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G |
Glud1 |
glutamate dehydrogenase 1 |
multiple interactions decreases activity |
ISO |
dipicolinic acid inhibits the reaction [[GLUD1 protein co-treated with Ketoglutaric Acids co-treated with NADP co-treated with Aminooxyacetic Acid] affects the reaction [Carbon Tetrachloride affects the abundance of Ammonia]] dipicolinic acid results in decreased activity of GLUD1 protein |
CTD |
PMID:26639393 |
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NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
dipicolinic acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
affects abundance |
EXP |
ACMSD protein affects the abundance of Quinolinic Acid |
CTD |
PMID:17896587 |
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NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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G |
Ahr |
aryl hydrocarbon receptor |
increases activity |
ISO |
Quinolinic Acid results in increased activity of AHR protein |
CTD |
PMID:28336214 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
Quinolinic Acid results in increased expression of BAX mRNA [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP |
Quinolinic Acid results in decreased expression of BCL2 mRNA [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA] |
CTD |
PMID:30130594 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
increases expression |
EXP |
Quinolinic Acid results in increased expression of BDNF mRNA |
CTD |
PMID:15698628 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Casp3 |
caspase 3 |
increases expression increases activity multiple interactions |
EXP |
Quinolinic Acid results in increased expression of CASP3 mRNA Quinolinic Acid results in increased activity of CASP3 protein [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein] |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions decreases activity decreases expression |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]]; nimesulide inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]; pioglitazone inhibits the reaction [Quinolinic Acid results in decreased activity of CAT protein]; rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] |
CTD |
PMID:20043943 PMID:20450929 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Chat |
choline O-acetyltransferase |
multiple interactions decreases activity |
EXP |
Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] |
CTD |
PMID:2976130 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Cp |
ceruloplasmin |
multiple interactions |
EXP |
[Copper Sulfate co-treated with Quinolinic Acid] results in increased activity of CP protein |
CTD |
PMID:12899943 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Dpp3 |
dipeptidylpeptidase 3 |
multiple interactions |
EXP |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
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G |
Drd1 |
dopamine receptor D1 |
decreases expression |
EXP |
Quinolinic Acid results in decreased expression of DRD1 protein |
CTD |
PMID:12207953 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
increases expression |
EXP |
Quinolinic Acid results in increased expression of DRD2 protein |
CTD |
PMID:12207953 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
EXP |
GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein]; Quinolinic Acid results in increased expression of and results in increased cleavage of EIF2AK2 protein |
CTD |
PMID:24211709 |
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NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation multiple interactions |
EXP |
Quinolinic Acid results in increased phosphorylation of EIF2S1 protein [Quinolinic Acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:24211709 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Fgf1 |
fibroblast growth factor 1 |
decreases secretion |
ISO |
Quinolinic Acid results in decreased secretion of FGF1 protein |
CTD |
PMID:16392031 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Quinolinic Acid results in increased expression of FOS mRNA |
CTD |
PMID:15698628 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity |
EXP |
Quinolinic Acid results in increased activity of G6PD protein |
CTD |
PMID:30876764 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions |
EXP |
Quinolinic Acid results in increased expression of IL1B mRNA; Quinolinic Acid results in increased expression of IL1B protein [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; GW 506033X inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein] |
CTD |
PMID:24211709 PMID:29981346 PMID:30130594 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; wedelolactone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein] Quinolinic Acid results in increased expression of IL6 mRNA; Quinolinic Acid results in increased expression of IL6 protein |
CTD |
PMID:29981346 PMID:30130594 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
Quinolinic Acid promotes the reaction [DPP3 protein binds to KEAP1 protein]; Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein]; Quinolinic Acid results in increased expression of and affects the localization of KEAP1 protein |
CTD |
PMID:30876764 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Quinolinic Acid promotes the reaction [MAPT protein binds to MAPT protein] |
CTD |
PMID:31678113 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Quinolinic Acid results in increased activity of and affects the localization of NFE2L2 protein |
CTD |
PMID:30876764 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions decreases expression |
EXP |
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA] |
CTD |
PMID:30130594 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppif |
peptidylprolyl isomerase F |
increases response to substance |
ISO |
PPIF results in increased susceptibility to Quinolinic Acid |
CTD |
PMID:21378209 |
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NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
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G |
Rgs2 |
regulator of G-protein signaling 2 |
decreases expression |
EXP |
Quinolinic Acid results in decreased expression of RGS2 mRNA; Quinolinic Acid results in decreased expression of RGS2 protein |
CTD |
PMID:12207953 |
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NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Slc6a3 |
solute carrier family 6 member 3 |
decreases expression increases expression |
EXP |
Quinolinic Acid results in decreased expression of SLC6A3 protein Quinolinic Acid results in increased expression of SLC6A3 protein |
CTD |
PMID:12207953 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Sod1 |
superoxide dismutase 1 |
decreases activity multiple interactions |
EXP |
Quinolinic Acid results in decreased activity of SOD1 protein Copper Sulfate inhibits the reaction [Quinolinic Acid results in decreased activity of SOD1 protein] |
CTD |
PMID:12899943 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sqstm1 |
sequestosome 1 |
multiple interactions |
EXP |
Quinolinic Acid promotes the reaction [SQSTM1 protein binds to KEAP1 protein] |
CTD |
PMID:30876764 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of TNF protein] Quinolinic Acid results in increased expression of TNF mRNA; Quinolinic Acid results in increased expression of TNF protein |
CTD |
PMID:20450929 PMID:30130594 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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