CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: stilben-4-ol
Accession: CHEBI:36664
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Definition: A phenol having the structure of stilbene with a hydroxy function at C-4 of one of the phenyl rings; the stereochemistry across the alkene bond is not specified.
Synonyms: exact_synonym: 4-(2-phenylethenyl)phenol
related_synonym: 4-(2-phenylvinyl)phenol; 4-hydroxystilbene; Formula=C14H12O; InChI=1S/C14H12O/c15-14-10-8-13(9-11-14)7-6-12-4-2-1-3-5-12/h1-11,15H; InChIKey=QVLMUEOXQBUPAH-UHFFFAOYSA-N; SMILES=[H]C(=C([H])c1ccc(O)cc1)c1ccccc1
xref: Beilstein:2208345; CAS:3839-46-1; Gmelin:1405160
xref_mesh: MESH:C064297
G
Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein]
CTD
PMID:22865646
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
4-hydroxystilbene results in increased expression of ADIPOQ mRNA
CTD
PMID:23748787
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Ar
androgen receptor
affects binding
EXP
4-hydroxystilbene binds to AR protein
CTD
PMID:14565775
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Ccna2
cyclin A2
increases expression
ISO
4-hydroxystilbene results in increased expression of CCNA2 mRNA
CTD
PMID:19496085
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ctsd
cathepsin D
increases expression
ISO
4-hydroxystilbene results in increased expression of CTSD mRNA
CTD
PMID:19496085
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Esr1
estrogen receptor 1
multiple interactions
ISO
4-hydroxystilbene analog binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [4-hydroxystilbene analog binds to and results in increased activity of ESR1 protein]
CTD
PMID:19496085
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
4-hydroxystilbene results in increased expression of FOS mRNA
CTD
PMID:19496085
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Pgr
progesterone receptor
increases expression
ISO
4-hydroxystilbene results in increased expression of PGR mRNA
CTD
PMID:19496085
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
ISO
4-hydroxystilbene results in decreased expression of PPARG mRNA
CTD
PMID:23748787
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Retn
resistin
decreases expression
ISO
4-hydroxystilbene results in decreased expression of RETN mRNA
CTD
PMID:23748787
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
G
Slc22a12
solute carrier family 22 member 12
multiple interactions
ISO
4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]
CTD
PMID:22865646
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
G
Umod
uromodulin
multiple interactions
ISO
4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein]
CTD
PMID:22865646
NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
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