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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorthalidone
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Accession:CHEBI:3654 term browser browse the term
Definition:An isoindole that has formula C14H11ClN2O4S.
Synonyms:related_synonym: 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline;   1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline;   2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide;   2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide;   3-(4'-chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine;   3-hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine;   Chlortalidone;   Formula=C14H11ClN2O4S;   InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21);   InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(ccc1Cl)C1(O)NC(=O)c2ccccc12;   chlorphthalidolone;   phthalamodine;   phthalamudine
 xref: Beilstein:312295;   CAS:77-36-1;   DrugBank:DB00310;   Drug_Central:625;   KEGG:D00272;   LINCS:LSM-1417
 xref_mesh: MESH:D002752
 xref: Wikipedia:Chlorthalidone


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chlorthalidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgfr3 fibroblast growth factor receptor 3 decreases expression EXP Chlorthalidone results in decreased expression of FGFR3 mRNA CTD PMID:20625077 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:81,211,800...81,227,209 		JBrowse link
G Nrp2 neuropilin 2 decreases expression EXP Chlorthalidone results in decreased expression of NRP2 mRNA CTD PMID:20625077 NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871 		JBrowse link
G Ren renin increases expression
increases activity 		ISO Chlorthalidone results in increased expression of REN protein modified form
Chlorthalidone results in increased activity of REN protein 		CTD PMID:796642 PMID:1116335 PMID:3319646 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Chlorthalidone results in decreased expression of TGFB3 mRNA CTD PMID:20625077 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression
increases expression 		EXP Chlorthalidone results in decreased expression of VEGFC mRNA; Chlorthalidone results in decreased expression of VEGFC protein
Chlorthalidone results in increased expression of VEGFC protein 		CTD PMID:20625077 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      atom 20860
        nonmetal atom 20766
          sulfur atom 18048
            sulfur molecular entity 18048
              organosulfur compound 17763
                sulfonamide 5379
                  chlorthalidone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      benzopyrrole 9850
                                        isoindoles 1158
                                          chlorthalidone 5
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