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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxo dicarboxylic acid
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Accession:CHEBI:36145 term browser browse the term
Definition:Any dicarboxylic acid carrying one or more oxo groups.
Synonyms:related_synonym: oxo dicarboxylic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:133294


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2-oxoadipic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of alpha-ketoadipic acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
decreases abundance		 ISO PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Oxaloacetic Acid] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      chemical role 19479
        donor 18928
          Bronsted acid 18808
            oxoacid 18782
              carbon oxoacid 18658
                carboxylic acid 18655
                  oxo carboxylic acid 6317
                    oxo dicarboxylic acid 10
                      (2E,4Z)-4-Hydroxy-6-oxo-2,4-octadienedioic acid 0
                      (2S)-2-isopropyl-3-oxosuccinic acid 0
                      (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                      (2Z,4E)-4-hydroxy-6-oxoocta-2,4-dienedioic acid 0
                      (4Z)-2-oxohept-4-enedioic acid 0
                      (S)-2-acetamido-6-oxopimelic acid 0
                      (S)-2-amino-6-oxopimelic acid + 0
                      (Z)-5-oxohex-2-enedioic acid 0
                      (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                      (oxaloamino)benzoic acid + 0
                      13,14-dihydro-15-oxo-20-carboxy-PGF2alpha 0
                      2,3,4,5-tetranor-prostaglandin FM 0
                      2,3,5-trichloromaleylacetic acid 0
                      2,4-dichloro-3-oxoadipic acid 0
                      2,4-dioxopentanedioic acid 0
                      2,5-dichloro-4-oxohex-2-enedioic acid 0
                      2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                      2-amino-3-oxoadipic acid 0
                      2-chloro-3-oxoadipic acid 0
                      2-chloromaleylacetic acid 0
                      2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid 0
                      2-hydroxy-3-carboxybenzylidenepyruvic acid 0
                      2-hydroxy-3-oxoadipic acid 0
                      2-hydroxy-3-oxosuccinic acid + 0
                      2-oxoadipic acid 1
                      2-oxoglutaric acid + 0
                      2-oxohept-4-ene-1,7-dioic acid 0
                      2-oxohex-3-enedioic acid + 0
                      2-oxopimelic acid 0
                      2-oxosuberic acid 0
                      3-oxalobenzoic acid 0
                      3-oxoadipic acid + 0
                      3-oxopimelic acid + 0
                      4,6-dioxohept-2-enedioic acid + 0
                      4-fumarylacetoacetic acid 0
                      4-hydroxy-2-oxoglutaric acid + 0
                      4-hydroxy-2-oxoheptanedioic acid + 0
                      4-hydroxy-4-methyl-2-oxoadipic acid 0
                      4-hydroxy-4-methyl-2-oxoglutaric acid 0
                      4-maleylacetoacetic acid 0
                      4-nitro-6-oxohepta-2,4-dienedioic acid 0
                      4-oxohex-2-enedioic acid + 0
                      5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                      5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                      5-dehydro-4-deoxy-D-glucaric acid 0
                      D-prephenyl lactate 0
                      N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine 0
                      dinoflagellate luciferin 0
                      dioxosuccinic acid 0
                      glycyrrhetic acid 3-O-glucuronide 0
                      ixazomib citrate 0
                      laccaic acid A + 0
                      laccaic acid B + 0
                      oxaloacetic acid + 9
                      oxidized dinoflagellate luciferin 0
                      oxomalonic acid 0
                      prephenic acid + 0
                      prostaglandin E2-UM 0
                      sennoside A + 0
                      sennoside B + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      oxo carboxylic acid 6317
                                        oxo dicarboxylic acid 10
                                          (2E,4Z)-4-Hydroxy-6-oxo-2,4-octadienedioic acid 0
                                          (2S)-2-isopropyl-3-oxosuccinic acid 0
                                          (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                                          (2Z,4E)-4-hydroxy-6-oxoocta-2,4-dienedioic acid 0
                                          (4Z)-2-oxohept-4-enedioic acid 0
                                          (S)-2-acetamido-6-oxopimelic acid 0
                                          (S)-2-amino-6-oxopimelic acid + 0
                                          (Z)-5-oxohex-2-enedioic acid 0
                                          (Z)-6-amino-2-hydroxy-4-(2-oxovinyl)hept-3-enedioic acid 0
                                          (oxaloamino)benzoic acid + 0
                                          13,14-dihydro-15-oxo-20-carboxy-PGF2alpha 0
                                          2,3,4,5-tetranor-prostaglandin FM 0
                                          2,3,5-trichloromaleylacetic acid 0
                                          2,4-dichloro-3-oxoadipic acid 0
                                          2,4-dioxopentanedioic acid 0
                                          2,5-dichloro-4-oxohex-2-enedioic acid 0
                                          2-amino-3-(3-oxoprop-1-enyl)but-2-enedioic acid + 0
                                          2-amino-3-oxoadipic acid 0
                                          2-chloro-3-oxoadipic acid 0
                                          2-chloromaleylacetic acid 0
                                          2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoic acid 0
                                          2-hydroxy-3-carboxybenzylidenepyruvic acid 0
                                          2-hydroxy-3-oxoadipic acid 0
                                          2-hydroxy-3-oxosuccinic acid + 0
                                          2-oxoadipic acid 1
                                          2-oxoglutaric acid + 0
                                          2-oxohept-4-ene-1,7-dioic acid 0
                                          2-oxohex-3-enedioic acid + 0
                                          2-oxopimelic acid 0
                                          2-oxosuberic acid 0
                                          3-oxalobenzoic acid 0
                                          3-oxoadipic acid + 0
                                          3-oxopimelic acid + 0
                                          4,6-dioxohept-2-enedioic acid + 0
                                          4-fumarylacetoacetic acid 0
                                          4-hydroxy-2-oxoglutaric acid + 0
                                          4-hydroxy-2-oxoheptanedioic acid + 0
                                          4-hydroxy-4-methyl-2-oxoadipic acid 0
                                          4-hydroxy-4-methyl-2-oxoglutaric acid 0
                                          4-maleylacetoacetic acid 0
                                          4-nitro-6-oxohepta-2,4-dienedioic acid 0
                                          4-oxohex-2-enedioic acid + 0
                                          5-(2'-carboxyethyl)-4,6-dihydroxypicolinic acid 0
                                          5-(3'-carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinic acid 0
                                          5-(3'-carboxy-3'-oxopropyl)-4,6-dihydroxypicolinic acid 0
                                          5-dehydro-4-deoxy-D-glucaric acid 0
                                          D-prephenyl lactate 0
                                          N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine 0
                                          dinoflagellate luciferin 0
                                          dioxosuccinic acid 0
                                          glycyrrhetic acid 3-O-glucuronide 0
                                          ixazomib citrate 0
                                          laccaic acid A + 0
                                          laccaic acid B + 0
                                          oxaloacetic acid + 9
                                          oxidized dinoflagellate luciferin 0
                                          oxomalonic acid 0
                                          prephenic acid + 0
                                          prostaglandin E2-UM 0
                                          sennoside A + 0
                                          sennoside B + 0
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