aminoquinoline - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	aminoquinoline	go back to main search page
Accession:	CHEBI:36709	browse the term
Definition:	Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups.
Synonyms:	related_synonym:	aminoquinolines

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Rat (1743) Mouse (1722) Human (1731) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (15) Green Monkey (0) Naked Mole-rat (0) All
Genes (1743)

2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

amiridine results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

butyrylcholinesterase

decreases activity

amiridine results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

6-anilino-5,8-quinolinedione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

decreases response to substance

BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

heat shock protein 90 alpha family class A member 1

multiple interactions

6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

increases expression

6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

interleukin 4

decreases secretion

6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

decreases secretion

6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

6-anilino-5,8-quinolinedione inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

vascular endothelial growth factor A

multiple interactions

6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

amodiaquine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Amodiaquine results in decreased expression of BCL2 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 6

increases expression

Amodiaquine results in increased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

caspase 3

increases cleavage

Amodiaquine results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

affects expression

Amodiaquine affects the expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

affects expression

Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cytotoxic T-lymphocyte-associated protein 4

multiple interactions

CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]

NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963

G

cathepsin B

decreases activity

Amodiaquine results in decreased activity of CTSB protein

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

decreases activity

Amodiaquine results in decreased activity of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin L

decreases activity

Amodiaquine results in decreased activity of CTSL protein

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
decreases response to substance
increases metabolic processing

Amodiaquine results in increased activity of CYP1A1 protein
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CYP1A1 protein results in decreased susceptibility to Amodiaquine

PMID:12451431 PMID:31629065

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases metabolic processing
multiple interactions

Amodiaquine results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Amodiaquine
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine

PMID:11124226 PMID:26599973 PMID:31629065

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases response to substance
increases metabolic processing
multiple interactions

CYP1B1 protein results in decreased susceptibility to Amodiaquine
CYP1B1 protein results in increased metabolism of Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases metabolic processing
multiple interactions

CYP2A13 protein results in increased metabolism of Amodiaquine
[CYP2A13 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases metabolic processing

[CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
increases metabolic processing

[CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity
increases metabolic processing
multiple interactions

Amodiaquine results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of Amodiaquine
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

PMID:11124226 PMID:31629065

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

multiple interactions
increases response to substance
increases metabolic processing
affects metabolic processing

[5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CYP2C8 protein affects the metabolism of Amodiaquine

PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More...

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
multiple interactions

CYP2D6 protein results in increased metabolism of Amodiaquine
[CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine

PMID:28478157 PMID:31629065 PMID:33259822

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases metabolic processing

[CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases metabolic processing
increases response to substance

[CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]

PMID:28478157 PMID:31629065

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing
multiple interactions

CYP3A5 protein results in increased metabolism of Amodiaquine
[CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

E2F transcription factor 1

affects expression

Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

epiregulin

increases expression

Amodiaquine results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

glutamic--pyruvic transaminase

multiple interactions

[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 1 alpha

decreases expression

Amodiaquine results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

lymphocyte activating 3

multiple interactions

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]

NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404

G

mitogen activated protein kinase 1

multiple interactions

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

Amodiaquine results in increased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

myeloperoxidase

affects response to substance

MPO protein affects the susceptibility to Amodiaquine

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3]

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

Amodiaquine binds to and results in increased activity of NR4A2 protein

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

programmed cell death 1

multiple interactions

[PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937

G

phosphotyrosine interaction domain containing 1

increases expression

Amodiaquine results in increased expression of PID1 mRNA

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

prostaglandin-endoperoxide synthase 2

decreases expression

Amodiaquine results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

affects phosphorylation

Amodiaquine affects the phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

transforming growth factor, beta 1

multiple interactions

[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TNF alpha induced protein 6

decreases expression

Amodiaquine results in decreased expression of TNFAIP6 mRNA

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

tumor protein p53

increases activity
affects expression

Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein

PMID:12082016 PMID:24113242

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

bosutinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

decreases activity

bosutinib results in decreased activity of ABL1 protein

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

AKT serine/threonine kinase 1

decreases phosphorylation
decreases expression

bosutinib results in decreased phosphorylation of AKT1 protein
bosutinib results in decreased expression of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

cyclin D1

decreases expression
multiple interactions

bosutinib results in decreased expression of CCND1 protein
[SM 164 co-treated with bosutinib] results in decreased expression of CCND1 protein

PMID:16489032 PMID:22241084

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

affects localization
multiple interactions

bosutinib affects the localization of CCND3 protein
[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cell division cycle 25A

decreases expression
multiple interactions

bosutinib results in decreased expression of CDC25A protein
Imatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cadherin 1

multiple interactions

bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin dependent kinase 2

decreases activity
decreases expression

bosutinib results in decreased activity of CDK2 protein
bosutinib results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

bosutinib results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

bosutinib results in increased expression of CDKN1B protein
Imatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

C-terminal Src kinase

decreases activity

bosutinib results in decreased activity of CSK protein

NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292

G

catenin beta 1

affects localization
decreases phosphorylation
multiple interactions

bosutinib affects the localization of CTNNB1 protein
bosutinib results in decreased phosphorylation of CTNNB1 protein
bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]; bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

epidermal growth factor receptor

decreases activity

bosutinib results in decreased activity of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

erb-b2 receptor tyrosine kinase 2

decreases phosphorylation

bosutinib results in decreased phosphorylation of ERBB2 protein

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

FGR proto-oncogene, Src family tyrosine kinase

decreases activity

bosutinib results in decreased activity of FGR protein

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

glutamic--pyruvic transaminase

increases secretion

bosutinib results in increased secretion of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

LYN proto-oncogene, Src family tyrosine kinase

decreases activity

bosutinib results in decreased activity of LYN protein

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

mitogen-activated protein kinase 8

multiple interactions

bosutinib affects the reaction [linsidomine results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

poly (ADP-ribose) polymerase 1

multiple interactions

[bosutinib co-treated with linsidomine] affects the expression of PARP1 protein; bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

solute carrier family 16 member 2

multiple interactions

bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]

NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation
multiple interactions

bosutinib results in decreased phosphorylation of SRC protein
bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

transcription factor 4

multiple interactions

bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]

NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425

G

tumor protein p53

affects activity

bosutinib analog affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

chloroquine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression
multiple interactions

Chloroquine results in decreased expression of ABCB1 mRNA; Chloroquine results in decreased expression of ABCB1 protein
Chloroquine results in decreased expression of ABCB1A mRNA
[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein; Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1A mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1A mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]
Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1 mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein

PMID:25987058 PMID:27692344 PMID:30482226

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

decreases expression

Chloroquine results in decreased expression of ABCC1 mRNA; Chloroquine results in decreased expression of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases expression

Chloroquine results in decreased expression of ABCC2 mRNA; Chloroquine results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

decreases expression

Chloroquine results in decreased expression of ABCG2 mRNA; Chloroquine results in decreased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

Chloroquine inhibits the reaction [Particulate Matter results in increased expression of ACSL4 protein]

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

actin alpha 2, smooth muscle

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]]
Chloroquine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]

PMID:35104487 PMID:38477077

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of AKT1 protein]
Chloroquine results in decreased phosphorylation of AKT1 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]

PMID:24990399 PMID:27180204

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

multiple interactions

Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

Chloroquine results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

angiopoietin-like 8

multiple interactions

Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]

NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490

G

apolipoprotein D

affects localization

Chloroquine affects the localization of APOD protein

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

apolipoprotein E

affects localization

Chloroquine affects the localization of APOE protein

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

affects expression
multiple interactions
affects localization
increases expression

Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein
Chloroquine affects the localization of and affects the cleavage of APP protein
Chloroquine affects the localization of APP protein
Chloroquine results in increased expression of APP protein

PMID:7715800 PMID:8616629 PMID:8787835 PMID:9690670

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

multiple interactions

Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]

NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692

G

aquaporin 2

decreases degradation
multiple interactions
decreases expression

Chloroquine results in decreased degradation of AQP2 protein
Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]
Chloroquine results in decreased expression of AQP2 protein

PMID:21734099 PMID:22791344

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

aquaporin 5

multiple interactions

Chloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein]

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

androgen receptor

multiple interactions

Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

archain 1

affects localization

Chloroquine affects the localization of ARCN1 protein

NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247

G

argininosuccinate synthase 1

decreases expression

Chloroquine results in decreased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 4

multiple interactions

Chloroquine promotes the reaction [cadmium acetate results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

autophagy related 5

multiple interactions
increases expression

Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of ATG5 protein]
Chloroquine results in increased expression of ATG5 protein
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of ATG5 protein]

PMID:28184909 PMID:29870746 PMID:30338810

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATM serine/threonine kinase

increases phosphorylation

Chloroquine results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression

Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]
Chloroquine results in increased expression of ATP1A1 protein

PMID:10506578 PMID:26750564

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

arginine vasopressin

multiple interactions

Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]; Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

multiple interactions

BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]]
Chloroquine affects the folding of and results in increased activity of BAX protein; Chloroquine inhibits the reaction [formosanin C results in increased expression of BAX protein]; Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]

PMID:11589424 PMID:23151917 PMID:27180204 PMID:28713934 PMID:33684387 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

Chloroquine results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions

Chloroquine inhibits the reaction [formosanin C results in decreased expression of BCL2 protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]

PMID:27180204 PMID:28713934 PMID:35104487

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression

BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine results in increased expression of BCL2L1 mRNA

PMID:11589424 PMID:31310755

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

multiple interactions
decreases expression

Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein]
Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 mRNA]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BECN1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]]
Chloroquine results in decreased expression of BECN1 mRNA; Chloroquine results in decreased expression of BECN1 protein

PMID:25987058 PMID:27692344 PMID:28184909 PMID:29870746 PMID:31862506 More...

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions

Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

baculoviral IAP repeat-containing 5

multiple interactions

Chloroquine promotes the reaction [sunitinib results in decreased expression of BIRC5 protein]
Chloroquine promotes the reaction [Immunologic Factors results in decreased expression of BIRC5 protein]

PMID:24751611 PMID:27823620

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

multiple interactions
increases expression

vistusertib inhibits the reaction [Chloroquine results in increased expression of BNIP3 protein]

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

beta-transducin repeat containing E3 ubiquitin protein ligase

multiple interactions

Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC protein]

NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721

G

calreticulin

increases expression
multiple interactions

Chloroquine results in increased expression of CALR mRNA
[CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein; [Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Chloroquine results in increased expression of and affects the localization of CALR protein; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; Doxorubicin promotes the reaction [Chloroquine affects the localization of CALR protein]
[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 12

multiple interactions

Chloroquine promotes the reaction [cadmium acetate results in increased expression of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]
Chloroquine results in increased expression of CASP3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with aumolertinib] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with vandetanib] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]

PMID:11589424 PMID:23151917 PMID:23799852 PMID:24751611 PMID:25078063 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases cleavage
multiple interactions

Chloroquine results in increased cleavage of CASP8 protein
Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein]
Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]

PMID:27692344 PMID:28906492 PMID:29111403

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

[Chloroquine co-treated with vandetanib] results in increased activity of CASP9 protein; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein]

PMID:23151917 PMID:23799852 PMID:28184909 PMID:28906492

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calcium-sensing receptor

multiple interactions

Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR protein]

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

catalase

decreases activity
multiple interactions
decreases expression

Chloroquine results in decreased activity of CAT protein
Chloroquine promotes the reaction [sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA]
Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]
Chloroquine results in decreased expression of CAT protein

PMID:15526909 PMID:17076682 PMID:23607047 PMID:24751611

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 1

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL1 protein]

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 11

decreases secretion
multiple interactions

Chloroquine results in decreased secretion of CCL11 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL11 protein]

PMID:22341560 PMID:29772762

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

increases expression
multiple interactions
decreases secretion

Chloroquine results in increased expression of CCL2 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein]
Chloroquine results in decreased secretion of CCL2 protein
Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of MCP1 protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]

PMID:15139008 PMID:22341560 PMID:29772762 PMID:35561756

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 25

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein]

NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554

G

C-C motif chemokine ligand 5

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression
multiple interactions

Chloroquine results in increased expression of CCN1 mRNA
Chloroquine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]

PMID:19393257 PMID:34405320

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

CD274 molecule

decreases expression

Chloroquine results in decreased expression of CD274 protein

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD34 molecule

multiple interactions

Chloroquine promotes the reaction [sunitinib results in decreased expression of CD34 protein]

NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832

G

cadherin 1

multiple interactions

Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase inhibitor 1A

increases activity
multiple interactions
increases expression

Chloroquine results in increased activity of CDKN1A
[Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]
Chloroquine results in increased expression of CDKN1A protein

PMID:12243503 PMID:18089834 PMID:22927544 PMID:30025493

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]]

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

CCAAT/enhancer binding protein beta

multiple interactions
increases expression

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

component of inhibitor of nuclear factor kappa B kinase complex

decreases expression

Chloroquine results in decreased expression of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cellular inhibitor of PP2A

multiple interactions

Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein]

NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938

G

claudin 1

increases expression

Chloroquine results in increased expression of CLDN1 mRNA

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

claudin 2

multiple interactions

Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

clusterin

affects localization

Chloroquine affects the localization of CLU protein

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type I alpha 1 chain

multiple interactions

Chloroquine inhibits the reaction [sodium arsenite results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

coenzyme Q6 monooxygenase

decreases expression

Chloroquine results in decreased expression of COQ6 mRNA

NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657

G

cytochrome c oxidase subunit 4i1

multiple interactions

Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein]

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

citrate synthase

multiple interactions

Chloroquine affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein]

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

catenin beta 1

multiple interactions

Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

chymotrypsinogen B1

decreases expression

Chloroquine results in decreased expression of CTRB1 mRNA

NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688

G

cathepsin A

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein

NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215

G

cathepsin B

increases expression
multiple interactions
decreases activity

Chloroquine results in increased expression of CTSB protein
Chloroquine promotes the reaction [Arsenic results in increased activity of CTSB protein]
Chloroquine results in decreased activity of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]

PMID:2759144 PMID:23151917 PMID:30338810 PMID:30821613 PMID:36117518

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

affects localization
multiple interactions
increases expression

Chloroquine affects the localization of CTSD protein
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein
Chloroquine results in increased expression of CTSD protein

PMID:2759144 PMID:7715800 PMID:30821613

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

multiple interactions

Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK protein]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin L

increases expression

Chloroquine results in increased expression of CTSL protein

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 10

multiple interactions

Chloroquine inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL9 protein]

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Chloroquine results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

Chloroquine results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily c, polypeptide 79

affects metabolic processing
multiple interactions
increases metabolic processing

CYP2C8 polymorphism affects the metabolism of Chloroquine; CYP2C8 protein affects the metabolism of Chloroquine
[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]

PMID:12756207 PMID:12920490 PMID:12967198 PMID:17286541 PMID:19560616

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
decreases activity
multiple interactions

CYP2D6 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine

PMID:12756207 PMID:12920490

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
affects metabolic processing
decreases activity

[CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
CYP3A4 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP3A4 protein

PMID:11124226 PMID:12756207 PMID:12920490

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Chloroquine promotes the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein]
Chloroquine results in increased expression of DDIT3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; [Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]

PMID:27658547 PMID:29870746 PMID:30482226

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 3, X-linked

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

early endosome antigen 1

affects localization

Chloroquine affects the localization of EEA1 protein

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

epidermal growth factor

multiple interactions

Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]
Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]

PMID:20332299 PMID:22689575

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions
decreases expression

Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]
Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
Chloroquine results in decreased expression of EGFR protein

PMID:20056314 PMID:20332299 PMID:22457794 PMID:22689575

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4A1

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]

NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4H

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]

NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876

G

enolase 2

multiple interactions

Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein]

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

erb-b2 receptor tyrosine kinase 2

decreases expression
multiple interactions

Chloroquine results in decreased expression of ERBB2 protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]

PMID:20056314 PMID:20332299

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

decreases expression

Chloroquine results in decreased expression of ERBB3 protein

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

ERGIC and golgi 3

multiple interactions

ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]

NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813

G

eva-1 homolog A, regulator of programmed cell death

multiple interactions

Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in increased degradation of EVA1A protein]

NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011

G

fatty acid desaturase 2

decreases expression

Chloroquine results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

Fas ligand

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FASL protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 32

affects expression

Chloroquine affects the expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

fibroblast growth factor 1

multiple interactions

Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

formin 1

decreases expression

Chloroquine results in decreased expression of FMN1 mRNA

NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220

G

forkhead box P3

multiple interactions

Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 protein]

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

ferritin heavy chain 1

multiple interactions
increases expression

Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of FTH1 protein]; Chloroquine inhibits the reaction [Diquat results in decreased expression of and results in increased degradation of FTH1 protein]
Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]
Chloroquine results in increased expression of FTH1 mRNA

PMID:30551460 PMID:32937103 PMID:37951334 PMID:38128689 PMID:38326183

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

multiple interactions

Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

FUN14 domain containing 1

multiple interactions

Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein]

PMID:32001317 PMID:37156403

NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284

G

GABA type A receptor associated protein like 2

increases expression

Chloroquine results in increased expression of GABARAPL2 protein

NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628

G

galactose-3-O-sulfotransferase 1

multiple interactions

GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]

NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388

G

gap junction protein, alpha 1

multiple interactions

Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein]
Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]

PMID:8824497 PMID:22150760 PMID:28713934

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 2

decreases expression

Chloroquine results in decreased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

galactosidase, beta 1

multiple interactions

[Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein
Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]]

PMID:30025493 PMID:36792013

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glucagon-like peptide 1 receptor

multiple interactions

Chloroquine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

glutamate-ammonia ligase

decreases expression

Chloroquine results in decreased expression of GLUL protein

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

golgin A2

affects localization

Chloroquine affects the localization of GOLGA2 protein

NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279

G

glycoprotein nmb

increases expression

Chloroquine results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 182

decreases expression

Chloroquine results in decreased expression of GPR182 mRNA

NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210

G

glutamic--pyruvic transaminase

multiple interactions

Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]; Chloroquine promotes the reaction [Acetaminophen results in increased activity of GPT protein]
[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein

PMID:26498332 PMID:33271250 PMID:36482696

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 4

decreases expression
multiple interactions

Chloroquine results in decreased expression of GPX4 mRNA
Chloroquine inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of GPX4 protein]; Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of GPX4 protein]
Chloroquine inhibits the reaction [Cisplatin results in decreased expression of GPX4 protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]

PMID:23607047 PMID:34302894 PMID:36700298 PMID:38097005 PMID:38326183

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

gasdermin D

multiple interactions

Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glutathione-disulfide reductase

decreases activity
decreases expression
multiple interactions

Chloroquine results in decreased activity of GSR protein
Chloroquine results in decreased expression of GSR mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GSR mRNA]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hemoglobin subunit gamma 1

decreases expression

Chloroquine results in decreased expression of HBG1 mRNA

NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425

G

histone deacetylase 6

multiple interactions

Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]]

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

G

hexokinase 2

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

hydroxymethylbilane synthase

increases response to substance

HMBS mutant form results in increased susceptibility to Chloroquine

NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form
Chloroquine inhibits the reaction [Thymol inhibits the reaction [Ethanol results in decreased expression of HSPA8 protein]]

PMID:30821613 PMID:36535314

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

intercellular adhesion molecule 1

multiple interactions

Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon beta 1

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IFNG protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]

PMID:22341560 PMID:29594315 PMID:30482226

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 2 mRNA binding protein 3

multiple interactions

[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein

NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression

Chloroquine results in decreased expression of IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

decreases expression

Chloroquine results in decreased expression of IKBKG protein

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

interleukin 10

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL13 protein]

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 17A

multiple interactions

Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL17A protein]

PMID:22341560 PMID:36002070

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

increases expression
multiple interactions

Chloroquine results in increased expression of IL1A
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1A protein]

PMID:15139008 PMID:22341560

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
decreases expression
multiple interactions

Chloroquine results in increased expression of IL1B
Chloroquine results in decreased expression of IL1B mRNA
Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL1B protein]

PMID:15139008 PMID:21051542 PMID:22341560 PMID:26498332 PMID:29594315 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression
multiple interactions

Chloroquine results in decreased expression of IL2 mRNA; Chloroquine results in decreased expression of IL2 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein]
[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

PMID:7554381 PMID:22341560 PMID:29594315

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 3

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein]

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression
multiple interactions
decreases secretion
increases expression

Chloroquine results in decreased expression of IL6 protein
Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]]
Chloroquine results in decreased secretion of IL6 protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]]
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]
Chloroquine results in increased expression of IL6

PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 3

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]

PMID:22341560 PMID:25780039 PMID:28134560

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

integrin subunit alpha M

multiple interactions

[benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with Chloroquine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; Chloroquine inhibits the reaction [Tretinoin affects the localization of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Janus kinase 2

decreases phosphorylation

chloroquine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium

RGD

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

laminin subunit beta 1

multiple interactions

Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

lysosomal-associated membrane protein 2

multiple interactions

[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

linker for activation of T cells family, member 2

increases response to substance

LAT2 protein results in increased susceptibility to Chloroquine

NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288

G

lipocalin 2

increases expression

Chloroquine results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactate dehydrogenase A

multiple interactions

Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

low density lipoprotein receptor

multiple interactions

Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

leptin

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

increases expression

Chloroquine results in increased expression of LEPR protein

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

lymphotoxin beta

increases expression

Chloroquine results in increased expression of LTB

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

mannose-6-phosphate receptor, cation dependent

affects expression
affects localization

Chloroquine affects the expression of M6PR mRNA
Chloroquine affects the localization of M6PR protein

PMID:15712280 PMID:29940786

NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216

G

microtubule-associated protein 1 light chain 3 alpha

increases expression
multiple interactions

Chloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified form
Chloroquine inhibits the reaction [doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of MAP1LC3A protein]
Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3A protein]
Chloroquine inhibits the reaction [hydroquinone results in increased degradation of MAP1LC3A protein]

PMID:30280407 PMID:30871063 PMID:35137919 PMID:35302183 PMID:35843418

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

increases expression
decreases degradation
increases lipidation
multiple interactions
affects localization
increases cleavage

Chloroquine results in increased expression of MAP1LC3B mRNA; Chloroquine results in increased expression of MAP1LC3B protein; Chloroquine results in increased expression of MAP1LC3B protein modified form
Chloroquine results in decreased degradation of MAP1LC3B protein modified form
Chloroquine results in increased lipidation of MAP1LC3B protein
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [trichostatin A results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]
Chloroquine affects the localization of MAP1LC3B protein
Chloroquine results in increased cleavage of MAP1LC3B protein
[Ethanol co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [dibromoacetonitrile results in increased expression of and results in increased localization of MAP1LC3B protein]; Chloroquine results in increased lipidation of and results in increased localization of MAP1LC3B protein; MJN110 affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
[4-nitrochalcone co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with aumolertinib] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; [Chloroquine co-treated with Oxygen deficiency] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [dorsomorphin results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [cordycepin results in increased expression of MAP1LC3B mRNA]; Chloroquine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Chloroquine promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline affects the localization of MAP1LC3B protein]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [ABBV-744 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [ABBV-744 results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [bisphenol A results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Ethanol results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [fosbretabulin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [palmitoyl glycerol results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sepantronium results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sodium arsenite results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein; Chloroquine results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Paraquat inhibits the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]

PMID:17643062 PMID:23880069 PMID:24095927 PMID:24145604 PMID:24161432 More...

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

multiple interactions

Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Chloroquine results in increased phosphorylation of MAPK1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]

PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

Chloroquine inhibits the reaction [hydroquinone results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]
Chloroquine results in increased phosphorylation of MAPK3 protein

PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]

PMID:22341560 PMID:28134560 PMID:31648047

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microtubule-associated protein tau

affects expression
multiple interactions

Chloroquine affects the expression of MAPT mRNA; Chloroquine affects the expression of MAPT protein
Chloroquine inhibits the reaction [Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein]
Chloroquine affects the localization of and affects the degradation of MAPT protein

PMID:9690670 PMID:33124469

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

microRNA 155

multiple interactions

[Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 224

inhibits the reaction [Amiodarone decreased expression of miR224 in a human hepatoma cell line]

RGD

NCBI chr X:150,065,088...150,065,169
Ensembl chr X:150,065,088...150,065,169

G

marker of proliferation Ki-67

multiple interactions

[Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein
[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]

PMID:30025493 PMID:30482226

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 13

multiple interactions
increases expression

Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine results in increased expression of MMP13 mRNA; Chloroquine results in increased expression of MMP13 protein
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]

PMID:23331101 PMID:24273604

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

decreases expression
multiple interactions

Chloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 protein
Chloroquine inhibits the reaction [cordycepin results in decreased activity of MMP2 protein]; Chloroquine inhibits the reaction [cordycepin results in decreased expression of MMP2 mRNA]; Sirolimus inhibits the reaction [Chloroquine results in decreased expression of MMP2 protein]

PMID:24273604 PMID:34278709 PMID:36299321

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression
decreases expression

Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Oxygen deficiency inhibits the reaction [Chloroquine results in decreased expression of MMP9 mRNA]
Chloroquine results in increased expression of MMP9 mRNA
Chloroquine results in decreased expression of MMP9 mRNA; Chloroquine results in decreased expression of MMP9 protein

PMID:24145604 PMID:24273604 PMID:30551460

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrial transcription termination factor 3

multiple interactions

Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MTERF3 protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of MTERF3 protein]

NCBI chr 7:63,826,418...63,844,747
Ensembl chr 7:63,826,427...63,844,658

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation
increases expression

Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]
Chloroquine results in decreased phosphorylation of MTOR protein
Chloroquine results in increased expression of MTOR protein

PMID:25884947 PMID:27180204 PMID:31310755

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

microsomal triglyceride transfer protein

multiple interactions
increases expression

[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Chloroquine] results in increased expression of MTTP protein
Chloroquine results in increased expression of MTTP protein

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

mucin 1, cell surface associated

multiple interactions

Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

MYD88, innate immune signal transduction adaptor

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myomesin 2

increases expression

Chloroquine results in increased expression of MYOM2 mRNA

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

nucleus accumbens associated 1

multiple interactions

Chloroquine affects the reaction [NACC1 affects the susceptibility to Cisplatin]

NCBI chr19:23,468,688...23,486,528
Ensembl chr19:23,468,419...23,486,528

G

nuclear receptor coactivator 4

multiple interactions
increases expression

Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]; Chloroquine inhibits the reaction [Particulate Matter results in increased expression of NCOA4 protein]
Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
Chloroquine results in increased expression of NCOA4 mRNA; Chloroquine results in increased expression of NCOA4 protein

PMID:30551460 PMID:32937103 PMID:36482696 PMID:36700298 PMID:37951334

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

N-myc downstream regulated 1

multiple interactions

Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of NDRG1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased expression of NDRG1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the susceptibility to [fosbretabulin co-treated with Chloroquine]

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

nuclear factor kappa B subunit 1

decreases expression
multiple interactions

Chloroquine results in decreased expression of NFKB1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein]

PMID:22341560 PMID:26116531

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; Chloroquine inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]

PMID:24085292 PMID:28134560 PMID:30821613

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

Chloroquine inhibits the reaction [PPARG protein inhibits the reaction [Dexamethasone results in increased expression of NLRP3 protein]]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nucleotide-binding oligomerization domain containing 2

multiple interactions

NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nitric oxide synthase 2

multiple interactions

Chloroquine promotes the reaction [sunitinib results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

multiple interactions

[Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

natriuretic peptide C

decreases expression

Chloroquine results in decreased expression of NPPC mRNA

NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

Chloroquine binds to and results in decreased activity of NQO2 protein

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

Chloroquine results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions

Chloroquine binds to and results in increased activity of NR4A2 protein

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

occludin

increases expression

Chloroquine results in increased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

optineurin

multiple interactions

Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]

NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251

G

oxidative stress induced growth inhibitor 1

decreases expression

Chloroquine results in decreased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein]
Chloroquine results in increased cleavage of PARP1 protein
[Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased activity of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]

PMID:27658547 PMID:28906492 PMID:29111403 PMID:30025493 PMID:30338810 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

Chloroquine inhibits the reaction [Imiquimod results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

PTEN induced kinase 1

multiple interactions

Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PINK1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

perilipin 3

multiple interactions

Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA]; Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 protein]

NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of PMAIP1 protein]

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

proopiomelanocortin

multiple interactions

Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Chloroquine inhibits the reaction [PPARG protein inhibits the reaction [Dexamethasone results in increased expression of NLRP3 protein]]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

Chloroquine inhibits the reaction [hydroquinone results in increased expression of PPP2CA protein]

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

palmitoyl-protein thioesterase 1

multiple interactions

Chloroquine analog binds to and results in decreased activity of PPT1 protein; Chloroquine binds to and results in decreased activity of PPT1 protein

NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048

G

protein kinase D2

multiple interactions

Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PRKN protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]]
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]

PMID:33271250 PMID:35104487

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prolactin receptor

decreases expression

Chloroquine results in decreased expression of PRLR mRNA

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

phosphatase and tensin homolog

increases expression

Chloroquine results in increased expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Chloroquine inhibits the reaction [bisphenol A results in increased expression of PTGS2 protein]; Chloroquine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]

PMID:24145604 PMID:36700298 PMID:38326183

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

recombination signal binding protein for immunoglobulin kappa J region

increases expression

Chloroquine results in increased expression of RBPJ protein

NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
increases activity

Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased activity of RELA protein]
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of RELA protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of RELA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]
Chloroquine results in decreased expression of RELA protein

PMID:15139008 PMID:24990399 PMID:26116531 PMID:28134560

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

Ras homolog, mTORC1 binding

multiple interactions

Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]

NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160

G

ras homolog family member B

increases expression

Chloroquine results in increased expression of RHOB protein

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions
increases expression

Chloroquine results in decreased phosphorylation of RPS6KB1 protein
Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]
Chloroquine results in increased expression of RPS6KB1 protein modified form

PMID:22689575 PMID:25884947 PMID:31310755

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 2

multiple interactions

Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

scavenger receptor class B, member 1

decreases expression
multiple interactions

Chloroquine results in decreased expression of SCARB1 mRNA
[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]

PMID:19393257 PMID:20404351

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

saccharopine dehydrogenase (putative)

decreases expression

Chloroquine results in decreased expression of SCCPDH mRNA

NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222

G

stearoyl-CoA desaturase

decreases expression

Chloroquine results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

SUMO specific peptidase 6

multiple interactions

[Lipopolysaccharides co-treated with Chloroquine] results in increased expression of SENP6 protein

NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170

G

serpin family A member 3N

affects localization

Chloroquine affects the localization of SERPINA3 protein

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family E member 1

multiple interactions

Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sirtuin 3

increases stability
multiple interactions

Chloroquine results in increased stability of SIRT3 mRNA
Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 mRNA]; Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 protein]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 12 member 1

decreases expression

Chloroquine results in decreased expression of SLC12A1 protein

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 14 member 2

multiple interactions

Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein]

NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968

G

solute carrier family 19 member 3

multiple interactions

Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337

G

solute carrier family 22 member 1

multiple interactions

Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions

Chloroquine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 2 member 4

affects localization
multiple interactions

Chloroquine affects the localization of SLC2A4 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein; gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 7 member 11

multiple interactions

Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SLC7A11 protein]
Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of SLC7A11 protein]

PMID:34302894 PMID:36700298

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

snail family transcriptional repressor 1

multiple interactions

Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 1

multiple interactions
decreases expression

Quercetin inhibits the reaction [Chloroquine results in decreased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sortilin 1

decreases expression
multiple interactions

Chloroquine results in decreased expression of SORT1 protein
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]

PMID:25805502 PMID:30950489

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

Sp1 transcription factor

multiple interactions

Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sequestosome 1

multiple interactions
increases expression

[Chloroquine co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein; Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[venetoclax co-treated with WEHI-539] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ABBV-744 results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [decabromobiphenyl ether results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [fosbretabulin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [hydroquinone results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [SC-66 compound results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [sepantronium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [lead acetate results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]]
[bisphenol A co-treated with Chloroquine] results in increased expression of SQSTM1 protein; Chloroquine affects the reaction [SQSTM1 protein affects the susceptibility to methylmercuric chloride]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Sunitinib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]

PMID:21858812 PMID:22927544 PMID:23651616 PMID:24262987 PMID:24751611 More...

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

small RNA binding exonuclease protection factor La

multiple interactions

Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein]

NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203

G

steroidogenic acute regulatory protein

decreases expression

Chloroquine results in decreased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

stanniocalcin 2

decreases expression

Chloroquine results in decreased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

serine/threonine kinase receptor associated protein

decreases expression

Chloroquine results in decreased expression of STRAP mRNA

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

synaptophysin

multiple interactions

Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP]

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

TAR DNA binding protein

increases expression
multiple interactions

Chloroquine results in increased expression of TARDBP protein
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]

NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055

G

tet methylcytosine dioxygenase 2

multiple interactions

Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 protein]

NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534

G

trans-golgi network protein 2

affects localization

Chloroquine affects the localization of TGOLN2 protein

NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164

G

thyroid hormone receptor alpha

multiple interactions

Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

TIR domain containing adaptor molecule 2

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA]

NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein]
Chloroquine results in decreased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]

PMID:22341560 PMID:30551460

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP2 protein]

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

toll-like receptor 3

multiple interactions

Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

toll-like receptor 4

multiple interactions

Chloroquine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

toll-like receptor 7

decreases activity

Chloroquine results in decreased activity of TLR7 protein

NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754

G

toll-like receptor 8

decreases activity

Chloroquine results in decreased activity of TLR8 protein

NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549

G

toll-like receptor 9

decreases activity
decreases expression
multiple interactions
increases expression

Chloroquine results in decreased activity of TLR9 protein
Chloroquine results in decreased expression of TLR9 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein]
Chloroquine results in increased expression of TLR9 mRNA
Chloroquine inhibits the reaction [CpG ODN 2006 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [CpG ODN 2395 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TLR9 mRNA]; Oxygen deficiency inhibits the reaction [Chloroquine results in increased expression of TLR9 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]

PMID:21398612 PMID:22595112 PMID:24273604 PMID:24990399

NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796

G

transmembrane 7 superfamily member 2

decreases expression

Chloroquine results in decreased expression of TM7SF2 mRNA

NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270

G

tumor necrosis factor

decreases expression
multiple interactions
decreases secretion
increases expression

Chloroquine results in decreased expression of TNF protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
[Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [hydroquinone results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]
Chloroquine results in decreased secretion of TNF protein
Chloroquine results in increased expression of TNF
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]

PMID:8244452 PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 10b

increases expression

Chloroquine results in increased expression of TNFRSF10A protein

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 11A

multiple interactions

Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A protein]

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 1A

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1B protein]

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

translocase of outer mitochondrial membrane 20

multiple interactions

Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein]

NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198

G

tumor protein p53

increases activity
multiple interactions

Chloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 protein
Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]

PMID:11589424 PMID:12082016 PMID:18089834 PMID:22927544

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tribbles pseudokinase 3

increases expression
multiple interactions

Chloroquine results in increased expression of TRIB3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

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tripartite motif containing 63

affects expression

Chloroquine affects the expression of TRIM63 mRNA

NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322

G

transient receptor potential cation channel, subfamily C, member 1

multiple interactions

Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein]

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

ubiquitin C

increases expression

Chloroquine results in increased expression of UBC mRNA

NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925

G

ubiquitin specific peptidase 2

multiple interactions
increases expression

Chloroquine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of USP2 mRNA]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Chloroquine results in increased expression of USP2 mRNA]

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

ubiquitin specific peptidase 25

increases expression
multiple interactions

Chloroquine results in increased expression of USP25 mRNA; Chloroquine results in increased expression of USP25 protein
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Chloroquine] results in increased expression of USP25 protein; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP25 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]

NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348

G

ubiquitin specific peptidase 28

multiple interactions
increases expression

Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP28 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP28 mRNA]

NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229

G

ubiquitin specific peptidase 7

increases expression
multiple interactions

Chloroquine results in increased expression of USP7 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP7 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP7 mRNA]

NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355

G

ubiquitin specific peptidase 8

multiple interactions

[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]

NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666

G

valosin-containing protein

multiple interactions

Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

visinin-like 1

decreases expression

Chloroquine results in decreased expression of VSNL1 mRNA

NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479

G

X-C motif chemokine ligand 1

multiple interactions

Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of XCL1 protein]

NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329

G

exportin 1

multiple interactions

Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein]

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

multiple interactions

Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein]

NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273

G

zinc finger protein 36

multiple interactions

Chloroquine inhibits the reaction [hydroquinone results in decreased expression of ZFP36 protein]

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

ciprofloxacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

decreases expression

Ciprofloxacin results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression

Ciprofloxacin results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases export
multiple interactions
increases expression

ABCC4 protein results in increased export of Ciprofloxacin
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin
Ciprofloxacin results in increased expression of ABCC4 mRNA; Ciprofloxacin results in increased expression of ABCC4 protein
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin; Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]

PMID:19307362 PMID:22162766

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

increases expression

Ciprofloxacin results in increased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

AKT serine/threonine kinase 1

increases phosphorylation

Ciprofloxacin results in increased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Ciprofloxacin results in increased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases localization
increases expression

BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]
Ciprofloxacin results in increased expression of BAX protein

PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]

PMID:11832715 PMID:12063570

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity

Ciprofloxacin results in increased cleavage of and results in increased activity of CASP3 protein
Ciprofloxacin results in increased activity of CASP3 protein

PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 PMID:30273099

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

Ciprofloxacin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Ciprofloxacin results in increased activity of CASP9 protein

PMID:11875713 PMID:30273099

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
multiple interactions

Ciprofloxacin results in decreased activity of CAT protein
Quercetin inhibits the reaction [Ciprofloxacin results in decreased activity of CAT protein]

PMID:25902267 PMID:25929518

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

Ciprofloxacin results in increased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

cyclin B1

decreases expression
increases expression

Ciprofloxacin results in decreased expression of CCNB1 protein
Ciprofloxacin results in increased expression of CCNB1 mRNA; Ciprofloxacin results in increased expression of CCNB1 protein

PMID:10741713 PMID:18512786

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin E1

decreases expression

Ciprofloxacin results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

CD44 molecule

increases expression

Ciprofloxacin results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cyclin-dependent kinase 1

increases expression

Ciprofloxacin results in increased expression of CDK1 mRNA; Ciprofloxacin results in increased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases phosphorylation

Ciprofloxacin results in decreased phosphorylation of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

decreases expression

Ciprofloxacin results in decreased expression of CDKN1A; Ciprofloxacin results in decreased expression of CDKN1A protein

PMID:10741713 PMID:12063570 PMID:12632069

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein delta

multiple interactions

Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

checkpoint kinase 1

increases expression

Ciprofloxacin results in increased expression of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

colony stimulating factor 2

increases expression

Ciprofloxacin results in increased expression of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine ligand 2

decreases expression

Ciprofloxacin results in decreased expression of CXCL2 protein

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome c, somatic

increases secretion

Ciprofloxacin results in increased secretion of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

[Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]

PMID:11145498 PMID:11151749 PMID:15592331 PMID:18816299

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

Ciprofloxacin results in decreased expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Ciprofloxacin results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression

Ciprofloxacin results in decreased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

dihydroorotate dehydrogenase

multiple interactions
decreases activity

Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
Ciprofloxacin results in decreased activity of DHODH protein

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

fibroblast growth factor 19

decreases expression

Ciprofloxacin results in decreased expression of FGF15 mRNA

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

glucose-6-phosphate dehydrogenase

increases response to substance

G6PD protein mutant form results in increased susceptibility to Ciprofloxacin

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glutamic-oxaloacetic transaminase 1

increases activity

Ciprofloxacin results in increased activity of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]
Ciprofloxacin results in increased activity of GPT protein

PMID:29679711 PMID:30273099

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interferon gamma

multiple interactions
decreases expression

Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in increased expression of IFNG mRNA; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]
Ciprofloxacin results in decreased expression of IFNG protein

PMID:16006447 PMID:16968468 PMID:18337667 PMID:19401694

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]

PMID:16939481 PMID:19401694

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions

Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Ciprofloxacin results in decreased expression of IL1B protein

PMID:9267955 PMID:11052920 PMID:12428247 PMID:16148020 PMID:18197910 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 3

increases expression

Ciprofloxacin results in increased expression of IL3 mRNA; Ciprofloxacin results in increased expression of IL3 protein

NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

decreases expression

Ciprofloxacin results in decreased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]

PMID:9267955 PMID:11052920 PMID:19401694

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

potassium voltage-gated channel subfamily H member 2

affects binding

Ciprofloxacin binds to KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lipocalin 2

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

mitogen activated protein kinase 1

increases phosphorylation

Ciprofloxacin results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Ciprofloxacin results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myoglobin

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

Ciprofloxacin results in increased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

microRNA 133b

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA

NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217

G

microRNA 206

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA

NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332

G

melanocyte inducing transcription factor

decreases expression

Ciprofloxacin results in decreased expression of MITF protein

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

matrix metallopeptidase 1

multiple interactions
increases expression

Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Ciprofloxacin results in increased expression of MMP1 mRNA

PMID:12428247 PMID:16148020

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

multiple interactions
decreases expression

Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Ciprofloxacin results in decreased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

increases expression
increases activity

Ciprofloxacin results in increased expression of MMP2 mRNA
Ciprofloxacin results in increased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions
increases expression

Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

increases activity
increases expression

Ciprofloxacin results in increased activity of MMP9 protein
Ciprofloxacin results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

Ciprofloxacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

Nanog homeobox

increases expression

Ciprofloxacin results in increased expression of NANOG protein

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

nucleotide-binding oligomerization domain containing 2

decreases response to substance

NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin

NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Ciprofloxacin results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

poly (ADP-ribose) polymerase 1

increases cleavage

Ciprofloxacin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphogluconate dehydrogenase

decreases activity

Ciprofloxacin results in decreased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

polo-like kinase 1

increases expression

Ciprofloxacin results in increased expression of PLK1 protein

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

paraoxonase 1

decreases activity

Ciprofloxacin results in decreased activity of PON1 protein

PMID:16880604 PMID:31581362

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

POU class 5 homeobox 1

increases expression

Ciprofloxacin results in increased expression of POU5F1 protein

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

prominin 1

increases expression

Ciprofloxacin results in increased expression of PROM1 protein

NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527

G

RT1 class Ia, locus A2

affects expression

Ciprofloxacin affects the expression of HLA-E mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class II, locus Db1

affects expression

Ciprofloxacin affects the expression of HLA-DRB1 mRNA

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

RT1 class Ib, locus M3, gene 1

affects expression

Ciprofloxacin affects the expression of HLA-G mRNA

NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117

G

solute carrier family 2 member 1

affects localization
decreases expression

Ciprofloxacin affects the localization of SLC2A1 mRNA
Ciprofloxacin results in decreased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

SLC51 subunit beta

decreases expression

Ciprofloxacin results in decreased expression of SLC51B mRNA

NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145

G

solute carrier organic anion transporter family member 1B2

increases expression

Ciprofloxacin results in increased expression of SLCO1B2 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

snail family transcriptional repressor 1

decreases expression

Ciprofloxacin results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

Ciprofloxacin results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

SRY-box transcription factor 2

decreases expression

Ciprofloxacin results in decreased expression of SOX2 protein

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

transforming growth factor, beta 1

increases expression
multiple interactions

Ciprofloxacin results in increased expression of TGFB1 mRNA
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA

PMID:18337667 PMID:19371339

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions
decreases expression

Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; [irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]
Ciprofloxacin results in decreased expression of TNF protein

PMID:9267955 PMID:11052920 PMID:16939481 PMID:16968468 PMID:18197910 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase I

multiple interactions

[Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II alpha

affects binding
multiple interactions

Ciprofloxacin binds to TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

xin actin-binding repeat containing 1

multiple interactions

[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA

NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349

Desethylchloroquine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily c, polypeptide 79

multiple interactions

[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]

PMID:12756207 PMID:12967198

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases activity

[CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
desethylchloroquine results in decreased activity of CYP2D6 protein

PMID:11124226 PMID:12756207

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity

[CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
desethylchloroquine results in decreased activity of CYP3A4 protein

PMID:11124226 PMID:12756207

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

glafenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Glafenine results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

arylacetamide deacetylase

decreases expression

Glafenine results in decreased expression of AADAC mRNA

NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734

G

adipogenesis associated, Mth938 domain containing

decreases expression

Glafenine results in decreased expression of AAMDC mRNA

NCBI chr 1:151,861,990...151,893,621
Ensembl chr 1:151,845,255...151,892,398

G

4-aminobutyrate aminotransferase

decreases expression

Glafenine results in decreased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

increases expression

Glafenine results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

decreases expression

Glafenine results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

decreases expression

Glafenine results in decreased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

decreases expression

Glafenine results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily D member 3

decreases expression

Glafenine results in decreased expression of ABCD3 mRNA

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ATP binding cassette subfamily G member 5

decreases expression

Glafenine results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

abhydrolase domain containing 1

decreases expression

Glafenine results in decreased expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514

G

abhydrolase domain containing 14b

decreases expression

Glafenine results in decreased expression of ABHD14B mRNA

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

abhydrolase domain containing 2, acylglycerol lipase

increases expression

Glafenine results in increased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

abhydrolase domain containing 6, acylglycerol lipase

decreases expression

Glafenine results in decreased expression of ABHD6 mRNA

NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985

G

abl-interactor 1

decreases expression

Glafenine results in decreased expression of ABI1 mRNA

NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792

G

abraxas 2, BRISC complex subunit

decreases expression

Glafenine results in decreased expression of ABRAXAS2 mRNA

NCBI chr 1:187,647,078...187,672,660
Ensembl chr 1:187,647,067...187,672,655

G

ankyrin repeat and BTB domain containing 1

decreases expression

Glafenine results in decreased expression of ABTB1 mRNA

NCBI chr 4:121,299,302...121,305,667
Ensembl chr 4:121,299,304...121,305,620

G

ankyrin repeat and BTB domain containing 2

decreases expression

Glafenine results in decreased expression of ABTB2 mRNA

NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548

G

ankyrin repeat and BTB domain containing 3

decreases expression

Glafenine results in decreased expression of ABTB3 mRNA

NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834

G

acetyl-CoA acyltransferase 1A

decreases expression

Glafenine results in decreased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA carboxylase alpha

increases expression

Glafenine results in increased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase family, member 10

decreases expression

Glafenine results in decreased expression of ACAD10 mRNA

NCBI chr12:34,901,211...34,943,973
Ensembl chr12:34,901,219...34,982,521

G

acyl-CoA dehydrogenase family, member 11

decreases expression

Glafenine results in decreased expression of ACAD11 mRNA

NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560

G

acyl-CoA dehydrogenase family, member 9

decreases expression

Glafenine results in decreased expression of ACAD9 mRNA

NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547

G

acyl-CoA dehydrogenase medium chain

decreases expression

Glafenine results in decreased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

decreases expression

Glafenine results in decreased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA binding domain containing 5

decreases expression

Glafenine results in decreased expression of ACBD5 mRNA

NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215

G

alkaline ceramidase 2

increases expression

Glafenine results in increased expression of ACER2 mRNA

NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614

G

atypical chemokine receptor 3

increases expression

Glafenine results in increased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

acyl-CoA thioesterase 12

decreases expression

Glafenine results in decreased expression of ACOT12 mRNA

NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536

G

acyl-CoA thioesterase 2

decreases expression

Glafenine results in decreased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 4

decreases expression

Glafenine results in decreased expression of ACOT4 mRNA

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA oxidase 1

decreases expression

Glafenine results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Glafenine results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

acyl-CoA synthetase medium-chain family member 2

decreases expression

Glafenine results in decreased expression of ACSM2A mRNA

NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116

G

acyl-CoA synthetase short-chain family member 2

decreases expression

Glafenine results in decreased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin, gamma 1

increases expression

Glafenine results in increased expression of ACTG1 mRNA

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

aarF domain containing kinase 5

decreases expression

Glafenine results in decreased expression of ADCK5 mRNA

NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Glafenine results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase, iron containing, 1

decreases expression

Glafenine results in decreased expression of ADHFE1 mRNA

NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517

G

adiponectin receptor 2

decreases expression

Glafenine results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adenosine kinase

decreases expression

Glafenine results in decreased expression of ADK mRNA

NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510

G

adenylosuccinate synthase 1

decreases expression

Glafenine results in decreased expression of ADSS1 mRNA

NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998

G

adenylosuccinate synthase 2

decreases expression

Glafenine results in decreased expression of ADSS2 mRNA

NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604

G

androgen-dependent TFPI-regulating protein

decreases expression

Glafenine results in decreased expression of ADTRP mRNA

NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826

G

afamin

decreases expression

Glafenine results in decreased expression of AFM mRNA

NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870

G

arylformamidase

decreases expression

Glafenine results in decreased expression of AFMID mRNA

NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718

G

agmatinase

decreases expression

Glafenine results in decreased expression of AGMAT mRNA

NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276

G

alkylglycerol monooxygenase

decreases expression

Glafenine results in decreased expression of AGMO mRNA

NCBI chr 6:53,986,236...54,317,838
Ensembl chr 6:53,986,292...54,317,623

G

adenosylhomocysteinase

decreases expression

Glafenine results in decreased expression of AHCY mRNA

NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

increases expression

Glafenine results in increased expression of AIMP2 mRNA

NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769

G

adenylate kinase 3

decreases expression

Glafenine results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

aldo-keto reductase family 1 member A1

increases expression

Glafenine results in increased expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1, member C1

decreases expression

Glafenine results in decreased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1 member C3-like 1

decreases expression

Glafenine results in decreased expression of AKR1C3L1 mRNA

NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488

G

aldo-keto reductase family 1, member E2

decreases expression

Glafenine results in decreased expression of AKR1E2 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

G

aldo-keto reductase family 7, member A2

decreases expression

Glafenine results in decreased expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldo-keto reductase family 7 member A3

decreases expression

Glafenine results in decreased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

5'-aminolevulinate synthase 1

decreases expression

Glafenine results in decreased expression of ALAS1 mRNA

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Glafenine results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member L1

decreases expression

Glafenine results in decreased expression of ALDH1L1 mRNA

NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465

G

aldehyde dehydrogenase 2 family member

decreases expression

Glafenine results in decreased expression of ALDH2 mRNA

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A2

decreases expression

Glafenine results in decreased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

Glafenine results in decreased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

aldehyde dehydrogenase 5 family, member A1

decreases expression

Glafenine results in decreased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

Glafenine results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 9 family, member A1

decreases expression

Glafenine results in decreased expression of ALDH9A1 mRNA

NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568

G

aldolase, fructose-bisphosphate A

increases expression

Glafenine results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

ALG12, alpha-1,6-mannosyltransferase

increases expression

Glafenine results in increased expression of ALG12 mRNA

NCBI chr 7:119,895,112...119,909,488
Ensembl chr 7:119,895,120...119,909,458

G

ALG2, alpha-1,3/1,6-mannosyltransferase

increases expression

Glafenine results in increased expression of ALG2 mRNA

NCBI chr 5:61,768,738...61,773,297
Ensembl chr 5:61,768,740...61,773,297

G

ALG3, alpha-1,3- mannosyltransferase

increases expression

Glafenine results in increased expression of ALG3 mRNA

NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912

G

alpha-methylacyl-CoA racemase

decreases expression

Glafenine results in decreased expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

adhesion molecule with Ig like domain 3

increases expression

Glafenine results in increased expression of AMIGO3 mRNA

NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555

G

amylase alpha 1

decreases expression

Glafenine results in decreased expression of AMY1A mRNA

NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816

G

angiogenin

decreases expression

Glafenine results in decreased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

angiopoietin-like 3

decreases expression

Glafenine results in decreased expression of ANGPTL3 mRNA

NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957

G

ankyrin repeat domain 24

increases expression

Glafenine results in increased expression of ANKRD24 mRNA

NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142

G

ankyrin repeat domain 46

decreases expression

Glafenine results in decreased expression of ANKRD46 mRNA

NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132

G

ankyrin repeat and sterile alpha motif domain containing 4B

decreases expression

Glafenine results in decreased expression of ANKS4B mRNA

NCBI chr 1:174,534,195...174,557,798
Ensembl chr 1:174,547,473...174,557,797

G

ANTXR cell adhesion molecule 2

decreases expression

Glafenine results in decreased expression of ANTXR2 mRNA

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

G

annexin A4

decreases expression

Glafenine results in decreased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

antisense paternally expressed gene 3

increases expression

Glafenine results in increased expression of APEG3 mRNA

NCBI chr 1:67,121,402...67,122,333
Ensembl chr 1:67,121,900...67,122,181
Ensembl chr 1:67,121,900...67,122,181

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases expression

Glafenine results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

adipocyte plasma membrane associated protein

decreases expression

Glafenine results in decreased expression of APMAP mRNA

NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341

G

apolipoprotein A2

decreases expression

Glafenine results in decreased expression of APOA2 mRNA

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

Apol9a-Apol7a readthrough

decreases expression

Glafenine results in decreased expression of APOL7B mRNA

NCBI chr 7:109,118,559...109,149,798
Ensembl chr 7:109,131,064...109,147,649

G

amyloid beta precursor protein binding protein 2

decreases expression

Glafenine results in decreased expression of APPBP2 mRNA

NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835

G

adenine phosphoribosyl transferase

increases expression

Glafenine results in increased expression of APRT mRNA

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

ARF GTPase 4

increases expression

Glafenine results in increased expression of ARF4 mRNA

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

ARF GTPase activating protein 3

increases expression

Glafenine results in increased expression of ARFGAP3 mRNA

NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208

G

ARF guanine nucleotide exchange factor 1

decreases expression

Glafenine results in decreased expression of ARFGEF1 mRNA

NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326

G

ARF interacting protein 2

increases expression

Glafenine results in increased expression of ARFIP2 mRNA

NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336

G

Rho GTPase activating protein 1

increases expression

Glafenine results in increased expression of ARHGAP1 mRNA

NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396

G

Rho GTPase activating protein 18

decreases expression

Glafenine results in decreased expression of ARHGAP18 mRNA

NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256

G

Rho GTPase activating protein 24

decreases expression

Glafenine results in decreased expression of ARHGAP24 mRNA

NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823

G

ARL6 interacting reticulophagy regulator 1

decreases expression

Glafenine results in decreased expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

ARF like GTPase 6 interacting protein 4

increases expression

Glafenine results in increased expression of ARL6IP4 mRNA

NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799

G

armadillo repeat containing 9

increases expression

Glafenine results in increased expression of ARMC9 mRNA

NCBI chr 9:86,802,791...86,928,611
Ensembl chr 9:86,802,868...86,928,860

G

armadillo repeat containing, X-linked 3

increases expression

Glafenine results in increased expression of ARMCX3 mRNA

NCBI chr X:97,937,115...97,942,098
Ensembl chr X:97,936,999...97,942,098

G

actin related protein 2/3 complex, subunit 1B

increases expression

Glafenine results in increased expression of ARPC1B mRNA

NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747

G

actin related protein 2/3 complex, subunit 5-like

increases expression

Glafenine results in increased expression of ARPC5L mRNA

NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538

G

argininosuccinate lyase

decreases expression

Glafenine results in decreased expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

argininosuccinate synthase 1

decreases expression

Glafenine results in decreased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

activating transcription factor 4

increases expression

Glafenine results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

autophagy related 13

increases expression

Glafenine results in increased expression of ATG13 mRNA

NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043

G

autophagy related 16-like 2

increases expression

Glafenine results in increased expression of ATG16L2 mRNA

NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420

G

autophagy related 2B

decreases expression

Glafenine results in decreased expression of ATG2B mRNA

NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015

G

atlastin GTPase 2

decreases expression

Glafenine results in decreased expression of ATL2 mRNA

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

atos homolog A

decreases expression

Glafenine results in decreased expression of ATOSA mRNA

NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549

G

ATPase phospholipid transporting 11A

decreases expression

Glafenine results in decreased expression of ATP11A mRNA

NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640

G

ATPase phospholipid transporting 11C

decreases expression

Glafenine results in decreased expression of ATP11C mRNA

NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204

G

ATPase Na+/K+ transporting subunit beta 1

decreases expression

Glafenine results in decreased expression of ATP1B1 mRNA

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression

Glafenine results in increased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATP synthase membrane subunit c locus 1

increases expression

Glafenine results in increased expression of ATP5MC1 mRNA

NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124

G

attractin

decreases expression

Glafenine results in decreased expression of ATRN mRNA

NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322

G

ataxin 2

decreases expression

Glafenine results in decreased expression of ATXN2 mRNA

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

aurora kinase A interacting protein 1

increases expression

Glafenine results in increased expression of AURKAIP1 mRNA

NCBI chr 5:166,435,177...166,436,888
Ensembl chr 5:166,417,508...166,436,882

G

beta-2 microglobulin

decreases expression

Glafenine results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

beta-1,4-galactosyltransferase 1

increases expression

Glafenine results in increased expression of B4GALT1 mRNA

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

beta-1,4-glucuronyltransferase 1

decreases expression

Glafenine results in decreased expression of B4GAT1 mRNA

NCBI chr 1:202,343,268...202,345,490
Ensembl chr 1:202,343,240...202,346,065

G

bile acid CoA:amino acid N-acyltransferase

decreases expression

Glafenine results in decreased expression of BAAT mRNA

NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685

G

BRISC and BRCA1 A complex member 1

increases expression

Glafenine results in increased expression of BABAM1 mRNA

NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923

G

brain abundant, membrane attached signal protein 1

increases expression

Glafenine results in increased expression of BASP1 mRNA

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

bublin coiled coil protein

increases expression

Glafenine results in increased expression of BBLN mRNA

NCBI chr 3:15,674,577...15,677,322
Ensembl chr 3:15,674,580...15,677,374

G

gamma-butyrobetaine hydroxylase 1

decreases expression

Glafenine results in decreased expression of BBOX1 mRNA

NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458

G

Bardet-Biedl syndrome 2

decreases expression

Glafenine results in decreased expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

BCL3, transcription coactivator

increases expression

Glafenine results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

Bet1 golgi vesicular membrane trafficking protein-like

increases expression

Glafenine results in increased expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

basic helix-loop-helix family, member e40

increases expression

Glafenine results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

betaine-homocysteine S-methyltransferase

decreases expression

Glafenine results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

betaine-homocysteine S-methyltransferase 2

decreases expression

Glafenine results in decreased expression of BHMT2 mRNA

NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475

G

biogenesis of lysosomal organelles complex 1 subunit 5

decreases expression

Glafenine results in decreased expression of BLOC1S5 mRNA

NCBI chr17:26,171,965...26,197,276
Ensembl chr17:26,172,018...26,197,251

G

biliverdin reductase B

decreases expression

Glafenine results in decreased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

BCL2 interacting protein 1

increases expression

Glafenine results in increased expression of BNIP1 mRNA

NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157

G

BCL2 interacting protein 3 like

decreases expression

Glafenine results in decreased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

bolA family member 2, pseudogene 4

increases expression

Glafenine results in increased expression of BOLA2-PS4 mRNA

NCBI chr 3:153,272,435...153,272,781

G

bolA family member 3

increases expression

Glafenine results in increased expression of BOLA3 mRNA

NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797

G

BOP1 ribosomal biogenesis factor

increases expression

Glafenine results in increased expression of BOP1 mRNA

NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931

G

BLOC-1 related complex subunit 7

increases expression

Glafenine results in increased expression of BORCS7 mRNA

NCBI chr 1:245,564,347...245,578,182
Ensembl chr 1:245,564,369...245,579,343

G

biphenyl hydrolase like

decreases expression

Glafenine results in decreased expression of BPHL mRNA

NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288

G

bromodomain containing 3

decreases expression

Glafenine results in decreased expression of BRD3 mRNA

NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577

G

biogenesis of ribosomes BRX1

increases expression

Glafenine results in increased expression of BRIX1 mRNA

NCBI chr 2:59,450,608...59,461,486
Ensembl chr 2:59,450,614...59,461,495

G

BTB domain containing 1

decreases expression

Glafenine results in decreased expression of BTBD1 mRNA

NCBI chr 1:135,734,549...135,773,067
Ensembl chr 1:135,734,589...135,771,981

G

BTB domain containing 6

decreases expression

Glafenine results in decreased expression of BTBD6 mRNA

NCBI chr 6:132,058,094...132,060,603
Ensembl chr 6:132,058,096...132,060,587

G

BTG anti-proliferation factor 2

increases expression

Glafenine results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

increases expression

Glafenine results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

bystin-like

increases expression

Glafenine results in increased expression of BYSL mRNA

NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339

G

similar to human chromosome 17 open reading frame 58

increases expression

Glafenine results in increased expression of C10H17ORF58 mRNA

NCBI chr10:91,972,938...91,977,606
Ensembl chr10:91,972,410...91,977,602

G

similar to human chromosome 14 open reading frame 119

increases expression

Glafenine results in increased expression of C15H14ORF119 mRNA

NCBI chr15:28,146,368...28,151,422
Ensembl chr15:28,146,333...28,155,180

G

similar to human chromosome 18 open reading frame 32

increases expression

Glafenine results in increased expression of C18H18ORF32 mRNA

NCBI chr18:68,586,278...68,594,851
Ensembl chr18:68,586,211...68,596,787

G

complement C1q binding protein

increases expression

Glafenine results in increased expression of C1QBP mRNA

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

complement component 4 binding protein, beta

increases expression

Glafenine results in increased expression of C4BPB mRNA

NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817

G

complement C5

increases expression

Glafenine results in increased expression of C5 mRNA

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

similar to human chromosome 1 open reading frame 122

increases expression

Glafenine results in increased expression of C5H1ORF122 mRNA

NCBI chr 5:137,109,093...137,110,130
Ensembl chr 5:137,108,633...137,110,929

G

similar to human chromosome 11 open reading frame 54

decreases expression

Glafenine results in decreased expression of C8H11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

complement C9

increases expression

Glafenine results in increased expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

increases expression

Glafenine results in increased expression of CAD mRNA

NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861

G

calmodulin 1

increases expression

Glafenine results in increased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calreticulin

increases expression

Glafenine results in increased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

increases expression

Glafenine results in increased expression of CALU mRNA

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

cell cycle associated protein 1

decreases expression

Glafenine results in decreased expression of CAPRIN1 mRNA

NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502

G

carbonic anhydrase 14

decreases expression

Glafenine results in decreased expression of CAR14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

carbonic anhydrase 3

decreases expression

Glafenine results in decreased expression of CAR3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

carbonic anhydrase 5A

decreases expression

Glafenine results in decreased expression of CAR5A mRNA

NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906

G

carbonic anhydrase 8

increases expression

Glafenine results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

cysteinyl-tRNA synthetase 1

increases expression

Glafenine results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

cysteinyl-tRNA synthetase 2, mitochondrial

decreases expression

Glafenine results in decreased expression of CARS2 mRNA

NCBI chr16:77,945,468...77,987,163
Ensembl chr16:77,950,008...77,987,772

G

catalase

decreases expression

Glafenine results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 2

increases expression

Glafenine results in increased expression of CAV2 mRNA

NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244

G

carbonyl reductase 4

decreases expression

Glafenine results in decreased expression of CBR4 mRNA

NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712

G

coiled-coil domain containing 125

increases expression

Glafenine results in increased expression of CCDC125 mRNA

NCBI chr 2:31,809,120...31,835,538
Ensembl chr 2:31,809,228...31,850,152

G

coiled-coil domain containing 134

increases expression

Glafenine results in increased expression of CCDC134 mRNA

NCBI chr 7:113,644,557...113,659,050
Ensembl chr 7:113,644,639...113,659,050

G

coiled-coil domain containing 167

increases expression

Glafenine results in increased expression of CCDC167 mRNA

NCBI chr20:7,763,927...7,782,090
Ensembl chr20:7,751,782...7,781,613

G

coiled-coil domain containing 28A

decreases expression

Glafenine results in decreased expression of CCDC28A mRNA

NCBI chr 1:12,857,668...12,872,944
Ensembl chr 1:12,857,666...12,873,003

G

coiled-coil domain containing 86

increases expression

Glafenine results in increased expression of CCDC86 mRNA

NCBI chr 1:207,590,167...207,596,547
Ensembl chr 1:207,590,168...207,596,544

G

cyclin G2

decreases expression

Glafenine results in decreased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cyclin I

decreases expression

Glafenine results in decreased expression of CCNI mRNA

NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510

G

Cd2 (cytoplasmic tail) binding protein 2

increases expression

Glafenine results in increased expression of CD2BP2 mRNA

NCBI chr 1:181,809,399...181,815,269
Ensembl chr 1:181,809,406...181,813,448

G

Cd48 molecule

increases expression

Glafenine results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD59b molecule

decreases expression

Glafenine results in decreased expression of CD59 mRNA

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

cytidine and dCMP deaminase domain containing 1

decreases expression

Glafenine results in decreased expression of CDADC1 mRNA

NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576

G

CDC42 small effector 1

increases expression

Glafenine results in increased expression of CDC42SE1 mRNA

NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028

G

cell division cycle 5-like

decreases expression

Glafenine results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cadherin 2

decreases expression

Glafenine results in decreased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cell death-inducing p53 target 1

decreases expression

Glafenine results in decreased expression of CDIP1 mRNA

NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980

G

cyclin-dependent kinase 2 associated protein 1

increases expression

Glafenine results in increased expression of CDK2AP1 mRNA

NCBI chr12:32,249,752...32,258,483
Ensembl chr12:32,249,747...32,258,479

G

cyclin-dependent kinase 2 associated protein 2

increases expression

Glafenine results in increased expression of CDK2AP2 mRNA

NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137

G

cyclin-dependent kinase 4

increases expression

Glafenine results in increased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

Glafenine results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

Glafenine results in decreased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 3

decreases expression

Glafenine results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cysteine dioxygenase type 1

decreases expression

Glafenine results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

CEA cell adhesion molecule 1

decreases expression

Glafenine results in decreased expression of CEACAM1 mRNA

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

CCAAT/enhancer binding protein delta

increases expression

Glafenine results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

cell migration inducing hyaluronidase 2

increases expression

Glafenine results in increased expression of CEMIP2 mRNA

NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760

G

choline/ethanolamine phosphotransferase 1

decreases expression

Glafenine results in decreased expression of CEPT1 mRNA

NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578

G

carboxylesterase 1D

decreases expression

Glafenine results in decreased expression of CES1D mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

decreases expression

Glafenine results in decreased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

coiled-coil-helix-coiled-coil-helix domain containing 6

increases expression

Glafenine results in increased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

chitinase domain containing 1

increases expression

Glafenine results in increased expression of CHID1 mRNA

NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606

G

charged multivesicular body protein 4C

decreases expression

Glafenine results in decreased expression of CHMP4C mRNA