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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorprothixene
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Accession:CHEBI:3651 term browser browse the term
Definition:A thioxanthene that has formula C18H18ClNS.
Synonyms:exact_synonym: 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
 related_synonym: Alpha-Chlorprothixene;   Chlorprothixen;   Chlorprothixine;   Chlorprotixen;   Chlorprotixene;   Chlorprotixine;   Chlothixen;   Formula=C18H18ClNS;   InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3;   InChIKey=WSPOMRSOLSGNFJ-UHFFFAOYSA-N;   SMILES=[H]C(CCN(C)C)=C1c2ccccc2Sc2ccc(Cl)cc12;   chlorprothixenum;   clorprotixeno
 xref: Beilstein:89898;   DrugBank:DB01239;   HMDB:HMDB0015369;   KEGG:C07953;   KEGG:D00790;   LINCS:LSM-3310
 xref_mesh: MESH:D002749
 xref: Patent:GB829763;   Patent:US3046283
 cyclic_relationship: is_conjugate_base_of CHEBI:180503


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(Z)-chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      biological role 20803
        pharmacological role 19889
          analgesic 14882
            non-narcotic analgesic 14032
              chlorprothixene 3
                (E)-chlorprothixene 0
                (Z)-chlorprothixene 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              pnictogen hydride 18558
                                nitrogen hydride 18469
                                  azane 18229
                                    ammonia 18228
                                      organic amino compound 18228
                                        tertiary amino compound 10243
                                          chlorprothixene 3
                                            (E)-chlorprothixene 0
                                            (Z)-chlorprothixene 3
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