:9,758,106...9,901,908 JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression ISO salvin results in increased expression of ADH1 protein CTD PMID:35926579 NCBI chr 2:226,797,303...226,808,892 JBrowse link
G Aebp1 AE binding protein 1 decreases expression ISO salvin results in decreased expression of AEBP1 protein CTD PMID:35926579 NCBI chr14:80,738,800...80,748,878 JBrowse link
G Agps alkylglycerone phosphate synthase decreases expression ISO salvin results in decreased expression of AGPS protein CTD PMID:35926579 NCBI chr 3:60,747,323...60,845,831 JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression ISO salvin results in decreased expression of AHSG protein CTD PMID:35926579 NCBI chr11:78,121,388...78,127,998 JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO salvin results in increased phosphorylation of AKT1 protein
salvin results in decreased phosphorylation of AKT1 protein
CTD PMID:25178877 PMID:25271104 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Alb albumin decreases expression ISO salvin results in decreased expression of ALB protein CTD PMID:35926579 NCBI chr14:17,891,564...17,907,043 JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO salvin results in decreased expression of ALDH1A3 protein CTD PMID:35926579 NCBI chr 1:119,982,272...120,017,416 JBrowse link
G Amy2a1 amylase 2a1 decreases expression ISO salvin results in decreased expression of AMY2A1 protein CTD PMID:35926579 NCBI chr 2:201,344,912...201,353,500 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:29854073 NCBI chr 7:27,381,392...27,466,772 JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO salvin results in decreased expression of APOA1 protein CTD PMID:35926579 NCBI chr 8:55,423,945...55,425,729 JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO salvin results in decreased expression of APOA4 protein CTD PMID:35926579 NCBI chr 8:55,435,779...55,438,160 JBrowse link
G Apoe apolipoprotein E decreases expression ISO salvin results in decreased expression of APOE protein CTD PMID:35926579 NCBI chr 1:88,481,889...88,485,816 JBrowse link
G Apoh apolipoprotein H decreases expression ISO salvin results in decreased expression of APOH protein CTD PMID:35926579 NCBI chr10:93,342,435...93,356,334 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO salvin results in decreased expression of ASNS protein CTD PMID:35926579 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Aspa aspartoacylase decreases expression ISO salvin results in decreased expression of ASPA protein CTD PMID:35926579 NCBI chr10:57,891,704...57,945,267 JBrowse link
G Aspn asporin increases expression ISO salvin results in increased expression of ASPN protein CTD PMID:35926579 NCBI chr17:15,079,910...15,104,369 JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit increases expression ISO salvin results in increased expression of ATP12A protein CTD PMID:35926579 NCBI chr15:30,443,571...30,468,229 JBrowse link
G B2m beta-2 microglobulin increases expression ISO salvin results in increased expression of B2M protein CTD PMID:35926579 NCBI chr 3:129,549,236...129,555,354 JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
decreases phosphorylation
ISO salvin promotes the reaction [arsenic trioxide results in decreased phosphorylation of BAD protein]
salvin results in increased expression of BAD protein
salvin results in decreased phosphorylation of BAD protein
CTD PMID:23239002 PMID:28918123 NCBI chr 1:213,562,719...213,572,034 JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO salvin results in decreased expression of BASP1 protein CTD PMID:35926579 NCBI chr 2:77,546,628...77,594,297 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]
salvin results in increased expression of BAX protein
salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
CTD PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor decreases expression ISO salvin results in decreased expression of BCAS2 protein CTD PMID:35926579 NCBI chr 2:190,692,503...190,700,386 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
salvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 More... NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bcl2l2 Bcl2-like 2 multiple interactions ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein] CTD PMID:24557422 NCBI chr15:28,346,449...28,361,627 JBrowse link
G Bmp5 bone morphogenetic protein 5 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of BMP5 mRNA] CTD PMID:35202923 NCBI chr 8:76,517,164...76,639,925 JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 decreases expression ISO salvin results in decreased expression of BZW2 protein CTD PMID:35926579 NCBI chr 6:52,828,069...52,888,599 JBrowse link
G C3 complement C3 decreases expression ISO salvin results in decreased expression of C3 protein CTD PMID:35926579 NCBI chr 9:2,174,412...2,201,339 JBrowse link
G C4b complement C4B decreases expression ISO salvin results in decreased expression of C4B protein CTD PMID:35926579 NCBI chr20:4,197,371...4,211,684 JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO salvin results in decreased expression of CAMP protein CTD PMID:35926579 NCBI chr 8:109,841,729...109,843,543 JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO salvin results in increased expression of CA2 protein CTD PMID:35926579 NCBI chr 2:88,462,883...88,478,012 JBrowse link
G Casp14 caspase 14 increases expression ISO salvin results in increased expression of CASP14 protein CTD PMID:35926579 NCBI chr 7:10,929,759...10,932,591 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]
CTD PMID:24557422 PMID:25271104 PMID:25446857 PMID:26577515 PMID:26686574 More... NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp6 caspase 6 decreases expression ISO salvin results in decreased expression of CASP6 protein CTD PMID:35926579 NCBI chr 2:221,140,287...221,152,727 JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]
CTD PMID:28918123 PMID:29854073 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases cleavage
ISO salvin results in increased activity of CASP9 protein
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein]
salvin results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP9 mRNA]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]; salvin promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]
CTD PMID:23239002 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 More...
G Cat catalase multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA]
salvin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:28159594 PMID:29854073 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [salvin co-treated with Tretinoin] results in increased expression of CD14 protein; salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein] CTD PMID:11504768 NCBI chr18:28,609,558...28,611,409 JBrowse link
G Cd177 CD177 molecule decreases expression ISO salvin results in decreased expression of CD177 protein CTD PMID:35926579 NCBI chr 1:80,340,034...80,360,599 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO salvin results in increased expression of CDKN1B protein
salvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]
CTD PMID:23239002 NCBI chr 4:169,491,273...169,496,500 JBrowse link
G Cela1 chymotrypsin like elastase 1 decreases expression ISO salvin results in decreased expression of CELA1 protein CTD PMID:35926579 NCBI chr 7:131,773,161...131,786,300 JBrowse link
G Cela3b chymotrypsin like elastase 3B decreases expression ISO salvin results in decreased expression of CELA3B protein CTD PMID:35926579 NCBI chr 5:149,628,773...149,636,937 JBrowse link
G Chp2 calcineurin-like EF hand protein 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of CHP2 mRNA] CTD PMID:35202923 NCBI chr 1:186,189,090...186,203,663 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression ISO salvin results in increased expression of CKMT1 protein CTD PMID:35926579 NCBI chr 3:128,783,408...128,789,485 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO salvin results in increased expression of CLCA1 protein CTD PMID:35926579 NCBI chr 2:233,938,677...233,964,369 JBrowse link
G Clca4 chloride channel accessory 4 decreases expression ISO salvin results in decreased expression of CLCA4A protein CTD PMID:35926579 NCBI chr 2:233,883,625...233,904,993 JBrowse link
G Clec14a C-type lectin domain containing 14A multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of CLEC14A mRNA] CTD PMID:35202923 NCBI chr 6:75,881,470...75,884,612 JBrowse link
G Clic5 chloride intracellular channel 5 increases expression ISO salvin results in increased expression of CLIC5 protein CTD PMID:35926579 NCBI chr 9:16,710,980...16,813,502 JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A increases expression ISO salvin results in increased expression of CLNS1A protein CTD PMID:35926579 NCBI chr 1:152,019,369...152,039,670 JBrowse link
G Clu clusterin decreases expression ISO salvin results in decreased expression of CLU protein CTD PMID:35926579 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO salvin results in decreased expression of COL18A1 protein CTD PMID:35926579 NCBI chr20:11,474,104...11,582,593 JBrowse link
G Col6a3 collagen type VI alpha 3 chain decreases expression ISO salvin results in decreased expression of COL6A3 protein CTD PMID:35926579 NCBI chr 9:98,809,171...98,887,060 JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 increases expression ISO salvin results in increased expression of COX6A1 protein CTD PMID:35926579 NCBI chr12:41,261,983...41,265,037 JBrowse link
G Cp ceruloplasmin decreases expression ISO salvin results in decreased expression of CP protein CTD PMID:35926579 NCBI chr 2:104,368,336...104,427,119 JBrowse link
G Cpb1 carboxypeptidase B1 decreases expression ISO salvin results in decreased expression of CPB1 protein CTD PMID:35926579 NCBI chr 2:102,755,241...102,785,628 JBrowse link
G Cpox coproporphyrinogen oxidase increases expression ISO salvin results in increased expression of CPOX protein CTD PMID:35926579 NCBI chr11:41,936,585...41,946,568 JBrowse link
G Cpsf7 cleavage and polyadenylation specific factor 7 decreases expression ISO salvin results in decreased expression of CPSF7 protein CTD PMID:35926579 NCBI chr 1:216,592,745...216,616,860 JBrowse link
G Crnkl1 crooked neck pre-mRNA splicing factor 1 decreases expression ISO salvin results in decreased expression of CRNKL1 protein CTD PMID:35926579 NCBI chr 3:133,338,593...133,354,329 JBrowse link
G Ctrl chymotrypsin-like decreases expression ISO salvin results in decreased expression of CTRB1 protein CTD PMID:35926579 NCBI chr19:33,827,279...33,829,129 JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO salvin results in decreased expression of CYBB protein CTD PMID:35926579 NCBI chr  X:16,030,596...16,065,065 JBrowse link
G Cyp20a1 cytochrome P450, family 20, subfamily a, polypeptide 1 decreases expression ISO salvin results in decreased expression of CYP20A1 protein CTD PMID:35926579 NCBI chr 9:61,755,804...61,805,123 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP2B10 mRNA] CTD PMID:35202923 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases expression ISO salvin results in decreased expression of CYP2C66 protein CTD PMID:35926579 NCBI chr 1:246,490,888...246,582,199 JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO salvin results in decreased expression of CYP51A1 protein CTD PMID:35926579 NCBI chr 4:30,036,956...30,055,410 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of CYP7A1 mRNA] CTD PMID:35202923 NCBI chr 5:24,174,505...24,184,202 JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 decreases expression ISO salvin results in decreased expression of DMBT1 protein CTD PMID:35926579 NCBI chr 1:185,617,469...185,696,476 JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 decreases expression ISO salvin results in decreased expression of DNAJC10 protein CTD PMID:35926579 NCBI chr 3:65,232,031...65,272,732 JBrowse link
G Dop1b DOP1 leucine zipper like protein B multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of DOP1B mRNA] CTD PMID:35202923 NCBI chr11:33,024,376...33,125,931 JBrowse link
G Dpep1 dipeptidase 1 decreases expression ISO salvin results in decreased expression of DPEP1 protein CTD PMID:35926579 NCBI chr19:51,209,831...51,237,004 JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of EHHADH mRNA] CTD PMID:35202923 NCBI chr11:79,241,927...79,275,173 JBrowse link
G Elane elastase, neutrophil expressed decreases expression ISO salvin results in decreased expression of ELANE protein CTD PMID:35926579 NCBI chr 7:9,817,251...9,819,174 JBrowse link
G Eno3 enolase 3 increases expression ISO salvin results in increased expression of ENO3 protein CTD PMID:35926579 NCBI chr10:55,370,531...55,375,921 JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO salvin results in decreased expression of FABP1 protein CTD PMID:35926579 NCBI chr 4:104,744,302...104,753,119 JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO salvin results in decreased expression of FABP5 protein CTD PMID:35926579 NCBI chr 2:91,765,056...91,768,716 JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of FAS protein] CTD PMID:29854073 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fbln2 fibulin 2 decreases expression ISO salvin results in decreased expression of FBLN2 protein CTD PMID:35926579 NCBI chr 4:123,704,289...123,763,857 JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression ISO salvin results in decreased expression of FEN1 protein CTD PMID:35926579 NCBI chr 1:216,270,016...216,274,873 JBrowse link
G Fga fibrinogen alpha chain decreases expression ISO salvin results in decreased expression of FGA protein CTD PMID:35926579 NCBI chr 2:170,672,169...170,679,572 JBrowse link
G Fgb fibrinogen beta chain decreases expression ISO salvin results in decreased expression of FGB protein CTD PMID:35926579 NCBI chr 2:168,394,901...168,402,863 JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of FGF21 mRNA] CTD PMID:35202923 NCBI chr 1:105,219,825...105,221,376 JBrowse link
G Fgg fibrinogen gamma chain decreases expression ISO salvin results in decreased expression of FGG protein CTD PMID:35926579 NCBI chr 2:168,354,880...168,362,325 JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein] CTD PMID:31705926 NCBI chr12:25,345,239...25,360,135 JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO salvin results in increased expression of FMO2 protein CTD PMID:35926579 NCBI chr13:75,221,149...75,244,377 JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO salvin results in decreased expression of FSCN1 protein CTD PMID:35926579 NCBI chr12:16,710,601...16,723,734 JBrowse link
G Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 decreases expression ISO salvin results in decreased expression of GALNT12 protein CTD PMID:35926579 NCBI chr 5:61,384,575...61,413,346 JBrowse link
G Galnt3 polypeptide N-acetylgalactosaminyltransferase 3 decreases expression ISO salvin results in decreased expression of GALNT3 protein CTD PMID:35926579 NCBI chr 3:71,150,559...71,187,321 JBrowse link
G Garre1 granule associated Rac and RHOG effector 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of GARRE1 mRNA] CTD PMID:35202923 NCBI chr 1:86,862,121...86,939,725 JBrowse link
G Gc GC, vitamin D binding protein decreases expression ISO salvin results in decreased expression of GC protein CTD PMID:35926579 NCBI chr14:18,632,146...18,667,563 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
salvin results in increased expression of GCLC mRNA
salvin results in increased expression of GCLC protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]
CTD PMID:18329808 PMID:25446857 PMID:26577515 PMID:26686574 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
salvin results in increased expression of GCLM protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type decreases expression ISO salvin results in decreased expression of GCNT3 protein CTD PMID:35926579 NCBI chr 8:70,689,173...70,696,476 JBrowse link
G Gfer growth factor, augmenter of liver regeneration increases expression ISO salvin results in increased expression of GFER protein CTD PMID:35926579 NCBI chr10:13,718,489...13,721,782 JBrowse link
G Ggh gamma-glutamyl hydrolase increases expression ISO salvin results in increased expression of GGH protein CTD PMID:35926579 NCBI chr 5:33,529,880...33,552,790 JBrowse link
G Glod5 glyoxalase domain containing 5 increases expression ISO salvin results in increased expression of GLOD5 protein CTD PMID:35926579 NCBI chr  X:14,473,994...14,488,797 JBrowse link
G Gnl3 G protein nucleolar 3 decreases expression ISO salvin results in decreased expression of GNL3 protein CTD PMID:35926579 NCBI chr16:6,207,402...6,213,491 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of GPT protein] CTD PMID:29854073 PMID:35202923 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA] CTD PMID:28159594 NCBI chr 8:117,905,462...117,906,588 JBrowse link
G Grn granulin precursor decreases expression ISO salvin results in decreased expression of GRN protein CTD PMID:35926579 NCBI chr10:87,387,672...87,393,777 JBrowse link
G Gsdme gasdermin E multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of GSDME mRNA] CTD PMID:35202923 NCBI chr 4:79,258,799...79,321,129 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
salvin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
salvin results in increased expression of GSR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:29854073 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]
salvin results in increased expression of GSTP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]; salvin results in increased expression of and results in increased activity of GSTP1 protein
CTD PMID:25271104 PMID:26577515 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Gtf2f1 general transcription factor IIF subunit 1 decreases expression ISO salvin results in decreased expression of GTF2F1 protein CTD PMID:35926579 NCBI chr 9:1,931,033...1,940,197 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO salvin results in decreased expression of HMGCS2 protein CTD PMID:35926579 NCBI chr 2:185,875,609...185,903,505 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of HMOX1 mRNA; salvin results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]
CTD PMID:18329808 PMID:23942037 PMID:26686574 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 decreases expression ISO salvin results in decreased expression of HNRNPA3 protein CTD PMID:35926579 NCBI chr 3:60,578,574...60,588,755 JBrowse link
G Hp haptoglobin decreases expression ISO salvin results in decreased expression of HP protein CTD PMID:35926579 NCBI chr19:54,449,151...54,453,701 JBrowse link
G Hpx hemopexin decreases expression ISO salvin results in decreased expression of HPX protein CTD PMID:35926579 NCBI chr 1:159,932,819...159,940,327 JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression ISO salvin results in decreased expression of HSD17B6 protein CTD PMID:35926579 NCBI chr 7:422,466...442,008 JBrowse link
G Id3 inhibitor of DNA binding 3 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of ID3 mRNA] CTD PMID:35202923 NCBI chr 5:153,656,253...153,657,860 JBrowse link
G Ifng interferon gamma multiple interactions ISO salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO salvin results in decreased expression of IGFBP7 protein CTD PMID:35926579 NCBI chr14:30,737,414...30,797,317 JBrowse link
G Igkvl-ps13 immunoglobulin kappa variable like, pseudogene 13 decreases expression ISO salvin results in decreased expression of IGKV1-133 protein CTD PMID:35926579 NCBI chr 4:96,968,574...96,969,477 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions
increases ubiquitination
ISO PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein] CTD PMID:31705926 NCBI chr  X:157,358,279...157,397,563 JBrowse link
G Inhbe inhibin subunit beta E multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of INHBE mRNA] CTD PMID:35202923 NCBI chr 7:65,061,531...65,064,519 JBrowse link
G Inmt indolethylamine N-methyltransferase increases expression ISO salvin results in increased expression of INMT protein CTD PMID:35926579 NCBI chr 4:84,318,197...84,322,493 JBrowse link
G Ints3 integrator complex subunit 3 decreases expression ISO salvin results in decreased expression of INTS3 protein CTD PMID:35926579 NCBI chr 2:175,859,421...175,911,683 JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO salvin results in decreased expression of ITGA2 protein CTD PMID:35926579 NCBI chr 2:46,520,345...46,621,487 JBrowse link
G Itgam integrin subunit alpha M multiple interactions
decreases expression
ISO [salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; salvin promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; salvin promotes the reaction [Tretinoin results in increased expression of ITGAM protein]
salvin results in decreased expression of ITGAM protein
CTD PMID:11504768 PMID:35926579 NCBI chr 1:192,089,496...192,139,947 JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression ISO salvin results in decreased expression of ITGB2 protein CTD PMID:35926579 NCBI chr20:11,061,009...11,097,242 JBrowse link
G Klf12 KLF transcription factor 12 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of KLF12 mRNA] CTD PMID:35202923 NCBI chr15:83,037,548...83,469,998 JBrowse link
G Kng1 kininogen 1 decreases expression ISO salvin results in decreased expression of KNG1 protein CTD PMID:35926579 NCBI chr11:77,812,757...77,835,555 JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO salvin results in decreased expression of LAMP2 protein CTD PMID:35926579 NCBI chr  X:122,038,734...122,087,745 JBrowse link
G Lcn2 lipocalin 2 decreases expression ISO salvin results in decreased expression of LCN2 protein CTD PMID:35926579 NCBI chr 3:36,078,432...36,081,851 JBrowse link
G Lgals2 galectin 2 decreases expression ISO salvin results in decreased expression of LGALS2 protein CTD PMID:35926579 NCBI chr 7:112,283,630...112,290,228 JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression ISO salvin results in decreased expression of LGALS3BP protein CTD PMID:35926579 NCBI chr10:103,619,912...103,629,251 JBrowse link
G Lgals9 galectin 9 decreases expression ISO salvin results in decreased expression of LGALS9 protein CTD PMID:35926579 NCBI chr10:64,405,044...64,428,249 JBrowse link
G Lgmn legumain decreases expression ISO salvin results in decreased expression of LGMN protein CTD PMID:35926579 NCBI chr 6:121,544,048...121,582,495 JBrowse link
G Ltf lactotransferrin decreases expression ISO salvin results in decreased expression of LTF protein CTD PMID:35926579 NCBI chr 8:110,999,948...111,022,795 JBrowse link
G Luzp1 leucine zipper protein 1 decreases expression ISO salvin results in decreased expression of LUZP1 protein CTD PMID:35926579 NCBI chr 5:148,706,094...148,781,616 JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 increases expression ISO salvin results in increased expression of LYVE1 protein CTD PMID:35926579 NCBI chr 1:164,962,872...164,976,309 JBrowse link
G Lyz2 lysozyme 2 decreases expression ISO salvin results in decreased expression of LYZ2 protein CTD PMID:35926579 NCBI chr 7:52,906,810...52,912,154 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
CTD PMID:25446857 PMID:29854073 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein] CTD PMID:25446857 NCBI chr10:34,670,750...34,711,972 JBrowse link
G Marcksl1 MARCKS-like 1 decreases expression ISO salvin results in decreased expression of MARCKSL1 protein CTD PMID:35926579 NCBI chr 5:147,135,827...147,138,150 JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO salvin results in decreased expression of MCM7 protein CTD PMID:35926579 NCBI chr12:22,155,921...22,163,320 JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein] CTD PMID:31705926 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Mov10 Mov10 RNA helicase decreases expression ISO salvin results in decreased expression of MOV10 protein CTD PMID:35926579 NCBI chr 2:192,292,041...192,315,142 JBrowse link
G Mpo myeloperoxidase decreases expression ISO salvin results in decreased expression of MPO protein CTD PMID:35926579 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Mpzl2 myelin protein zero-like 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of MPZL2 mRNA] CTD PMID:35202923 NCBI chr 8:54,244,920...54,256,064 JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression ISO salvin results in decreased expression of MRPS31 protein CTD PMID:35926579 NCBI chr16:69,601,349...69,621,609 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO salvin results in decreased phosphorylation of MTOR protein CTD PMID:25178877 PMID:28918123 NCBI chr 5:164,167,985...164,277,438 JBrowse link
G Mug1 murinoglobulin 1 decreases expression ISO salvin results in decreased expression of MUG1 protein CTD PMID:35926579 NCBI chr 4:155,076,270...155,130,051 JBrowse link
G Mug2 murinoglobulin 2 decreases expression ISO salvin results in decreased expression of MUG2 protein CTD PMID:35926579 NCBI chr 4:155,164,061...155,236,894 JBrowse link
G Mylip myosin regulatory light chain interacting protein multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of MYLIP mRNA] CTD PMID:35202923 NCBI chr17:19,286,649...19,308,295 JBrowse link
G Myo1b myosin Ib decreases expression ISO salvin results in decreased expression of MYO1B protein CTD PMID:35926579 NCBI chr 9:49,690,043...49,852,373 JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of NDST1 mRNA] CTD PMID:35202923 NCBI chr18:54,136,887...54,199,545 JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 increases expression ISO salvin results in increased expression of NDUFA12 protein CTD PMID:35926579 NCBI chr 7:28,771,330...28,798,316 JBrowse link
G Nelfb negative elongation factor complex member B decreases expression ISO salvin results in decreased expression of NELFB protein CTD PMID:35926579 NCBI chr 3:28,409,045...28,425,564 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
ISO salvin results in increased activity of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin affects the localization of and results in increased activity of NFE2L2 protein; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 mRNA]; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]
CTD PMID:26577515 PMID:26686574 PMID:28159594 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; salvin results in increased phosphorylation of and results in increased degradation of NFKBIA protein
CTD PMID:21375325 PMID:25271104 PMID:29854073 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of NLRP12 mRNA] CTD PMID:35202923 NCBI chr 1:65,932,610...65,969,873 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21375325 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO salvin results in decreased expression of NOX1 protein CTD PMID:35926579 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of NQO1 mRNA
salvin results in increased expression of NQO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]
CTD PMID:18329808 PMID:26686574 PMID:28159594 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of NR3C2 mRNA] CTD PMID:35202923 NCBI chr19:47,619,853...47,964,089 JBrowse link
G Nrdc nardilysin convertase decreases expression ISO salvin results in decreased expression of NRDC protein CTD PMID:35926579 NCBI chr 5:123,755,807...123,818,910 JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression ISO salvin results in increased expression of OAS1G protein CTD PMID:35926579 NCBI chr12:35,669,798...35,680,505 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions
increases expression
ISO OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein] CTD PMID:31705926 NCBI chr11:84,612,943...84,690,025 JBrowse link
G Orm1 orosomucoid 1 decreases expression ISO salvin results in decreased expression of ORM1 protein CTD PMID:35926579 NCBI chr 5:81,788,509...81,791,661 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]
salvin results in decreased expression of PARP1 protein
CTD PMID:25446857 PMID:28918123 PMID:30707903 PMID:31705926 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 increases expression ISO salvin results in increased expression of PCBD2 protein CTD PMID:35926579 NCBI chr17:8,845,161...8,896,343 JBrowse link
G Pde5a phosphodiesterase 5A increases expression ISO salvin results in increased expression of PDE5A protein CTD PMID:35926579 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pdxk pyridoxal kinase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of PDXK mRNA] CTD PMID:35202923 NCBI chr20:10,209,975...10,232,012 JBrowse link
G Per2 period circadian regulator 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of PER2 mRNA] CTD PMID:35202923 NCBI chr 9:99,454,828...99,497,069 JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase decreases expression ISO salvin results in decreased expression of PGAM5 protein CTD PMID:35926579 NCBI chr12:52,069,023...52,076,131 JBrowse link
G Pglyrp1 peptidoglycan recognition protein 1 decreases expression ISO salvin results in decreased expression of PGLYRP1 protein CTD PMID:35926579 NCBI chr 1:78,531,815...78,537,001 JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO salvin results in decreased expression of PHGDH protein CTD PMID:35926579 NCBI chr 2:185,906,962...185,936,054 JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein] CTD PMID:30707903 NCBI chr 5:155,813,838...155,825,950 JBrowse link
G Plg plasminogen decreases expression ISO salvin results in decreased expression of PLG protein CTD PMID:35926579 NCBI chr 1:48,325,186...48,367,643 JBrowse link
G Plin2 perilipin 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of PLIN2 mRNA] CTD PMID:35202923 NCBI chr 5:106,202,634...106,258,748 JBrowse link
G Plin4 perilipin 4 increases expression ISO salvin results in increased expression of PLIN4 protein CTD PMID:35926579 NCBI chr 9:929,168...938,062 JBrowse link
G Plpp1 phospholipid phosphatase 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of PLPP1 mRNA] CTD PMID:35202923 NCBI chr 2:46,172,202...46,233,632 JBrowse link
G Pnlip pancreatic lipase decreases expression ISO salvin results in decreased expression of PNLIP protein CTD PMID:35926579 NCBI chr 1:257,774,012...257,811,656 JBrowse link
G Pnliprp1 pancreatic lipase-related protein 1 decreases expression ISO salvin results in decreased expression of PNLIPRP1 protein CTD PMID:35926579 NCBI chr 1:257,867,885...257,883,514 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO salvin results in increased activity of PPARG protein CTD PMID:20696231 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO salvin results in increased expression of PRDX6 protein CTD PMID:35926579 NCBI chr13:73,528,746...73,539,295 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases expression
ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]
salvin results in increased expression of PRKN protein
CTD PMID:30707903 PMID:31705926 NCBI chr 1:51,236,410...52,430,242 JBrowse link
G Prom1 prominin 1 decreases expression ISO salvin results in decreased expression of PROM1 protein CTD PMID:35926579 NCBI chr14:71,202,303...71,307,008 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA]
salvin results in increased expression of PTEN mRNA
CTD PMID:23239002 NCBI chr 1:240,043,707...240,110,330 JBrowse link
G Ptgds prostaglandin D2 synthase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of PTGDS mRNA] CTD PMID:35202923 NCBI chr 3:28,680,044...28,682,978 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21375325 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Pvalb parvalbumin decreases expression ISO salvin results in decreased expression of PVALB protein CTD PMID:35926579 NCBI chr 7:111,653,820...111,668,469 JBrowse link
G Pxdn peroxidasin decreases expression ISO salvin results in decreased expression of PXDN protein CTD PMID:35926579 NCBI chr 6:46,580,749...46,658,345 JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 decreases expression ISO salvin results in decreased expression of QSOX1 protein CTD PMID:35926579 NCBI chr13:67,949,780...67,987,434 JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of RAB11FIP2 mRNA] CTD PMID:35202923 NCBI chr 1:268,908,825...269,080,691 JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of RAPGEF5 mRNA] CTD PMID:35202923 NCBI chr 6:138,445,184...138,679,943 JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein CTD PMID:11504768 NCBI chr10:83,883,490...83,928,932 JBrowse link
G Rbpms RNA binding protein, mRNA processing factor multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of RBPMS mRNA] CTD PMID:35202923 NCBI chr16:58,239,370...58,395,424 JBrowse link
G Rdh9 retinol dehydrogenase 9 decreases expression ISO salvin results in decreased expression of RDH9 protein CTD PMID:35926579 NCBI chr 7:63,642,305...63,645,149 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects localization
ISO salvin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of RELA protein]
salvin results in increased expression of RELA protein
salvin affects the localization of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; salvin results in increased expression of and results in increased activity of RELA protein
CTD PMID:21375325 PMID:25271104 PMID:29854073 PMID:31705926 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rer1 retention in endoplasmic reticulum sorting receptor 1 increases expression ISO salvin results in increased expression of RER1 protein CTD PMID:35926579 NCBI chr 5:170,916,643...170,929,073 JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases expression ISO salvin results in decreased expression of RHEB protein CTD PMID:35926579 NCBI chr 4:11,012,173...11,053,860 JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression ISO salvin results in decreased expression of RNASE4 protein CTD PMID:35926579 NCBI chr15:26,786,287...26,803,634 JBrowse link
G Rpa1 replication protein A1 decreases expression ISO salvin results in decreased expression of RPA1 protein CTD PMID:35926579 NCBI chr10:60,647,185...60,698,279 JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 increases expression ISO salvin results in increased expression of RPS21 protein CTD PMID:35926579 NCBI chr 5:153,387,133...153,387,476 JBrowse link
G Rxra retinoid X receptor alpha increases expression
multiple interactions
ISO salvin results in increased expression of RXRA protein
Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]
CTD PMID:11504768 NCBI chr 3:31,387,892...31,474,415 JBrowse link
G S100a11 S100 calcium binding protein A11 decreases expression ISO salvin results in decreased expression of S100A11 protein CTD PMID:35926579 NCBI chr 2:179,191,688...179,197,098 JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression ISO salvin results in decreased expression of S100A8 protein CTD PMID:35926579 NCBI chr 2:178,464,095...178,465,223 JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO salvin results in decreased expression of S100A9 protein CTD PMID:35926579 NCBI chr 2:178,487,941...178,490,622 JBrowse link
G S100g S100 calcium binding protein G increases expression ISO salvin results in increased expression of S100G protein CTD PMID:35926579 NCBI chr  X:31,705,853...31,708,422 JBrowse link
G Sdc3 syndecan 3 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of SDC3 mRNA] CTD PMID:35202923 NCBI chr 5:142,965,659...142,998,390 JBrowse link
G Serpina3n serpin family A member 3N decreases expression ISO salvin results in decreased expression of SERPINA3N protein CTD PMID:35926579 NCBI chr 6:123,323,623...123,331,181 JBrowse link
G Sgsm3 small G protein signaling modulator 3 decreases expression ISO salvin results in decreased expression of SGSM3 protein CTD PMID:35926579 NCBI chr 7:112,514,453...112,544,109 JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
decreases expression
ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SHC1 mRNA
CTD PMID:24557422 NCBI chr 2:177,135,649...177,147,257 JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 decreases expression ISO salvin results in decreased expression of SHMT2 protein CTD PMID:35926579 NCBI chr 7:63,358,961...63,364,293 JBrowse link
G Sik2 salt-inducible kinase 2 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of SIK2 mRNA] CTD PMID:35202923 NCBI chr 8:60,121,913...60,221,707 JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SIRT1 mRNA; salvin results in increased expression of SIRT1 protein
CTD PMID:24557422 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Slc26a3 solute carrier family 26 member 3 increases expression ISO salvin results in increased expression of SLC26A3 protein CTD PMID:35926579 NCBI chr 6:53,751,415...53,792,300 JBrowse link
G Slc35a2 solute carrier family 35 member A2 increases expression ISO salvin results in increased expression of SLC35A2 protein CTD PMID:35926579 NCBI chr  X:14,608,145...14,616,937 JBrowse link
G Sltm SAFB-like, transcription modulator decreases expression ISO salvin results in decreased expression of SLTM protein CTD PMID:35926579 NCBI chr 8:71,215,995...71,261,821 JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO salvin results in decreased expression of SNW1 protein CTD PMID:35926579 NCBI chr 6:112,826,374...112,850,459 JBrowse link
G Snx4 sorting nexin 4 decreases expression ISO salvin results in decreased expression of SNX4 protein CTD PMID:35926579 NCBI chr11:80,965,965...81,023,234 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
salvin inhibits the reaction [Acrylamide results in decreased expression of SOD1 mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein] CTD PMID:25446857 PMID:28159594 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein] CTD PMID:24557422 PMID:26577515 PMID:26686574 NCBI chr 1:50,043,323...50,050,168 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in decreased expression of SORBS1 mRNA] CTD PMID:35202923 NCBI chr 1:249,057,324...249,279,703 JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO salvin results in decreased expression of SPARC protein CTD PMID:35926579 NCBI chr10:39,516,394...39,538,252 JBrowse link
G Sprr2a small proline rich protein 2A decreases expression ISO salvin results in decreased expression of SPRR2A protein CTD PMID:35926579 NCBI chr 2:177,815,964...177,816,236 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 decreases expression ISO salvin results in decreased expression of STUB1 protein CTD PMID:35926579 NCBI chr10:14,850,765...14,853,046 JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of TBX3 mRNA] CTD PMID:35202923 NCBI chr12:42,540,378...42,555,490 JBrowse link
G Tep1 telomerase associated protein 1 decreases expression ISO salvin results in decreased expression of TEP1 protein CTD PMID:35926579 NCBI chr15:24,045,876...24,093,526 JBrowse link
G Tf transferrin decreases expression ISO salvin results in decreased expression of TF protein CTD PMID:35926579 NCBI chr 8:103,789,780...103,816,487 JBrowse link
G Tgm3 transglutaminase 3 increases expression ISO salvin results in increased expression of TGM3 protein CTD PMID:35926579 NCBI chr 3:117,228,661...117,264,078 JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:25446857 NCBI chr 1:207,500,959...207,508,276 JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression ISO salvin results in increased expression of TINAGL1 protein CTD PMID:35926579 NCBI chr 5:142,513,710...142,523,730 JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression ISO salvin results in decreased expression of TMED5 protein CTD PMID:35926579 NCBI chr14:1,607,895...1,619,028 JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO salvin results in decreased expression of TMSB4X protein CTD PMID:35926579 NCBI chr  X:30,761,611...30,763,612 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21375325 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnxb tenascin XB increases expression ISO salvin results in increased expression of TNXB protein CTD PMID:35926579
G Tsg101 tumor susceptibility 101 decreases expression ISO salvin results in decreased expression of TSG101 protein CTD PMID:35926579 NCBI chr 1:106,549,035...106,578,859 JBrowse link
G Tspan15 tetraspanin 15 increases expression ISO salvin results in increased expression of TSPAN15 protein CTD PMID:35926579 NCBI chr20:30,130,528...30,174,912 JBrowse link
G Txlna taxilin alpha decreases expression ISO salvin results in decreased expression of TXLNA protein CTD PMID:35926579 NCBI chr 5:141,969,337...141,985,054 JBrowse link
G Tyr tyrosinase decreases expression ISO salvin results in decreased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:150,527,687...150,622,857 JBrowse link
G Ubl4a ubiquitin-like 4A decreases expression ISO salvin results in decreased expression of UBL4A protein CTD PMID:35926579 NCBI chr  X:152,151,242...152,154,094 JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein] CTD PMID:30707903 NCBI chr10:37,029,377...37,060,542 JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression
ISO Calcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein] CTD PMID:11504768 NCBI chr 7:130,864,764...130,916,757 JBrowse link
G Vill villin-like decreases expression ISO salvin results in decreased expression of VILL protein CTD PMID:35926579 NCBI chr 8:118,776,718...118,794,983 JBrowse link
G Wdr5 WD repeat domain 5 decreases expression ISO salvin results in decreased expression of WDR5 protein CTD PMID:35926579 NCBI chr 3:10,836,964...10,856,682 JBrowse link
G Wif1 Wnt inhibitory factor 1 decreases expression ISO salvin results in decreased expression of WIF1 protein CTD PMID:35926579 NCBI chr 7:58,433,326...58,503,853 JBrowse link
G Zfp207 zinc finger protein 207 decreases expression ISO salvin results in decreased expression of ZFP207 protein; salvin results in decreased expression of ZNF207 protein CTD PMID:35926579 NCBI chr10:65,883,630...65,895,895 JBrowse link
Cryptotanshinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO cryptotanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO cryptotanshinone results in decreased expression of ACAT1 mRNA CTD PMID:38936533 NCBI chr 8:53,979,813...54,008,861 JBrowse link
G Ache acetylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of ACHE protein CTD PMID:20350537 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO cryptotanshinone results in decreased expression of ACTA2 mRNA; cryptotanshinone results in decreased expression of ACTA2 protein
CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein]
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
CTD PMID:38936533 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of BCHE protein CTD PMID:20350537 NCBI chr 2:160,607,289...160,699,760 JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO cryptotanshinone results in increased cleavage of CASP3 protein
cryptotanshinone results in increased activity of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein]
CTD PMID:26564229 PMID:28600121 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp7 caspase 7 increases activity ISO cryptotanshinone results in increased activity of CASP7 protein CTD PMID:26564229 NCBI chr 1:265,442,647...265,481,938 JBrowse link
G Casp9 caspase 9 increases activity ISO cryptotanshinone results in increased activity of CASP9 protein CTD PMID:26564229
G Cdh1 cadherin 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] CTD PMID:30208247 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein]
cryptotanshinone results in decreased expression of COL1A1 mRNA; cryptotanshinone results in decreased expression of COL1A1 protein
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
CTD PMID:38936533 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
decreases expression
ISO CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of ACTA2 protein]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 mRNA]; CPT1A protein inhibits the reaction [cryptotanshinone results in decreased expression of COL1A1 protein]
cryptotanshinone results in decreased expression of CPT1A mRNA; cryptotanshinone results in decreased expression of CPT1A protein
CTD PMID:38936533 NCBI chr 1:209,993,881...210,056,329 JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO cryptotanshinone results in decreased expression of CPT1B mRNA CTD PMID:38936533 NCBI chr 7:120,491,354...120,500,833 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] CTD PMID:30208247 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]
cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein
CTD PMID:21262253 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO cryptotanshinone results in increased expression of CYP3A4 protein CTD PMID:18805405 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] CTD PMID:30208247 NCBI chr14:95,378,626...95,551,358 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; cryptotanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] CTD PMID:36804361 PMID:38936533 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] CTD PMID:30208247 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO cryptotanshinone results in decreased phosphorylation of JAK2 protein CTD PMID:38936533 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] CTD PMID:28600121 NCBI chr19:66,571,631...66,582,270 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO cryptotanshinone inhibits the reaction [notoginsenoside R1 results in increased expression of MCL1 protein] CTD PMID:38316350 NCBI chr 2:185,884,840...185,912,532 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:28600121 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cryptotanshinone results in increased activity of NR1I2 protein CTD PMID:18805405 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] CTD PMID:30208247 NCBI chr15:18,215,013...18,228,714 JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] CTD PMID:30208247 NCBI chr 2:56,061,699...56,074,594 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO cryptotanshinone results in decreased activity of PTPN1 protein CTD PMID:29031618 NCBI chr 3:156,638,811...156,687,503 JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO cryptotanshinone results in increased expression of RARB protein CTD PMID:38936533 NCBI chr15:10,837,252...11,482,037 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 PMID:28600121 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO cryptotanshinone results in increased expression of RXRA protein CTD PMID:38936533 NCBI chr 3:31,387,892...31,474,415 JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] CTD PMID:28600121 NCBI chr10:35,026,598...35,037,750 JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions
ISO cryptotanshinone results in decreased phosphorylation of STAT3 protein
cryptotanshinone inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]
cryptotanshinone results in decreased phosphorylation of and affects the localization of STAT3 protein
CTD PMID:28578322 PMID:38936533 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; cryptotanshinone inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] CTD PMID:38936533 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO cryptotanshinone results in decreased expression of TOP2A mRNA
cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein
CTD PMID:28716507 NCBI chr10:84,441,954...84,473,093 JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO cryptotanshinone results in decreased expression of TOP2B mRNA CTD PMID:28716507 NCBI chr15:11,482,089...11,542,464 JBrowse link
Dihydrotanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO dihydrotanshinone I inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid] CTD PMID:35101544 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO dihydrotanshinone I results in decreased expression of ACTA2 protein CTD PMID:38936533 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO dihydrotanshinone I binds to and results in increased activity of AHR protein; dihydrotanshinone I promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO dihydrotanshinone I results in increased phosphorylation of AKT1 protein CTD PMID:26282490 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Casp8 caspase 8 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in decreased expression of CASP8 protein] CTD PMID:29496522 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO dihydrotanshinone I results in decreased expression of COL1A1 protein CTD PMID:38936533 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO dihydrotanshinone I results in increased expression of CYP1A1 mRNA; dihydrotanshinone I results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]
CTD PMID:21262253 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO dihydrotanshinone I results in increased expression of CYP1A2 mRNA; dihydrotanshinone I results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO dihydrotanshinone I results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Eif4e eukaryotic translation initiation factor 4E decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of EIF4E protein CTD PMID:26282490 NCBI chr 2:229,736,309...229,772,628 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:26282490 NCBI chr16:71,495,457...71,508,845 JBrowse link
G Epo erythropoietin multiple interactions ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:26282490 NCBI chr12:19,204,258...19,207,948 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO dihydrotanshinone I inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] CTD PMID:36804361 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO dihydrotanshinone I results in decreased expression of HIF1A protein
dihydrotanshinone I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dihydrotanshinone I inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; dihydrotanshinone I inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]
CTD PMID:26282490 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:29496522 NCBI chr12:11,009,236...11,015,941 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:29496522 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:29496522 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MAPK1 protein CTD PMID:26282490 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MAPK3 protein CTD PMID:26282490 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of MLKL protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MLKL protein] CTD PMID:29496522 NCBI chr19:56,186,860...56,213,886 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein] CTD PMID:29496522 NCBI chr10:73,092,124...73,102,057 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MTOR protein CTD PMID:26282490 NCBI chr 5:164,167,985...164,277,438 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29496522 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29496522 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK1 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK1 protein] CTD PMID:29496522 NCBI chr17:31,044,983...31,077,167 JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK3 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK3 protein] CTD PMID:29496522 NCBI chr15:33,253,071...33,262,025 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of RPS6KB1 protein CTD PMID:26282490 NCBI chr10:71,817,794...71,865,211 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein] CTD PMID:26282490 NCBI chr 5:138,002,522...138,030,742 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein] CTD PMID:29496522 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
dihydrotanshinone I results in decreased expression of VEGFA protein
CTD PMID:26282490 NCBI chr 9:22,452,854...22,468,194 JBrowse link
ferruginol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases activity
ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [ferruginol results in increased activity of CASP3 protein] CTD PMID:30086653 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cat catalase multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:32946155 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Il6 interleukin 6 multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein] CTD PMID:32946155 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO pyrrolidine dithiocarbamic acid inhibits the reaction [ferruginol results in increased expression of RELA protein]; SB 203580 inhibits the reaction [ferruginol results in increased expression of RELA protein] CTD PMID:30086653 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein] CTD PMID:32946155 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32946155 NCBI chr 1:78,342,571...78,346,255 JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:32946155 NCBI chr13:49,819,123...49,837,125 JBrowse link
Miltirone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:35810264 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO miltirone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein]]; miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein] CTD PMID:35810264 NCBI chr11:42,942,742...42,948,399 JBrowse link
Tanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP
ISO
tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 protein]
tanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
CTD PMID:35101544 PMID:35544702 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein] CTD PMID:35243748 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein
[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein]
CTD PMID:35243748 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO tanshinone results in increased expression of ACADVL mRNA CTD PMID:15849732 NCBI chr10:55,231,558...55,236,786 JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO tanshinone results in increased expression of ACSL1 mRNA CTD PMID:15849732 NCBI chr16:45,755,246...45,821,541 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:32097614 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tanshinone binds to and results in increased activity of AHR protein; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]
tanshinone inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]
tanshinone results in increased phosphorylation of AKT1 protein
CTD PMID:34655285 PMID:38348705 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO tanshinone results in decreased expression of ALDH1A3 mRNA CTD PMID:15849732 NCBI chr 1:119,982,272...120,017,416 JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO tanshinone results in decreased expression of ALDH3A2 mRNA CTD PMID:15849732 NCBI chr10:46,427,789...46,448,449 JBrowse link
G Apoc1 apolipoprotein C1 increases expression ISO tanshinone results in increased expression of APOC1 mRNA CTD PMID:15849732 NCBI chr 1:79,347,057...79,350,340 JBrowse link
G Apom apolipoprotein M increases expression ISO tanshinone results in increased expression of APOM mRNA CTD PMID:15849732 NCBI chr20:3,690,950...3,693,550 JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:80,678,027...80,718,273 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO tanshinone results in decreased expression of ASNS mRNA CTD PMID:15849732 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO tanshinone results in decreased expression of ASS1 mRNA CTD PMID:15849732 NCBI chr 3:14,747,355...14,796,909 JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases expression ISO tanshinone results in increased expression of ATP6V0B mRNA CTD PMID:15849732 NCBI chr 5:131,423,384...131,424,900 JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression ISO tanshinone results in increased expression of ATP6V1E1 mRNA CTD PMID:15849732 NCBI chr 4:154,022,358...154,044,486 JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein] CTD PMID:34655285 NCBI chr 1:213,562,719...213,572,034 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tanshinone results in increased expression of BAX protein CTD PMID:21699893 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO tanshinone results in decreased expression of BCKDHB mRNA CTD PMID:15849732 NCBI chr 8:84,845,264...85,027,812 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanshinone results in decreased expression of BCL2 protein CTD PMID:16009009 PMID:19885617 PMID:20369472 PMID:21699893 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO tanshinone results in decreased expression of BIRC3 mRNA CTD PMID:15849732 NCBI chr 8:13,285,702...13,313,329 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of BIRC5 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]
CTD PMID:21165580 NCBI chr10:103,567,369...103,580,069 JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO tanshinone results in increased expression of CALCOCO2 mRNA CTD PMID:15849732 NCBI chr10:81,055,467...81,069,298 JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
ISO
EXP
tanshinone results in increased expression of CASP3 protein
Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]
tanshinone results in increased activity of CASP3 protein
CTD PMID:15849732 PMID:21699893 PMID:34655285 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions ISO tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:26203587 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased expression of CCND1 protein] CTD PMID:35304817 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Cd33 CD33 molecule decreases expression ISO tanshinone results in decreased expression of CD33 protein CTD PMID:16009009 NCBI chr 1:103,071,985...103,086,687 JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO 15-deoxyprostaglandin J2 inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]; tanshinone inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; tanshinone inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]
tanshinone results in decreased expression of CD36 mRNA; tanshinone results in decreased expression of CD36 protein
CTD PMID:20854809 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd68 Cd68 molecule decreases expression ISO tanshinone results in decreased expression of CD68 protein CTD PMID:20854809 NCBI chr10:54,880,562...54,882,441 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein] CTD PMID:32097614 PMID:32886829 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] CTD PMID:18344322 NCBI chr 7:1,714,392...1,721,964 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tanshinone results in increased expression of CDKN1A mRNA CTD PMID:15849732 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] CTD PMID:18344322 NCBI chr 4:169,491,273...169,496,500 JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 decreases expression ISO tanshinone results in decreased expression of CEACAM6 mRNA CTD PMID:15849732 NCBI chr 1:80,416,531...80,434,668 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] CTD PMID:18344322 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO tanshinone results in increased expression of CEBPB protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein]
CTD PMID:18344322 NCBI chr 3:176,817,005...176,818,436 JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] CTD PMID:18344322 NCBI chr15:28,169,711...28,171,471 JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tanshinone results in increased expression of CFLAR protein CTD PMID:26203587 NCBI chr 9:67,679,502...67,747,226 JBrowse link
G Clu clusterin increases expression ISO tanshinone results in increased expression of CLU mRNA CTD PMID:15849732 NCBI chr15:40,161,068...40,200,315 JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO tanshinone results in decreased expression of COL6A1 mRNA CTD PMID:15849732 NCBI chr20:11,905,690...11,924,111 JBrowse link
G Cst6 cystatin E/M increases expression ISO tanshinone results in increased expression of CST6 mRNA CTD PMID:15849732 NCBI chr 1:202,655,322...202,657,030 JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions
ISO tanshinone results in increased expression of CTNNB1 mRNA
[Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein]
CTD PMID:25186638 PMID:32886829 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein] CTD PMID:34655285 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A1 mRNA; tanshinone results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:15849732 PMID:16955220 PMID:21262253 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A2 mRNA; tanshinone results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:21262253 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO tanshinone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO tanshinone results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Dck deoxycytidine kinase increases expression ISO tanshinone results in increased expression of DCK mRNA CTD PMID:15849732 NCBI chr14:19,589,298...19,610,326 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
tanshinone results in increased expression of DDIT3 mRNA; tanshinone results in increased expression of DDIT3 protein
CTD PMID:26203587 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in decreased expression of DUSP1 protein] CTD PMID:29906494 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp11 dual specificity phosphatase 11 increases expression ISO tanshinone results in increased expression of DUSP11 mRNA CTD PMID:15849732 NCBI chr 4:118,367,673...118,385,183 JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO tanshinone results in increased expression of DUSP5 mRNA CTD PMID:15849732 NCBI chr 1:262,543,774...262,557,201 JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases expression ISO tanshinone results in decreased expression of DYRK4 mRNA CTD PMID:15849732 NCBI chr 4:161,401,580...161,443,816 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:28985491 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:28985491 NCBI chr19:47,137,360...47,207,961 JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of EDNRB protein] CTD PMID:28985491 NCBI chr15:87,055,490...87,086,765 JBrowse link
G Elk1 ETS transcription factor ELK1 decreases response to substance
decreases expression
ISO ELK1 mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of ELK1 mRNA
CTD PMID:30506648 NCBI chr  X:3,692,367...3,709,252 JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO tanshinone results in increased expression of ENC1 mRNA CTD PMID:15849732 NCBI chr 2:28,550,670...28,562,591 JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression
multiple interactions
ISO tanshinone results in decreased expression of ERCC1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA]
CTD PMID:21165580 NCBI chr 1:78,971,310...79,007,963 JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO tanshinone results in decreased expression of ETS2 mRNA CTD PMID:15849732 NCBI chr11:48,491,057...48,507,843 JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO tanshinone results in increased expression of F2RL1 mRNA CTD PMID:15849732 NCBI chr 2:28,507,003...28,519,954 JBrowse link
G Flad1 flavin adenine dinucleotide synthetase 1 increases expression ISO tanshinone results in increased expression of FLAD1 mRNA CTD PMID:15849732 NCBI chr 2:174,819,451...174,828,921 JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] CTD PMID:32097614 NCBI chr 9:80,645,507...80,714,200 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO tanshinone results in increased expression of FOS protein
tanshinone results in decreased expression of FOS mRNA
CTD PMID:16009009 PMID:36819991 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Gba1 glucosylceramidase beta 1 increases expression ISO tanshinone results in increased expression of GBA1 mRNA CTD PMID:15849732 NCBI chr 2:176,902,141...176,916,015 JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO tanshinone results in increased expression of GFAP mRNA; tanshinone results in increased expression of GFAP protein CTD PMID:16955220 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO tanshinone inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:38348705 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP [tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein] CTD PMID:34655285 NCBI chr 1:222,852,453...223,098,754 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO tanshinone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; tanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] CTD PMID:36804361 PMID:38348705 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Grb7 growth factor receptor bound protein 7 increases expression ISO tanshinone results in increased expression of GRB7 mRNA CTD PMID:15849732 NCBI chr10:83,443,387...83,453,057 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanshinone results in decreased expression of GSK3B mRNA CTD PMID:25186638 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO tanshinone results in decreased expression of GSTP1 mRNA CTD PMID:21165580 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G H1f2 H1.2 linker histone, cluster member multiple interactions ISO [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] CTD PMID:18344322 NCBI chr17:41,818,962...41,820,453 JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] CTD PMID:18344322 NCBI chr 5:147,138,328...147,165,387 JBrowse link
G Hdac3 histone deacetylase 3 increases expression ISO tanshinone results in increased expression of HDAC3 mRNA CTD PMID:15849732 NCBI chr18:29,770,637...29,789,850 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
tanshinone results in increased expression of HMOX1 protein
tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]
tanshinone promotes the reaction [Silicon Dioxide results in increased expression of HMOX1 protein]
CTD PMID:19356721 PMID:32097614 PMID:38348705 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO tanshinone results in increased expression of ID2 mRNA CTD PMID:15849732 NCBI chr 6:47,469,162...47,470,995 JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP [Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; [IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein; [tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] CTD PMID:34655285 NCBI chr 1:197,814,409...197,831,802 JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions
decreases expression
EXP [IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein
tanshinone results in decreased expression of IGF2R protein
CTD PMID:34655285 NCBI chr 1:50,526,878...50,615,265 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; tanshinone inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:29906494 PMID:35304817 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases activity ISO tanshinone results in decreased activity of IMPDH2 protein CTD PMID:37871880 NCBI chr 8:109,256,705...109,261,365 JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO tanshinone results in increased expression of INPPL1 mRNA CTD PMID:15849732 NCBI chr 1:156,183,043...156,197,500 JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO tanshinone results in increased expression of ISG20 mRNA CTD PMID:15849732 NCBI chr 1:142,234,729...142,246,403 JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO tanshinone results in decreased expression of ITGA6 mRNA CTD PMID:15849732 NCBI chr 3:56,604,512...56,689,428 JBrowse link
G Itgam integrin subunit alpha M increases expression ISO tanshinone results in increased expression of ITGAM protein CTD PMID:16009009 NCBI chr 1:192,089,496...192,139,947 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 NCBI chr 8:19,768,375...19,777,862 JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
multiple interactions
decreases expression
ISO KRAS mRNA results in decreased susceptibility to tanshinone
tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of KRAS protein]
tanshinone results in decreased expression of KRAS mRNA; tanshinone results in decreased expression of KRAS protein
CTD PMID:30506648 PMID:38348705 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of LRP1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]
CTD PMID:21165580 NCBI chr 7:65,265,639...65,346,196 JBrowse link
G Lrp5 LDL receptor related protein 5 decreases expression ISO tanshinone results in decreased expression of LRP5 mRNA CTD PMID:15849732 NCBI chr 1:200,814,247...200,917,581 JBrowse link
G Lrp8 LDL receptor related protein 8 decreases expression ISO tanshinone results in decreased expression of LRP8 mRNA CTD PMID:15849732 NCBI chr 5:127,792,236...127,864,207 JBrowse link
G Maob monoamine oxidase B increases expression ISO tanshinone results in increased expression of MAOB mRNA CTD PMID:15849732 NCBI chr  X:8,490,405...8,594,065 JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO tanshinone results in decreased expression of MAP3K1 mRNA CTD PMID:15849732 NCBI chr 2:45,081,889...45,150,555 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:29906494 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:29906494 NCBI chr10:34,670,750...34,711,972 JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO tanshinone results in decreased expression of MIPEP mRNA CTD PMID:15849732 NCBI chr15:34,926,198...35,051,722 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased expression of MIR21 protein] CTD PMID:35304817 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 8:12,943,453...12,963,966 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein] CTD PMID:32886829 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO tanshinone results in decreased expression of MMP7 mRNA CTD PMID:15849732 NCBI chr 8:13,133,043...13,140,761 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein] CTD PMID:24929186 PMID:32886829 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Msr1 macrophage scavenger receptor 1 decreases expression ISO tanshinone results in decreased expression of MSR1 mRNA CTD PMID:20854809 NCBI chr16:52,717,775...52,803,602 JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO tanshinone results in increased expression of MYBL2 mRNA CTD PMID:15849732 NCBI chr 3:172,124,765...172,153,221 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tanshinone results in decreased expression of MYC protein
[Doxorubicin co-treated with tanshinone] affects the expression of MYC protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MYC protein]
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein]
tanshinone results in decreased expression of MYC mRNA; tanshinone results in decreased expression of MYC protein
CTD PMID:16009009 PMID:18344322 PMID:21699893 PMID:32886829 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO tanshinone results in increased expression of MYL1 mRNA CTD PMID:15849732 NCBI chr 9:68,437,514...68,458,256 JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit increases expression ISO tanshinone results in increased expression of NAA10 mRNA CTD PMID:15849732 NCBI chr  X:156,807,378...156,812,632 JBrowse link
G Nanog Nanog homeobox multiple interactions
increases expression
EXP
ISO
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of NANOG protein]
tanshinone results in increased expression of NANOG mRNA
CTD PMID:25186638 PMID:31108107 NCBI chr 4:155,943,737...155,951,116 JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO tanshinone results in increased expression of NDUFB2 mRNA CTD PMID:15849732 NCBI chr 4:69,334,307...69,341,394 JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression ISO tanshinone results in increased expression of NDUFV1 mRNA CTD PMID:15849732 NCBI chr 1:201,300,365...201,305,461 JBrowse link
G Nes nestin decreases expression ISO tanshinone results in decreased expression of NES mRNA; tanshinone results in decreased expression of NES protein CTD PMID:16955220 NCBI chr 2:175,735,715...175,745,631 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP
[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein]
[tanshinone co-treated with Rifampin] results in increased expression of NFE2L2 mRNA; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 protein]
[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein]; tanshinone inhibits the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]; tanshinone promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]
CTD PMID:32097614 PMID:33307820 PMID:35243748 PMID:38348705 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:29906494 PMID:30268796 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] CTD PMID:23500011 PMID:24239652 PMID:29906494 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of NOS3 mRNA; tanshinone results in increased expression of NOS3 protein
HC-067047 inhibits the reaction [tanshinone results in increased expression of NOS3 protein]
tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]
CTD PMID:15849732 PMID:28985491 PMID:39089414 NCBI chr 4:11,686,088...11,706,604 JBrowse link
G Nppb natriuretic peptide B decreases expression ISO tanshinone results in decreased expression of NPPB protein CTD PMID:37643320 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NQO1 protein] CTD PMID:32097614 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO tanshinone results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]
CTD PMID:18805405 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr13:86,165,327...86,170,362 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO tanshinone results in decreased expression of OLR1 mRNA; tanshinone results in decreased expression of OLR1 protein CTD PMID:22677363 NCBI chr 4:164,612,460...164,635,082 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] CTD PMID:26203587 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO tanshinone results in increased expression of PARP4 mRNA CTD PMID:15849732 PMID:16955220 NCBI chr15:34,806,203...34,908,492 JBrowse link
G Pcsk7 proprotein convertase subtilisin/kexin type 7 increases expression ISO tanshinone results in increased expression of PCSK7 mRNA CTD PMID:15849732 NCBI chr 8:55,098,821...55,121,416 JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression
multiple interactions
EXP tanshinone results in increased expression of PHGDH mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in increased methylation of PHGDH promoter]
CTD PMID:31108107 NCBI chr 2:185,906,962...185,936,054 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein] CTD PMID:34655285 NCBI chr 2:34,612,946...34,697,660 JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO tanshinone results in decreased expression of PLOD2 mRNA CTD PMID:15849732 NCBI chr 8:93,084,548...93,167,255 JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of POU5F1 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of POU5F1 protein]
CTD PMID:25186638 PMID:31108107 NCBI chr20:3,227,836...3,232,598 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO tanshinone results in decreased expression of PPARG mRNA CTD PMID:20854809 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions EXP [Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] CTD PMID:34655285 NCBI chr 2:227,839,058...228,113,560 JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 multiple interactions ISO [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein CTD PMID:18344322 NCBI chr 7:14,428,548...14,438,081 JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression
multiple interactions
EXP tanshinone results in increased expression of PRKG1 protein
[HC-067047 co-treated with tanshinone] results in decreased expression of PRKG1 protein
CTD PMID:39089414 NCBI chr 1:237,818,950...239,052,184 JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression ISO tanshinone results in decreased expression of PRPF6 mRNA CTD PMID:15849732 NCBI chr 3:189,084,465...189,148,705 JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO tanshinone results in increased expression of PSMB5 mRNA CTD PMID:15849732 NCBI chr15:32,042,784...32,047,379 JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO tanshinone results in increased expression of PSMD2 mRNA CTD PMID:15849732 NCBI chr11:80,248,364...80,258,991 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tanshinone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]
tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:22288910 PMID:23500011 PMID:24239652 PMID:24967690 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO tanshinone results in decreased expression of PTPRK mRNA CTD PMID:15849732 NCBI chr 1:18,557,091...19,056,297 JBrowse link
G Ptx3 pentraxin 3 decreases secretion
decreases expression
multiple interactions
ISO tanshinone results in decreased secretion of PTX3 protein
tanshinone results in decreased expression of PTX3 mRNA
tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein]
CTD PMID:30268796 NCBI chr 2:152,797,563...152,803,372 JBrowse link
G Rarb retinoic acid receptor, beta increases expression
multiple interactions
ISO tanshinone results in increased expression of RARB mRNA
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]
CTD PMID:18344322 NCBI chr15:10,837,252...11,482,037 JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein; [tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein
tanshinone results in increased expression of RB1 protein
CTD PMID:18344322 NCBI chr15:54,780,858...54,911,989 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein] CTD PMID:30268796 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rhoc ras homolog family member C increases expression ISO tanshinone results in increased expression of RHOC mRNA CTD PMID:15849732 NCBI chr 2:192,287,065...192,293,292 JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO tanshinone results in increased expression of SEPHS2 mRNA CTD PMID:15849732 NCBI chr 1:191,323,637...191,325,955 JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP [tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 mRNA; [tanshinone co-treated with Rifampin] results in increased expression of SLC10A1 protein; tanshinone inhibits the reaction [Rifampin results in decreased expression of SLC10A1 protein] CTD PMID:33307820 NCBI chr 6:100,613,045...100,626,670 JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein] CTD PMID:32097614 NCBI chr18:71,263,508...71,291,849 JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of SOX2 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of SOX2 protein]
CTD PMID:25186638 PMID:31108107 NCBI chr 2:117,536,929...117,539,340 JBrowse link
G Sp2 Sp2 transcription factor decreases expression ISO tanshinone results in decreased expression of SP2 mRNA CTD PMID:15849732 NCBI chr10:81,940,580...81,970,040 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:5,613,569...5,620,695 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein] CTD PMID:35304817 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Tesk1 testis associated actin remodelling kinase 1 increases expression ISO tanshinone results in increased expression of TESK1 mRNA CTD PMID:15849732 NCBI chr 5:62,487,763...62,493,492 JBrowse link
G Tfap4 transcription factor AP-4 decreases expression ISO tanshinone results in decreased expression of TFAP4 mRNA CTD PMID:15849732 NCBI chr10:11,001,338...11,019,386 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]
tanshinone results in increased expression of TGFB1 protein
CTD PMID:32097614 PMID:37643320 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO tanshinone results in increased expression of TK1 mRNA CTD PMID:15849732 NCBI chr10:103,533,449...103,544,818 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]; tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] CTD PMID:29906494 PMID:30268796 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein]
tanshinone results in increased susceptibility to TNFSF10 protein
CTD PMID:26203587 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO tanshinone results in increased expression of TP53 protein
tanshinone results in decreased expression of TRP53 mRNA
tanshinone results in decreased expression of TP53 protein
CTD PMID:16009009 PMID:19885617 PMID:20369472 PMID:36819991 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions
increases expression
ISO
EXP
HC-067047 inhibits the reaction [tanshinone results in increased expression of and results in increased activity of TRPV4 protein]; tanshinone inhibits the reaction [Cycloheximide results in increased degradation of TRPV4 protein]; tanshinone results in increased expression of and results in increased activity of TRPV4 protein
tanshinone results in increased expression of TRPV4 mRNA
tanshinone results in increased expression of TRPV4 mRNA; tanshinone results in increased expression of TRPV4 protein
CTD PMID:39089414 NCBI chr12:47,599,161...47,638,143 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO tanshinone results in increased expression of VEGFA mRNA; tanshinone results in increased expression of VEGFA protein CTD PMID:25186638 PMID:37643320 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Vim vimentin multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:32097614 NCBI chr17:81,577,261...81,585,746 JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 increases expression ISO tanshinone results in increased expression of WFDC2 mRNA CTD PMID:15849732 NCBI chr 3:153,286,946...153,314,832 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      atom 19896
        nonmetal atom 19818
          carbon atom 19770
            organic molecular entity 19770
              isoprenoid 14082
                terpenoid 13783
                  diterpenoid 13046
                    abietane diterpenoid 420
                      (+)-(5S,6S,10R)-12-hydroxy-7-oxo-abieta-8,11,13-trien-20-oic acid6,20-lactone 0
                      (+)-(5S,6S,7R,10R)-6,7,12-trihydroxyabieta-8,11,13-trien-20-oic acid 6,20-lactone 0
                      (+)-(5S,6S,7S,8R,10R)-6-hydroxy-7,8-epoxy-12-oxo-abieta-9(11),13-dien-20-oic acid 6,20-lactone 0
                      (+)-pisiferal 0
                      (+)-pisiferic acid 0
                      (-)-(4S,5S,10R)-12,18-dihydroxyabieta-8,11,13-trien-20-oic acid-18,20-lactone 0
                      (-)-(4S,5S,10R,20R)-12,18-dihydroxy-7-oxo-abieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                      (-)-(4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                      (-)-(4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde18,20-methyl acetal 0
                      (-)-(4S,5S,10R,20S)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-methyl acetal 0
                      (-)-(4S,5S,7S,10R,20S)-7,12,18-trihydroxyabieta-8,11,13-trien-20-aldehyde 7,18,20-acetal 0
                      (-)-(4S,5S,8R,10R)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid 18,20-lactone 0
                      (-)-(4S,5S,8R,10R,20S)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-aldehyde 8,18,20-acetal 0
                      (-)-(5S,6S,7S,10R)-6,7,12-trihydroxyabieta-8,11,13-trien-20-oic acid 6,20-lactone 0
                      (10S)-12,16-epoxy-17(15->16)-abeo-3,5,8,12,15-abietapentaen-2,7,11,14-tetraone 0
                      (4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-hemiacetal 0
                      (4S,5S,10R,20S)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-hemiacetal 0
                      1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione 0
                      11,20-dihydroxyferruginol + 0
                      11,20-dihydroxysugiol 0
                      11-hydroxyferruginol 0
                      11-hydroxysugiol + 0
                      11-oxomiltiradiene 0
                      12-methyl-5-dehydroacetylhorminone 0
                      12-methyl-5-dehydrohorminone + 0
                      6-Methylcryptotanshinone [14,16-epoxy-6-methyl-5(10),6,8,13-abietatetraene-11,12-dione] 0
                      7-dehydroabietanone 0
                      8-hydroxy-12-oxoabieta-9(11),13-dien-20-oic 8,20-lactone 0
                      Cryptotanshinone 38
                      Dihydrotanshinone I 30
                      Hydroxytanshinone 0
                      Metamycin C 0
                      Metamycin D 0
                      Methyl tanshinonate 0
                      Miltirone 3
                      Tanshinone I 162
                      abietal 0
                      abietate 0
                      abietic acid + 5
                      abietol 0
                      carnosate 0
                      carnosic acid 250
                      cycloinumakiol 0
                      dehydroabietadienal 0
                      dehydroabietadienol 0
                      dehydroabietic acid 0
                      ferruginol + 7
                      gelomulide K 0
                      gelomulide M 0
                      horminone + 0
                      inumakal 0
                      inumakoic acid 0
                      levopimaradienal 0
                      levopimaradienol 0
                      miltiradien-20-al 0
                      podocarpic acid 0
                      rubesanolide D 0
                      salviol 0
                      sugiol + 0
                      triptobenzene A 0
                      triptobenzene D 0
                      triptobenzene H 0
                      triptonoterpene 0
                      triptonoterpene methyl ether 0
                      triptoquinone A 0
                      triptoquinone B 0
                      triptoquinone H 0
                      triptriolide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            organic hydride 18711
                              organic fundamental parent 18711
                                hydrocarbon 18462
                                  terpene 14082
                                    terpenoid 13783
                                      diterpenoid 13046
                                        abietane diterpenoid 420
                                          (+)-(5S,6S,10R)-12-hydroxy-7-oxo-abieta-8,11,13-trien-20-oic acid6,20-lactone 0
                                          (+)-(5S,6S,7R,10R)-6,7,12-trihydroxyabieta-8,11,13-trien-20-oic acid 6,20-lactone 0
                                          (+)-(5S,6S,7S,8R,10R)-6-hydroxy-7,8-epoxy-12-oxo-abieta-9(11),13-dien-20-oic acid 6,20-lactone 0
                                          (+)-pisiferal 0
                                          (+)-pisiferic acid 0
                                          (-)-(4S,5S,10R)-12,18-dihydroxyabieta-8,11,13-trien-20-oic acid-18,20-lactone 0
                                          (-)-(4S,5S,10R,20R)-12,18-dihydroxy-7-oxo-abieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                                          (-)-(4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-ethyl acetal 0
                                          (-)-(4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde18,20-methyl acetal 0
                                          (-)-(4S,5S,10R,20S)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-methyl acetal 0
                                          (-)-(4S,5S,7S,10R,20S)-7,12,18-trihydroxyabieta-8,11,13-trien-20-aldehyde 7,18,20-acetal 0
                                          (-)-(4S,5S,8R,10R)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid 18,20-lactone 0
                                          (-)-(4S,5S,8R,10R,20S)-8,18-dihydroxy-12-oxo-abieta-9(11),13-dien-20-aldehyde 8,18,20-acetal 0
                                          (-)-(5S,6S,7S,10R)-6,7,12-trihydroxyabieta-8,11,13-trien-20-oic acid 6,20-lactone 0
                                          (10S)-12,16-epoxy-17(15->16)-abeo-3,5,8,12,15-abietapentaen-2,7,11,14-tetraone 0
                                          (4S,5S,10R,20R)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-hemiacetal 0
                                          (4S,5S,10R,20S)-12,18-dihydroxyabieta-8,11,13-trien-20-aldehyde 18,20-hemiacetal 0
                                          1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione 0
                                          11,20-dihydroxyferruginol + 0
                                          11,20-dihydroxysugiol 0
                                          11-hydroxyferruginol 0
                                          11-hydroxysugiol + 0
                                          11-oxomiltiradiene 0
                                          12-methyl-5-dehydroacetylhorminone 0
                                          12-methyl-5-dehydrohorminone + 0
                                          6-Methylcryptotanshinone [14,16-epoxy-6-methyl-5(10),6,8,13-abietatetraene-11,12-dione] 0
                                          7-dehydroabietanone 0
                                          8-hydroxy-12-oxoabieta-9(11),13-dien-20-oic 8,20-lactone 0
                                          Cryptotanshinone 38
                                          Dihydrotanshinone I 30
                                          Hydroxytanshinone 0
                                          Metamycin C 0
                                          Metamycin D 0
                                          Methyl tanshinonate 0
                                          Miltirone 3
                                          Tanshinone I 162
                                          abietal 0
                                          abietate 0
                                          abietic acid + 5
                                          abietol 0
                                          carnosate 0
                                          carnosic acid 250
                                          cycloinumakiol 0
                                          dehydroabietadienal 0
                                          dehydroabietadienol 0
                                          dehydroabietic acid 0
                                          ferruginol + 7
                                          gelomulide K 0
                                          gelomulide M 0
                                          horminone + 0
                                          inumakal 0
                                          inumakoic acid 0
                                          levopimaradienal 0
                                          levopimaradienol 0
                                          miltiradien-20-al 0
                                          podocarpic acid 0
                                          rubesanolide D 0
                                          salviol 0
                                          sugiol + 0
                                          triptobenzene A 0
                                          triptobenzene D 0
                                          triptobenzene H 0
                                          triptonoterpene 0
                                          triptonoterpene methyl ether 0
                                          triptoquinone A 0
                                          triptoquinone B 0
                                          triptoquinone H 0
                                          triptriolide 0
paths to the root