CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dichlorobiphenyl
Accession: CHEBI:36718
browse the term
Definition: Any polychlorobiphenyl with molecular formula C12H8Cl2.
Synonyms: exact_synonym: dichloro-1,1'-biphenyl
related_synonym: Formula=C12H8Cl2
G
Ar
androgen receptor
affects binding multiple interactions
ISO
2,4'-dichlorobiphenyl binds to AR protein 2,4'-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:14565775 PMID:18324785
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
2,4'-dichlorobiphenyl results in increased activity of NR1I3 protein
CTD
PMID:26231822
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
G
Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
multiple interactions affects binding
ISO
2,4'-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone] 2,4'-dichlorobiphenyl metabolite binds to SULT2A1 protein
CTD
PMID:24508592
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
2,5-dichlorobiphenyl analog results in increased activity of NR1I3 protein; 2,5-dichlorobiphenyl results in increased activity of NR1I3 protein
CTD
PMID:26231822
NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
G
Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
multiple interactions
ISO
2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein affects the metabolism of Dehydroepiandrosterone]; 2,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
CTD
PMID:17112228 PMID:24508592
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
G
Ar
androgen receptor
multiple interactions
ISO
2,6-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
G
Ar
androgen receptor
multiple interactions
ISO
3,5-dichlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:18324785
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
G
Mapk1
mitogen-activated protein kinase 1
increases response to substance
ISO
MAPK1 protein modified form results in increased susceptibility to 3,5-dichlorobiphenyl analog
CTD
PMID:19631230
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
increases response to substance
ISO
MAPK3 protein modified form results in increased susceptibility to 3,5-dichlorobiphenyl analog
CTD
PMID:19631230
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
multiple interactions
ISO
3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to SERPINA7 protein]
CTD
PMID:16478101
NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985
G
Sult2a1
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
affects binding multiple interactions
ISO
3,5-dichlorobiphenyl metabolite binds to SULT2A1 protein 3,5-dichlorobiphenyl metabolite inhibits the reaction [SULT2A1 protein results in increased sulfation of Dehydroepiandrosterone]
CTD
PMID:24508592
NCBI chr 7:13,530,171...13,571,335
Ensembl chr 7:13,530,171...13,571,334
G
Ttr
transthyretin
multiple interactions
ISO
3,5-dichlorobiphenyl metabolite inhibits the reaction [Thyroxine binds to TTR protein]
CTD
PMID:16478101
NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378
G
Lamp3
lysosomal-associated membrane protein 3
decreases expression
ISO
4,4'-dichlorobiphenyl results in decreased expression of LAMP3 mRNA
CTD
PMID:20678512
NCBI chr16:19,472,131...19,525,115
Ensembl chr16:19,472,128...19,525,125
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
22307
role
22293
chemical role
21547
environmental contaminant
20144
persistent organic pollutant
17806
polychlorobiphenyl
6305
dichlorobiphenyl
8
2,4'-dichlorobiphenyl
3
2,5-dichlorobiphenyl
2
2,6-dichlorobiphenyl
1
3,5-dichlorobiphenyl
6
4,4'-dichlorobiphenyl
1
Path 2
CHEBI ontology
22307
subatomic particle
22302
composite particle
22302
hadron
22302
baryon
22302
nucleon
22302
atomic nucleus
22302
atom
22302
main group element atom
22184
main group molecular entity
22184
s-block molecular entity
21804
hydrogen molecular entity
21721
hydrides
20775
organic hydride
20321
organic fundamental parent
20321
hydrocarbon
19903
halohydrocarbon
16593
haloarene
6677
chloroarene
6307
chlorobiphenyl
6307
polychlorobiphenyl
6305
dichlorobiphenyl
8
2,4'-dichlorobiphenyl
3
2,5-dichlorobiphenyl
2
2,6-dichlorobiphenyl
1
3,5-dichlorobiphenyl
6
4,4'-dichlorobiphenyl
1