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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saturated organic heterocyclic parent
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Accession:CHEBI:36388 term browser browse the term
Synonyms:related_synonym: saturated heterocyclic parent hydride;   saturated heterocyclic parent hydrides;   saturated organic heterocyclic parents


show annotations for term's descendants           Sort by:
1,4,7-triazonane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases expression ISO 1,4,7-triazacyclononane results in decreased expression of CAT protein CTD PMID:32869927 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO 1,4,7-triazacyclononane results in increased expression of GPX1 protein CTD PMID:32869927 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO 1,4,7-triazacyclononane results in increased expression of NFE2L2 protein CTD PMID:32869927 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
1,4-dioxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aaas aladin WD repeat nucleoporin increases expression ISO 1,4-dioxane results in increased expression of AAAS mRNA CTD PMID:33693819 NCBI chr 7:135,342,901...135,362,545
Ensembl chr 7:135,342,901...135,362,545 		JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 1,4-dioxane results in increased expression of AOX1 mRNA CTD PMID:33693819 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression ISO 1,4-dioxane results in decreased expression of ATP6V0D2 mRNA CTD PMID:33693819 NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245 		JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 increases expression ISO 1,4-dioxane results in increased expression of ATP8B5 mRNA CTD PMID:33693819 NCBI chr 5:62,302,213...62,415,843
Ensembl chr 5:62,302,275...62,415,834 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO 1,4-dioxane results in increased expression of BTG2 mRNA CTD PMID:33693819 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO 1,4-dioxane results in increased expression of CCNG1 mRNA CTD PMID:33693819 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cpq carboxypeptidase Q decreases expression ISO 1,4-dioxane results in decreased expression of CPQ mRNA CTD PMID:33693819 NCBI chr 7:66,148,973...66,719,189
Ensembl chr 7:66,149,377...66,716,137 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:15490126 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP 1,4-dioxane results in increased expression of and results in increased activity of CYP2B2 protein CTD PMID:15490126 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
affects response to substance
affects metabolic processing
increases expression
increases activity 		EXP
ISO 		1,4-dioxane results in increased expression of and results in increased activity of CYP2E1 protein
CYP2E1 protein affects the susceptibility to 1,4-dioxane
CYP2E1 protein affects the metabolism of 1,4-dioxane
[CYP2E1 protein affects the metabolism of 1,4-dioxane] which affects the abundance of beta-hydroxyethoxyacetic acid
1,4-dioxane results in increased expression of CYP2E1 mRNA
1,4-dioxane results in increased activity of CYP2E1 protein 		CTD PMID:15490126 PMID:39192018 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 decreases expression ISO 1,4-dioxane results in decreased expression of CYP2G1 mRNA CTD PMID:33693819 NCBI chr 1:91,273,309...91,284,499
Ensembl chr 1:91,272,680...91,284,498 		JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression ISO 1,4-dioxane results in increased expression of DDIAS mRNA CTD PMID:33693819 NCBI chr 1:156,318,559...156,342,869
Ensembl chr 1:156,318,563...156,342,869 		JBrowse link
G Dglucy D-glutamate cyclase increases expression ISO 1,4-dioxane results in increased expression of DGLUCY mRNA CTD PMID:33693819 NCBI chr 6:125,785,075...125,860,496
Ensembl chr 6:125,785,087...125,860,496 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO 1,4-dioxane results in increased expression of EDA2R mRNA CTD PMID:33693819 NCBI chr  X:66,225,557...66,280,674
Ensembl chr  X:66,236,111...66,280,663 		JBrowse link
G Egr1 early growth response 1 increases expression ISO 1,4-dioxane results in increased expression of EGR1 mRNA CTD PMID:33693819 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 1,4-dioxane results in increased expression of EPHX1 mRNA CTD PMID:33693819 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 1,4-dioxane results in decreased expression of ERBB4 mRNA CTD PMID:33693819 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression ISO 1,4-dioxane results in increased expression of FITM1 mRNA CTD PMID:33693819 NCBI chr15:33,034,705...33,035,974
Ensembl chr15:33,034,688...33,035,974 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 decreases expression ISO 1,4-dioxane results in decreased expression of FRAS1 mRNA CTD PMID:33693819 NCBI chr14:13,095,370...13,506,895
Ensembl chr14:13,095,370...13,504,664 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO 1,4-dioxane results in increased expression of GSTA1 mRNA CTD PMID:33693819 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO 1,4-dioxane results in increased expression of GSTM1 mRNA CTD PMID:33693819 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO 1,4-dioxane results in increased expression of GSTM2 mRNA CTD PMID:33693819 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO 1,4-dioxane results in increased expression of GSTM3 mRNA CTD PMID:33693819 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO 1,4-dioxane results in increased expression of GSTP1 mRNA CTD PMID:33693819 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO
EXP 		1,4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 PMID:37258237 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO 1,4-dioxane results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:246,114,096...246,159,228 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 increases expression ISO 1,4-dioxane results in increased expression of HES1 mRNA CTD PMID:33693819 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061 		JBrowse link
G Hexb hexosaminidase subunit beta decreases expression ISO 1,4-dioxane results in decreased expression of HEXB mRNA CTD PMID:33693819 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO 1,4-dioxane results in increased expression of ID1 mRNA CTD PMID:33693819 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO 1,4-dioxane results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO 1,4-dioxane results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:30,715,602...30,733,746 		JBrowse link
G Meg3 maternally expressed 3 decreases expression ISO 1,4-dioxane results in decreased expression of MEG3 mRNA CTD PMID:33693819 NCBI chr 6:134,274,056...134,306,249 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP 1,4-dioxane results in increased expression of MGMT mRNA CTD PMID:22084566 PMID:30155721 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO 1,4-dioxane results in decreased expression of NAALADL2 mRNA CTD PMID:33693819 NCBI chr 2:108,568,000...109,920,650
Ensembl chr 2:108,573,985...109,920,756 		JBrowse link
G Ncmap noncompact myelin associated protein decreases expression ISO 1,4-dioxane results in decreased expression of NCMAP mRNA CTD PMID:33693819 NCBI chr 5:152,893,173...152,921,175
Ensembl chr 5:152,894,316...152,902,414 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 increases expression ISO 1,4-dioxane results in increased expression of NHERF1 protein CTD PMID:22434383 NCBI chr10:100,902,165...100,919,265
Ensembl chr10:100,901,227...100,919,579 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP 1,4-dioxane results in increased expression of PCNA mRNA CTD PMID:30155721 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO 1,4-dioxane results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:41,422,561...41,671,226
Ensembl chr  X:41,426,101...41,671,226 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO 1,4-dioxane results in increased expression of PHLDA3 mRNA CTD PMID:33693819 NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO 1,4-dioxane results in increased expression of PIM1 mRNA CTD PMID:33693819 NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO 1,4-dioxane results in decreased expression of PPP1R10 mRNA CTD PMID:33693819 NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,827,802...2,842,418 		JBrowse link
G Pygo1 pygopus family PHD finger 1 decreases expression ISO 1,4-dioxane results in decreased expression of PYGO1 mRNA CTD PMID:33693819 NCBI chr 8:82,546,866...82,565,526
Ensembl chr 8:82,546,848...82,565,523 		JBrowse link
G Rad51 RAD51 recombinase increases expression EXP 1,4-dioxane results in increased expression of RAD51 mRNA CTD PMID:37258237 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO 1,4-dioxane results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:161,445,512...161,458,680 		JBrowse link
G Rcan2 regulator of calcineurin 2 decreases expression ISO 1,4-dioxane results in decreased expression of RCAN2 mRNA CTD PMID:33693819 NCBI chr 9:24,456,861...24,674,234
Ensembl chr 9:24,456,861...24,672,189 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression ISO 1,4-dioxane results in decreased expression of RGS1 mRNA CTD PMID:33693819 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:58,568,844...58,573,187 		JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression ISO 1,4-dioxane results in decreased expression of RSRP1 mRNA CTD PMID:33693819 NCBI chr 5:152,431,448...152,435,202
Ensembl chr 5:152,431,478...152,435,126 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO 1,4-dioxane results in decreased expression of H2-AB1 mRNA CTD PMID:33693819 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118 		JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO 1,4-dioxane results in increased expression of SERPINA7 mRNA CTD PMID:33693819 NCBI chr  X:107,452,044...107,510,958
Ensembl chr  X:107,452,044...107,457,681 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 increases expression ISO 1,4-dioxane results in increased expression of SLC17A8 mRNA CTD PMID:33693819 NCBI chr 7:25,881,557...25,936,837
Ensembl chr 7:25,881,557...25,935,410 		JBrowse link
G Sugct succinylCoA:glutarate-CoA transferase decreases expression ISO 1,4-dioxane results in decreased expression of SUGCT mRNA CTD PMID:33693819 NCBI chr17:52,072,012...52,929,852
Ensembl chr17:52,072,052...52,930,281 		JBrowse link
G Sult1c2a sulfotransferase family 1C member 2A decreases expression ISO 1,4-dioxane results in decreased expression of SULT1C2 mRNA CTD PMID:33693819 NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132 		JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression ISO 1,4-dioxane results in increased expression of TGIF1 mRNA CTD PMID:33693819 NCBI chr 9:118,194,735...118,204,354
Ensembl chr 9:118,194,444...118,204,442 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO 1,4-dioxane results in decreased expression of TSC22D3 mRNA CTD PMID:33693819 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases expression ISO 1,4-dioxane results in decreased expression of UGT1A1 mRNA CTD PMID:33693819 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
1,4-dithiane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sord sorbitol dehydrogenase decreases activity EXP 1,4-dithiane results in decreased activity of SORD CTD PMID:2465932 NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100 		JBrowse link
azetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CCL3 protein] CTD PMID:26522449 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of CTSB protein] CTD PMID:26522449 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO azetidine inhibits the reaction [Adenosine Triphosphate results in increased secretion of CXCL2 protein] CTD PMID:26522449 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein] CTD PMID:26522449 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein] CTD PMID:26522449 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein] CTD PMID:26522449 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of MMP9 protein] CTD PMID:26522449 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate affects the localization of NFATC1 protein] CTD PMID:26522449 NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of NOS2 protein] CTD PMID:26522449 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO azetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased expression of P2RX7 protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased expression of P2RX7 protein] CTD PMID:26522449 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO azetidine analog inhibits the reaction [Adenosine Triphosphate results in decreased secretion of TIMP1 protein] CTD PMID:26522449 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO azetidine analog inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of TNF protein]; azetidine analog inhibits the reaction [Adenosine Triphosphate results in increased secretion of TNF protein] CTD PMID:26522449 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 affects localization ISO azetidine affects the localization of TRP53 protein CTD PMID:18813348 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
N-nitrosopiperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine CTD PMID:11774366 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO N-nitrosopiperidine results in increased cleavage of PARP1 protein CTD PMID:17929238 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
oxirane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Ethylene Oxide results in increased expression of APEX1 protein CTD PMID:16051529 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Casp3 caspase 3 affects activity ISO Ethylene Oxide analog affects the activity of CASP3 protein CTD PMID:16311010 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased metabolism of ethylene] which results in increased abundance of Ethylene Oxide CTD PMID:21785163 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects metabolic processing ISO
EXP 		EPHX1 protein affects the metabolism of Ethylene Oxide CTD PMID:11437638 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 protein affects the abundance of Ethylene Oxide metabolite CTD PMID:17416773 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO Ethylene Oxide results in increased mutagenesis of HPRT1 gene CTD PMID:10636004 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:137,655,680...137,687,712 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO Ethylene Oxide results in increased mutagenesis of KRAS gene CTD PMID:24029818 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression EXP Ethylene Oxide results in increased expression of MPG protein CTD PMID:16051529 NCBI chr10:15,900,697...15,906,981
Ensembl chr10:15,899,635...15,907,052 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression
affects response to substance 		EXP
ISO 		Ethylene Oxide results in increased expression of OGG1 protein
OGG1 protein affects the susceptibility to Ethylene Oxide 		CTD PMID:16051529 PMID:16386346 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604 		JBrowse link
G Polb DNA polymerase beta increases expression EXP Ethylene Oxide results in increased expression of POLB protein CTD PMID:16051529 NCBI chr16:76,081,903...76,105,174
Ensembl chr16:76,081,864...76,108,180 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Ethylene Oxide results in increased expression of TRP53 protein CTD PMID:17162533 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 affects response to substance ISO XRCC3 protein affects the susceptibility to Ethylene Oxide CTD PMID:16386346 NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:136,684,558...136,694,822 		JBrowse link
oxolane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression 		ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA] CTD PMID:28495613 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
increases activity 		ISO tetrahydrofuran results in increased expression of CYP2B10 mRNA
NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA]
tetrahydrofuran results in increased activity of CYP2B10 protein 		CTD PMID:28495613 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I2 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP1A2 mRNA]; NR1I3 protein affects the reaction [tetrahydrofuran results in increased expression of CYP2B10 mRNA] CTD PMID:28495613 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Piperazine analog results in increased expression of BAX protein CTD PMID:28874085 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Piperazine analog results in decreased expression of BCL2 protein CTD PMID:28874085 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Piperazine analog results in increased cleavage of CASP3 protein CTD PMID:28874085 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase increases activity ISO Piperazine analog results in increased activity of CAT protein CTD PMID:28874085 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Piperazine results in increased expression of ICAM1 protein CTD PMID:38360295 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Piperazine results in increased expression of IL1B protein CTD PMID:38360295 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 decreases expression ISO piperazine analog results in decreased expression of IL2 mRNA CTD PMID:11859000 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO Piperazine results in decreased expression of MUC1 protein CTD PMID:38360295 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO Piperazine analog results in increased activity of SOD1 protein CTD PMID:28874085 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Piperazine analog results in decreased expression of TH protein CTD PMID:28874085 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
piperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity 		ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]
piperidine analog results in decreased activity of ACHE protein 		CTD PMID:17681794 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]; piperidine analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:17681794 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO piperidine analog results in decreased activity of BCHE protein CTD PMID:17681794 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] CTD PMID:17706638 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:17706638 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ifng interferon gamma multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IFNG protein] CTD PMID:17706638 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions 		ISO piperidine analog results in decreased expression of IL2 mRNA
piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IL2 protein] 		CTD PMID:11859000 PMID:17706638 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases activity ISO
EXP 		piperidine analog results in decreased activity of SRD5A1 protein CTD PMID:10896124 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:35,514,846...35,548,903 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO
EXP 		piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:27,178,079...27,217,588 		JBrowse link
pyrrolidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh3 histamine receptor H3 multiple interactions EXP
ISO 		pyrrolidine binds to and results in decreased activity of HRH3 protein CTD PMID:17169555 NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:187,569,175...187,574,259 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [pyrrolidine analog binds to Palladium binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Palladium binds to Mefenamic Acid] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Diclofenac] which results in decreased activity of PON1 protein; [pyrrolidine analog binds to Platinum binds to Mefenamic Acid] which results in decreased activity of PON1 protein CTD PMID:29512227 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
tetrahydrothiophene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 increases chemical synthesis ISO GSTA1 protein results in increased chemical synthesis of tetrahydrothiophene CTD PMID:12429583 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
triethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions EXP triethylenediamine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein] CTD PMID:19111564 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          carbon atom 20706
            organic molecular entity 20706
              organic fundamental parent 16947
                heterocyclic organic fundamental parent 4080
                  saturated organic heterocyclic parent 105
                    saturated organic heterobicyclic parent + 1
                    saturated organic heteromonocyclic parent + 104
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    main group molecular entity 20809
                      s-block molecular entity 20147
                        hydrogen molecular entity 20117
                          hydrides 17673
                            organic hydride 16947
                              organic fundamental parent 16947
                                heterocyclic organic fundamental parent 4080
                                  saturated organic heterocyclic parent 105
                                    saturated organic heterobicyclic parent + 1
                                    saturated organic heteromonocyclic parent + 104
paths to the root