1,8-naphthyridine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1,8-naphthyridine	go back to main search page
Accession:	CHEBI:36628	browse the term
Definition:	A naphthyridine in which the nitrogens are situated at positions 1 and 8.
Synonyms:	related_synonym:	1,8-diazanaphthalene; 1,8-pyridopyridine; Formula=C8H6N2; InChI=1S/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H; InChIKey=FLBAYUMRQUHISI-UHFFFAOYSA-N; SMILES=c1cnc2ncccc2c1; napy
	xref:	CAS:254-60-4; Gmelin:27124; Reaxys:109347

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Genes (1914)

enoxacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity
affects binding

Enoxacin inhibits the reaction [CYP1A2 protein affects the metabolism of Fluvoxamine]; Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]
Enoxacin results in decreased activity of CYP1A2 protein
Enoxacin binds to CYP1A2 protein
Enoxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]

PMID:7946932 PMID:8905919 PMID:15905806

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

glutathione S-transferase pi 1

multiple interactions

Enoxacin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

potassium voltage-gated channel subfamily H member 2

affects binding

Enoxacin binds to KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008

G

nitric oxide synthase 1

multiple interactions

7-nitroindazole inhibits the reaction [[Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein]; [Enoxacin co-treated with fenbufen] results in increased activity of NOS1 protein

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

nalidixic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

multiple interactions

Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

matrix metallopeptidase 13

multiple interactions
decreases expression

Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Nalidixic Acid results in decreased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239

trovafloxacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:38,999,163...39,021,147

G

alanyl-tRNA synthetase domain containing 1

decreases expression

trovafloxacin results in decreased expression of AARSD1 mRNA

NCBI chr10:86,840,874...86,854,077
Ensembl chr10:86,340,626...86,353,729

G

apoptosis-associated tyrosine kinase

decreases expression

trovafloxacin results in decreased expression of AATK mRNA

NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,291,585...105,327,112

G

ATP binding cassette subfamily A member 2

decreases expression

trovafloxacin results in decreased expression of ABCA2 mRNA

NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537

G

ATP binding cassette subfamily A member 5

decreases expression

trovafloxacin results in decreased expression of ABCA5 mRNA

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,240,154...95,308,976

G

ATP binding cassette subfamily A member 7

decreases expression

trovafloxacin results in decreased expression of ABCA7 mRNA

NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425

G

ATP binding cassette subfamily A member 8

decreases expression

trovafloxacin results in decreased expression of ABCA8B mRNA

NCBI chr10:95,416,984...95,490,647
Ensembl chr10:94,917,520...94,990,988

G

ATP binding cassette subfamily B member 7

decreases expression

trovafloxacin results in decreased expression of ABCB7 mRNA

NCBI chr X:73,361,296...73,502,464
Ensembl chr X:69,295,552...69,436,858

G

ATP binding cassette subfamily D member 2

decreases expression

trovafloxacin results in decreased expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:122,263,032...122,311,642

G

abhydrolase domain containing 15

decreases expression

trovafloxacin results in decreased expression of ABHD15 mRNA

NCBI chr10:62,861,335...62,866,726
Ensembl chr10:62,363,209...62,368,600

G

acetyl-CoA carboxylase alpha

decreases expression

trovafloxacin results in decreased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

decreases expression

trovafloxacin results in decreased expression of ACAP1 mRNA

NCBI chr10:55,104,040...55,119,280
Ensembl chr10:54,605,323...54,619,472

G

atypical chemokine receptor 4

increases expression

trovafloxacin results in increased expression of ACKR4 mRNA

NCBI chr 8:113,595,325...113,599,762
Ensembl chr 8:104,716,067...104,723,617

G

acyl-CoA thioesterase 3

decreases expression

trovafloxacin results in decreased expression of ACOT3 mRNA

NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA thioesterase 4

decreases expression

trovafloxacin results in decreased expression of ACOT4 mRNA

NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:103,668,753...103,673,917

G

acrosin binding protein

increases expression

trovafloxacin results in increased expression of ACRBP mRNA

NCBI chr 4:159,537,395...159,550,454
Ensembl chr 4:157,841,841...157,864,213

G

acyl-CoA synthetase family member 2

decreases expression

trovafloxacin results in decreased expression of ACSF2 mRNA

NCBI chr10:80,001,389...80,043,796
Ensembl chr10:79,504,511...79,546,673

G

acyl-CoA synthetase family member 3

decreases expression

trovafloxacin results in decreased expression of ACSF3 mRNA

NCBI chr19:67,743,660...67,784,109
Ensembl chr19:50,835,221...50,875,553

G

acyl-CoA synthetase short-chain family member 1

decreases expression

trovafloxacin results in decreased expression of ACSS1 mRNA

NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:139,450,383...139,500,325

G

acyl-CoA synthetase short-chain family member 2

decreases expression

trovafloxacin results in decreased expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:144,004,336...144,059,675

G

actin, beta

decreases expression

trovafloxacin results in decreased expression of ACTB mRNA

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

actin, gamma 1

decreases expression

trovafloxacin results in decreased expression of ACTG1 mRNA

NCBI chr10:106,118,106...106,120,951
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232

G

actin related protein 3B

decreases expression

trovafloxacin results in decreased expression of ACTR3B mRNA

NCBI chr 4:9,995,553...10,089,422
Ensembl chr 4:9,262,233...9,355,441

G

activin A receptor like type 1

increases expression

trovafloxacin results in increased expression of ACVRL1 mRNA

NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:132,239,729...132,256,591

G

aminoacylase 1

decreases expression

trovafloxacin results in decreased expression of ACY1 mRNA

NCBI chr 8:115,951,068...115,956,471
Ensembl chr 8:107,072,358...107,077,682

G

ADAM metallopeptidase domain 1a

increases expression

trovafloxacin results in increased expression of ADAM1A mRNA

NCBI chr12:40,674,460...40,680,988
Ensembl chr12:35,017,315...35,020,311

G

ADAM metallopeptidase domain 22

increases expression

trovafloxacin results in increased expression of ADAM22 mRNA

NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:25,715,990...25,964,962

G

ADAM metallopeptidase domain 33

increases expression

trovafloxacin results in increased expression of ADAM33 mRNA

NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:118,271,029...118,283,461

G

ADAM metallopeptidase domain 3A

decreases expression

trovafloxacin results in decreased expression of ADAM3 mRNA

NCBI chr16:74,002,566...74,052,579
Ensembl chr16:67,299,949...67,349,968

G

ADAM metallopeptidase domain 8

increases expression

trovafloxacin results in increased expression of ADAM8 mRNA

NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase with thrombospondin type 1 motif, 4

decreases expression

trovafloxacin results in decreased expression of ADAMTS4 mRNA

NCBI chr13:86,203,011...86,212,500
Ensembl chr13:83,670,183...83,680,065

G

ArfGAP with dual PH domains 2

increases expression
decreases expression

trovafloxacin results in increased expression of ADAP2 mRNA
trovafloxacin results in decreased expression of ADAP2 mRNA

PMID:24136188 PMID:35537566

NCBI chr10:65,635,891...65,665,019
Ensembl chr10:65,138,020...65,165,604

G

adducin 3

decreases expression

trovafloxacin results in decreased expression of ADD3 mRNA

NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor E4

increases expression

trovafloxacin results in increased expression of ADGRE4 mRNA

NCBI chr 9:10,085,258...10,240,346
Ensembl chr 9:9,760,355...9,900,760

G

adhesion G protein-coupled receptor L1

decreases expression

trovafloxacin results in decreased expression of ADGRL1 mRNA

NCBI chr19:41,107,162...41,148,752
Ensembl chr19:24,204,360...24,244,139

G

adhesion G protein-coupled receptor V1

decreases expression

trovafloxacin results in decreased expression of ADGRV1 mRNA

NCBI chr 2:13,067,149...13,647,407
Ensembl chr 2:11,331,442...11,911,688

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

decreases expression

trovafloxacin results in decreased expression of ADH7 mRNA

NCBI chr 2:229,422,125...229,436,584
Ensembl chr 2:226,741,788...226,763,182

G

adiponectin receptor 2

decreases expression

trovafloxacin results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355

G

adrenomedullin

decreases expression

trovafloxacin results in decreased expression of ADM mRNA

NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor alpha 1A

increases expression

trovafloxacin results in increased expression of ADRA1A mRNA

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500

G

adrenoceptor beta 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512

G

apoptosis enhancing nuclease

increases expression

trovafloxacin results in increased expression of AEN mRNA

NCBI chr 1:142,224,499...142,233,902
Ensembl chr 1:132,815,142...132,824,523

G

actin filament associated protein 1-like 1

decreases expression

trovafloxacin results in decreased expression of AFAP1L1 mRNA

NCBI chr18:57,454,120...57,514,584
Ensembl chr18:55,183,786...55,244,146

G

AGBL carboxypeptidase 3

decreases expression

trovafloxacin results in decreased expression of AGBL3 mRNA

NCBI chr 4:64,416,139...64,498,987
Ensembl chr 4:63,453,940...63,531,188

G

AGBL carboxypeptidase 5

decreases expression

trovafloxacin results in decreased expression of AGBL5 mRNA

NCBI chr 6:31,192,281...31,213,494
Ensembl chr 6:25,472,333...25,490,738

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

decreases expression

trovafloxacin results in decreased expression of AGL mRNA

NCBI chr 2:207,389,949...207,445,959
Ensembl chr 2:204,705,053...204,760,828

G

alkylglycerol monooxygenase

decreases expression

trovafloxacin results in decreased expression of AGMO mRNA

NCBI chr 6:59,713,495...60,044,851
Ensembl chr 6:53,986,292...54,317,623

G

ATP/GTP binding carboxypeptidase 1

decreases expression

trovafloxacin results in decreased expression of AGTPBP1 mRNA

NCBI chr17:5,092,108...5,244,414
Ensembl chr17:5,120,609...5,238,869

G

adenosylhomocysteinase-like 1

decreases expression

trovafloxacin results in decreased expression of AHCYL1 mRNA

NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:195,294,153...195,345,815

G

Abelson helper integration site 1

decreases expression

trovafloxacin results in decreased expression of AHI1 mRNA

NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:15,762,462...15,891,041

G

adenylate kinase 1

increases expression

trovafloxacin results in increased expression of AK1 mRNA

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041

G

adenylate kinase 6

increases expression

trovafloxacin results in increased expression of AK6 mRNA

NCBI chr 2:33,528,388...33,540,445
Ensembl chr 2:31,794,519...31,806,371
Ensembl chr20:31,794,519...31,806,371

G

A-kinase anchoring protein 7

decreases expression

trovafloxacin results in decreased expression of AKAP7 mRNA

NCBI chr 1:21,906,503...22,168,663
Ensembl chr 1:20,087,373...20,217,797

G

AT-hook transcription factor

decreases expression

trovafloxacin results in decreased expression of AKNA mRNA

NCBI chr 5:81,792,928...81,839,936
Ensembl chr 5:76,777,415...76,816,017

G

aldo-keto reductase family 1, member B7

decreases expression

trovafloxacin results in decreased expression of AKR1B7 mRNA

NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:63,076,800...63,089,502

G

aldo-keto reductase family 7 member A3

decreases expression

trovafloxacin results in decreased expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

trovafloxacin results in increased phosphorylation of AKT1 protein
TNF protein promotes the reaction [trovafloxacin results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 16 family, member A1

decreases expression

trovafloxacin results in decreased expression of ALDH16A1 mRNA

NCBI chr 1:104,763,200...104,776,270
Ensembl chr 1:95,613,558...95,640,131

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

trovafloxacin results in decreased expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

trovafloxacin results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

decreases expression

trovafloxacin results in decreased expression of ALDH1B1 mRNA

NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 1 family, member L2

decreases expression

trovafloxacin results in decreased expression of ALDH1L2 mRNA

NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776

G

alkB homolog 4, lysine demethylase

increases expression

trovafloxacin results in increased expression of ALKBH4 mRNA

NCBI chr12:26,160,643...26,166,560
Ensembl chr12:20,524,030...20,529,947

G

ALMS1, centrosome and basal body associated protein

decreases expression

trovafloxacin results in decreased expression of ALMS1 mRNA

NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005

G

alpha-methylacyl-CoA racemase

decreases expression

trovafloxacin results in decreased expression of AMACR mRNA

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:59,946,153...59,958,255

G

adenosylmethionine decarboxylase 1

decreases expression

trovafloxacin results in decreased expression of AMD1 mRNA

NCBI chr20:45,250,289...45,324,939
Ensembl chr20:43,697,237...43,711,476

G

amidohydrolase domain containing 2

decreases expression

trovafloxacin results in decreased expression of AMDHD2 mRNA

NCBI chr10:13,692,136...13,700,632
Ensembl chr10:13,187,578...13,196,095

G

anti-Mullerian hormone

increases expression

trovafloxacin results in increased expression of AMH mRNA

NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:8,906,836...8,909,282

G

adhesion molecule with Ig like domain 3

increases expression

trovafloxacin results in increased expression of AMIGO3 mRNA

NCBI chr 8:117,620,499...117,622,025
Ensembl chr 8:108,693,060...108,744,555

G

AMMECR1 like

increases expression

trovafloxacin results in increased expression of AMMECR1L mRNA

NCBI chr18:23,386,114...23,411,177
Ensembl chr18:23,386,903...23,410,920

G

angiomotin-like 1

decreases expression

trovafloxacin results in decreased expression of AMOTL1 mRNA

NCBI chr 8:19,630,139...19,749,027
Ensembl chr 8:11,353,674...11,467,573

G

angiomotin like 2

decreases expression

trovafloxacin results in decreased expression of AMOTL2 mRNA

NCBI chr 8:112,182,060...112,198,032
Ensembl chr 8:103,302,992...103,318,910

G

archaelysin family metallopeptidase 1

decreases expression

trovafloxacin results in decreased expression of AMZ1 mRNA

NCBI chr12:19,000,448...19,038,625
Ensembl chr12:13,891,123...13,909,783

G

anaphase promoting complex subunit 1

decreases expression

trovafloxacin results in decreased expression of ANAPC1 mRNA

NCBI chr 3:136,303,350...136,383,464
Ensembl chr 3:115,850,185...115,930,273

G

anaphase-promoting complex subunit 5

decreases expression

trovafloxacin results in decreased expression of ANAPC5 mRNA

NCBI chr12:39,409,519...39,442,518
Ensembl chr12:33,748,735...33,781,781

G

angiogenin

decreases expression

trovafloxacin results in decreased expression of ANG mRNA

NCBI chr15:26,786,233...26,796,883

G

angel homolog 1

decreases expression

trovafloxacin results in decreased expression of ANGEL1 mRNA

NCBI chr 6:112,080,074...112,117,178
Ensembl chr 6:106,349,126...106,386,209

G

angel homolog 2

decreases expression

trovafloxacin results in decreased expression of ANGEL2 mRNA

NCBI chr13:105,041,727...105,060,640
Ensembl chr13:102,510,589...102,529,493

G

angiopoietin-like 3

increases expression

trovafloxacin results in increased expression of ANGPTL3 mRNA

NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:113,703,012...113,709,957

G

angiopoietin-like 4

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519

G

angiopoietin-like 6

decreases expression

trovafloxacin results in decreased expression of ANGPTL6 mRNA

NCBI chr 8:27,689,804...27,696,172
Ensembl chr 8:19,413,619...19,419,925

G

ankyrin repeat and LEM domain containing 1

decreases expression

trovafloxacin results in decreased expression of ANKLE1 mRNA

NCBI chr16:18,109,865...18,116,999
Ensembl chr16:18,076,492...18,083,729

G

ankyrin repeat domain 23

increases expression

trovafloxacin results in increased expression of ANKRD23 mRNA

NCBI chr 9:46,269,107...46,274,578
Ensembl chr 9:38,773,240...38,779,839

G

ankyrin repeat domain 55

decreases expression

trovafloxacin results in decreased expression of ANKRD55 mRNA

NCBI chr 2:45,617,011...45,717,086
Ensembl chr 2:43,883,857...43,983,680

G

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

decreases expression

trovafloxacin results in decreased expression of ANKZF1 mRNA

NCBI chr 9:84,136,862...84,143,830
Ensembl chr 9:76,688,194...76,696,469

G

anillin, actin binding protein

decreases expression

trovafloxacin results in decreased expression of ANLN mRNA

NCBI chr 8:29,134,222...29,197,513
Ensembl chr 8:20,858,228...20,921,538

G

anoctamin 7

increases expression

trovafloxacin results in increased expression of ANO7 mRNA

NCBI chr 9:101,364,915...101,392,711
Ensembl chr 9:93,917,524...93,945,323

G

adenine nucleotide translocase lysine methyltransferase

decreases expression

trovafloxacin results in decreased expression of FAM173A mRNA

NCBI chr10:15,316,797...15,320,950
Ensembl chr10:14,812,269...14,814,193

G

ANTXR cell adhesion molecule 2

increases expression

trovafloxacin results in increased expression of ANTXR2 mRNA

NCBI chr14:11,845,774...11,986,166
Ensembl chr14:11,541,772...11,682,094

G

annexin A9

decreases expression

trovafloxacin results in decreased expression of ANXA9 mRNA

NCBI chr 2:185,562,174...185,572,560
Ensembl chr 2:182,872,929...182,883,374

G

adaptor related protein complex 1 subunit gamma 2

decreases expression

trovafloxacin results in decreased expression of AP1G2 mRNA

NCBI chr15:32,541,528...32,549,392
Ensembl chr15:28,571,568...28,589,004

G

adaptor related protein complex 1 subunit sigma 1

decreases expression

trovafloxacin results in decreased expression of AP1S1 mRNA

NCBI chr12:25,261,958...25,272,483
Ensembl chr12:19,625,332...19,756,713

G

adaptor related protein complex 5 subunit zeta 1

decreases expression

trovafloxacin results in decreased expression of AP5Z1 mRNA

NCBI chr12:17,207,315...17,222,975
Ensembl chr12:12,093,834...12,108,511

G

amyloid beta precursor protein binding family B member 3

increases expression

trovafloxacin results in increased expression of APBB3 mRNA

NCBI chr18:28,547,205...28,554,383
Ensembl chr18:28,270,545...28,280,094

G

APC regulator of WNT signaling pathway 2

increases expression

trovafloxacin results in increased expression of APC2 mRNA

NCBI chr 7:10,043,010...10,065,037
Ensembl chr 7:9,392,336...9,414,310

G

acylaminoacyl-peptide hydrolase

decreases expression

trovafloxacin results in decreased expression of APEH mRNA

NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:108,773,794...108,782,933

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

apurinic/apyrimidinic endodeoxyribonuclease 2

increases expression

trovafloxacin results in increased expression of APEX2 mRNA

NCBI chr X:22,914,943...22,937,713
Ensembl chr X:19,487,419...19,508,439

G

apolipoprotein A5

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of APOA5 mRNA

NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:46,561,229...46,563,816

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apolipoprotein E

increases expression

trovafloxacin results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 9

decreases expression

trovafloxacin results in decreased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395

G

ADP-ribosylation factor 2

increases expression

trovafloxacin results in increased expression of ARF2 mRNA

NCBI chr10:89,367,843...89,389,644
Ensembl chr10:88,867,836...88,889,659

G

Rho GTPase activating protein 19

decreases expression

trovafloxacin results in decreased expression of ARHGAP19 mRNA

NCBI chr 1:250,519,703...250,566,705
Ensembl chr 1:240,580,871...240,617,287

G

Rho GTPase activating protein 24

decreases expression

trovafloxacin results in decreased expression of ARHGAP24 mRNA

NCBI chr14:7,105,200...7,488,437
Ensembl chr14:6,800,631...7,183,823

G

Rho GTPase activating protein 26

decreases expression

trovafloxacin results in decreased expression of ARHGAP26 mRNA

NCBI chr18:30,702,602...31,489,047
Ensembl chr18:30,838,671...31,235,194

G

Rho GTPase activating protein 33

decreases expression

trovafloxacin results in decreased expression of ARHGAP33 mRNA

NCBI chr 1:94,903,566...94,917,074
Ensembl chr 1:85,776,108...85,789,678

G

Rho GTPase activating protein 6

decreases expression

trovafloxacin results in decreased expression of ARHGAP6 mRNA

NCBI chr X:28,525,912...29,062,344
Ensembl chr X:24,953,464...25,488,663

G

Rho guanine nucleotide exchange factor 17

decreases expression

trovafloxacin results in decreased expression of ARHGEF17 mRNA

NCBI chr 1:164,642,690...164,702,241
Ensembl chr 1:155,233,168...155,290,498

G

Rho guanine nucleotide exchange factor 3

decreases expression

trovafloxacin results in decreased expression of ARHGEF3 mRNA

NCBI chr16:2,308,311...2,588,634
Ensembl chr16:2,300,138...2,581,945

G

Rho guanine nucleotide exchange factor 39

decreases expression

trovafloxacin results in decreased expression of ARHGEF39 mRNA

NCBI chr 5:62,548,300...62,551,870
Ensembl chr 5:57,752,509...57,756,109

G

AT-rich interaction domain 5A

decreases expression

trovafloxacin results in decreased expression of ARID5A mRNA

NCBI chr 9:46,030,513...46,058,729
Ensembl chr 9:38,534,590...38,547,597

G

AT-rich interaction domain 5B

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ARID5B mRNA

NCBI chr20:20,305,693...20,489,689
Ensembl chr20:20,307,731...20,487,433

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ARF like GTPase 10

increases expression

trovafloxacin results in increased expression of ARL10 mRNA

NCBI chr17:10,035,320...10,043,732
Ensembl chr17:10,030,213...10,038,703

G

ARF like GTPase 11

decreases expression

trovafloxacin results in decreased expression of ARL11 mRNA

NCBI chr15:39,659,404...39,661,651
Ensembl chr15:35,480,018...35,496,596

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ARF like GTPase 4C

decreases expression

trovafloxacin results in decreased expression of ARL4C mRNA

NCBI chr 9:96,748,075...96,751,510
Ensembl chr 9:89,298,005...89,304,513

G

ARF like GTPase 4D

increases expression

trovafloxacin results in increased expression of ARL4D mRNA

NCBI chr10:87,092,276...87,103,079
Ensembl chr10:86,595,661...86,602,836

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ARF like GTPase 6 interacting protein 5

increases expression

trovafloxacin results in increased expression of ARL6IP5 mRNA

NCBI chr 4:131,365,320...131,395,311
Ensembl chr 4:129,810,645...129,838,608

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armadillo repeat containing 2

decreases expression

trovafloxacin results in decreased expression of ARMC2 mRNA

NCBI chr20:46,976,442...47,083,888
Ensembl chr20:45,394,127...45,504,819

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armadillo repeat containing 7

increases expression

trovafloxacin results in increased expression of ARMC7 mRNA

NCBI chr10:101,222,056...101,238,598
Ensembl chr10:100,723,105...100,739,636

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acidic residue methyltransferase 1

decreases expression

trovafloxacin results in decreased expression of ARMT1 mRNA

NCBI chr 1:43,299,916...43,323,675
Ensembl chr 1:40,894,550...40,918,302

G

arrestin, beta 1

decreases expression

trovafloxacin results in decreased expression of ARRB1 mRNA

NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061

G

arylsulfatase A

decreases expression

trovafloxacin results in decreased expression of ARSA mRNA

NCBI chr 7:122,422,971...122,426,971
Ensembl chr 7:120,543,362...120,548,783

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ARV1 homolog, fatty acid homeostasis modulator

increases expression

trovafloxacin results in increased expression of ARV1 mRNA

NCBI chr19:69,589,728...69,601,547
Ensembl chr19:52,692,337...52,704,156

G

ankyrin repeat and SOCS box-containing 10

decreases expression

trovafloxacin results in decreased expression of ASB10 mRNA

NCBI chr 4:11,522,531...11,531,946
Ensembl chr 4:10,630,448...10,639,060

G

ankyrin repeat and SOCS box-containing 6

increases expression

trovafloxacin results in increased expression of ASB6 mRNA

NCBI chr 3:34,508,390...34,513,033
Ensembl chr 3:14,110,628...14,115,242

G

anti-silencing function 1B histone chaperone

decreases expression

trovafloxacin results in decreased expression of ASF1B mRNA

NCBI chr19:41,085,786...41,100,352
Ensembl chr19:24,181,028...24,195,549

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asparagine synthetase (glutamine-hydrolyzing)

decreases expression

trovafloxacin results in decreased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423

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assembly factor for spindle microtubules

decreases expression

trovafloxacin results in decreased expression of ASPM mRNA

NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755

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ASPSCR1 tether for SLC2A4, UBX domain containing

decreases expression

trovafloxacin results in decreased expression of ASPSCR1 mRNA

NCBI chr10:106,450,600...106,488,231
Ensembl chr10:105,952,227...105,989,904

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asparaginase and isoaspartyl peptidase 1

decreases expression

trovafloxacin results in decreased expression of ASRGL1 mRNA

NCBI chr 1:215,436,180...215,456,188
Ensembl chr 1:206,006,109...206,027,108

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activating transcription factor 2

multiple interactions
increases phosphorylation

pyrazolanthrone inhibits the reaction [trovafloxacin results in increased phosphorylation of ATF2 protein]

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236

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activating transcription factor 4

decreases expression

trovafloxacin results in decreased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

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activating transcription factor 5

decreases expression

trovafloxacin results in decreased expression of ATF5 mRNA

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:95,295,610...95,299,707

G

autophagy related 10

multiple interactions

[trovafloxacin co-treated with TNF protein] results in increased expression of ATG10 mRNA

NCBI chr 2:23,843,695...24,133,459
Ensembl chr 2:22,108,426...22,398,233

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autophagy related 101

increases expression

trovafloxacin results in increased expression of ATG101 mRNA

NCBI chr 7:134,277,223...134,286,387
Ensembl chr 7:132,398,483...132,407,633

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autophagy related 12

increases expression

trovafloxacin results in increased expression of ATG12 mRNA

PMID:33609687 PMID:35537566

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418

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autophagy related 14

increases expression
multiple interactions

trovafloxacin results in increased expression of ATG14 mRNA
TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG14 mRNA]

NCBI chr15:23,275,457...23,306,817
Ensembl chr15:20,795,750...20,827,113

G

autophagy related 16-like 1

increases expression
multiple interactions

trovafloxacin results in increased expression of ATG16L1 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG16L1 mRNA

NCBI chr 9:95,869,839...95,905,354
Ensembl chr 9:88,422,038...88,457,529

G

autophagy related 16-like 2

decreases expression

trovafloxacin results in decreased expression of ATG16L2 mRNA

NCBI chr 1:165,100,946...165,123,307
Ensembl chr 1:155,684,564...155,703,420

G

autophagy related 2A

multiple interactions

[trovafloxacin co-treated with TNF protein] results in increased expression of ATG2A mRNA

NCBI chr 1:212,971,822...212,991,505
Ensembl chr 1:203,542,559...203,562,242

G

autophagy related 2B

increases expression

trovafloxacin results in increased expression of ATG2B mRNA

NCBI chr 6:130,286,979...130,357,109
Ensembl chr 6:124,525,523...124,592,015

G

autophagy related 3

increases expression
multiple interactions

trovafloxacin results in increased expression of ATG3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG3 mRNA

NCBI chr11:69,130,948...69,159,280
Ensembl chr11:55,624,917...55,653,224

G

autophagy related 4A, cysteine peptidase

increases expression
multiple interactions

trovafloxacin results in increased expression of ATG4A mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ATG4A mRNA

NCBI chr X:109,453,712...109,553,758
Ensembl chr X:104,665,345...104,765,268

G

autophagy related 4C, cysteine peptidase

multiple interactions

[trovafloxacin co-treated with TNF protein] results in decreased expression of ATG4C mRNA

NCBI chr 5:118,977,594...119,050,894
Ensembl chr 5:113,867,092...113,934,830

G

autophagy related 5

affects response to substance
increases expression
multiple interactions

ATG5 protein affects the susceptibility to trovafloxacin
trovafloxacin results in increased expression of ATG5 mRNA
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG5 mRNA]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

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autophagy related 9B

increases expression
multiple interactions

trovafloxacin results in increased expression of ATG9B mRNA
TNF protein promotes the reaction [trovafloxacin results in increased expression of ATG9B mRNA]; trovafloxacin promotes the reaction [TNF protein results in increased expression of ATG9B mRNA]

NCBI chr 4:11,678,548...11,686,097
Ensembl chr 4:10,786,114...10,793,651

G

ATM serine/threonine kinase

decreases expression

trovafloxacin results in decreased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

atos homolog B

increases expression

trovafloxacin results in increased expression of ATOSB mRNA

NCBI chr 5:62,056,654...62,070,338
Ensembl chr 5:57,260,841...57,268,892

G

ATPase phospholipid transporting 11C

decreases expression

trovafloxacin results in decreased expression of ATP11C mRNA

NCBI chr X:143,600,763...143,788,407
Ensembl chr X:138,565,836...138,751,204

G

ATPase Na+/K+ transporting subunit alpha 3

decreases expression

trovafloxacin results in decreased expression of ATP1A3 mRNA

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918

G

ATP synthase membrane subunit c locus 3

increases expression

trovafloxacin results in increased expression of ATP5MC3 mRNA

NCBI chr 3:79,218,014...79,220,664
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase membrane subunit e

increases expression

trovafloxacin results in increased expression of ATP5ME mRNA

NCBI chr14:1,464,788...1,465,989
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit K

increases expression

trovafloxacin results in increased expression of ATP5MK mRNA

NCBI chr 1:255,915,255...255,922,185
Ensembl chr 1:245,973,914...245,980,761
Ensembl chr10:245,973,914...245,980,761

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ATPase, H+ transporting V0 subunit e2

decreases expression
increases expression

trovafloxacin results in decreased expression of ATP6V0E2 mRNA
trovafloxacin results in increased expression of ATP6V0E2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 4:78,815,771...78,818,919
Ensembl chr 4:77,482,226...77,488,777

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ATPase phospholipid transporting 8A1

decreases expression

trovafloxacin results in decreased expression of ATP8A1 mRNA

NCBI chr14:40,668,932...40,911,465
Ensembl chr14:40,315,049...40,554,611

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ATR serine/threonine kinase

multiple interactions
decreases expression

4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased phosphorylation of ATR protein]; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein; trovafloxacin results in increased phosphorylation of and results in increased activity of ATR protein; U 0126 inhibits the reaction [trovafloxacin results in increased activity of ATR protein]
trovafloxacin results in decreased expression of ATR mRNA

PMID:25748550 PMID:35537566

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

attractin

increases expression

trovafloxacin results in increased expression of ATRN mRNA

NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:118,110,229...118,244,322

G

ataxin 7-like 3B

increases expression

trovafloxacin results in increased expression of ATXN7L3B mRNA

NCBI chr 7:50,208,666...50,212,190
Ensembl chr 7:48,321,755...48,328,878

G

aurora kinase A and ninein interacting protein

decreases expression

trovafloxacin results in decreased expression of AUNIP mRNA

NCBI chr 5:152,006,021...152,018,614
Ensembl chr 5:146,722,337...146,736,501

G

aurora kinase A

decreases expression

trovafloxacin results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression

trovafloxacin results in decreased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837

G

beta-2 microglobulin

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766

G

beta-1,4-N-acetyl-galactosaminyl transferase 2

decreases expression

trovafloxacin results in decreased expression of B4GALNT2 mRNA

NCBI chr10:81,298,338...81,324,738
Ensembl chr10:80,802,941...80,857,700

G

BAR/IMD domain containing adaptor protein 2 like 1

decreases expression

trovafloxacin results in decreased expression of BAIAP2L1 mRNA

NCBI chr12:15,364,090...15,453,602
Ensembl chr12:10,250,473...10,339,928

G

BRCA1 associated RING domain 1

decreases expression

trovafloxacin results in decreased expression of BARD1 mRNA

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:72,623,155...72,694,265

G

basic leucine zipper ATF-like transcription factor 2

increases expression

trovafloxacin results in increased expression of BATF2 mRNA

NCBI chr 1:212,897,076...212,905,740
Ensembl chr 1:203,468,097...203,475,889

G

Bardet-Biedl syndrome 9

increases expression

trovafloxacin results in increased expression of BBS9 mRNA

NCBI chr 8:29,288,846...29,713,889
Ensembl chr 8:21,013,944...21,437,930

G

BCAR3 adaptor protein, NSP family member

increases expression

trovafloxacin results in increased expression of BCAR3 mRNA

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:210,525,260...210,638,798

G

branched chain amino acid transaminase 1

decreases expression

trovafloxacin results in decreased expression of BCAT1 mRNA

NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:177,964,834...178,046,597

G

BCDIN3 domain containing RNA methyltransferase

decreases expression

trovafloxacin results in decreased expression of BCDIN3D mRNA

NCBI chr 7:132,484,404...132,488,998
Ensembl chr 7:130,605,541...130,610,115

G

beta-carotene oxygenase 2

decreases expression

trovafloxacin results in decreased expression of BCO2 mRNA

NCBI chr 8:59,778,571...59,803,597
Ensembl chr 8:50,882,181...50,915,467

G

3-hydroxybutyrate dehydrogenase 1

increases expression

trovafloxacin results in increased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:69,302,534...69,337,671

G

3-hydroxybutyrate dehydrogenase 2

increases expression

trovafloxacin results in increased expression of BDH2 mRNA

NCBI chr 2:226,376,346...226,397,010
Ensembl chr 2:223,702,412...223,723,072

G

BEN domain containing 6

decreases expression

trovafloxacin results in decreased expression of BEND6 mRNA

NCBI chr 9:43,576,982...43,631,437
Ensembl chr 9:36,081,484...36,135,228

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Bet1 golgi vesicular membrane trafficking protein-like

increases expression

trovafloxacin results in increased expression of BET1L mRNA

NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:195,931,411...195,935,040

G

basic helix-loop-helix family, member e40

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 2

multiple interactions
decreases expression

trovafloxacin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]
trovafloxacin results in decreased expression of BIRC2 protein
[trovafloxacin co-treated with TNF protein] results in decreased expression of BIRC2 mRNA
trovafloxacin results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of BIRC3 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of BIRC3 mRNA
trovafloxacin results in decreased expression of BIRC3 mRNA

PMID:18930950 PMID:32035082

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

trovafloxacin results in decreased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BLM RecQ like helicase

decreases expression

trovafloxacin results in decreased expression of BLM mRNA

NCBI chr 1:143,819,072...143,905,300
Ensembl chr 1:134,409,857...134,484,312

G

biogenesis of lysosomal organelles complex-1, subunit 2

increases expression

trovafloxacin results in increased expression of BLOC1S2 mRNA

NCBI chr 1:252,973,818...252,980,873
Ensembl chr 1:243,024,614...243,031,653

G

basic leucine zipper nuclear factor 1

increases expression

trovafloxacin results in increased expression of BLZF1 mRNA

NCBI chr13:76,641,757...76,656,977
Ensembl chr13:76,641,515...76,656,999

G

Bcl2 modifying factor

decreases expression

trovafloxacin results in decreased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145

G

BCL2 family apoptosis regulator BOK

decreases expression

trovafloxacin results in decreased expression of BOK mRNA

NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476

G

bora, aurora kinase A activator

decreases expression

trovafloxacin results in decreased expression of BORA mRNA

NCBI chr15:82,205,467...82,243,499
Ensembl chr15:75,797,891...75,821,322

G

BLOC-1 related complex subunit 5

decreases expression

trovafloxacin results in decreased expression of BORCS5 mRNA

NCBI chr 4:169,190,025...169,272,335
Ensembl chr 4:167,473,177...167,540,993

G

biphenyl hydrolase like

decreases expression

trovafloxacin results in decreased expression of BPHL mRNA

NCBI chr17:31,006,283...31,042,631
Ensembl chr17:30,799,629...30,837,288

G

3'(2'), 5'-bisphosphate nucleotidase 1

decreases expression

trovafloxacin results in decreased expression of BPNT1 mRNA

NCBI chr13:99,397,127...99,425,056
Ensembl chr13:96,868,580...96,893,503

G

BRCA1, DNA repair associated

decreases expression

trovafloxacin results in decreased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

decreases expression

trovafloxacin results in decreased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

bromodomain containing 2

increases expression

trovafloxacin results in increased expression of BRD2 mRNA

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388

G

bromodomain testis associated

decreases expression

trovafloxacin results in decreased expression of BRDT mRNA

NCBI chr14:2,532,275...2,590,780
Ensembl chr14:2,387,796...2,445,842

G

BRCA1 interacting DNA helicase 1

decreases expression

trovafloxacin results in decreased expression of BRIP1 mRNA

NCBI chr10:71,402,035...71,528,083
Ensembl chr10:70,907,371...71,030,324

G

BSD domain containing 1

increases expression

trovafloxacin results in increased expression of BSDC1 mRNA

NCBI chr 5:141,798,918...141,827,091
Ensembl chr 5:141,798,981...141,827,092

G

bone marrow stromal cell antigen 2

decreases expression
increases expression

trovafloxacin results in decreased expression of BST2 mRNA
trovafloxacin results in increased expression of BST2 mRNA

PMID:24136188 PMID:35537566

NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,217,407...18,220,979

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

trovafloxacin results in decreased expression of BUB1 mRNA

NCBI chr 3:135,473,525...135,504,921
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

trovafloxacin results in decreased expression of BUB1B mRNA

NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 21 open reading frame 91

decreases expression

trovafloxacin results in decreased expression of D16ERTD472E mRNA

NCBI chr11:30,716,034...30,749,292
Ensembl chr11:17,229,138...17,262,483

G

C1D nuclear receptor corepressor

increases expression

trovafloxacin results in increased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:91,660,989...91,672,852

G

C1q and TNF related 12

increases expression

trovafloxacin results in increased expression of FAM132A mRNA

NCBI chr 5:171,833,854...171,838,229
Ensembl chr 5:166,551,628...166,556,003

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C1q and TNF related 6

decreases expression

trovafloxacin results in decreased expression of C1QTNF6 mRNA

NCBI chr 7:111,958,348...111,964,948
Ensembl chr 7:110,077,878...110,084,412

G

complement C1r subcomponent like

decreases expression

trovafloxacin results in decreased expression of C1RL mRNA

NCBI chr 4:159,080,495...159,097,066
Ensembl chr 4:157,394,200...157,410,134

G

C2 calcium-dependent domain containing 5

decreases expression

trovafloxacin results in decreased expression of C2CD5 mRNA

NCBI chr 4:177,700,515...177,790,576
Ensembl chr 4:175,969,545...176,055,558

G

similar to human chromosome 4 open reading frame 33

decreases expression

trovafloxacin results in decreased expression of D3ERTD751E mRNA

NCBI chr 2:124,764,263...124,830,001
Ensembl chr 2:124,769,940...124,832,449

G

similar to human chromosome 1 open reading frame 50

increases expression

trovafloxacin results in increased expression of C5H1ORF50 mRNA

NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762

G

complement C5 like 1

increases expression

trovafloxacin results in increased expression of C5L1 mRNA

NCBI chr 3:38,799,165...38,818,443
Ensembl chr 3:18,404,899...18,420,054

G

similar to human chromosome 11 open reading frame 54

decreases expression

trovafloxacin results in decreased expression of C8H11ORF54 mRNA

NCBI chr 8:20,405,240...20,427,811
Ensembl chr 8:12,123,823...12,146,473

G

calcium voltage-gated channel subunit alpha1 D

decreases expression

trovafloxacin results in decreased expression of CACNA1D mRNA

NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215

G

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

decreases expression

trovafloxacin results in decreased expression of CAD mRNA

NCBI chr 6:31,012,091...31,035,098
Ensembl chr 6:25,292,133...25,319,861

G

calcium homeostasis modulator family member 2

decreases expression

trovafloxacin results in decreased expression of CALHM2 mRNA

NCBI chr 1:255,963,661...255,969,387
Ensembl chr 1:246,022,324...246,028,218

G

calcium homeostasis modulator family member 6

decreases expression

trovafloxacin results in decreased expression of FAM26F mRNA

NCBI chr20:26,638,721...26,640,466
Ensembl chr20:26,095,592...26,097,278

G

calcium/calmodulin-dependent protein kinase kinase 2

decreases expression

trovafloxacin results in decreased expression of CAMKK2 mRNA

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279

G

calmodulin regulated spectrin-associated protein family, member 3

increases expression

trovafloxacin results in increased expression of CAMSAP3 mRNA

NCBI chr12:6,440,959...6,464,582
Ensembl chr12:1,643,251...1,666,685

G

cell cycle associated protein 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CAPRIN1 mRNA

NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502

G

carbonic anhydrase 12

decreases expression

trovafloxacin results in decreased expression of CAR12 mRNA

NCBI chr 8:76,169,723...76,225,465
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 7

decreases expression

trovafloxacin results in decreased expression of CAR7 mRNA

NCBI chr19:435,520...444,927
Ensembl chr19:429,075...438,467

G

caspase recruitment domain family, member 11

decreases expression

trovafloxacin results in decreased expression of CARD11 mRNA

NCBI chr12:18,735,088...18,872,045
Ensembl chr12:13,621,087...13,758,112

G

capping protein regulator and myosin 1 linker 2

increases expression

trovafloxacin results in increased expression of RLTPR mRNA

NCBI chr19:50,481,911...50,496,672
Ensembl chr19:33,574,257...33,586,965

G

cysteinyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:198,753,691...198,795,941

G

CAS1 domain containing 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASD1 mRNA

NCBI chr 4:33,613,805...33,705,821
Ensembl chr 4:32,658,748...32,739,202

G

caspase 3

multiple interactions
increases cleavage
increases activity

[TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein]
[TNF protein co-treated with trovafloxacin] results in increased cleavage of CASP3 protein

PMID:19638433 PMID:24097668 PMID:25748550 PMID:30876886 PMID:33609687

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases expression

trovafloxacin results in increased expression of CASP6 mRNA

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

decreases expression

trovafloxacin results in decreased expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

[trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

[trovafloxacin co-treated with TNF protein] results in increased activity of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

caveolin 1

increases expression

trovafloxacin results in increased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705

G

CBFA2/RUNX1 partner transcriptional co-repressor 3

decreases expression

trovafloxacin results in decreased expression of CBFA2T3 mRNA

NCBI chr19:67,584,319...67,658,533
Ensembl chr19:50,680,729...50,749,610

G

cystathionine beta synthase

decreases expression

trovafloxacin results in decreased expression of CBS mRNA

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,708,090...9,732,764

G

coiled-coil and C2 domain containing 1B

decreases expression

trovafloxacin results in decreased expression of CC2D1B mRNA

NCBI chr 5:128,581,962...128,596,045
Ensembl chr 5:123,353,292...123,367,318

G

coiled-coil and C2 domain containing 2A

decreases expression

trovafloxacin results in decreased expression of CC2D2A mRNA

NCBI chr14:71,563,835...71,648,352
Ensembl chr14:67,351,353...67,435,949

G

coiled-coil domain containing 137

increases expression

trovafloxacin results in increased expression of CCDC137 mRNA

NCBI chr10:106,229,099...106,235,502
Ensembl chr10:105,730,739...105,737,158

G

coiled-coil domain containing 15

decreases expression

trovafloxacin results in decreased expression of CCDC15 mRNA

NCBI chr 8:45,165,297...45,257,641
Ensembl chr 8:36,998,867...37,068,919

G

coiled-coil domain containing 163

decreases expression

trovafloxacin results in decreased expression of CCDC163 mRNA

NCBI chr 5:135,408,981...135,415,574
Ensembl chr 5:130,172,774...130,178,929

G

coiled-coil domain containing 18

decreases expression

trovafloxacin results in decreased expression of CCDC18 mRNA

NCBI chr14:1,646,725...1,752,581
Ensembl chr14:1,501,784...1,607,711

G

coiled-coil domain containing 181

decreases expression

trovafloxacin results in decreased expression of CCDC181 mRNA

NCBI chr13:76,624,567...76,638,224
Ensembl chr13:76,624,567...76,638,224

G

coiled-coil domain containing 34

decreases expression

trovafloxacin results in decreased expression of CCDC34 mRNA

NCBI chr 3:117,007,652...117,042,885
Ensembl chr 3:96,552,992...96,588,146

G

coiled-coil domain containing 6

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CCDC6 mRNA

NCBI chr20:18,431,243...18,527,227
Ensembl chr20:18,433,695...18,528,658

G

coiled-coil domain containing 62

decreases expression

trovafloxacin results in decreased expression of CCDC62 mRNA

NCBI chr12:38,284,089...38,320,828
Ensembl chr12:32,623,170...32,660,017

G

coiled-coil domain containing 74A

increases expression

trovafloxacin results in increased expression of CCDC74A mRNA

NCBI chr11:96,860,161...96,864,540
Ensembl chr11:83,355,874...83,360,378

G

coiled-coil domain containing 86

increases expression

trovafloxacin results in increased expression of CCDC86 mRNA

NCBI chr 1:217,015,059...217,021,439
Ensembl chr 1:207,590,168...207,596,544

G

coiled-coil domain containing 91

decreases expression

trovafloxacin results in decreased expression of CCDC91 mRNA

NCBI chr 4:182,132,931...182,304,948
Ensembl chr 4:180,402,376...180,574,364

G

C-C motif chemokine ligand 2

multiple interactions

trovafloxacin promotes the reaction [TNF protein results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 22

increases expression

trovafloxacin results in increased expression of CCL22 mRNA

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 3

increases expression

trovafloxacin results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

trovafloxacin results in increased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231

G

cyclin A2

decreases expression

trovafloxacin results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

trovafloxacin results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression

trovafloxacin results in decreased expression of CCNB2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression
increases expression

trovafloxacin results in decreased expression of CCND1 mRNA
trovafloxacin results in increased expression of CCND1 mRNA

PMID:24136188 PMID:35537566

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G2

decreases expression

trovafloxacin results in decreased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830

G

cyclin J

increases expression

trovafloxacin results in increased expression of CCNJ mRNA

NCBI chr 1:249,608,991...249,626,798

G

cyclin L1

increases expression

trovafloxacin results in increased expression of CCNL1 mRNA

NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:150,184,798...150,197,368

G

C-C motif chemokine receptor 10

increases expression

trovafloxacin results in increased expression of CCR10 mRNA

NCBI chr10:86,608,836...86,611,273
Ensembl chr10:86,108,551...86,110,988

G

centriole, cilia and spindle-associated protein

decreases expression

trovafloxacin results in decreased expression of CCSAP mRNA

NCBI chr19:68,722,417...68,740,908
Ensembl chr19:51,826,994...51,842,753

G

CD101 molecule

decreases expression

trovafloxacin results in decreased expression of CD101 mRNA

NCBI chr 2:191,109,782...191,148,184
Ensembl chr 2:188,422,351...188,459,502

G

CD109 molecule

decreases expression

trovafloxacin results in decreased expression of CD109 mRNA

NCBI chr 8:88,334,736...88,449,463
Ensembl chr 8:79,454,480...79,569,194

G

CD200 receptor 1-like

decreases expression

trovafloxacin results in decreased expression of CD200R4 mRNA

NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680

G

CD207 molecule

increases expression

trovafloxacin results in increased expression of CD207 mRNA

NCBI chr 4:117,712,879...117,719,191
Ensembl chr 4:116,155,212...116,161,518

G

CD24 molecule

decreases expression

trovafloxacin results in decreased expression of CD24A mRNA

NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662

G

CD244 molecule

decreases expression

trovafloxacin results in decreased expression of CD244 mRNA

NCBI chr13:86,583,727...86,606,902
Ensembl chr13:84,052,493...84,074,492

G

CD27 molecule

decreases expression

trovafloxacin results in decreased expression of CD27 mRNA

NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:158,030,703...158,035,592

G

CD300 molecule-like family member b

increases expression

trovafloxacin results in increased expression of CD300LB mRNA

NCBI chr10:100,463,815...100,473,804
Ensembl chr10:99,964,801...99,974,790

G

CD33 molecule

decreases expression

trovafloxacin results in decreased expression of CD33 mRNA

NCBI chr 1:103,071,985...103,086,687
Ensembl chr 1:93,930,971...93,950,149

G

CD36 molecule

decreases expression

trovafloxacin results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

Cd5 molecule

decreases expression

trovafloxacin results in decreased expression of CD5 mRNA

NCBI chr 1:216,790,245...216,811,209
Ensembl chr 1:207,365,337...207,386,313

G

Cd80 molecule

increases expression

trovafloxacin results in increased expression of CD80 mRNA

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

decreases expression

trovafloxacin results in decreased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

CD8 subunit beta

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CD8B mRNA

NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:103,312,578...103,328,553

G

cell division cycle 20

decreases expression

trovafloxacin results in decreased expression of CDC20 mRNA

PMID:24136188 PMID:35537566

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25B

decreases expression

trovafloxacin results in decreased expression of CDC25B mRNA

NCBI chr 3:138,860,148...138,870,287
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

decreases expression

trovafloxacin results in decreased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 26

increases expression

trovafloxacin results in increased expression of CDC26 mRNA

NCBI chr 5:80,861,658...80,875,326

G

cell division cycle 34, ubiquitin conjugating enzyme

increases expression

trovafloxacin results in increased expression of CDC34 mRNA

NCBI chr 7:10,668,209...10,674,206
Ensembl chr 7:10,017,588...10,023,186

G

CDC42 effector protein 4

increases expression

trovafloxacin results in increased expression of CDC42EP4 mRNA

NCBI chr10:99,271,750...99,298,551
Ensembl chr10:98,772,495...98,797,695

G

cell division cycle associated 2

decreases expression

trovafloxacin results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 3

decreases expression

trovafloxacin results in decreased expression of CDCA3 mRNA

NCBI chr 4:159,321,203...159,325,072
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 5

decreases expression

trovafloxacin results in decreased expression of CDCA5 mRNA

NCBI chr 1:212,807,863...212,821,313
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 8

decreases expression

trovafloxacin results in decreased expression of CDCA8 mRNA

NCBI chr 5:142,461,082...142,483,336
Ensembl chr 5:137,176,417...137,198,629

G

CDAN1 interacting nuclease 1

decreases expression

trovafloxacin results in decreased expression of CDIN1 mRNA

NCBI chr 3:122,895,754...123,101,099
Ensembl chr 3:102,441,704...102,646,682

G

cyclin-dependent kinase 1

decreases expression

trovafloxacin results in decreased expression of CDK1 mRNA

PMID:24136188 PMID:35537566

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

decreases expression

trovafloxacin results in decreased expression of CDK10 mRNA

NCBI chr19:68,168,040...68,184,923
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase 16

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CDK16 mRNA

NCBI chr X:4,046,330...4,057,825
Ensembl chr X:1,492,814...1,504,148

G

cyclin-dependent kinase 2 associated protein 2

increases expression

trovafloxacin results in increased expression of CDK2AP2 mRNA

NCBI chr 1:210,819,155...210,822,604
Ensembl chr 1:201,391,466...201,393,137

G

CDK5 regulatory subunit associated protein 2

decreases expression

trovafloxacin results in decreased expression of CDK5RAP2 mRNA

NCBI chr 5:88,807,402...88,976,005
Ensembl chr 5:83,792,284...83,960,782

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CDKN1A mRNA
trovafloxacin results in increased expression of CDKN1A mRNA

PMID:18930950 PMID:25748550 PMID:35537566

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2C

decreases expression

trovafloxacin results in decreased expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:124,411,124...124,416,278

G

cyclin dependent kinase inhibitor 2D

decreases expression

trovafloxacin results in decreased expression of CDKN2D mRNA

NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674

G

cyclin-dependent kinase inhibitor 3

decreases expression

trovafloxacin results in decreased expression of CDKN3 mRNA

PMID:24136188 PMID:35537566

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:20,022,664...20,033,945

G

cysteine dioxygenase type 1

increases expression

trovafloxacin results in increased expression of CDO1 mRNA

NCBI chr18:41,619,076...41,633,719
Ensembl chr18:39,432,474...39,447,296

G

cell adhesion associated, oncogene regulated

decreases expression

trovafloxacin results in decreased expression of CDON mRNA

NCBI chr 8:42,032,921...42,119,451
Ensembl chr 8:33,806,183...33,859,033

G

corneodesmosin

decreases expression

trovafloxacin results in decreased expression of CDSN mRNA

NCBI chr20:3,184,142...3,188,962
Ensembl chr20:3,179,438...3,184,250

G

CCAAT/enhancer binding protein alpha

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein gamma

decreases expression

trovafloxacin results in decreased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:87,684,019...87,694,569

G

CUGBP, Elav-like family member 6

decreases expression

trovafloxacin results in decreased expression of CELF6 mRNA

NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:59,975,088...60,005,041

G

centrosomal AT-AC splicing factor

increases expression

trovafloxacin results in increased expression of CENATAC mRNA

NCBI chr 8:53,632,777...53,639,661
Ensembl chr 8:44,735,972...44,742,837

G

centromere protein A

decreases expression

trovafloxacin results in decreased expression of CENPA mRNA

NCBI chr 6:31,420,062...31,431,703
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein E

decreases expression

trovafloxacin results in decreased expression of CENPE mRNA

NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein F

decreases expression

trovafloxacin results in decreased expression of CENPF mRNA

NCBI chr13:103,715,344...103,760,931
Ensembl chr13:101,184,127...101,229,669

G

centromere protein I

decreases expression

trovafloxacin results in decreased expression of CENPI mRNA

NCBI chr X:101,809,192...101,860,935
Ensembl chr X:97,515,972...97,567,657

G

centromere protein K

decreases expression

trovafloxacin results in decreased expression of CENPK mRNA

NCBI chr 2:37,094,163...37,155,158
Ensembl chr 2:35,360,132...35,385,706

G

centromere protein L

decreases expression

trovafloxacin results in decreased expression of CENPL mRNA

NCBI chr13:75,870,479...75,885,466
Ensembl chr13:73,337,257...73,352,114

G

centromere protein M

decreases expression

trovafloxacin results in decreased expression of CENPM mRNA

NCBI chr 7:115,628,117...115,639,401
Ensembl chr 7:113,747,516...113,764,258

G

centromere protein N

decreases expression

trovafloxacin results in decreased expression of CENPN mRNA

NCBI chr19:61,880,101...61,902,850
Ensembl chr19:44,968,308...44,994,012

G

centromere protein P

decreases expression

trovafloxacin results in decreased expression of CENPP mRNA

NCBI chr17:15,220,521...15,395,741
Ensembl chr17:15,014,058...15,189,304

G

centromere protein Q

decreases expression

trovafloxacin results in decreased expression of CENPQ mRNA

NCBI chr 9:27,454,339...27,469,371
Ensembl chr 9:19,957,048...19,972,789

G

centromere protein U

decreases expression

trovafloxacin results in decreased expression of CENPU mRNA

NCBI chr16:52,448,446...52,471,662
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 128

decreases expression

trovafloxacin results in decreased expression of CEP128 mRNA

NCBI chr 6:115,681,753...116,059,758
Ensembl chr 6:109,951,061...110,328,713

G

centrosomal protein 131

decreases expression

trovafloxacin results in decreased expression of CEP131 mRNA

NCBI chr10:105,844,433...105,868,811
Ensembl chr10:105,346,015...105,370,380

G

centrosomal protein 162

decreases expression

trovafloxacin results in decreased expression of CEP162 mRNA

NCBI chr 8:97,029,677...97,088,243
Ensembl chr 8:88,149,726...88,206,830

G

centrosomal protein 192

decreases expression

trovafloxacin results in decreased expression of CEP192 mRNA

NCBI chr18:63,643,816...63,728,264
Ensembl chr18:61,332,158...61,458,379

G

centrosomal protein 290

decreases expression

trovafloxacin results in decreased expression of CEP290 mRNA

NCBI chr 7:37,196,765...37,285,955
Ensembl chr 7:35,310,199...35,399,392

G

centrosomal protein 55

decreases expression

trovafloxacin results in decreased expression of CEP55 mRNA

NCBI chr 1:245,245,272...245,260,835
Ensembl chr 1:235,832,878...235,848,394

G

centrosomal protein 57-like 1

decreases expression

trovafloxacin results in decreased expression of CEP57L1 mRNA

NCBI chr20:46,820,350...46,876,911
Ensembl chr20:45,238,044...45,294,540

G

centrosomal protein 72

decreases expression

trovafloxacin results in decreased expression of CEP72 mRNA

NCBI chr 1:31,053,884...31,083,863
Ensembl chr 1:29,225,361...29,255,271

G

centrosomal protein 78

decreases expression

trovafloxacin results in decreased expression of CEP78 mRNA

NCBI chr 1:222,674,193...222,702,124
Ensembl chr 1:213,246,187...213,275,181

G

centrosomal protein 83

decreases expression

trovafloxacin results in decreased expression of CEP83 mRNA

NCBI chr 7:31,167,198...31,276,513
Ensembl chr 7:29,280,419...29,389,574

G

CERK like autophagy regulator

decreases expression

trovafloxacin results in decreased expression of CERKL mRNA

NCBI chr 3:84,641,121...84,747,999
Ensembl chr 3:64,237,522...64,340,675

G

cilia and flagella associated protein 184

increases expression

trovafloxacin results in increased expression of CCDC96 mRNA

NCBI chr14:78,501,256...78,503,715
Ensembl chr14:74,276,960...74,278,888

G

cofilin 2

increases expression

trovafloxacin results in increased expression of CFL2 mRNA

NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:72,355,664...72,359,674

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

decreases expression

trovafloxacin results in decreased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:106,342,302...106,345,526

G

chondroadherin-like

increases expression

trovafloxacin results in increased expression of CHADL mRNA

NCBI chr 7:115,085,447...115,097,565
Ensembl chr 7:113,210,748...113,217,272

G

chromodomain helicase DNA binding protein 5

decreases expression

trovafloxacin results in decreased expression of CHD5 mRNA

NCBI chr 5:168,130,851...168,181,705
Ensembl chr 5:162,848,394...162,896,291

G

checkpoint with forkhead and ring finger domains

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CHFR mRNA

NCBI chr12:52,164,214...52,197,860
Ensembl chr12:46,504,497...46,538,014

G

choline kinase alpha

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CHKA mRNA

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:201,076,860...201,125,516

G

chondroitin polymerizing factor

increases expression

trovafloxacin results in increased expression of CHPF mRNA

NCBI chr 9:84,411,824...84,416,523
Ensembl chr 9:76,963,184...76,967,878

G

carbohydrate sulfotransferase 1

decreases expression

trovafloxacin results in decreased expression of CHST1 mRNA

NCBI chr 3:99,003,987...99,030,214
Ensembl chr 3:78,548,525...78,574,883

G

carbohydrate sulfotransferase 7

decreases expression

trovafloxacin results in decreased expression of CHST7 mRNA

NCBI chr X:4,949,810...4,986,372
Ensembl chr X:2,393,874...2,432,840

G

chromosome transmission fidelity factor 18

decreases expression

trovafloxacin results in decreased expression of CHTF18 mRNA

NCBI chr10:15,247,525...15,255,573
Ensembl chr10:14,742,621...14,751,050

G

calcium and integrin binding family member 2

decreases expression

trovafloxacin results in decreased expression of CIB2 mRNA

NCBI chr 8:63,826,410...63,843,301

G

cellular inhibitor of PP2A

decreases expression

trovafloxacin results in decreased expression of CIP2A mRNA

NCBI chr11:65,255,123...65,285,914
Ensembl chr11:51,795,024...51,822,938

G

citron rho-interacting serine/threonine kinase

decreases expression

trovafloxacin results in decreased expression of CIT mRNA

NCBI chr12:46,263,881...46,425,642
Ensembl chr12:40,605,563...40,763,860

G

cytoskeleton associated protein 2

decreases expression

trovafloxacin results in decreased expression of CKAP2 mRNA

NCBI chr16:76,542,114...76,567,297
Ensembl chr16:69,839,630...69,864,913

G

cytoskeleton associated protein 2-like

decreases expression

trovafloxacin results in decreased expression of CKAP2L mRNA

NCBI chr 3:136,950,390...136,977,503
Ensembl chr 3:116,498,022...116,524,366

G

cytoskeleton associated protein 5

decreases expression

trovafloxacin results in decreased expression of CKAP5 mRNA

NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:77,491,276...77,593,264

G

CDC28 protein kinase regulatory subunit 2

decreases expression

trovafloxacin results in decreased expression of CKS2 mRNA

NCBI chr17:13,722,360...13,727,519

G

chloride voltage-gated channel 5

decreases expression

trovafloxacin results in decreased expression of CLCN5 mRNA

NCBI chr X:17,857,260...18,011,844
Ensembl chr X:15,185,451...15,334,264

G

claudin 11

decreases expression

trovafloxacin results in decreased expression of CLDN11 mRNA

NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:112,207,745...112,221,050

G

claudin 14

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CLDN14 mRNA

NCBI chr11:46,701,940...46,799,049
Ensembl chr11:33,232,220...33,329,171

G

C-type lectin domain family 2, member L

decreases expression

trovafloxacin results in decreased expression of CLEC2L mRNA

NCBI chr 4:68,359,021...68,381,431
Ensembl chr 4:67,397,873...67,414,537

G

C-type lectin domain family 4, member A1

decreases expression

trovafloxacin results in decreased expression of CLEC4A1 mRNA

NCBI chr 4:157,845,811...157,857,926
Ensembl chr 4:156,173,894...156,186,008

G

C-type lectin domain containing 7A

decreases expression

trovafloxacin results in decreased expression of CLEC7A mRNA

NCBI chr 4:164,588,737...164,599,953
Ensembl chr 4:162,902,732...162,913,897

G

clathrin interactor 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CLINT1 mRNA

NCBI chr10:30,799,936...30,854,513
Ensembl chr10:30,298,704...30,353,063

G

CAP-GLY domain containing linker protein 2

increases expression

trovafloxacin results in increased expression of CLIP2 mRNA

NCBI chr12:27,798,289...27,863,486
Ensembl chr12:22,163,218...22,227,023

G

CDC-like kinase 1

increases expression

trovafloxacin results in increased expression of CLK1 mRNA

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:59,947,764...59,957,000

G

CLN6, transmembrane ER protein

decreases expression

trovafloxacin results in decreased expression of CLN6 mRNA

NCBI chr 8:72,198,773...72,213,777
Ensembl chr 8:63,303,029...63,318,360

G

claspin

decreases expression

trovafloxacin results in decreased expression of CLSPN mRNA

NCBI chr 5:144,134,619...144,169,531
Ensembl chr 5:138,850,128...138,885,034

G

cytidine monophospho-N-acetylneuraminic acid hydroxylase

decreases expression

trovafloxacin results in decreased expression of CMAH mRNA

NCBI chr17:40,985,129...41,070,317
Ensembl chr17:40,583,667...40,642,275

G

carboxymethylenebutenolidase homolog

decreases expression

trovafloxacin results in decreased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:82,571,888...82,591,009

G

cytidine/uridine monophosphate kinase 2

increases expression

trovafloxacin results in increased expression of CMPK2 mRNA

NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:43,073,796...43,085,183

G

centlein

decreases expression

trovafloxacin results in decreased expression of CNTLN mRNA

NCBI chr 5:104,340,801...104,622,491
Ensembl chr 5:99,296,000...99,576,396

G

centriolin

decreases expression

trovafloxacin results in decreased expression of CNTRL mRNA

NCBI chr 3:38,825,575...38,897,835
Ensembl chr 3:18,428,103...18,500,380

G

centrobin, centriole duplication and spindle assembly protein

decreases expression

trovafloxacin results in decreased expression of CNTROB mRNA

NCBI chr10:54,521,338...54,546,569
Ensembl chr10:54,022,852...54,044,849

G

Coenzyme A synthase

decreases expression

trovafloxacin results in decreased expression of COASY mRNA

NCBI chr10:86,514,850...86,519,130
Ensembl chr10:86,014,597...86,018,841

G

collagen type XIV alpha 1 chain

decreases expression

trovafloxacin results in decreased expression of COL14A1 mRNA

NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:86,722,094...86,937,214

G

collagen type XV alpha 1 chain

decreases expression

trovafloxacin results in decreased expression of COL15A1 mRNA

NCBI chr 5:66,297,546...66,403,172
Ensembl chr 5:61,501,963...61,607,591

G

catechol-O-methyltransferase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

COPI coat complex subunit gamma 1

decreases expression

trovafloxacin results in decreased expression of COPG1 mRNA

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:120,366,542...120,415,616

G

COP9 signalosome subunit 9

increases expression

trovafloxacin results in increased expression of MYEOV2 mRNA

NCBI chr 9:100,657,276...100,662,206
Ensembl chr 9:93,209,843...93,213,317

G

coenzyme Q10A

decreases expression

trovafloxacin results in decreased expression of COQ10A mRNA

NCBI chr 7:1,376,591...1,387,694
Ensembl chr 7:792,089...800,161

G

coenzyme Q2, polyprenyltransferase

decreases expression

trovafloxacin results in decreased expression of COQ2 mRNA

NCBI chr14:9,245,777...9,265,784
Ensembl chr14:8,941,461...8,960,891

G

coronin 1B

decreases expression

trovafloxacin results in decreased expression of CORO1B mRNA

NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:201,443,014...201,448,416

G

coronin 6

decreases expression

trovafloxacin results in decreased expression of CORO6 mRNA

NCBI chr10:62,808,172...62,817,788
Ensembl chr10:62,311,660...62,319,659

G

coronin 7

decreases expression

trovafloxacin results in decreased expression of CORO7 mRNA

NCBI chr10:11,386,683...11,447,422
Ensembl chr10:10,885,196...10,941,001

G

cytochrome c oxidase subunit 4i2

increases expression

trovafloxacin results in increased expression of COX4I2 mRNA

NCBI chr 3:161,686,193...161,699,605
Ensembl chr 3:141,228,443...141,239,331

G

cytochrome c oxidase subunit 6A2

decreases expression

trovafloxacin results in decreased expression of COX6A2 mRNA

NCBI chr 1:192,218,970...192,221,188
Ensembl chr 1:182,788,528...182,789,274

G

carboxypeptidase E

increases expression

trovafloxacin results in increased expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:25,030,276...25,142,233

G

cytoplasmic polyadenylation element binding protein 4

increases expression

trovafloxacin results in increased expression of CPEB4 mRNA

NCBI chr10:16,222,271...16,284,248
Ensembl chr10:15,717,794...15,780,603

G

cadherin-like and PC-esterase domain containing 1

decreases expression

trovafloxacin results in decreased expression of CPED1 mRNA

NCBI chr 4:51,482,497...51,755,440
Ensembl chr 4:50,516,819...50,788,674

G

coproporphyrinogen oxidase

decreases expression

trovafloxacin results in decreased expression of CPOX mRNA

NCBI chr11:55,405,778...55,415,761
Ensembl chr11:41,936,591...41,946,746

G

cleavage and polyadenylation specific factor 1

decreases expression

trovafloxacin results in decreased expression of CPSF1 mRNA

NCBI chr 7:110,200,078...110,210,644
Ensembl chr 7:108,319,434...108,329,934

G

carnitine palmitoyltransferase 1A

increases expression

trovafloxacin results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

trovafloxacin results in decreased expression of CRADD mRNA

NCBI chr 7:31,827,131...31,839,796
Ensembl chr 7:29,798,586...29,952,907

G

CREB/ATF bZIP transcription factor

increases expression

trovafloxacin results in increased expression of CREBZF mRNA

NCBI chr 1:153,829,544...153,836,073
Ensembl chr 1:144,417,446...144,428,553

G

CRK proto-oncogene, adaptor protein

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CRK mRNA

NCBI chr10:61,028,736...61,054,971
Ensembl chr10:60,530,464...60,553,406

G

crystallin zeta like 1

decreases expression

trovafloxacin results in decreased expression of CRYZL1 mRNA

NCBI chr11:44,419,099...44,464,366
Ensembl chr11:30,933,144...30,977,867

G

citrate synthase

decreases expression

trovafloxacin results in decreased expression of CS mRNA

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421

G

cysteine sulfinic acid decarboxylase

decreases expression

trovafloxacin results in decreased expression of CSAD mRNA

NCBI chr 7:135,187,175...135,216,495
Ensembl chr 7:133,308,574...133,337,615

G

cysteine and serine rich nuclear protein 1

increases expression

trovafloxacin results in increased expression of CSRNP1 mRNA

NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:119,704,713...119,718,183

G

cystatin F

decreases expression

trovafloxacin results in decreased expression of CST7 mRNA

NCBI chr 3:159,857,221...159,865,987
Ensembl chr 3:139,396,850...139,405,557

G

cleavage stimulation factor subunit 2, tau variant

increases expression

trovafloxacin results in increased expression of CSTF2T mRNA

NCBI chr 1:238,366,042...238,369,608
Ensembl chr 1:228,952,504...228,955,873

G

CTD small phosphatase 1

decreases expression

trovafloxacin results in decreased expression of CTDSP1 mRNA

NCBI chr 9:83,422,755...83,428,411
Ensembl chr 9:75,973,962...75,979,297

G

cystathionine gamma-lyase

decreases expression

trovafloxacin results in decreased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin C

decreases expression

trovafloxacin results in decreased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin E

decreases expression

trovafloxacin results in decreased expression of CTSE mRNA

NCBI chr13:45,644,168...45,666,722
Ensembl chr13:43,092,128...43,114,502

G

cathepsin F

decreases expression

trovafloxacin results in decreased expression of CTSF mRNA

NCBI chr 1:211,582,169...211,587,917
Ensembl chr 1:202,152,728...202,158,525

G

CTTNBP2 N-terminal like

increases expression

trovafloxacin results in increased expression of CTTNBP2NL mRNA

NCBI chr 2:195,196,318...195,244,792
Ensembl chr 2:192,507,963...192,541,101

G

cutC copper transporter

decreases expression

trovafloxacin results in decreased expression of CUTC mRNA

NCBI chr 1:252,571,489...252,586,269
Ensembl chr 1:242,622,276...242,637,047

G

cut-like homeobox 2

increases expression

trovafloxacin results in increased expression of CUX2 mRNA

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:34,520,959...34,705,806

G

C-X-C motif chemokine ligand 2

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL2 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL2 protein]
trovafloxacin results in increased expression of CXCL2 mRNA

PMID:18930950 PMID:19638433 PMID:35537566

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CXCL3 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL1 protein]

PMID:18930950 PMID:19638433

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b5 type A

increases expression

trovafloxacin results in increased expression of CYB5A mRNA

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome b5 domain containing 1

increases expression

trovafloxacin results in increased expression of CYB5D1 mRNA

NCBI chr10:54,612,230...54,616,375
Ensembl chr10:54,113,438...54,117,911

G

cytochrome b5 reductase-like

decreases expression

trovafloxacin results in decreased expression of CYB5RL mRNA

NCBI chr 5:127,075,034...127,097,551
Ensembl chr 5:121,847,952...121,868,745

G

cytoplasmic FMR1 interacting protein 2

decreases expression

trovafloxacin results in decreased expression of CYFIP2 mRNA

NCBI chr10:31,122,653...31,242,440
Ensembl chr10:30,621,318...30,741,113

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

trovafloxacin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 27, subfamily a, polypeptide 1

decreases expression

trovafloxacin results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 12

decreases expression

trovafloxacin results in decreased expression of CYP2B12 mRNA

NCBI chr 1:91,135,294...91,147,094
Ensembl chr 1:82,007,609...82,080,480

G

cytochrome P450, family 2, subfamily u, polypeptide 1

decreases expression

trovafloxacin results in decreased expression of CYP2U1 mRNA

NCBI chr 2:222,523,516...222,541,055
Ensembl chr 2:219,849,407...219,866,882

G

cytochrome P450, family 4, subfamily f, polypeptide 39

decreases expression

trovafloxacin results in decreased expression of CYP4F39 mRNA

NCBI chr 7:12,082,821...12,156,076
Ensembl chr 7:11,433,371...11,536,181

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

increases expression

trovafloxacin results in increased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

cell cycle regulator of NHEJ

decreases expression

trovafloxacin results in decreased expression of CYREN mRNA

NCBI chr 4:64,514,477...64,519,896
Ensembl chr 4:63,547,335...63,551,602

G

cytohesin 4

increases expression

trovafloxacin results in increased expression of CYTH4 mRNA

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:110,152,272...110,176,741

G

differentiation antagonizing non-protein coding RNA

increases expression

trovafloxacin results in increased expression of DANCR mRNA

NCBI chr14:34,481,052...34,482,032

G

death associated protein kinase 1

decreases expression

trovafloxacin results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991

G

aspartyl-tRNA synthetase 2 (mitochondrial)

decreases expression

trovafloxacin results in decreased expression of DARS2 mRNA

NCBI chr13:75,842,078...75,870,319
Ensembl chr13:73,308,726...73,336,934

G

death-domain associated protein

increases expression

trovafloxacin results in increased expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,970,092...4,975,843

G

DBF4-CDC7 kinase regulatory subunit

decreases expression

trovafloxacin results in decreased expression of DBF4 mRNA

NCBI chr 4:26,631,491...26,656,080
Ensembl chr 4:25,676,634...25,701,066

G

decapping mRNA 1B

decreases expression

trovafloxacin results in decreased expression of DCP1B mRNA

NCBI chr 4:154,030,181...154,068,038
Ensembl chr 4:152,358,241...152,397,145

G

DNA-damage inducible transcript 3

decreases expression

trovafloxacin results in decreased expression of DDIT3 mRNA

PMID:24136188 PMID:35537566

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 1

decreases expression

trovafloxacin results in decreased expression of DDX1 mRNA

NCBI chr 6:41,725,365...41,756,236
Ensembl chr 6:35,996,469...36,027,365

G

DEAD-box helicase 17

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DDX17 mRNA

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 23

increases expression

trovafloxacin results in increased expression of DDX23 mRNA

NCBI chr 7:131,676,636...131,693,917
Ensembl chr 7:129,797,614...129,814,949

G

DEAD-box helicase 59

decreases expression

trovafloxacin results in decreased expression of DDX59 mRNA

NCBI chr13:50,427,940...50,452,893
Ensembl chr13:47,876,261...47,901,214

G

DEAD-box helicase 6

increases expression

trovafloxacin results in increased expression of DDX6 mRNA

NCBI chr 8:53,827,661...53,864,538
Ensembl chr 8:44,931,974...44,964,405
Ensembl chr 8:44,931,974...44,964,405

G

DEXD/H-box helicase 60

increases expression

trovafloxacin results in increased expression of DDX60 mRNA

NCBI chr16:33,087,940...33,208,843
Ensembl chr16:28,076,999...28,179,526

G

DEK proto-oncogene

decreases expression

trovafloxacin results in decreased expression of DEK mRNA

NCBI chr17:17,786,989...17,809,096
Ensembl chr17:17,580,843...17,602,808

G

DENN domain containing 2D

decreases expression

trovafloxacin results in decreased expression of DENND2D mRNA

NCBI chr 2:196,661,465...196,680,505
Ensembl chr 2:193,973,231...193,992,270

G

DENN domain containing 4A

decreases expression

trovafloxacin results in decreased expression of DENND4A mRNA

NCBI chr 8:74,218,131...74,331,543
Ensembl chr 8:65,322,941...65,436,330

G

DENN domain containing 5B

increases expression

trovafloxacin results in increased expression of DENND5B mRNA

NCBI chr 4:183,688,039...183,821,012
Ensembl chr 4:181,961,386...182,089,362

G

DEP domain containing 1

decreases expression

trovafloxacin results in decreased expression of DEPDC1A mRNA

NCBI chr 2:251,343,250...251,376,709
Ensembl chr 2:248,684,523...248,717,951

G

DEP domain containing 1B

decreases expression

trovafloxacin results in decreased expression of DEPDC1B mRNA

NCBI chr 2:41,605,686...41,697,207
Ensembl chr 2:39,891,481...39,963,779

G

DEP domain containing 7

decreases expression

trovafloxacin results in decreased expression of DEPDC7 mRNA

NCBI chr 3:111,554,701...111,575,979
Ensembl chr 3:91,099,835...91,121,124

G

DEP domain containing MTOR-interacting protein

decreases expression

trovafloxacin results in decreased expression of DEPTOR mRNA

NCBI chr 7:88,404,745...88,574,065
Ensembl chr 7:86,514,988...86,667,773

G

derlin 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DERL2 mRNA

NCBI chr10:56,226,340...56,238,038
Ensembl chr10:55,727,643...55,739,518

G

DET1 partner of COP1 E3 ubiquitin ligase

decreases expression

trovafloxacin results in decreased expression of DET1 mRNA

NCBI chr 1:142,159,120...142,175,366
Ensembl chr 1:132,749,756...132,765,923

G

DNA fragmentation factor subunit beta

increases expression

trovafloxacin results in increased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628

G

diacylglycerol O-acyltransferase 2

decreases expression

trovafloxacin results in decreased expression of DGAT2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:153,454,080...153,484,428

G

diacylglycerol kinase epsilon

increases expression

trovafloxacin results in increased expression of DGKE mRNA

NCBI chr10:74,348,931...74,374,509
Ensembl chr10:73,855,583...73,877,100

G

diacylglycerol kinase, gamma

decreases expression

trovafloxacin results in decreased expression of DGKG mRNA

NCBI chr11:91,888,957...92,083,715
Ensembl chr11:78,384,458...78,577,212

G

deoxyguanosine kinase

decreases expression

trovafloxacin results in decreased expression of DGUOK mRNA

NCBI chr 4:117,544,784...117,572,414
Ensembl chr 4:115,979,094...116,014,733

G

dehydrogenase/reductase 3

decreases expression

trovafloxacin results in decreased expression of DHRS3 mRNA

NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:156,747,962...156,782,417

G

dehydrogenase/reductase 4

decreases expression

trovafloxacin results in decreased expression of DHRS4 mRNA

NCBI chr15:32,924,482...32,948,103
Ensembl chr15:28,966,553...28,978,127

G

DEXH-box helicase 58

increases expression

trovafloxacin results in increased expression of DHX58 mRNA

NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525

G

diaphanous-related formin 3

decreases expression

trovafloxacin results in decreased expression of DIAPH3 mRNA

NCBI chr15:68,951,992...69,421,623
Ensembl chr15:62,543,375...63,012,975

G

dispatched RND transporter family member 3

decreases expression

trovafloxacin results in decreased expression of DISP3 mRNA

NCBI chr 5:163,955,160...164,003,980
Ensembl chr 5:158,672,015...158,720,806

G

DIX domain containing 1

decreases expression

trovafloxacin results in decreased expression of DIXDC1 mRNA

NCBI chr 8:59,904,218...59,977,595
Ensembl chr 8:51,007,838...51,081,090

G

DLG associated protein 5

decreases expression

trovafloxacin results in decreased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:20,633,966...20,664,518

G

dihydrolipoamide S-succinyltransferase

decreases expression

trovafloxacin results in decreased expression of DLST mRNA

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296

G

distal membrane arm assembly component 1

increases expression

trovafloxacin results in increased expression of DMAC1 mRNA

NCBI chr 5:94,288,900...94,290,053
Ensembl chr 5:89,242,661...89,243,757

G

DM1 protein kinase

increases expression

trovafloxacin results in increased expression of DMPK mRNA

NCBI chr 1:87,858,294...87,868,624
Ensembl chr 1:78,730,275...78,740,593

G

dynein, axonemal, heavy chain 17

increases expression

trovafloxacin results in increased expression of DNAH17 mRNA

NCBI chr10:103,748,033...103,862,009
Ensembl chr10:103,249,363...103,364,901

G

DnaJ heat shock protein family (Hsp40) member B2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of DNAJB2 mRNA

NCBI chr 9:84,179,702...84,187,942
Ensembl chr 9:76,731,065...76,739,277

G

deoxyribonuclease 2, lysosomal

decreases expression

trovafloxacin results in decreased expression of DNASE2A mRNA

NCBI chr19:40,149,505...40,152,225
Ensembl chr19:23,244,664...23,247,376

G

DND microRNA-mediated repression inhibitor 1

increases expression

trovafloxacin results in increased expression of DND1 mRNA

NCBI chr18:28,652,712...28,655,336
Ensembl chr18:28,378,692...28,381,316

G

DNA methyltransferase 1

decreases expression

trovafloxacin results in decreased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 like

decreases expression

trovafloxacin results in decreased expression of DNMT3L mRNA

NCBI chr20:10,614,591...10,628,989
Ensembl chr20:10,614,934...10,629,516

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

trovafloxacin results in decreased expression of DNPH1 mRNA

NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:14,481,066...14,484,022

G

dedicator of cytokinesis 11

decreases expression

trovafloxacin results in decreased expression of DOCK11 mRNA

NCBI chr X:119,997,523...120,180,643
Ensembl chr X:115,131,909...115,314,854

G

dedicator of cytokinesis 2

decreases expression

trovafloxacin results in decreased expression of DOCK2 mRNA

NCBI chr10:19,331,412...19,748,987
Ensembl chr10:18,827,239...19,244,808

G

dedicator of cytokinesis 9

decreases expression

trovafloxacin results in decreased expression of DOCK9 mRNA

NCBI chr15:105,018,341...105,289,799
Ensembl chr15:98,618,084...98,883,153

G

DNA replication fork stabilization factor DONSON

decreases expression

trovafloxacin results in decreased expression of DONSON mRNA

NCBI chr11:44,405,794...44,419,099
Ensembl chr11:30,923,239...30,932,889

G

double PHD fingers 1

increases expression

trovafloxacin results in increased expression of DPF1 mRNA

NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:84,602,336...84,615,950

G

dynein regulatory complex subunit 3

decreases expression

trovafloxacin results in decreased expression of DRC3 mRNA

NCBI chr10:45,620,045...45,698,902
Ensembl chr10:45,157,354...45,199,369

G

DNA replication and sister chromatid cohesion 1

decreases expression

trovafloxacin results in decreased expression of DSCC1 mRNA

NCBI chr 7:88,372,349...88,390,815
Ensembl chr 7:86,482,588...86,498,212

G

DSN1 component of MIS12 kinetochore complex

decreases expression

trovafloxacin results in decreased expression of DSN1 mRNA

NCBI chr 3:166,072,775...166,089,029
Ensembl chr 3:145,652,737...145,665,856

G

dystrobrevin, beta

decreases expression

trovafloxacin results in decreased expression of DTNB mRNA

NCBI chr 6:32,286,022...32,483,007
Ensembl chr 6:26,566,925...26,766,335

G

dystrobrevin binding protein 1

decreases expression

trovafloxacin results in decreased expression of DTNBP1 mRNA

NCBI chr17:19,891,313...19,982,770
Ensembl chr17:19,685,215...19,776,661

G

deltex E3 ubiquitin ligase 1

decreases expression

trovafloxacin results in decreased expression of DTX1 mRNA

NCBI chr12:41,510,252...41,541,433
Ensembl chr12:35,849,617...35,880,838

G

deoxythymidylate kinase

decreases expression

trovafloxacin results in decreased expression of DTYMK mRNA

NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:94,315,552...94,324,870

G

dihydrouridine synthase 1-like

decreases expression

trovafloxacin results in decreased expression of DUS1L mRNA

NCBI chr10:106,553,841...106,560,977
Ensembl chr10:106,055,519...106,062,781

G

dihydrouridine synthase 4-like

decreases expression

trovafloxacin results in decreased expression of DUS4L mRNA

NCBI chr 6:53,955,609...53,970,050
Ensembl chr 6:48,228,111...48,242,449

G

dual specificity phosphatase 1

increases expression

trovafloxacin results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

dual specificity phosphatase 16

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP16 mRNA

NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:167,548,155...167,629,980

G

dual specificity phosphatase 2

increases expression

trovafloxacin results in increased expression of DUSP2 mRNA

NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 5

increases expression

trovafloxacin results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 8

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP8 mRNA

NCBI chr 1:206,596,912...206,613,728
Ensembl chr 1:197,169,422...197,182,921

G

deoxyuridine triphosphatase

decreases expression

trovafloxacin results in decreased expression of DUT mRNA

PMID:24136188 PMID:35537566

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:112,498,982...112,510,771

G

dymeclin

decreases expression

trovafloxacin results in decreased expression of DYM mRNA

NCBI chr18:70,879,835...71,176,006
Ensembl chr18:68,605,185...68,900,903

G

dynein 2 intermediate chain 2

decreases expression

trovafloxacin results in decreased expression of DYNC2I2 mRNA

NCBI chr 3:33,703,882...33,719,960
Ensembl chr 3:13,306,039...13,322,121

G

dual specificity tyrosine phosphorylation regulated kinase 1B

increases expression

trovafloxacin results in increased expression of DYRK1B mRNA

NCBI chr 1:92,606,743...92,624,089
Ensembl chr 1:83,479,147...83,487,169

G

dual specificity tyrosine phosphorylation regulated kinase 3

increases expression

trovafloxacin results in increased expression of DYRK3 mRNA

NCBI chr13:45,146,383...45,157,082
Ensembl chr13:42,594,121...42,604,778

G

DAZ interacting zinc finger protein 3

decreases expression

trovafloxacin results in decreased expression of DZIP3 mRNA

NCBI chr11:65,286,190...65,356,314
Ensembl chr11:51,823,231...51,893,353

G

E2F transcription factor 1

decreases expression

trovafloxacin results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 7

decreases expression

trovafloxacin results in decreased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

decreases expression

trovafloxacin results in decreased expression of E2F8 mRNA

NCBI chr 1:107,701,985...107,720,538
Ensembl chr 1:98,565,717...98,584,098

G

ELL associated factor 1

increases expression

trovafloxacin results in increased expression of EAF1 mRNA

NCBI chr16:6,704,727...6,719,476
Ensembl chr16:6,698,322...6,713,071

G

glutamyl-tRNA synthetase 2, mitochondrial

decreases expression

trovafloxacin results in decreased expression of EARS2 mRNA

NCBI chr 1:186,025,740...186,057,165
Ensembl chr 1:176,597,986...176,625,836

G

enoyl CoA hydratase domain containing 2

decreases expression

trovafloxacin results in decreased expression of ECHDC2 mRNA

NCBI chr 5:128,144,241...128,163,611
Ensembl chr 5:122,916,134...122,934,859

G

enoyl CoA hydratase domain containing 3

decreases expression

trovafloxacin results in decreased expression of ECHDC3 mRNA

NCBI chr17:76,980,112...77,002,934
Ensembl chr17:72,070,668...72,093,516

G

enoyl-CoA delta isomerase 1

decreases expression

trovafloxacin results in decreased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,456,563...13,470,061

G

epithelial cell transforming 2

decreases expression

trovafloxacin results in decreased expression of ECT2 mRNA

NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:109,975,813...110,037,911

G

ectodysplasin A2 receptor

increases expression

trovafloxacin results in increased expression of EDA2R mRNA

NCBI chr X:66,225,557...66,280,674
Ensembl chr X:62,228,229...62,269,268

G

eukaryotic elongation factor-2 kinase

decreases expression

trovafloxacin results in decreased expression of EEF2K mRNA

NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:175,393,154...175,455,164

G

eukaryotic elongation factor 2 lysine methyltransferase

decreases expression

trovafloxacin results in decreased expression of EEF2KMT mRNA

NCBI chr10:10,843,429...10,853,800
Ensembl chr10:10,336,974...10,347,039

G

EF-hand calcium binding domain 11

decreases expression

trovafloxacin results in decreased expression of EFCAB11 mRNA

NCBI chr 6:124,738,531...124,892,623
Ensembl chr 6:119,008,919...119,162,046

G

EF-hand calcium binding domain 2

decreases expression

trovafloxacin results in decreased expression of EFCAB2 mRNA

NCBI chr13:92,683,182...92,769,939
Ensembl chr13:90,152,185...90,238,218

G

EF-hand calcium binding domain 5

decreases expression

trovafloxacin results in decreased expression of EFCAB5 mRNA

NCBI chr10:61,926,419...62,042,745
Ensembl chr10:61,926,953...62,042,749

G

ephrin B3

increases expression

trovafloxacin results in increased expression of EFNB3 mRNA

NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,274,506...54,280,471

G

EGF-like-domain, multiple 7

decreases expression

trovafloxacin results in decreased expression of EGFL7 mRNA

NCBI chr 3:29,802,481...29,814,966
Ensembl chr 3:9,407,520...9,416,879

G

epidermal growth factor receptor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

early growth response 3

decreases expression

trovafloxacin results in decreased expression of EGR3 mRNA

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627

G

EI24, autophagy associated transmembrane protein

increases expression

trovafloxacin results in increased expression of EI24 mRNA

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:36,494,289...36,510,571

G

EP300 interacting inhibitor of differentiation 1

increases expression

trovafloxacin results in increased expression of EID1 mRNA

NCBI chr 3:133,376,389...133,378,108
Ensembl chr 3:112,922,668...112,924,752

G

EP300 interacting inhibitor of differentiation 2B

increases expression

trovafloxacin results in increased expression of EID2B mRNA

NCBI chr 1:92,673,119...92,674,899
Ensembl chr 1:83,545,563...83,546,734

G

eukaryotic translation initiation factor 2-alpha kinase 2

increases expression

trovafloxacin results in increased expression of EIF2AK2 mRNA

NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2B subunit beta

decreases expression

trovafloxacin results in decreased expression of EIF2B2 mRNA

NCBI chr 6:110,597,979...110,604,403
Ensembl chr 6:104,866,753...104,873,353

G

eukaryotic translation initiation factor 2 subunit alpha

decreases expression

trovafloxacin results in decreased expression of EIF2S1 mRNA

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 2 subunit beta

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF2S2 mRNA

NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:143,373,686...143,395,432

G

eukaryotic translation initiation factor 3, subunit A

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of EIF3A mRNA

NCBI chr 1:269,888,730...269,925,785
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 3, subunit C

decreases expression

trovafloxacin results in decreased expression of EIF3C mRNA

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:181,134,604...181,152,493

G

eukaryotic translation initiation factor 3, subunit L

decreases expression

trovafloxacin results in decreased expression of EIF3L mRNA

NCBI chr 7:112,522,222...112,544,063
Ensembl chr 7:110,627,107...110,663,614

G

eukaryotic translation initiation factor 4A2

increases expression

trovafloxacin results in increased expression of EIF4A2 mRNA

PMID:24136188 PMID:35537566

NCBI chr11:91,268,730...91,276,738
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases expression

[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein]
trovafloxacin results in decreased expression of EIF4EBP1 mRNA

PMID:33609687 PMID:35537566

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 6

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of EIF6 mRNA

NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:144,325,036...144,331,401

G

elongation factor for RNA polymerase II 2

increases expression

trovafloxacin results in increased expression of ELL2 mRNA

NCBI chr 2:6,910,446...6,990,654
Ensembl chr 2:5,189,971...5,258,781

G

engulfment and cell motility 3

increases expression

trovafloxacin results in increased expression of ELMO3 mRNA

NCBI chr19:50,091,883...50,096,324
Ensembl chr19:33,182,036...33,186,410

G

ELOVL fatty acid elongase 6

decreases expression

trovafloxacin results in decreased expression of ELOVL6 mRNA

NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:218,063,804...218,171,186

G

ER membrane protein complex subunit 1

decreases expression

trovafloxacin results in decreased expression of EMC1 mRNA

NCBI chr 5:156,891,773...156,917,092
Ensembl chr 5:151,608,568...151,633,888

G

essential meiotic structure-specific endonuclease 1

decreases expression

trovafloxacin results in decreased expression of EME1 mRNA

NCBI chr10:80,083,585...80,092,450
Ensembl chr10:79,586,729...79,595,435

G

EMAP like 6

decreases expression

trovafloxacin results in decreased expression of EML6 mRNA

NCBI chr14:107,651,893...108,006,792
Ensembl chr14:103,476,372...103,805,849

G

endonuclease G

decreases expression

trovafloxacin results in decreased expression of ENDOG mRNA

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:13,449,086...13,451,932

G

enolase 3

decreases expression

trovafloxacin results in decreased expression of ENO3 mRNA

NCBI chr10:55,868,880...55,876,099
Ensembl chr10:55,366,975...55,375,921

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

decreases expression

trovafloxacin results in decreased expression of ENPP1 mRNA

NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:20,698,764...20,763,715

G

ectonucleotide pyrophosphatase/phosphodiesterase 6

decreases expression

trovafloxacin results in decreased expression of ENPP6 mRNA

NCBI chr16:51,898,557...52,026,789
Ensembl chr16:45,169,178...45,294,077

G

ectonucleoside triphosphate diphosphohydrolase 1

decreases expression

trovafloxacin results in decreased expression of ENTPD1 mRNA

NCBI chr 1:249,374,810...249,502,310
Ensembl chr 1:239,425,430...239,552,317

G

Eph receptor A2

increases expression

trovafloxacin results in increased expression of EPHA2 mRNA

NCBI chr 5:158,888,629...158,917,100
Ensembl chr 5:153,605,644...153,634,117

G

epoxide hydrolase 1

decreases expression

trovafloxacin results in decreased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235

G

EPM2A glucan phosphatase, laforin

decreases expression

trovafloxacin results in decreased expression of EPM2A mRNA

NCBI chr 1:7,547,369...7,673,449
Ensembl chr 1:5,727,066...5,920,555

G

EPM2A interacting protein 1

increases expression

trovafloxacin results in increased expression of EPM2AIP1 mRNA

NCBI chr 8:120,112,265...120,119,613
Ensembl chr 8:111,233,826...111,241,871

G

glutamyl-prolyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of EPRS1 mRNA

NCBI chr13:99,431,955...99,503,510
Ensembl chr13:96,901,575...96,971,966

G

ERCC excision repair 1, endonuclease non-catalytic subunit

decreases expression

trovafloxacin results in decreased expression of ERCC1 mRNA

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

trovafloxacin results in decreased expression of ERCC6L mRNA

NCBI chr X:71,285,380...71,301,186
Ensembl chr X:67,245,414...67,280,756

G

endoplasmic reticulum-golgi intermediate compartment 1

decreases expression

trovafloxacin results in decreased expression of ERGIC1 mRNA

NCBI chr10:17,035,615...17,131,411
Ensembl chr10:16,531,194...16,626,957

G

endoplasmic reticulum metallopeptidase 1

decreases expression

trovafloxacin results in decreased expression of ERMP1 mRNA

NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:227,387,920...227,436,909

G

endoplasmic reticulum protein 29

decreases expression

trovafloxacin results in decreased expression of ERP29 mRNA

NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376

G

ERBB receptor feedback inhibitor 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ERRFI1 mRNA

NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

trovafloxacin results in decreased expression of ESCO2 mRNA

NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306

G

esterase D

increases expression

trovafloxacin results in increased expression of ESD mRNA

NCBI chr15:56,453,082...56,472,582
Ensembl chr15:50,043,632...50,063,144

G

extra spindle pole bodies like 1, separase

decreases expression

trovafloxacin results in decreased expression of ESPL1 mRNA

NCBI chr 7:135,302,460...135,329,570
Ensembl chr 7:133,424,130...133,450,984

G

estrogen receptor 1

decreases expression

trovafloxacin results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

extended synaptotagmin 1

decreases expression

trovafloxacin results in decreased expression of ESYT1 mRNA

NCBI chr 7:1,513,381...1,530,836
Ensembl chr 7:928,848...946,199

G

extended synaptotagmin 2

decreases expression

trovafloxacin results in decreased expression of ESYT2 mRNA

NCBI chr 6:143,359,870...143,455,600
Ensembl chr 6:137,219,707...137,312,590

G

ETS proto-oncogene 2, transcription factor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ETS2 mRNA

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 3

increases expression

trovafloxacin results in increased expression of ETV3 mRNA

NCBI chr 2:175,263,389...175,278,217
Ensembl chr 2:172,965,588...172,980,314

G

ecotropic viral integration site 2A

increases expression

trovafloxacin results in increased expression of EVI2A mRNA

NCBI chr10:64,983,727...64,987,627
Ensembl chr10:64,485,200...64,489,843

G

ecotropic viral integration site 5

decreases expression

trovafloxacin results in decreased expression of EVI5 mRNA

NCBI chr14:2,020,524...2,166,593
Ensembl chr14:1,875,647...2,021,678

G

exonuclease 3'-5' domain containing 2

decreases expression

trovafloxacin results in decreased expression of EXD2 mRNA

NCBI chr 6:105,847,931...105,881,780
Ensembl chr 6:100,116,867...100,150,442

G

exostosin-like glycosyltransferase 1

decreases expression

trovafloxacin results in decreased expression of EXTL1 mRNA

NCBI chr 5:151,857,629...151,872,830
Ensembl chr 5:146,573,912...146,589,115

G

EYA transcriptional coactivator and phosphatase 4

decreases expression

trovafloxacin results in decreased expression of EYA4 mRNA

NCBI chr 1:23,991,431...24,235,132
Ensembl chr 1:22,172,275...22,415,976

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

trovafloxacin results in decreased expression of EZH2 mRNA

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor X

decreases expression

trovafloxacin results in decreased expression of F10 mRNA

NCBI chr16:83,170,973...83,190,280
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor XII

increases expression

trovafloxacin results in increased expression of F12 mRNA

NCBI chr17:9,212,819...9,220,664
Ensembl chr17:9,207,683...9,215,530

G

coagulation factor II, thrombin

multiple interactions

[Lipopolysaccharides co-treated with trovafloxacin] results in increased activity of F2 protein

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor VII

decreases expression

trovafloxacin results in decreased expression of F7 mRNA

NCBI chr16:83,191,896...83,202,775
Ensembl chr16:76,489,717...76,500,610

G

fatty acid amide hydrolase

decreases expression

trovafloxacin results in decreased expression of FAAH mRNA

NCBI chr 5:134,716,545...134,735,396
Ensembl chr 5:129,479,824...129,498,677

G

FA core complex associated protein 100

decreases expression

trovafloxacin results in decreased expression of FAAP100 mRNA

NCBI chr10:106,140,820...106,152,500
Ensembl chr10:105,639,414...105,653,494

G

Fas associated factor 1

decreases expression

trovafloxacin results in decreased expression of FAF1 mRNA

NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:124,426,062...124,789,977

G

fumarylacetoacetate hydrolase domain containing 2A

decreases expression

trovafloxacin results in decreased expression of FAHD2A mRNA

NCBI chr 3:135,110,480...135,118,653
Ensembl chr 3:114,655,865...114,665,356

G

family with sequence similarity 120 member C

decreases expression

trovafloxacin results in decreased expression of FAM120C mRNA

NCBI chr X:23,765,089...23,922,059
Ensembl chr X:20,323,381...20,477,275

G

family with sequence similarity 131, member A

decreases expression

trovafloxacin results in decreased expression of FAM131A mRNA

NCBI chr11:93,715,979...93,725,930
Ensembl chr11:80,211,745...80,221,511

G

family with sequence similarity 13, member C

decreases expression

trovafloxacin results in decreased expression of FAM13C mRNA

NCBI chr20:18,064,706...18,186,888
Ensembl chr20:18,065,628...18,187,592

G

family with sequence similarity 171, member A2

decreases expression

trovafloxacin results in decreased expression of FAM171A2 mRNA

NCBI chr10:87,894,049...87,904,213
Ensembl chr10:87,394,007...87,404,053

G

family with sequence similarity 171, member B

decreases expression

trovafloxacin results in decreased expression of FAM171B mRNA

NCBI chr 3:89,337,566...89,392,973
Ensembl chr 3:68,930,822...68,986,127

G

family with sequence similarity 222, member B

increases expression

trovafloxacin results in increased expression of FAM222B mRNA

NCBI chr10:62,986,571...63,052,350
Ensembl chr10:62,986,571...63,052,350

G

family with sequence similarity 83, member D

decreases expression

trovafloxacin results in decreased expression of FAM83D mRNA

NCBI chr 3:167,841,748...167,861,062
Ensembl chr 3:147,421,908...147,441,192

G

family with sequence similarity 83, member H

increases expression

trovafloxacin results in increased expression of FAM83H mRNA

NCBI chr 7:109,597,129...109,605,317
Ensembl chr 7:107,716,431...107,728,672

G

family with sequence similarity 98, member A

decreases expression

trovafloxacin results in decreased expression of FAM98A mRNA

NCBI chr 6:25,626,108...25,640,767
Ensembl chr 6:19,874,071...19,888,742

G

FA complementation group A

decreases expression

trovafloxacin results in decreased expression of FANCA mRNA

NCBI chr19:68,210,562...68,271,080
Ensembl chr19:51,304,021...51,362,527

G

FA complementation group B

decreases expression

trovafloxacin results in decreased expression of FANCB mRNA

NCBI chr X:33,035,387...33,051,993
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group C

decreases expression

trovafloxacin results in decreased expression of FANCC mRNA

NCBI chr17:1,686,374...1,818,672
Ensembl chr17:1,681,324...1,829,376

G

FA complementation group D2

decreases expression

trovafloxacin results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group I

decreases expression

trovafloxacin results in decreased expression of FANCI mRNA

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:133,327,297...133,383,640

G

fatty acid synthase

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FASN mRNA
trovafloxacin results in decreased expression of FASN mRNA

PMID:18930950 PMID:24136188

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

F-box and leucine-rich repeat protein 12

increases expression

trovafloxacin results in increased expression of FBXL12 mRNA

NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:19,160,352...19,183,607

G

F-box protein 15

decreases expression

trovafloxacin results in decreased expression of FBXO15 mRNA

NCBI chr18:80,594,444...80,909,549
Ensembl chr18:78,319,534...78,390,765

G

F-box protein 33

increases expression

trovafloxacin results in increased expression of FBXO33 mRNA

NCBI chr 6:82,635,509...82,669,441
Ensembl chr 6:76,900,631...76,932,669

G

F-box protein 36

increases expression

trovafloxacin results in increased expression of FBXO36 mRNA

NCBI chr 9:86,042,522...86,107,220
Ensembl chr 9:86,040,862...86,107,229

G

F-box protein 48

decreases expression

trovafloxacin results in decreased expression of FBXO48 mRNA

NCBI chr14:95,582,493...95,583,950
Ensembl chr14:91,380,857...91,382,314

G

F-box protein 5

decreases expression

trovafloxacin results in decreased expression of FBXO5 mRNA

NCBI chr 1:44,601,412...44,607,781
Ensembl chr 1:42,196,068...42,202,437

G

f-box protein 9

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FBXO9 mRNA

NCBI chr 8:87,838,787...87,864,362
Ensembl chr 8:78,958,483...78,983,949

G

F-box and WD repeat domain containing 10

decreases expression

trovafloxacin results in decreased expression of FBXW10 mRNA

NCBI chr10:48,012,555...48,051,136
Ensembl chr10:47,486,297...47,551,907

G

Fcf1 rRNA-processing protein

increases expression

trovafloxacin results in increased expression of FCF1 mRNA

NCBI chr 6:110,348,854...110,360,715
Ensembl chr 6:104,617,770...104,629,643

G

Fc gamma receptor 2B

decreases expression

trovafloxacin results in decreased expression of FCGR2B mRNA

NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778

G

FCH and double SH3 domains 1

increases expression

trovafloxacin results in increased expression of FCHSD1 mRNA

NCBI chr18:30,043,466...30,056,326
Ensembl chr18:29,793,899...29,804,466

G

ferredoxin reductase

decreases expression

trovafloxacin results in decreased expression of FDXR mRNA

NCBI chr10:101,006,845...101,015,582
Ensembl chr10:100,507,865...100,516,658

G

free fatty acid receptor 4

decreases expression

trovafloxacin results in decreased expression of FFAR4 mRNA

NCBI chr 1:245,286,009...245,304,029
Ensembl chr 1:235,873,576...235,891,597

G

fibrinogen alpha chain

multiple interactions

[Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of FGA protein

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528

G

FYVE, RhoGEF and PH domain containing 4

decreases expression

trovafloxacin results in decreased expression of FGD4 mRNA

NCBI chr11:97,904,182...98,055,190
Ensembl chr11:84,399,816...84,546,972

G

fibroblast growth factor 22

increases expression

trovafloxacin results in increased expression of FGF22 mRNA

NCBI chr 7:10,598,254...10,600,945
Ensembl chr 7:9,948,071...9,950,486

G

fidgetin-like 2

increases expression

trovafloxacin results in increased expression of FIGNL2 mRNA

NCBI chr 7:134,038,734...134,066,626
Ensembl chr 7:132,162,390...132,164,336

G

filamin A interacting protein 1-like

decreases expression

trovafloxacin results in decreased expression of FILIP1L mRNA

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:42,940,467...43,177,415

G

four-jointed box kinase 1

increases expression

trovafloxacin results in increased expression of ANKHD1-EIF4EBP3 mRNA

NCBI chr 3:109,229,223...109,231,324
Ensembl chr 3:88,774,220...88,776,321

G

FKBP prolyl isomerase 11

decreases expression

trovafloxacin results in decreased expression of FKBP11 mRNA

NCBI chr 7:131,750,828...131,757,784
Ensembl chr 7:129,871,870...129,875,303

G

FKBP prolyl isomerase family member 15

decreases expression

trovafloxacin results in decreased expression of FKBP15 mRNA

NCBI chr 5:80,766,356...80,830,622
Ensembl chr 5:75,750,787...75,814,990

G

FKBP prolyl isomerase 4

decreases expression

trovafloxacin results in decreased expression of FKBP4 mRNA

NCBI chr 4:163,389,464...163,397,918
Ensembl chr 4:161,703,379...161,711,833

G

FKBP prolyl isomerase 8

decreases expression

trovafloxacin results in decreased expression of FKBP8 mRNA

NCBI chr16:18,929,581...18,936,621
Ensembl chr16:18,893,576...18,902,612

G

FKBP prolyl isomerase like

decreases expression

trovafloxacin results in decreased expression of FKBPL mRNA

NCBI chr20:4,104,457...4,105,927
Ensembl chr20:4,099,806...4,101,368

G

fibronectin leucine rich transmembrane protein 2

increases expression

trovafloxacin results in increased expression of FLRT2 mRNA

NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:114,777,599...114,872,785

G

flavin containing dimethylaniline monoxygenase 3

increases expression

trovafloxacin results in increased expression of FMO3 mRNA

NCBI chr13:77,838,899...77,868,869
Ensembl chr13:75,309,374...75,328,028

G

flavin containing dimethylaniline monoxygenase 5

decreases expression

trovafloxacin results in decreased expression of FMO5 mRNA

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:185,222,204...185,249,693

G

formin binding protein 1-like

increases expression

trovafloxacin results in increased expression of FNBP1L mRNA

NCBI chr 2:213,331,871...213,432,821
Ensembl chr 2:210,647,246...210,738,455

G

formin binding protein 4

increases expression

trovafloxacin results in increased expression of FNBP4 mRNA

NCBI chr 3:97,188,852...97,218,916
Ensembl chr 3:76,733,027...76,763,079

G

fibronectin type III domain containing 8

increases expression

trovafloxacin results in increased expression of FNDC8 mRNA

NCBI chr10:68,323,500...68,331,638
Ensembl chr10:67,825,952...67,834,090

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of FOS mRNA
trovafloxacin results in increased expression of FOS mRNA

PMID:18930950 PMID:35537566

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

trovafloxacin results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

trovafloxacin results in increased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box M1

decreases expression

trovafloxacin results in decreased expression of FOXM1 mRNA

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684

G

FRAT regulator of WNT signaling pathway 2

decreases expression

trovafloxacin results in decreased expression of FRAT2 mRNA

NCBI chr 1:250,603,450...250,605,779
Ensembl chr 1:240,654,137...240,656,517

G

fibroblast growth factor receptor substrate 3

increases expression

trovafloxacin results in increased expression of FRS3 mRNA

NCBI chr 9:20,786,096...20,800,905
Ensembl chr 9:13,288,667...13,295,382

G

FRY microtubule binding protein

decreases expression

trovafloxacin results in decreased expression of FRY mRNA

NCBI chr12:9,530,360...9,773,391
Ensembl chr12:4,493,891...4,799,116

G

far upstream element binding protein 1

increases expression

trovafloxacin results in increased expression of FUBP1 mRNA

NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602

G

fucosyltransferase 10

decreases expression

trovafloxacin results in decreased expression of FUT10 mRNA

NCBI chr16:67,571,828...67,661,814
Ensembl chr16:60,877,952...60,958,683

G

fucosyltransferase 4

increases expression

trovafloxacin results in increased expression of FUT4 mRNA

NCBI chr 8:19,868,178...19,872,139
Ensembl chr 8:11,586,721...11,590,682

G

fucosyltransferase 8

decreases expression

trovafloxacin results in decreased expression of FUT8 mRNA

NCBI chr 6:101,682,354...101,909,784
Ensembl chr 6:95,949,991...96,176,677

G

fuzzy planar cell polarity protein

decreases expression

trovafloxacin results in decreased expression of FUZ mRNA

NCBI chr 1:104,515,782...104,524,591
Ensembl chr 1:95,379,587...95,384,530

G

frizzled class receptor 7

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of FZD7 mRNA

NCBI chr 9:68,425,538...68,428,357
Ensembl chr 9:60,930,875...60,935,781

G

frizzled class receptor 8

increases expression

trovafloxacin results in increased expression of FZD8 mRNA

NCBI chr17:62,007,849...62,015,485
Ensembl chr17:57,314,450...57,320,650

G

G2/M-phase specific E3 ubiquitin protein ligase

decreases expression

trovafloxacin results in decreased expression of G2E3 mRNA

NCBI chr 6:74,498,801...74,530,703
Ensembl chr 6:68,764,185...68,793,924

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

decreases expression

trovafloxacin results in decreased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801

G

alpha glucosidase

decreases expression

trovafloxacin results in decreased expression of GAA mRNA

NCBI chr10:105,028,106...105,045,365
Ensembl chr10:104,529,747...104,546,836

G

GABA type A receptor associated protein like 1

multiple interactions
increases expression

[trovafloxacin co-treated with TNF protein] results in increased expression of GABARAPL1 mRNA
trovafloxacin results in increased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:162,980,249...162,989,450

G

GABA type A receptor associated protein like 2

multiple interactions
increases expression

TNF protein inhibits the reaction [trovafloxacin results in increased expression of GABARAPL2 mRNA]

NCBI chr19:56,819,826...56,830,662
Ensembl chr19:39,910,534...39,924,628

G

growth arrest and DNA-damage-inducible, alpha

decreases expression

trovafloxacin results in decreased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

increases expression

trovafloxacin results in increased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

decreases expression
increases expression

trovafloxacin results in decreased expression of GADD45G mRNA
trovafloxacin results in increased expression of GADD45G mRNA

PMID:24136188 PMID:35537566

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,376,839...13,378,610

G

galactose-3-O-sulfotransferase 4

increases expression

trovafloxacin results in increased expression of GAL3ST4 mRNA

NCBI chr12:22,381,576...22,390,566
Ensembl chr12:17,267,963...17,276,833

G

galactosylceramidase

decreases expression

trovafloxacin results in decreased expression of GALC mRNA

NCBI chr 6:123,182,636...123,252,024
Ensembl chr 6:117,452,895...117,515,830

G

gigaxonin

increases expression

trovafloxacin results in increased expression of GAN mRNA

NCBI chr19:62,116,600...62,173,879
Ensembl chr19:45,207,184...45,254,107

G

glucosidase, alpha; neutral C

decreases expression

trovafloxacin results in decreased expression of GANC mRNA

NCBI chr 3:127,807,132...127,858,995
Ensembl chr 3:107,353,369...107,405,241

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

trovafloxacin results in decreased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

increases expression

trovafloxacin results in increased expression of GAPDHS mRNA

NCBI chr 1:95,106,516...95,125,918
Ensembl chr 1:85,979,098...85,993,640

G

glycyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of GARS1 mRNA

NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:84,171,596...84,212,609

G

growth arrest-specific 2

decreases expression

trovafloxacin results in decreased expression of GAS2 mRNA

NCBI chr 1:110,587,952...110,721,572
Ensembl chr 1:101,482,591...101,582,619

G

growth arrest specific 5

increases expression

trovafloxacin results in increased expression of GAS5 mRNA

NCBI chr13:75,836,963...75,840,284

G

growth arrest specific 8

increases expression

trovafloxacin results in increased expression of GAS8 mRNA

NCBI chr19:68,461,280...68,480,810
Ensembl chr19:51,552,816...51,572,305

G

guanylate binding protein 1

increases expression

trovafloxacin results in increased expression of GBP2B mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

guanylate binding protein 2

increases expression

trovafloxacin results in increased expression of GBP2 mRNA

NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:231,332,284...231,348,571

G

guanylate binding protein family member 6

increases expression

trovafloxacin results in increased expression of GBP6 mRNA

NCBI chr14:5,034,999...5,062,023
Ensembl chr14:4,730,453...4,839,062
Ensembl chr14:4,730,453...4,839,062

G

guanylate binding protein 7

increases expression

trovafloxacin results in increased expression of GBP7 mRNA

NCBI chr 2:233,948,774...233,970,532
Ensembl chr 2:231,275,640...231,297,278

G

glycine C-acetyltransferase

decreases expression

trovafloxacin results in decreased expression of GCAT mRNA

NCBI chr 7:112,475,572...112,481,920
Ensembl chr 7:110,595,091...110,601,473

G

glucagon receptor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCGR mRNA

NCBI chr10:106,306,803...106,314,970
Ensembl chr10:105,808,473...105,816,640

G

glutamate-cysteine ligase, catalytic subunit

decreases expression
multiple interactions

trovafloxacin results in decreased expression of GCLC mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GCLC mRNA

PMID:18930950 PMID:24136188

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

GEN1 Holliday junction 5' flap endonuclease

decreases expression

trovafloxacin results in decreased expression of GEN1 mRNA

NCBI chr 6:39,666,675...39,697,480
Ensembl chr 6:33,948,206...33,978,401

G

guided entry of tail-anchored proteins factor 1

increases expression

trovafloxacin results in increased expression of WRB mRNA

NCBI chr11:48,915,298...48,929,235
Ensembl chr11:35,445,815...35,459,973

G

G elongation factor, mitochondrial 1

decreases expression

trovafloxacin results in decreased expression of GFM1 mRNA

NCBI chr 2:154,010,601...154,055,523
Ensembl chr 2:151,700,564...151,745,471

G

Gfo/Idh/MocA-like oxidoreductase domain containing 2

increases expression

trovafloxacin results in increased expression of GFOD2 mRNA

NCBI chr19:50,508,626...50,556,945
Ensembl chr19:33,604,187...33,647,004

G

gamma-glutamyl carboxylase

decreases expression

trovafloxacin results in decreased expression of GGCX mRNA

NCBI chr 4:106,027,918...106,043,653
Ensembl chr 4:104,469,765...104,487,063

G

GINS complex subunit 2

decreases expression

trovafloxacin results in decreased expression of GINS2 mRNA

NCBI chr19:65,535,492...65,548,270
Ensembl chr19:48,626,770...48,639,339

G

GIPC PDZ domain containing family, member 1

decreases expression

trovafloxacin results in decreased expression of GIPC1 mRNA

NCBI chr19:41,380,125...41,392,078
Ensembl chr19:24,453,123...24,486,997

G

gap junction protein, alpha 1

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GJA1 mRNA
trovafloxacin results in increased expression of GJA1 mRNA

PMID:18930950 PMID:35537566

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

GLIS family zinc finger 2

increases expression

trovafloxacin results in increased expression of GLIS2 mRNA

NCBI chr10:11,457,594...11,484,948
Ensembl chr10:10,951,371...10,971,578

G

glycosylated lysosomal membrane protein

decreases expression

trovafloxacin results in decreased expression of GLMP mRNA

NCBI chr 2:176,092,098...176,095,688
Ensembl chr 2:173,794,255...173,799,960

G

glucagon-like peptide 2 receptor

increases expression

trovafloxacin results in increased expression of GLP2R mRNA

NCBI chr10:52,901,707...52,964,961
Ensembl chr10:52,402,748...52,466,012

G

glutaredoxin 3

decreases expression

trovafloxacin results in decreased expression of GLRX3 mRNA

NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010

G

glutaminase 2

decreases expression

trovafloxacin results in decreased expression of GLS2 mRNA

NCBI chr 7:1,201,757...1,218,014
Ensembl chr 7:617,288...633,426

G

glycine-N-acyltransferase

increases expression

trovafloxacin results in increased expression of GLYAT mRNA

NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:209,704,268...209,724,942

G

glia maturation factor, beta

increases expression

trovafloxacin results in increased expression of GMFB mRNA

NCBI chr15:22,549,705...22,560,125
Ensembl chr15:20,067,263...20,080,331

G

G protein subunit alpha transducin 2

decreases expression

trovafloxacin results in decreased expression of GNAT2 mRNA

NCBI chr 2:198,414,568...198,431,532
Ensembl chr 2:195,726,762...195,735,866

G

G protein nucleolar 3

increases expression

trovafloxacin results in increased expression of GNL3 mRNA

NCBI chr16:6,213,844...6,220,029
Ensembl chr16:6,207,402...6,213,392

G

glyceronephosphate O-acyltransferase

decreases expression

trovafloxacin results in decreased expression of GNPAT mRNA

NCBI chr19:69,719,707...69,746,244
Ensembl chr19:52,822,319...52,852,361

G

glucosamine-phosphate N-acetyltransferase 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GNPNAT1 mRNA

NCBI chr15:21,076,129...21,088,526
Ensembl chr15:18,596,442...18,608,739

G

N-acetylglucosamine-1-phosphate transferase subunit gamma

decreases expression

trovafloxacin results in decreased expression of GNPTG mRNA

NCBI chr10:14,756,685...14,761,636
Ensembl chr10:14,251,136...14,257,096

G

golgin A2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA2 mRNA

NCBI chr 3:35,981,783...36,002,023
Ensembl chr 3:15,584,039...15,604,279

G

golgin A4

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of GOLGA4 mRNA

NCBI chr 8:127,085,830...127,163,227

G

glycosylphosphatidylinositol anchor attachment 1

decreases expression

trovafloxacin results in decreased expression of GPAA1 mRNA

NCBI chr 7:109,932,556...109,936,139
Ensembl chr 7:108,051,861...108,055,484

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression

trovafloxacin results in decreased expression of GPAM mRNA

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:254,106,331...254,142,639

G

glycerol-3-phosphate acyltransferase 3

decreases expression

trovafloxacin results in decreased expression of AGPAT9 mRNA

NCBI chr14:9,018,762...9,072,552
Ensembl chr14:8,714,373...8,766,490

G

G patch domain containing 3

increases expression

trovafloxacin results in increased expression of GPATCH3 mRNA

NCBI chr 5:151,083,970...151,093,382
Ensembl chr 5:145,800,111...145,809,250

G

glypican 1

increases expression

trovafloxacin results in increased expression of GPC1 mRNA

NCBI chr 9:100,843,645...100,871,458
Ensembl chr 9:93,396,234...93,424,047

G

gephyrin

decreases expression

trovafloxacin results in decreased expression of GPHN mRNA

NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:96,892,148...97,483,612

G

glycosylphosphatidylinositol specific phospholipase D1

increases expression

trovafloxacin results in increased expression of GPLD1 mRNA

NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,084,617...40,126,939

G

G protein-coupled receptor 155

decreases expression

trovafloxacin results in decreased expression of GPR155 mRNA

NCBI chr 3:78,623,931...78,677,803
Ensembl chr 3:58,216,423...58,270,275

G

G protein-coupled receptor 160

decreases expression

trovafloxacin results in decreased expression of GPR160 mRNA

NCBI chr 2:114,414,084...114,491,590
Ensembl chr 2:112,484,935...112,563,148

G

G protein-coupled receptor 17

increases expression

trovafloxacin results in increased expression of GPR17 mRNA

NCBI chr18:23,850,460...23,857,381
Ensembl chr18:23,577,242...23,582,966

G

G protein-coupled receptor 176

decreases expression

trovafloxacin results in decreased expression of GPR176 mRNA

NCBI chr 3:125,690,750...125,791,172
Ensembl chr 3:105,236,795...105,337,226

G

G protein-coupled receptor 19

decreases expression

trovafloxacin results in decreased expression of GPR19 mRNA

NCBI chr 4:169,442,278...169,468,805
Ensembl chr 4:167,710,666...167,741,036

G

G protein-coupled receptor 34

decreases expression

trovafloxacin results in decreased expression of GPR34 mRNA

NCBI chr X:11,777,667...11,786,640
Ensembl chr X:9,104,565...9,148,601

G

G protein-coupled receptor 35

decreases expression

trovafloxacin results in decreased expression of GPR35 mRNA

NCBI chr 9:100,974,580...100,995,330
Ensembl chr 9:93,527,127...93,539,299

G

G-protein coupled receptor 65

decreases expression

trovafloxacin results in decreased expression of GPR65 mRNA

NCBI chr 6:123,245,534...123,262,758
Ensembl chr 6:117,515,648...117,536,512

G

G-protein signaling modulator 2

decreases expression

trovafloxacin results in decreased expression of GPSM2 mRNA

NCBI chr 2:199,015,250...199,063,788
Ensembl chr 2:196,327,149...196,375,154

G

glutamic--pyruvic transaminase 2

decreases expression

trovafloxacin results in decreased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:21,517,621...21,560,610

G

grainyhead-like transcription factor 1

increases expression

trovafloxacin results in increased expression of GRHL1 mRNA

NCBI chr 6:46,935,947...46,986,126
Ensembl chr 6:41,207,348...41,254,301

G

glutamate ionotropic receptor NMDA type subunit 3B

increases expression

trovafloxacin results in increased expression of GRIN3B mRNA

NCBI chr 7:10,381,495...10,387,817
Ensembl chr 7:9,730,862...9,737,183

G

glutamate-rich WD repeat containing 1

increases expression

trovafloxacin results in increased expression of GRWD1 mRNA

NCBI chr 1:105,437,708...105,443,410
Ensembl chr 1:96,301,261...96,307,201

G

glutathione-disulfide reductase

decreases expression

trovafloxacin results in decreased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

decreases expression

trovafloxacin results in decreased expression of GSS mRNA

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 3

decreases expression

trovafloxacin results in decreased expression of GSTA3 mRNA

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:23,658,574...23,684,240

G

general transcription factor III A

decreases expression

trovafloxacin results in decreased expression of GTF3A mRNA

NCBI chr12:13,250,643...13,258,587
Ensembl chr12:8,136,747...8,144,690

G

GTP binding protein 2

decreases expression

trovafloxacin results in decreased expression of GTPBP2 mRNA

NCBI chr 9:22,311,532...22,321,405
Ensembl chr 9:14,813,964...14,823,241

G

GTP binding protein 6 (putative)

increases expression

trovafloxacin results in increased expression of GTPBP6 mRNA

NCBI chr12:52,234,646...52,238,578
Ensembl chr12:46,574,435...46,578,873

G

G-2 and S-phase expressed 1

increases expression

trovafloxacin results in increased expression of GTSE1 mRNA

NCBI chr 7:118,829,793...118,846,662
Ensembl chr 7:116,950,053...116,966,806

G

GTPase, very large interferon inducible 1

increases expression

trovafloxacin results in increased expression of GVIN2 mRNA

NCBI chr 1:169,689,178...169,718,522
Ensembl chr 1:160,277,126...160,306,331

G

H1.0 linker histone

decreases expression

trovafloxacin results in decreased expression of H1F0 mRNA

NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694

G

H1.10 linker histone

decreases expression

trovafloxacin results in decreased expression of H1F10 mRNA

NCBI chr 4:121,997,834...121,998,897
Ensembl chr 4:120,440,870...120,441,448

G

H1.2 linker histone, cluster member

decreases expression

trovafloxacin results in decreased expression of H1F2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,388,477...41,392,635

G

H1.4 linker histone, cluster member

decreases expression

trovafloxacin results in decreased expression of H1F4 mRNA

NCBI chr17:41,914,425...41,915,206
Ensembl chr17:41,486,560...41,487,403

G

H1.5 linker histone, cluster member

decreases expression

trovafloxacin results in decreased expression of H1F5 mRNA

NCBI chr17:47,421,875...47,422,905
Ensembl chr17:42,726,127...42,769,160

G

H2A clustered histone 10

decreases expression

trovafloxacin results in decreased expression of H2AC10 mRNA

NCBI chr17:41,998,567...41,999,055
Ensembl chr17:41,570,273...41,571,049

G

H2A clustered histone 4

decreases expression

trovafloxacin results in decreased expression of H2AC4 mRNA

NCBI chr17:47,495,624...47,496,127
Ensembl chr17:42,799,652...42,800,381

G

H2A.X variant histone

multiple interactions
decreases expression
increases phosphorylation
increases expression

[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [trovafloxacin results in increased expression of H2AX protein modified form]; TNF protein promotes the reaction [trovafloxacin results in increased expression of H2AX protein modified form]
trovafloxacin results in decreased expression of H2AX mRNA
trovafloxacin results in increased phosphorylation of H2AX protein

PMID:24817034 PMID:25748550 PMID:35537566

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H2B clustered histone 18

decreases expression

trovafloxacin results in decreased expression of H2BC18 mRNA

NCBI chr 2:186,527,197...186,531,634
Ensembl chr 2:183,838,334...183,841,529

G

H2B clustered histone 3

decreases expression

trovafloxacin results in decreased expression of H2BC3 mRNA

NCBI chr17:41,807,913...41,808,543

G

H2B clustered histone 6

decreases expression

trovafloxacin results in decreased expression of H2BC6 mRNA

NCBI chr17:41,948,813...41,949,276

G

H2B clustered histone 8

decreases expression

trovafloxacin results in decreased expression of H2BC8 mRNA

NCBI chr17:47,404,405...47,405,155

G

H2B clustered histone 9

decreases expression

trovafloxacin results in decreased expression of H2BC9 mRNA

NCBI chr17:47,166,372...47,174,369

G

histone H4C like 1

decreases expression

trovafloxacin results in decreased expression of H4C6 mRNA

NCBI chr17:41,796,600...41,860,389

G

H1.3 linker histone, cluster member

decreases expression

trovafloxacin results in decreased expression of H1F3 mRNA

NCBI chr17:41,979,562...41,980,341
Ensembl chr17:41,529,667...41,552,334

G

3-hydroxyacyl-CoA dehydratase 3

decreases expression

trovafloxacin results in decreased expression of HACD3 mRNA

NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:65,501,240...65,538,507

G

3-hydroxyacyl-CoA dehydratase 4

decreases expression

trovafloxacin results in decreased expression of HACD4 mRNA

NCBI chr 5:107,935,514...107,961,271
Ensembl chr 5:102,887,588...102,915,338

G

2-hydroxyacyl-CoA lyase 1

increases expression
decreases expression

trovafloxacin results in increased expression of HACL1 mRNA
trovafloxacin results in decreased expression of HACL1 mRNA

PMID:24136188 PMID:35537566

NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,824,906...6,863,027

G

hydroxyacid oxidase 2

increases expression

trovafloxacin results in increased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:186,200,504...186,224,425

G

histone H3 associated protein kinase

decreases expression

trovafloxacin results in decreased expression of GSG2 mRNA

NCBI chr10:58,246,244...58,249,031
Ensembl chr10:57,747,573...57,750,512

G

HAUS augmin-like complex, subunit 4

decreases expression

trovafloxacin results in decreased expression of HAUS4 mRNA

NCBI chr15:31,964,555...31,976,853
Ensembl chr15:27,994,532...28,005,938

G

HAUS augmin-like complex, subunit 5

decreases expression

trovafloxacin results in decreased expression of HAUS5 mRNA

NCBI chr 1:95,039,800...95,050,778
Ensembl chr 1:85,912,374...85,923,337

G

heparin-binding EGF-like growth factor

increases expression

trovafloxacin results in increased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2

decreases expression

trovafloxacin results in decreased expression of HCN2 mRNA

NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:9,970,368...9,988,841

G

haloacid dehalogenase-like hydrolase domain containing 3

increases expression

trovafloxacin results in increased expression of HDHD3 mRNA

NCBI chr 5:80,966,878...80,970,345
Ensembl chr 5:75,946,013...75,955,266

G

high density lipoprotein binding protein

decreases expression

trovafloxacin results in decreased expression of HDLBP mRNA

NCBI chr 9:101,395,491...101,465,446
Ensembl chr 9:93,949,913...94,018,048

G

HemK methyltransferase family member 1

decreases expression

trovafloxacin results in decreased expression of HEMK1 mRNA

NCBI chr 8:116,878,317...116,889,342
Ensembl chr 8:107,999,644...108,010,256

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

decreases expression

trovafloxacin results in decreased expression of HERC1 mRNA

NCBI chr 8:75,796,347...75,965,347
Ensembl chr 8:66,856,935...67,070,312

G

homocysteine inducible ER protein with ubiquitin like domain 1

decreases expression

trovafloxacin results in decreased expression of HERPUD1 mRNA

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,598,417...10,618,424

G

hypoxia inducible lipid droplet-associated

increases expression

trovafloxacin results in increased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:57,871,110...57,874,557

G

huntingtin interacting protein 1 related

decreases expression

trovafloxacin results in decreased expression of HIP1R mRNA

NCBI chr12:38,251,085...38,279,756
Ensembl chr12:32,590,165...32,618,734

G

HIRA interacting protein 3

decreases expression

trovafloxacin results in decreased expression of HIRIP3 mRNA

NCBI chr 1:190,903,065...190,905,610
Ensembl chr 1:181,472,056...181,475,079

G

histone cluster 1 H2A family member F

decreases expression

trovafloxacin results in decreased expression of H2AC8 mRNA

NCBI chr17:41,807,261...41,807,653
Ensembl chr17:41,379,404...41,379,796

G

histone cluster 1 H2a family member I like 1

decreases expression

trovafloxacin results in decreased expression of H3C10 mRNA; trovafloxacin results in decreased expression of H3C11 mRNA; trovafloxacin results in decreased expression of H3C6 mRNA

NCBI chr17:41,996,216...41,997,128
Ensembl chr17:41,568,471...41,569,109

G

histone cluster 1, H2bc

decreases expression

trovafloxacin results in decreased expression of H2BC4 mRNA

NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642

G

histone cluster 1 H4 family member B

decreases expression

trovafloxacin results in decreased expression of H4C9 mRNA

NCBI chr17:47,176,246...47,180,690
Ensembl chr17:42,480,313...42,485,370

G

histone cluster 1, H4m

decreases expression

trovafloxacin results in decreased expression of H4C1 mRNA

NCBI chr17:47,393,764...47,394,168
Ensembl chr17:42,698,025...42,698,958

G

helicase-like transcription factor

decreases expression

trovafloxacin results in decreased expression of HLTF mRNA

NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:102,549,724...102,609,327

G

high mobility group AT-hook 2

increases expression

trovafloxacin results in increased expression of HMGA2 mRNA

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 2

decreases expression

trovafloxacin results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

high mobility group box 3

decreases expression

trovafloxacin results in decreased expression of HMGB3 mRNA

NCBI chr X:154,341,106...154,346,087
Ensembl chr X:149,296,375...149,301,292

G

high mobility group nucleosomal binding domain 3

decreases expression

trovafloxacin results in decreased expression of HMGN3 mRNA

NCBI chr 8:92,902,555...92,939,980
Ensembl chr 8:84,022,495...84,062,976

G

high mobility group nucleosome binding domain 5

decreases expression

trovafloxacin results in decreased expression of HMGN5 mRNA

NCBI chr X:78,161,439...78,170,613
Ensembl chr X:74,085,875...74,094,441
Ensembl chr 1:74,085,875...74,094,441

G

hyaluronan-mediated motility receptor

decreases expression

trovafloxacin results in decreased expression of HMMR mRNA

NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A1

increases expression

trovafloxacin results in increased expression of HNRNPA1 mRNA

NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein D-like

increases expression

trovafloxacin results in increased expression of HNRNPDL mRNA

NCBI chr14:9,861,716...9,867,945
Ensembl chr14:9,557,425...9,562,506

G

heterogeneous nuclear ribonucleoprotein F

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of HNRNPF mRNA

NCBI chr 4:152,755,668...152,776,867
Ensembl chr 4:151,083,062...151,109,038

G

heterogeneous nuclear ribonucleoprotein L

increases expression

trovafloxacin results in increased expression of HNRNPL mRNA

NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:84,100,879...84,111,553

G

homeo box B5

decreases expression

trovafloxacin results in decreased expression of HOXB5 mRNA

NCBI chr10:81,765,911...81,768,119
Ensembl chr10:81,269,372...81,271,580

G

homeo box B8

increases expression

trovafloxacin results in increased expression of HOXB8 mRNA

NCBI chr10:81,745,430...81,747,181
Ensembl chr10:81,248,887...81,250,638

G

haptoglobin

decreases expression

trovafloxacin results in decreased expression of HP mRNA

NCBI chr19:54,449,151...54,453,701
Ensembl chr19:37,539,627...37,544,523

G

heparan sulfate-glucosamine 3-sulfotransferase 3B1

decreases expression

trovafloxacin results in decreased expression of HS3ST3B1 mRNA

NCBI chr10:49,060,693...49,093,185
Ensembl chr10:48,561,473...48,593,970

G

heat shock protein family B (small) member 6

decreases expression

trovafloxacin results in decreased expression of HSPB6 mRNA

NCBI chr 1:94,934,372...94,936,516
Ensembl chr 1:85,806,146...85,809,071

G

heat shock protein family B (small) member 7

decreases expression

trovafloxacin results in decreased expression of HSPB7 mRNA

NCBI chr 5:159,010,759...159,014,245
Ensembl chr 5:153,727,588...153,731,266

G

heat shock protein family H (Hsp110) member 1

decreases expression

trovafloxacin results in decreased expression of HSPH1 mRNA

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:5,390,922...5,410,224

G

HIV-1 Tat interactive protein 2

decreases expression

trovafloxacin results in decreased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:99,469,245...99,488,629

G

HtrA serine peptidase 2

decreases expression

trovafloxacin results in decreased expression of HTRA2 mRNA

NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:115,556,916...115,560,095

G

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

decreases expression

trovafloxacin results in decreased expression of HUWE1 mRNA

NCBI chr X:24,350,708...24,480,798
Ensembl chr X:20,873,795...21,001,262

G

hydroxypyruvate isomerase

decreases expression

trovafloxacin results in decreased expression of HYI mRNA

NCBI chr 5:137,179,975...137,182,654
Ensembl chr 5:131,894,598...131,897,251

G

HYLS1, centriolar and ciliogenesis associated

decreases expression

trovafloxacin results in decreased expression of HYLS1 mRNA

NCBI chr 8:42,170,505...42,179,573
Ensembl chr 8:33,912,692...33,921,760

G

isoleucyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of IARS1 mRNA

NCBI chr17:15,147,357...15,193,716
Ensembl chr17:14,940,924...14,987,237

G

isoleucyl-tRNA synthetase 2, mitochondrial

decreases expression

trovafloxacin results in decreased expression of IARS2 mRNA

NCBI chr13:99,363,035...99,397,068
Ensembl chr13:96,831,484...96,865,501

G

intercellular adhesion molecule 1

multiple interactions
increases expression
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ICAM1 mRNA; trovafloxacin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
trovafloxacin results in increased expression of ICAM1 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ICAM1 mRNA
trovafloxacin results in decreased expression of ICAM1 mRNA

PMID:18930950 PMID:32035082 PMID:35537566

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

intercellular adhesion molecule 2

decreases expression

trovafloxacin results in decreased expression of ICAM2 mRNA

NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,308,538...91,315,293

G

intercellular adhesion molecule 4, Landsteiner-Wiener blood group

decreases expression

trovafloxacin results in decreased expression of ICAM4 mRNA

NCBI chr 8:27,842,255...27,843,351
Ensembl chr 8:19,566,075...19,567,171

G

inhibitor of DNA binding 1

increases expression

trovafloxacin results in increased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

insulin degrading enzyme

decreases expression

trovafloxacin results in decreased expression of IDE mRNA

NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440

G

isocitrate dehydrogenase (NADP(+)) 2

decreases expression

trovafloxacin results in decreased expression of IDH2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025

G

immediate early response 3

increases expression

trovafloxacin results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583

G

immediate early response 5-like

decreases expression

trovafloxacin results in decreased expression of IER5L mRNA

NCBI chr 3:34,141,866...34,143,457
Ensembl chr 3:13,744,078...13,745,647

G

interferon-induced protein 35

increases expression

trovafloxacin results in increased expression of IFI35 mRNA

NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

increases expression

trovafloxacin results in increased expression of IFI44 mRNA

NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

increases expression

trovafloxacin results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

trovafloxacin results in increased expression of IFIT2 mRNA

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

trovafloxacin results in increased expression of IFIT3 mRNA

NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:232,114,166...232,119,307

G

interferon induced transmembrane protein 3

increases expression

trovafloxacin results in increased expression of IFITM3 mRNA

NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:196,111,043...196,112,203

G

interferon gamma

multiple interactions

IFNG protein promotes the reaction [[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein]; IFNG protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNG protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IFNG protein]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin

PMID:18930950 PMID:19362101 PMID:19638433

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 1

increases expression
decreases expression
multiple interactions

trovafloxacin results in increased expression of IFRD1 mRNA
trovafloxacin results in decreased expression of IFRD1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IFRD1 mRNA

PMID:18930950 PMID:24136188 PMID:35537566

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:57,269,384...57,288,990

G

interferon-related developmental regulator 2

decreases expression

trovafloxacin results in decreased expression of IFRD2 mRNA

NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:108,260,969...108,266,194

G

intraflagellar transport 140

decreases expression

trovafloxacin results in decreased expression of IFT140 mRNA

NCBI chr10:14,537,134...14,624,926
Ensembl chr10:14,032,648...14,120,433

G

intraflagellar transport 172

decreases expression

trovafloxacin results in decreased expression of IFT172 mRNA

NCBI chr 6:30,801,841...30,841,239
Ensembl chr 6:25,081,980...25,120,860

G

insulin-like growth factor 1

increases expression

trovafloxacin results in increased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2 mRNA binding protein 1

increases expression

trovafloxacin results in increased expression of IGF2BP1 mRNA

NCBI chr10:81,405,021...81,447,814
Ensembl chr10:80,908,076...80,951,129

G

insulin-like growth factor binding protein 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482

G

immunoglobulin mu DNA binding protein 2

increases expression

trovafloxacin results in increased expression of IGHMBP2 mRNA

NCBI chr 1:209,935,922...209,958,570
Ensembl chr 1:200,506,338...200,529,514

G

immunoglobulin superfamily, member 3

increases expression

trovafloxacin results in increased expression of IGSF3 mRNA

NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:188,811,380...188,899,645

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression

trovafloxacin results in decreased expression of IKBKB mRNA

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

G

interleukin 12 receptor subunit beta 2

decreases expression

trovafloxacin results in decreased expression of IL12RB2 mRNA

NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:96,426,842...96,515,289

G

interleukin 15

increases expression

trovafloxacin results in increased expression of IL15 mRNA

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820

G

interleukin 16

decreases expression

trovafloxacin results in decreased expression of IL16 mRNA

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 17 receptor A

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL17RA mRNA

NCBI chr 4:155,339,742...155,362,382
Ensembl chr 4:153,667,534...153,690,174

G

interleukin 18

multiple interactions

IL18 protein results in increased susceptibility to [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5]; trovafloxacin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL18 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein]

PMID:18930950 PMID:19638433

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 binding protein

increases expression

trovafloxacin results in increased expression of IL18BP mRNA

NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:156,372,883...156,374,963

G

interleukin 18 receptor accessory protein

decreases expression

trovafloxacin results in decreased expression of IL18RAP mRNA

NCBI chr 9:50,263,723...50,296,583
Ensembl chr 9:42,768,220...42,800,959

G

interleukin 1 alpha

multiple interactions
increases expression

[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin
trovafloxacin results in increased expression of IL1A mRNA

PMID:19362101 PMID:35537566

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL1B protein]

PMID:10822086 PMID:19638433 PMID:30876886

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 21 receptor

decreases expression

trovafloxacin results in decreased expression of IL21R mRNA

NCBI chr 1:189,598,682...189,626,340
Ensembl chr 1:180,168,097...180,195,522

G

interleukin 27

increases expression

trovafloxacin results in increased expression of IL27 mRNA

NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582

G

interleukin 6

multiple interactions

[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with IL6 protein] results in increased activity of CASP3 protein
trovafloxacin promotes the reaction [TNF protein results in increased expression of IL6 protein]

PMID:19362101 PMID:19638433 PMID:30876886

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

inner mitochondrial membrane peptidase subunit 2

decreases expression

trovafloxacin results in decreased expression of IMMP2L mRNA

NCBI chr 6:63,797,189...64,696,906
Ensembl chr 6:58,070,283...58,969,840

G

inositol monophosphatase 2

decreases expression

trovafloxacin results in decreased expression of IMPA2 mRNA

NCBI chr18:63,104,113...63,135,232
Ensembl chr18:60,834,246...60,865,641

G

internexin neuronal intermediate filament protein, alpha

increases expression

trovafloxacin results in increased expression of INA mRNA

NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:245,896,775...245,908,330

G

inner centromere protein

decreases expression

trovafloxacin results in decreased expression of INCENP mRNA

NCBI chr 1:215,945,558...216,017,247
Ensembl chr 1:206,523,380...206,553,265

G

inka box actin regulator 2

increases expression

trovafloxacin results in increased expression of INKA2 mRNA

NCBI chr 2:195,873,617...195,888,983
Ensembl chr 2:193,185,275...193,200,642

G

integrator complex subunit 6 like

decreases expression

trovafloxacin results in decreased expression of DDX26B mRNA

NCBI chr X:139,295,490...139,363,090
Ensembl chr X:134,258,125...134,309,617

G

inversin

decreases expression

trovafloxacin results in decreased expression of INVS mRNA

NCBI chr 5:67,406,511...67,559,355
Ensembl chr 5:62,610,968...62,763,350

G

inositol hexakisphosphate kinase 2

increases expression

trovafloxacin results in increased expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:109,484,310...109,510,166

G

IQ motif containing D

increases expression

trovafloxacin results in increased expression of IQCD mRNA

NCBI chr12:41,616,107...41,633,244
Ensembl chr12:35,934,716...35,972,523

G

IQ motif containing GTPase activating protein 3

decreases expression

trovafloxacin results in decreased expression of IQGAP3 mRNA

NCBI chr 2:175,840,001...175,881,799
Ensembl chr 2:173,542,110...173,583,956

G

interferon regulatory factor 1

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IRF1 mRNA
trovafloxacin results in decreased expression of IRF1 mRNA

PMID:18930950 PMID:24136188

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166

G

interferon regulatory factor 4

decreases expression

trovafloxacin results in decreased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070

G

interferon regulatory factor 7

increases expression

trovafloxacin results in increased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832

G

immunity-related GTPase M

increases expression

trovafloxacin results in increased expression of IRGM1 mRNA

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578

G

interferon stimulated exonuclease gene 20

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ISG20 mRNA

NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027

G

IST1 factor associated with ESCRT-III

increases expression

trovafloxacin results in increased expression of IST1 mRNA

NCBI chr19:54,558,353...54,580,551
Ensembl chr19:37,648,095...37,670,956

G

inositol-3-phosphate synthase 1

decreases expression

trovafloxacin results in decreased expression of ISYNA1 mRNA

NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,839,145...18,841,979

G

integrin subunit alpha X

decreases expression

trovafloxacin results in decreased expression of ITGAX mRNA

NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:182,719,609...182,740,698

G

integrin subunit beta 5

decreases expression

trovafloxacin results in decreased expression of ITGB5 mRNA

NCBI chr11:80,333,588...80,449,373
Ensembl chr11:66,829,285...66,944,472

G

inositol 1,4,5-trisphosphate receptor, type 1

decreases expression

trovafloxacin results in decreased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

G

inositol 1,4,5-trisphosphate receptor, type 2

decreases expression

trovafloxacin results in decreased expression of ITPR2 mRNA

NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:179,027,281...179,404,164

G

influenza virus NS1A binding protein

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IVNS1ABP mRNA

NCBI chr13:65,977,069...65,996,685
Ensembl chr13:63,427,041...63,446,701

G

IZUMO family member 4

decreases expression

trovafloxacin results in decreased expression of IZUMO4 mRNA

NCBI chr 7:9,657,975...9,661,699
Ensembl chr 7:9,007,280...9,010,032

G

jade family PHD finger 1

decreases expression

trovafloxacin results in decreased expression of JADE1 mRNA

NCBI chr 2:126,471,124...126,524,252
Ensembl chr 2:124,543,286...124,596,354

G

jagged canonical Notch ligand 1

increases expression

trovafloxacin results in increased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 3

decreases expression

trovafloxacin results in decreased expression of JAK3 mRNA

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,386,405...18,398,536

G

junction adhesion molecule like

decreases expression

trovafloxacin results in decreased expression of JAML mRNA

NCBI chr 8:54,281,596...54,313,655
Ensembl chr 8:45,383,495...45,416,565

G

Jun dimerization protein 2

increases expression

trovafloxacin results in increased expression of JDP2 mRNA

NCBI chr 6:110,988,927...111,033,392
Ensembl chr 6:105,261,373...105,301,485

G

JPX transcript, XIST activator

decreases expression

trovafloxacin results in decreased expression of JPX mRNA

NCBI chr X:72,577,163...72,730,887

G

junctional sarcoplasmic reticulum protein 1

increases expression

trovafloxacin results in increased expression of JSRP1 mRNA

NCBI chr 7:9,539,997...9,556,730
Ensembl chr 7:8,901,609...8,906,055

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of JUNB mRNA

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035

G

KAT8 regulatory NSL complex subunit 1-like

decreases expression

trovafloxacin results in decreased expression of KANSL1L mRNA

NCBI chr 9:75,660,865...75,766,730
Ensembl chr 9:68,211,189...68,300,222

G

kelch repeat and BTB domain containing 11

increases expression

trovafloxacin results in increased expression of KBTBD11 mRNA

NCBI chr16:81,318,596...81,340,334
Ensembl chr16:74,615,792...74,637,736

G

kelch repeat and BTB domain containing 6

decreases expression

trovafloxacin results in decreased expression of KBTBD6 mRNA

NCBI chr15:61,257,360...61,259,117
Ensembl chr15:54,848,446...54,850,453

G

kelch repeat and BTB domain containing 8

increases expression

trovafloxacin results in increased expression of KBTBD8 mRNA

NCBI chr 4:129,232,781...129,245,608
Ensembl chr 4:127,676,141...127,687,697

G

potassium voltage-gated channel subfamily A member 3

decreases expression

trovafloxacin results in decreased expression of KCNA3 mRNA

NCBI chr 2:197,320,324...197,322,277
Ensembl chr 2:194,632,196...194,650,138

G

potassium voltage-gated channel subfamily A regulatory beta subunit 2

decreases expression

trovafloxacin results in decreased expression of KCNAB2 mRNA

NCBI chr 5:168,182,228...168,270,760
Ensembl chr 5:162,901,896...162,988,243

G

potassium voltage-gated channel subfamily E regulatory subunit 3

decreases expression

trovafloxacin results in decreased expression of KCNE3 mRNA

NCBI chr 1:163,936,035...163,942,998
Ensembl chr 1:154,523,830...154,532,020

G

potassium calcium-activated channel subfamily N member 4

increases expression

trovafloxacin results in increased expression of KCNN4 mRNA

NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340

G

potassium channel tetramerization domain containing 12b

decreases expression

trovafloxacin results in decreased expression of KCTD12B mRNA

NCBI chr X:20,989,053...21,000,208
Ensembl chr X:17,643,615...17,654,820

G

kinase insert domain receptor

decreases expression

trovafloxacin results in decreased expression of KDR mRNA

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018

G

KH domain containing 4, pre-mRNA splicing factor

increases expression

trovafloxacin results in increased expression of KHDC4 mRNA

NCBI chr 2:174,149,059...174,177,816
Ensembl chr 2:174,149,141...174,177,504

G

ketohexokinase

decreases expression

trovafloxacin results in decreased expression of KHK mRNA

NCBI chr 6:31,165,246...31,175,779
Ensembl chr 6:25,445,300...25,455,717

G

KIAA0232 homolog

increases expression

trovafloxacin results in increased expression of D5ERTD579E mRNA

NCBI chr14:74,094,421...74,159,316
Ensembl chr14:74,094,488...74,159,326

G

kinesin family member 13A

decreases expression

trovafloxacin results in decreased expression of KIF13A mRNA

NCBI chr17:17,972,227...18,154,763
Ensembl chr17:17,766,597...17,943,615

G

kinesin family member 14

decreases expression

trovafloxacin results in decreased expression of KIF14 mRNA

NCBI chr13:50,478,646...50,542,256
Ensembl chr13:47,927,044...47,989,164

G

kinesin family member 15

decreases expression

trovafloxacin results in decreased expression of KIF15 mRNA

NCBI chr 8:131,479,340...131,550,209
Ensembl chr 8:122,601,897...122,672,750

G

kinesin family member 18A

decreases expression

trovafloxacin results in decreased expression of KIF18A mRNA

NCBI chr 3:116,219,007...116,279,378
Ensembl chr 3:95,764,388...95,824,582

G

kinesin family member 18B

decreases expression

trovafloxacin results in decreased expression of KIF18B mRNA

NCBI chr10:88,370,520...88,392,388
Ensembl chr10:87,870,428...87,889,850

G

kinesin family member 20A

decreases expression

trovafloxacin results in decreased expression of KIF20A mRNA

NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 20B

decreases expression

trovafloxacin results in decreased expression of KIF20B mRNA

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:232,428,371...232,483,787

G

kinesin family member 21B

decreases expression

trovafloxacin results in decreased expression of KIF21B mRNA

NCBI chr13:50,127,842...50,177,822
Ensembl chr13:47,576,160...47,626,127

G

kinesin family member 22

decreases expression

trovafloxacin results in decreased expression of KIF22 mRNA

NCBI chr 1:191,065,875...191,080,955
Ensembl chr 1:181,635,183...181,650,401

G

kinesin family member 23

decreases expression

trovafloxacin results in decreased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 24

decreases expression

trovafloxacin results in decreased expression of KIF24 mRNA

NCBI chr 5:61,357,078...61,423,882
Ensembl chr 5:56,561,154...56,628,025

G

kinesin family member 2C

decreases expression

trovafloxacin results in decreased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:130,637,347...130,662,637

G

kinesin family member 4A

decreases expression

trovafloxacin results in decreased expression of KIF4 mRNA

NCBI chr X:69,761,803...69,864,335
Ensembl chr X:65,721,779...65,824,139

G

KIT ligand

increases expression

trovafloxacin results in increased expression of KITL mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 11

decreases expression

trovafloxacin results in decreased expression of KLF11 mRNA

NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:41,285,842...41,297,550

G

KLF transcription factor 4

decreases expression

trovafloxacin results in decreased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 9

increases expression

trovafloxacin results in increased expression of KLF9 mRNA

NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:220,700,108...220,725,037

G

kelch domain containing 8B

increases expression

trovafloxacin results in increased expression of KLHDC8B mRNA

NCBI chr 8:118,020,136...118,025,102
Ensembl chr 8:109,141,594...109,146,918

G

kelch-like family member 12

increases expression

trovafloxacin results in increased expression of KLHL12 mRNA

NCBI chr13:48,451,920...48,485,638
Ensembl chr13:45,899,928...45,933,643

G

kelch-like family member 24

increases expression
decreases expression

trovafloxacin results in increased expression of KLHL24 mRNA
trovafloxacin results in decreased expression of KLHL24 mRNA

PMID:24136188 PMID:35537566

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:80,846,755...80,877,636

G

kelch-like family member 33

decreases expression

trovafloxacin results in decreased expression of KLHL33 mRNA

NCBI chr15:26,579,473...26,589,766
Ensembl chr15:24,105,930...24,114,438

G

kelch-like family, member 42

increases expression

trovafloxacin results in increased expression of KLHL42 mRNA

NCBI chr 4:181,730,343...181,760,899
Ensembl chr 4:180,004,580...180,027,283

G

kinetochore scaffold 1

decreases expression

trovafloxacin results in decreased expression of KNL1 mRNA

NCBI chr 3:126,483,498...126,545,774
Ensembl chr 3:106,029,661...106,091,915

G

kinetochore-localized astrin/SPAG5 binding protein

decreases expression

trovafloxacin results in decreased expression of KNSTRN mRNA

NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:105,800,954...105,820,715

G

kinetochore associated 1

decreases expression

trovafloxacin results in decreased expression of KNTC1 mRNA

NCBI chr12:38,429,925...38,500,564
Ensembl chr12:32,769,020...32,839,561

G

karyopherin subunit alpha 2

decreases expression

trovafloxacin results in decreased expression of KPNA2 mRNA

NCBI chr10:92,433,678...92,445,841
Ensembl chr10:91,933,951...91,946,150

G

karyopherin subunit beta 1

decreases expression

trovafloxacin results in decreased expression of KPNB1 mRNA

NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,145,420...82,174,605

G

kaptin (actin binding protein)

decreases expression

trovafloxacin results in decreased expression of KPTN mRNA

NCBI chr 1:85,936,922...85,937,716

G

keratin 18

decreases expression

trovafloxacin results in decreased expression of KRT18 mRNA

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

kinase suppressor of ras 1

decreases expression

trovafloxacin results in decreased expression of KSR1 mRNA

NCBI chr10:64,459,786...64,596,083
Ensembl chr10:63,961,759...64,098,076

G

L1 cell adhesion molecule

decreases expression

trovafloxacin results in decreased expression of L1CAM mRNA

NCBI chr X:156,748,597...156,775,116
Ensembl chr X:151,597,277...151,623,857

G

trans-L-3-hydroxyproline dehydratase

decreases expression

trovafloxacin results in decreased expression of L3HYPDH mRNA

NCBI chr 6:96,372,243...96,383,039
Ensembl chr 6:90,636,310...90,647,106

G

lactamase, beta 2

decreases expression

trovafloxacin results in decreased expression of LACTB2 mRNA

NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:5,569,067...5,596,429

G

lysosomal protein transmembrane 4 beta

decreases expression

trovafloxacin results in decreased expression of LAPTM4B mRNA

NCBI chr 7:67,319,438...67,362,547
Ensembl chr 7:65,434,394...65,477,383

G

leucyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of LARS1 mRNA

NCBI chr18:34,452,567...34,507,030
Ensembl chr18:34,201,549...34,255,931

G

LIM and SH3 protein 1

increases expression

trovafloxacin results in increased expression of LASP1 mRNA

NCBI chr10:83,290,820...83,331,989
Ensembl chr10:82,795,137...82,943,292

G

lamin B receptor

decreases expression

trovafloxacin results in decreased expression of LBR mRNA

NCBI chr13:96,071,058...96,095,709
Ensembl chr13:93,538,920...93,564,017

G

lecithin cholesterol acyltransferase

increases expression

trovafloxacin results in increased expression of LCAT mRNA

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231

G

lactate dehydrogenase A-like 6B

increases expression

trovafloxacin results in increased expression of LDHAL6B mRNA

NCBI chr 1:48,402,997...48,404,420
Ensembl chr 1:45,991,991...45,999,272

G

low density lipoprotein receptor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580

G

low density lipoprotein receptor class A domain containing 3

decreases expression

trovafloxacin results in decreased expression of LDLRAD3 mRNA

NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:88,239,622...88,481,267

G

low density lipoprotein receptor adaptor protein 1

increases expression

trovafloxacin results in increased expression of LDLRAP1 mRNA

NCBI chr 5:152,239,296...152,262,290
Ensembl chr 5:146,955,607...146,978,601

G

leucine, glutamate and lysine rich 1

increases expression

trovafloxacin results in increased expression of LEKR1 mRNA

NCBI chr 2:152,195,003...152,376,389
Ensembl chr 2:149,891,106...150,060,469

G

lens epithelial protein

increases expression

trovafloxacin results in increased expression of LENEP mRNA

NCBI chr 2:177,117,171...177,117,859
Ensembl chr 2:174,819,459...174,820,127

G

leucine zipper and EF-hand containing transmembrane protein 1

decreases expression

trovafloxacin results in decreased expression of LETM1 mRNA

NCBI chr14:81,167,268...81,206,776
Ensembl chr14:76,942,729...76,984,904

G

galectin 9

increases expression

trovafloxacin results in increased expression of LGALS9 mRNA

NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045

G

galectin-like

decreases expression

trovafloxacin results in decreased expression of LGALSL mRNA

NCBI chr14:99,198,340...99,205,846
Ensembl chr14:94,996,990...95,004,980

G

leucine-rich repeat-containing G protein-coupled receptor 4

increases expression

trovafloxacin results in increased expression of LGR4 mRNA

NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:96,447,858...96,548,899

G

LIM homeobox 2

decreases expression

trovafloxacin results in decreased expression of LHX2 mRNA

NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:22,126,007...22,143,908

G

LIF, interleukin 6 family cytokine

increases expression

trovafloxacin results in increased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

DNA ligase 1

decreases expression

trovafloxacin results in decreased expression of LIG1 mRNA

NCBI chr 1:83,243,043...83,281,707
Ensembl chr 1:74,165,842...74,204,413

G

leukocyte immunoglobulin like receptor B4

increases expression

trovafloxacin results in increased expression of LILRB4B mRNA

NCBI chr 1:78,847,685...78,853,294
Ensembl chr 1:69,805,250...69,810,660

G

lin-54 DREAM MuvB core complex component

decreases expression

trovafloxacin results in decreased expression of LIN54 mRNA

NCBI chr14:9,434,093...9,514,091
Ensembl chr14:9,130,336...9,187,790

G

lipase, family member N

decreases expression

trovafloxacin results in decreased expression of LIPN mRNA

NCBI chr 1:240,998,154...241,016,658
Ensembl chr 1:231,584,956...231,603,468

G

lipopolysaccharide-induced TNF factor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of LITAF mRNA

NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763

G

limb and CNS expressed 1

decreases expression

trovafloxacin results in decreased expression of LIX1 mRNA

NCBI chr 1:66,802,044...66,859,040
Ensembl chr 1:58,128,961...58,185,964

G

LLGL scribble cell polarity complex component 2

increases expression

trovafloxacin results in increased expression of LLGL2 mRNA

NCBI chr10:101,549,911...101,585,466
Ensembl chr10:101,051,408...101,086,525

G

lamin A/C

decreases expression
increases expression

trovafloxacin results in decreased expression of LMNA mRNA
trovafloxacin results in increased expression of LMNA mRNA

PMID:24136188 PMID:35537566

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

decreases expression

trovafloxacin results in decreased expression of LMNB1 mRNA

NCBI chr18:52,373,939...52,413,284
Ensembl chr18:50,175,874...50,214,502

G

LIM domain only 4

decreases expression

trovafloxacin results in decreased expression of LMO4 mRNA

NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:233,264,182...233,280,880

G

small nucleolar RNA SNORA43

increases expression

trovafloxacin results in increased expression of SNORA43 mRNA

NCBI chr 8:110,101,179...110,101,316
Ensembl chr 8:110,101,179...110,101,316

G

lon peptidase 1, mitochondrial

decreases expression

trovafloxacin results in decreased expression of LONP1 mRNA

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,447,447...1,459,771

G

lipin 1

increases expression

trovafloxacin results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:39,312,748...39,417,097

G

lipin 3

increases expression

trovafloxacin results in increased expression of LPIN3 mRNA

NCBI chr 3:169,953,479...169,978,034
Ensembl chr 3:149,534,051...149,558,327

G

LDL receptor related protein 6

increases expression

trovafloxacin results in increased expression of LRP6 mRNA

NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497

G

LDL receptor related protein 8

decreases expression

trovafloxacin results in decreased expression of LRP8 mRNA

NCBI chr 5:127,792,236...127,864,207
Ensembl chr 5:122,563,453...122,631,352

G

leucine rich repeat containing 41

increases expression

trovafloxacin results in increased expression of LRRC41 mRNA

NCBI chr 5:134,791,256...134,812,177
Ensembl chr 5:129,554,547...129,575,449

G

leucine rich repeat containing 63

decreases expression

trovafloxacin results in decreased expression of LRRC63 mRNA

NCBI chr15:50,400,199...50,437,321
Ensembl chr15:50,400,200...50,437,321

G

leucine rich repeat containing 75A

decreases expression

trovafloxacin results in decreased expression of LRRC75A mRNA

NCBI chr10:47,798,028...47,842,577
Ensembl chr10:47,297,288...47,343,664

G

leucine rich repeat containing 8 VRAC subunit C

decreases expression

trovafloxacin results in decreased expression of LRRC8C mRNA

NCBI chr14:4,528,721...4,621,259
Ensembl chr14:4,227,832...4,315,249

G

leucine rich repeat and coiled-coil centrosomal protein 1

decreases expression

trovafloxacin results in decreased expression of LRRCC1 mRNA

NCBI chr 2:88,746,904...88,781,532
Ensembl chr 2:87,025,598...87,060,294

G

leucine-rich repeat kinase 2

decreases expression

trovafloxacin results in decreased expression of LRRK2 mRNA

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703

G

LRRN4 C-terminal like

decreases expression

trovafloxacin results in decreased expression of LRRN4CL mRNA

NCBI chr 1:205,743,580...205,759,879

G

leucine-rich repeats and WD repeat domain containing 1

decreases expression

trovafloxacin results in decreased expression of LRWD1 mRNA

NCBI chr12:26,166,648...26,179,689
Ensembl chr12:20,530,012...20,549,536

G

LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

trovafloxacin results in decreased expression of LSM4 mRNA

NCBI chr16:18,789,466...18,795,164
Ensembl chr16:18,755,484...18,760,926

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

trovafloxacin results in increased expression of LSM6 mRNA

NCBI chr19:46,002,592...46,017,152
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484

G

leukotriene A4 hydrolase

decreases expression

trovafloxacin results in decreased expression of LTA4H mRNA

NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:27,969,789...28,001,600

G

latent transforming growth factor beta binding protein 2

decreases expression

trovafloxacin results in decreased expression of LTBP2 mRNA

NCBI chr 6:110,161,029...110,261,586
Ensembl chr 6:104,429,947...104,526,208

G

latent transforming growth factor beta binding protein 4

decreases expression

trovafloxacin results in decreased expression of LTBP4 mRNA

NCBI chr 1:91,727,769...91,759,822
Ensembl chr 1:82,600,136...82,632,178

G

LUC7-like

increases expression

trovafloxacin results in increased expression of LUC7L mRNA

NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,273,348...15,303,112

G

LYL1, basic helix-loop-helix family member

decreases expression

trovafloxacin results in decreased expression of LYL1 mRNA

NCBI chr19:40,356,967...40,359,834
Ensembl chr19:23,452,140...23,455,007

G

lysozyme 2

decreases expression
increases expression

trovafloxacin results in decreased expression of LYZ2 mRNA
trovafloxacin results in increased expression of LYZ2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:52,906,811...52,912,106

G

microtubule-actin crosslinking factor 1

decreases expression

trovafloxacin results in decreased expression of MACF1 mRNA

NCBI chr 5:140,908,829...141,234,127
Ensembl chr 5:135,623,742...135,945,905

G

mitotic arrest deficient 2 like 1

decreases expression

trovafloxacin results in decreased expression of MAD2L1 mRNA

NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor

decreases expression

trovafloxacin results in decreased expression of MAF mRNA

NCBI chr19:60,259,200...60,622,145
Ensembl chr19:43,360,342...43,712,365

G

mal, T-cell differentiation protein 2

decreases expression

trovafloxacin results in decreased expression of MAL2 mRNA

NCBI chr 7:87,790,239...87,823,219
Ensembl chr 7:85,900,453...85,933,429

G

mannosidase, alpha, class 2A, member 1

decreases expression

trovafloxacin results in decreased expression of MAN2A1 mRNA

NCBI chr 9:111,698,913...111,855,257
Ensembl chr 9:104,252,001...104,408,349

G

mannosidase, alpha, class 2A, member 2

decreases expression

trovafloxacin results in decreased expression of MAN2A2 mRNA

NCBI chr 1:143,712,157...143,736,624
Ensembl chr 1:134,306,236...134,327,315

G

mannosidase beta like

increases expression

trovafloxacin results in increased expression of MANBAL mRNA

NCBI chr 3:166,455,067...166,484,652
Ensembl chr 3:146,035,066...146,064,676

G

mesencephalic astrocyte-derived neurotrophic factor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MANF mRNA

NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:107,548,352...107,551,438

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions
increases expression

TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3A mRNA]

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

[trovafloxacin co-treated with TNF protein] results in increased expression of MAP1LC3B mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein
trovafloxacin results in increased expression of MAP1LC3B mRNA

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen-activated protein kinase kinase 6

decreases expression

trovafloxacin results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase 7

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAP2K7 mRNA

NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MAP3K8 mRNA

NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

increases activity
increases phosphorylation
multiple interactions

trovafloxacin results in increased activity of MAPK1 protein
trovafloxacin results in increased phosphorylation of MAPK1 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK1 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK1 protein]

PMID:24525298 PMID:32035082 PMID:33609687

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases activity
increases phosphorylation
multiple interactions

trovafloxacin results in increased activity of MAPK3 protein
trovafloxacin results in increased phosphorylation of MAPK3 protein
[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein; ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [trovafloxacin results in increased activity of MAPK3 protein]

PMID:24525298 PMID:32035082 PMID:33609687

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

trovafloxacin results in increased phosphorylation of MAPK8 protein
ATG5 protein affects the reaction [trovafloxacin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 8 interacting protein 3

increases expression

trovafloxacin results in increased expression of MAPK8IP3 mRNA

NCBI chr10:14,422,936...14,463,387
Ensembl chr10:13,918,400...13,958,273

G

MAPK activated protein kinase 2

multiple interactions
increases phosphorylation

SB 203580 inhibits the reaction [trovafloxacin results in increased phosphorylation of MAPKAPK2 protein]

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457

G

MARCKS-like 1

increases expression

trovafloxacin results in increased expression of MARCKSL1 mRNA

NCBI chr 5:147,135,827...147,138,150
Ensembl chr 5:141,850,110...141,853,817

G

microtubule associated serine/threonine kinase-like

decreases expression

trovafloxacin results in decreased expression of MASTL mRNA

NCBI chr17:90,158,592...90,195,550
Ensembl chr17:85,251,997...85,287,353

G

mitochondrial antiviral signaling protein

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MAVS mRNA

NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:118,451,743...118,466,094

G

MYC associated zinc finger protein

decreases expression

trovafloxacin results in decreased expression of MAZ mRNA

NCBI chr 1:191,060,271...191,065,722
Ensembl chr 1:181,629,729...181,650,408

G

metallo-beta-lactamase domain containing 1

decreases expression

trovafloxacin results in decreased expression of MBLAC1 mRNA

NCBI chr12:22,185,142...22,186,404
Ensembl chr12:17,071,465...17,072,735

G

melanoma cell adhesion molecule

decreases expression

trovafloxacin results in decreased expression of MCAM mRNA

NCBI chr 8:53,376,225...53,384,407
Ensembl chr 8:44,479,376...44,487,571

G

MCF.2 cell line derived transforming sequence-like

decreases expression

trovafloxacin results in decreased expression of MCF2L mRNA

NCBI chr16:83,209,277...83,355,683
Ensembl chr16:76,507,133...76,652,733

G

minichromosome maintenance complex component 5

decreases expression

trovafloxacin results in decreased expression of MCM5 mRNA

NCBI chr19:13,488,813...13,510,131
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 7

decreases expression

trovafloxacin results in decreased expression of MCM7 mRNA

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:17,042,212...17,050,063

G

minichromosome maintenance 8 homologous recombination repair factor

decreases expression

trovafloxacin results in decreased expression of MCM8 mRNA

NCBI chr 3:140,539,590...140,569,891
Ensembl chr 3:120,086,763...120,117,008

G

minichromosome maintenance 9 homologous recombination repair factor

decreases expression

trovafloxacin results in decreased expression of MCM9 mRNA

NCBI chr20:33,369,325...33,472,243
Ensembl chr20:32,844,951...32,929,600

G

mediator of DNA damage checkpoint 1

decreases expression

trovafloxacin results in decreased expression of MDC1 mRNA

NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240

G

malate dehydrogenase 2

decreases expression

trovafloxacin results in decreased expression of MDH2 mRNA

NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271

G

Mdm1 nuclear protein

decreases expression

trovafloxacin results in decreased expression of MDM1 mRNA

NCBI chr 7:55,615,459...55,651,889
Ensembl chr 7:53,729,610...53,766,034

G

MDM2 proto-oncogene

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MDM2 mRNA
trovafloxacin results in increased expression of MDM2 mRNA

PMID:18930950 PMID:35537566

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 1

decreases expression

trovafloxacin results in decreased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304

G

mediator complex subunit 10

increases expression

trovafloxacin results in increased expression of MED10 mRNA

NCBI chr 1:35,298,494...35,310,163
Ensembl chr 1:33,470,066...33,475,767

G

mediator complex subunit 14

decreases expression

trovafloxacin results in decreased expression of MED14 mRNA

NCBI chr X:12,709,406...12,800,642
Ensembl chr X:10,036,805...10,126,240

G

mediator complex subunit 20

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MED20 mRNA
trovafloxacin results in increased expression of MED20 mRNA

PMID:18930950 PMID:35537566

NCBI chr 9:20,867,681...20,880,288
Ensembl chr 9:13,370,146...13,382,476

G

mediator complex subunit 22

increases expression

trovafloxacin results in increased expression of MED22 mRNA

NCBI chr 3:30,631,829...30,636,911
Ensembl chr 3:10,233,754...10,238,836

G

mediator complex subunit 29

increases expression

trovafloxacin results in increased expression of MED29 mRNA

NCBI chr 1:92,805,505...92,810,908
Ensembl chr 1:83,677,961...83,683,365

G

multiple EGF-like-domains 9

decreases expression

trovafloxacin results in decreased expression of MEGF9 mRNA

NCBI chr 5:89,008,679...89,120,731
Ensembl chr 5:83,993,565...84,105,622

G

maternal embryonic leucine zipper kinase

decreases expression

trovafloxacin results in decreased expression of MELK mRNA

NCBI chr 5:63,336,151...63,396,254
Ensembl chr 5:58,540,449...58,600,937

G

major facilitator superfamily domain containing 1

decreases expression

trovafloxacin results in decreased expression of MFSD1 mRNA

NCBI chr 2:154,156,167...154,176,209
Ensembl chr 2:151,846,146...151,867,045

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

trovafloxacin results in increased expression of MFSD2A mRNA

NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:135,225,816...135,240,690

G

major facilitator superfamily domain containing 3

decreases expression

trovafloxacin results in decreased expression of MFSD3 mRNA

NCBI chr 7:110,300,254...110,304,108
Ensembl chr 7:108,421,350...108,423,461

G

major facilitator superfamily domain containing 4B3

decreases expression

trovafloxacin results in decreased expression of MFSD4B3-PS mRNA

NCBI chr20:44,923,703...44,948,921
Ensembl chr20:43,371,903...43,394,510

G

mitochondria-localized glutamic acid-rich protein

decreases expression

trovafloxacin results in decreased expression of MGARP mRNA

NCBI chr 2:137,582,152...137,590,294
Ensembl chr 2:135,431,283...135,439,612

G

monoglyceride lipase

decreases expression

trovafloxacin results in decreased expression of MGLL mRNA

NCBI chr 4:122,749,436...122,851,440
Ensembl chr 4:121,192,195...121,294,179

G

O-6-methylguanine-DNA methyltransferase

increases expression

trovafloxacin results in increased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756

G

MICAL-like 1

increases expression

trovafloxacin results in increased expression of MICALL1 mRNA

NCBI chr 7:112,557,192...112,587,618
Ensembl chr 7:110,676,775...110,707,177

G

MICAL-like 2

increases expression

trovafloxacin results in increased expression of MICALL2 mRNA

NCBI chr12:20,013,037...20,041,795
Ensembl chr12:14,899,157...14,927,946

G

midnolin

increases expression

trovafloxacin results in increased expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:9,549,650...9,559,752

G

mitochondrial elongation factor 2

increases expression

trovafloxacin results in increased expression of MIEF2 mRNA

NCBI chr10:45,907,576...45,913,658
Ensembl chr10:45,408,082...45,414,144

G

migration and invasion inhibitory protein

decreases expression

trovafloxacin results in decreased expression of MIIP mRNA

NCBI chr 5:163,575,689...163,582,739
Ensembl chr 5:158,292,511...158,299,694

G

microRNA 877

increases expression

trovafloxacin results in increased expression of MIR877 mRNA

NCBI chr20:2,816,284...2,816,368
Ensembl chr20:2,811,476...2,811,560

G

Mirlet7b host gene

increases expression

trovafloxacin results in increased expression of LNCPPARA mRNA

G

MIS18 kinetochore protein A

decreases expression

trovafloxacin results in decreased expression of MIS18A mRNA

NCBI chr11:43,454,129...43,467,157
Ensembl chr11:29,967,701...29,981,062

G

MIS18 binding protein 1

decreases expression

trovafloxacin results in decreased expression of MIS18BP1 mRNA

NCBI chr 6:88,918,743...88,968,225
Ensembl chr 6:83,182,499...83,231,383

G

mitochondrial matrix import factor 23

increases expression

trovafloxacin results in increased expression of MIX23 mRNA

NCBI chr11:78,166,038...78,186,323
Ensembl chr11:64,660,711...64,681,000

G

marker of proliferation Ki-67

decreases expression

trovafloxacin results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 1

decreases expression

trovafloxacin results in decreased expression of MKNK1 mRNA

NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:129,318,170...129,357,639

G

makorin, ring finger protein, 2

decreases expression

trovafloxacin results in decreased expression of MKRN2 mRNA

NCBI chr 4:150,334,164...150,352,271
Ensembl chr 4:148,661,553...148,679,642

G

makorin, ring finger protein, 3

increases expression

trovafloxacin results in increased expression of MKRN3 mRNA

NCBI chr 1:125,338,664...125,341,178
Ensembl chr 1:115,926,776...115,929,283

G

myeloid leukemia factor 1

decreases expression

trovafloxacin results in decreased expression of MLF1 mRNA

NCBI chr 2:153,958,060...153,991,705
Ensembl chr 2:151,648,511...151,681,652

G

MLX interacting protein-like

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MLXIPL mRNA

NCBI chr12:27,178,158...27,213,675
Ensembl chr12:21,543,576...21,577,112

G

matrix metallopeptidase 13

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP13 mRNA

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239

G

meiotic nuclear divisions 1

decreases expression

trovafloxacin results in decreased expression of MND1 mRNA

NCBI chr 2:171,731,523...171,794,124
Ensembl chr 2:169,433,540...169,496,096

G

myeloid cell nuclear differentiation antigen

increases expression

trovafloxacin results in increased expression of MNDA mRNA; trovafloxacin results in increased expression of PYHIN1 mRNA

NCBI chr13:88,550,224...88,567,892
Ensembl chr13:86,017,892...86,034,201

G

MOB kinase activator 3B

decreases expression

trovafloxacin results in decreased expression of MOB3B mRNA

NCBI chr 5:54,342,509...54,534,164
Ensembl chr 5:49,545,815...49,737,934

G

mannosyl-oligosaccharide glucosidase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MOGS mRNA

NCBI chr 4:117,179,335...117,182,738
Ensembl chr 4:115,621,623...115,625,032

G

MOK protein kinase

increases expression

trovafloxacin results in increased expression of MOK mRNA

NCBI chr 6:135,645,018...135,675,894
Ensembl chr 6:129,823,795...129,854,700

G

macrophage expressed 1

increases expression

trovafloxacin results in increased expression of MPEG1 mRNA

NCBI chr 1:218,876,848...218,881,364
Ensembl chr 1:209,452,133...209,458,855

G

N-methylpurine-DNA glycosylase

decreases expression

trovafloxacin results in decreased expression of MPG mRNA

NCBI chr10:15,900,697...15,906,981
Ensembl chr10:15,395,782...15,402,520

G

M-phase phosphoprotein 8

increases expression

trovafloxacin results in increased expression of MPHOSPH8 mRNA

NCBI chr15:34,916,169...34,944,038
Ensembl chr15:30,686,613...30,828,810

G

major histocompatibility complex, class I-related

decreases expression

trovafloxacin results in decreased expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970

G

mannose receptor, C type 1

decreases expression

trovafloxacin results in decreased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857

G

MRN complex interacting protein

decreases expression

trovafloxacin results in decreased expression of MRNIP mRNA

NCBI chr10:35,002,440...35,026,555
Ensembl chr10:34,501,384...34,525,469

G

maestro heat-like repeat family member 1

decreases expression

trovafloxacin results in decreased expression of MROH1 mRNA

NCBI chr 7:109,979,344...110,052,800
Ensembl chr 7:108,102,734...108,172,146

G

mitochondrial ribosomal protein L12

decreases expression

trovafloxacin results in decreased expression of MRPL12 mRNA

NCBI chr10:106,256,746...106,261,249
Ensembl chr10:105,758,410...105,762,913

G

mitochondrial ribosomal protein L38

decreases expression

trovafloxacin results in decreased expression of MRPL38 mRNA

NCBI chr10:101,864,242...101,871,048
Ensembl chr10:101,365,353...101,372,171

G

mitochondrial ribosomal protein S18B

decreases expression
increases expression

trovafloxacin results in decreased expression of MRPS18B mRNA
trovafloxacin results in increased expression of MRPS18B mRNA

PMID:24136188 PMID:35537566

NCBI chr20:2,842,978...2,849,065
Ensembl chr20:2,838,030...2,844,260

G

mutS homolog 3

decreases expression

trovafloxacin results in decreased expression of MSH3 mRNA

NCBI chr 2:25,179,400...25,320,857

G

mutS homolog 5

decreases expression

trovafloxacin results in decreased expression of MSH5 mRNA

NCBI chr20:3,779,180...3,797,996
Ensembl chr20:3,776,942...3,793,336

G

metallothionein 1

increases expression

trovafloxacin results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2

decreases expression
multiple interactions

trovafloxacin results in decreased expression of MT2 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MT1E mRNA

PMID:18930950 PMID:35537566

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

MDM2 binding protein

decreases expression

trovafloxacin results in decreased expression of MTBP mRNA

NCBI chr 7:88,862,939...88,945,491
Ensembl chr 7:86,973,069...87,050,827

G

mitochondrial carrier 1

decreases expression

trovafloxacin results in decreased expression of MTCH1 mRNA

NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,389,949...7,413,426

G

mitochondrial fission regulator 2

decreases expression

trovafloxacin results in decreased expression of MTFR2 mRNA

NCBI chr 1:16,942,814...16,958,218
Ensembl chr 1:15,070,894...15,148,832

G

mitochondrial ribosome-associated GTPase 1

decreases expression

trovafloxacin results in decreased expression of MTG1 mRNA

NCBI chr 1:204,361,176...204,373,917
Ensembl chr 1:194,931,531...194,944,277

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

decreases expression

trovafloxacin results in decreased expression of MTHFD1L mRNA

NCBI chr 1:42,849,424...43,038,313
Ensembl chr 1:40,444,008...40,632,905

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

decreases expression

trovafloxacin results in decreased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:115,811,139...115,822,608

G

microsomal triglyceride transfer protein

decreases expression

trovafloxacin results in decreased expression of MTTP mRNA

PMID:24136188 PMID:35537566

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:226,613,090...226,654,239

G

microtubule associated scaffold protein 2

increases expression

trovafloxacin results in increased expression of MTUS2 mRNA

NCBI chr12:6,706,531...7,078,331
Ensembl chr12:6,706,532...7,078,331

G

mitochondrial E3 ubiquitin protein ligase 1

increases expression

trovafloxacin results in increased expression of MUL1 mRNA

NCBI chr 5:155,936,112...155,945,163
Ensembl chr 5:150,652,812...150,661,863

G

MUS81 structure-specific endonuclease subunit

decreases expression

trovafloxacin results in decreased expression of MUS81 mRNA

NCBI chr 1:212,219,793...212,225,214
Ensembl chr 1:202,790,466...202,795,843

G

musculoskeletal, embryonic nuclear protein 1

increases expression

trovafloxacin results in increased expression of MUSTN1 mRNA

NCBI chr16:6,079,355...6,081,608
Ensembl chr16:6,072,833...6,075,161

G

mutY DNA glycosylase

decreases expression

trovafloxacin results in decreased expression of MUTYH mRNA

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:130,274,122...130,286,146

G

MX dynamin like GTPase 1

increases expression

trovafloxacin results in increased expression of MX2 mRNA

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507

G

Max dimerization protein 3

decreases expression

trovafloxacin results in decreased expression of MXD3 mRNA

NCBI chr17:9,306,552...9,310,278
Ensembl chr17:9,301,399...9,305,157

G

myeloid-associated differentiation marker-like 2

decreases expression

trovafloxacin results in decreased expression of MYADML2 mRNA

NCBI chr10:106,420,856...106,425,899
Ensembl chr10:105,925,947...105,927,575

G

MYB proto-oncogene like 2

decreases expression

trovafloxacin results in decreased expression of MYBL2 mRNA

NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708

G

myosin binding protein C3

increases expression

trovafloxacin results in increased expression of MYBPC3 mRNA

NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:77,095,252...77,113,405

G

MYC proto-oncogene, bHLH transcription factor

increases expression

trovafloxacin results in increased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

Myc binding protein

increases expression

trovafloxacin results in increased expression of MYCBP mRNA

NCBI chr 5:141,420,727...141,427,938
Ensembl chr 5:136,135,931...136,145,616

G

MYC binding protein 2

decreases expression

trovafloxacin results in decreased expression of MYCBP2 mRNA

NCBI chr15:86,352,061...86,590,126
Ensembl chr15:79,937,354...80,175,498

G

MYCL proto-oncogene, bHLH transcription factor

increases expression

trovafloxacin results in increased expression of MYCL mRNA

NCBI chr 5:140,559,843...140,566,704
Ensembl chr 5:135,274,748...135,281,582

G

MYD88, innate immune signal transduction adaptor

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

myosin heavy chain 10

increases expression

trovafloxacin results in increased expression of MYH10 mRNA

NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,394,389...53,525,165

G

myosin heavy chain 14

decreases expression

trovafloxacin results in decreased expression of MYH14 mRNA

NCBI chr 1:104,232,778...104,295,369
Ensembl chr 1:95,096,266...95,158,836

G

myosin heavy chain 7B

decreases expression

trovafloxacin results in decreased expression of MYH7B mRNA

NCBI chr 3:164,537,211...164,582,441
Ensembl chr 3:144,098,190...144,122,084

G

myosin light chain 11

decreases expression

trovafloxacin results in decreased expression of MYLPF mRNA

NCBI chr 1:191,257,432...191,263,046
Ensembl chr 1:181,829,743...181,832,545

G

myosin IXA

decreases expression

trovafloxacin results in decreased expression of MYO9A mRNA

NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:60,149,234...60,350,514

G

myomesin 1

decreases expression

trovafloxacin results in decreased expression of MYOM1 mRNA

NCBI chr 9:118,362,547...118,485,954
Ensembl chr 9:110,915,943...111,039,344

G

myozenin 1

decreases expression

trovafloxacin results in decreased expression of MYOZ1 mRNA

NCBI chr15:3,693,576...3,700,831
Ensembl chr15:3,644,368...3,652,884

G

myeloid zinc finger 1

decreases expression

trovafloxacin results in decreased expression of MZF1 mRNA

NCBI chr 1:82,742,709...82,755,069
Ensembl chr 1:73,670,541...73,681,635

G

NEDD4 binding protein 2-like 1

decreases expression

trovafloxacin results in decreased expression of N4BP2L1 mRNA

NCBI chr12:4,938,199...4,965,003
Ensembl chr12:102,573...127,257

G

Nedd4 binding protein 3

decreases expression

trovafloxacin results in decreased expression of N4BP3 mRNA

NCBI chr10:36,400,053...36,407,609
Ensembl chr10:35,899,096...35,907,001

G

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

decreases expression

trovafloxacin results in decreased expression of NAA15 mRNA

NCBI chr 2:137,608,883...137,671,618
Ensembl chr 2:135,457,948...135,520,756

G

N-acetyl-alpha-glucosaminidase

decreases expression

trovafloxacin results in decreased expression of NAGLU mRNA

NCBI chr10:86,501,864...86,509,333
Ensembl chr10:86,001,566...86,008,972

G

NSF attachment protein beta

increases expression

trovafloxacin results in increased expression of NAPB mRNA

NCBI chr 3:156,585,394...156,632,418
Ensembl chr 3:136,133,428...136,179,345

G

nicotinate phosphoribosyltransferase

increases expression

trovafloxacin results in increased expression of NAPRT mRNA

NCBI chr 7:109,457,328...109,460,817
Ensembl chr 7:107,576,627...107,580,102

G

asparaginyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of NARS1 mRNA

NCBI chr18:60,259,506...60,275,782
Ensembl chr18:57,989,308...58,005,622

G

nuclear autoantigenic sperm protein

decreases expression

trovafloxacin results in decreased expression of NASP mRNA

NCBI chr 5:135,294,599...135,319,992
Ensembl chr 5:130,057,363...130,082,928

G

NAD(P)HX dehydratase

decreases expression

trovafloxacin results in decreased expression of NAXD mRNA

NCBI chr16:84,689,776...84,706,256
Ensembl chr16:77,987,726...78,004,192

G

NBAS subunit of NRZ tethering complex

decreases expression

trovafloxacin results in decreased expression of NBAS mRNA

NCBI chr 6:41,777,253...42,081,895
Ensembl chr 6:36,048,191...36,352,984

G

non-SMC condensin I complex, subunit D2

decreases expression

trovafloxacin results in decreased expression of NCAPD2 mRNA

NCBI chr 4:159,655,051...159,677,938
Ensembl chr 4:157,968,815...157,992,020

G

non-SMC condensin II complex, subunit D3

decreases expression

trovafloxacin results in decreased expression of NCAPD3 mRNA

NCBI chr 8:33,696,214...33,765,520
Ensembl chr 8:25,437,123...25,506,373

G

non-SMC condensin I complex, subunit G

decreases expression

trovafloxacin results in decreased expression of NCAPG mRNA

NCBI chr14:69,616,473...69,645,445
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin II complex, subunit G2

decreases expression

trovafloxacin results in decreased expression of NCAPG2 mRNA

NCBI chr 6:143,484,651...143,561,850
Ensembl chr 6:137,342,943...137,415,159

G

non-SMC condensin I complex, subunit H

decreases expression

trovafloxacin results in decreased expression of NCAPH mRNA

NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:114,371,941...114,399,180

G

non-SMC condensin II complex, subunit H2

decreases expression

trovafloxacin results in decreased expression of NCAPH2 mRNA

NCBI chr 7:122,302,550...122,319,570
Ensembl chr 7:120,422,956...120,439,938

G

nuclear cap binding subunit 3

decreases expression

trovafloxacin results in decreased expression of NCBP3 mRNA

NCBI chr10:58,164,241...58,193,952
Ensembl chr10:57,665,716...57,695,432

G

NDC80 kinetochore complex component

decreases expression

trovafloxacin results in decreased expression of NDC80 mRNA

NCBI chr 9:118,853,806...118,887,582
Ensembl chr 9:111,407,191...111,440,924

G

nudE neurodevelopment protein 1

decreases expression

trovafloxacin results in decreased expression of NDE1 mRNA

NCBI chr10:1,347,010...1,391,167
Ensembl chr10:839,788...883,869

G

N-myc downstream regulated 1

decreases expression

trovafloxacin results in decreased expression of NDRG1 mRNA

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase complex assembly factor 4

decreases expression

trovafloxacin results in decreased expression of NDUFAF4 mRNA

NCBI chr 5:43,401,795...43,406,967
Ensembl chr 5:38,605,153...38,610,336

G

NADH:ubiquinone oxidoreductase core subunit V1

decreases expression

trovafloxacin results in decreased expression of NDUFV1 mRNA

NCBI chr 1:210,729,856...210,735,103
Ensembl chr 1:201,299,985...201,305,466

G

nuclear paraspeckle assembly transcript 1

increases expression

trovafloxacin results in increased expression of NEAT1 mRNA

NCBI chr 1:212,507,512...212,568,055

G

nebulin

increases expression

trovafloxacin results in increased expression of NEB mRNA

NCBI chr 3:57,022,822...57,220,752
Ensembl chr 3:36,613,716...36,811,574

G

NECAP endocytosis associated 1

increases expression

trovafloxacin results in increased expression of NECAP1 mRNA

NCBI chr 4:157,775,890...157,790,992
Ensembl chr 4:156,103,988...156,119,068

G

NEDD4 like E3 ubiquitin protein ligase

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD4L mRNA
trovafloxacin results in decreased expression of NEDD4L mRNA

PMID:18930950 PMID:35537566

NCBI chr18:60,663,918...60,996,824
Ensembl chr18:58,393,509...58,723,137

G

neural precursor cell expressed, developmentally down-regulated 9

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NEDD9 mRNA
trovafloxacin results in decreased expression of NEDD9 mRNA

PMID:18930950 PMID:35537566

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,282,326...23,468,019

G

nei-like DNA glycosylase 3

decreases expression

trovafloxacin results in decreased expression of NEIL3 mRNA

NCBI chr16:45,091,401...45,151,419
Ensembl chr16:38,359,371...38,418,527

G

NIMA-related kinase 1

decreases expression

trovafloxacin results in decreased expression of NEK1 mRNA

NCBI chr16:34,009,092...34,137,418
Ensembl chr16:28,998,231...29,117,723

G

NIMA-related kinase 8

decreases expression

trovafloxacin results in decreased expression of NEK8 mRNA

NCBI chr10:63,558,940...63,570,954
Ensembl chr10:63,061,253...63,072,416

G

nuclear envelope integral membrane protein 1

decreases expression

trovafloxacin results in decreased expression of NEMP1 mRNA

NCBI chr 7:65,399,297...65,424,054
Ensembl chr 7:63,479,951...63,534,602

G

neogenin 1

decreases expression

trovafloxacin results in decreased expression of NEO1 mRNA

NCBI chr 8:68,169,711...68,322,158
Ensembl chr 8:59,275,569...59,430,348

G

nestin

decreases expression

trovafloxacin results in decreased expression of NES mRNA

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777

G

neuralized E3 ubiquitin protein ligase 1B

decreases expression

trovafloxacin results in decreased expression of NEURL1B mRNA

NCBI chr10:17,258,317...17,289,362
Ensembl chr10:16,757,208...16,785,119

G

nexilin (F actin binding protein)

decreases expression

trovafloxacin results in decreased expression of NEXN mRNA

NCBI chr 2:243,846,736...243,878,268
Ensembl chr 2:241,186,790...241,218,342

G

nuclear factor of activated T-cells 1

increases expression

trovafloxacin results in increased expression of NFATC1 mRNA

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor I/A

decreases expression

trovafloxacin results in decreased expression of NFIA mRNA

NCBI chr 5:117,359,006...117,897,391
Ensembl chr 5:112,436,644...112,775,885

G

nuclear factor, interleukin 3 regulated

decreases expression

trovafloxacin results in decreased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858

G

NFKB inhibitor alpha

multiple interactions
increases expression

[Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of NFKBIA protein; trovafloxacin promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]
[trovafloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
trovafloxacin results in increased expression of NFKBIA mRNA; trovafloxacin results in increased expression of NFKBIA protein

PMID:18930950 PMID:32035082 PMID:35537566

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor delta

increases expression

trovafloxacin results in increased expression of NFKBID mRNA

NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor zeta

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NFKBIZ mRNA
trovafloxacin results in increased expression of NFKBIZ mRNA

PMID:18930950 PMID:35537566

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723

G

nerve growth factor receptor

increases expression

trovafloxacin results in increased expression of TNFRSF10B mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518

G

NHERF family PDZ scaffold protein 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NHERF1 mRNA

NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,403,069...100,420,598

G

NHS-like 2

decreases expression

trovafloxacin results in decreased expression of NHSL2 mRNA

NCBI chr X:71,009,940...71,249,427
Ensembl chr X:66,970,151...67,200,911

G

niban apoptosis regulator 2

increases expression

trovafloxacin results in increased expression of FAM129B mRNA

NCBI chr 3:36,572,356...36,621,968
Ensembl chr 3:16,174,659...16,224,293

G

nidogen 2

decreases expression

trovafloxacin results in decreased expression of NID2 mRNA

NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,458,084...4,513,843

G

Sodium/potassium transporting ATPase interacting 1

increases expression

trovafloxacin results in increased expression of NKAIN1 mRNA

NCBI chr 5:148,031,685...148,076,834
Ensembl chr 5:142,747,505...142,791,863

G

NLR family member X1

decreases expression

trovafloxacin results in decreased expression of NLRX1 mRNA

NCBI chr 8:53,486,866...53,503,498
Ensembl chr 8:44,590,048...44,606,484

G

NME/NM23 nucleoside diphosphate kinase 1

decreases expression

trovafloxacin results in decreased expression of NME1 mRNA

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408

G

NME/NM23 nucleoside diphosphate kinase 2

decreases expression

trovafloxacin results in decreased expression of NME2 mRNA

NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

G

NmrA like redox sensor 1

decreases expression

trovafloxacin results in decreased expression of NMRAL1 mRNA

NCBI chr10:11,348,080...11,356,621
Ensembl chr10:10,841,799...10,850,192

G

neuronatin

increases expression

trovafloxacin results in increased expression of NNAT mRNA

NCBI chr 3:166,646,373...166,648,845
Ensembl chr 3:146,226,407...146,228,834

G

nicotinamide nucleotide transhydrogenase

decreases expression

trovafloxacin results in decreased expression of NNT mRNA

NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:51,411,413...51,504,823

G

nocturnin

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:135,271,189...135,291,400

G

nitric oxide synthase 1

decreases expression

trovafloxacin results in decreased expression of NOS1 mRNA

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

decreases expression

trovafloxacin results in decreased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 2

decreases expression

trovafloxacin results in decreased expression of NOTCH2 mRNA

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088

G

NADP-dependent oxidoreductase domain containing 1

decreases expression

trovafloxacin results in decreased expression of NOXRED1 mRNA

NCBI chr 6:112,593,296...112,619,113
Ensembl chr 6:106,862,343...106,884,712

G

nephrocystin 4

decreases expression

trovafloxacin results in decreased expression of NPHP4 mRNA

NCBI chr 5:168,270,522...168,356,393
Ensembl chr 5:162,988,370...163,073,706

G

nephronectin

decreases expression

trovafloxacin results in decreased expression of NPNT mRNA

NCBI chr 2:224,065,191...224,133,567
Ensembl chr 2:221,391,153...221,459,401

G

nuclear receptor subfamily 1, group D, member 1

increases expression

trovafloxacin results in increased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 2, group F, member 6

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NR2F6 mRNA

NCBI chr16:18,080,003...18,087,449
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

increases expression

trovafloxacin results in increased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression

trovafloxacin results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

increases expression

trovafloxacin results in increased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877

G

neurotrophin receptor associated death domain

increases expression

trovafloxacin results in increased expression of NRADD mRNA

NCBI chr 8:119,478,055...119,481,336
Ensembl chr 8:110,599,667...110,603,149

G

NSL1 component of MIS12 kinetochore complex

decreases expression

trovafloxacin results in decreased expression of NSL1 mRNA

NCBI chr13:105,176,163...105,205,179
Ensembl chr13:102,649,058...102,674,054

G

5'-nucleotidase domain containing 2

decreases expression

trovafloxacin results in decreased expression of NT5DC2 mRNA

NCBI chr16:6,328,925...6,336,978
Ensembl chr16:6,322,236...6,330,537

G

NUAK family kinase 2

increases expression

trovafloxacin results in increased expression of NUAK2 mRNA

NCBI chr13:46,305,744...46,322,755
Ensembl chr13:43,753,832...43,770,604

G

nudix hydrolase 22

increases expression

trovafloxacin results in increased expression of NUDT22 mRNA

NCBI chr 1:213,612,008...213,615,626
Ensembl chr 1:204,182,802...204,186,280

G

nudix hydrolase 6

decreases expression

trovafloxacin results in decreased expression of NUDT6 mRNA

NCBI chr 2:122,218,031...122,234,488
Ensembl chr 2:120,290,847...120,306,230

G

nudix hydrolase 7

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of NUDT7 mRNA

NCBI chr19:59,034,808...59,049,148
Ensembl chr19:42,125,711...42,151,081

G

NUF2 component of NDC80 kinetochore complex

decreases expression

trovafloxacin results in decreased expression of NUF2 mRNA

NCBI chr13:84,226,448...84,290,957
Ensembl chr13:81,693,598...81,722,766

G

nucleoporin 205

decreases expression

trovafloxacin results in decreased expression of NUP205 mRNA

NCBI chr 4:64,822,051...64,887,996
Ensembl chr 4:63,854,783...63,920,844

G

nucleoporin 210

decreases expression

trovafloxacin results in decreased expression of NUP210 mRNA

NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:123,511,559...123,609,874

G

nucleoporin 98 and 96 precursor

increases expression

trovafloxacin results in increased expression of NUP98 mRNA

NCBI chr 1:165,906,405...166,003,366
Ensembl chr 1:156,494,423...156,591,415

G

nuclear protein 1, transcriptional regulator

decreases expression

trovafloxacin results in decreased expression of NUPR1 mRNA

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281

G

nucleolar and spindle associated protein 1

decreases expression

trovafloxacin results in decreased expression of NUSAP1 mRNA

NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624

G

nucleoredoxin

decreases expression

trovafloxacin results in decreased expression of NXN mRNA

NCBI chr10:61,607,557...61,745,807
Ensembl chr10:61,110,020...61,248,251

G

nucleoredoxin-like 1

increases expression

trovafloxacin results in increased expression of NXNL1 mRNA

NCBI chr16:18,303,454...18,311,510
Ensembl chr16:18,262,688...18,279,987

G

neurexophilin 4

decreases expression

trovafloxacin results in decreased expression of NXPH4 mRNA

NCBI chr 7:65,253,043...65,261,864
Ensembl chr 7:63,367,761...63,376,579

G

2'-5' oligoadenylate synthetase 2

increases expression

trovafloxacin results in increased expression of OAS2 mRNA

NCBI chr12:41,464,568...41,492,036
Ensembl chr12:35,806,759...35,829,371

G

2'-5'-oligoadenylate synthetase-like

increases expression

trovafloxacin results in increased expression of OASL1 mRNA

NCBI chr12:47,343,551...47,356,509
Ensembl chr12:41,682,900...41,695,641

G

alpha-2u globulin PGCL4

increases expression

trovafloxacin results in increased expression of OBP3 mRNA

NCBI chr 5:79,637,234...79,640,810
Ensembl chr 5:74,842,316...74,845,757

G

opioid growth factor receptor-like 1

decreases expression

trovafloxacin results in decreased expression of OGFRL1 mRNA

NCBI chr 9:33,320,501...33,338,742
Ensembl chr 9:25,828,869...25,842,352

G

Opa interacting protein 5

decreases expression

trovafloxacin results in decreased expression of OIP5 mRNA

NCBI chr 3:127,047,559...127,057,043
Ensembl chr 3:106,593,760...106,603,250

G

olfactory receptor 1271

decreases expression

trovafloxacin results in decreased expression of OR8D1B mRNA

NCBI chr 8:48,024,543...48,029,052
Ensembl chr 8:39,127,352...39,131,900

G

5-oxoprolinase (ATP-hydrolysing)

decreases expression

trovafloxacin results in decreased expression of OPLAH mRNA

NCBI chr 7:109,892,136...109,932,403
Ensembl chr 7:108,011,475...108,035,297

G

optineurin

decreases expression

trovafloxacin results in decreased expression of OPTN mRNA

NCBI chr17:78,118,847...78,169,543
Ensembl chr17:73,209,575...73,260,251

G

ORAI calcium release-activated calcium modulator 2

increases expression

trovafloxacin results in increased expression of ORAI2 mRNA

NCBI chr12:26,136,922...26,157,041
Ensembl chr12:20,497,317...20,520,428

G

oxysterol binding protein-like 10

decreases expression

trovafloxacin results in decreased expression of OSBPL10 mRNA

NCBI chr 8:123,536,818...123,796,822
Ensembl chr 8:114,660,743...114,918,625

G

oxysterol binding protein-like 1A

decreases expression

trovafloxacin results in decreased expression of OSBPL1A mRNA

NCBI chr18:4,178,734...4,383,511
Ensembl chr18:3,904,006...4,094,585

G

O-sialoglycoprotein endopeptidase

decreases expression

trovafloxacin results in decreased expression of OSGEP mRNA

NCBI chr15:26,610,694...26,618,113
Ensembl chr15:24,137,153...24,144,568

G

oligosaccharyltransferase complex subunit 4, non-catalytic

increases expression

trovafloxacin results in increased expression of OST4 mRNA

NCBI chr 6:31,191,198...31,192,422

G

purinergic receptor P2Y2

decreases expression

trovafloxacin results in decreased expression of P2RY2 mRNA

NCBI chr 1:164,764,119...164,779,578
Ensembl chr 1:155,351,165...155,367,632

G

prolyl 3-hydroxylase 3

decreases expression

trovafloxacin results in decreased expression of P3H3 mRNA

NCBI chr 4:159,332,514...159,348,428
Ensembl chr 4:157,646,243...157,662,035

G

PABIR family member 2

decreases expression

trovafloxacin results in decreased expression of PABIR2 mRNA

NCBI chr X:137,908,653...137,935,153
Ensembl chr X:132,989,124...133,015,580

G

poly(A) binding protein, cytoplasmic 1-like

increases expression

trovafloxacin results in increased expression of PABPC1L mRNA

NCBI chr 3:173,111,856...173,145,389
Ensembl chr 3:152,693,700...152,725,997

G

protein kinase C and casein kinase substrate in neurons 2

decreases expression

trovafloxacin results in decreased expression of PACSIN2 mRNA

NCBI chr 7:116,385,571...116,478,609
Ensembl chr 7:114,505,152...114,598,546

G

phosphoprotein membrane anchor with glycosphingolipid microdomains 1

decreases expression

trovafloxacin results in decreased expression of PAG1 mRNA

NCBI chr 2:93,842,747...93,984,314
Ensembl chr 2:92,057,216...92,069,849

G

phosphatase domain containing, paladin 1

decreases expression

trovafloxacin results in decreased expression of PALD1 mRNA

NCBI chr20:29,812,650...29,877,733
Ensembl chr20:29,270,193...29,334,858

G

protein associated with LIN7 2, MAGUK p55 family member

decreases expression

trovafloxacin results in decreased expression of MPP6 mRNA

NCBI chr 4:80,504,298...80,584,951
Ensembl chr 4:79,124,806...79,254,140

G

polyamine oxidase

decreases expression

trovafloxacin results in decreased expression of PAOX mRNA

NCBI chr 1:204,349,326...204,358,140
Ensembl chr 1:194,903,273...194,928,504

G

par-6 family cell polarity regulator alpha

decreases expression

trovafloxacin results in decreased expression of PARD6A mRNA

NCBI chr19:50,499,420...50,502,301
Ensembl chr19:33,589,542...33,591,900

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

trovafloxacin results in increased cleavage of PARP1 protein
ATG5 protein affects the reaction [trovafloxacin results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

poly (ADP-ribose) polymerase family, member 10

increases expression

trovafloxacin results in increased expression of PARP10 mRNA

NCBI chr 7:109,829,721...109,839,054
Ensembl chr 7:107,949,043...107,958,304

G

poly (ADP-ribose) polymerase family, member 14

increases expression

trovafloxacin results in increased expression of PARP14 mRNA

NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916

G

PARP1 binding protein

decreases expression

trovafloxacin results in decreased expression of PARPBP mRNA

NCBI chr 7:24,398,897...24,468,330
Ensembl chr 7:22,511,427...22,573,695

G

PAS domain containing serine/threonine kinase

decreases expression

trovafloxacin results in decreased expression of PASK mRNA

NCBI chr 9:101,291,673...101,333,288
Ensembl chr 9:93,844,278...93,885,111

G

paired box 6

decreases expression

trovafloxacin results in decreased expression of PAX6 mRNA

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014

G

PDZ binding kinase

decreases expression

trovafloxacin results in decreased expression of PBK mRNA

NCBI chr15:44,198,506...44,209,572
Ensembl chr15:40,023,002...40,034,014

G

phenazine biosynthesis-like protein domain containing 1

increases expression

trovafloxacin results in increased expression of PBLD1 mRNA

NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,551,275...25,565,614

G

PBX homeobox 3

decreases expression

trovafloxacin results in decreased expression of PBX3 mRNA

NCBI chr 3:37,886,241...38,079,956
Ensembl chr 3:17,488,693...17,682,791

G

pyruvate carboxylase

decreases expression

trovafloxacin results in decreased expression of PCX mRNA

NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380

G

protocadherin beta 19

increases expression

trovafloxacin results in increased expression of PCDHB12 mRNA

NCBI chr18:29,204,838...29,207,646

G

protocadherin beta 20

increases expression

trovafloxacin results in increased expression of PCDHB14 mRNA

NCBI chr18:29,485,888...29,489,282
Ensembl chr18:29,211,883...29,215,258

G

protocadherin beta 22

increases expression

trovafloxacin results in increased expression of PCDHB22 mRNA

NCBI chr18:29,497,038...29,503,142
Ensembl chr18:29,223,149...29,225,536

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

decreases expression

trovafloxacin results in decreased expression of PCK2 mRNA

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283

G

PCNA clamp associated factor

decreases expression

trovafloxacin results in decreased expression of PCLAF mRNA

NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

pericentrin

decreases expression

trovafloxacin results in decreased expression of PCNT mRNA

NCBI chr20:12,189,767...12,278,179
Ensembl chr20:12,191,648...12,278,710

G

proprotein convertase subtilisin/kexin type 6

decreases expression

trovafloxacin results in decreased expression of PCSK6 mRNA

NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:119,429,265...119,627,596

G

phosphatidylcholine transfer protein

decreases expression

trovafloxacin results in decreased expression of PCTP mRNA

NCBI chr10:75,305,999...75,351,919
Ensembl chr10:74,808,887...74,849,867

G

prenylcysteine oxidase 1 like

decreases expression

trovafloxacin results in decreased expression of PCYOX1L mRNA

NCBI chr18:57,420,971...57,431,632
Ensembl chr18:55,150,650...55,161,327

G

phosphodiesterase 1B

increases expression

trovafloxacin results in increased expression of PDE1B mRNA

NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:134,627,322...134,654,580

G

phosphodiesterase 4B

decreases expression
multiple interactions

trovafloxacin results in decreased expression of PDE4B mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PDE4B mRNA

PMID:18930950 PMID:24136188

NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696

G

phosphodiesterase 4D

decreases expression

trovafloxacin results in decreased expression of PDE4D mRNA

NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 6B

decreases expression

trovafloxacin results in decreased expression of PDE6B mRNA

NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,323,310...1,366,450

G

pyruvate dehydrogenase complex, component X

decreases expression

trovafloxacin results in decreased expression of PDHX mRNA

NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:89,371,497...89,431,773

G

PDZ and LIM domain 1

decreases expression

trovafloxacin results in decreased expression of PDLIM1 mRNA

NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:239,042,385...239,091,076

G

pyruvate dehydrogenase phosphatase regulatory subunit

decreases expression

trovafloxacin results in decreased expression of PDPR mRNA

NCBI chr19:55,974,611...56,019,045
Ensembl chr19:39,065,157...39,109,688

G

PDS5 cohesin associated factor B

decreases expression

trovafloxacin results in decreased expression of PDS5B mRNA

NCBI chr12:5,038,114...5,181,208
Ensembl chr12:255,313...345,596

G

period circadian regulator 1

increases expression

trovafloxacin results in increased expression of PER1 mRNA

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431

G

period circadian regulator 2

increases expression

trovafloxacin results in increased expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459

G

PPARGC1 and ESRR induced regulator, muscle 1

increases expression

trovafloxacin results in increased expression of PERM1 mRNA

NCBI chr 5:172,082,249...172,087,542
Ensembl chr 5:166,800,030...166,805,323

G

p53 apoptosis effector related to PMP22

decreases expression

trovafloxacin results in decreased expression of PERP mRNA

NCBI chr 1:15,361,784...15,374,230
Ensembl chr 1:13,542,067...13,554,511

G

peroxisomal biogenesis factor 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PEX2 mRNA

NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:96,045,958...96,073,404

G

peroxisomal biogenesis factor 7

decreases expression

trovafloxacin results in decreased expression of PEX7 mRNA

NCBI chr 1:16,402,319...16,466,304
Ensembl chr 1:14,582,699...14,646,748

G

post-GPI attachment to proteins inositol deacylase 1

decreases expression

trovafloxacin results in decreased expression of PGAP1 mRNA

NCBI chr 9:63,470,023...63,538,772
Ensembl chr 9:55,975,667...56,044,464

G

protein-glucosylgalactosylhydroxylysine glucosidase

decreases expression

trovafloxacin results in decreased expression of PGGHG mRNA

NCBI chr 1:205,467,179...205,474,185
Ensembl chr 1:196,039,103...196,044,372

G

phosphoglycerate kinase 1

decreases expression

trovafloxacin results in decreased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:71,271,440...71,287,418

G

phosphoglucomutase 1

decreases expression

trovafloxacin results in decreased expression of PGM1 mRNA

NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:114,595,293...114,654,728

G

phosphoglucomutase 2-like 1

decreases expression

trovafloxacin results in decreased expression of PGM2L1 mRNA

NCBI chr 1:163,983,917...164,033,027
Ensembl chr 1:154,571,766...154,620,902

G

PH domain containing endocytic trafficking adaptor 1

increases expression

trovafloxacin results in increased expression of FAM109A mRNA

NCBI chr12:40,372,553...40,378,321
Ensembl chr12:34,711,810...34,717,081

G

PHD finger protein 10

decreases expression

trovafloxacin results in decreased expression of PHF10 mRNA

NCBI chr 1:64,625,373...64,642,110
Ensembl chr 1:55,952,253...55,969,038

G

PHD finger protein 11

increases expression

trovafloxacin results in increased expression of PHF11D mRNA

NCBI chr15:37,568,090...37,592,490
Ensembl chr15:33,390,292...33,413,009

G

PHD finger protein 19

decreases expression

trovafloxacin results in decreased expression of PHF19 mRNA

NCBI chr 3:38,572,766...38,604,950
Ensembl chr 3:18,175,282...18,196,405

G

PHD finger protein 7

decreases expression

trovafloxacin results in decreased expression of PHF7 mRNA

NCBI chr16:6,439,968...6,452,671
Ensembl chr16:6,433,537...6,446,911

G

phosphoglycerate dehydrogenase

decreases expression

trovafloxacin results in decreased expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944

G

phosphorylase kinase regulatory subunit alpha 2

decreases expression

trovafloxacin results in decreased expression of PHKA2 mRNA

NCBI chr X:37,979,629...38,102,656
Ensembl chr X:34,171,323...34,293,466

G

phosphorylase kinase regulatory subunit beta

decreases expression

trovafloxacin results in decreased expression of PHKB mRNA

NCBI chr19:37,179,937...37,383,979
Ensembl chr19:21,025,733...21,210,633

G

pleckstrin homology-like domain, family A, member 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PHLDA1 mRNA

NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:46,967,409...46,969,861

G

pleckstrin homology-like domain, family A, member 3

increases expression

trovafloxacin results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:47,193,086...47,196,335

G

peptidase inhibitor 16

decreases expression

trovafloxacin results in decreased expression of PI16 mRNA

NCBI chr20:7,377,739...7,387,003
Ensembl chr20:7,376,126...7,385,383

G

phosphatidylinositol 4-kinase alpha

decreases expression

trovafloxacin results in decreased expression of PI4KA mRNA

NCBI chr11:97,113,390...97,234,374
Ensembl chr11:83,609,069...83,724,080

G

PIF1 5'-to-3' DNA helicase

decreases expression

trovafloxacin results in decreased expression of PIF1 mRNA

NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:66,111,072...66,120,200

G

phosphatidylinositol glycan anchor biosynthesis, class N

decreases expression

trovafloxacin results in decreased expression of PIGN mRNA

NCBI chr13:22,173,670...22,321,344
Ensembl chr13:21,662,455...21,806,790

G

phosphatidylinositol glycan anchor biosynthesis, class V

decreases expression

trovafloxacin results in decreased expression of PIGV mRNA

NCBI chr 5:151,173,486...151,185,748
Ensembl chr 5:145,889,646...145,901,533

G

PIH1 domain containing 1

decreases expression

trovafloxacin results in decreased expression of PIH1D1 mRNA

NCBI chr 1:104,774,562...104,781,757
Ensembl chr 1:95,639,592...95,645,290

G

PIH1 domain containing 2

decreases expression

trovafloxacin results in decreased expression of PIH1D2 mRNA

NCBI chr 8:59,863,271...59,871,465
Ensembl chr 8:50,966,885...50,975,656

G

phosphoinositide-3-kinase adaptor protein 1

increases expression

trovafloxacin results in increased expression of PIK3AP1 mRNA

NCBI chr 1:250,040,250...250,194,364
Ensembl chr 1:240,093,065...240,204,828

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases expression

trovafloxacin results in decreased expression of PIK3CG mRNA

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

PICALM interacting mitotic regulator

decreases expression

trovafloxacin results in decreased expression of FAM64A mRNA

NCBI chr10:57,168,136...57,173,713
Ensembl chr10:56,669,675...56,674,791

G

PTEN induced kinase 1

increases expression

trovafloxacin results in increased expression of PINK1 mRNA

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635

G

phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PIP5K1A mRNA

NCBI chr 2:185,317,319...185,361,859
Ensembl chr 2:182,628,300...182,671,598

G

phosphatidylserine decarboxylase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PISD mRNA

NCBI chr14:82,166,401...82,215,479
Ensembl chr14:77,941,948...77,991,003

G

piwi-like RNA-mediated gene silencing 2

decreases expression

trovafloxacin results in decreased expression of PIWIL2 mRNA

NCBI chr15:51,841,104...51,907,729
Ensembl chr15:45,431,703...45,497,702

G

protein kinase, membrane associated tyrosine/threonine 1

decreases expression

trovafloxacin results in decreased expression of PKMYT1 mRNA

NCBI chr10:13,252,805...13,263,584
Ensembl chr10:12,748,237...12,758,995

G

plasminogen activator, urokinase

increases expression

trovafloxacin results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

phospholipase B domain containing 1

decreases expression

trovafloxacin results in decreased expression of PLBD1 mRNA

NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:169,472,983...169,529,277

G

phospholipase C, gamma 1

decreases expression

trovafloxacin results in decreased expression of PLCG1 mRNA

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330

G

phosphatidylinositol-specific phospholipase C, X domain containing 1

increases expression

trovafloxacin results in increased expression of PLCXD1 mRNA

NCBI chr12:52,238,450...52,241,884
Ensembl chr12:46,579,225...46,582,392

G

phospholipase D family, member 6

increases expression

trovafloxacin results in increased expression of PLD6 mRNA

NCBI chr10:45,078,081...45,080,732
Ensembl chr10:44,577,675...44,581,077

G

pleckstrin homology, MyTH4 and FERM domain containing H2

decreases expression

trovafloxacin results in decreased expression of PLEKHH2 mRNA

NCBI chr 6:15,783,179...15,893,479
Ensembl chr 6:10,032,660...10,140,794

G

pleckstrin homology domain containing N1

increases expression

trovafloxacin results in increased expression of PLEKHN1 mRNA

NCBI chr 5:172,087,524...172,095,566
Ensembl chr 5:166,804,837...166,813,155

G

perilipin 2

decreases expression

trovafloxacin results in decreased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319

G

perilipin 3

decreases expression

trovafloxacin results in decreased expression of PLIN3 mRNA

NCBI chr 9:1,198,336...1,210,212
Ensembl chr 9:1,102,366...1,123,147

G

polo-like kinase 1

decreases expression

trovafloxacin results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

increases expression

trovafloxacin results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947

G

polo-like kinase 3

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PLK3 mRNA
trovafloxacin results in increased expression of PLK3 mRNA

PMID:18930950 PMID:35537566

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:130,607,142...130,612,317

G

phospholipid phosphatase 3

increases expression

trovafloxacin results in increased expression of PLPP3 mRNA

NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:119,927,085...120,002,205

G

phospholipid phosphatase related 3

increases expression

trovafloxacin results in increased expression of PLPPR3 mRNA

NCBI chr 7:10,481,624...10,493,059
Ensembl chr 7:9,831,162...9,845,296

G

plexin A3

decreases expression

trovafloxacin results in decreased expression of PLXNA3 mRNA

NCBI chr X:157,266,986...157,282,896
Ensembl chr X:152,115,819...152,131,603

G

plexin D1

decreases expression

trovafloxacin results in decreased expression of PLXND1 mRNA

NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:149,002,784...149,043,244

G

prostate transmembrane protein, androgen induced 1

increases expression

trovafloxacin results in increased expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:162,012,751...162,060,454

G

PMS1 homolog 1, mismatch repair system component

decreases expression

trovafloxacin results in decreased expression of PMS1 mRNA

NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:48,253,410...48,340,237

G

purine nucleoside phosphorylase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PNP2 mRNA

NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986

G

POC1 centriolar protein A

decreases expression

trovafloxacin results in decreased expression of POC1A mRNA

NCBI chr 8:115,801,335...115,869,812
Ensembl chr 8:106,922,978...106,991,089

G

protein O-glucosyltransferase 2

decreases expression

trovafloxacin results in decreased expression of KDELC1 mRNA

NCBI chr 9:53,748,484...53,801,453
Ensembl chr 9:46,256,390...46,268,532

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

trovafloxacin results in decreased expression of POLA1 mRNA

NCBI chr X:62,028,475...62,342,455
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase delta 1, catalytic subunit

decreases expression

trovafloxacin results in decreased expression of POLD1 mRNA

NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase epsilon, catalytic subunit

decreases expression

trovafloxacin results in decreased expression of POLE mRNA

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:46,345,420...46,393,939

G

DNA polymerase theta

decreases expression

trovafloxacin results in decreased expression of POLQ mRNA

NCBI chr11:77,179,190...77,281,270
Ensembl chr11:63,673,816...63,775,878

G

RNA polymerase II subunit D

increases expression

trovafloxacin results in increased expression of POLR2D mRNA

NCBI chr18:23,692,578...23,699,709
Ensembl chr18:23,418,097...23,425,228

G

RNA polymerase II, I and III subunit K

increases expression

trovafloxacin results in increased expression of POLR2K mRNA

NCBI chr 7:69,241,233...69,244,579
Ensembl chr 7:67,356,113...67,357,668

G

RNA polymerase III subunit B

decreases expression

trovafloxacin results in decreased expression of POLR3B mRNA

NCBI chr 7:20,926,866...21,030,133
Ensembl chr 7:19,038,552...19,142,598

G

RNA polymerase III subunit G

increases expression

trovafloxacin results in increased expression of POLR3G mRNA

NCBI chr 2:13,680,893...13,721,802
Ensembl chr 2:11,945,217...11,986,125

G

RNA polymerase mitochondrial

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of POLRMT mRNA

NCBI chr 7:10,610,149...10,620,411
Ensembl chr 7:9,959,576...9,969,791

G

proopiomelanocortin

increases expression

trovafloxacin results in increased expression of POMC mRNA

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664

G

protein-O-mannosyltransferase 1

decreases expression

trovafloxacin results in decreased expression of POMT1 mRNA

NCBI chr 3:35,918,370...35,936,330
Ensembl chr 3:15,520,481...15,538,581

G

inorganic pyrophosphatase 1

decreases expression

trovafloxacin results in decreased expression of PPA1 mRNA

NCBI chr20:30,132,088...30,160,492
Ensembl chr20:29,590,707...29,619,215

G

peroxisome proliferator activated receptor alpha

decreases expression

trovafloxacin results in decreased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

PTPRF interacting protein alpha 4

decreases expression

trovafloxacin results in decreased expression of PPFIA4 mRNA

NCBI chr13:48,305,844...48,354,329
Ensembl chr13:45,753,827...45,802,261

G

peptidylprolyl isomerase D

increases expression

trovafloxacin results in increased expression of PPID mRNA

NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase E

decreases expression

trovafloxacin results in decreased expression of PPIE mRNA

NCBI chr 5:140,691,285...140,704,347
Ensembl chr 5:135,406,176...135,419,235

G

protein phosphatase, Mg2+/Mn2+ dependent, 1F

increases expression

trovafloxacin results in increased expression of PPM1F mRNA

NCBI chr11:97,568,627...97,598,613
Ensembl chr11:84,064,420...84,094,340

G

protein phosphatase, Mg2+/Mn2+ dependent, 1M

decreases expression

trovafloxacin results in decreased expression of PPM1M mRNA

NCBI chr 8:115,715,763...115,720,664
Ensembl chr 8:106,837,037...106,842,057

G

protoporphyrinogen oxidase

decreases expression

trovafloxacin results in decreased expression of PPOX mRNA

NCBI chr13:86,230,111...86,235,028
Ensembl chr13:83,664,891...83,701,805

G

protein phosphatase 1, regulatory subunit 10

increases expression

trovafloxacin results in increased expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,822,995...2,837,611

G

protein phosphatase 1, regulatory (inhibitor) subunit 11

increases expression

trovafloxacin results in increased expression of PPP1R11 mRNA

NCBI chr20:1,606,583...1,610,090
Ensembl chr20:1,601,346...1,604,846

G

protein phosphatase 1, regulatory (inhibitor) subunit 14A

decreases expression

trovafloxacin results in decreased expression of PPP1R14A mRNA

NCBI chr 1:93,708,269...93,718,218
Ensembl chr 1:84,586,627...84,590,671

G

protein phosphatase 1, regulatory (inhibitor) subunit 14B

decreases expression

trovafloxacin results in decreased expression of PPP1R14B mRNA

NCBI chr 1:213,594,416...213,596,527
Ensembl chr 1:204,163,299...204,167,319
Ensembl chr12:204,163,299...204,167,319

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 3F

decreases expression

trovafloxacin results in decreased expression of PPP1R3F mRNA

NCBI chr X:17,581,467...17,617,087
Ensembl chr X:14,929,323...14,945,193

G

protein phosphatase 2, regulatory subunit B'', alpha

decreases expression

trovafloxacin results in decreased expression of PPP2R3A mRNA

NCBI chr 8:110,582,479...110,720,516
Ensembl chr 8:101,704,778...101,841,502

G

protein phosphatase 3 catalytic subunit beta

decreases expression

trovafloxacin results in decreased expression of PPP3CB mRNA

NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,760,030...3,804,981

G

protein phosphatase 3 catalytic subunit gamma

decreases expression

trovafloxacin results in decreased expression of PPP3CC mRNA

NCBI chr15:51,699,586...51,771,763
Ensembl chr15:45,290,373...45,361,832

G

PML-RARA regulated adaptor molecule 1

decreases expression

trovafloxacin results in decreased expression of PRAM1 mRNA

NCBI chr 7:15,125,813...15,142,494
Ensembl chr 7:14,420,165...14,438,166

G

protein regulator of cytokinesis 1

decreases expression

trovafloxacin results in decreased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:134,250,081...134,271,765

G

PR/SET domain 1

increases expression

trovafloxacin results in increased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488

G

PR/SET domain 13

decreases expression

trovafloxacin results in decreased expression of PRDM13 mRNA

NCBI chr 5:40,017,607...40,029,658
Ensembl chr 5:35,225,435...35,232,881

G

prolactin regulatory element binding

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PREB mRNA

NCBI chr 6:31,138,757...31,142,544
Ensembl chr 6:25,418,776...25,422,590

G

prickle planar cell polarity protein 2

decreases expression

trovafloxacin results in decreased expression of PRICKLE2 mRNA

NCBI chr 4:126,426,767...126,771,986
Ensembl chr 4:124,869,552...125,214,824

G

DNA primase subunit 1

decreases expression

trovafloxacin results in decreased expression of PRIM1 mRNA

NCBI chr 7:1,031,436...1,047,134
Ensembl chr 7:431,805...462,526

G

DNA primase subunit 2

decreases expression

trovafloxacin results in decreased expression of PRIM2 mRNA

NCBI chr 9:43,188,350...43,400,482
Ensembl chr 9:35,692,376...35,903,030

G

protein kinase cAMP-dependent type I regulatory subunit beta

decreases expression

trovafloxacin results in decreased expression of PRKAR1B mRNA

NCBI chr12:20,606,066...20,738,766
Ensembl chr12:15,511,801...15,624,942

G

protein kinase C, gamma

increases expression

trovafloxacin results in increased expression of PRKCG mRNA

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

trovafloxacin results in decreased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952

G

protein kinase cGMP-dependent 2

decreases expression

trovafloxacin results in decreased expression of PRKG2 mRNA

NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,559,882...10,666,888

G

PRKR interacting protein 1

increases expression

trovafloxacin results in increased expression of PRKRIP1 mRNA

NCBI chr12:26,107,422...26,128,404
Ensembl chr12:20,470,820...20,489,115

G

protein arginine methyltransferase 6

increases expression

trovafloxacin results in increased expression of PRMT6 mRNA

NCBI chr 2:200,615,780...200,620,790
Ensembl chr 2:197,927,220...197,933,648

G

protein C receptor

increases expression

trovafloxacin results in increased expression of PROCR mRNA

NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:144,254,380...144,258,903

G

prokineticin receptor 1

increases expression

trovafloxacin results in increased expression of PROKR1 mRNA

NCBI chr 4:121,579,630...121,590,695
Ensembl chr 4:120,021,747...120,033,379

G

proline and serine rich 2

increases expression

trovafloxacin results in increased expression of PROSER2 mRNA

NCBI chr17:77,061,371...77,096,788
Ensembl chr17:72,151,872...72,185,825

G

proline and serine rich 3

decreases expression

trovafloxacin results in decreased expression of PROSER3 mRNA

NCBI chr 1:85,793,363...85,806,682
Ensembl chr 1:85,793,358...85,805,909

G

prospero homeobox 2

decreases expression

trovafloxacin results in decreased expression of PROX2 mRNA

NCBI chr 6:110,460,074...110,489,684
Ensembl chr 6:104,733,002...104,742,093

G

pre-mRNA processing factor 3

increases expression

trovafloxacin results in increased expression of PRPF3 mRNA

NCBI chr 2:186,067,980...186,092,427
Ensembl chr 2:183,378,718...183,403,489

G

pre-mRNA processing factor 39

increases expression

trovafloxacin results in increased expression of PRPF39 mRNA

NCBI chr 6:88,825,227...88,851,342
Ensembl chr 6:83,088,986...83,113,825

G

proline rich 7 (synaptic)

increases expression

trovafloxacin results in increased expression of PRR7 mRNA

NCBI chr17:9,170,405...9,178,814
Ensembl chr17:9,165,269...9,172,536

G

serine protease 16

decreases expression

trovafloxacin results in decreased expression of PRSS16 mRNA

NCBI chr17:47,210,071...47,225,377
Ensembl chr17:42,514,306...42,521,884

G

serine protease 23

decreases expression

trovafloxacin results in decreased expression of PRSS23 mRNA

NCBI chr 1:152,815,301...152,835,005
Ensembl chr 1:143,401,396...143,422,091

G

serine protease 36

decreases expression

trovafloxacin results in decreased expression of PRSS36 mRNA

NCBI chr 1:191,973,556...192,002,231
Ensembl chr 1:182,543,085...182,559,280

G

phosphoserine aminotransferase 1

decreases expression

trovafloxacin results in decreased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:213,196,709...213,218,682

G

pleckstrin and Sec7 domain containing

increases expression

trovafloxacin results in increased expression of PSD mRNA

NCBI chr 1:255,114,703...255,130,151
Ensembl chr 1:245,173,279...245,189,356

G

presenilin enhancer gamma secretase subunit

increases expression

trovafloxacin results in increased expression of PSENEN mRNA

NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:85,814,905...85,816,192

G

PC4 and SRSF1 interacting protein 1

decreases expression

trovafloxacin results in decreased expression of PSIP1 mRNA

NCBI chr 5:102,892,929...102,925,191
Ensembl chr 5:97,847,015...97,879,257

G

proteasome 20S subunit alpha 5

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PSMA5 mRNA

NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 20S subunit beta 10

decreases expression

trovafloxacin results in decreased expression of PSMB10 mRNA

NCBI chr19:50,740,808...50,743,292
Ensembl chr19:33,827,229...33,833,626

G

phosphoserine phosphatase

decreases expression

trovafloxacin results in decreased expression of PSPH mRNA

NCBI chr12:32,527,091...32,541,182
Ensembl chr12:26,883,133...26,905,074

G

polypyrimidine tract binding protein 2

increases expression

trovafloxacin results in increased expression of PTBP2 mRNA

NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:207,812,920...207,873,506

G

phosphatase and tensin homolog

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E receptor 1

increases expression

trovafloxacin results in increased expression of PTGER1 mRNA

NCBI chr19:41,374,983...41,379,593
Ensembl chr19:24,467,532...24,473,559

G

prostaglandin reductase 2

decreases expression

trovafloxacin results in decreased expression of PTGR2 mRNA

NCBI chr 6:109,662,469...109,694,232
Ensembl chr 6:103,931,409...103,963,111

G

prostaglandin-endoperoxide synthase 2

increases expression

trovafloxacin results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

prothymosin alpha

decreases expression

trovafloxacin results in decreased expression of PTMA mRNA

NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:87,176,230...87,180,333

G

parathymosin

decreases expression

trovafloxacin results in decreased expression of PTMS mRNA

NCBI chr 4:159,408,647...159,412,837
Ensembl chr 4:157,722,386...157,727,009

G

protein tyrosine phosphatase 4A1

increases expression
multiple interactions

trovafloxacin results in increased expression of PTP4A1 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTP4A1 mRNA

PMID:18930950 PMID:24136188

NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:33,214,208...33,221,964

G

protein tyrosine phosphatase, non-receptor type 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PTPN2 mRNA

NCBI chr18:63,498,890...63,564,571
Ensembl chr18:61,229,014...61,294,627

G

protein tyrosine phosphatase, non-receptor type 21

decreases expression

trovafloxacin results in decreased expression of PTPN21 mRNA

NCBI chr 6:123,662,783...123,727,809
Ensembl chr 6:117,933,066...117,998,095

G

protein tyrosine phosphatase, non-receptor type 5

decreases expression

trovafloxacin results in decreased expression of PTPN5 mRNA

NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

trovafloxacin results in decreased expression of PTS mRNA

NCBI chr 8:59,767,234...59,774,265
Ensembl chr 8:50,870,841...50,877,869

G

PTTG1 regulator of sister chromatid separation, securin

decreases expression

trovafloxacin results in decreased expression of PTTG1 mRNA

PMID:24136188 PMID:35537566

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:27,893,689...27,904,837

G

Pvt1 oncogene

increases expression

trovafloxacin results in increased expression of PVT1 mRNA

NCBI chr 7:95,545,916...95,769,306

G

peroxisomal membrane protein 2

decreases expression

trovafloxacin results in decreased expression of PXMP2 mRNA

NCBI chr12:52,053,951...52,064,283
Ensembl chr12:46,394,193...46,404,557

G

pyrroline-5-carboxylate reductase 1

decreases expression

trovafloxacin results in decreased expression of PYCR1 mRNA

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:105,917,680...105,922,549

G

glutaminyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of QARS1 mRNA

NCBI chr 8:118,086,243...118,094,274
Ensembl chr 8:109,207,705...109,215,739

G

RAB11 family interacting protein 4

decreases expression

trovafloxacin results in decreased expression of RAB11FIP4 mRNA

NCBI chr10:65,048,070...65,156,086
Ensembl chr10:64,550,177...64,654,759

G

RAB32, member RAS oncogene family

decreases expression

trovafloxacin results in decreased expression of RAB32 mRNA

NCBI chr 1:6,766,448...6,781,258
Ensembl chr 1:4,945,036...4,960,934

G

Rab7b, member RAS oncogene family

increases expression

trovafloxacin results in increased expression of RAB7B mRNA

NCBI chr13:45,673,396...45,699,798
Ensembl chr13:43,121,226...43,147,581

G

Rab geranylgeranyltransferase subunit beta

increases expression

trovafloxacin results in increased expression of RABGGTB mRNA

NCBI chr 2:245,504,586...245,510,878
Ensembl chr 2:242,844,762...242,851,050

G

Rac family small GTPase 3

increases expression

trovafloxacin results in increased expression of RAC3 mRNA

NCBI chr10:106,501,133...106,503,569
Ensembl chr10:105,993,087...106,005,260

G

Rac GTPase-activating protein 1

decreases expression

trovafloxacin results in decreased expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:130,750,936...130,780,831

G

RAD23 homolog A, nucleotide excision repair protein

decreases expression

trovafloxacin results in decreased expression of RAD23A mRNA

NCBI chr19:40,219,235...40,225,543
Ensembl chr19:23,314,797...23,320,695

G

RAD50 double strand break repair protein

decreases expression

trovafloxacin results in decreased expression of RAD50 mRNA

NCBI chr10:38,310,147...38,362,100
Ensembl chr10:37,808,726...37,861,396

G

RAD51 recombinase

decreases expression

trovafloxacin results in decreased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD51 associated protein 1

decreases expression

trovafloxacin results in decreased expression of RAD51AP1 mRNA

NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:159,759,459...159,772,524

G

RAD51 paralog B

decreases expression

trovafloxacin results in decreased expression of RAD51B mRNA

NCBI chr 6:103,829,390...104,373,923
Ensembl chr 6:98,098,868...98,640,979

G

RAD51 paralog C

decreases expression

trovafloxacin results in decreased expression of RAD51C mRNA

NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248

G

RAD54 homolog B

decreases expression

trovafloxacin results in decreased expression of RAD54B mRNA

NCBI chr 5:29,829,465...29,901,967
Ensembl chr 5:25,032,066...25,104,616

G

RAD54 like

decreases expression

trovafloxacin results in decreased expression of RAD54L mRNA

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:129,575,378...129,605,070

G

RPA1 related single stranded DNA binding protein, X-linked

decreases expression

trovafloxacin results in decreased expression of RADX mRNA

NCBI chr X:107,877,835...107,965,476
Ensembl chr X:103,089,284...103,176,838

G

Ral GTPase activating protein catalytic subunit alpha 2

decreases expression

trovafloxacin results in decreased expression of RALGAPA2 mRNA

NCBI chr 3:154,112,005...154,392,070
Ensembl chr 3:133,659,761...133,938,916

G

RAN, member RAS oncogene family

decreases expression

trovafloxacin results in decreased expression of RAN mRNA

NCBI chr12:33,311,155...33,314,339
Ensembl chr12:27,674,050...27,678,276

G

RAN binding protein 3-like

decreases expression

trovafloxacin results in decreased expression of RANBP3L mRNA

NCBI chr 2:59,785,070...59,840,338
Ensembl chr 2:58,058,263...58,113,172

G

RAN binding protein 6

increases expression

trovafloxacin results in increased expression of RANBP6 mRNA

NCBI chr 1:236,985,930...236,990,451
Ensembl chr 1:227,572,105...227,576,942

G

RAN GTPase activating protein 1

decreases expression

trovafloxacin results in decreased expression of RANGAP1 mRNA

NCBI chr 7:115,104,820...115,130,564
Ensembl chr 7:113,224,703...113,250,438

G

retinoic acid receptor, beta

decreases expression

trovafloxacin results in decreased expression of RARB mRNA

NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288

G

RAS protein activator like 1

decreases expression

trovafloxacin results in decreased expression of RASAL1 mRNA

NCBI chr12:41,541,865...41,574,957
Ensembl chr12:35,881,270...35,913,727

G

RasGEF domain family, member 1B

increases expression

trovafloxacin results in increased expression of RASGEF1B mRNA

NCBI chr14:10,164,366...10,684,184
Ensembl chr14:9,860,247...10,379,741

G

Ras association domain family member 1

increases expression

trovafloxacin results in increased expression of RASSF1 mRNA

NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:108,225,023...108,236,164

G

Ras association domain family member 8

increases expression

trovafloxacin results in increased expression of RASSF8 mRNA

NCBI chr 4:180,447,050...180,528,792
Ensembl chr 4:178,719,992...178,796,690

G

RB transcriptional corepressor 1

decreases expression

trovafloxacin results in decreased expression of RB1 mRNA

PMID:24136188 PMID:35537566

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RB1-inducible coiled-coil 1

multiple interactions
increases expression

TNF protein inhibits the reaction [trovafloxacin results in increased expression of RB1CC1 mRNA]

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:13,161,648...13,225,560

G

RB-associated KRAB zinc finger

increases expression

trovafloxacin results in increased expression of RBAK mRNA

NCBI chr12:16,488,895...16,502,523
Ensembl chr12:11,375,318...11,388,934

G

RB binding protein 8, endonuclease

decreases expression

trovafloxacin results in decreased expression of RBBP8 mRNA

NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846

G

RB transcriptional corepressor like 1

decreases expression

trovafloxacin results in decreased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330

G

RNA binding motif protein 18

increases expression

trovafloxacin results in increased expression of RBM18 mRNA

NCBI chr 3:39,864,739...39,884,577
Ensembl chr 3:19,467,335...19,487,178

G

ring-box 1

increases expression

trovafloxacin results in increased expression of RBX1 mRNA

NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:112,990,835...113,001,051

G

ring finger and CCCH-type domains 1

increases expression

trovafloxacin results in increased expression of RC3H1 mRNA

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839

G

regulator of calcineurin 1

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RCAN1 mRNA
trovafloxacin results in increased expression of RCAN1 mRNA

PMID:18930950 PMID:35537566

NCBI chr11:45,108,123...45,188,065
Ensembl chr11:31,622,210...31,702,045

G

RCC1 and BTB domain containing protein 1

decreases expression

trovafloxacin results in decreased expression of RCBTB1 mRNA

NCBI chr15:37,430,453...37,477,920
Ensembl chr15:33,319,586...33,365,302

G

retinol dehydrogenase 12

decreases expression

trovafloxacin results in decreased expression of RDH12 mRNA

NCBI chr 6:103,748,457...103,761,379
Ensembl chr 6:98,015,465...98,028,388

G

retinol dehydrogenase 14

decreases expression

trovafloxacin results in decreased expression of RDH14 mRNA

NCBI chr 6:38,875,693...38,880,836
Ensembl chr 6:33,156,569...33,161,712

G

RAD52 motif containing 1

decreases expression

trovafloxacin results in decreased expression of RDM1 mRNA

NCBI chr10:87,062,322...87,073,273
Ensembl chr10:86,539,553...86,573,034

G

radixin

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RDX mRNA

NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:52,379,494...52,437,678

G

RecQ like helicase 4

decreases expression

trovafloxacin results in decreased expression of RECQL4 mRNA

NCBI chr 7:110,304,092...110,311,426
Ensembl chr 7:108,423,455...108,430,619

G

receptor accessory protein 6

decreases expression

trovafloxacin results in decreased expression of REEP6 mRNA

PMID:24136188 PMID:35537566

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:9,373,927...9,380,597

G

REL proto-oncogene, NF-kB subunit

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of REL mRNA

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

trovafloxacin affects the reaction [TNF protein affects the localization of RELA protein modified form]; trovafloxacin affects the reaction [TNF protein results in increased phosphorylation of RELA protein]
trovafloxacin affects the localization of RELA protein
trovafloxacin affects the reaction [Lipopolysaccharides affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

RELT-like 1

decreases expression

trovafloxacin results in decreased expression of RELL1 mRNA

NCBI chr14:44,672,121...44,732,081
Ensembl chr14:44,303,009...44,378,500

G

replication factor C subunit 2

decreases expression

trovafloxacin results in decreased expression of RFC2 mRNA

NCBI chr12:27,756,920...27,770,049
Ensembl chr12:22,120,010...22,133,557

G

replication factor C subunit 5

decreases expression

trovafloxacin results in decreased expression of RFC5 mRNA

NCBI chr12:44,868,322...44,877,879
Ensembl chr12:39,207,484...39,217,312

G

RFT1 homolog

decreases expression

trovafloxacin results in decreased expression of RFT1 mRNA

NCBI chr16:5,833,521...5,867,578
Ensembl chr16:5,827,088...5,861,120

G

regulatory factor X2

decreases expression

trovafloxacin results in decreased expression of RFX2 mRNA

NCBI chr 9:1,691,762...1,759,159
Ensembl chr 9:1,604,646...1,671,027

G

regulator of cell cycle

increases expression

trovafloxacin results in increased expression of RGCC mRNA

NCBI chr15:61,071,574...61,084,408
Ensembl chr15:54,662,483...54,681,141

G

regulator of G-protein signaling 1

increases expression

trovafloxacin results in increased expression of RGS1 mRNA

NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984

G

regulator of G-protein signaling 16

increases expression

trovafloxacin results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857

G

regulator of G-protein signaling 2

increases expression

trovafloxacin results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385

G

regulator of G-protein signaling 20

increases expression

trovafloxacin results in increased expression of RGS20 mRNA

NCBI chr 5:19,282,249...19,412,122
Ensembl chr 5:14,534,775...14,614,084

G

rhomboid domain containing 3

increases expression
decreases expression

trovafloxacin results in increased expression of RHBDD3 mRNA
trovafloxacin results in decreased expression of RHBDD3 mRNA

NCBI chr14:84,208,155...84,214,334
Ensembl chr14:79,994,158...80,000,175

G

rhomboid 5 homolog 1

increases expression

trovafloxacin results in increased expression of RHBDF1 mRNA

NCBI chr10:15,911,282...15,924,214
Ensembl chr10:15,406,859...15,419,763

G

rhomboid like 1

increases expression

trovafloxacin results in increased expression of RHBDL1 mRNA

NCBI chr10:15,359,027...15,362,530
Ensembl chr10:14,854,514...14,857,430

G

ras homolog family member D

increases expression

trovafloxacin results in increased expression of RHOD mRNA

NCBI chr 1:211,138,126...211,153,953
Ensembl chr 1:201,708,699...201,722,632

G

ras homolog family member J

decreases expression

trovafloxacin results in decreased expression of RHOJ mRNA

NCBI chr 6:99,771,104...99,853,366
Ensembl chr 6:94,035,483...94,118,275

G

ras homolog family member Q

decreases expression

trovafloxacin results in decreased expression of RHOQ mRNA

NCBI chr 6:13,368,499...13,403,929
Ensembl chr 1:106,622,141...106,623,699

G

ras homolog family member V

increases expression

trovafloxacin results in increased expression of RHOV mRNA

NCBI chr 3:126,714,608...126,723,617
Ensembl chr 3:106,260,776...106,269,479

G

RIC8 guanine nucleotide exchange factor A

decreases expression

trovafloxacin results in decreased expression of RIC8A mRNA

NCBI chr 1:205,364,796...205,371,102
Ensembl chr 1:195,935,349...195,941,467

G

RIPOR family member 3

decreases expression

trovafloxacin results in decreased expression of FAM65C mRNA

NCBI chr 3:177,106,436...177,179,423
Ensembl chr 3:156,687,517...156,715,061

G

regulator of microtubule dynamics 1

decreases expression

trovafloxacin results in decreased expression of RMDN1 mRNA

NCBI chr 5:37,867,172...37,890,826
Ensembl chr 5:33,070,265...33,127,328

G

regulator of microtubule dynamics 2

decreases expression

trovafloxacin results in decreased expression of RMDN2 mRNA

NCBI chr 6:21,101,383...21,195,221
Ensembl chr 6:15,375,496...15,441,480

G

RecQ mediated genome instability 2

decreases expression

trovafloxacin results in decreased expression of RMI2 mRNA

NCBI chr10:5,336,269...5,344,202
Ensembl chr10:4,830,553...4,837,235

G

required for meiotic nuclear division 1 homolog

decreases expression

trovafloxacin results in decreased expression of RMND1 mRNA

NCBI chr 1:43,265,207...43,299,748
Ensembl chr 1:40,859,829...40,894,314

G

ribonuclease H2, subunit C

decreases expression

trovafloxacin results in decreased expression of RNASEH2C mRNA

NCBI chr 1:212,323,916...212,325,011
Ensembl chr 1:202,894,643...202,897,516

G

Rho family GTPase 1

decreases expression

trovafloxacin results in decreased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399

G

Rho family GTPase 3

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of RND3 mRNA
trovafloxacin results in decreased expression of RND3 mRNA

PMID:18930950 PMID:35537566

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 145

increases expression

trovafloxacin results in increased expression of RNF145 mRNA

NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,011,548...29,050,781

G

ring finger protein 151

increases expression

trovafloxacin results in increased expression of RNF151 mRNA

NCBI chr10:14,247,215...14,251,738
Ensembl chr10:13,742,682...13,745,000

G

ring finger protein 157

decreases expression

trovafloxacin results in decreased expression of RNF157 mRNA

NCBI chr10:102,070,842...102,138,738
Ensembl chr10:101,566,295...101,639,942

G

ring finger protein 180

decreases expression

trovafloxacin results in decreased expression of RNF180 mRNA

NCBI chr 2:38,064,026...38,244,854
Ensembl chr 2:36,330,292...36,512,614

G

ring finger protein 183

increases expression

trovafloxacin results in increased expression of RNF183 mRNA

NCBI chr 5:80,892,683...80,914,037
Ensembl chr 5:75,876,003...75,886,191

G

ring finger protein 26

decreases expression

trovafloxacin results in decreased expression of RNF26 mRNA

NCBI chr 8:53,351,388...53,353,586
Ensembl chr 8:44,454,292...44,457,331

G

ring finger protein 39

increases expression

trovafloxacin results in increased expression of RNF39 mRNA

NCBI chr20:1,610,027...1,615,516
Ensembl chr20:1,604,794...1,610,283

G

ring finger protein 6

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of RNF6 mRNA

NCBI chr12:13,929,160...13,940,663
Ensembl chr12:8,816,833...8,826,847

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

trovafloxacin results in decreased expression of ROCK2 mRNA

NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031

G

RAR-related orphan receptor A

decreases expression

trovafloxacin results in decreased expression of RORA mRNA

NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:69,301,733...70,025,931

G

replication protein A1

decreases expression

trovafloxacin results in decreased expression of RPA1 mRNA

NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,148,793...60,199,949

G

RPA interacting protein

decreases expression

trovafloxacin results in decreased expression of RPAIN mRNA

NCBI chr10:56,190,975...56,198,490
Ensembl chr10:55,692,417...55,699,933

G

ribosomal protein L10A

increases expression

trovafloxacin results in increased expression of RPL10A mRNA

NCBI chr20:6,390,533...6,393,091
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L18

increases expression

trovafloxacin results in increased expression of RPL18 mRNA

NCBI chr 1:105,325,269...105,327,911
Ensembl chr 1:96,188,112...96,191,452

G

ribosomal protein L3-like

increases expression

trovafloxacin results in increased expression of RPL3L mRNA

NCBI chr10:14,258,446...14,268,989
Ensembl chr10:13,753,886...13,764,457

G

ribosomal protein L7-like 1

decreases expression
increases expression

trovafloxacin results in decreased expression of RPL7L1 mRNA
trovafloxacin results in increased expression of RPL7L1 mRNA

PMID:24136188 PMID:35537566

NCBI chr 9:21,695,718...21,703,736
Ensembl chr 9:14,198,092...14,206,110

G

ribonuclease P RNA component H1

increases expression

trovafloxacin results in increased expression of RPPH1 mRNA

NCBI chr15:26,507,232...26,507,488
Ensembl chr15:24,033,662...24,033,959

G

ribosomal protein S27-like

increases expression

trovafloxacin results in increased expression of RPS27L mRNA

NCBI chr 8:76,443,658...76,448,593
Ensembl chr 8:67,562,483...67,567,418
Ensembl chr12:67,562,483...67,567,418
Ensembl chr 2:67,562,483...67,567,418

G

ribosomal protein S6 kinase A2

decreases expression

trovafloxacin results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:52,631,736...52,906,739

G

ribosomal protein S6 kinase A4

decreases expression

trovafloxacin results in decreased expression of RPS6KA4 mRNA

NCBI chr 1:213,451,026...213,461,982
Ensembl chr 1:204,021,806...204,032,761

G

ribosomal protein S6 kinase B1

multiple interactions

[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

ribonucleotide reductase catalytic subunit M1

decreases expression

trovafloxacin results in decreased expression of RRM1 mRNA

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

decreases expression

trovafloxacin results in decreased expression of RRM2 mRNA

PMID:24136188 PMID:35537566

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

increases expression

trovafloxacin results in increased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699

G

round spermatid basic protein 1

increases expression

trovafloxacin results in increased expression of RSBN1 mRNA

NCBI chr 2:194,105,058...194,159,142
Ensembl chr 2:191,416,631...191,470,711

G

arginine and serine rich protein 1

increases expression

trovafloxacin results in increased expression of RSRP1 mRNA

NCBI chr 5:152,431,448...152,435,202
Ensembl chr 5:147,147,784...147,151,523

G

RT1 class I, locus CE16

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563

G

regulator of telomere elongation helicase 1

decreases expression

trovafloxacin results in decreased expression of RTEL1 mRNA

NCBI chr 3:188,778,329...188,842,877
Ensembl chr 3:168,419,579...168,465,348

G

rhotekin 2

decreases expression

trovafloxacin results in decreased expression of RTKN2 mRNA

NCBI chr20:20,535,553...20,608,863
Ensembl chr20:20,525,256...20,609,951

G

receptor (chemosensory) transporter protein 4

increases expression

trovafloxacin results in increased expression of RTP4 mRNA

NCBI chr11:90,741,992...90,840,061
Ensembl chr11:77,238,216...77,335,437

G

rotatin

decreases expression

trovafloxacin results in decreased expression of RTTN mRNA

NCBI chr18:84,495,813...84,673,079
Ensembl chr18:82,221,050...82,398,333

G

rubicon like autophagy enhancer

decreases expression

trovafloxacin results in decreased expression of RUBCNL mRNA

NCBI chr15:56,741,897...56,807,086
Ensembl chr15:50,332,418...50,400,849

G

RUN domain containing 1

increases expression

trovafloxacin results in increased expression of RUNDC1 mRNA

NCBI chr10:86,361,635...86,375,446
Ensembl chr10:86,361,051...86,370,878

G

RUNX family transcription factor 2

decreases expression

trovafloxacin results in decreased expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167

G

RWD domain containing 2A

decreases expression

trovafloxacin results in decreased expression of RWDD2A mRNA

NCBI chr 8:96,416,190...96,419,315
Ensembl chr 8:87,536,176...87,539,300

G

S100 calcium binding protein A11

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of S100A11 mRNA

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium binding protein A3

increases expression

trovafloxacin results in increased expression of S100A3 mRNA

NCBI chr 2:178,331,856...178,387,280
Ensembl chr 2:176,049,520...176,089,702

G

sphingosine-1-phosphate receptor 1

decreases expression

trovafloxacin results in decreased expression of S1PR1 mRNA

NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681

G

SUMO1 activating enzyme subunit 1

decreases expression

trovafloxacin results in decreased expression of SAE1 mRNA

NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:77,030,965...77,086,986

G

sterile alpha motif domain containing 9 like

increases expression

trovafloxacin results in increased expression of SAMD9L mRNA

NCBI chr 4:32,316,748...32,331,112
Ensembl chr 4:31,361,669...31,376,415

G

suppressor APC domain containing 2

decreases expression

trovafloxacin results in decreased expression of SAPCD2 mRNA

NCBI chr 3:28,583,615...28,590,694
Ensembl chr 3:8,187,266...8,192,546

G

SAP domain containing ribonucleoprotein

decreases expression

trovafloxacin results in decreased expression of SARNP mRNA

NCBI chr 7:1,835,597...1,889,833
Ensembl chr 7:1,251,098...1,305,332

G

SAM and SH3 domain containing 3

decreases expression

trovafloxacin results in decreased expression of SASH3 mRNA

NCBI chr X:132,204,717...132,219,421
Ensembl chr X:127,326,859...127,341,519

G

spermidine/spermine N1-acetyl transferase 1

increases expression

trovafloxacin results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813

G

Sbds, ribosome maturation factor

increases expression

trovafloxacin results in increased expression of SBDS mRNA

NCBI chr12:32,056,649...32,065,816
Ensembl chr12:26,420,414...26,429,649

G

SREBF chaperone

decreases expression

trovafloxacin results in decreased expression of SCAP mRNA

NCBI chr 8:119,184,366...119,239,086
Ensembl chr 8:110,306,031...110,360,666

G

stearoyl-CoA desaturase

decreases expression

trovafloxacin results in decreased expression of SCD1 mRNA

PMID:24136188 PMID:35537566

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

stearoyl-coenzyme A desaturase 4

decreases expression

trovafloxacin results in decreased expression of SCD4 mRNA

NCBI chr 1:253,152,519...253,165,216
Ensembl chr 1:243,203,881...243,215,148

G

sciellin

decreases expression

trovafloxacin results in decreased expression of SCEL mRNA

NCBI chr15:86,754,595...86,871,200
Ensembl chr15:80,339,951...80,456,372

G

scinderin

increases expression

trovafloxacin results in increased expression of SCIN mRNA

NCBI chr 6:62,836,641...62,915,287
Ensembl chr 6:57,109,403...57,188,242

G

sodium channel and clathrin linker 1

decreases expression

trovafloxacin results in decreased expression of SCLT1 mRNA

NCBI chr 2:126,533,436...126,691,879
Ensembl chr 2:124,605,658...124,764,065

G

selenocysteine lyase

decreases expression

trovafloxacin results in decreased expression of SCLY mRNA

NCBI chr 9:99,337,796...99,358,487
Ensembl chr 9:91,890,306...91,910,941

G

Scm polycomb group protein like 4

decreases expression

trovafloxacin results in decreased expression of SCML4 mRNA

NCBI chr20:47,929,539...48,023,419
Ensembl chr20:46,347,413...46,440,103

G

sodium voltage-gated channel alpha subunit 11

decreases expression

trovafloxacin results in decreased expression of SCN11A mRNA

NCBI chr 8:128,374,441...128,444,718
Ensembl chr 8:119,496,769...119,567,044

G

secernin 2

decreases expression

trovafloxacin results in decreased expression of SCRN2 mRNA

NCBI chr10:82,513,043...82,517,115
Ensembl chr10:82,016,649...82,020,675

G

stromal cell-derived factor 2-like 1

decreases expression

trovafloxacin results in decreased expression of SDF2L1 mRNA

NCBI chr11:97,376,878...97,379,120
Ensembl chr11:83,872,659...83,874,902

G

serine dehydratase

increases expression

trovafloxacin results in increased expression of SDS mRNA

NCBI chr12:41,743,796...41,751,108
Ensembl chr12:36,083,229...36,088,203

G

SEC24 homolog D, COPII coat complex component

decreases expression

trovafloxacin results in decreased expression of SEC24D mRNA

NCBI chr 2:214,103,138...214,211,155
Ensembl chr 2:211,418,623...211,526,587

G

selectin E

multiple interactions

[trovafloxacin co-treated with IL1B protein] affects the localization of SELE protein; [trovafloxacin co-treated with IL1B protein] results in increased expression of SELE mRNA; trovafloxacin promotes the reaction [IL1B protein results in increased secretion of SELE protein]
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SELE mRNA

PMID:10822086 PMID:18930950

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741

G

selenium binding protein 1

decreases expression

trovafloxacin results in decreased expression of SELENBP1 mRNA

NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594

G

selectin L

decreases expression

trovafloxacin results in decreased expression of SELL mRNA

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

semaphorin 3E

decreases expression

trovafloxacin results in decreased expression of SEMA3E mRNA

NCBI chr 4:21,252,686...21,510,449
Ensembl chr 4:20,299,718...20,555,229

G

semaphorin 4B

increases expression

trovafloxacin results in increased expression of SEMA4B mRNA

NCBI chr 1:143,545,727...143,587,037
Ensembl chr 1:134,149,536...134,177,775

G

semaphorin 6D

increases expression

trovafloxacin results in increased expression of SEMA6D mRNA

NCBI chr 3:131,801,680...132,394,578
Ensembl chr 3:111,883,872...111,941,094

G

SUMO specific peptidase 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SENP2 mRNA

NCBI chr11:92,487,259...92,522,795
Ensembl chr11:78,981,432...79,018,238

G

SUMO peptidase family member, NEDD8 specific

decreases expression

trovafloxacin results in decreased expression of SENP8 mRNA

NCBI chr 8:69,031,230...69,044,616
Ensembl chr 8:60,121,714...60,148,928

G

septin 10

decreases expression

trovafloxacin results in decreased expression of SEPTIN10 mRNA

NCBI chr20:27,644,862...27,737,817
Ensembl chr20:27,101,752...27,194,780

G

serpin family B member 12

decreases expression

trovafloxacin results in decreased expression of SERPINB12 mRNA

NCBI chr13:23,567,023...23,598,329
Ensembl chr13:23,052,448...23,083,691

G

serpin family E member 1

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SERPINE1 mRNA; SERPINE1 protein results in increased susceptibility to [trovafloxacin co-treated with Lipopolysaccharides]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]
trovafloxacin results in increased expression of SERPINE1 mRNA

PMID:18930950 PMID:19367693 PMID:35537566

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

serpin family F member 1

decreases expression

trovafloxacin results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646

G

SET domain containing 6, protein lysine methyltransferase

decreases expression

trovafloxacin results in decreased expression of SETD6 mRNA

NCBI chr19:9,349,011...9,356,515
Ensembl chr19:9,347,458...9,350,453

G

splicing factor 3a, subunit 3

decreases expression

trovafloxacin results in decreased expression of SF3A3 mRNA

NCBI chr 5:142,246,556...142,272,053
Ensembl chr 5:136,967,691...136,987,361

G

splicing factor proline and glutamine rich

decreases expression

trovafloxacin results in decreased expression of SFPQ mRNA

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:139,338,075...139,353,472

G

sarcoglycan, beta

decreases expression

trovafloxacin results in decreased expression of SGCB mRNA

NCBI chr14:34,917,663...34,932,661
Ensembl chr14:34,563,608...34,578,583

G

SAGA complex associated factor 29

decreases expression

trovafloxacin results in decreased expression of SGF29 mRNA

NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:181,238,468...181,274,781

G

serum/glucocorticoid regulated kinase 1

decreases expression

trovafloxacin results in decreased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

shugoshin 1

decreases expression

trovafloxacin results in decreased expression of SGO1 mRNA

NCBI chr 9:6,908,661...6,943,483
Ensembl chr 9:6,672,123...6,687,805

G

shugoshin 2

decreases expression

trovafloxacin results in decreased expression of SGO2A mRNA

NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229

G

SH2 domain containing 6

decreases expression

trovafloxacin results in decreased expression of SH2D6 mRNA

NCBI chr 4:106,124,378...106,132,337
Ensembl chr 4:104,566,211...104,574,118

G

SH3-domain binding protein 2

increases expression

trovafloxacin results in increased expression of SH3BP2 mRNA

NCBI chr14:80,400,685...80,437,887
Ensembl chr14:76,176,101...76,213,251

G

SH3-domain binding protein 5

increases expression

trovafloxacin results in increased expression of SH3BP5 mRNA

NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975

G

SHC adaptor protein 4

decreases expression

trovafloxacin results in decreased expression of SHC4 mRNA

NCBI chr 3:133,334,026...133,428,404
Ensembl chr 3:112,880,600...112,974,366

G

SHC binding and spindle associated 1

decreases expression

trovafloxacin results in decreased expression of SHCBP1 mRNA

NCBI chr16:91,373,843...91,405,409
Ensembl chr16:84,672,321...84,703,844

G

SHC binding and spindle associated 1 like

decreases expression

trovafloxacin results in decreased expression of SHCBP1L mRNA

NCBI chr13:68,118,861...68,149,646
Ensembl chr13:65,568,863...65,599,154

G

shisa family member 3

decreases expression

trovafloxacin results in decreased expression of SHISA3 mRNA

NCBI chr14:40,917,563...40,922,135
Ensembl chr14:40,563,673...40,568,244

G

serine hydroxymethyltransferase 1

decreases expression

trovafloxacin results in decreased expression of SHMT1 mRNA

NCBI chr10:45,968,959...45,990,341
Ensembl chr10:45,468,700...45,497,820

G

serine hydroxymethyltransferase 2

decreases expression

trovafloxacin results in decreased expression of SHMT2 mRNA

NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:63,358,961...63,364,236

G

siah E3 ubiquitin protein ligase 2

decreases expression

trovafloxacin results in decreased expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:142,914,003...142,931,950

G

salt-inducible kinase 1

increases expression

trovafloxacin results in increased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,396...9,958,991

G

SIX homeobox 1

increases expression

trovafloxacin results in increased expression of SIX1 mRNA

NCBI chr 6:97,482,617...97,487,853
Ensembl chr 6:91,746,739...91,751,975

G

SIX homeobox 5

increases expression

trovafloxacin results in increased expression of SIX5 mRNA

NCBI chr 1:87,868,859...87,873,929
Ensembl chr 1:78,741,367...78,745,890

G

spindle and kinetochore associated complex subunit 1

decreases expression

trovafloxacin results in decreased expression of SKA1 mRNA

NCBI chr18:70,069,957...70,080,303
Ensembl chr18:67,794,725...67,805,037

G

spindle and kinetochore associated complex subunit 3

decreases expression

trovafloxacin results in decreased expression of SKA3 mRNA

NCBI chr15:36,067,372...36,086,563
Ensembl chr15:31,951,825...31,971,010

G

SKI-like proto-oncogene

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SKIL mRNA

NCBI chr 2:114,175,534...114,203,663
Ensembl chr 2:112,247,051...112,275,080

G

src-like adaptor

decreases expression

trovafloxacin results in decreased expression of SLA mRNA

NCBI chr 7:100,423,467...100,473,840
Ensembl chr 7:98,535,368...98,584,648

G

SLAM family member 9

decreases expression

trovafloxacin results in decreased expression of SLAMF9 mRNA

NCBI chr13:87,474,290...87,477,108
Ensembl chr13:84,941,982...84,944,748

G

solute carrier family 11 member 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC11A2 mRNA

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 13 member 3

decreases expression

trovafloxacin results in decreased expression of SLC13A3 mRNA

NCBI chr 3:174,561,174...174,623,893
Ensembl chr 3:154,141,872...154,204,606

G

solute carrier family 17, member 2

increases expression

trovafloxacin results in increased expression of SLC17A2 mRNA

NCBI chr17:41,748,195...41,767,601
Ensembl chr17:41,319,701...41,336,325

G

solute carrier family 17 member 3

decreases expression
multiple interactions

trovafloxacin results in decreased expression of SLC17A3 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLC17A3 mRNA

PMID:18930950 PMID:24136188

NCBI chr17:41,698,679...41,729,057
Ensembl chr17:41,270,812...41,295,256

G

solute carrier family 17 member 5

decreases expression

trovafloxacin results in decreased expression of SLC17A5 mRNA

NCBI chr 8:88,274,497...88,309,734

G

solute carrier family 17 member 9

decreases expression

trovafloxacin results in decreased expression of SLC17A9 mRNA

NCBI chr 3:188,211,106...188,233,553
Ensembl chr 3:167,839,385...167,855,985

G

solute carrier family 18 member A2

decreases expression

trovafloxacin results in decreased expression of SLC18A2 mRNA

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 19 member 2

increases expression

trovafloxacin results in increased expression of SLC19A2 mRNA

NCBI chr13:79,135,118...79,149,316
Ensembl chr13:76,601,900...76,616,172

G

solute carrier family 1 member 4

decreases expression

trovafloxacin results in decreased expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 1 member 5

decreases expression

trovafloxacin results in decreased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 1

decreases expression

trovafloxacin results in decreased expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 23 member 1

increases expression

trovafloxacin results in increased expression of SLC23A1 mRNA

NCBI chr18:27,490,549...27,504,563
Ensembl chr18:27,216,281...27,230,697

G

solute carrier family 25 member 10

decreases expression

trovafloxacin results in decreased expression of SLC25A10 mRNA

NCBI chr10:106,264,396...106,271,895
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 25, member 38

increases expression

trovafloxacin results in increased expression of SLC25A38 mRNA

NCBI chr 8:128,713,180...128,725,968
Ensembl chr 8:119,835,634...119,848,332

G

solute carrier family 25, member 40

decreases expression

trovafloxacin results in decreased expression of SLC25A40 mRNA

NCBI chr 4:26,544,288...26,631,439
Ensembl chr 4:25,589,360...25,676,472

G

solute carrier family 27 member 3

increases expression

trovafloxacin results in increased expression of SLC27A3 mRNA

NCBI chr 2:178,150,835...178,155,503
Ensembl chr 2:175,853,241...175,857,909

G

solute carrier family 28 member 2

decreases expression

trovafloxacin results in decreased expression of SLC28A2 mRNA

NCBI chr 3:129,778,425...129,841,292
Ensembl chr 3:109,366,996...109,387,702

G

solute carrier family 29 member 1

decreases expression

trovafloxacin results in decreased expression of SLC29A1 mRNA

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:15,399,612...15,414,203

G

solute carrier family 2 member 8

decreases expression

trovafloxacin results in decreased expression of SLC2A8 mRNA

NCBI chr 3:36,672,589...36,682,206
Ensembl chr 3:16,274,925...16,284,464

G

solute carrier family 30 member 9

decreases expression

trovafloxacin results in decreased expression of SLC30A9 mRNA

NCBI chr14:41,170,164...41,224,861
Ensembl chr14:40,816,290...40,870,929

G

solute carrier family 34 member 2

decreases expression

trovafloxacin results in decreased expression of SLC34A2 mRNA

NCBI chr14:62,123,313...62,153,020
Ensembl chr14:57,910,480...57,930,436

G

solute carrier family 35, member E3

decreases expression

trovafloxacin results in decreased expression of SLC35E3 mRNA

NCBI chr 7:55,222,962...55,236,022
Ensembl chr 7:53,337,095...53,350,165

G

solute carrier family 35, member F1

decreases expression

trovafloxacin results in decreased expression of SLC35F1 mRNA

NCBI chr20:32,573,091...32,961,466
Ensembl chr20:32,030,368...32,418,611

G

solute carrier family 37 member 2

increases expression

trovafloxacin results in increased expression of SLC37A2 mRNA

NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:36,946,930...36,971,482

G

solute carrier family 38, member 7

decreases expression

trovafloxacin results in decreased expression of SLC38A7 mRNA

NCBI chr19:9,215,336...9,231,592
Ensembl chr19:9,209,257...9,225,454

G

solute carrier family 39 member 14

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39 member 4

decreases expression

trovafloxacin results in decreased expression of SLC39A4 mRNA

NCBI chr 7:110,214,017...110,218,202
Ensembl chr 7:108,333,381...108,337,553

G

solute carrier family 41 member 2

decreases expression

trovafloxacin results in decreased expression of SLC41A2 mRNA

NCBI chr 7:22,271,298...22,378,764
Ensembl chr 7:20,383,757...20,491,166

G

solute carrier family 43, member 3

decreases expression

trovafloxacin results in decreased expression of SLC43A3 mRNA

NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:70,009,313...70,029,749

G

solute carrier family 45, member 3

increases expression

trovafloxacin results in increased expression of SLC45A3 mRNA

NCBI chr13:45,959,467...45,979,763
Ensembl chr13:43,407,293...43,427,588

G

solute carrier family 45, member 4

decreases expression

trovafloxacin results in decreased expression of SLC45A4 mRNA

NCBI chr 7:107,370,826...107,459,163
Ensembl chr 7:105,481,792...105,550,170

G

solute carrier family 46 member 1

increases expression

trovafloxacin results in increased expression of SLC46A1 mRNA

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,361,486...63,368,848

G

solute carrier family 46, member 3

decreases expression

trovafloxacin results in decreased expression of SLC46A3 mRNA

NCBI chr12:12,176,776...12,193,256
Ensembl chr12:7,140,668...7,157,092

G

solute carrier family 49 member 3

increases expression

trovafloxacin results in increased expression of SLC49A3 mRNA

NCBI chr14:1,448,274...1,459,126
Ensembl chr14:1,305,680...1,314,132

G

solute carrier family 4 member 3

increases expression

trovafloxacin results in increased expression of SLC4A3 mRNA

NCBI chr 9:84,484,749...84,497,746
Ensembl chr 9:77,037,016...77,049,105

G

solute carrier family 4 member 8

decreases expression

trovafloxacin results in decreased expression of SLC4A8 mRNA

NCBI chr 7:133,742,830...133,818,056
Ensembl chr 7:131,864,102...131,931,051

G

solute carrier family 52 member 2

decreases expression

trovafloxacin results in decreased expression of SLC52A2 mRNA

NCBI chr 7:110,126,632...110,146,647
Ensembl chr 7:108,262,612...108,268,034

G

solute carrier family 6 member 4

increases expression

trovafloxacin results in increased expression of SLC6A4 mRNA

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 6 member 9

decreases expression

trovafloxacin results in decreased expression of SLC6A9 mRNA

NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:131,374,542...131,408,728

G

solute carrier family 7 member 1

decreases expression

trovafloxacin results in decreased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7 member 11

decreases expression

trovafloxacin results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SLC7A2 mRNA

NCBI chr16:58,115,991...58,174,256
Ensembl chr16:51,417,493...51,470,784

G

solute carrier family 7 member 5

decreases expression

trovafloxacin results in decreased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823

G

solute carrier family 9 member A9

decreases expression

trovafloxacin results in decreased expression of SLC9A9 mRNA

NCBI chr 8:104,112,279...104,675,944
Ensembl chr 8:95,232,905...95,796,318

G

solute carrier organic anion transporter family, member 1a4

increases expression

trovafloxacin results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SLCO1B3 mRNA

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 4a1

increases expression

trovafloxacin results in increased expression of SLCO4A1 mRNA

NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:167,559,316...167,578,305

G

schlafen family member 2

increases expression

trovafloxacin results in increased expression of SLFN2 mRNA

NCBI chr10:68,450,861...68,457,198
Ensembl chr10:67,953,171...67,959,458

G

schlafen family member 4

increases expression

trovafloxacin results in increased expression of SLFN4 mRNA

NCBI chr10:68,492,135...68,515,674
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138

G

schlafen family member 5

increases expression

trovafloxacin results in increased expression of SLFN5 mRNA

NCBI chr10:68,378,440...68,392,515
Ensembl chr10:67,880,009...67,893,109

G

SMAD family member 6

decreases expression

trovafloxacin results in decreased expression of SMAD6 mRNA

NCBI chr 8:73,345,457...73,414,985
Ensembl chr 8:64,450,114...64,519,763

G

SWI/SNF related BAF chromatin remodeling complex subunit D2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SMARCD2 mRNA

NCBI chr10:91,693,542...91,702,408
Ensembl chr10:91,193,752...91,204,341

G

SWI/SNF related BAF chromatin remodeling complex subunit D3

increases expression

trovafloxacin results in increased expression of SMARCD3 mRNA

NCBI chr 4:11,441,142...11,472,781
Ensembl chr 4:10,548,751...10,580,326

G

structural maintenance of chromosomes 2

decreases expression

trovafloxacin results in decreased expression of SMC2 mRNA

NCBI chr 5:71,592,428...71,648,636
Ensembl chr 5:66,807,011...66,853,242

G

structural maintenance of chromosomes 4

decreases expression

trovafloxacin results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:153,240,283...153,271,571

G

SMG7 nonsense mediated mRNA decay factor

increases expression

trovafloxacin results in increased expression of SMG7 mRNA

NCBI chr13:67,536,016...67,600,624
Ensembl chr13:64,987,434...65,050,582

G

small integral membrane protein 11

increases expression

trovafloxacin results in increased expression of SMIM11 mRNA

NCBI chr11:45,019,269...45,028,926
Ensembl chr11:31,532,764...31,543,002

G

small integral membrane protein 14

decreases expression

trovafloxacin results in decreased expression of SMIM14 mRNA

NCBI chr14:43,136,754...43,180,622
Ensembl chr14:42,783,332...42,829,760

G

small integral membrane protein 27

increases expression

trovafloxacin results in increased expression of SMIM27 mRNA

NCBI chr 5:55,399,637...55,400,304
Ensembl chr 5:55,398,723...55,400,869

G

small integral membrane protein 5

increases expression

trovafloxacin results in increased expression of SMIM5 mRNA

NCBI chr10:101,632,966...101,642,089
Ensembl chr10:101,134,033...101,139,813

G

small integral membrane protein 7

increases expression

trovafloxacin results in increased expression of SMIM7 mRNA

NCBI chr16:17,308,466...17,312,384
Ensembl chr16:17,273,258...17,278,336

G

survival motor neuron domain containing 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SMNDC1 mRNA

NCBI chr 1:262,395,034...262,406,104
Ensembl chr 1:252,389,673...252,401,616

G

sphingomyelin phosphodiesterase, acid-like 3B

decreases expression

trovafloxacin results in decreased expression of SMPDL3B mRNA

NCBI chr 5:150,228,607...150,250,688
Ensembl chr 5:144,944,636...144,966,720

G

smoothelin

decreases expression

trovafloxacin results in decreased expression of SMTN mRNA

NCBI chr14:82,622,223...82,644,525
Ensembl chr14:78,397,778...78,420,886

G

small nuclear RNA activating complex, polypeptide 4

increases expression

trovafloxacin results in increased expression of SNAPC4 mRNA

NCBI chr 3:29,580,157...29,598,440
Ensembl chr 3:9,182,067...9,199,518

G

staphylococcal nuclease and tudor domain containing 1

decreases expression

trovafloxacin results in decreased expression of SND1 mRNA

PMID:24136188 PMID:35537566

NCBI chr 4:58,060,689...58,459,926
Ensembl chr 4:57,095,208...57,530,843

G

small nucleolar RNA, H/ACA box 23

increases expression

trovafloxacin results in increased expression of SNORA23 mRNA

NCBI chr 1:164,091,024...164,091,206
Ensembl chr 1:164,091,024...164,091,206

G

small nucleolar RNA, H/ACA box 31

increases expression

trovafloxacin results in increased expression of SNORA31 mRNA

NCBI chr15:57,568,564...57,568,693
Ensembl chr15:51,159,220...51,159,349

G

small nucleolar RNA, H/ACA box 3A

increases expression

trovafloxacin results in increased expression of SNORA3 mRNA

NCBI chr 7:125,820,534...125,820,664
Ensembl chr 1:163,540,664...163,540,793

G

small nucleolar RNA, H/ACA box 47

increases expression

trovafloxacin results in increased expression of SNORA47 mRNA

NCBI chr 2:26,594,260...26,594,397
Ensembl chr 2:26,594,260...26,594,397

G

small nucleolar RNA, H/ACA box 52

increases expression

trovafloxacin results in increased expression of SNORA52 mRNA

NCBI chr 1:196,547,488...196,547,621
Ensembl chr 1:196,547,488...196,547,621

G

small nucleolar RNA, H/ACA box 5C

increases expression

trovafloxacin results in increased expression of SNORA5C mRNA

NCBI chr14:85,701,133...85,701,269
Ensembl chr14:81,487,218...81,487,354

G

small nucleolar RNA, H/ACA box 64

increases expression

trovafloxacin results in increased expression of SNORA64 mRNA

NCBI chr10:13,748,139...13,748,272
Ensembl chr10:13,748,139...13,748,272

G

small nucleolar RNA, H/ACA box 65

increases expression

trovafloxacin results in increased expression of SNORA65 mRNA

NCBI chr 3:16,265,801...16,265,930
Ensembl chr 3:16,265,801...16,265,930

G

small nucleolar RNA, H/ACA box 73b

increases expression

trovafloxacin results in increased expression of SNORA73B mRNA

NCBI chr 5:149,829,190...149,829,393
Ensembl chr 5:144,545,179...144,545,382

G

small nucleolar RNA, H/ACA box 81

increases expression

trovafloxacin results in increased expression of SNORA81 mRNA

NCBI chr10:28,278,802...28,278,949
Ensembl chr10:27,777,322...27,777,469

G

small nucleolar RNA, C/D box 104

increases expression

trovafloxacin results in increased expression of SNORD104 mRNA

NCBI chr10:91,935,074...91,935,143
Ensembl chr10:91,435,313...91,435,382

G

small nucleolar RNA, C/D box 14D

increases expression

trovafloxacin results in increased expression of SNORD14D mRNA

NCBI chr 8:41,186,057...41,186,142
Ensembl chr 8:41,186,057...41,186,142

G

small nucleolar RNA, C/D box 16

increases expression

trovafloxacin results in increased expression of SNORD16A mRNA

NCBI chr 8:64,673,195...64,673,293
Ensembl chr 8:64,673,195...64,673,293

G

small nucleolar RNA, C/D box 17

increases expression

trovafloxacin results in increased expression of SNORD17 mRNA

NCBI chr 3:131,636,460...131,636,698
Ensembl chr 3:131,636,460...131,636,698

G

small nucleolar RNA, C/D box 19

increases expression

trovafloxacin results in increased expression of SNORD19 mRNA

NCBI chr16:6,210,838...6,210,914
Ensembl chr16:6,210,838...6,210,914

G

small nucleolar RNA, C/D box 1C

increases expression

trovafloxacin results in increased expression of SNORD1C mRNA

NCBI chr10:102,404,626...102,404,701
Ensembl chr10:101,905,797...101,905,872

G

small nucleolar RNA, C/D box 2

increases expression

trovafloxacin results in increased expression of SNORD2 mRNA

NCBI chr11:77,769,475...77,769,543
Ensembl chr11:77,769,475...77,769,543

G

small nucleolar RNA, C/D box 22

increases expression

trovafloxacin results in increased expression of SNORD22 mRNA

NCBI chr11:22,544,203...22,544,327
Ensembl chr11:9,097,799...9,097,923

G

small nucleolar RNA, C/D box 42B

increases expression

trovafloxacin results in increased expression of SNORD42B mRNA

NCBI chr10:63,078,825...63,078,893
Ensembl chr10:63,078,825...63,078,893

G

small nucleolar RNA, C/D box 43

increases expression

trovafloxacin results in increased expression of SNORD43 mRNA

NCBI chr 7:113,507,486...113,507,549
Ensembl chr 7:111,627,136...111,627,199

G

small nucleolar RNA, C/D box 49A

increases expression

trovafloxacin results in increased expression of SNORD49A mRNA

NCBI chr10:47,297,488...47,297,559
Ensembl chr10:47,297,488...47,297,559

G

small nucleolar RNA, C/D box 4A

increases expression

trovafloxacin results in increased expression of SNORD4A mRNA

NCBI chr10:63,077,419...63,077,489
Ensembl chr10:63,077,419...63,077,489

G

small nucleolar RNA, C/D box 53

increases expression

trovafloxacin results in increased expression of SNORD53 mRNA

NCBI chr 6:23,861,377...23,861,454
Ensembl chr 6:23,861,377...23,861,454

G

small nucleolar RNA, C/D box 55

increases expression

trovafloxacin results in increased expression of SNORD55 mRNA

NCBI chr 5:130,632,614...130,632,692
Ensembl chr 5:130,632,614...130,632,692

G

small nucleolar RNA, C/D box 57

increases expression

trovafloxacin results in increased expression of SNORD57 mRNA

NCBI chr 3:117,480,517...117,480,588
Ensembl chr 3:117,480,517...117,480,588

G

small nucleolar RNA, C/D box 58B

increases expression

trovafloxacin results in increased expression of SNORD58B mRNA

NCBI chr18:68,581,864...68,581,929
Ensembl chr18:68,581,864...68,581,929

G

small nucleolar RNA, C/D box 69

increases expression

trovafloxacin results in increased expression of SNORD69 mRNA

NCBI chr16:6,208,922...6,209,001
Ensembl chr16:6,208,922...6,209,001

G

small nucleolar RNA, C/D box 72

increases expression

trovafloxacin results in increased expression of SNORD72 mRNA

NCBI chr 2:54,217,160...54,217,239
Ensembl chr 2:54,217,160...54,217,239

G

small nucleolar RNA, C/D box U73B

increases expression

trovafloxacin results in increased expression of SNORD73B mRNA

NCBI chr 2:171,527,196...171,527,269
Ensembl chr 2:171,527,196...171,527,269

G

small nucleolar RNA, C/D box 8

increases expression

trovafloxacin results in increased expression of SNORD8 mRNA

NCBI chr15:27,391,331...27,391,440
Ensembl chr15:24,917,836...24,917,945

G

small nucleolar RNA, C/D box 83B

increases expression

trovafloxacin results in increased expression of SNORD83B mRNA

NCBI chr 7:113,503,235...113,503,328
Ensembl chr 7:111,622,885...111,622,978

G

small nucleolar RNA, C/D box 89

increases expression

trovafloxacin results in increased expression of SNORD89 mRNA

NCBI chr 9:41,827,972...41,828,086
Ensembl chr 9:41,827,972...41,828,086

G

small nucleolar RNA, C/D box 99

increases expression

trovafloxacin results in increased expression of SNORD99 mRNA

NCBI chr 5:144,506,901...144,506,974
Ensembl chr 5:144,506,901...144,506,974

G

small nuclear ribonucleoprotein U11/U12 subunit 48

increases expression

trovafloxacin results in increased expression of SNRNP48 mRNA

NCBI chr17:26,801,818...26,821,605
Ensembl chr17:26,596,275...26,616,040

G

small nuclear ribonucleoprotein D3 polypeptide

increases expression

trovafloxacin results in increased expression of SNRPD3 mRNA

NCBI chr20:13,129,555...13,145,100
Ensembl chr20:13,130,119...13,145,978

G

sorting nexin 22

increases expression

trovafloxacin results in increased expression of SNX22 mRNA

NCBI chr 8:75,503,297...75,509,271
Ensembl chr 8:66,609,970...66,612,850

G

sorting nexin 25

decreases expression

trovafloxacin results in decreased expression of SNX25 mRNA

NCBI chr16:52,867,102...52,971,028
Ensembl chr16:46,125,804...46,238,440

G

sorting nexin 32

decreases expression

trovafloxacin results in decreased expression of SNX32 mRNA

NCBI chr 1:212,231,716...212,248,127
Ensembl chr 1:202,802,394...202,818,743

G

sorting nexin 4

multiple interactions

[trovafloxacin co-treated with TNF protein] results in decreased expression of SNX4 mRNA

NCBI chr11:80,965,965...81,023,234
Ensembl chr11:67,460,870...67,518,174

G

sterol O-acyltransferase 2

decreases expression

trovafloxacin results in decreased expression of SOAT2 mRNA

NCBI chr 7:135,160,424...135,173,521
Ensembl chr 7:133,281,818...133,294,915

G

suppressor of cytokine signaling 2

increases expression
multiple interactions

trovafloxacin results in increased expression of SOCS2 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS2 mRNA

PMID:18930950 PMID:24136188

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:30,008,578...30,043,548

G

suppressor of cytokine signaling 3

multiple interactions
increases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOCS3 mRNA
trovafloxacin results in increased expression of SOCS3 mRNA

PMID:18930950 PMID:35537566

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sorbin and SH3 domain containing 1

decreases expression

trovafloxacin results in decreased expression of SORBS1 mRNA

NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169

G

sorbin and SH3 domain containing 3

decreases expression

trovafloxacin results in decreased expression of SORBS3 mRNA

NCBI chr15:51,662,639...51,699,161
Ensembl chr15:45,253,379...45,284,758

G

sortilin related receptor 1

decreases expression

trovafloxacin results in decreased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513

G

Sp4 transcription factor

decreases expression

trovafloxacin results in decreased expression of SP4 mRNA

NCBI chr 6:145,330,416...145,395,750
Ensembl chr 6:139,192,147...139,252,126

G

sperm associated antigen 17

increases expression

trovafloxacin results in increased expression of SPAG17 mRNA

NCBI chr 2:189,952,649...190,199,623
Ensembl chr 2:187,264,009...187,510,501

G

sperm associated antigen 5

decreases expression

trovafloxacin results in decreased expression of SPAG5 mRNA

NCBI chr10:63,693,300...63,714,813
Ensembl chr10:63,198,768...63,216,745

G

spartin

decreases expression

trovafloxacin results in decreased expression of SPART mRNA

NCBI chr 2:141,442,770...141,469,388
Ensembl chr 2:139,292,355...139,319,248

G

spermatogenesis associated 24

decreases expression

trovafloxacin results in decreased expression of SPATA24 mRNA

NCBI chr18:27,523,133...27,531,375
Ensembl chr18:27,248,609...27,257,124

G

SPC24 component of NDC80 kinetochore complex

decreases expression

trovafloxacin results in decreased expression of SPC24 mRNA

NCBI chr 8:28,576,409...28,581,481
Ensembl chr 8:20,300,319...20,305,310

G

SPC25 component of NDC80 kinetochore complex

decreases expression

trovafloxacin results in decreased expression of SPC25 mRNA

NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959

G

spindle apparatus coiled-coil protein 1

decreases expression

trovafloxacin results in decreased expression of SPDL1 mRNA

NCBI chr10:19,773,456...19,798,341
Ensembl chr10:19,269,127...19,294,127

G

sperm flagellar 1

decreases expression

trovafloxacin results in decreased expression of SPEF1 mRNA

NCBI chr 3:138,843,679...138,849,762
Ensembl chr 3:118,390,575...118,394,531

G

sialophorin

decreases expression

trovafloxacin results in decreased expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628

G

sprouty-related, EVH1 domain containing 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SPRED2 mRNA

NCBI chr14:98,350,577...98,452,143
Ensembl chr14:94,148,837...94,249,162

G

sprouty RTK signaling antagonist 2

increases expression

trovafloxacin results in increased expression of SPRY2 mRNA

NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009

G

spectrin, beta, non-erythrocytic 4

increases expression

trovafloxacin results in increased expression of SPTBN4 mRNA

NCBI chr 1:91,778,379...91,865,970
Ensembl chr 1:82,650,751...82,737,228

G

serine palmitoyltransferase, small subunit A

increases expression

trovafloxacin results in increased expression of SPTSSA mRNA

NCBI chr 6:77,879,931...77,891,344
Ensembl chr 6:72,144,714...72,156,214

G

SRC proto-oncogene, non-receptor tyrosine kinase

increases expression

trovafloxacin results in increased expression of SRC mRNA

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 1

decreases expression

trovafloxacin results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

SLIT-ROBO Rho GTPase activating protein 3

increases expression

trovafloxacin results in increased expression of SRGAP3 mRNA

NCBI chr 4:147,391,082...147,626,407
Ensembl chr 4:145,840,078...146,070,575

G

spermidine synthase

decreases expression

trovafloxacin results in decreased expression of SRM mRNA

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:159,025,873...159,029,405

G

signal recognition particle 72

decreases expression

trovafloxacin results in decreased expression of SRP72 mRNA

NCBI chr14:31,522,424...31,549,978
Ensembl chr14:31,168,293...31,195,729

G

serine/arginine repetitive matrix 2

increases expression

trovafloxacin results in increased expression of SRRM2 mRNA

NCBI chr10:13,320,059...13,353,337
Ensembl chr10:12,815,471...12,848,751

G

serine and arginine rich splicing factor 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF1 mRNA

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 2

decreases expression
multiple interactions

trovafloxacin results in decreased expression of SRSF2 mRNA
[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF2 mRNA

PMID:18930950 PMID:24136188

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,052,314...102,055,338

G

serine and arginine rich splicing factor 3

decreases expression

trovafloxacin results in decreased expression of SRSF3 mRNA

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,091,910...7,101,078

G

serine and arginine rich splicing factor 4

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SRSF4 mRNA

NCBI chr 5:149,345,538...149,373,309
Ensembl chr 5:144,061,463...144,089,229

G

serine and arginine rich splicing factor 5

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SRSF5 mRNA

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:100,605,456...100,610,177

G

single stranded DNA binding protein 4

decreases expression

trovafloxacin results in decreased expression of SSBP4 mRNA

NCBI chr16:18,862,007...18,872,917
Ensembl chr16:18,828,054...18,838,947

G

slingshot protein phosphatase 2

decreases expression

trovafloxacin results in decreased expression of SSH2 mRNA

NCBI chr10:62,555,388...62,807,457
Ensembl chr10:62,057,044...62,306,563

G

SSX family member 2 interacting protein

decreases expression

trovafloxacin results in decreased expression of SSX2IP mRNA

NCBI chr 2:237,958,286...237,991,026
Ensembl chr 2:235,298,088...235,330,745

G

ST6 beta-galactoside alpha-2,6-sialyltransferase 1

decreases expression

trovafloxacin results in decreased expression of ST6GAL1 mRNA

NCBI chr11:91,031,481...91,158,111
Ensembl chr11:77,526,837...77,653,310

G

STAG2 cohesin complex component

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STAG2 mRNA

NCBI chr X:125,839,660...125,971,209
Ensembl chr X:120,974,857...121,105,677

G

StAR-related lipid transfer domain containing 4

increases expression

trovafloxacin results in increased expression of STARD4 mRNA

NCBI chr18:25,088,831...25,104,172
Ensembl chr18:24,817,107...24,830,024

G

StAR-related lipid transfer domain containing 5

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STARD5 mRNA
trovafloxacin results in decreased expression of STARD5 mRNA

PMID:18930950 PMID:35537566

NCBI chr 1:147,015,304...147,025,170
Ensembl chr 1:137,606,177...137,616,469

G

signal transducer and activator of transcription 3

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

starch binding domain 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of STBD1 mRNA

NCBI chr14:15,754,769...15,758,174
Ensembl chr14:15,469,582...15,477,443

G

stanniocalcin 2

decreases expression

trovafloxacin results in decreased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973

G

STIL, centriolar assembly protein

decreases expression

trovafloxacin results in decreased expression of STIL mRNA

NCBI chr 5:133,757,598...133,810,493
Ensembl chr 5:128,520,953...128,573,730

G

stress-induced phosphoprotein 1

decreases expression

trovafloxacin results in decreased expression of STIP1 mRNA

NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476

G

serine/threonine kinase-like domain containing 1

decreases expression

trovafloxacin results in decreased expression of STKLD1 mRNA

NCBI chr 3:30,659,659...30,678,650
Ensembl chr 3:10,261,828...10,280,566

G

stathmin 1

decreases expression

trovafloxacin results in decreased expression of STMN1 mRNA

PMID:24136188 PMID:35537566

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154

G

spermatid perinuclear RNA binding protein

decreases expression

trovafloxacin results in decreased expression of STRBP mRNA

NCBI chr 3:41,738,096...41,879,054
Ensembl chr 3:21,337,855...21,414,949

G

steroid sulfatase

increases expression

trovafloxacin results in increased expression of STS mRNA

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:42,225,372...42,233,402

G

syntaxin 1A

increases expression

trovafloxacin results in increased expression of STX1A mRNA

NCBI chr12:27,278,517...27,306,547
Ensembl chr12:21,641,969...21,669,930

G

syntaxin binding protein 5

decreases expression

trovafloxacin results in decreased expression of STXBP5 mRNA

NCBI chr 1:6,002,738...6,155,528
Ensembl chr 1:4,185,529...4,335,101

G

sulfatase 2

increases expression

trovafloxacin results in increased expression of SULF2 mRNA

NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:154,822,085...154,904,415

G

small ubiquitin-like modifier 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of SUMO2 mRNA

NCBI chr10:101,270,899...101,283,458
Ensembl chr10:100,686,797...100,784,513
Ensembl chr 5:100,686,797...100,784,513

G

Sad1 and UNC84 domain containing 2

decreases expression

trovafloxacin results in decreased expression of SUN2 mRNA

NCBI chr 7:113,155,766...113,172,950
Ensembl chr 7:111,275,380...111,292,553

G

SPT4 homolog, DSIF elongation factor subunit

increases expression

trovafloxacin results in increased expression of SUPT4A mRNA

NCBI chr10:73,036,560...73,042,821
Ensembl chr10:72,539,382...72,545,831

G

SURF1, cytochrome c oxidase assembly factor

decreases expression

trovafloxacin results in decreased expression of SURF1 mRNA

NCBI chr 3:30,639,868...30,642,759
Ensembl chr 3:10,241,837...10,263,315

G

SUV39H1 histone lysine methyltransferase

decreases expression

trovafloxacin results in decreased expression of SUV39H1 mRNA

NCBI chr X:17,093,059...17,105,942
Ensembl chr X:14,421,109...14,433,982

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

decreases expression

trovafloxacin results in decreased expression of SUV39H1 mRNA

NCBI chr X:146,828,818...146,831,485

G

supervillin

decreases expression

trovafloxacin results in decreased expression of SVIL mRNA

NCBI chr17:57,343,910...57,539,508
Ensembl chr17:52,648,502...52,793,404

G

synaptonemal complex protein 1

increases expression

trovafloxacin results in increased expression of SYCP1 mRNA

NCBI chr 2:192,985,164...193,145,234
Ensembl chr 2:190,296,954...190,456,737

G

synapsin III

decreases expression

trovafloxacin results in decreased expression of SYN3 mRNA

NCBI chr 7:19,244,032...19,701,571
Ensembl chr 7:17,376,372...17,808,790

G

synaptotagmin binding, cytoplasmic RNA interacting protein

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of SYNCRIP mRNA

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:89,402,866...89,435,515

G

spectrin repeat containing nuclear envelope protein 1

decreases expression

trovafloxacin results in decreased expression of SYNE1 mRNA

NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:41,512,030...41,983,322

G

spectrin repeat containing nuclear envelope protein 2

decreases expression

trovafloxacin results in decreased expression of SYNE2 mRNA

NCBI chr 6:100,272,729...100,586,364
Ensembl chr 6:94,537,088...94,848,064

G

synergin, gamma

increases expression

trovafloxacin results in increased expression of SYNRG mRNA

NCBI chr10:69,346,154...69,428,714
Ensembl chr10:68,849,642...68,931,250

G

synaptotagmin 7

decreases expression

trovafloxacin results in decreased expression of SYT7 mRNA

NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:207,031,592...207,089,026

G

TATA-box binding protein associated factor, RNA polymerase I subunit A

increases expression

trovafloxacin results in increased expression of TAF1A mRNA

NCBI chr13:97,543,772...97,579,742
Ensembl chr13:95,029,225...95,048,087

G

TATA-box binding protein associated factor, RNA polymerase 1 subunit C

increases expression

trovafloxacin results in increased expression of TAF1C mRNA

NCBI chr19:64,561,079...64,567,599
Ensembl chr19:47,652,452...47,658,971

G

TATA-box binding protein associated factor, RNA polymerase I subunit D

increases expression

trovafloxacin results in increased expression of TAF1D mRNA

NCBI chr 8:20,427,894...20,438,046
Ensembl chr 8:12,146,605...12,156,618

G

TATA-box binding protein associated factor 7

increases expression

trovafloxacin results in increased expression of TAF7 mRNA

NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,452,943...29,462,134

G

T-cell activation RhoGTPase activating protein

decreases expression

trovafloxacin results in decreased expression of TAGAP mRNA

NCBI chr 1:49,575,750...49,584,747
Ensembl chr 1:47,170,725...47,179,792

G

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

decreases expression

trovafloxacin results in decreased expression of TANC2 mRNA

NCBI chr10:91,052,860...91,373,291
Ensembl chr10:90,553,002...90,868,756

G

T cell-interacting, activating receptor on myeloid cells 1

decreases expression

trovafloxacin results in decreased expression of TARM1 mRNA

NCBI chr 1:74,582,103...74,600,203
Ensembl chr 1:65,671,902...65,679,626

G

threonyl-tRNA synthetase 3

decreases expression

trovafloxacin results in decreased expression of TARS3 mRNA

NCBI chr 1:128,623,678...128,675,978
Ensembl chr 1:119,213,213...119,265,488

G

tyrosine aminotransferase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TAT mRNA

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:37,947,112...37,958,031

G

TBC1 domain family, member 14

increases expression

trovafloxacin results in increased expression of TBC1D14 mRNA

NCBI chr14:78,397,345...78,496,863
Ensembl chr14:74,172,664...74,272,183

G

TBC1 domain family, member 31

decreases expression

trovafloxacin results in decreased expression of TBC1D31 mRNA

NCBI chr 7:91,316,905...91,396,434
Ensembl chr 7:89,426,780...89,506,894

G

TBC1 domain family, member 32

decreases expression

trovafloxacin results in decreased expression of TBC1D32 mRNA

NCBI chr20:35,902,281...36,133,161
Ensembl chr20:35,359,863...35,590,415

G

TBC1 domain family, member 8

increases expression

trovafloxacin results in increased expression of TBC1D8 mRNA

NCBI chr 9:49,147,109...49,257,140
Ensembl chr 9:41,651,395...41,761,409

G

transducin (beta)-like 3

decreases expression

trovafloxacin results in decreased expression of TBL3 mRNA

NCBI chr10:14,230,660...14,235,873
Ensembl chr10:13,726,129...13,731,372

G

T cell activation inhibitor, mitochondrial

increases expression

trovafloxacin results in increased expression of TCAIM mRNA

NCBI chr 8:122,414,827...122,446,105
Ensembl chr 8:122,414,818...122,446,092

G

transcription elongation factor A2

decreases expression

trovafloxacin results in decreased expression of TCEA2 mRNA

NCBI chr 3:189,173,756...189,181,633
Ensembl chr 3:168,796,331...168,804,116

G

transcription factor 19

decreases expression

trovafloxacin results in decreased expression of TCF19 mRNA

NCBI chr20:3,223,464...3,227,569
Ensembl chr20:3,218,693...3,223,271

G

T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3

decreases expression

trovafloxacin results in decreased expression of TCIRG1 mRNA

NCBI chr 1:210,556,270...210,568,021
Ensembl chr 1:201,127,034...201,138,742

G

treacle ribosome biogenesis factor 1

decreases expression

trovafloxacin results in decreased expression of TCOF1 mRNA

NCBI chr18:56,537,437...56,570,727
Ensembl chr18:54,267,026...54,300,324

G

tectonic family member 2

decreases expression

trovafloxacin results in decreased expression of TCTN2 mRNA

NCBI chr12:37,643,711...37,668,035
Ensembl chr12:31,822,733...32,007,069

G

tyrosyl-DNA phosphodiesterase 1

decreases expression

trovafloxacin results in decreased expression of TDP1 mRNA

NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:119,163,166...119,231,021

G

tectonin beta-propeller repeat containing 1

decreases expression

trovafloxacin results in decreased expression of TECPR1 mRNA

NCBI chr12:15,504,456...15,534,541
Ensembl chr12:10,391,696...10,419,611

G

terminal nucleotidyltransferase 2

decreases expression

trovafloxacin results in decreased expression of TENT2 mRNA

NCBI chr 2:26,115,150...26,167,465
Ensembl chr 2:24,380,225...24,432,099

G

terminal nucleotidyltransferase 5B

decreases expression

trovafloxacin results in decreased expression of FAM46B mRNA

NCBI chr 5:150,979,238...150,986,548
Ensembl chr 5:145,695,362...145,706,073
Ensembl chr11:145,695,362...145,706,073

G

telomerase reverse transcriptase

increases expression

trovafloxacin results in increased expression of TERT mRNA

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor B1, mitochondrial

decreases expression

trovafloxacin results in decreased expression of TFB1M mRNA

NCBI chr 1:46,520,510...46,567,004
Ensembl chr 1:44,119,166...44,161,709

G

transcription factor Dp-1

decreases expression

trovafloxacin results in decreased expression of TFDP1 mRNA

NCBI chr16:82,864,220...82,903,166
Ensembl chr16:76,162,043...76,200,817

G

transcription factor Dp-2

decreases expression

trovafloxacin results in decreased expression of TFDP2 mRNA

NCBI chr 8:105,640,018...105,781,026
Ensembl chr 8:96,760,504...96,896,682

G

trafficking from ER to golgi regulator

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TFG mRNA
trovafloxacin results in decreased expression of TFG mRNA

PMID:18930950 PMID:24136188

NCBI chr11:57,354,607...57,381,071
Ensembl chr11:43,885,661...43,911,976

G

transferrin receptor

increases expression

trovafloxacin results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257

G

TGFB-induced factor homeobox 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGIF1 mRNA

NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:110,720,921...110,757,802

G

transglutaminase 2

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TGM2 mRNA

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:146,772,687...146,801,981

G

thrombospondin 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THBS1 mRNA

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440

G

thyroid hormone receptor associated protein 3

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of THRAP3 mRNA

NCBI chr 5:143,729,821...143,772,105
Ensembl chr 5:138,445,295...138,487,477

G

thyroid hormone responsive

decreases expression

trovafloxacin results in decreased expression of THRSP mRNA

NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075

G

THUMPD3 antisense RNA 1

increases expression

trovafloxacin results in increased expression of GT(ROSA)26SOR mRNA

NCBI chr 4:146,210,520...146,217,026

G

TIR domain containing adaptor molecule 2

decreases expression

trovafloxacin results in decreased expression of TICAM2 mRNA

NCBI chr18:41,481,057...41,498,065
Ensembl chr18:39,294,453...39,311,462

G

TOPBP1-interacting checkpoint and replication regulator

decreases expression

trovafloxacin results in decreased expression of TICRR mRNA

NCBI chr 1:143,006,989...143,048,836
Ensembl chr 1:133,597,716...133,639,523

G

timeless circadian regulator

decreases expression

trovafloxacin results in decreased expression of TIMELESS mRNA

NCBI chr 7:1,239,388...1,263,344
Ensembl chr 7:654,822...678,738

G

TERF1 interacting nuclear factor 2

decreases expression

trovafloxacin results in decreased expression of TINF2 mRNA

NCBI chr15:33,140,611...33,146,930
Ensembl chr15:29,170,652...29,176,984

G

tight junction protein 3

decreases expression

trovafloxacin results in decreased expression of TJP3 mRNA

NCBI chr 7:9,078,757...9,097,003
Ensembl chr 7:8,432,811...8,446,279

G

thymidine kinase 1

decreases expression

trovafloxacin results in decreased expression of TK1 mRNA

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920

G

triokinase and FMN cyclase

decreases expression

trovafloxacin results in decreased expression of TKFC mRNA

NCBI chr 1:216,664,446...216,677,815
Ensembl chr 1:207,236,557...207,252,737

G

transketolase

decreases expression

trovafloxacin results in decreased expression of TKT mRNA

NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,723,762...5,748,698

G

TLE family member 1, transcriptional corepressor

increases expression

trovafloxacin results in increased expression of TLE1 mRNA

NCBI chr 5:90,898,182...90,982,118
Ensembl chr 5:85,851,827...85,934,774

G

talin 2

decreases expression

trovafloxacin results in decreased expression of TLN2 mRNA

NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:67,834,326...68,252,219

G

TM2 domain containing 3

increases expression

trovafloxacin results in increased expression of TM2D3 mRNA

NCBI chr 1:128,677,680...128,687,580
Ensembl chr 1:119,264,576...119,277,099

G

transmembrane 7 superfamily member 2

decreases expression

trovafloxacin results in decreased expression of TM7SF2 mRNA

NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:203,355,931...203,360,270

G

transmembrane 9 superfamily member 4

decreases expression

trovafloxacin results in decreased expression of TM9SF4 mRNA

NCBI chr 3:162,086,758...162,135,620
Ensembl chr 3:141,627,346...141,675,386

G

transmembrane channel-like 8

decreases expression

trovafloxacin results in decreased expression of TMC8 mRNA

NCBI chr10:103,498,505...103,509,496
Ensembl chr10:102,998,402...103,010,590

G

transmembrane and coiled-coil domains 4

decreases expression

trovafloxacin results in decreased expression of TMCO4 mRNA

NCBI chr 5:151,216,499...151,294,726
Ensembl chr 5:151,216,812...151,294,723

G

transmembrane and coiled-coil domains 5A

increases expression

trovafloxacin results in increased expression of TMCO5 mRNA

NCBI chr 3:124,187,005...124,200,308
Ensembl chr 3:103,732,945...103,746,249

G

transmembrane and coiled-coil domains 6

decreases expression

trovafloxacin results in decreased expression of TMCO6 mRNA

NCBI chr18:28,623,269...28,629,864
Ensembl chr18:28,349,248...28,355,843

G

transmembrane protein 106B

increases expression

trovafloxacin results in increased expression of TMEM106B mRNA

NCBI chr 4:42,294,074...42,313,426
Ensembl chr 4:41,327,994...41,345,619

G

transmembrane protein 107

decreases expression

trovafloxacin results in decreased expression of TMEM107 mRNA

NCBI chr10:54,268,218...54,273,520
Ensembl chr10:53,771,784...53,774,676

G

transmembrane protein 123

decreases expression

trovafloxacin results in decreased expression of TMEM123 mRNA

NCBI chr 8:13,206,907...13,237,069
Ensembl chr 8:4,922,098...4,952,224

G

transmembrane protein 128

increases expression

trovafloxacin results in increased expression of TMEM128 mRNA

NCBI chr14:76,751,848...76,761,576
Ensembl chr14:72,539,532...72,548,550

G

transmembrane protein 144

decreases expression

trovafloxacin results in decreased expression of TMEM144 mRNA

NCBI chr 2:167,258,788...167,291,701
Ensembl chr 2:164,961,247...164,992,368

G

transmembrane protein 158

decreases expression

trovafloxacin results in decreased expression of TMEM158 mRNA

NCBI chr 8:131,791,137...131,792,135
Ensembl chr 8:122,913,675...122,914,673

G

transmembrane protein 171

increases expression

trovafloxacin results in increased expression of TMEM171 mRNA

NCBI chr 2:31,769,486...31,779,358
Ensembl chr 2:30,035,278...30,045,049

G

transmembrane protein 191C

decreases expression

trovafloxacin results in decreased expression of TMEM191C mRNA

NCBI chr11:97,230,390...97,232,481
Ensembl chr11:83,725,185...83,730,172

G

transmembrane protein 209

decreases expression

trovafloxacin results in decreased expression of TMEM209 mRNA

NCBI chr 4:60,070,346...60,096,039
Ensembl chr 4:59,101,550...59,128,630

G

transmembrane protein 216

increases expression

trovafloxacin results in increased expression of TMEM216 mRNA

NCBI chr 1:216,621,365...216,627,497
Ensembl chr 1:207,196,454...207,201,754

G

transmembrane protein 221

decreases expression

trovafloxacin results in decreased expression of TMEM221 mRNA

NCBI chr16:18,296,036...18,305,077
Ensembl chr16:18,262,052...18,266,967

G

transmembrane protein 260

decreases expression

trovafloxacin results in decreased expression of TMEM260 mRNA

NCBI chr15:24,213,658...24,287,242
Ensembl chr15:21,734,151...21,806,801

G

transmembrane protein 267

decreases expression

trovafloxacin results in decreased expression of TMEM267 mRNA

NCBI chr 2:53,309,857...53,321,466
Ensembl chr 2:51,581,252...51,587,636

G

transmembrane protein 41a

decreases expression

trovafloxacin results in decreased expression of TMEM41A mRNA

NCBI chr11:92,588,497...92,595,105
Ensembl chr11:79,084,001...79,090,613

G

transmembrane protein 71

decreases expression

trovafloxacin results in decreased expression of TMEM71 mRNA

NCBI chr 7:100,166,038...100,212,234
Ensembl chr 7:98,276,975...98,315,858

G

transmembrane protein 74

decreases expression

trovafloxacin results in decreased expression of TMEM74 mRNA

NCBI chr 7:76,814,000...76,822,633
Ensembl chr 7:74,931,694...74,937,934

G

transmembrane protein 79

decreases expression

trovafloxacin results in decreased expression of TMEM79 mRNA

NCBI chr 2:176,096,092...176,100,996
Ensembl chr 2:173,798,267...173,803,046

G

transmembrane protein 94

decreases expression

trovafloxacin results in decreased expression of TMEM94 mRNA

NCBI chr10:101,490,496...101,525,983
Ensembl chr10:100,991,573...101,027,394

G

tropomodulin 4

increases expression

trovafloxacin results in increased expression of TMOD4 mRNA

NCBI chr 2:185,384,547...185,389,549
Ensembl chr 2:182,695,709...182,700,540

G

thymopoietin

decreases expression

trovafloxacin results in decreased expression of TMPO mRNA

PMID:24136188 PMID:35537566

NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:25,586,725...25,667,727

G

thioredoxin-related transmembrane protein 2

decreases expression

trovafloxacin results in decreased expression of TMX2 mRNA

NCBI chr 3:90,161,628...90,169,278
Ensembl chr 3:69,754,939...69,762,587

G

thioredoxin-related transmembrane protein 4

increases expression

trovafloxacin results in increased expression of TMX4 mRNA

NCBI chr 3:142,309,026...142,352,415
Ensembl chr 3:121,856,261...121,899,641

G

tumor necrosis factor

multiple interactions
decreases uptake
decreases expression
increases expression
increases response to substance
increases secretion

4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of ATR protein]; [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to trovafloxacin; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [trovafloxacin results in increased activity of CASP3 protein]; [TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein; [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form; [trovafloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in decreased expression of ATG4C mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of BIRC2 mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of SNX4 mRNA; [trovafloxacin co-treated with TNF protein] results in decreased expression of XIAP mRNA; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP3 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP8 protein; [trovafloxacin co-treated with TNF protein] results in increased activity of CASP9 protein; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG10 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG16L1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG2A mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ATG4A mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of BIRC3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of GABARAPL1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of ICAM1 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of MAP1LC3B mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 protein; [trovafloxacin co-treated with TNF protein] results in increased expression of ULK2 mRNA; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of and results in increased activity of ATR protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK1 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of MAPK3 protein; [trovafloxacin co-treated with TNF protein] results in increased phosphorylation of RPS6KB1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form]; Sirolimus inhibits the reaction [[trovafloxacin co-treated with TNF protein] results in increased phosphorylation of EIF4EBP1 protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG14 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of ATG5 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of GABARAPL2 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3A mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3B2 mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of MAP1LC3C mRNA]; TNF protein inhibits the reaction [trovafloxacin results in increased expression of RB1CC1 mRNA]; TNF protein promotes the reaction [trovafloxacin results in increased expression of ATG9B mRNA]; TNF protein promotes the reaction [trovafloxacin results in increased expression of H2AX protein modified form]; TNF protein promotes the reaction [trovafloxacin results in increased phosphorylation of AKT1 protein]; trovafloxacin affects the reaction [TNF protein affects the localization of RELA protein modified form]; trovafloxacin affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of ATG9B mRNA]; U 0126 inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased activity of CASP3 protein]
trovafloxacin results in decreased uptake of TNF protein
trovafloxacin results in decreased expression of TNF
trovafloxacin results in increased expression of TNF mRNA; trovafloxacin results in increased expression of TNF protein
trovafloxacin results in increased susceptibility to TNF protein
trovafloxacin results in increased secretion of TNF protein
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased expression of and results in increased stability of TNF mRNA]; 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine inhibits the reaction [trovafloxacin results in increased expression of TNF protein]; [Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of TNF mRNA; [Pentoxifylline results in decreased expression of TNF mRNA] results in decreased susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; [TNF protein co-treated with trovafloxacin] results in increased cleavage of CASP3 protein; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein; [trovafloxacin co-treated with TNF protein] results in decreased expression of NFKBIA protein; IFNG protein promotes the reaction [[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; pyrazolanthrone inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]; TNF protein affects the susceptibility to [lipopolysaccharide, E coli O55-B5 co-treated with trovafloxacin]; TNF protein results in increased susceptibility to [Lipopolysaccharides co-treated with trovafloxacin]; trovafloxacin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; trovafloxacin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CCL2 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL1 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of CXCL2 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IFNG protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL18 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL1B protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of IL6 protein]; trovafloxacin promotes the reaction [TNF protein results in increased expression of NFKBIA mRNA]; trovafloxacin promotes the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; trovafloxacin results in increased expression of and results in increased stability of TNF mRNA; U 0126 inhibits the reaction [trovafloxacin promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [trovafloxacin results in increased expression of TNF mRNA]
TNF protein results in increased susceptibility to trovafloxacin

PMID:17709330 PMID:18930950 PMID:19362101 PMID:19638433 PMID:24097668 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions
increases expression

[Lipopolysaccharides co-treated with trovafloxacin] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of TNFAIP3 mRNA; trovafloxacin promotes the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]
[trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA; [trovafloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 protein
trovafloxacin results in increased expression of TNFAIP3 mRNA
trovafloxacin results in increased expression of TNFAIP3 mRNA; trovafloxacin results in increased expression of TNFAIP3 protein

PMID:18930950 PMID:32035082 PMID:35537566

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8 like 1

decreases expression

trovafloxacin results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:988,594...1,002,254

G

TNF receptor superfamily member 11A

increases expression

trovafloxacin results in increased expression of TNFRSF11A mRNA

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 4

increases expression

trovafloxacin results in increased expression of TNFRSF4 mRNA

NCBI chr 5:171,889,134...171,891,824
Ensembl chr 5:166,606,909...166,609,599

G

TNF receptor superfamily member 9

decreases expression

trovafloxacin results in decreased expression of TNFRSF9 mRNA

NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:161,381,662...161,408,000

G

TNF superfamily member 13

increases expression

trovafloxacin results in increased expression of TNFSF13 mRNA

NCBI chr10:54,898,805...54,901,815
Ensembl chr10:54,400,065...54,403,042

G

TNF superfamily member 14

decreases expression

trovafloxacin results in decreased expression of TNFSF14 mRNA

NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,069,104...2,073,216

G

TNF superfamily member 18

decreases expression

trovafloxacin results in decreased expression of TNFSF18 mRNA

NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169

G

TNFAIP3 interacting protein 3

increases expression

trovafloxacin results in increased expression of TNIP3 mRNA

NCBI chr 4:96,197,019...96,237,357
Ensembl chr 4:94,811,097...94,907,605

G

tankyrase 1 binding protein 1

decreases expression

trovafloxacin results in decreased expression of TNKS1BP1 mRNA

NCBI chr 3:90,542,006...90,566,720
Ensembl chr 3:70,137,837...70,160,038

G

troponin C1, slow skeletal and cardiac type

increases expression

trovafloxacin results in increased expression of TNNC1 mRNA

NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,402,171...6,405,634

G

tensin 2

decreases expression

trovafloxacin results in decreased expression of TNS2 mRNA

NCBI chr 7:135,108,401...135,126,505
Ensembl chr 7:133,206,364...133,247,888

G

transducer of ERBB2, 2

increases expression

trovafloxacin results in increased expression of TOB2 mRNA

NCBI chr 7:115,242,843...115,251,563
Ensembl chr 7:113,361,148...113,372,688

G

translocase of outer mitochondrial membrane 70

decreases expression

trovafloxacin results in decreased expression of TOMM70A mRNA

NCBI chr11:56,847,837...56,886,302
Ensembl chr11:43,377,216...43,417,202

G

DNA topoisomerase II alpha

decreases activity
decreases expression

trovafloxacin results in decreased activity of TOP2A protein
trovafloxacin results in decreased expression of TOP2A mRNA

PMID:24817034 PMID:35537566

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II binding protein 1

decreases expression

trovafloxacin results in decreased expression of TOPBP1 mRNA

NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:103,887,865...103,931,674

G

torsin 1A interacting protein 2

increases expression

trovafloxacin results in increased expression of TOR1AIP2 mRNA

NCBI chr13:70,775,483...70,806,794
Ensembl chr13:68,230,009...68,256,536
Ensembl chr13:68,230,009...68,256,536

G

tumor protein p53 inducible nuclear protein 1

increases expression

trovafloxacin results in increased expression of TRP53INP1 mRNA

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968

G

triosephosphate isomerase 1

decreases expression

trovafloxacin results in decreased expression of TPI1 mRNA

NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:157,615,386...157,619,541

G

tropomyosin 3

decreases expression

trovafloxacin results in decreased expression of TPM3 mRNA

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013

G

tyrosylprotein sulfotransferase 1

increases expression

trovafloxacin results in increased expression of TPST1 mRNA

NCBI chr12:32,180,688...32,247,478
Ensembl chr12:26,544,536...26,605,704

G

TPX2, microtubule nucleation factor

decreases expression

trovafloxacin results in decreased expression of TPX2 mRNA

NCBI chr 3:161,778,709...161,820,941
Ensembl chr 3:141,318,455...141,360,468

G

TNF receptor-associated factor 1

increases expression

trovafloxacin results in increased expression of TRAF1 mRNA

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807

G

Tnf receptor-associated factor 2

increases expression

trovafloxacin results in increased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:8,341,951...8,366,538

G

TRAF3 interacting protein 3

decreases expression

trovafloxacin results in decreased expression of TRAF3IP3 mRNA

NCBI chr13:107,223,499...107,248,358
Ensembl chr13:104,694,805...104,719,673

G

TRAF type zinc finger domain containing 1

increases expression

trovafloxacin results in increased expression of TRAFD1 mRNA

NCBI chr12:40,826,251...40,840,169
Ensembl chr12:35,165,606...35,179,525

G

TRAF-interacting protein

decreases expression

trovafloxacin results in decreased expression of TRAIP mRNA

NCBI chr 8:117,520,476...117,540,253
Ensembl chr 8:108,641,852...108,661,638

G

trafficking kinesin protein 1

increases expression

trovafloxacin results in increased expression of TRAK1 mRNA

NCBI chr 8:129,861,967...130,016,870
Ensembl chr 8:120,984,431...121,139,367

G

TP53 regulated inhibitor of apoptosis 1

increases expression

trovafloxacin results in increased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:41,267,549...41,270,042

G

tribbles pseudokinase 3

decreases expression

trovafloxacin results in decreased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 11

increases expression

trovafloxacin results in increased expression of TRIM11 mRNA

NCBI chr10:44,255,019...44,270,711
Ensembl chr10:43,758,354...43,771,138

G

tripartite motif-containing 21

increases expression

trovafloxacin results in increased expression of TRIM21 mRNA

NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440

G

tripartite motif-containing 25

increases expression

trovafloxacin results in increased expression of TRIM25 mRNA

NCBI chr10:74,310,024...74,328,473
Ensembl chr10:73,812,818...73,831,257

G

tripartite motif-containing 26

increases expression

trovafloxacin results in increased expression of TRIM26 mRNA

NCBI chr20:1,711,564...1,736,389
Ensembl chr20:1,709,788...1,731,120

G

tripartite motif-containing 34

increases expression

trovafloxacin results in increased expression of TRIM34A mRNA

NCBI chr 1:168,119,043...168,130,544
Ensembl chr 1:158,707,172...158,718,674

G

tripartite motif-containing 37

decreases expression

trovafloxacin results in decreased expression of TRIM37 mRNA

NCBI chr10:72,440,672...72,572,831
Ensembl chr10:71,943,375...72,075,558

G

tripartite motif-containing 39

increases expression

trovafloxacin results in increased expression of TRIM39 mRNA

NCBI chr20:2,008,528...2,022,383
Ensembl chr20:1,983,533...2,020,117

G

tripartite motif-containing 45

decreases expression

trovafloxacin results in decreased expression of TRIM45 mRNA

NCBI chr 2:191,038,355...191,047,826
Ensembl chr 2:188,349,744...188,359,204

G

tripartite motif-containing 46

decreases expression

trovafloxacin results in decreased expression of TRIM46 mRNA

NCBI chr 2:176,939,253...176,952,285
Ensembl chr 2:174,641,496...174,654,141

G

tripartite motif-containing 47

decreases expression

trovafloxacin results in decreased expression of TRIM47 mRNA

NCBI chr10:101,836,465...101,840,936
Ensembl chr10:101,337,573...101,342,044

G

tripartite motif-containing 7

increases expression

trovafloxacin results in increased expression of TRIM7 mRNA

NCBI chr10:33,706,614...33,722,609
Ensembl chr10:33,205,491...33,221,468

G

thyroid hormone receptor interactor 13

decreases expression

trovafloxacin results in decreased expression of TRIP13 mRNA

NCBI chr 1:31,185,700...31,230,638
Ensembl chr 1:29,357,130...29,402,074

G

tRNA methyltransferase 2 homolog A

increases expression

trovafloxacin results in increased expression of TRMT2A mRNA

NCBI chr11:96,241,998...96,246,719
Ensembl chr11:82,737,689...82,742,336

G

tRNA methyltransferase 44

increases expression

trovafloxacin results in increased expression of TRMT44 mRNA

NCBI chr14:79,399,943...79,424,761
Ensembl chr14:75,182,029...75,200,147

G

tRNA mitochondrial 2-thiouridylase

decreases expression

trovafloxacin results in decreased expression of TRMU mRNA

NCBI chr 7:118,849,586...118,866,190
Ensembl chr 7:116,969,756...116,986,355

G

trophinin associated protein

decreases expression

trovafloxacin results in decreased expression of TROAP mRNA

NCBI chr 7:132,111,892...132,121,296
Ensembl chr 7:130,234,544...130,242,365

G

tRNA phosphotransferase 1

decreases expression

trovafloxacin results in decreased expression of TRPT1 mRNA

NCBI chr 1:213,615,503...213,620,502
Ensembl chr 1:204,186,295...204,191,294

G

TSC22 domain family, member 3

decreases expression

trovafloxacin results in decreased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:104,217,925...104,276,861

G

teashirt zinc finger homeobox 1

decreases expression

trovafloxacin results in decreased expression of TSHZ1 mRNA

NCBI chr18:79,651,256...79,727,662
Ensembl chr18:77,377,394...77,453,509

G

tsukushi, small leucine rich proteoglycan

increases expression

trovafloxacin results in increased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:152,656,693...152,672,588

G

tetraspanin 10

decreases expression

trovafloxacin results in decreased expression of TSPAN10 mRNA

NCBI chr10:106,213,672...106,219,951
Ensembl chr10:105,715,961...105,719,813

G

tetraspanin 13

decreases expression

trovafloxacin results in decreased expression of TSPAN13 mRNA

NCBI chr 6:58,466,051...58,492,804
Ensembl chr 6:52,738,758...52,765,547

G

TSPO associated protein 1

decreases expression

trovafloxacin results in decreased expression of TSPOAP1 mRNA

NCBI chr10:73,053,414...73,083,640
Ensembl chr10:72,560,980...72,586,412

G

TSPY-like 2

increases expression

trovafloxacin results in increased expression of TSPYL2 mRNA

NCBI chr X:24,918,851...24,924,462
Ensembl chr X:21,439,478...21,445,089

G

TSR1, ribosome maturation factor

increases expression

trovafloxacin results in increased expression of TSR1 mRNA

NCBI chr10:60,258,790...60,270,238
Ensembl chr10:59,760,409...59,771,864

G

testis-specific serine kinase 4

decreases expression

trovafloxacin results in decreased expression of TSSK4 mRNA

NCBI chr15:33,108,248...33,114,083
Ensembl chr15:29,141,792...29,144,128

G

thiosulfate sulfurtransferase

decreases expression

trovafloxacin results in decreased expression of TST mRNA

NCBI chr 7:111,828,557...111,836,980
Ensembl chr 7:109,948,062...109,957,216

G

thiosulfate sulfurtransferase like domain containing 2

increases expression

trovafloxacin results in increased expression of TSTD2 mRNA

NCBI chr 5:65,167,362...65,211,525
Ensembl chr 5:60,393,454...60,415,916

G

tetratricopeptide repeat domain 28

decreases expression

trovafloxacin results in decreased expression of TTC28 mRNA

NCBI chr12:51,002,816...51,443,461
Ensembl chr12:45,345,399...45,783,547

G

tetratricopeptide repeat domain 3

decreases expression

trovafloxacin results in decreased expression of TTC3 mRNA

NCBI chr11:47,158,766...47,258,612
Ensembl chr11:33,688,952...33,788,975

G

tetratricopeptide repeat domain 39A

decreases expression

trovafloxacin results in decreased expression of TTC39A mRNA

NCBI chr 5:129,379,560...129,441,779
Ensembl chr 5:124,151,760...124,204,973

G

tetratricopeptide repeat domain 39B

decreases expression

trovafloxacin results in decreased expression of TTC39B mRNA

NCBI chr 5:102,649,259...102,754,092
Ensembl chr 5:97,609,392...97,736,270

G

tetratricopeptide repeat domain 7A

decreases expression

trovafloxacin results in decreased expression of TTC7A mRNA
trovafloxacin results in decreased expression of TTC7 mRNA

PMID:24136188 PMID:35537566

NCBI chr 6:12,912,822...13,015,374
Ensembl chr 6:7,159,061...7,261,892

G

transcription termination factor 2

decreases expression

trovafloxacin results in decreased expression of TTF2 mRNA

NCBI chr 2:191,054,942...191,086,331
Ensembl chr 2:188,366,331...188,397,689

G

Ttk protein kinase

decreases expression

trovafloxacin results in decreased expression of TTK mRNA

NCBI chr 8:93,632,678...93,672,664
Ensembl chr 8:84,754,315...84,792,651

G

tubulin tyrosine ligase like 3

increases expression

trovafloxacin results in increased expression of TTLL3 mRNA

NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889

G

tubulin tyrosine ligase like 5

decreases expression

trovafloxacin results in decreased expression of TTLL5 mRNA

NCBI chr 6:111,214,048...111,431,892
Ensembl chr 6:105,483,191...105,700,934

G

tubulin, alpha 1C

decreases expression

trovafloxacin results in decreased expression of TUBA1C mRNA

NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr X:130,192,016...130,199,647

G

tubulin, alpha 4A

decreases expression

trovafloxacin results in decreased expression of TUBA4A mRNA

NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918

G

tubulin, beta 2A class IIa

decreases expression

trovafloxacin results in decreased expression of TUBB2A mRNA

NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,747,503...30,800,714

G

tubulin, beta 4B class IVb

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TUBB4B mRNA
trovafloxacin results in decreased expression of TUBB4B mRNA

PMID:18930950 PMID:24136188

NCBI chr 3:28,435,999...28,438,455
Ensembl chr 3:8,037,799...8,040,296

G

tubulin, beta 5 class I

decreases expression

trovafloxacin results in decreased expression of TUBB5 mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940

G

tubulin, epsilon 1

decreases expression

trovafloxacin results in decreased expression of TUBE1 mRNA

NCBI chr20:44,105,405...44,124,947
Ensembl chr20:42,552,437...42,570,314

G

tubulin, gamma 1

decreases expression

trovafloxacin results in decreased expression of TUBG1 mRNA

NCBI chr10:86,553,143...86,559,733
Ensembl chr10:86,052,743...86,059,433

G

tubulin gamma complex component 2

decreases expression

trovafloxacin results in decreased expression of TUBGCP2 mRNA

NCBI chr 1:204,220,725...204,247,460
Ensembl chr 1:194,792,142...194,817,619

G

taurine up-regulated 1

increases expression

trovafloxacin results in increased expression of TUG1 mRNA

NCBI chr14:82,743,501...82,750,534
Ensembl chr14:78,522,506...78,526,927

G

TUB like protein 2

increases expression

trovafloxacin results in increased expression of TULP2 mRNA

NCBI chr 1:105,098,884...105,136,243
Ensembl chr 1:95,962,496...96,000,628

G

taxilin gamma

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TXLNG mRNA

NCBI chr X:35,495,822...35,544,716
Ensembl chr X:31,864,111...31,912,926

G

thioredoxin domain containing 15

decreases expression

trovafloxacin results in decreased expression of TXNDC15 mRNA

NCBI chr17:8,903,248...8,915,714
Ensembl chr17:8,845,084...8,910,539
Ensembl chr 7:8,845,084...8,910,539

G

ubiquitin-conjugating enzyme E2C

decreases expression

trovafloxacin results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2G 2

increases expression

trovafloxacin results in increased expression of UBE2G2 mRNA

NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,742...11,005,447

G

ubiquitin-conjugating enzyme E2I

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of UBE2I mRNA

NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443

G

ubiquitin-conjugating enzyme E2T

decreases expression

trovafloxacin results in decreased expression of UBE2T mRNA

NCBI chr13:48,955,166...48,965,668
Ensembl chr13:46,403,375...46,414,835

G

ubiquitin protein ligase E3B

decreases expression

trovafloxacin results in decreased expression of UBE3B mRNA

NCBI chr12:47,844,368...47,890,702
Ensembl chr12:42,183,760...42,230,094

G

ubiquitin protein ligase E3D

decreases expression

trovafloxacin results in decreased expression of UBE3D mRNA

NCBI chr 8:96,125,609...96,293,122
Ensembl chr 8:87,245,589...87,413,057

G

ubiquilin 1

decreases expression

trovafloxacin results in decreased expression of UBQLN1 mRNA

NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,439,002...6,477,090

G

UBX domain protein 6

decreases expression

trovafloxacin results in decreased expression of UBXN6 mRNA

NCBI chr 9:988,051...993,221
Ensembl chr 9:900,884...906,124

G

uridine-cytidine kinase 1

increases expression

trovafloxacin results in increased expression of UCK1 mRNA

NCBI chr 3:35,936,328...35,942,213
Ensembl chr 3:15,538,591...15,544,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases expression

trovafloxacin results in decreased expression of UGT2B17 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986

G

ubiquitin-like with PHD and ring finger domains 1

decreases expression

trovafloxacin results in decreased expression of UHRF1 mRNA

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,134,909...1,154,631

G

unc-51 like autophagy activating kinase 1

increases expression

trovafloxacin results in increased expression of ULK1 mRNA

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

unc-51 like autophagy activating kinase 2

increases expression
decreases expression
multiple interactions

trovafloxacin results in increased expression of ULK2 mRNA
trovafloxacin results in decreased expression of ULK2 mRNA
[trovafloxacin co-treated with TNF protein] results in increased expression of ULK2 mRNA

PMID:33609687 PMID:35537566

NCBI chr10:46,951,038...47,029,844
Ensembl chr10:46,454,030...46,530,407

G

unc-51 like kinase 4

decreases expression

trovafloxacin results in decreased expression of ULK4 mRNA

NCBI chr 8:129,548,431...129,843,555
Ensembl chr 8:120,670,866...120,966,924

G

uridine monophosphate synthetase

decreases expression

trovafloxacin results in decreased expression of UMPS mRNA

NCBI chr11:80,311,269...80,321,678
Ensembl chr11:66,806,045...66,821,903

G

unc-119 lipid binding chaperone B

increases expression

trovafloxacin results in increased expression of UNC119B mRNA

NCBI chr12:47,139,492...47,152,115
Ensembl chr12:41,478,808...41,491,432

G

unc-5 netrin receptor B

decreases expression

trovafloxacin results in decreased expression of UNC5B mRNA

NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537

G

unk like zinc finger

increases expression

trovafloxacin results in increased expression of UNKL mRNA

NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,206,189...14,252,225

G

UPF1, RNA helicase and ATPase

increases expression

trovafloxacin results in increased expression of UPF1 mRNA

NCBI chr16:19,110,531...19,131,327
Ensembl chr16:19,076,322...19,096,568

G

uroplakin 1A

increases expression

trovafloxacin results in increased expression of UPK1A mRNA

NCBI chr 1:94,987,110...94,998,083
Ensembl chr 1:85,859,671...85,870,354

G

uridine phosphorylase 1

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of UPP1 mRNA

NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462

G

ubiquinol-cytochrome c reductase complex assembly factor 1

increases expression

trovafloxacin results in increased expression of UQCC1 mRNA

NCBI chr 3:164,813,398...164,905,892
Ensembl chr 3:144,353,287...144,445,711

G

ubiquitin related modifier 1

increases expression

trovafloxacin results in increased expression of URM1 mRNA

NCBI chr 3:33,489,974...33,514,942
Ensembl chr 3:13,092,200...13,117,642
Ensembl chr 3:13,092,200...13,117,642

G

ubiquitin specific peptidase 1

decreases expression

trovafloxacin results in decreased expression of USP1 mRNA

NCBI chr 5:118,703,056...118,714,426
Ensembl chr 5:113,587,564...113,598,932

G

ubiquitin specific peptidase 18

increases expression

trovafloxacin results in increased expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 2

decreases expression

trovafloxacin results in decreased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:44,411,607...44,438,331

G

ubiquitin specific peptidase 27, X-linked

increases expression

trovafloxacin results in increased expression of USP27X mRNA

NCBI chr X:17,795,506...17,798,741
Ensembl chr X:15,124,596...15,125,912

G

ubiquitin specific peptidase 39

decreases expression

trovafloxacin results in decreased expression of USP39 mRNA

NCBI chr 4:105,932,140...105,964,551
Ensembl chr 4:104,373,955...104,406,359

G

ubiquitin specific peptidase like 1

increases expression

trovafloxacin results in increased expression of USPL1 mRNA

NCBI chr12:10,859,764...10,886,761
Ensembl chr12:5,823,359...5,850,366

G

utrophin

decreases expression

trovafloxacin results in decreased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313

G

vasohibin 1

decreases expression

trovafloxacin results in decreased expression of VASH1 mRNA

NCBI chr 6:112,060,086...112,076,689
Ensembl chr 6:106,329,123...106,345,726

G

vascular endothelial growth factor A

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

increases expression

trovafloxacin results in increased expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

vacuolar protein sorting 13 homolog A

decreases expression

trovafloxacin results in decreased expression of VPS13A mRNA

NCBI chr 1:223,328,784...223,555,500
Ensembl chr 1:213,901,999...214,128,555

G

vacuolar protein sorting 13 homolog B

decreases expression

trovafloxacin results in decreased expression of VPS13B mRNA

NCBI chr 7:68,436,996...69,013,574
Ensembl chr 7:66,558,471...67,128,429

G

vacuolar protein sorting 13 homolog C

decreases expression

trovafloxacin results in decreased expression of VPS13C mRNA

NCBI chr 8:77,359,499...77,533,009
Ensembl chr 8:68,478,395...68,651,895

G

VPS16 core subunit of CORVET and HOPS complexes

decreases expression

trovafloxacin results in decreased expression of VPS16 mRNA

NCBI chr 3:138,075,649...138,097,154
Ensembl chr 3:117,622,542...117,646,441

G

V-set and immunoglobulin domain containing 8

increases expression

trovafloxacin results in increased expression of VSIG8 mRNA

NCBI chr13:87,555,533...87,563,720
Ensembl chr13:85,023,177...85,031,364

G

von Willebrand factor A domain containing 8

decreases expression

trovafloxacin results in decreased expression of VWA8 mRNA

NCBI chr15:60,661,764...60,985,971
Ensembl chr15:54,252,584...54,576,870

G

WW domain binding protein 1-like

increases expression

trovafloxacin results in increased expression of WBP1L mRNA

NCBI chr 1:255,413,701...255,470,026
Ensembl chr 1:245,472,296...245,528,627

G

WDFY family member 4

decreases expression

trovafloxacin results in decreased expression of WDFY4 mRNA

NCBI chr16:8,228,147...8,456,777
Ensembl chr16:8,221,719...8,450,491

G

WD repeat and HMG-box DNA binding protein 1

decreases expression

trovafloxacin results in decreased expression of WDHD1 mRNA

NCBI chr15:22,957,492...23,002,820
Ensembl chr15:20,489,291...20,523,096

G

WD repeat containing planar cell polarity effector

decreases expression

trovafloxacin results in decreased expression of WDPCP mRNA

NCBI chr14:99,847,463...100,178,392
Ensembl chr14:95,646,038...95,977,113

G

WD repeat domain 11

decreases expression

trovafloxacin results in decreased expression of WDR11 mRNA

NCBI chr 1:193,595,606...193,641,149
Ensembl chr 1:184,165,571...184,210,846

G

WD repeat domain 45B

increases expression

trovafloxacin results in increased expression of WDR45B mRNA

NCBI chr10:107,097,655...107,127,839
Ensembl chr10:106,599,364...106,629,441

G

WD repeat domain 62

decreases expression

trovafloxacin results in decreased expression of WDR62 mRNA

NCBI chr 1:94,618,992...94,658,097
Ensembl chr 1:85,491,533...85,530,637

G

WD repeat domain 76

decreases expression

trovafloxacin results in decreased expression of WDR76 mRNA

NCBI chr 3:128,910,500...128,945,241
Ensembl chr 3:108,456,815...108,490,840

G

WD repeat domain 86

increases expression

trovafloxacin results in increased expression of WDR86 mRNA

NCBI chr 4:11,315,826...11,335,932
Ensembl chr 4:10,424,008...10,441,465

G

WD repeat domain 90

decreases expression

trovafloxacin results in decreased expression of WDR90 mRNA

NCBI chr10:15,369,184...15,385,797
Ensembl chr10:14,864,670...14,881,292

G

WEE1 G2 checkpoint kinase

decreases expression

trovafloxacin results in decreased expression of WEE1 mRNA

NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:164,174,779...164,197,688

G

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1

increases expression

trovafloxacin results in increased expression of WFIKKN1 mRNA

NCBI chr10:15,400,953...15,403,280
Ensembl chr10:14,896,378...14,899,863

G

WD repeat domain, phosphoinositide interacting 1

decreases expression

trovafloxacin results in decreased expression of WIPI1 mRNA

NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846

G

Wnt family member 2B

decreases expression

trovafloxacin results in decreased expression of WNT2B mRNA

NCBI chr 2:195,142,573...195,156,945
Ensembl chr 2:192,453,824...192,470,308

G

WRN RecQ like helicase

decreases expression

trovafloxacin results in decreased expression of WRN mRNA

NCBI chr16:65,466,552...65,602,951
Ensembl chr16:58,763,504...58,895,450

G

XIAP associated factor 1

increases expression

trovafloxacin results in increased expression of XAF1 mRNA

NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770

G

X-box binding protein 1

increases expression

trovafloxacin results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

G

xanthine dehydrogenase

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of XDH mRNA

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of XIAP mRNA
[trovafloxacin co-treated with TNF protein] results in decreased expression of XIAP mRNA
trovafloxacin results in decreased expression of XIAP mRNA

PMID:18930950 PMID:32035082

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

XK related 5

decreases expression

trovafloxacin results in decreased expression of XKR5 mRNA

NCBI chr16:77,577,387...77,595,377
Ensembl chr16:70,875,093...70,892,967

G

X-prolyl aminopeptidase 2

decreases expression

trovafloxacin results in decreased expression of XPNPEP2 mRNA

NCBI chr X:132,165,696...132,194,937
Ensembl chr X:127,287,979...127,317,223

G

exportin 1

decreases expression

trovafloxacin results in decreased expression of XPO1 mRNA

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:97,233,270...97,275,498

G

exportin for tRNA

decreases expression

trovafloxacin results in decreased expression of XPOT mRNA

NCBI chr 7:58,997,025...59,037,506
Ensembl chr 7:57,111,536...57,152,099

G

xylosyltransferase 2

increases expression

trovafloxacin results in increased expression of XYLT2 mRNA

NCBI chr10:80,102,776...80,116,346
Ensembl chr10:79,606,007...79,619,391

G

tyrosyl-tRNA synthetase 1

decreases expression

trovafloxacin results in decreased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:141,535,759...141,563,833

G

YdjC chitooligosaccharide deacetylase homolog

decreases expression

trovafloxacin results in decreased expression of YDJC mRNA

NCBI chr11:97,338,529...97,348,909
Ensembl chr11:83,841,306...83,846,336

G

YKT6 v-SNARE homolog

increases expression

trovafloxacin results in increased expression of YKT6 mRNA

NCBI chr14:85,041,393...85,057,347
Ensembl chr14:80,832,187...80,843,385

G

yippee-like 3

increases expression

trovafloxacin results in increased expression of YPEL3 mRNA

NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:181,384,357...181,387,705

G

yippee-like 5

increases expression

trovafloxacin results in increased expression of YPEL5 mRNA

NCBI chr 6:28,408,079...28,423,536
Ensembl chr 6:22,656,285...22,671,691

G

YY2 transcription factor

increases expression

trovafloxacin results in increased expression of YY2 mRNA

NCBI chr X:41,253,481...41,257,103
Ensembl chr X:37,410,811...37,464,430

G

zonadhesin

decreases expression

trovafloxacin results in decreased expression of ZAN mRNA

NCBI chr12:24,851,798...24,963,837
Ensembl chr12:19,215,102...19,271,240

G

zinc finger BED-type containing 5

increases expression

trovafloxacin results in increased expression of ZBED5 mRNA

NCBI chr12:32,443,687...32,449,817
Ensembl chr12:26,807,600...26,813,664

G

Z-DNA binding protein 1

increases expression

trovafloxacin results in increased expression of ZBP1 mRNA

NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870

G

zinc finger and BTB domain containing 48

increases expression

trovafloxacin results in increased expression of ZBTB48 mRNA

NCBI chr 5:167,807,965...167,816,332
Ensembl chr 5:162,525,235...162,533,585

G

zinc finger and BTB domain containing 49

increases expression

trovafloxacin results in increased expression of ZBTB49 mRNA

NCBI chr14:76,802,988...76,835,573
Ensembl chr14:72,590,708...72,612,404

G

zinc finger, C2HC-type containing 1C

increases expression

trovafloxacin results in increased expression of ZC2HC1C mRNA

NCBI chr 6:104,932,631...104,941,555
Ensembl chr 6:104,932,631...104,941,554

G

zinc finger CCCH type containing 12C

increases expression

trovafloxacin results in increased expression of ZC3H12C mRNA

NCBI chr 8:61,340,446...61,404,932
Ensembl chr 8:52,448,320...52,504,315

G

zinc finger CCCH type containing 6

decreases expression

trovafloxacin results in decreased expression of ZC3H6 mRNA

NCBI chr 3:136,656,116...136,717,560
Ensembl chr 3:116,204,197...116,253,282

G

zinc finger CCHC-type containing 24

decreases expression

trovafloxacin results in decreased expression of ZCCHC24 mRNA

NCBI chr16:1,281,350...1,333,278
Ensembl chr16:1,274,548...1,326,696

G

zinc finger CW-type and PWWP domain containing 1

decreases expression

trovafloxacin results in decreased expression of ZCWPW1 mRNA

NCBI chr12:24,517,428...24,547,942
Ensembl chr12:18,880,633...18,910,711

G

zinc finger AN1-type containing 2A

increases expression

trovafloxacin results in increased expression of ZFAND2A mRNA

NCBI chr12:20,275,435...20,286,513
Ensembl chr12:15,161,639...15,172,677

G

zinc finger AN1-type containing 4

decreases expression

trovafloxacin results in decreased expression of ZFAND4 mRNA

NCBI chr 4:149,327,339...149,399,495
Ensembl chr 4:149,327,412...149,399,487

G

zinc finger AN1-type containing 5

multiple interactions

[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of ZFAND5 mRNA

NCBI chr 1:218,765,735...218,780,391
Ensembl chr 1:218,766,614...218,775,843

G

zinc finger protein 142

increases expression

trovafloxacin results in increased expression of ZFP142 mRNA

NCBI chr 9:83,591,318...83,613,896
Ensembl chr 9:76,142,227...76,164,856

G

zinc finger protein 157

increases expression

trovafloxacin results in increased expression of ZFP157 mRNA

NCBI chr12:21,356,253...21,393,006
Ensembl chr12:16,248,230...16,270,698

G

zinc finger protein 2

increases expression

trovafloxacin results in increased expression of ZFP2 mRNA

NCBI chr10:35,701,303...35,729,861
Ensembl chr10:35,207,260...35,228,853

G

zinc finger protein 263

increases expression

trovafloxacin results in increased expression of ZFP263 mRNA

NCBI chr10:12,270,785...12,280,982
Ensembl chr10:11,764,427...11,771,235

G

zinc finger protein 275

increases expression

trovafloxacin results in increased expression of ZFP275 mRNA

NCBI chr X:156,208,873...156,225,732
Ensembl chr X:151,057,573...151,074,276

G

zinc finger protein 334

increases expression

trovafloxacin results in increased expression of ZFP334 mRNA

NCBI chr 3:174,531,835...174,544,374
Ensembl chr 3:154,113,561...154,125,057

G

zinc finger protein 346

decreases expression

trovafloxacin results in decreased expression of ZFP346 mRNA

NCBI chr17:9,498,933...9,528,824
Ensembl chr17:9,493,803...9,523,635

G

zinc finger protein 36

increases expression

trovafloxacin results in increased expression of ZFP36 mRNA

NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 420

decreases expression

trovafloxacin results in decreased expression of ZFP420 mRNA

NCBI chr 1:94,259,715...94,271,102
Ensembl chr 1:85,132,520...85,143,679

G

zinc finger protein 422

increases expression

trovafloxacin results in increased expression of ZFP422 mRNA

NCBI chr 4:151,558,254...151,565,730
Ensembl chr 4:149,885,600...149,893,257

G

zinc finger protein 449

increases expression

trovafloxacin results in increased expression of ZFP449 mRNA

NCBI chr X:139,127,425...139,147,490
Ensembl chr X:134,122,636...134,140,924

G

zinc finger protein 457

decreases expression

trovafloxacin results in decreased expression of ZFP457 mRNA

NCBI chr 2:86,333,770...86,350,883
Ensembl chr 2:84,608,705...84,684,942

G

zinc finger protein 462

increases expression

trovafloxacin results in increased expression of ZFP462 mRNA

NCBI chr 5:74,465,383...74,606,020
Ensembl chr 5:69,670,328...69,810,327

G

zinc finger protein 469

increases expression

trovafloxacin results in increased expression of ZFP469 mRNA

NCBI chr19:67,190,901...67,232,569

G

zinc finger protein 473

decreases expression

trovafloxacin results in decreased expression of ZFP473 mRNA

NCBI chr 1:95,222,683...95,243,328
Ensembl chr 1:95,223,433...95,243,325

G

zinc finger protein 513

increases expression

trovafloxacin results in increased expression of ZFP513 mRNA

NCBI chr 6:30,894,153...30,897,414
Ensembl chr 6:25,174,178...25,177,439

G

zinc finger protein 551

increases expression

trovafloxacin results in increased expression of ZFP551 mRNA

NCBI chr 1:81,615,977...81,626,233
Ensembl chr 1:72,540,108...72,554,071

G

zinc finger protein 574

increases expression

trovafloxacin results in increased expression of ZFP574 mRNA

NCBI chr 1:89,798,412...89,805,490
Ensembl chr 1:80,664,259...80,679,427

G

zinc finger protein 579

increases expression

trovafloxacin results in increased expression of ZFP579 mRNA

NCBI chr 1:77,876,367...77,879,591
Ensembl chr 1:68,847,500...68,850,751

G

zinc finger protein 58

increases expression

trovafloxacin results in increased expression of ZFP58 mRNA

NCBI chr 1:36,848,858...36,861,605
Ensembl chr 1:35,002,321...35,033,216

G

zinc finger protein 580

decreases expression

trovafloxacin results in decreased expression of ZFP580 mRNA

NCBI chr 1:77,815,959...77,818,127
Ensembl chr 1:68,787,118...68,789,286

G

zinc finger protein 599

increases expression

trovafloxacin results in increased expression of ZFP599 mRNA

NCBI chr 8:29,032,266...29,048,658
Ensembl chr 8:20,757,584...20,772,663

G

zinc finger protein 619

increases expression

trovafloxacin results in increased expression of ZFP619 mRNA

NCBI chr 1:100,284,802...100,304,443
Ensembl chr 1:91,148,121...91,166,403

G

zinc finger protein 629

increases expression

trovafloxacin results in increased expression of ZFP629 mRNA

NCBI chr 1:191,648,753...191,689,082
Ensembl chr 1:182,210,935...182,230,016

G

zinc finger protein 748

increases expression

trovafloxacin results in increased expression of ZFP748 mRNA

NCBI chr 1:35,075,408...35,091,416
Ensembl chr 1:35,074,172...35,091,389

G

zinc finger protein 768

increases expression

trovafloxacin results in increased expression of ZFP768 mRNA

NCBI chr 1:191,396,807...191,401,880
Ensembl chr 1:181,966,316...181,969,147

G

zinc finger protein 770

increases expression

trovafloxacin results in increased expression of ZFP770 mRNA

NCBI chr 3:100,963,430...100,971,663
Ensembl chr 3:100,963,427...100,971,684

G

zinc finger protein 791

increases expression

trovafloxacin results in increased expression of ZFP791 mRNA

NCBI chr19:39,921,848...39,942,507
Ensembl chr19:23,018,918...23,033,504

G

zinc finger protein 799

increases expression

trovafloxacin results in increased expression of ZFP799 mRNA

NCBI chr 7:12,548,586...12,561,317
Ensembl chr 7:11,898,149...11,910,798

G

zinc finger protein 84

increases expression

trovafloxacin results in increased expression of ZFP84 mRNA

NCBI chr 1:94,114,782...94,144,057
Ensembl chr 1:85,004,920...85,015,478
Ensembl chr 1:85,004,920...85,015,478

G

zinc finger protein 870

increases expression

trovafloxacin results in increased expression of ZFP870 mRNA

NCBI chr 7:12,640,653...12,654,320
Ensembl chr 7:11,990,148...12,003,813

G

zinc finger protein 955B

increases expression

trovafloxacin results in increased expression of ZFP955B mRNA

NCBI chr 7:13,260,517...13,275,939
Ensembl chr 7:12,610,196...12,622,587

G

zinc finger translocation associated

increases expression

trovafloxacin results in increased expression of ZFTA mRNA

NCBI chr 1:204,604,557...204,612,688
Ensembl chr 1:204,604,103...204,612,688

G

zinc finger, GATA-like protein 1

increases expression

trovafloxacin results in increased expression of ZGLP1 mRNA

NCBI chr 8:27,876,046...27,880,953
Ensembl chr 8:19,599,998...19,604,547

G

zinc finger, matrin type 3

increases expression

trovafloxacin results in increased expression of ZMAT3 mRNA

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger protein 408

increases expression

trovafloxacin results in increased expression of ZFP408 mRNA

NCBI chr 3:98,071,210...98,077,075
Ensembl chr 3:77,616,808...77,621,055

G

zinc finger protein 780B

increases expression

trovafloxacin results in increased expression of ZFP780B mRNA

NCBI chr 1:92,136,761...92,159,076
Ensembl chr 1:83,009,189...83,082,107

G

zinc finger, NFX1-type containing 1

increases expression

trovafloxacin results in increased expression of ZNFX1 mRNA

NCBI chr 3:176,183,111...176,210,812
Ensembl chr 3:155,764,980...155,821,242

G

zinc ribbon domain containing 2

increases expression

trovafloxacin results in increased expression of ZNRD2 mRNA

NCBI chr 1:212,447,010...212,448,793
Ensembl chr 1:203,017,682...203,019,465

G

zinc finger and SCAN domain containing 25

increases expression

trovafloxacin results in increased expression of ZSCAN25 mRNA

NCBI chr12:14,441,458...14,451,919
Ensembl chr12:9,326,404...9,338,221

G

zinc finger and SCAN domain containing 30

increases expression

trovafloxacin results in increased expression of ZSCAN30 mRNA

NCBI chr18:15,524,313...15,540,983
Ensembl chr18:15,244,379...15,264,632

G

zwilch kinetochore protein

decreases expression

trovafloxacin results in decreased expression of ZWILCH mRNA

NCBI chr 8:73,532,968...73,566,214
Ensembl chr 8:64,637,672...64,675,916

G

zinc finger, X-linked, duplicated B

increases expression

trovafloxacin results in increased expression of ZXDB mRNA

NCBI chr  X:63,710,381...63,716,353
Ensembl chr  X:59,701,178...59,703,871
Ensembl chr  X:59,701,178...59,703,871

G

ZXD family zinc finger C

increases expression

trovafloxacin results in increased expression of ZXDA mRNA

NCBI chr 4:124,439,560...124,471,694
Ensembl chr 4:122,882,336...122,916,496

G

zyg-11 family member A, cell cycle regulator

decreases expression

trovafloxacin results in decreased expression of ZYG11A mRNA

NCBI chr 5:122,935,439...122,973,766
Ensembl chr 5:122,937,136...122,973,649

vosaroxin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580

G

caspase 3

increases activity

vosaroxin results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency affects the localization of HIF1A protein]; vosaroxin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein]]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

isocitrate dehydrogenase (NADP(+)) 2

increases activity
multiple interactions

vosaroxin results in increased activity of IDH2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025

G

sirtuin 2

multiple interactions

SIRT2 protein affects the reaction [vosaroxin results in increased activity of IDH2 protein]; SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975

G

sirtuin 3

multiple interactions

SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:195,942,073...195,964,808

G

superoxide dismutase 2

increases activity
multiple interactions

vosaroxin results in increased activity of SOD2 protein
SIRT2 protein affects the reaction [vosaroxin results in increased activity of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19904
chemical entity	19902
molecular entity	19901
mancude ring	11345
organic mancude parent	11345
mancude organic heterocyclic parent	11345
mancude organic heterobicyclic parent	8378
naphthyridine	2258
1,8-naphthyridine	1914
1,8-naphthyridine derivative +	1914
Path 2
Term	Annotations
CHEBI ontology	19904
subatomic particle	19902
composite particle	19902
hadron	19902
baryon	19902
nucleon	19902
atomic nucleus	19902
atom	19902
main group element atom	19841
p-block element atom	19841
carbon group element atom	19779
carbon atom	19776
organic molecular entity	19776
organic molecule	19730
organic cyclic compound	19522
organic heterocyclic compound	18896
organic heteropolycyclic compound	18320
organic heterobicyclic compound	17261
mancude organic heterobicyclic parent	8378
naphthyridine	2258
1,8-naphthyridine	1914
1,8-naphthyridine derivative +	1914

paths to the root