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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-naphthoic acid
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Accession:CHEBI:36106 term browser browse the term
Definition:A naphthoic acid that is naphthalene carrying a carboxy group at position 2.
Synonyms:related_synonym: 2-naphthalenecarboxylic acid;   Formula=C11H8O2;   InChI=1S/C11H8O2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,12,13);   InChIKey=UOBYKYZJUGYBDK-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2ccccc2c1;   beta-naphthoic acid;   isonaphthoic acid;   naphthalene-2-carboxylic acid
 alt_id: CHEBI:19725;   CHEBI:30900;   CHEBI:34299
 xref: Beilstein:972039;   CAS:93-09-4;   Gmelin:185326;   KEGG:C14101;   PMID:19005807;   PMID:19712381;   Reaxys:972039
 cyclic_relationship: is_conjugate_acid_of CHEBI:36107


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1,4-dihydroxy-2-naphthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:27837168 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
1-hydroxy-2-naphthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:27837168 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:21667204 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] CTD PMID:21667204 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:21667204 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:21667204 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:21667204 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIA protein] CTD PMID:21667204 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:21667204 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:21667204 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] CTD PMID:21667204 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
pamoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions
affects localization		 ISO 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [pamoic acid affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [pamoic acid binds to and results in increased activity of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [pamoic acid affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [pamoic acid binds to and results in increased activity of GPR35 protein]; pamoic acid binds to and results in increased activity of GPR35 protein; pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 PMID:20919992 PMID:22967846 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:20826425 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20826425 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          metabolite 19562
            xenobiotic metabolite 16176
              2-naphthoic acid 14
                1,4-dihydroxy-2-naphthoic acid + 4
                1-hydroxy-2-naphthoic acid 12
                2-naphthoyl group + 0
                2-naphthoyl-CoA 0
                6-dimethylamino-2-naphthoic acid + 0
                pamoic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                carbocyclic compound 18607
                                  carbopolycyclic compound 17189
                                    carbobicyclic compound 5885
                                      naphthalenes 3849
                                        naphthoic acid 44
                                          2-naphthoic acid 14
                                            1,4-dihydroxy-2-naphthoic acid + 4
                                            1-hydroxy-2-naphthoic acid 12
                                            2-naphthoyl group + 0
                                            2-naphthoyl-CoA 0
                                            6-dimethylamino-2-naphthoic acid + 0
                                            pamoic acid 4
paths to the root