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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:senecionan
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Accession:CHEBI:36330 term browser browse the term
Definition:A pyrrolizine alkaloid that has formula C18H29NO2.
Synonyms:related_synonym: (3Z,5R,6S,14aR,14bR)-3-ethylidene-5,6-dimethyl-2,3,4,5,6,7,9,11,13,14,14a,14b-dodecahydro[1,6]dioxacyclododecino[2,3,4-gh]pyrrolizine;   Formula=C18H29NO2;   InChI=1S/C18H29NO2/c1-4-15-9-13(2)14(3)10-20-12-16-5-7-19-8-6-17(18(16)19)21-11-15/h4-5,13-14,17-18H,6-12H2,1-3H3/b15-4-/t13-,14-,17-,18-/m1/s1;   InChIKey=HJOOXTWCVPOHPT-MNHUKLIDSA-N;   SMILES=C1OCC=2[C@@]3([C@H](OC/C(/C[C@H]([C@@H]1C)C)=C(/[H])\\C)CCN3CC2)[H]



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erucifoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression ISO erucifoline results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
riddelliine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 decreases expression EXP riddelliine results in decreased expression of ABCB9 mRNA CTD PMID:18047722 NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP riddelliine results in increased expression of ABCC3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 decreases expression EXP riddelliine results in decreased expression of ABCC8 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP riddelliine results in decreased expression of ABCC9 mRNA CTD PMID:18047727 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Adm adrenomedullin decreases expression EXP riddelliine results in decreased expression of ADM mRNA CTD PMID:18047727 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP riddelliine results in increased expression of AHR mRNA CTD PMID:18047727 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA CTD PMID:33884520 NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273
JBrowse link
G Arid2 AT-rich interaction domain 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA CTD PMID:33884520 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
JBrowse link
G Atp13a5 ATPase 13A5 decreases expression EXP riddelliine results in decreased expression of ATP13A5 mRNA CTD PMID:18047722 NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA CTD PMID:33884520 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA CTD PMID:33884520 NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Bard1 BRCA1 associated RING domain 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA CTD PMID:33884520 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Blm BLM RecQ like helicase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA CTD PMID:33884520 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Bora bora, aurora kinase A activator multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA CTD PMID:33884520 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA CTD PMID:33884520 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA CTD PMID:33884520 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brip1 BRCA1 interacting DNA helicase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA CTD PMID:33884520 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA CTD PMID:33884520 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA CTD PMID:33884520 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA CTD PMID:33884520 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc23 cell division cycle 23 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA CTD PMID:33884520 NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA CTD PMID:33884520 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA CTD PMID:33884520 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA CTD PMID:33884520 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA CTD PMID:33884520 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA CTD PMID:33884520 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA CTD PMID:33884520 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP riddelliine results in increased expression of CES2 mRNA CTD PMID:18047722 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Clspn claspin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA CTD PMID:33884520 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression EXP riddelliine results in increased expression of CXCR1 mRNA CTD PMID:18047727 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP26A1 mRNA CTD PMID:18047727 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP riddelliine results in decreased expression of CYP2C mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP riddelliine results in increased expression of CYP2C12 mRNA CTD PMID:18047727 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP riddelliine results in decreased expression of CYP2C13 mRNA CTD PMID:18047727 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP riddelliine results in decreased expression of CYP2C22 mRNA CTD PMID:18047727 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP2E1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 decreases expression EXP riddelliine results in decreased expression of CYP3A18 mRNA CTD PMID:18047727 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
increases response to substance
multiple interactions
increases metabolic processing
EXP
ISO
riddelliine results in decreased expression of CYP3A2 mRNA
CYP3A4 protein results in increased susceptibility to riddelliine
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA
CTD PMID:18047727 PMID:32910235 PMID:33884520 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP riddelliine results in increased expression of CYP3A9 mRNA CTD PMID:18047727 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 decreases expression EXP riddelliine results in decreased expression of CYP4A8 mRNA CTD PMID:18047727 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA CTD PMID:33884520 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA CTD PMID:33884520 NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G E2f8 E2F transcription factor 8 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA CTD PMID:33884520 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Egr1 early growth response 1 increases expression EXP riddelliine results in increased expression of EGR1 mRNA CTD PMID:18047727 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression EXP riddelliine results in decreased expression of ENPP2 mRNA CTD PMID:18047727 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA CTD PMID:33884520 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
JBrowse link
G F11r F11 receptor decreases expression EXP riddelliine results in decreased expression of F11R mRNA CTD PMID:18047727 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression EXP riddelliine results in decreased expression of F3 mRNA CTD PMID:18047727 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F7 coagulation factor VII increases expression EXP riddelliine results in increased expression of F7 mRNA CTD PMID:18047727 NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fanca FA complementation group A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA CTD PMID:33884520 NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527
JBrowse link
G Fancb FA complementation group B multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA CTD PMID:33884520 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fancc FA complementation group C multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA CTD PMID:33884520 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA CTD PMID:33884520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP riddelliine results in increased expression of FAS mRNA CTD PMID:18047727 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA CTD PMID:33884520 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression EXP riddelliine results in increased expression of FMO5 mRNA CTD PMID:18047722 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA CTD PMID:33884520 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP riddelliine results in increased expression of GSTA3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP riddelliine results in decreased expression of GSTM1 mRNA CTD PMID:18047727 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP riddelliine results in decreased expression of GSTM2 mRNA CTD PMID:18047727 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
increases expression
EXP
ISO
riddelliine results in increased phosphorylation of H2AX protein
riddelliine results in increased expression of H2AX protein
CTD PMID:31154085 PMID:31289892 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP riddelliine results in increased expression of HGF mRNA CTD PMID:18047727 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP riddelliine results in increased expression of IGFBP1 mRNA CTD PMID:18047727 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP riddelliine results in increased expression of IGFBP2 mRNA CTD PMID:18047727 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il11 interleukin 11 increases expression EXP riddelliine results in increased expression of IL11 mRNA CTD PMID:18047727 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il15 interleukin 15 increases expression EXP riddelliine results in increased expression of IL15 mRNA CTD PMID:18047727 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il7 interleukin 7 decreases expression EXP riddelliine results in decreased expression of IL7 mRNA CTD PMID:18047727 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP riddelliine results in decreased expression of INMT mRNA CTD PMID:18047722 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP riddelliine results in increased expression of ITGA4 mRNA CTD PMID:18047727 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP riddelliine results in decreased expression of ITGA6 mRNA CTD PMID:18047727 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
increases expression
EXP riddelliine results in increased phosphorylation of and results in increased activity of KDR protein
riddelliine results in increased expression of KDR protein
CTD PMID:12460743 PMID:15384251 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA CTD PMID:33884520 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif23 kinesin family member 23 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA CTD PMID:33884520 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO riddelliine results in increased mutagenesis of KRAS gene CTD PMID:13678655 PMID:20737008 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lepr leptin receptor increases expression EXP riddelliine results in increased expression of LEPR mRNA CTD PMID:18047727 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA CTD PMID:33884520 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression EXP riddelliine results in decreased expression of MMP7 mRNA CTD PMID:18047727 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA CTD PMID:33884520 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA CTD PMID:33884520 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA CTD PMID:33884520 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Mt1 metallothionein 1 increases expression EXP riddelliine results in increased expression of MT1A mRNA CTD PMID:18047727 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP riddelliine results in decreased expression of MTHFD2 mRNA CTD PMID:18047727 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Nbn nibrin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA CTD PMID:33884520 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP riddelliine results in increased expression of NQO1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pbrm1 polybromo 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA CTD PMID:33884520 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
JBrowse link
G Phf10 PHD finger protein 10 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA CTD PMID:33884520 NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA CTD PMID:33884520 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA CTD PMID:33884520 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA CTD PMID:33884520 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plk4 polo-like kinase 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA CTD PMID:33884520 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA CTD PMID:33884520 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression EXP riddelliine results in decreased expression of PPARG mRNA CTD PMID:18047727 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA CTD PMID:33884520 NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA CTD PMID:33884520 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA CTD PMID:33884520 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA CTD PMID:33884520 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Prc1 protein regulator of cytokinesis 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA CTD PMID:33884520 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prkca protein kinase C, alpha increases expression EXP riddelliine results in increased expression of PRKCA mRNA CTD PMID:18047727 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP riddelliine results in increased expression of PRKCZ mRNA CTD PMID:18047727 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA CTD PMID:33884520 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA CTD PMID:33884520 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
JBrowse link
G Rad21 RAD21 cohesin complex component multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA CTD PMID:33884520 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA CTD PMID:33884520 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA CTD PMID:33884520 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA CTD PMID:33884520 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Ren renin increases expression EXP riddelliine results in increased expression of REN mRNA CTD PMID:18047727 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA CTD PMID:33884520 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
JBrowse link
G Rfc2 replication factor C subunit 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA CTD PMID:33884520 NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557
JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA CTD PMID:33884520 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA CTD PMID:33884520 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rfc5 replication factor C subunit 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA CTD PMID:33884520 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rpa1 replication protein A1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA CTD PMID:33884520 NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 decreases expression EXP riddelliine results in decreased expression of S1PR2 mRNA CTD PMID:18047727 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases expression EXP riddelliine results in decreased expression of SLC13A5 mRNA CTD PMID:18047722 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression EXP riddelliine results in decreased expression of SLC16A4 mRNA CTD PMID:18047722 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP riddelliine results in decreased expression of SLC22A6 mRNA CTD PMID:18047722 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP riddelliine results in decreased expression of SLC22A8 mRNA CTD PMID:18047722 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc25a21 solute carrier family 25 member 21 increases expression EXP riddelliine results in increased expression of SLC25A21 mRNA CTD PMID:18047722 NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP riddelliine results in decreased expression of SLC25A30 mRNA CTD PMID:18047722 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression EXP riddelliine results in increased expression of SLC7A5 mRNA CTD PMID:18047727 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Smarca2 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA CTD PMID:33884520 NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
JBrowse link
G Smarcc1 SWI/SNF related BAF chromatin remodeling complex subunit C1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA CTD PMID:33884520 NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA CTD PMID:33884520 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP riddelliine results in increased expression of SRC mRNA CTD PMID:18047727 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stag2 STAG2 cohesin complex component multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA CTD PMID:33884520 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA CTD PMID:33884520 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP riddelliine results in decreased expression of SULT1C1 mRNA CTD PMID:18047722 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link
G Tgfa transforming growth factor alpha decreases expression EXP riddelliine results in decreased expression of TGFA mRNA CTD PMID:18047727 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tlk1 tousled-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA CTD PMID:33884520 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP riddelliine results in decreased expression of TNF mRNA CTD PMID:18047727 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression EXP riddelliine results in increased expression of TNFSF10 mRNA CTD PMID:18047727 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA CTD PMID:33884520 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 increases expression
increases mutagenesis
EXP
ISO
riddelliine results in increased expression of TP53 protein
riddelliine results in increased mutagenesis of TRP53 gene
CTD PMID:12460743 PMID:13678655 PMID:20737008 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA CTD PMID:33884520 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
senecionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 decreases expression ISO senecionine results in decreased expression of ABCA3 protein CTD PMID:35357534 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO senecionine results in decreased expression of ABCB11 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO senecionine results in decreased expression of ABCB1 mRNA CTD PMID:31606820 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP senecionine results in increased expression of ABCB1B mRNA CTD PMID:32419051 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO senecionine results in decreased expression of ABCB4 mRNA CTD PMID:31606820 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO senecionine results in increased expression of ABCC1 mRNA CTD PMID:31606820 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO senecionine results in decreased expression of ABCC2 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
EXP
ISO
senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA
CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression ISO senecionine results in decreased expression of ABCC4 mRNA CTD PMID:31606820 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO senecionine results in decreased expression of ABCC6 mRNA CTD PMID:26100227 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abhd11 abhydrolase domain containing 11 increases expression ISO senecionine results in increased expression of ABHD11 protein CTD PMID:35357534 NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 increases expression ISO senecionine results in increased expression of ABTB2 protein CTD PMID:35357534 NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO senecionine results in increased expression of ACAA1A protein CTD PMID:35357534 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO senecionine results in increased expression of ACAA1B protein CTD PMID:35357534 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acot13 acyl-CoA thioesterase 13 increases expression ISO senecionine results in increased expression of ACOT13 protein CTD PMID:35357534 NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO senecionine results in increased expression of ACOT2 protein CTD PMID:35357534 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression ISO senecionine results in increased expression of ACOT3 protein CTD PMID:35357534 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression ISO senecionine results in increased expression of ACOT4 protein CTD PMID:35357534 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSL3 mRNA CTD PMID:26100227 NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO senecionine results in decreased expression of ACSL4 protein CTD PMID:35357534 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 decreases expression ISO senecionine results in decreased expression of ACSM3 mRNA CTD PMID:26100227 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Acss3 acyl-CoA synthetase short-chain family member 3 increases expression ISO senecionine results in increased expression of ACSS3 protein CTD PMID:35357534 NCBI chr 7:42,241,261...42,450,209
Ensembl chr 7:42,242,652...42,450,230
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP senecionine results in decreased expression of ACTG2 mRNA CTD PMID:34185104 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP senecionine results in increased expression of ADAM8 mRNA CTD PMID:32419051 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression ISO senecionine results in increased expression of ADH1 protein CTD PMID:35357534 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Aff3 ALF transcription elongation factor 3 decreases expression ISO senecionine results in decreased expression of AFF3 mRNA CTD PMID:26100227 NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247
JBrowse link
G Agxt alanine--glyoxylate aminotransferase decreases expression ISO senecionine results in decreased expression of AGXT mRNA CTD PMID:26100227 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression ISO senecionine results in decreased expression of AIF1 protein CTD PMID:35357534 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO senecionine results in increased expression of AKAP12 protein CTD PMID:35357534 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP senecionine results in increased expression of ALDH1A1 mRNA CTD PMID:32419051 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO senecionine results in increased expression of ALDH1B1 protein CTD PMID:35357534 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO senecionine results in increased expression of ALDH6A1 mRNA CTD PMID:26100227 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 decreases expression ISO senecionine results in decreased expression of ALDH8A1 mRNA CTD PMID:26100227 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
JBrowse link
G Anapc2 anaphase promoting complex subunit 2 increases expression ISO senecionine results in increased expression of ANAPC2 protein CTD PMID:35357534 NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression EXP senecionine results in decreased expression of ANKRD1 mRNA CTD PMID:34185104 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Anxa1 annexin A1 increases expression ISO senecionine results in increased expression of ANXA1 protein CTD PMID:35357534 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apcs amyloid P component, serum decreases expression ISO senecionine results in decreased expression of APCS protein CTD PMID:35357534 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apob apolipoprotein B decreases expression ISO senecionine results in decreased expression of APOB protein CTD PMID:35357534 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO senecionine results in decreased expression of APOC1 protein CTD PMID:35357534 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G Apoh apolipoprotein H decreases expression ISO senecionine results in decreased expression of APOH protein CTD PMID:35357534 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Apom apolipoprotein M decreases expression ISO senecionine results in decreased expression of APOM protein CTD PMID:35357534 NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550
JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO senecionine results in decreased expression of AQP4 protein CTD PMID:35357534 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Aqp8 aquaporin 8 increases expression ISO senecionine results in increased expression of AQP8 protein CTD PMID:35357534 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Areg amphiregulin increases expression ISO senecionine results in increased expression of AREG mRNA CTD PMID:26100227 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A increases expression EXP senecionine results in increased expression of ARHGAP11A mRNA CTD PMID:32419051 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Arl6ip1 ARL6 interacting reticulophagy regulator 1 decreases expression ISO senecionine results in decreased expression of ARL6IP1 protein CTD PMID:35357534 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
JBrowse link
G Arl6ip4 ARF like GTPase 6 interacting protein 4 decreases expression ISO senecionine results in decreased expression of ARL6IP4 protein CTD PMID:35357534 NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression EXP senecionine results in increased expression of ATAD2 mRNA CTD PMID:32419051 NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO senecionine results in increased expression of ATF3 protein CTD PMID:35357534 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp13a2 ATPase cation transporting 13A2 decreases expression ISO senecionine results in decreased expression of ATP13A2 protein CTD PMID:35357534 NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 increases expression ISO senecionine results in increased expression of ATP2A3 protein CTD PMID:35357534 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp5if1 ATP synthase inhibitory factor subunit 1 decreases expression ISO senecionine results in decreased expression of ATP5IF1 protein CTD PMID:35357534 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
JBrowse link
G Atp6v1h ATPase H+ transporting V1 subunit H increases expression ISO senecionine results in increased expression of ATP6V1H protein CTD PMID:35357534 NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962
JBrowse link
G Atpaf2 ATP synthase mitochondrial F1 complex assembly factor 2 increases expression ISO senecionine results in increased expression of ATPAF2 protein CTD PMID:35357534 NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026
JBrowse link
G Axin2 axin 2 decreases expression ISO senecionine results in decreased expression of AXIN2 mRNA CTD PMID:31606820 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G B3galt1 Beta-1,3-galactosyltransferase 1 decreases expression ISO senecionine results in decreased expression of B3GALT1 protein CTD PMID:35357534 NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression EXP
ISO
senecionine results in decreased expression of BAAT mRNA CTD PMID:24641316 PMID:26100227 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO senecionine results in decreased expression of BCL2L1 protein CTD PMID:29458164 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO senecionine results in increased expression of BCL3 protein CTD PMID:35357534 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO senecionine results in decreased expression of BNIP3 protein CTD PMID:35357534 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bod1l1 biorientation of chromosomes in cell division 1-like 1 decreases expression ISO senecionine results in decreased expression of BOD1L protein CTD PMID:35357534 NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
JBrowse link
G Bpgm bisphosphoglycerate mutase increases expression ISO senecionine results in increased expression of BPGM protein CTD PMID:35357534 NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
JBrowse link
G Btc betacellulin increases expression ISO senecionine results in increased expression of BTC protein CTD PMID:35357534 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
JBrowse link
G C3 complement C3 decreases expression ISO senecionine results in decreased expression of C3 protein CTD PMID:35357534 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression EXP senecionine results in increased expression of C3AR1 mRNA CTD PMID:34185104 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C4b complement C4B decreases expression ISO senecionine results in decreased expression of C4B protein CTD PMID:35357534 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G C5 complement C5 decreases expression ISO senecionine results in decreased expression of C5 protein CTD PMID:35357534 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO senecionine results in increased expression of CAMP protein CTD PMID:35357534 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Car1 carbonic anhydrase 1 increases expression ISO senecionine results in increased expression of CA1 protein CTD PMID:35357534 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO senecionine results in increased expression of CA2 protein CTD PMID:35357534 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car5a carbonic anhydrase 5A increases expression ISO senecionine results in increased expression of CA5A protein CTD PMID:35357534 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Car5b carbonic anhydrase 5B increases expression ISO senecionine results in increased expression of CA5B protein CTD PMID:35357534 NCBI chr  X:30,474,697...30,534,797
Ensembl chr  X:30,474,784...30,533,837
JBrowse link
G Casp12 caspase 12 increases expression EXP senecionine results in increased expression of CASP12 mRNA CTD PMID:32419051 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP3 protein CTD PMID:29458164 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO senecionine results in increased activity of and results in increased cleavage of CASP8 protein CTD PMID:29458164 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO senecionine results in increased activity of CASP9 protein CTD PMID:29458164 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 decreases expression ISO senecionine results in decreased expression of CAV1 protein CTD PMID:35357534 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cavin3 caveolae associated protein 3 decreases expression ISO senecionine results in decreased expression of CAVIN3 protein CTD PMID:35357534 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Ccdc137 coiled-coil domain containing 137 decreases expression ISO senecionine results in decreased expression of CCDC137 protein CTD PMID:35357534 NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158
JBrowse link
G Ccna2 cyclin A2 increases expression EXP senecionine results in increased expression of CCNA2 mRNA CTD PMID:32419051 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne2 cyclin E2 increases expression EXP senecionine results in increased expression of CCNE2 mRNA CTD PMID:32419051 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Ccng1 cyclin G1 increases expression EXP senecionine results in increased expression of CCNG1 mRNA CTD PMID:32419051 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccpg1 cell cycle progression 1 decreases expression ISO senecionine results in decreased expression of CCPG1 protein CTD PMID:35357534 NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
JBrowse link
G Cd163 CD163 molecule decreases expression ISO senecionine results in decreased expression of CD163 protein CTD PMID:35357534 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd177 CD177 molecule increases expression ISO senecionine results in increased expression of CD177 protein CTD PMID:35357534 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
JBrowse link
G Cd300lg Cd300 molecule-like family member G decreases expression ISO senecionine results in decreased expression of CD300LG protein CTD PMID:35357534 NCBI chr10:86,991,886...87,009,248
Ensembl chr10:86,991,921...87,008,733
JBrowse link
G Cd47 Cd47 molecule increases expression ISO senecionine results in increased expression of CD47 mRNA; senecionine results in increased expression of CD47 protein CTD PMID:35357534 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cdadc1 cytidine and dCMP deaminase domain containing 1 decreases expression ISO senecionine results in decreased expression of CDADC1 protein CTD PMID:35357534 NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576
JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 decreases expression ISO senecionine results in decreased expression of CDKAL1 protein CTD PMID:35357534 NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP
ISO
senecionine results in increased expression of CDKN1A mRNA
senecionine results in increased expression of CDKN1A protein
CTD PMID:32419051 PMID:35357534 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cel carboxyl ester lipase decreases expression ISO senecionine results in decreased expression of CEL protein CTD PMID:35357534 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
JBrowse link
G Cenpq centromere protein Q increases expression EXP senecionine results in increased expression of CENPQ mRNA CTD PMID:32419051 NCBI chr 9:19,957,122...19,972,807
Ensembl chr 9:19,957,048...19,972,789
JBrowse link
G Cenpw centromere protein W increases expression EXP senecionine results in increased expression of CENPW mRNA CTD PMID:32419051 NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
JBrowse link
G Cep97 centrosomal protein 97 increases expression ISO senecionine results in increased expression of CEP97 protein CTD PMID:35357534 NCBI chr11:44,683,503...44,711,471
Ensembl chr11:44,683,506...44,711,471
JBrowse link
G Cfh complement factor H decreases expression ISO senecionine results in decreased expression of CFH protein CTD PMID:35357534 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cgnl1 cingulin-like 1 decreases expression ISO senecionine results in decreased expression of CGNL1 protein CTD PMID:35357534 NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917
JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 increases expression ISO senecionine results in increased expression of CHAMP1 protein CTD PMID:35357534 NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984
JBrowse link
G Chtop chromatin target of PRMT1 decreases expression ISO senecionine results in decreased expression of CHTOP protein CTD PMID:35357534 NCBI chr 2:175,981,266...175,992,820
Ensembl chr 2:175,981,271...175,992,748
JBrowse link
G Cib1 calcium and integrin binding 1 increases expression ISO senecionine results in increased expression of CIB1 protein CTD PMID:35357534 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Cir1 corepressor interacting with RBPJ, 1 decreases expression ISO senecionine results in decreased expression of CIR1 protein CTD PMID:35357534 NCBI chr 3:58,158,923...58,188,799
Ensembl chr 3:58,158,951...58,188,789
JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression EXP senecionine results in increased expression of CKAP2 mRNA CTD PMID:32419051 NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 decreases expression ISO senecionine results in decreased expression of CKMT1 protein CTD PMID:35357534 NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression EXP senecionine results in decreased expression of CKMT2 mRNA CTD PMID:34185104 NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430
JBrowse link
G Clec3b C-type lectin domain family 3, member B decreases expression ISO senecionine results in decreased expression of CLEC3B protein CTD PMID:35357534 NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835
JBrowse link
G Clec4a1 C-type lectin domain family 4, member A1 increases expression EXP senecionine results in increased expression of CLEC4A1 mRNA CTD PMID:34185104 NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP
ISO
senecionine results in decreased expression of CLEC4F mRNA
senecionine results in decreased expression of CLEC4F protein
CTD PMID:32419051 PMID:35357534 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein decreases expression ISO senecionine results in decreased expression of CNBP protein CTD PMID:35357534 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
JBrowse link
G Cntrl centriolin decreases expression ISO senecionine results in decreased expression of CNTRL protein CTD PMID:35357534 NCBI chr 3:18,428,147...18,500,362
Ensembl chr 3:18,428,103...18,500,380
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO senecionine results in decreased expression of COL18A1 protein CTD PMID:35357534 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Cops3 COP9 signalosome subunit 3 increases expression ISO senecionine results in increased expression of COPS3 protein CTD PMID:35357534 NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
JBrowse link
G Coro1a coronin 1A increases expression ISO senecionine results in increased expression of CORO1A protein CTD PMID:35357534 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
JBrowse link
G Cpa1 carboxypeptidase A1 decreases expression ISO senecionine results in decreased expression of CPA1 protein CTD PMID:35357534 NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544
JBrowse link
G Cpb2 carboxypeptidase B2 decreases expression ISO senecionine results in decreased expression of CPB2 protein CTD PMID:35357534 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
JBrowse link
G Creld1 cysteine-rich with EGF-like domains 1 decreases expression ISO senecionine results in decreased expression of CRELD1 protein CTD PMID:35357534 NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 decreases expression ISO senecionine results in decreased expression of CRELD2 protein CTD PMID:35357534 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
JBrowse link
G Crip1 cysteine rich protein 1 decreases expression ISO senecionine results in decreased expression of CRIP1 protein CTD PMID:35357534 NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP senecionine results in decreased expression of CSF1R mRNA CTD PMID:32419051 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Ctdnep1 CTD nuclear envelope phosphatase 1 increases expression ISO senecionine results in increased expression of CTDNEP1 protein CTD PMID:35357534 NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781
JBrowse link
G Ctrb1 chymotrypsinogen B1 decreases expression ISO senecionine results in decreased expression of CTRB1 protein CTD PMID:35357534 NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688
JBrowse link
G Ctsg cathepsin G increases expression ISO senecionine results in increased expression of CTSG protein CTD PMID:35357534 NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO senecionine results in decreased expression of CXCL12 protein CTD PMID:35357534 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO senecionine results in increased expression of CXCR4 mRNA CTD PMID:35357534 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP11A1 mRNA CTD PMID:26100227 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1A1 mRNA CTD PMID:26100227 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO senecionine results in increased expression of CYP1A2 mRNA
senecionine results in decreased expression of CYP1A2 mRNA
CTD PMID:26100227 PMID:31606820 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP1B1 mRNA CTD PMID:26100227 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression ISO senecionine results in increased expression of CYP2A13 mRNA CTD PMID:26100227 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO senecionine results in increased expression of CYP2A4 protein CTD PMID:35357534 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
affects expression
ISO senecionine results in increased expression of CYP2B6 mRNA
senecionine affects the expression of CYP2B10 mRNA
CTD PMID:26100227 PMID:31606820 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression ISO senecionine results in decreased expression of CYP2C18 mRNA CTD PMID:26100227 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
decreases expression
ISO senecionine results in increased expression of CYP2E1 mRNA
senecionine results in decreased expression of CYP2E1 mRNA
CTD PMID:26100227 PMID:31606820 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression ISO senecionine results in increased expression of CYP3A43 mRNA CTD PMID:26100227 NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases response to substance
ISO senecionine results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to senecionine
CTD PMID:26100227 PMID:32910235 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression ISO senecionine results in decreased expression of CYP3A5 mRNA CTD PMID:26100227 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO senecionine results in decreased expression of CYP4F12 mRNA CTD PMID:26100227 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP
ISO
senecionine results in decreased expression of CYP7A1 mRNA CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO senecionine results in decreased expression of CYP8B1 mRNA CTD PMID:26100227 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Cyria CYFIP related Rac1 interactor A increases expression EXP senecionine results in increased expression of CYRIA mRNA CTD PMID:32419051 NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668
JBrowse link
G Dbr1 debranching RNA lariats 1 increases expression ISO senecionine results in increased expression of DBR1 protein CTD PMID:35357534 NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030
JBrowse link
G Ddias DNA damage-induced apoptosis suppressor increases expression EXP senecionine results in increased expression of DDIAS mRNA CTD PMID:32419051 NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
JBrowse link
G Dedd death effector domain-containing decreases expression ISO senecionine results in decreased expression of DEDD protein CTD PMID:35357534 NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Dguok deoxyguanosine kinase increases expression ISO senecionine results in increased expression of DGUOK protein CTD PMID:35357534 NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO senecionine results in increased expression of DHRS2 mRNA CTD PMID:26100227 NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO senecionine results in increased expression of DHRS9 mRNA CTD PMID:26100227 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Diaph3 diaphanous-related formin 3 increases expression EXP senecionine results in increased expression of DIAPH3 mRNA CTD PMID:32419051 NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
JBrowse link
G Dip2a disco-interacting protein 2 homolog A decreases expression ISO senecionine results in decreased expression of DIP2A protein CTD PMID:35357534 NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP senecionine results in increased expression of DLGAP5 mRNA CTD PMID:32419051 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 decreases expression ISO senecionine results in decreased expression of DMBT1 protein CTD PMID:35357534 NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO senecionine results in increased expression of DNAJB9 protein CTD PMID:35357534 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 decreases expression ISO senecionine results in decreased expression of DNAJC12 protein CTD PMID:35357534 NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression ISO senecionine results in decreased expression of DNAJC15 protein CTD PMID:35357534 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
JBrowse link
G Dph5 diphthamide biosynthesis 5 increases expression ISO senecionine results in increased expression of DPH5 protein CTD PMID:35357534 NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO senecionine results in decreased expression of DPYD mRNA CTD PMID:26100227 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog increases expression EXP senecionine results in increased expression of DTL mRNA CTD PMID:32419051 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO senecionine results in increased expression of DUSP1 protein CTD PMID:35357534 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dynll2 dynein light chain LC8-type 2 decreases expression ISO senecionine results in decreased expression of DYNLL2 protein CTD PMID:35357534 NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression EXP senecionine results in increased expression of EDA2R mRNA CTD PMID:32419051 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO senecionine results in decreased expression of EGFR protein CTD PMID:35357534 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G decreases expression ISO senecionine results in decreased expression of EIF3G protein CTD PMID:35357534 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B decreases expression ISO senecionine results in decreased expression of EIF4B protein CTD PMID:35357534 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Elf1 E74 like ETS transcription factor 1 decreases expression ISO senecionine results in decreased expression of ELF1 protein CTD PMID:35357534 NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
JBrowse link
G Elovl1 ELOVL fatty acid elongase 1 decreases expression ISO senecionine results in decreased expression of ELOVL1 protein CTD PMID:35357534 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
JBrowse link
G Emilin2 elastin microfibril interfacer 2 increases expression EXP senecionine results in increased expression of EMILIN2 mRNA CTD PMID:34185104 NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352
JBrowse link
G Eng endoglin decreases expression ISO senecionine results in decreased expression of ENG protein CTD PMID:35357534 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Eno3 enolase 3 increases expression ISO senecionine results in increased expression of ENO3 protein CTD PMID:35357534 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression ISO senecionine results in increased expression of ENTPD5 protein CTD PMID:35357534 NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
JBrowse link
G Epha2 Eph receptor A2 increases expression ISO senecionine results in increased expression of EPHA2 protein CTD PMID:35357534 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO senecionine results in decreased expression of EPHX2 mRNA CTD PMID:26100227 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Epm2a EPM2A glucan phosphatase, laforin increases expression ISO senecionine results in increased expression of EPM2A protein CTD PMID:35357534 NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression ISO senecionine results in increased expression of ERP29 protein CTD PMID:35357534 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 increases expression EXP senecionine results in increased expression of ESCO2 mRNA CTD PMID:32419051 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO senecionine results in decreased expression of ESRRA protein CTD PMID:35357534 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Ethe1 ETHE1, persulfide dioxygenase decreases expression EXP senecionine results in decreased expression of ETHE1 mRNA CTD PMID:32419051 NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO senecionine results in increased expression of ETNPPL protein CTD PMID:35357534 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO senecionine results in increased expression of ETS2 protein CTD PMID:35357534 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO senecionine results in decreased expression of ETV6 protein CTD PMID:35357534 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G Ext1 exostosin glycosyltransferase 1 decreases expression ISO senecionine results in decreased expression of EXT1 protein CTD PMID:35357534 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
JBrowse link
G F13a1 coagulation factor XIII A1 chain increases expression ISO senecionine results in increased expression of F13A1 protein CTD PMID:35357534 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G Fahd2a fumarylacetoacetate hydrolase domain containing 2A increases expression ISO senecionine results in increased expression of FAHD2A protein CTD PMID:35357534 NCBI chr 3:114,657,176...114,665,349
Ensembl chr 3:114,655,865...114,665,356
JBrowse link
G Fancd2 FA complementation group D2 increases expression EXP senecionine results in increased expression of FANCD2 mRNA CTD PMID:32419051 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
senecionine metabolite results in increased expression of FAS mRNA
senecionine results in increased expression of FAS mRNA
CTD PMID:30465738 PMID:32419051 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxo21 F-box protein 21 increases expression ISO senecionine results in increased expression of FBXO21 protein CTD PMID:35357534 NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
JBrowse link
G Fcgr3a Fc gamma receptor 3A increases expression EXP senecionine results in increased expression of FCGR3A mRNA CTD PMID:34185104 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO senecionine results in decreased expression of FDFT1 protein CTD PMID:35357534 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fgl1 fibrinogen-like 1 decreases expression ISO senecionine results in decreased expression of FGL1 protein CTD PMID:35357534 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
JBrowse link
G Fis1 fission, mitochondrial 1 decreases expression ISO senecionine results in decreased expression of FIS1 protein CTD PMID:35357534 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases expression ISO senecionine results in increased expression of FMO3 protein CTD PMID:35357534 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 decreases expression ISO senecionine results in decreased expression of FMO4 mRNA CTD PMID:26100227 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 decreases expression ISO senecionine results in decreased expression of FMO5 mRNA CTD PMID:26100227 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 decreases expression ISO senecionine results in decreased expression of FMR1 protein CTD PMID:35357534 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Fndc3b fibronectin type III domain containing 3B decreases expression ISO senecionine results in decreased expression of FNDC3B protein CTD PMID:35357534 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
JBrowse link
G Folr2 folate receptor beta decreases expression ISO senecionine results in decreased expression of FOLR2 protein CTD PMID:35357534 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724
JBrowse link
G Frmd4b FERM domain containing 4B decreases expression ISO senecionine results in decreased expression of FRMD4B protein CTD PMID:35357534 NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
JBrowse link
G Ftsj3 FtsJ RNA 2'-O-methyltransferase 3 decreases expression ISO senecionine results in decreased expression of FTSJ3 protein CTD PMID:35357534 NCBI chr10:91,180,945...91,187,389
Ensembl chr10:91,180,696...91,187,397
JBrowse link
G Fyb2 FYN binding protein 2 decreases expression ISO senecionine results in decreased expression of FYB2 protein CTD PMID:35357534 NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910
JBrowse link
G Fyttd1 forty-two-three domain containing 1 decreases expression ISO senecionine results in decreased expression of FYTTD1 protein CTD PMID:35357534 NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO senecionine results in increased expression of G0S2 protein CTD PMID:35357534 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO senecionine results in increased expression of G6PDX protein CTD PMID:35357534 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gc GC, vitamin D binding protein decreases expression ISO senecionine results in decreased expression of GC protein CTD PMID:35357534 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
JBrowse link
G Gckr glucokinase regulator increases expression ISO senecionine results in increased expression of GCKR protein CTD PMID:35357534 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gcsh glycine cleavage system protein H increases expression ISO senecionine results in increased expression of GCSH protein CTD PMID:35357534 NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO senecionine results in increased expression of GEM mRNA CTD PMID:26100227 NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Ghr growth hormone receptor decreases expression ISO senecionine results in decreased expression of GHR protein CTD PMID:35357534 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Gls glutaminase increases expression ISO senecionine results in increased expression of GLS mRNA CTD PMID:26100227 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Glyat glycine-N-acyltransferase decreases expression ISO senecionine results in decreased expression of GLYAT mRNA CTD PMID:26100227 NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942
JBrowse link
G Gnmt glycine N-methyltransferase increases expression ISO senecionine results in increased expression of GNMT mRNA CTD PMID:26100227 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpatch4 G patch domain containing 4 increases expression ISO senecionine results in increased expression of GPATCH4 protein CTD PMID:35357534 NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684
JBrowse link
G Gpc1 glypican 1 decreases expression EXP senecionine results in decreased expression of GPC1 mRNA CTD PMID:34185104 NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression ISO senecionine results in increased expression of GPCPD1 protein CTD PMID:35357534 NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517
JBrowse link
G Gphn gephyrin decreases expression ISO senecionine results in decreased expression of GPHN mRNA CTD PMID:26100227 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO senecionine results in increased expression of GPRC5A mRNA CTD PMID:26100227 NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
JBrowse link
G Gpsm3 G-protein signaling modulator 3 increases expression ISO senecionine results in increased expression of GPSM3 protein CTD PMID:35357534 NCBI chr20:4,157,123...4,158,984
Ensembl chr20:4,157,123...4,159,035
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP
ISO
senecionine results in increased activity of GPT protein
POR protein affects the reaction [senecionine results in increased expression of GPT protein]
CTD PMID:24641316 PMID:31606820 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP senecionine results in increased expression of GRIA3 mRNA CTD PMID:32419051 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096
JBrowse link
G Grn granulin precursor decreases expression ISO senecionine results in decreased expression of GRN protein CTD PMID:35357534 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial increases expression ISO senecionine results in increased expression of GRPEL1 protein CTD PMID:35357534 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression ISO senecionine results in decreased expression of GSTA4 mRNA CTD PMID:26100227 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO senecionine results in increased expression of GSTA1 protein CTD PMID:35357534 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstt1 glutathione S-transferase theta 1 decreases expression ISO senecionine results in decreased expression of GSTT1 mRNA CTD PMID:26100227 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gzma granzyme A decreases expression EXP senecionine results in decreased expression of GZMA mRNA CTD PMID:32419051 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G H1f4 H1.4 linker histone, cluster member decreases expression ISO senecionine results in decreased expression of H1-4 protein CTD PMID:35357534 NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
JBrowse link
G H2ax H2A.X variant histone increases expression ISO senecionine results in increased expression of H2AX protein CTD PMID:31154085 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Haus2 HAUS augmin like complex subunit 2 decreases expression ISO senecionine results in decreased expression of HAUS2 protein CTD PMID:35357534 NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression ISO senecionine results in increased expression of HBA protein CTD PMID:35357534 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hbb hemoglobin subunit beta increases expression ISO senecionine results in increased expression of HBB-B1 protein CTD PMID:35357534 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hdlbp high density lipoprotein binding protein decreases expression ISO senecionine results in decreased expression of HDLBP protein CTD PMID:35357534 NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 increases expression EXP senecionine results in increased expression of HERC6 mRNA CTD PMID:32419051 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hic2 HIC ZBTB transcriptional repressor 2 decreases expression ISO senecionine results in decreased expression of HIC2 protein CTD PMID:35357534 NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO senecionine results in decreased expression of HMGCR protein CTD PMID:35357534 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression EXP senecionine results in increased expression of HMMR mRNA CTD PMID:32419051 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hnf1a HNF1 homeobox A decreases expression ISO senecionine results in decreased expression of HNF1A protein CTD PMID:35357534 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO senecionine results in decreased expression of HNMT mRNA CTD PMID:26100227 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 increases expression ISO senecionine results in increased expression of HOGA1 protein CTD PMID:35357534 NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
JBrowse link
G Hp haptoglobin decreases expression ISO senecionine results in decreased expression of HP protein CTD PMID:35357534 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression ISO senecionine results in increased expression of HSD3B1 protein CTD PMID:35357534 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO senecionine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hypk Huntingtin interacting protein K decreases expression ISO senecionine results in decreased expression of HYPK protein CTD PMID:35357534 NCBI chr 3:108,434,997...108,436,370
Ensembl chr 3:108,432,539...108,436,370
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO senecionine results in increased expression of ICAM1 mRNA CTD PMID:35357534 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 increases expression EXP senecionine results in increased expression of IFIT2 mRNA CTD PMID:32419051 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ift25 intraflagellar transport 25 increases expression ISO senecionine results in increased expression of IFT25 protein CTD PMID:35357534 NCBI chr 5:122,035,588...122,062,421
Ensembl chr 5:122,035,581...122,062,421
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 decreases expression ISO senecionine results in decreased expression of IGFBP4 protein CTD PMID:35357534 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 increases expression ISO senecionine results in increased expression of IGHG1 protein CTD PMID:35357534 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il11 interleukin 11 increases expression ISO senecionine metabolite results in increased expression of IL11 mRNA CTD PMID:30465738 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO senecionine results in decreased expression of IL13RA1 protein CTD PMID:35357534 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681
JBrowse link
G Il17rd interleukin 17 receptor D increases expression EXP senecionine results in increased expression of IL17RD mRNA CTD PMID:32419051 NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556
JBrowse link
G Il1b interleukin 1 beta increases expression ISO senecionine metabolite results in increased expression of IL1B mRNA CTD PMID:30465738 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer decreases expression ISO senecionine results in decreased expression of IL6ST protein CTD PMID:35357534 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression ISO senecionine results in increased expression of IMPDH2 protein CTD PMID:35357534 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
JBrowse link
G Inip INTS3 and NABP interacting protein decreases expression ISO senecionine results in decreased expression of INIP protein CTD PMID:35357534 NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP senecionine results in decreased expression of INMT mRNA CTD PMID:32419051 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Isca1 iron-sulfur cluster assembly 1 increases expression ISO senecionine results in increased expression of ISCA1 protein CTD PMID:35357534 NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO senecionine results in increased expression of ISG15 protein CTD PMID:35357534 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO senecionine results in increased expression of ISG20 mRNA CTD PMID:26100227 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO senecionine results in increased expression of ITGAM protein CTD PMID:35357534 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 decreases expression ISO senecionine results in decreased expression of ITIH2 protein CTD PMID:35357534 NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841
JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 decreases expression ISO senecionine results in decreased expression of ITIH3 protein CTD PMID:35357534 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
JBrowse link
G Itm2b integral membrane protein 2B decreases expression ISO senecionine results in decreased expression of ITM2B protein CTD PMID:35357534 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Jam3 junctional adhesion molecule 3 increases expression EXP senecionine results in increased expression of JAM3 mRNA CTD PMID:32419051 NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression ISO senecionine results in decreased expression of JCHAIN protein CTD PMID:35357534 NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression ISO senecionine results in increased expression of JMJD6 protein CTD PMID:35357534 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO senecionine results in increased expression of JUNB protein CTD PMID:35357534 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kif11 kinesin family member 11 increases expression EXP senecionine results in increased expression of KIF11 mRNA CTD PMID:32419051 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif18a kinesin family member 18A increases expression EXP senecionine results in increased expression of KIF18A mRNA CTD PMID:32419051 NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582
JBrowse link
G Knl1 kinetochore scaffold 1 increases expression EXP senecionine results in increased expression of KNL1 mRNA CTD PMID:32419051 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Kntc1 kinetochore associated 1 increases expression EXP senecionine results in increased expression of KNTC1 mRNA CTD PMID:32419051 NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
JBrowse link
G Krt19 keratin 19 decreases expression ISO senecionine results in decreased expression of KRT19 protein CTD PMID:35357534 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Ktn1 kinectin 1 decreases expression ISO senecionine results in decreased expression of KTN1 protein CTD PMID:35357534 NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases expression ISO senecionine results in decreased expression of KYAT1 mRNA CTD PMID:26100227 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Larp4 La ribonucleoprotein 4 decreases expression ISO senecionine results in decreased expression of LARP4 protein CTD PMID:35357534 NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP senecionine results in increased expression of LBP mRNA CTD PMID:32419051 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO senecionine results in increased expression of LCN2 mRNA CTD PMID:31606820 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lgals2 galectin 2 decreases expression ISO senecionine results in decreased expression of LGALS2 protein CTD PMID:35357534 NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 decreases expression ISO senecionine results in decreased expression of LGR5 mRNA CTD PMID:31606820 NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
JBrowse link
G Lin37 lin-37 DREAM MuvB core complex component decreases expression ISO senecionine results in decreased expression of LIN37 protein CTD PMID:35357534 NCBI chr 1:85,809,065...85,813,235
Ensembl chr 1:85,809,074...85,812,991
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO senecionine results in increased expression of LONP1 protein CTD PMID:35357534 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO senecionine results in decreased expression of LRP1 protein CTD PMID:35357534 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrrc59 leucine rich repeat containing 59 decreases expression ISO senecionine results in decreased expression of LRRC59 protein CTD PMID:35357534 NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533
JBrowse link
G Ltf lactotransferrin increases expression ISO senecionine results in increased expression of LTF protein CTD PMID:35357534 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Lyz2 lysozyme 2 increases expression ISO senecionine results in increased expression of LYZ2 protein CTD PMID:35357534 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Maco1 macoilin 1 decreases expression ISO senecionine results in decreased expression of MACO1 protein CTD PMID:35357534 NCBI chr 5:147,012,416...147,075,265
Ensembl chr 5:147,012,867...147,075,001
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 increases expression EXP senecionine results in increased expression of MAD2L1 mRNA CTD PMID:32419051 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO senecionine results in increased expression of MAFF mRNA
senecionine results in increased expression of MAFF protein
CTD PMID:26100227 PMID:35357534 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO senecionine results in increased expression of MAFK protein CTD PMID:35357534 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048
JBrowse link
G Mal mal, T-cell differentiation protein increases expression EXP senecionine results in increased expression of MAL mRNA CTD PMID:34185104 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
JBrowse link
G Maoa monoamine oxidase A decreases expression ISO senecionine results in decreased expression of MAOA mRNA CTD PMID:26100227 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO senecionine results in increased expression of MAP2K3 protein CTD PMID:35357534 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map7 microtubule-associated protein 7 decreases expression ISO senecionine results in decreased expression of MAP7 protein CTD PMID:35357534 NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574
JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO senecionine results in decreased expression of MAPRE2 protein CTD PMID:35357534 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like increases expression EXP senecionine results in increased expression of MASTL mRNA CTD PMID:32419051 NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO senecionine results in increased expression of MBL2 protein CTD PMID:35357534 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP senecionine results in increased expression of MCM3 mRNA CTD PMID:32419051 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 increases expression EXP senecionine results in increased expression of MCM5 mRNA CTD PMID:32419051 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
JBrowse link
G Mettl21a methyltransferase 21A, HSPA lysine increases expression ISO senecionine results in increased expression of METTL21A protein CTD PMID:35357534 NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550
JBrowse link
G Mgat5 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase decreases expression ISO senecionine results in decreased expression of MGAT5 protein CTD PMID:35357534 NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513
JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 increases expression ISO senecionine results in increased expression of MGME1 protein CTD PMID:35357534 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP senecionine results in increased expression of MGMT mRNA CTD PMID:32419051 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mib2 MIB E3 ubiquitin protein ligase 2 decreases expression ISO senecionine results in decreased expression of MIB2 protein CTD PMID:35357534 NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650
JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 decreases expression ISO senecionine results in decreased expression of MICOS10 protein CTD PMID:35357534 NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP senecionine results in increased expression of MKI67 mRNA CTD PMID:32419051 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO senecionine results in increased expression of MMP1 mRNA CTD PMID:26100227 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
ISO senecionine results in increased expression of MMP9 mRNA
senecionine results in increased expression of MMP9 mRNA; senecionine results in increased expression of MMP9 protein
Leu-Ser-Lys-Leu peptide inhibits the reaction [senecionine results in increased expression of MMP9 mRNA]
CTD PMID:35357534 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mmrn1 multimerin 1 increases expression ISO senecionine results in increased expression of MMRN1 protein CTD PMID:35357534 NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474
JBrowse link
G Mpdu1 mannose-P-dolichol utilization defect 1 decreases expression ISO senecionine results in decreased expression of MPDU1 protein CTD PMID:35357534 NCBI chr10:54,374,719...54,380,301
Ensembl chr10:54,374,725...54,380,447
JBrowse link
G Mpo myeloperoxidase increases expression ISO senecionine results in increased expression of MPO protein CTD PMID:35357534 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mpst mercaptopyruvate sulfurtransferase increases expression ISO senecionine results in increased expression of MPST protein CTD PMID:35357534 NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
JBrowse link
G Mrpl42 mitochondrial ribosomal protein L42 increases expression ISO senecionine results in increased expression of MRPL42 protein CTD PMID:35357534 NCBI chr 7:30,117,977...30,141,757
Ensembl chr 7:30,117,977...30,141,639
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO senecionine results in decreased expression of MSMO1 protein CTD PMID:35357534 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression ISO senecionine results in increased expression of COX3 protein CTD PMID:35357534 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 decreases expression ISO senecionine results in decreased expression of ND3 protein CTD PMID:35357534 NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
JBrowse link
G Mt2A metallothionein 2A increases expression ISO senecionine results in increased expression of MT2 mRNA CTD PMID:31606820 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO senecionine results in increased expression of MTHFD1L protein CTD PMID:35357534 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 decreases expression ISO senecionine results in decreased expression of MTSS1 protein CTD PMID:35357534 NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 decreases expression ISO senecionine results in decreased expression of MTUS1 protein CTD PMID:35357534 NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression EXP senecionine results in increased expression of MYBL1 mRNA CTD PMID:32419051 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP senecionine results in increased expression of MYBL2 mRNA CTD PMID:32419051 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Mybpc3 myosin binding protein C3 decreases expression EXP senecionine results in decreased expression of MYBPC3 mRNA CTD PMID:34185104 NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
JBrowse link
G Myoz2 myozenin 2 decreases expression EXP senecionine results in decreased expression of MYOZ2 mRNA CTD PMID:34185104 NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221
JBrowse link
G N4bp2l1 NEDD4 binding protein 2-like 1 decreases expression ISO senecionine results in decreased expression of N4BP2L1 protein CTD PMID:35357534 NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257
JBrowse link
G Napsa napsin A aspartic peptidase increases expression ISO senecionine results in increased expression of NAPSA protein CTD PMID:35357534 NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H increases expression EXP senecionine results in increased expression of NCAPH mRNA CTD PMID:32419051 NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
JBrowse link
G Ncf4 neutrophil cytosolic factor 4 increases expression ISO senecionine results in increased expression of NCF4 protein CTD PMID:35357534 NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389
JBrowse link
G Ndc80 NDC80 kinetochore complex component increases expression EXP senecionine results in increased expression of NDC80 mRNA CTD PMID:32419051 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Neb nebulin decreases expression ISO senecionine results in decreased expression of NEB mRNA CTD PMID:26100227 NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574
JBrowse link
G Nfia nuclear factor I/A decreases expression ISO senecionine results in decreased expression of NFIA protein CTD PMID:35357534 NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885
JBrowse link
G Nifk nucleolar protein interacting with the FHA domain of MKI67 decreases expression ISO senecionine results in decreased expression of NIFK protein CTD PMID:35357534 NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression ISO senecionine results in decreased expression of NNMT mRNA CTD PMID:26100227 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
JBrowse link
G Nop16 NOP16 nucleolar protein decreases expression ISO senecionine results in decreased expression of NOP16 protein CTD PMID:35357534 NCBI chr17:10,022,950...10,027,867
Ensembl chr17:10,022,932...10,027,867
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO senecionine results in increased expression of NOS2 mRNA CTD PMID:35357534 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase increases expression ISO senecionine results in increased expression of NPL protein CTD PMID:35357534 NCBI chr13:65,655,099...65,697,464
Ensembl chr13:65,655,118...65,697,372
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO senecionine results in increased expression of NQO1 mRNA CTD PMID:26100227 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression EXP
ISO
senecionine results in decreased expression of NR0B2 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression ISO senecionine results in increased expression of NR1D1 protein CTD PMID:35357534 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP
ISO
senecionine results in decreased expression of NR1H4 mRNA
senecionine results in decreased expression of NR1H4 protein
CTD PMID:24641316 PMID:35357534 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO senecionine results in decreased expression of NR1I3 mRNA CTD PMID:31606820 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP senecionine results in decreased expression of NR3C1 mRNA CTD PMID:32419051 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP senecionine results in increased expression of NRCAM mRNA CTD PMID:32419051 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
JBrowse link
G Nrg1 neuregulin 1 increases expression EXP senecionine results in increased expression of NRG1 mRNA CTD PMID:32419051 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nrp1 neuropilin 1 decreases expression ISO senecionine results in decreased expression of NRP1 protein CTD PMID:35357534 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Ntm neurotrimin decreases expression ISO senecionine results in decreased expression of NTM protein CTD PMID:35357534 NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO senecionine results in decreased expression of NUCKS1 protein CTD PMID:35357534 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Nudt7 nudix hydrolase 7 increases expression ISO senecionine results in increased expression of NUDT7 protein CTD PMID:35357534 NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression EXP senecionine results in increased expression of NUSAP1 mRNA CTD PMID:32419051 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Orm1 orosomucoid 1 decreases expression ISO senecionine results in decreased expression of ORM1 protein CTD PMID:35357534 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial increases expression ISO senecionine results in increased expression of OXSM protein CTD PMID:35357534 NCBI chr15:9,210,443...9,215,852
Ensembl chr15:9,210,547...9,214,558
JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 decreases expression ISO senecionine results in decreased expression of PABPC1 protein CTD PMID:35357534 NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO senecionine results in decreased expression of PARP1 protein CTD PMID:29458164 PMID:35357534 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pclaf PCNA clamp associated factor increases expression EXP senecionine results in increased expression of PCLAF mRNA CTD PMID:32419051 NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO senecionine results in decreased expression of PCSK9 protein CTD PMID:35357534 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pdcl phosducin like increases expression ISO senecionine results in increased expression of PDCL protein CTD PMID:35357534 NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
Ensembl chr 3:21,110,167...21,119,715
JBrowse link
G Pde12 phosphodiesterase 12 increases expression ISO senecionine results in increased expression of PDE12 protein CTD PMID:35357534 NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887
JBrowse link
G Pde7b phosphodiesterase 7B decreases expression ISO senecionine results in decreased expression of PDE7B protein CTD PMID:35357534 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 decreases expression ISO senecionine results in decreased expression of PDIA2 protein CTD PMID:35357534 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 decreases expression ISO senecionine results in decreased expression of PDZRN3 protein CTD PMID:35357534 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
JBrowse link
G Per3 period circadian regulator 3 decreases expression ISO senecionine results in decreased expression of PER3 protein CTD PMID:35357534 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
JBrowse link
G Phf14 PHD finger protein 14 decreases expression ISO senecionine results in decreased expression of PHF14 protein CTD PMID:35357534 NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 decreases expression ISO senecionine results in decreased expression of PID1 protein CTD PMID:35357534 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 increases expression ISO senecionine results in increased expression of PIEZO1 protein CTD PMID:35357534 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
JBrowse link
G Pigr polymeric immunoglobulin receptor decreases expression ISO senecionine results in decreased expression of PIGR protein CTD PMID:35357534 NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases expression ISO senecionine results in decreased expression of PKD2 protein CTD PMID:35357534 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Plcg2 phospholipase C, gamma 2 increases expression ISO senecionine results in increased expression of PLCG2 protein CTD PMID:35357534 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Pld1 phospholipase D1 decreases expression ISO senecionine results in decreased expression of PLD1 protein CTD PMID:35357534 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld4 phospholipase D family, member 4 increases expression EXP senecionine results in increased expression of PLD4 mRNA CTD PMID:34185104 NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376
JBrowse link
G Plg plasminogen decreases expression ISO senecionine results in decreased expression of PLG protein CTD PMID:35357534 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Plin2 perilipin 2 increases expression ISO senecionine results in increased expression of PLIN2 protein CTD PMID:35357534 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plk4 polo-like kinase 4 increases expression EXP senecionine results in increased expression of PLK4 mRNA CTD PMID:32419051 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Pln phospholamban decreases expression EXP senecionine results in decreased expression of PLN mRNA CTD PMID:34185104 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pml PML nuclear body scaffold decreases expression ISO senecionine results in decreased expression of PML protein CTD PMID:35357534 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO senecionine results in increased expression of PNPLA2 protein CTD PMID:35357534 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Polr1g RNA polymerase I subunit G increases expression ISO senecionine results in increased expression of POLR1G protein CTD PMID:35357534 NCBI chr 1:79,007,490...79,010,766
Ensembl chr 1:79,007,490...79,010,766
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
affects response to substance
ISO POR protein affects the reaction [senecionine results in increased expression of GPT protein]
POR protein affects the susceptibility to senecionine
CTD PMID:31606820 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppif peptidylprolyl isomerase F increases expression ISO senecionine results in increased expression of PPIF protein CTD PMID:35357534 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B decreases expression ISO senecionine results in decreased expression of PPP1R3B protein CTD PMID:35357534 NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP senecionine results in increased expression of PRC1 mRNA CTD PMID:32419051 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO senecionine results in increased expression of PRDX3 protein CTD PMID:35357534 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO senecionine results in decreased expression of PRG4 protein CTD PMID:35357534 NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119
JBrowse link
G Prlr prolactin receptor decreases expression ISO senecionine results in decreased expression of PRLR protein CTD PMID:35357534 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prox1 prospero homeobox 1 decreases expression ISO senecionine results in decreased expression of PROX1 protein CTD PMID:35357534 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Prr12 proline rich 12 decreases expression ISO senecionine results in decreased expression of PRR12 protein CTD PMID:35357534 NCBI chr 1:95,510,015...95,534,002
Ensembl chr 1:95,509,931...95,533,652
JBrowse link
G Psap prosaposin decreases expression ISO senecionine results in decreased expression of PSAP protein CTD PMID:35357534 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498
JBrowse link
G Psip1 PC4 and SRSF1 interacting protein 1 decreases expression ISO senecionine results in decreased expression of PSIP1 protein CTD PMID:35357534 NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 increases expression ISO senecionine results in increased expression of PSMD10 protein CTD PMID:35357534 NCBI chr  X:104,656,809...104,665,122
Ensembl chr  X:104,656,812...104,665,097
JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein CTD PMID:30465738 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein CTD PMID:30465738 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO senecionine results in decreased expression of PTPRD mRNA
senecionine results in decreased expression of PTPRD protein
CTD PMID:26100227 PMID:35357534 NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
JBrowse link
G Rab11a RAB11a, member RAS oncogene family decreases expression ISO senecionine results in decreased expression of RAB11A protein CTD PMID:35357534 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO senecionine results in decreased expression of RAPGEF4 mRNA CTD PMID:26100227 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rassf1 Ras association domain family member 1 increases expression ISO senecionine results in increased expression of RASSF1 protein CTD PMID:35357534 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
JBrowse link
G Rbis ribosomal biogenesis factor decreases expression ISO senecionine results in decreased expression of RBIS protein CTD PMID:35357534 NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339
JBrowse link
G Rbm3 RNA binding motif protein 3 decreases expression ISO senecionine results in decreased expression of RBM3 protein CTD PMID:35357534 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 increases expression ISO senecionine results in increased expression of RC3H1 protein CTD PMID:35357534 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 decreases expression ISO senecionine results in decreased expression of RCL1 protein CTD PMID:35357534 NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315
JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease decreases expression ISO senecionine results in decreased expression of REXO4 protein CTD PMID:35357534 NCBI chr 3:10,280,654...10,291,003
Ensembl chr 3:10,280,654...10,290,996
JBrowse link
G Ring1 ring finger protein 1 decreases expression ISO senecionine results in decreased expression of RING1 protein CTD PMID:35357534 NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620
JBrowse link
G Rpl34 ribosomal protein L34 decreases expression ISO senecionine results in decreased expression of RPL34 protein CTD PMID:35357534 NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111
Ensembl chr17:219,284,382...219,288,111
JBrowse link
G Rpl36 ribosomal protein L36 decreases expression ISO senecionine results in decreased expression of RPL36 protein CTD PMID:35357534 NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897
JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression ISO senecionine results in increased expression of RPLP1 protein CTD PMID:35357534 NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339
JBrowse link
G Rps27 ribosomal protein S27 decreases expression ISO senecionine results in decreased expression of RPS27 protein CTD PMID:35357534 NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO senecionine results in increased expression of RRAD mRNA CTD PMID:26100227 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G RragB Ras-related GTP binding B increases expression ISO senecionine results in increased expression of RRAGB protein CTD PMID:35357534 NCBI chr  X:18,184,619...18,234,639
Ensembl chr  X:18,184,992...18,234,639
JBrowse link
G Rrbp1 ribosome binding protein 1 decreases expression ISO senecionine results in decreased expression of RRBP1 protein CTD PMID:35357534 NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 increases expression EXP senecionine results in increased expression of RRM1 mRNA CTD PMID:32419051 NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor increases expression ISO senecionine results in increased expression of RRN3 protein CTD PMID:35357534 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO senecionine results in increased expression of RSAD2 protein CTD PMID:35357534 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Rsl24d1 ribosomal L24 domain containing 1 decreases expression ISO senecionine results in decreased expression of RSL24D1 protein CTD PMID:35357534 NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO senecionine results in decreased expression of RXRA protein CTD PMID:35357534 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO senecionine results in increased expression of S100A4 protein CTD PMID:35357534 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO senecionine results in increased expression of S100A6 protein CTD PMID:35357534 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO senecionine results in increased expression of S100A9 protein CTD PMID:35357534 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Saa4 serum amyloid A4 decreases expression ISO senecionine results in decreased expression of SAA4 protein CTD PMID:35357534 NCBI chr 1:97,247,580...97,251,882 JBrowse link
G Sarnp SAP domain containing ribonucleoprotein decreases expression ISO senecionine results in decreased expression of SARNP protein CTD PMID:35357534 NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO senecionine results in increased expression of SAT1 mRNA CTD PMID:26100227 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO senecionine results in decreased expression of SCD1 protein CTD PMID:35357534 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdc2 syndecan 2 decreases expression ISO senecionine results in decreased expression of SDC2 protein CTD PMID:35357534 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Sdc4 syndecan 4 decreases expression ISO senecionine results in decreased expression of SDC4 protein CTD PMID:35357534 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 increases expression ISO senecionine results in increased expression of SDR42E1 protein CTD PMID:35357534 NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901
JBrowse link
G Secisbp2l SECIS binding protein 2-like decreases expression ISO senecionine results in decreased expression of SECISBP2L protein CTD PMID:35357534 NCBI chr 3:112,989,613...113,036,060
Ensembl chr 3:112,991,908...113,035,884
JBrowse link
G Sema3e semaphorin 3E decreases expression ISO senecionine results in decreased expression of SEMA3E protein CTD PMID:35357534 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229
JBrowse link
G Sema4b semaphorin 4B decreases expression ISO senecionine results in decreased expression of SEMA4B protein CTD PMID:35357534 NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775
JBrowse link
G Serpina10 serpin family A member 10 decreases expression ISO senecionine results in decreased expression of SERPINA10 protein CTD PMID:35357534 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
JBrowse link
G Serpina3n serpin family A member 3N decreases expression ISO senecionine results in decreased expression of SERPINA3N protein CTD PMID:35357534 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpina7 serpin family A member 7 increases expression ISO senecionine results in increased expression of SERPINA7 protein CTD PMID:35357534 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Sft2d3 SFT2 domain containing 3 increases expression ISO senecionine results in increased expression of SFT2D3 protein CTD PMID:35357534 NCBI chr18:23,537,105...23,539,305
Ensembl chr18:23,537,105...23,539,305
JBrowse link
G Sgcb sarcoglycan, beta increases expression EXP senecionine results in increased expression of SGCB mRNA CTD PMID:32419051 NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 decreases expression ISO senecionine results in decreased expression of SH3BP5 protein CTD PMID:35357534 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Sh3pxd2a SH3 and PX domains 2A decreases expression ISO senecionine results in decreased expression of SH3PXD2A protein CTD PMID:35357534 NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO
senecionine results in decreased expression of SLC10A1 mRNA CTD PMID:24641316 PMID:31606820 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a12 solute carrier family 16, member 12 decreases expression ISO senecionine results in decreased expression of SLC16A12 protein CTD PMID:35357534 NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141
JBrowse link
G Slc16a2 solute carrier family 16 member 2 increases expression ISO senecionine results in increased expression of SLC16A2 protein CTD PMID:35357534 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression ISO senecionine results in decreased expression of SLC22A1 mRNA CTD PMID:31606820 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases expression ISO senecionine results in decreased expression of SLC22A9 mRNA CTD PMID:26100227 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO senecionine results in decreased expression of SLC22A7 mRNA CTD PMID:26100227 PMID:31606820 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc25a47 solute carrier family 25, member 47 increases expression ISO senecionine results in increased expression of SLC25A47 protein CTD PMID:35357534 NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO senecionine results in increased expression of SLC2A3 protein CTD PMID:35357534 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc30a10 solute carrier family 30, member 10 decreases expression ISO senecionine results in decreased expression of SLC30A10 protein CTD PMID:35357534 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases expression ISO senecionine results in decreased expression of SLC31A2 protein CTD PMID:35357534 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
JBrowse link
G Slc38a4 solute carrier family 38, member 4 decreases expression ISO senecionine results in decreased expression of SLC38A4 protein CTD PMID:35357534 NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
JBrowse link
G Slc39a14 solute carrier family 39 member 14 decreases expression ISO senecionine results in decreased expression of SLC39A14 protein CTD PMID:35357534 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc3a1 solute carrier family 3 member 1 decreases expression ISO senecionine results in decreased expression of SLC3A1 protein CTD PMID:35357534 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Slc6a12 solute carrier family 6 member 12 decreases expression ISO senecionine results in decreased expression of SLC6A12 protein CTD PMID:35357534 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression EXP senecionine results in decreased expression of SLCO1A2 mRNA CTD PMID:24641316 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP
ISO
senecionine results in decreased expression of SLCO1B2 mRNA
senecionine results in decreased expression of SLCO1B3 mRNA
CTD PMID:24641316 PMID:26100227 PMID:31606820 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Smc2 structural maintenance of chromosomes 2 increases expression EXP senecionine results in increased expression of SMC2 mRNA CTD PMID:32419051 NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
JBrowse link
G Smc4 structural maintenance of chromosomes 4 increases expression EXP senecionine results in increased expression of SMC4 mRNA CTD PMID:32419051 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Smc6 structural maintenance of chromosomes 6 decreases expression ISO senecionine results in decreased expression of SMC6 protein CTD PMID:35357534 NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746
JBrowse link
G Smoc1 SPARC related modular calcium binding 1 decreases expression ISO senecionine results in decreased expression of SMOC1 protein CTD PMID:35357534 NCBI chr 6:100,701,330...100,897,441
Ensembl chr 6:100,701,346...100,862,699
JBrowse link
G Smpx small muscle protein, X-linked decreases expression EXP senecionine results in decreased expression of SMPX mRNA CTD PMID:34185104 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 decreases expression ISO senecionine results in decreased expression of SND1 protein CTD PMID:35357534 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
JBrowse link
G Soat1 sterol O-acyltransferase 1 decreases expression ISO senecionine results in decreased expression of SOAT1 protein CTD PMID:35357534 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
G Sqle squalene epoxidase decreases expression ISO senecionine results in decreased expression of SQLE protein CTD PMID:35357534 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO senecionine results in decreased expression of SREBF1 protein CTD PMID:35357534 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Sri sorcin increases expression ISO senecionine results in increased expression of SRI protein CTD PMID:35357534 NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
JBrowse link
G Srl sarcalumenin decreases expression EXP senecionine results in decreased expression of SRL mRNA CTD PMID:34185104 NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP senecionine results in decreased expression of STAC3 mRNA CTD PMID:32419051 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
JBrowse link
G Stc1 stanniocalcin 1 increases expression EXP senecionine results in increased expression of STC1 mRNA CTD PMID:34185104 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Steap4 STEAP4 metalloreductase increases expression
decreases expression
EXP
ISO
senecionine results in increased expression of STEAP4 mRNA
senecionine results in decreased expression of STEAP4 protein
CTD PMID:34185104 PMID:35357534 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Stil STIL, centriolar assembly protein increases expression EXP senecionine results in increased expression of STIL mRNA CTD PMID:32419051 NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
JBrowse link
G Stmn1 stathmin 1 increases expression EXP senecionine results in increased expression of STMN1 mRNA CTD PMID:32419051 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Ston1 stonin 1 increases expression ISO senecionine results in increased expression of STON1 protein CTD PMID:35357534 NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression ISO senecionine results in increased expression of SUCLG2 protein CTD PMID:35357534 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO senecionine results in decreased expression of SULT1E1 mRNA CTD PMID:26100227 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO senecionine results in decreased expression of SULT2A1 mRNA CTD PMID:31606820 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
G Surf2 surfeit 2 increases expression ISO senecionine results in increased expression of SURF2 protein CTD PMID:35357534 NCBI chr 3:10,244,654...10,248,502
Ensembl chr 3:10,244,654...10,250,077
JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor decreases expression ISO senecionine results in decreased expression of SYF2 protein CTD PMID:35357534 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
JBrowse link
G Tcf19 transcription factor 19 increases expression EXP senecionine results in increased expression of TCF19 mRNA CTD PMID:32419051 NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271
JBrowse link
G Tdrd1 tudor domain containing 1 increases expression ISO senecionine results in increased expression of TDRD1 protein CTD PMID:35357534 NCBI chr 1:255,871,939...255,919,222
Ensembl chr 1:255,875,887...255,915,871
JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 increases expression ISO senecionine results in increased expression of TECPR1 protein CTD PMID:35357534 NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611
JBrowse link
G Tenm1 teneurin transmembrane protein 1 decreases expression ISO senecionine results in decreased expression of TENM1 mRNA CTD PMID:26100227 NCBI chr  X:121,400,466...122,289,877
Ensembl chr  X:121,403,649...122,290,207
JBrowse link
G Tenm2 teneurin transmembrane protein 2 decreases expression ISO senecionine results in decreased expression of TENM2 mRNA CTD PMID:26100227 NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO senecionine results in increased expression of TGFB1 mRNA; senecionine results in increased expression of TGFB1 protein CTD PMID:35357534 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression
multiple interactions
ISO senecionine results in increased expression of THBS1 mRNA; senecionine results in increased expression of THBS1 protein
Leu-Ser-Lys-Leu peptide inhibits the reaction [senecionine results in increased expression of THBS1 mRNA]; senecionine promotes the reaction [Pyrrolizidine Alkaloids binds to THBS1 protein]
CTD PMID:35357534 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tlr8 toll-like receptor 8 increases expression EXP senecionine results in increased expression of TLR8 mRNA CTD PMID:34185104 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tma7 translation machinery associated 7 homolog decreases expression ISO senecionine results in decreased expression of TMA7 protein CTD PMID:35357534 NCBI chr 8:109,726,213...109,730,902
Ensembl chr 8:109,726,196...109,735,474
JBrowse link
G Tmem144 transmembrane protein 144 increases expression ISO senecionine results in increased expression of TMEM144 protein CTD PMID:35357534 NCBI chr 2:164,960,649...164,993,562
Ensembl chr 2:164,961,247...164,992,368
JBrowse link
G Tmem176a transmembrane protein 176A decreases expression ISO senecionine results in decreased expression of TMEM176A protein CTD PMID:35357534 NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
JBrowse link
G Tmem176b transmembrane protein 176B decreases expression ISO senecionine results in decreased expression of TMEM176B protein CTD PMID:35357534 NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
JBrowse link
G Tmem208 transmembrane protein 208 decreases expression ISO senecionine results in decreased expression of TMEM208 protein CTD PMID:35357534 NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
JBrowse link
G Tmem35b transmembrane protein 35B increases expression ISO senecionine results in increased expression of TMEM35B protein CTD PMID:35357534 NCBI chr 5:139,446,317...139,449,947
Ensembl chr 5:139,444,399...139,449,947
JBrowse link
G Tmem87b transmembrane protein 87B decreases expression ISO senecionine results in decreased expression of TMEM87B protein CTD PMID:35357534 NCBI chr 3:116,061,933...116,097,421
Ensembl chr 3:116,062,204...116,097,367
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression EXP senecionine results in increased expression of TNFRSF1B mRNA CTD PMID:34185104 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 decreases expression ISO senecionine results in decreased expression of TNIP2 protein CTD PMID:35357534 NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265
JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type decreases expression EXP senecionine results in decreased expression of TNNC1 mRNA CTD PMID:34185104 NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634
JBrowse link
G Top2a DNA topoisomerase II alpha increases expression EXP senecionine results in increased expression of TOP2A mRNA CTD PMID:32419051 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase decreases expression ISO senecionine results in decreased expression of TOPORS protein CTD PMID:35357534 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937
JBrowse link
G Tox thymocyte selection-associated high mobility group box decreases expression ISO senecionine results in decreased expression of TOX protein CTD PMID:35357534 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
G Tp53 tumor protein p53 increases expression ISO senecionine results in increased expression of TRP53 mRNA; senecionine results in increased expression of TRP53 protein
senecionine results in increased expression of TP53 mRNA
CTD PMID:35357534 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpmt thiopurine S-methyltransferase increases expression ISO senecionine results in increased expression of TPMT mRNA CTD PMID:26100227 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tpx2 TPX2, microtubule nucleation factor increases expression EXP senecionine results in increased expression of TPX2 mRNA CTD PMID:32419051 NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
JBrowse link
G Treml1 triggering receptor expressed on myeloid cells-like 1 increases expression ISO senecionine results in increased expression of TREML1 protein CTD PMID:35357534 NCBI chr 9:12,635,584...12,642,324
Ensembl chr 9:12,635,590...12,642,347
JBrowse link
G Tsr2 TSR2, ribosome maturation factor decreases expression ISO senecionine results in decreased expression of TSR2 protein CTD PMID:35357534 NCBI chr  X:20,064,102...20,072,673
Ensembl chr  X:20,064,103...20,072,620
JBrowse link
G Tstd3 thiosulfate sulfurtransferase like domain containing 3 increases expression ISO senecionine results in increased expression of TSTD3 protein CTD PMID:35357534 NCBI chr 5:35,294,652...35,304,093
Ensembl chr 5:35,294,645...35,304,101
JBrowse link
G Ttk Ttk protein kinase increases expression EXP senecionine results in increased expression of TTK mRNA CTD PMID:32419051 NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
JBrowse link
G Ttr transthyretin decreases expression ISO senecionine results in decreased expression of TTR protein CTD PMID:35357534 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Tuft1 tuftelin 1 increases expression ISO senecionine results in increased expression of TUFT1 protein CTD PMID:35357534 NCBI chr 2:182,259,457...182,306,296
Ensembl chr 2:182,260,398...182,306,192
JBrowse link
G Tyms thymidylate synthetase increases expression EXP senecionine results in increased expression of TYMS mRNA CTD PMID:32419051 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ubl3 ubiquitin-like 3 decreases expression ISO senecionine results in decreased expression of UBL3 protein CTD PMID:35357534 NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862
JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 increases expression ISO senecionine results in increased expression of UCHL3 mRNA CTD PMID:26100227 NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355
Ensembl chr 3:78,485,315...78,527,355
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 increases expression ISO senecionine results in increased expression of UCKL1 protein CTD PMID:35357534 NCBI chr 3:168,674,849...168,687,513
Ensembl chr 3:168,674,849...168,698,091
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glycosylation
multiple interactions
ISO UGT1A4 protein results in increased glycosylation of senecionine
[hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine
CTD PMID:20092275 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO senecionine results in decreased expression of UGT2A3 mRNA CTD PMID:26100227 NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression ISO senecionine results in decreased expression of UGT2B1 mRNA CTD PMID:31606820 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Utp11 UTP11, small subunit processome component decreases expression ISO senecionine results in decreased expression of UTP11 protein CTD PMID:35357534 NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191
JBrowse link
G Vps13b vacuolar protein sorting 13 homolog B decreases expression ISO senecionine results in decreased expression of VPS13B mRNA CTD PMID:26100227 NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429
JBrowse link
G Vps36 vacuolar protein sorting 36 homolog increases expression ISO senecionine results in increased expression of VPS36 protein CTD PMID:35357534 NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810
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G Wdr53 WD repeat domain 53 decreases expression ISO senecionine results in decreased expression of WDR53 protein CTD PMID:35357534 NCBI chr11:68,542,647...68,551,148
Ensembl chr11:68,542,650...68,551,112
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G Wdr82 WD repeat domain 82 decreases expression ISO senecionine results in decreased expression of WDR82 protein CTD PMID:35357534 NCBI chr 8:106,814,569...106,834,535
Ensembl chr 8:106,814,569...106,834,438
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G Xpa XPA, DNA damage recognition and repair factor increases expression ISO senecionine results in increased expression of XPA protein CTD PMID:35357534 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
JBrowse link
G Xylt2 xylosyltransferase 2 decreases expression ISO senecionine results in decreased expression of XYLT2 protein CTD PMID:35357534 NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391
JBrowse link
G Yipf5 Yip1 domain family, member 5 decreases expression ISO senecionine results in decreased expression of YIPF5 protein CTD PMID:35357534 NCBI chr18:32,123,814...32,136,947
Ensembl chr18:32,123,842...32,157,642
JBrowse link
G Zcchc10 zinc finger CCHC-type containing 10 increases expression ISO senecionine results in increased expression of ZCCHC10 protein CTD PMID:35357534 NCBI chr10:37,470,628...37,481,027 JBrowse link
G Zfp106 zinc finger protein 106 increases expression ISO senecionine results in increased expression of ZNF106 protein CTD PMID:35357534 NCBI chr 3:107,459,232...107,510,507
Ensembl chr 3:107,462,096...107,510,481
JBrowse link
G Zfp367 zinc finger protein 367 increases expression EXP senecionine results in increased expression of ZFP367 mRNA CTD PMID:32419051 NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 increases expression ISO senecionine results in increased expression of ZFP36L1 protein CTD PMID:35357534 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
JBrowse link
G Zg16 zymogen granule protein 16 decreases expression ISO senecionine results in decreased expression of ZG16 protein CTD PMID:35357534 NCBI chr 1:181,657,722...181,660,079
Ensembl chr 1:181,657,722...181,660,079
JBrowse link
G Zwilch zwilch kinetochore protein increases expression EXP senecionine results in increased expression of ZWILCH mRNA CTD PMID:32419051 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            alkaloid 8016
              pyrrolizine alkaloid 629
                senecionan 629
                  erucifoline + 1
                  riddelliine + 138
                  senecionine + 511
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      pyrrolizines 829
                                        pyrrolizine alkaloid 629
                                          senecionan 629
                                            erucifoline + 1
                                            riddelliine + 138
                                            senecionine + 511
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