chlorocarboxylic acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	chlorocarboxylic acid	go back to main search page
Accession:	CHEBI:36685	browse the term
Definition:	A carboxylic acid containing at least one chloro group.
Synonyms:	related_synonym:	chlorocarboxylic acids

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Rat (1035) Mouse (1037) Human (1095) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (1035)

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chloroacetic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

SB 203580 inhibits the reaction [chloroacetic acid results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

chloroacetic acid results in decreased expression of BCL2 mRNA
SB 203580 inhibits the reaction [chloroacetic acid results in decreased expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calpain 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein]

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein]

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caspase 12

multiple interactions

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases cleavage

chloroacetic acid results in increased cleavage of and results in increased activity of CASP3 protein; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP3 protein]

PMID:23103613 PMID:25451595

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

chloroacetic acid results in increased cleavage of and results in increased activity of CASP7 protein; SB 203580 inhibits the reaction [chloroacetic acid results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases cleavage

chloroacetic acid results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]
chloroacetic acid results in increased expression of DDIT3 mRNA; chloroacetic acid results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2A

increases phosphorylation
multiple interactions

chloroacetic acid results in increased phosphorylation of EIF2A protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

chloroacetic acid results in decreased expression of G6PC1 mRNA; chloroacetic acid results in decreased expression of G6PC1 protein

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glyceraldehyde-3-phosphate dehydrogenase

decreases activity

chloroacetic acid results in decreased activity of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glycerol kinase

decreases expression
multiple interactions

chloroacetic acid results in decreased expression of GK mRNA
[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in decreased expression of GK mRNA

NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631

G

heme oxygenase 1

multiple interactions

[vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein 90 beta family member 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSP90B1 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSP90B1 mRNA; chloroacetic acid results in increased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; HSPA5 protein promotes the reaction [chloroacetic acid results in increased cleavage of CASP3 protein]
chloroacetic acid results in increased expression of HSPA5 mRNA; chloroacetic acid results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[vinylidene chloride co-treated with chloroacetic acid] results in increased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

insulin-like growth factor 1

decreases expression

chloroacetic acid results in decreased expression of IGF1 mRNA; chloroacetic acid results in decreased expression of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

myelin basic protein

affects expression

chloroacetic acid affects the expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

chloroacetic acid results in decreased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

microRNA 451a

multiple interactions
increases expression

[ethylene dichloride metabolite results in increased abundance of chloroacetic acid] which results in increased expression of MIR451A mRNA
chloroacetic acid results in increased expression of MIR451A mRNA

NCBI chr10:62,961,520...62,961,591
Ensembl chr10:62,961,520...62,961,591

G

poly (ADP-ribose) polymerase 1

increases cleavage

chloroacetic acid results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

glycogen phosphorylase L

decreases expression

chloroacetic acid results in decreased expression of PYGL mRNA; chloroacetic acid results in decreased expression of PYGL protein

NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310

G

X-box binding protein 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]
chloroacetic acid results in increased expression of XBP1 mRNA alternative form; chloroacetic acid results in increased expression of XBP1 protein alternative form

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

chloropropylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Dihydrotestosterone inhibits the reaction [chloropropylate results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

estrogen receptor 1

increases activity

chloropropylate results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases activity

chloropropylate results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

chloropropylate binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

furosemide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]
[Furosemide results in increased activity of ABCC2 protein] promotes the reaction [Glucose results in increased secretion of S-(2,4-dinitrophenyl)glutathione]

PMID:12704183 PMID:19782883

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases export
increases transport

ABCC4 protein results in increased export of Furosemide
ABCC4 protein results in increased transport of Furosemide

PMID:17135398 PMID:17939016

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

affects expression

Furosemide affects the expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

angiotensinogen

increases expression

Furosemide results in increased expression of AGT protein modified form

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

affects phosphorylation

Furosemide affects the phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
affects binding

[bucolome inhibits the reaction [Furosemide binds to ALB protein]] which affects the abundance of Furosemide; bucolome inhibits the reaction [Furosemide binds to ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression

Furosemide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

angiogenin

affects expression

Furosemide affects the expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

angiopoietin 2

affects expression

Furosemide affects the expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

apoptotic peptidase activating factor 1

affects expression

Furosemide affects the expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

aquaporin 2

increases expression

Furosemide results in increased expression of AQP2 mRNA; Furosemide results in increased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

activity-regulated cytoskeleton-associated protein

affects expression

Furosemide affects the expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ATM serine/threonine kinase

affects expression

Furosemide affects the expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase H+ transporting V1 subunit B1

multiple interactions
increases expression

[Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein
Furosemide results in increased expression of ATP6V1B1 protein

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

arginine vasopressin receptor 2

increases expression

Furosemide results in increased expression of AVPR2 mRNA

NCBI chr X:151,633,501...151,636,155
Ensembl chr X:151,633,522...151,635,989

G

BCL2-associated agonist of cell death

affects expression

Furosemide affects the expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

affects expression

Furosemide affects the expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

affects expression

Furosemide affects the expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL10, immune signaling adaptor

affects expression

Furosemide affects the expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

affects expression

Furosemide affects the expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 10

affects expression

Furosemide affects the expression of BCL2L10 mRNA

NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367

G

Bcl2-like 11

affects expression

Furosemide affects the expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

Bcl2-like 2

affects expression

Furosemide affects the expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BH3 interacting domain death agonist

affects expression

Furosemide affects the expression of BID mRNA

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BCL2-interacting killer

affects expression

Furosemide affects the expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 2

affects expression

Furosemide affects the expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 5

affects expression

Furosemide affects the expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

baculoviral IAP repeat-containing 6

affects expression

Furosemide affects the expression of BIRC6 mRNA

NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434

G

basic helix-loop-helix ARNT like 1

decreases secretion

BMAL1 gene mutant form results in decreased secretion of Furosemide

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BCL2 family apoptosis regulator BOK

affects expression

Furosemide affects the expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

barttin CLCNK type accessory subunit beta

decreases expression

Furosemide results in decreased expression of BSND mRNA

NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571

G

calbindin 1

increases expression

Furosemide results in increased expression of CALB1 mRNA; Furosemide results in increased expression of CALB1 protein

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

carbonic anhydrase 2

decreases activity
increases expression

Furosemide results in decreased activity of CA2 protein
Furosemide results in increased expression of CA2 mRNA

PMID:16858005 PMID:28138970

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

caspase 1

affects expression

Furosemide affects the expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

affects expression

Furosemide affects the expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 14

affects expression

Furosemide affects the expression of CASP14 mRNA

NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405

G

caspase 2

affects expression

Furosemide affects the expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

affects expression

Furosemide affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

affects expression

Furosemide affects the expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

affects expression

Furosemide affects the expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 8

affects expression

Furosemide affects the expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

affects expression

Furosemide affects the expression of CASP9 mRNA

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

CD40 molecule

affects expression

Furosemide affects the expression of CD40 mRNA

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd70 molecule

affects expression

Furosemide affects the expression of CD70 mRNA

NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715

G

cadherin 5

decreases expression

Furosemide results in decreased expression of CDH5 mRNA

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

checkpoint kinase 1

affects expression

Furosemide affects the expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

affects expression

Furosemide affects the expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

chromogranin A

increases expression

Furosemide results in increased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

cell death-inducing DFFA-like effector a

affects expression

Furosemide affects the expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector b

affects expression

Furosemide affects the expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

chloride voltage-gated channel Ka

decreases expression

Furosemide results in decreased expression of CLCNKA mRNA

NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148

G

collagen type XVIII alpha 1 chain

decreases expression

Furosemide results in decreased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

CASP2 and RIPK1 domain containing adaptor with death domain

affects expression

Furosemide affects the expression of CRADD mRNA

NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907

G

colony stimulating factor 3

increases expression

Furosemide results in increased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

death-associated protein kinase 2

affects expression

Furosemide affects the expression of DAPK2 mRNA

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

DNA-damage inducible transcript 3

increases expression

Furosemide results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA fragmentation factor subunit alpha

affects expression

Furosemide affects the expression of DFFA mRNA

NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633

G

ephrin A5

increases expression

Furosemide results in increased expression of EFNA5 mRNA

NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413

G

Fas associated via death domain

affects expression

Furosemide affects the expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas ligand

affects expression

Furosemide affects the expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 16

affects expression

Furosemide affects the expression of FGF16 mRNA

NCBI chr X:70,816,658...70,828,028
Ensembl chr X:70,817,433...70,878,717

G

fibroblast growth factor 2

decreases expression

Furosemide results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 4

increases expression

Furosemide results in increased expression of FGF4 mRNA

NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466

G

fibroblast growth factor receptor 4

affects expression

Furosemide affects the expression of FGFR4 mRNA

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

Fms related receptor tyrosine kinase 1

increases expression

Furosemide results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Furosemide results in increased expression of FOS protein
Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]

PMID:10760498 PMID:15528393

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucose-6-phosphate dehydrogenase

decreases activity

Furosemide results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

gamma-aminobutyric acid type A receptor subunit alpha 4

decreases activity

Furosemide results in decreased activity of GABRA4 protein

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

glutamate decarboxylase 1

decreases expression

Furosemide results in decreased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

affects expression

Furosemide affects the expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione-disulfide reductase

decreases activity

Furosemide results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

high mobility group box 1

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

increases expression
multiple interactions

Furosemide results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA; [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA

PMID:24813929 PMID:29860548

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

harakiri, BCL2 interacting protein

affects expression

Furosemide affects the expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

hydroxysteroid 11-beta dehydrogenase 1

decreases activity

Furosemide results in decreased activity of HSD11B1 protein

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock transcription factor 1

increases activity

Furosemide results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

HUS1 checkpoint clamp component

affects expression

Furosemide affects the expression of HUS1 mRNA

NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442

G

inhibitor of DNA binding 1

decreases expression

Furosemide results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 3

decreases expression

Furosemide results in decreased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

interferon, alpha 1

increases expression

Furosemide results in increased expression of IFNA1 mRNA

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

insulin-like growth factor 1

increases expression

Furosemide results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

decreases secretion

Furosemide results in decreased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 6

decreases secretion

Furosemide results in decreased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha 5

decreases expression

Furosemide results in decreased expression of ITGA5 mRNA

NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837

G

kinase insert domain receptor

increases expression

Furosemide results in increased expression of KDR mRNA

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

lymphotoxin alpha

affects expression

Furosemide affects the expression of LTA mRNA

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

lymphotoxin beta

affects expression

Furosemide affects the expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

lymphotoxin beta receptor

affects expression

Furosemide affects the expression of LTBR mRNA

NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539

G

midkine

increases expression

Furosemide results in increased expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

MDM2 proto-oncogene

affects expression

Furosemide affects the expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

macrophage scavenger receptor 1

increases expression

Furosemide results in increased expression of MSR1 mRNA

NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676

G

metallothionein 1

increases expression

Furosemide results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

NLR family, apoptosis inhibitory protein 6

affects expression

Furosemide affects the expression of NAIP2 mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

NFE2 like bZIP transcription factor 2

increases localization
decreases response to substance

Furosemide results in increased localization of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Furosemide

PMID:18078705 PMID:24813929

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NLR family, pyrin domain containing 3

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nucleolar protein 3

affects expression

Furosemide affects the expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nitric oxide synthase 3

affects expression

Furosemide affects the expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

decreases expression

Furosemide results in decreased expression of NPPA protein

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

platelet derived growth factor receptor alpha

affects expression

Furosemide affects the expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

increases expression

Furosemide results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

platelet and endothelial cell adhesion molecule 1

increases expression

Furosemide results in increased expression of PECAM1 mRNA

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

platelet factor 4

decreases expression

Furosemide results in decreased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

phosphogluconate dehydrogenase

decreases activity

Furosemide results in decreased activity of PGD protein

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

placental growth factor

decreases expression

Furosemide results in decreased expression of PGF mRNA

NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685

G

PTEN induced kinase 1

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein

NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prostaglandin E receptor 4

multiple interactions

PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin-endoperoxide synthase 1

affects expression

Furosemide affects the expression of PTGS1 mRNA; Furosemide affects the expression of PTGS1 protein

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions
increases expression

Furosemide affects the expression of PTGS2 mRNA; Furosemide affects the expression of PTGS2 protein
[Furosemide results in increased expression of PTGS2 mRNA] which results in increased abundance of Prostaglandins; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]
Furosemide results in increased expression of PTGS2 mRNA; Furosemide results in increased expression of PTGS2 protein

PMID:11135058 PMID:11703585 PMID:11961000 PMID:19031110

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

increases expression
multiple interactions

Furosemide results in increased expression of PTH protein
NPS R-467 inhibits the reaction [Furosemide results in increased expression of PTH protein]

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

pleiotrophin

affects expression

Furosemide affects the expression of PTN mRNA

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

renin

multiple interactions
increases expression
increases secretion
increases activity

Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]; Indomethacin inhibits the reaction [Furosemide results in increased expression of REN protein]; Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein]; Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Furosemide results in increased secretion of REN protein
Furosemide results in increased expression of REN mRNA; Furosemide results in increased expression of REN protein
PTGER4 protein affects the reaction [Furosemide results in increased expression of REN mRNA]; PTGER4 protein affects the reaction [Furosemide results in increased expression of REN protein]

PMID:599795 PMID:1924052 PMID:3530574 PMID:4028619 PMID:7954537 More...

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

receptor interacting serine/threonine kinase 1

affects expression

Furosemide affects the expression of RIPK1 mRNA

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

G

replication protein A3

affects expression

Furosemide affects the expression of RPA3 mRNA

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

S100 calcium binding protein B

multiple interactions

[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

S100 calcium binding protein G

affects expression

Furosemide affects the expression of S100G mRNA

NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433

G

sphingosine-1-phosphate receptor 1

increases expression

Furosemide results in increased expression of S1PR1 mRNA

NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681

G

serpin family B member 5

increases expression

Furosemide results in increased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

serpin family F member 1

affects expression

Furosemide affects the expression of SERPINF1 mRNA

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

solute carrier family 12 member 1

decreases activity

Furosemide results in decreased activity of SLC12A1 protein

NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899

G

solute carrier family 12 member 2

multiple interactions
decreases activity

[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] inhibits the reaction [Ammonia results in increased secretion of S100B protein]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]; [Furosemide results in decreased activity of SLC12A2 protein] which results in decreased susceptibility to Ammonia; [Furosemide results in decreased activity of SLC12A2 protein] which results in increased activity of Ammonia
Furosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]

PMID:23880158 PMID:29959396

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 12 member 5

decreases activity
multiple interactions

Furosemide results in decreased activity of SLC12A5 protein
Furosemide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]

PMID:18094240 PMID:20086212

NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765

G

solute carrier family 12 member 7

decreases activity

Furosemide results in decreased activity of SLC12A7 protein

NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302

G

solute carrier family 22, member 19

multiple interactions

Furosemide inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]

NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538

G

solute carrier family 22 member 6

increases expression
increases secretion
decreases activity

Furosemide results in increased expression of SLC22A6 protein
SLC22A6 protein results in increased secretion of Furosemide
Furosemide results in decreased activity of SLC22A6 protein

PMID:12897087 PMID:18216144

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 7

multiple interactions

Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

decreases activity
multiple interactions
increases secretion

Furosemide results in decreased activity of SLC22A8 protein
Furosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
Furosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
SLC22A8 protein results in increased secretion of Furosemide

PMID:10224140 PMID:11306713 PMID:18216144

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 26 member 4

multiple interactions
affects localization

[Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein
Furosemide affects the localization of SLC26A4 protein

NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703

G

secreted protein acidic and cysteine rich

increases expression

Furosemide results in increased expression of SPARC mRNA

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

serine peptidase inhibitor, Kazal type 1

increases expression

Furosemide results in increased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

sequestosome 1

multiple interactions

[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein; iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]; Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

TEK receptor tyrosine kinase

increases expression

Furosemide results in increased expression of TEK mRNA

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

G

transforming growth factor alpha

increases expression

Furosemide results in increased expression of TGFA mRNA

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

affects expression

Furosemide affects the expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

increases expression

Furosemide results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta receptor 1

increases expression

Furosemide results in increased expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

increases expression

Furosemide results in increased expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

thrombospondin 1

affects expression

Furosemide affects the expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

increases expression

Furosemide results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

thrombospondin 3

affects expression

Furosemide affects the expression of THBS3 mRNA

NCBI chr 2:174,621,788...174,633,594
Ensembl chr 2:174,621,812...174,633,594

G

thrombospondin 4

affects expression

Furosemide affects the expression of THBS4 mRNA

NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313

G

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

increases expression

Furosemide results in increased expression of TIE1 mRNA

NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592

G

TIMP metallopeptidase inhibitor 2

affects expression

Furosemide affects the expression of TIMP2 mRNA

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

tumor necrosis factor

decreases secretion
affects expression

Furosemide results in decreased secretion of TNF protein
Furosemide affects the expression of TNF mRNA

PMID:16526316 PMID:16612254 PMID:17497460

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11A

affects expression

Furosemide affects the expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 1A

affects expression

Furosemide affects the expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

affects expression

Furosemide affects the expression of TNFRSF1B mRNA

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF receptor superfamily member 25

affects expression

Furosemide affects the expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

TNF receptor superfamily member 8

affects expression

Furosemide affects the expression of TNFRSF8 mRNA

NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421

G

TNF receptor superfamily member 9

affects expression

Furosemide affects the expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 10

affects expression

Furosemide affects the expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

affects expression

Furosemide affects the expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

TNF superfamily member 12

affects expression

Furosemide affects the expression of TNFSF12 mRNA

NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213

G

TNF superfamily member 13

affects expression

Furosemide affects the expression of TNFSF13 mRNA

NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042

G

TNF superfamily member 8

affects expression

Furosemide affects the expression of TNFSF8 mRNA

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

TNF superfamily member 9

affects expression

Furosemide affects the expression of TNFSF9 mRNA

NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345

G

thiopurine S-methyltransferase

decreases activity

Furosemide results in decreased activity of TPMT protein

NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709

G

TNF receptor-associated factor 5

affects expression

Furosemide affects the expression of TRAF5 mRNA

NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709

G

TNF receptor associated factor 6

affects expression

Furosemide affects the expression of TRAF6 mRNA

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

transient receptor potential cation channel, subfamily V, member 5

increases expression

Furosemide results in increased expression of TRPV5 mRNA; Furosemide results in increased expression of TRPV5 protein

NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745

G

transient receptor potential cation channel, subfamily V, member 6

increases expression

Furosemide results in increased expression of TRPV6 mRNA

NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017

G

UDP glucuronosyltransferase family 1 member A1

increases expression

Furosemide results in increased expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of Furosemide

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

increases expression

Furosemide results in increased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

affects expression

Furosemide affects the expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

increases expression

Furosemide results in increased expression of VEGFC mRNA

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

X-linked inhibitor of apoptosis

affects expression

Furosemide affects the expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

N-(2,6-diethylphenyl)-2-chloroacetamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases chemical synthesis
multiple interactions
increases abundance

CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2,6-diethylphenyl)acetamide
[CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide
CYP3A4 protein results in increased abundance of 2-chloro-N-(2,6-diethylphenyl)acetamide

PMID:10475613 PMID:18273908

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

niclosamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

increases expression

Niclosamide results in increased expression of A1BG mRNA

NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097

G

ATP binding cassette subfamily A member 12

decreases expression

Niclosamide results in decreased expression of ABCA12 mRNA

NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049

G

ATP binding cassette subfamily C member 9

decreases expression

Niclosamide results in decreased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily G member 4

increases expression

Niclosamide results in increased expression of ABCG4 mRNA

NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881

G

abhydrolase domain containing 1

increases expression

Niclosamide results in increased expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514

G

abhydrolase domain containing 14b

increases expression

Niclosamide results in increased expression of ABHD14B mRNA

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

acetyl-CoA carboxylase alpha

decreases expression

Niclosamide results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acid phosphatase 5, tartrate resistant

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]

PMID:26792726 PMID:28824321

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Niclosamide results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of ACTA2 protein]
Niclosamide results in decreased expression of ACTA2 mRNA; Niclosamide results in decreased expression of ACTA2 protein

PMID:26643609 PMID:28318631 PMID:34118929 PMID:35115509 PMID:36870549

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase with thrombospondin type 1 motif, 17

decreases expression

Niclosamide results in decreased expression of ADAMTS17 mRNA

NCBI chr 1:120,445,800...120,768,204
Ensembl chr 1:120,445,749...120,768,202

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Niclosamide results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

adrenomedullin 2

increases expression

Niclosamide results in increased expression of ADM2 mRNA

NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331

G

adrenoceptor alpha 2A

decreases expression

Niclosamide results in decreased expression of ADRA2A mRNA

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

alpha-fetoprotein

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

AGBL carboxypeptidase 3

decreases expression

Niclosamide results in decreased expression of AGBL3 mRNA

NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188

G

apoptosis inducing factor, mitochondria associated 1

increases cleavage

Niclosamide results in increased cleavage of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AT-hook transcription factor

increases expression

Niclosamide results in increased expression of AKNA mRNA

NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]

PMID:20215516 PMID:26792726 PMID:29843133

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Niclosamide results in decreased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 6 family, member A1

increases expression

Niclosamide results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldolase, fructose-bisphosphate B

increases expression

Niclosamide results in increased expression of ALDOB mRNA

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

Niclosamide results in decreased expression of ALDOC mRNA
Niclosamide results in increased expression of ALDOC mRNA

PMID:22576131 PMID:36318118

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkB homolog 7

increases expression

Niclosamide results in increased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

arachidonate 12-lipoxygenase, 12R type

increases expression
decreases response to substance
multiple interactions

Niclosamide results in increased expression of ALOX12B mRNA
ALOX12B protein results in decreased susceptibility to Niclosamide
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

multiple interactions
increases expression
decreases response to substance

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

alkaline phosphatase, biomineralization associated

decreases expression

Niclosamide results in decreased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

anti-Mullerian hormone receptor type 2

increases expression

Niclosamide results in increased expression of AMHR2 mRNA

NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258

G

angiomotin

increases expression

Niclosamide results in increased expression of AMOT mRNA

NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272

G

ankyrin 3

increases expression

Niclosamide results in increased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat and MYND domain containing 2

increases expression

Niclosamide results in increased expression of ANKMY2 mRNA

NCBI chr 6:52,888,959...52,930,343
Ensembl chr 6:52,888,963...52,930,394

G

ankyrin repeat domain 12

increases expression

Niclosamide results in increased expression of ANKRD12 mRNA

NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911

G

ankyrin repeat domain 34A

increases expression

Niclosamide results in increased expression of ANKRD34A mRNA

NCBI chr 2:184,129,830...184,135,075
Ensembl chr 2:184,129,238...184,135,116

G

annexin A4

increases expression

Niclosamide results in increased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

Niclosamide results in decreased expression of AP1S3 mRNA

NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798

G

apelin receptor

decreases expression

Niclosamide results in decreased expression of APLNR mRNA

NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050

G

apolipoprotein F

decreases expression

Niclosamide results in decreased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

androgen receptor

multiple interactions
decreases expression

[enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form

PMID:24740322 PMID:25970160 PMID:28500234

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

Rho GDP dissociation inhibitor beta

increases expression

Niclosamide results in increased expression of ARHGDIB mRNA

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

armadillo repeat containing, X-linked 1

increases expression

Niclosamide results in increased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

arrestin domain containing 2

increases expression

Niclosamide results in increased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

anti-silencing function 1B histone chaperone

decreases expression

Niclosamide results in decreased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

ATCAY kinesin light chain interacting caytaxin

increases expression

Niclosamide results in increased expression of ATCAY mRNA

NCBI chr 7:8,487,763...8,511,527
Ensembl chr 7:8,487,763...8,512,663

G

activating transcription factor 3

increases expression
multiple interactions

Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression

Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

atos homolog B

increases expression

Niclosamide results in increased expression of ATOSB mRNA

NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Niclosamide results in increased expression of ATP2A3 mRNA

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit alpha

increases expression

Niclosamide results in increased expression of ATP5F1A mRNA

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit delta

increases expression

Niclosamide results in increased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase membrane subunit c locus 3

decreases expression

Niclosamide results in decreased expression of ATP5MC3 mRNA

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase membrane subunit f

decreases expression

Niclosamide results in decreased expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase membrane subunit G

decreases expression

Niclosamide results in decreased expression of ATP5MG mRNA

NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559

G

ATP synthase peripheral stalk-membrane subunit b

decreases expression

Niclosamide results in decreased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATPase H+ transporting accessory protein 1

decreases expression

Niclosamide results in decreased expression of ATP6AP1 mRNA

NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034

G

ATPase H+ transporting V0 subunit D2

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

ATP synthase c subunit lysine N-methyltransferase

decreases expression

Niclosamide results in decreased expression of ATPSCKMT mRNA

NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308

G

aurora kinase B

decreases expression

Niclosamide results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

arginine vasopressin-induced 1

increases expression

Niclosamide results in increased expression of AVPI1 mRNA

NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154

G

axin 2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein

PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

increases expression

Niclosamide results in increased expression of B3GNT7 mRNA

NCBI chr 9:86,956,220...86,960,171
Ensembl chr 9:86,956,220...86,960,170

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

increases expression

Niclosamide results in increased expression of B3GNT9 mRNA

NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344

G

BCL2-associated agonist of cell death

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression
decreases expression
multiple interactions

Niclosamide results in increased expression of BAX protein
Niclosamide results in decreased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]

PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 PMID:35115509

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]

PMID:30258081 PMID:36318118

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

Bardet-Biedl syndrome 2

increases expression

Niclosamide results in increased expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]

PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein

PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL3, transcription coactivator

increases expression

Niclosamide results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

multiple interactions
increases expression

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]
Niclosamide results in increased expression of BCL6 mRNA

PMID:33632240 PMID:36318118

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCL6B, transcription repressor

increases expression

Niclosamide results in increased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

BCL9, transcription coactivator

decreases expression

Niclosamide results in decreased expression of BCL9 mRNA

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

G

BCL6 co-repressor-like 1

increases expression

Niclosamide results in increased expression of BCORL1 mRNA

NCBI chr X:127,516,504...127,584,529
Ensembl chr X:127,537,538...127,584,087

G

Bet1 golgi vesicular membrane trafficking protein-like

increases expression

Niclosamide results in increased expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

biglycan

increases expression

Niclosamide results in increased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

increases expression

Niclosamide results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression
affects expression

enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 mRNA; Niclosamide results in decreased expression of BIRC5 protein
Niclosamide affects the expression of BIRC5 protein

PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 More...

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Bcl2 modifying factor

increases expression

Niclosamide results in increased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BLOC-1 related complex subunit 6

increases expression

Niclosamide results in increased expression of BORCS6 mRNA

NCBI chr10:53,760,504...53,762,358
Ensembl chr10:53,758,093...53,762,632

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression
decreases phosphorylation

Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BTB domain containing 7

decreases expression

Niclosamide results in decreased expression of BTBD7 mRNA

NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405

G

BTG anti-proliferation factor 2

increases expression

Niclosamide results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 1 open reading frame 105

decreases expression

Niclosamide results in decreased expression of C1ORF105 mRNA

NCBI chr13:74,313,320...74,356,322
Ensembl chr13:74,313,322...74,356,322

G

similar to human chromosome 8 open reading frame 48

decreases expression

Niclosamide results in decreased expression of C8ORF48 mRNA

NCBI chr16:55,244,744...55,246,642
Ensembl chr16:55,236,322...55,246,650

G

similar to human chromosome 16 open reading frame 86

increases expression

Niclosamide results in increased expression of C16ORF86 mRNA

NCBI chr19:33,596,591...33,598,703
Ensembl chr19:33,595,995...33,598,521

G

complement C1q like 4

increases expression

Niclosamide results in increased expression of C1QL4 mRNA

NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678

G

Cdk5 and Abl enzyme substrate 2

decreases expression

Niclosamide results in decreased expression of CABLES2 mRNA

NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279

G

calcium voltage-gated channel subunit alpha1 E

increases expression

Niclosamide results in increased expression of CACNA1E mRNA

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

G

calcium voltage-gated channel subunit alpha1 H

increases expression

Niclosamide results in increased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel auxiliary subunit gamma 1

increases expression

Niclosamide results in increased expression of CACNG1 mRNA

NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783

G

calcium/calmodulin-dependent protein kinase II alpha

increases expression

Niclosamide results in increased expression of CAMK2A mRNA

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calmodulin regulated spectrin-associated protein family, member 3

increases expression

Niclosamide results in increased expression of CAMSAP3 mRNA

NCBI chr12:1,643,062...1,666,685
Ensembl chr12:1,643,251...1,666,685

G

calcyphosine

increases expression

Niclosamide results in increased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

caspase 1

multiple interactions

[Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases cleavage
multiple interactions
decreases expression
increases expression

Niclosamide results in increased cleavage of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]
Niclosamide results in decreased expression of CASP3 protein
Niclosamide results in increased expression of CASP3 protein modified form
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]

PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases expression

bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form]

PMID:26116531 PMID:28500234

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases cleavage

Niclosamide results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage
increases expression

TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 mRNA; Niclosamide results in increased expression of CASP9 protein modified form

PMID:26116531 PMID:26703449 PMID:30258081 PMID:36318118

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

chromobox 4

increases expression

Niclosamide results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 113

increases expression

Niclosamide results in increased expression of CFAP263 mRNA

NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923

G

coiled-coil domain containing 188

increases expression

Niclosamide results in increased expression of CCDC188 mRNA

NCBI chr11:82,769,735...82,772,062
Ensembl chr11:82,769,473...82,772,114

G

coiled-coil domain containing 68

decreases expression

Niclosamide results in decreased expression of CCDC68 mRNA

NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119

G

C-C motif chemokine ligand 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]

PMID:24561310 PMID:28318631

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin B1

decreases expression

Niclosamide results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B3

decreases expression

Niclosamide results in decreased expression of CCNB3 mRNA

NCBI chr X:15,478,050...15,543,292
Ensembl chr X:15,478,065...15,542,885

G

cyclin D1

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein

PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression
increases expression

Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA

PMID:22576131 PMID:27226553 PMID:36318118

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

decreases expression

Niclosamide results in decreased expression of CCND3 mRNA

PMID:22576131 PMID:27226553

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression

Niclosamide results in decreased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]
Niclosamide results in decreased expression of CCNE2 mRNA

PMID:27542212 PMID:36318118

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G2

multiple interactions
increases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]
Niclosamide results in increased expression of CCNG2 mRNA

PMID:27542212 PMID:36318118

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

C-C motif chemokine receptor 10

increases expression

Niclosamide results in increased expression of CCR10 mRNA

NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988

G

CD27 molecule

increases expression

Niclosamide results in increased expression of CD27 mRNA

NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592

G

CD274 molecule

decreases expression

Niclosamide results in decreased expression of CD274 mRNA; Niclosamide results in decreased expression of CD274 protein

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD40 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD55 molecule (Cromer blood group)

increases expression

Niclosamide results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd68 molecule

increases expression

Niclosamide results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd80 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 37, HSP90 cochaperone

multiple interactions

CDC37 protein binds to and results in increased susceptibility to Niclosamide analog

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

G

cell division cycle 42

decreases expression
decreases phosphorylation

Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

CDC42 effector protein 1

increases expression

Niclosamide results in increased expression of CDC42EP1 mRNA

NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200

G

cell division cycle 6

decreases expression

Niclosamide results in decreased expression of CDC6 mRNA

PMID:28284560 PMID:36318118

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 2

decreases expression

Niclosamide results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 5

decreases expression

Niclosamide results in decreased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 8

decreases expression

Niclosamide results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 1

multiple interactions
increases expression

CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein

PMID:25174399 PMID:26643609 PMID:30143678 PMID:35115509

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 11

decreases expression

Niclosamide results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cadherin 12

multiple interactions

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CDH12 protein]

NCBI chr 2:70,474,679...71,705,369
Ensembl chr 2:70,475,043...71,700,572

G

cadherin 2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]
Niclosamide results in decreased expression of CDH2 protein

PMID:26643609 PMID:34118929

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 4

increases expression

Niclosamide results in increased expression of CDH4 mRNA

NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371

G

cadherin 6

decreases expression

Niclosamide results in decreased expression of CDH6 mRNA

NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228

G

cadherin-related family member 1

increases expression

Niclosamide results in increased expression of CDHR1 mRNA

NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396

G

cadherin-related family member 2

decreases expression

Niclosamide results in decreased expression of CDHR2 mRNA

NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575

G

cyclin-dependent kinase 15

decreases expression

Niclosamide results in decreased expression of CDK15 mRNA

NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777

G

cyclin dependent kinase 2

decreases expression

Niclosamide results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression

Niclosamide results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase-like 3

increases expression

Niclosamide results in increased expression of CDKL3 mRNA

NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 3

decreases expression

Niclosamide results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein beta

increases expression

Niclosamide results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CUGBP, Elav-like family member 6

increases expression

Niclosamide results in increased expression of CELF6 mRNA

NCBI chr 8:59,975,095...60,006,060
Ensembl chr 8:59,975,088...60,005,041

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

Niclosamide results in increased expression of CELSR3 mRNA

NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354

G

centromere protein A

decreases expression

Niclosamide results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein O

decreases expression

Niclosamide results in decreased expression of CENPO mRNA

NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314

G

centromere protein U

decreases expression

Niclosamide results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

cilia and flagella associated protein 70

increases expression

Niclosamide results in increased expression of CFAP70 mRNA

NCBI chr15:3,852,381...3,918,036
Ensembl chr15:3,852,509...3,918,014

G

complement factor properdin

increases expression

Niclosamide results in increased expression of CFP mRNA

NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Niclosamide results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

decreases expression

Niclosamide results in decreased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

chromatin assembly factor 1 subunit A

decreases expression

Niclosamide results in decreased expression of CHAF1A mRNA

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

cholinergic receptor nicotinic beta 1 subunit

increases expression

Niclosamide results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

carbohydrate sulfotransferase 8

increases expression

Niclosamide results in increased expression of CHST8 mRNA

NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytokine inducible SH2-containing protein

increases expression

Niclosamide results in increased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

C-type lectin domain containing 11A

increases expression

Niclosamide results in increased expression of CLEC11A mRNA

NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633

G

CAP-GLY domain containing linker protein 2

increases expression

Niclosamide results in increased expression of CLIP2 mRNA

NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023

G

CAP-GLY domain containing linker protein 3

increases expression

Niclosamide results in increased expression of CLIP3 mRNA

NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184

G

claspin

decreases expression

Niclosamide results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

calsyntenin 3

increases expression

Niclosamide results in increased expression of CLSTN3 mRNA

NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769

G

chemerin chemokine-like receptor 1

decreases expression

Niclosamide results in decreased expression of CMKLR1 mRNA

NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129

G

cytidine/uridine monophosphate kinase 2

decreases expression

Niclosamide results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

cyclic nucleotide binding domain containing 2

increases expression

Niclosamide results in increased expression of CNBD2 mRNA

NCBI chr 3:144,819,166...144,884,825
Ensembl chr 3:144,819,195...144,901,583

G

calponin 1

increases expression

Niclosamide results in increased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

calponin 2

increases expression

Niclosamide results in increased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

Niclosamide results in decreased expression of COL1A1 mRNA
Niclosamide results in decreased expression of COL1A1 protein
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]

PMID:28824321 PMID:35115509

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type VI alpha 2 chain

increases expression

Niclosamide results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collectin subfamily member 10

increases expression

Niclosamide results in increased expression of COLEC10 mRNA

NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675

G

cytochrome c oxidase subunit 8C

increases expression

Niclosamide results in increased expression of COX8C mRNA

NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889

G

crumbs cell polarity complex component 2

increases expression

Niclosamide results in increased expression of CRB2 mRNA

NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294

G

CREB binding protein

increases expression

Niclosamide results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

CREB3 regulatory factor

increases expression

Niclosamide results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

cytokine receptor-like factor 1

decreases expression

Niclosamide results in decreased expression of CRLF1 mRNA

NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997

G

carnitine O-octanoyltransferase

decreases expression

Niclosamide results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

crystallin, beta B1

increases expression

Niclosamide results in increased expression of CRYBB1 mRNA

NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344

G

crystallin, lambda 1

increases expression

Niclosamide results in increased expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

colony stimulating factor 1

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

chondroitin sulfate N-acetylgalactosaminyltransferase 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]

NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319

G

casein kinase 1, epsilon

increases expression

Niclosamide results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

G

cysteine and serine rich nuclear protein 1

increases expression

Niclosamide results in increased expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

C-terminal binding protein 1

increases expression

Niclosamide results in increased expression of CTBP1 mRNA

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

catenin beta 1

increases expression
multiple interactions
decreases expression
decreases activity
increases ubiquitination
affects localization

Niclosamide results in increased expression of CTNNB1 mRNA
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]; Niclosamide results in decreased expression of and results in increased phosphorylation of CTNNB1 protein
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide affects the localization of CTNNB1 protein

PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

catenin, beta-interacting protein 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]
Niclosamide results in increased expression of CTNNBIP1 mRNA

PMID:24534281 PMID:36318118

NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939

G

cathepsin C

decreases expression

Niclosamide results in decreased expression of CTSC protein

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin D

decreases expression

Niclosamide results in decreased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 12

decreases expression

Niclosamide results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 5

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]

NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893

G

cytochrome b-561

decreases expression

Niclosamide results in decreased expression of CYB561 mRNA

NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787

G

cytochrome c, somatic

increases expression

Niclosamide results in increased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Niclosamide results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression

Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA

PMID:11124226 PMID:28284560

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

Niclosamide results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Niclosamide results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 39, subfamily a, polypeptide 1

increases expression

Niclosamide results in increased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Niclosamide results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dishevelled-binding antagonist of beta-catenin 3

increases expression

Niclosamide results in increased expression of DACT3 mRNA

NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630

G

D-box binding PAR bZIP transcription factor

increases expression

Niclosamide results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DDAH family member 2, ADMA-independent

increases expression

Niclosamide results in increased expression of DDAH2 mRNA

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

DNA damage-induced apoptosis suppressor

decreases expression

Niclosamide results in decreased expression of DDIAS mRNA

NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]

PMID:26917416 PMID:36318118

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

Niclosamide results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 1

increases expression

Niclosamide results in increased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

2,4-dienoyl-CoA reductase 1

decreases expression

Niclosamide results in decreased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

DGCR8 microprocessor complex subunit

decreases expression

Niclosamide results in decreased expression of DGCR8 mRNA

NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242

G

diacylglycerol kinase, beta

increases expression

Niclosamide results in increased expression of DGKB mRNA

NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043

G

dihydrofolate reductase

decreases expression

Niclosamide results in decreased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dehydrogenase/reductase 3

increases expression

Niclosamide results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

Niclosamide results in decreased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

discs large MAGUK scaffold protein 4

increases expression

Niclosamide results in increased expression of DLG4 mRNA

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

distal membrane arm assembly component 2 like

decreases expression

Niclosamide results in decreased expression of DMAC2L mRNA

NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

Niclosamide results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

Niclosamide results in decreased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member C22

increases expression

Niclosamide results in increased expression of DNAJC22 mRNA

NCBI chr 7:130,257,504...130,262,880
Ensembl chr 7:130,257,851...130,263,230

G

DnaJ heat shock protein family (Hsp40) member C9

decreases expression

Niclosamide results in decreased expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

dedicator of cytokinesis 5

decreases expression

Niclosamide results in decreased expression of DOCK5 mRNA

NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649

G

DEAQ box RNA-dependent ATPase 1

increases expression

Niclosamide results in increased expression of DQX1 mRNA

NCBI chr 4:115,563,497...115,572,598
Ensembl chr 4:115,563,752...115,572,590

G

dopamine receptor D4

increases expression

Niclosamide results in increased expression of DRD4 mRNA

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

DNA replication and sister chromatid cohesion 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

Niclosamide results in decreased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dual specificity phosphatase 4

increases expression

Niclosamide results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 8

increases expression

Niclosamide results in increased expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

dual specificity phosphatase 9

increases expression

Niclosamide results in increased expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

dishevelled segment polarity protein 1

increases expression

Niclosamide results in increased expression of DVL1 mRNA

NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664

G

dishevelled segment polarity protein 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]

PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231

NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820

G

dishevelled segment polarity protein 3

increases expression

Niclosamide results in increased expression of DVL3 mRNA

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

dual specificity tyrosine phosphorylation regulated kinase 1B

increases expression

Niclosamide results in increased expression of DYRK1B mRNA

NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169

G

E2F transcription factor 1

decreases expression

Niclosamide results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

decreases expression

Niclosamide results in decreased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 7

decreases expression

Niclosamide results in decreased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

decreases expression

Niclosamide results in decreased expression of E2F8 mRNA

PMID:28284560 PMID:36318118

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

ELL associated factor 2

decreases expression

Niclosamide results in decreased expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

EBF transcription factor 1

decreases expression

Niclosamide results in decreased expression of EBF1 mRNA

NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665

G

EBF family member 4

increases expression

Niclosamide results in increased expression of EBF4 mRNA

NCBI chr 3:117,498,186...117,566,566
Ensembl chr 3:117,498,319...117,566,566

G

ethylmalonyl-CoA decarboxylase 1

decreases expression

Niclosamide results in decreased expression of ECHDC1 mRNA

NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319

G

enoyl CoA hydratase domain containing 2

decreases expression

Niclosamide results in decreased expression of ECHDC2 mRNA

NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859

G

enoyl-CoA hydratase, short chain 1

decreases expression

Niclosamide results in decreased expression of ECHS1 mRNA

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

ephrin A1

increases expression

Niclosamide results in increased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

ephrin A3

increases expression

Niclosamide results in increased expression of EFNA3 mRNA

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

ephrin B3

increases expression

Niclosamide results in increased expression of EFNB3 mRNA

NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471

G

epidermal growth factor

decreases expression
multiple interactions

Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]; Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

PMID:30779072 PMID:38185387

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression
decreases phosphorylation
multiple interactions

Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
Niclosamide results in decreased phosphorylation of EGFR protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]

PMID:28284560 PMID:28426875 PMID:30779072 PMID:38185387

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
decreases expression

Niclosamide results in increased expression of EGR1 mRNA
Niclosamide results in decreased expression of EGR1 mRNA

PMID:28284560 PMID:36318118

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Niclosamide results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4A2

increases expression

Niclosamide results in increased expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E

multiple interactions

Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

decreases expression
decreases phosphorylation
multiple interactions

Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

PMID:19771169 PMID:28284560 PMID:30258081

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

E74 like ETS transcription factor 1

increases expression

Niclosamide results in increased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

extracellular leucine-rich repeat and fibronectin type III domain containing 1

increases expression

Niclosamide results in increased expression of ELFN1 mRNA

NCBI chr12:14,660,049...14,725,709
Ensembl chr12:14,660,083...14,724,580

G

EMAP like 2

increases expression

Niclosamide results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

endonuclease domain containing 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

G

endoglin

increases expression

Niclosamide results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 2

increases expression

Niclosamide results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

enolase 3

decreases expression

Niclosamide results in decreased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

E1A binding protein p300

increases expression

Niclosamide results in increased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

multiple interactions

Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor A8

increases expression

Niclosamide results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

EPS8 like 3

increases expression

Niclosamide results in increased expression of EPS8L3 mRNA

NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085

G

ETHE1, persulfide dioxygenase

increases expression

Niclosamide results in increased expression of ETHE1 mRNA

NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052

G

eva-1 homolog B

increases expression

Niclosamide results in increased expression of EVA1B mRNA

NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433

G

exonuclease 5

decreases expression

Niclosamide results in decreased expression of EXO5 mRNA

NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772

G

exo/endonuclease G

decreases expression

Niclosamide results in decreased expression of EXOG mRNA

NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672

G

coagulation factor X

increases expression

Niclosamide results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor XII

increases expression

Niclosamide results in increased expression of F12 mRNA

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

family with sequence similarity 131, member C

increases expression

Niclosamide results in increased expression of FAM131C mRNA

NCBI chr 5:153,674,459...153,690,791
Ensembl chr 5:153,671,772...153,690,800

G

family with sequence similarity 135, member B

increases expression

Niclosamide results in increased expression of FAM135B mRNA

NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708

G

family with sequence similarity 13, member B

decreases expression

Niclosamide results in decreased expression of FAM13B mRNA

NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587

G

family with sequence similarity 221, member A

increases expression

Niclosamide results in increased expression of FAM221A mRNA

NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909

G

family with sequence similarity 43, member A

increases expression

Niclosamide results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 43, member B

increases expression

Niclosamide results in increased expression of FAM43B mRNA

NCBI chr 5:150,610,656...150,613,054
Ensembl chr 5:150,611,609...150,612,601

G

family with sequence similarity 83, member D

decreases expression

Niclosamide results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

FA complementation group B

decreases expression

Niclosamide results in decreased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

Fas cell surface death receptor

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]

PMID:28318631 PMID:33632240

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

FAST kinase domains 3

decreases expression

Niclosamide results in decreased expression of FASTKD3 mRNA

NCBI chr 1:34,858,342...34,866,988
Ensembl chr 1:34,858,219...34,866,973

G

F-box protein 2

increases expression

Niclosamide results in increased expression of FBXO2 mRNA

NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355

G

F-box protein 48

increases expression

Niclosamide results in increased expression of FBXO48 mRNA

NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314

G

FCH and mu domain containing endocytic adaptor 1

increases expression

Niclosamide results in increased expression of FCHO1 mRNA

NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104

G

Fc receptor-like B

increases expression

Niclosamide results in increased expression of FCRLB mRNA

NCBI chr13:83,148,685...83,157,157
Ensembl chr13:83,149,751...83,155,957

G

flap structure-specific endonuclease 1

decreases expression

Niclosamide results in decreased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FYVE, RhoGEF and PH domain containing 1

increases expression

Niclosamide results in increased expression of FGD1 mRNA

NCBI chr X:20,023,746...20,066,734
Ensembl chr X:20,023,746...20,066,566

G

fibroblast growth factor 1

decreases expression

Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 19

increases expression

Niclosamide results in increased expression of FGF19 mRNA

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

fibroblast growth factor receptor 4

increases expression

Niclosamide results in increased expression of FGFR4 mRNA

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fidgetin-like 1

decreases expression

Niclosamide results in decreased expression of FIGNL1 mRNA

NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455

G

FKBP prolyl isomerase 5

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fibronectin leucine rich transmembrane protein 3

decreases expression

Niclosamide results in decreased expression of FLRT3 mRNA

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

formin 1

increases expression

Niclosamide results in increased expression of FMN1 mRNA

NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220

G

fibronectin 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 10

increases expression

Niclosamide results in increased expression of FNDC10 mRNA

NCBI chr 5:166,299,587...166,311,477
Ensembl chr 5:166,300,122...166,310,326

G

fibronectin type III domain containing 4

increases expression

Niclosamide results in increased expression of FNDC4 mRNA

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]

PMID:26792726 PMID:28824321

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box L1

increases expression

Niclosamide results in increased expression of FOXL1 mRNA

NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425

G

forkhead box M1

multiple interactions
decreases expression

Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein]

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O4

increases expression

Niclosamide results in increased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

forkhead box O6

increases expression

Niclosamide results in increased expression of FOXO6 mRNA

NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573

G

FRAT regulator of WNT signaling pathway 2

increases expression

Niclosamide results in increased expression of FRAT2 mRNA

NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517

G

frizzled-related protein

increases expression

Niclosamide results in increased expression of FRZB mRNA

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

fascin actin-bundling protein 1

multiple interactions

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

follistatin like 3

increases expression

Niclosamide results in increased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

frizzled class receptor 1

affects localization

Niclosamide affects the localization of FZD1 protein

NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643

G

frizzled class receptor 2

decreases expression
increases expression

Niclosamide results in decreased expression of FZD2 mRNA
Niclosamide results in increased expression of FZD2 mRNA

PMID:22576131 PMID:36318118

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

frizzled class receptor 5

increases expression

Niclosamide results in increased expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

frizzled class receptor 9

decreases expression

Niclosamide results in decreased expression of FZD9 mRNA

NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398

G

G4 protein

affects expression

Niclosamide affects the expression of C6ORF47 mRNA

NCBI chr20:3,693,691...3,696,194
Ensembl chr20:3,693,649...3,696,088

G

GRB2-associated binding protein 2

increases expression

Niclosamide results in increased expression of GAB2 mRNA

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

GABA type A receptor associated protein like 1

increases expression

Niclosamide results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Niclosamide results in increased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

Niclosamide results in increased expression of GABRB1 mRNA

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

growth arrest and DNA-damage-inducible, beta

increases expression

Niclosamide results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

golgi associated RAB2 interactor 1A

increases expression

Niclosamide results in increased expression of GARIN1A mRNA

NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820

G

GATA binding protein 5

increases expression

Niclosamide results in increased expression of GATA5 mRNA

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751

G

glucagon

multiple interactions

Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutamate cysteine ligase, modifier subunit

decreases expression

Niclosamide results in decreased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

Niclosamide results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 5

increases expression

Niclosamide results in increased expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

GDP-D-glucose phosphorylase 1

decreases expression

Niclosamide results in decreased expression of GDPGP1 mRNA

NCBI chr 1:134,184,119...134,193,281
Ensembl chr 1:134,183,696...134,219,783

G

glial fibrillary acidic protein

decreases expression

Niclosamide results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GID complex subunit 4

increases expression

Niclosamide results in increased expression of GID4 mRNA

NCBI chr10:45,221,556...45,247,627
Ensembl chr10:45,245,754...45,247,621
Ensembl chr10:45,245,754...45,247,621

G

GINS complex subunit 1

decreases expression

Niclosamide results in decreased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

G

GINS complex subunit 2

decreases expression

Niclosamide results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

GINS complex subunit 3

decreases expression

Niclosamide results in decreased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

GINS complex subunit 4

decreases expression

Niclosamide results in decreased expression of GINS4 mRNA

NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273

G

galactosidase, beta 1-like 3

decreases expression

Niclosamide results in decreased expression of GLB1L3 mRNA

NCBI chr 8:25,179,165...25,220,904
Ensembl chr 8:25,179,165...25,220,904

G

GLIS family zinc finger 1

increases expression

Niclosamide results in increased expression of GLIS1 mRNA

NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141

G

GLIS family zinc finger 2

increases expression

Niclosamide results in increased expression of GLIS2 mRNA

NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578

G

G protein subunit gamma 7

increases expression

Niclosamide results in increased expression of GNG7 mRNA

NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240

G

golgin A2

increases expression

Niclosamide results in increased expression of GOLGA2 mRNA

NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279

G

golgi SNAP receptor complex member 2

decreases expression

Niclosamide results in decreased expression of GOSR2 mRNA

NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625

G

glutamic-oxaloacetic transaminase 2

increases expression

Niclosamide results in increased expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycoprotein Ib platelet subunit beta

increases expression

Niclosamide results in increased expression of GP1BB mRNA

NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392

G

glypican 2

increases expression

Niclosamide results in increased expression of GPC2 mRNA

NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208

G

G protein-coupled receptor 153

increases expression

Niclosamide results in increased expression of GPR153 mRNA

NCBI chr 5:162,781,587...162,792,975
Ensembl chr 5:162,781,587...162,792,971

G

G protein-coupled receptor 75

decreases expression

Niclosamide results in decreased expression of GPR75 mRNA

NCBI chr14:104,609,542...104,618,885
Ensembl chr14:104,611,089...104,620,370

G

G protein-coupled receptor, class C, group 5, member C

increases expression

Niclosamide results in increased expression of GPRC5C mRNA

NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926

G

gremlin 2, DAN family BMP antagonist

decreases expression

Niclosamide results in decreased expression of GREM2 mRNA

NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615

G

glutamate ionotropic receptor kainate type subunit 5

increases expression

Niclosamide results in increased expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression

Niclosamide results in increased expression of GRIN2D mRNA

NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793

G

glutamate receptor interacting protein 2

increases expression

Niclosamide results in increased expression of GRIP2 mRNA

NCBI chr 4:124,271,456...124,356,538
Ensembl chr 4:124,271,456...124,321,268

G

glycogen synthase kinase 3 beta

decreases expression
decreases phosphorylation
increases phosphorylation

Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in decreased phosphorylation of GSK3B protein
Niclosamide results in increased phosphorylation of GSK3B protein

PMID:22576131 PMID:30143678 PMID:35115509

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase theta 2

decreases expression

Niclosamide results in decreased expression of GSTT2 mRNA

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

general transcription factor 2H subunit 4

decreases expression
increases expression

Niclosamide results in decreased expression of GTF2H4 mRNA
Niclosamide results in increased expression of GTF2H4 mRNA

NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984

G

G-2 and S-phase expressed 1

decreases expression

Niclosamide results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

glucoside xylosyltransferase 2

increases expression

Niclosamide results in increased expression of GXYLT2 mRNA

NCBI chr 4:133,347,230...133,449,708
Ensembl chr 4:133,347,499...133,449,454

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Niclosamide results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hepcidin antimicrobial peptide

decreases expression
increases expression

Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA

PMID:25633564 PMID:28284560

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

HMG-box transcription factor 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]
Niclosamide results in increased expression of HBP1 mRNA

PMID:27542212 PMID:36318118

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

histone deacetylase 5

increases expression

Niclosamide results in increased expression of HDAC5 mRNA

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

helicase with zinc finger 2

increases expression

Niclosamide results in increased expression of HELZ2 mRNA

NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions

Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]

PMID:19160421 PMID:28318631 PMID:32961231

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]

PMID:27542212 PMID:28318631

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide results in increased expression of HEY2 mRNA
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]

PMID:19160421 PMID:28318631

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

HHIP-like 1

increases expression

Niclosamide results in increased expression of HHIPL1 mRNA

NCBI chr 6:127,219,616...127,243,839
Ensembl chr 6:127,220,014...127,242,564

G

HID1 domain containing

increases expression

Niclosamide results in increased expression of HID1 mRNA

NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

PMID:30779072 PMID:36318118

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

homeodomain interacting protein kinase 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

G

histone cluster 1, H2bc

increases expression

Niclosamide results in increased expression of H2BC21 mRNA

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

HIVEP zinc finger 2

increases expression

Niclosamide results in increased expression of HIVEP2 mRNA

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

hexokinase 3

decreases expression

Niclosamide results in decreased expression of HK3 mRNA

NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863

G

3-hydroxy-3-methylglutaryl-CoA lyase

increases expression

Niclosamide results in increased expression of HMGCL mRNA

NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068

G

hyaluronan-mediated motility receptor

decreases expression

Niclosamide results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

H6 family homeobox 2

increases expression

Niclosamide results in increased expression of HMX2 mRNA

NCBI chr 1:186,319,110...186,326,771
Ensembl chr 1:186,319,110...186,326,771

G

4-hydroxy-2-oxoglutarate aldolase 1

increases expression

Niclosamide results in increased expression of HOGA1 mRNA

NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568

G

homer scaffold protein 1

decreases expression

Niclosamide results in decreased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

homer scaffold protein 3

increases expression

Niclosamide results in increased expression of HOMER3 mRNA

NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680

G

homeobox A1

increases expression

Niclosamide results in increased expression of HOXA1

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

G

HR, lysine demethylase and nuclear receptor corepressor

increases expression

Niclosamide results in increased expression of HR mRNA

NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313

G

histamine receptor H 1

increases expression

Niclosamide results in increased expression of HRH1 mRNA

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

heparan sulfate 6-O-sulfotransferase 1

decreases expression

Niclosamide results in decreased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

G

hydroxysteroid (17-beta) dehydrogenase 14

increases expression

Niclosamide results in increased expression of HSD17B14 mRNA

NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases expression

Niclosamide results in increased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression

Niclosamide results in increased expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

Niclosamide results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family B (small) member 7

increases expression

Niclosamide results in increased expression of HSPB7 mRNA

NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266

G

hydrogen voltage-gated channel 1

increases expression

Niclosamide results in increased expression of HVCN1 mRNA

NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141

G

intercellular adhesion molecule 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

intercellular adhesion molecule 5

increases expression

Niclosamide results in increased expression of ICAM5 mRNA

NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588

G

inhibitor of DNA binding 1

increases expression

Niclosamide results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

immediate early response 5-like

increases expression

Niclosamide results in increased expression of IER5L mRNA

NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647

G

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Niclosamide

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 4

increases expression

Niclosamide results in increased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects localization

Niclosamide affects the localization of IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects localization

Niclosamide affects the localization of IKBKG protein

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

IKAROS family zinc finger 2

increases expression

Niclosamide results in increased expression of IKZF2 mRNA

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 12A

multiple interactions

Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 17 receptor E

increases expression

Niclosamide results in increased expression of IL17RE mRNA

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 1 beta

multiple interactions

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 21

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 6

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]

PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

InaF-motif containing 1

increases expression

Niclosamide results in increased expression of INAFM1 mRNA

NCBI chr 1:76,976,808...76,978,292

G

inhibitor of CDK, cyclin A1 interacting protein 1

increases expression

Niclosamide results in increased expression of INCA1 mRNA

NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114

G

inhibin subunit beta E

increases expression

Niclosamide results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

inositol polyphosphate-5-phosphatase J

increases expression

Niclosamide results in increased expression of INPP5J mRNA

NCBI chr14:78,374,161...78,385,305
Ensembl chr14:78,374,161...78,385,326

G

insulin receptor-related receptor

decreases expression

Niclosamide results in decreased expression of INSRR mRNA

NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800

G

IQ motif and Sec7 domain ArfGEF 3

increases expression

Niclosamide results in increased expression of IQSEC3 mRNA

NCBI chr 4:154,610,933...154,707,310
Ensembl chr 4:154,610,934...154,707,310

G

interleukin-1 receptor-associated kinase 2

increases expression

Niclosamide results in increased expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

interferon regulatory factor 2 binding protein 2

increases expression

Niclosamide results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

integrin subunit alpha V

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 3

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]

PMID:26792726 PMID:28824321

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

jade family PHD finger 2

increases expression

Niclosamide results in increased expression of JADE2 mRNA

NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984

G

Janus kinase 3

increases expression

Niclosamide results in increased expression of JAK3 mRNA

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

janus kinase and microtubule interacting protein 3

increases expression

Niclosamide results in increased expression of JAKMIP3 mRNA

NCBI chr 1:193,753,134...193,881,105
Ensembl chr 1:193,811,513...193,881,104

G

Jun dimerization protein 2

increases expression

Niclosamide results in increased expression of JDP2 mRNA

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

junctophilin 3

increases expression

Niclosamide results in increased expression of JPH3 mRNA

NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338

G

junctophilin 4

increases expression

Niclosamide results in increased expression of JPH4 mRNA

NCBI chr15:28,579,579...28,588,903
Ensembl chr15:28,571,568...28,587,573

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects localization
increases expression
increases phosphorylation
multiple interactions

Niclosamide affects the localization of JUN protein
Niclosamide results in increased expression of JUN mRNA
Niclosamide results in increased phosphorylation of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]

PMID:24750999 PMID:27338550

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kelch repeat and BTB domain containing 11

increases expression

Niclosamide results in increased expression of KBTBD11 mRNA

NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736

G

potassium voltage-gated channel modifier subfamily F member 1

increases expression

Niclosamide results in increased expression of KCNF1 mRNA

NCBI chr 6:39,962,301...39,964,979
Ensembl chr 6:39,962,307...39,964,979

G

potassium two pore domain channel subfamily K member 13

decreases expression

Niclosamide results in decreased expression of KCNK13 mRNA

NCBI chr 6:119,240,825...119,345,292
Ensembl chr 6:119,242,188...119,345,240

G

potassium calcium-activated channel subfamily N member 3

increases expression

Niclosamide results in increased expression of KCNN3 mRNA

NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145

G

potassium voltage-gated channel modifier subfamily V member 1

decreases expression

Niclosamide results in decreased expression of KCNV1 mRNA

NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170

G

potassium channel tetramerization domain containing 11

increases expression

Niclosamide results in increased expression of KCTD11 mRNA

NCBI chr10:54,602,575...54,604,738
Ensembl chr10:54,599,754...54,604,760

G

KDEL endoplasmic reticulum protein retention receptor 3

increases expression

Niclosamide results in increased expression of KDELR3 mRNA

NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600

G

lysine demethylase 5B

increases expression

Niclosamide results in increased expression of KDM5B mRNA

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

lysine demethylase 6B

increases expression

Niclosamide results in increased expression of KDM6B mRNA

NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794

G

lysine demethylase 7A

increases expression

Niclosamide results in increased expression of KDM7A mRNA

NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998

G

KH and NYN domain containing

increases expression

Niclosamide results in increased expression of KHNYN mRNA

NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967

G

KIAA1614 homolog

decreases expression

Niclosamide results in decreased expression of KIAA1614 mRNA

NCBI chr13:67,388,916...67,427,392
Ensembl chr13:67,389,044...67,421,272

G

kinesin family member 11

decreases expression

Niclosamide results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 20A

decreases expression

Niclosamide results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member C1

decreases expression

Niclosamide results in decreased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

G

kirre like nephrin family adhesion molecule 2

increases expression

Niclosamide results in increased expression of KIRREL2 mRNA

NCBI chr 1:85,708,793...85,718,670
Ensembl chr 1:85,708,793...85,718,670

G

kizuna centrosomal protein

increases expression

Niclosamide results in increased expression of KIZ mRNA

NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190

G

kinesin light chain 4

increases expression

Niclosamide results in increased expression of KLC4 mRNA

NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066

G

KLF transcription factor 15

increases expression

Niclosamide results in increased expression of KLF15 mRNA

NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374

G

KLF transcription factor 9

increases expression

Niclosamide results in increased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch domain containing 8A

increases expression

Niclosamide results in increased expression of KLHDC8A mRNA

NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277

G

kelch domain containing 8B

increases expression

Niclosamide results in increased expression of KLHDC8B mRNA

NCBI chr 8:109,141,594...109,146,584
Ensembl chr 8:109,141,594...109,146,918

G

kelch-like family member 24

increases expression

Niclosamide results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

kelch-like family member 30

increases expression

Niclosamide results in increased expression of KLHL30 mRNA

NCBI chr 9:91,942,475...91,952,756
Ensembl chr 9:91,942,504...91,952,730

G

kelch-like family member 34

decreases expression

Niclosamide results in decreased expression of KLHL34 mRNA

NCBI chr X:37,151,298...37,154,053
Ensembl chr X:37,151,592...37,153,529

G

kallikrein 1-related peptidase C10

decreases expression
multiple interactions

Niclosamide results in decreased expression of KLK3 mRNA; Niclosamide results in decreased expression of KLK3 protein
[Niclosamide co-treated with bicalutamide] results in decreased expression of KLK3 mRNA; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]

PMID:24740322 PMID:25970160 PMID:28500234

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

La ribonucleoprotein 6, translational regulator

increases expression

Niclosamide results in increased expression of LARP6 mRNA

NCBI chr 8:61,183,744...61,205,548
Ensembl chr 8:61,184,116...61,205,535

G

LBH regulator of WNT signaling pathway

increases expression

Niclosamide results in increased expression of LBH mRNA

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

G

ladybird homeobox 2

increases expression

Niclosamide results in increased expression of LBX2 mRNA

NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132

G

lecithin cholesterol acyltransferase

increases expression

Niclosamide results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

leucine carboxyl methyltransferase 2

decreases expression

Niclosamide results in decreased expression of LCMT2 mRNA

NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084

G

ligand dependent nuclear receptor corepressor-like

increases expression

Niclosamide results in increased expression of LCORL mRNA

NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174

G

lactate dehydrogenase A

increases expression
multiple interactions
decreases expression

Niclosamide results in increased expression of LDHA mRNA
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of LDHA mRNA]
Niclosamide results in decreased expression of LDHA mRNA

PMID:22576131 PMID:36318118

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leukocyte receptor cluster member 9

increases expression

Niclosamide results in increased expression of LENG9 mRNA

NCBI chr 1:70,039,099...70,041,559
Ensembl chr 1:70,035,791...70,044,509

G

galectin 3

increases expression

Niclosamide results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

galectin 8

decreases expression

Niclosamide results in decreased expression of LGALS8 mRNA

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

increases expression

Niclosamide results in increased expression of LHPP mRNA

NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578

G

LIM homeobox 6

increases expression

Niclosamide results in increased expression of LHX6 mRNA

NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061

G

leucine rich repeat and Ig domain containing 1

increases expression

Niclosamide results in increased expression of LINGO1 mRNA

NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544

G

lipase G, endothelial type

decreases expression

Niclosamide results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

limb and CNS expressed 1

decreases expression

Niclosamide results in decreased expression of LIX1 mRNA

NCBI chr 1:58,128,961...58,187,554
Ensembl chr 1:58,128,961...58,185,964

G

lemur tyrosine kinase 3

increases expression

Niclosamide results in increased expression of LMTK3 mRNA

NCBI chr 1:96,261,058...96,280,362
Ensembl chr 1:96,260,977...96,280,672

G

LON peptidase N-terminal domain and ring finger 1

increases expression

Niclosamide results in increased expression of LONRF1 mRNA

NCBI chr16:55,984,572...56,015,156
Ensembl chr16:55,984,463...56,015,156

G

lysyl oxidase-like 3

increases expression

Niclosamide results in increased expression of LOXL3 mRNA

NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466

G

lipin 3

increases expression

Niclosamide results in increased expression of LPIN3 mRNA

NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327

G

LDL receptor related protein 1

increases expression

Niclosamide results in increased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

LDL receptor related protein 10

increases expression

Niclosamide results in increased expression of LRP10 mRNA

NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505

G

LDL receptor related protein 5

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]]

NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581

G

LDL receptor related protein 6

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]

PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231

NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497

G

leucine rich repeat containing 2

increases expression

Niclosamide results in increased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

leucine rich repeat containing 55

decreases expression

Niclosamide results in decreased expression of LRRC55 mRNA

NCBI chr 3:70,269,908...70,280,651
Ensembl chr 3:70,265,936...70,278,639

G

leucine rich repeat containing 73

increases expression

Niclosamide results in increased expression of LRRC73 mRNA

NCBI chr 9:14,726,157...14,730,144
Ensembl chr 9:14,726,158...14,729,158

G

leucine rich repeat containing 75B

increases expression

Niclosamide results in increased expression of LRRC75B mRNA

NCBI chr20:13,100,302...13,106,503
Ensembl chr20:13,100,302...13,106,503

G

lymphocyte-specific protein 1

decreases expression

Niclosamide results in decreased expression of LSP1 mRNA

NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416

G

latent transforming growth factor beta binding protein 4

increases expression

Niclosamide results in increased expression of LTBP4 mRNA

NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178

G

lymphocyte antigen 6 family member G5B

decreases expression

Niclosamide results in decreased expression of LY6G5B mRNA

NCBI chr20:3,705,464...3,707,830
Ensembl chr20:3,706,124...3,707,133

G

LYR motif containing 9

increases expression

Niclosamide results in increased expression of LYRM9 mRNA

NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772

G

MET transcriptional regulator MACC1

multiple interactions

Niclosamide inhibits the reaction [MACC1 protein results in increased expression of S100A4 protein]

NCBI chr 6:140,352,690...140,430,255
Ensembl chr 6:140,352,755...140,430,255

G

mitotic arrest deficient 2 like 1

decreases expression

Niclosamide results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAGI family member, X-linked

increases expression

Niclosamide results in increased expression of MAGIX mRNA

NCBI chr X:14,824,114...14,832,466
Ensembl chr X:14,824,188...14,831,045

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microtubule-associated protein 1 light chain 3 beta

increases expression

Niclosamide results in increased expression of MAP1LC3B protein modified form

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

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mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

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mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

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mitogen-activated protein kinase 8

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

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mitogen-activated protein kinase 9

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

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microtubule-associated protein tau

increases expression

Niclosamide results in increased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

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MBL associated serine protease 1

increases expression

Niclosamide results in increased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

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microtubule associated serine/threonine kinase 1

increases expression

Niclosamide results in increased expression of MAST1 mRNA

NCBI chr19:23,216,418...23,244,224
Ensembl chr19:23,207,991...23,244,235

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methionine adenosyltransferase 2A

decreases expression

Niclosamide results in decreased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

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matrilin 1

increases expression

Niclosamide results in increased expression of MATN1 mRNA

NCBI chr 5:143,117,198...143,127,140
Ensembl chr 5:143,117,504...143,127,059

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membrane bound O-acyltransferase domain containing 7

increases expression

Niclosamide results in increased expression of MBOAT7 mRNA

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

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MCL1 apoptosis regulator, BCL2 family member

decreases expression

Niclosamide results in decreased expression of MCL1 protein

PMID:20215516 PMID:26116531

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

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minichromosome maintenance 10 replication initiation factor

decreases expression

Niclosamide results in decreased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

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minichromosome maintenance complex component 2

decreases expression

Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein

PMID:28284560 PMID:29031202

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

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minichromosome maintenance complex component 5

decreases expression

Niclosamide results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

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minichromosome maintenance complex component 6

decreases expression

Niclosamide results in decreased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

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minichromosome maintenance complex component 7

decreases expression

Niclosamide results in decreased expression of MCM7 protein

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

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malic enzyme 3

decreases expression

Niclosamide results in decreased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

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mediator complex subunit 31

decreases expression

Niclosamide results in decreased expression of MED31 mRNA

NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326

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myocyte enhancer factor 2D

increases expression

Niclosamide results in increased expression of MEF2D mRNA

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

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Meis homeobox 3

increases expression

Niclosamide results in increased expression of MEIS3 mRNA

NCBI chr 1:76,861,267...76,872,691
Ensembl chr 1:76,861,924...76,872,691

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