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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxytocic
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Accession:CHEBI:36063 term browser browse the term
Definition:A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients).
Synonyms:related_synonym: oxytocic agents;   oxytocic drugs;   uterine stimulants


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ergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] CTD PMID:19121572 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ergotamine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:19121572 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions ISO Ergotamine binds to and results in increased activity of HTR2B protein CTD PMID:11104741 NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:94,190,109...94,204,087 		JBrowse link
misoprostol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:18602972 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:18602972 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase multiple interactions EXP Misoprostol inhibits the reaction [Cisplatin results in decreased expression of CAT protein] CTD PMID:21458517 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Misoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein] CTD PMID:2459756 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602 		JBrowse link
G Gast gastrin multiple interactions
decreases activity 		EXP Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]
Misoprostol results in decreased activity of GAST protein 		CTD PMID:2459756 PMID:11164953 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions
increases expression 		ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]
Misoprostol results in increased expression of IL23A mRNA 		CTD PMID:19273625 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO [L-335677 binds to and results in decreased activity of PTGER1 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr19:41,374,983...41,379,593
Ensembl chr19:41,374,471...41,378,284 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions ISO [L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression 		EXP 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein] CTD PMID:12428691 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Misoprostol promotes the reaction [Kallidin results in increased secretion of TAC1 protein] CTD PMID:16039053 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Misoprostol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
oxytocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression EXP Oxytocin results in increased expression of BCL2 protein CTD PMID:23707249 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP Oxytocin results in increased expression of EGFR protein modified form CTD PMID:23707249 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions 		EXP Oxytocin results in increased expression of FOS protein
Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein] 		CTD PMID:20731630 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gdf9 growth differentiation factor 9 increases expression EXP Oxytocin results in increased expression of GDF9 protein CTD PMID:23707249 NCBI chr10:38,090,021...38,100,801
Ensembl chr10:38,089,878...38,100,797 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Oxytocin results in increased expression of HAS2 protein CTD PMID:23707249 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression 		ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]
Oxytocin results in increased expression of KLF4 mRNA; Oxytocin results in increased expression of KLF4 protein 		CTD PMID:29104011 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions ISO MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP Oxytocin results in increased expression of MAPK1 protein modified form CTD PMID:23707249 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression EXP Oxytocin results in increased expression of MAPK3 protein modified form CTD PMID:23707249 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]; MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of MKNK2 mRNA] CTD PMID:21993003 NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,690,421...9,701,529 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases response to substance EXP MMP2 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance EXP MMP9 protein results in decreased susceptibility to Oxytocin CTD PMID:22496348 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP Oxytocin inhibits the reaction [Cisplatin results in increased expression of NOXO1 mRNA] CTD PMID:21993003 NCBI chr10:14,226,473...14,230,541
Ensembl chr10:14,228,205...14,230,541 		JBrowse link
G Oxtr oxytocin receptor multiple interactions
increases expression 		EXP
ISO 		Oxytocin analog binds to and results in decreased activity of OXTR protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of OXTR protein] 		CTD PMID:9502799 PMID:27340106 NCBI chr 4:147,154,374...147,171,723
Ensembl chr 4:147,154,374...147,170,750 		JBrowse link
G Plcb1 phospholipase C beta 1 affects localization ISO Oxytocin affects the localization of PLCB1 protein CTD PMID:11579162 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Plcb3 phospholipase C beta 3 affects localization ISO Oxytocin affects the localization of PLCB3 protein CTD PMID:11579162 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		EXP
ISO 		Oxytocin results in increased expression of PTGS2 protein
guizhi-fuling inhibits the reaction [Oxytocin results in increased expression of PTGS2 protein] 		CTD PMID:23707249 PMID:27340106 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Sele selectin E multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein] CTD PMID:29104011 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression EXP Oxytocin results in increased expression of TNFAIP6 protein CTD PMID:23707249 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 mRNA]; Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein] CTD PMID:29104011 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases export
affects export 		ISO ABCC4 protein results in increased export of Dinoprostone
ABCC4 gene SNP affects the export of Dinoprostone 		CTD PMID:22155354 PMID:27659809 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone] CTD PMID:14738173 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
decreases expression 		EXP 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Dinoprostone results in decreased expression of ACTA1 mRNA] CTD PMID:18030065 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:68,781,168...68,786,178 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Dinoprostone results in increased expression of ACTA2 protein CTD PMID:27697457 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Dinoprostone inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:120,550,328...120,556,383 		JBrowse link
G Adm adrenomedullin decreases expression ISO Dinoprostone results in decreased expression of ADM mRNA CTD PMID:19253104 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone] CTD PMID:17369603 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803 		JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance 		EXP Dexamethasone inhibits the reaction [AGT protein alternative form results in increased abundance of Dinoprostone] CTD PMID:4030047 PMID:6421564 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone] CTD PMID:21334316 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
multiple interactions 		ISO
EXP 		Dinoprostone results in increased phosphorylation of AKT1 protein
Dinoprostone results in decreased phosphorylation of AKT1 protein
taiwanin C inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]
Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of AKT1 protein]
Dinoprostone results in increased phosphorylation of and results in increased activity of AKT1 protein; oxodiperoxo(pyridine-2-carboxylate)vanadate(V) inhibits the reaction [Dinoprostone results in decreased phosphorylation of AKT1 protein] 		CTD PMID:16396944 PMID:17805209 PMID:18056380 PMID:23747687 PMID:25094029 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of Dinoprostone CTD PMID:21193584 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Anxa1 annexin A1 multiple interactions ISO ANXA1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone] CTD PMID:21777521 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions EXP Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of APOA1 mRNA] CTD PMID:15816358 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G App amyloid beta precursor protein increases abundance
multiple interactions
increases secretion
increases expression 		EXP
ISO 		APP protein modified form results in increased abundance of Dinoprostone
CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; Dronabinol inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; L 685458 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]
[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone]
PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone]; resveratrol inhibits the reaction [APP protein results in increased secretion of Dinoprostone]
Dinoprostone results in increased expression of APP protein modified form 		CTD PMID:16685418 PMID:20171164 PMID:23261590 PMID:28721267 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Aqp1 aquaporin 1 increases response to substance ISO AQP1 results in increased susceptibility to Dinoprostone CTD PMID:20018876 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions 		ISO
EXP 		Dinoprostone results in increased expression of AREG mRNA; Dinoprostone results in increased expression of AREG protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]; U 0126 inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA] 		CTD PMID:15284208 PMID:15509566 PMID:16888076 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions
increases phosphorylation 		ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] CTD PMID:12164941 PMID:22188298 NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Dinoprostone results in decreased expression of SIRT1 mRNA]; ATF3 protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Dinoprostone promotes the reaction [ATF3 protein binds to SIRT1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of ATF3 protein] 		CTD PMID:30409902 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions 		EXP AVP protein results in increased abundance of Dinoprostone
Dexamethasone inhibits the reaction [AVP protein results in increased abundance of Dinoprostone] 		CTD PMID:4030047 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]] CTD PMID:25432964 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP 		[BAX binds to Dinoprostone] which results in increased localization of BAX
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BAX protein] 		CTD PMID:16396944 PMID:17369862 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of BCL2 protein
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]] 		CTD PMID:9443418 PMID:25432964 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Dinoprostone affects the reaction [Puromycin Aminonucleoside results in decreased expression of BCL2L1 protein] CTD PMID:16396944 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Dinoprostone results in increased expression of BIRC3 protein CTD PMID:12837940 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein] CTD PMID:21268125 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP [KNG1 protein co-treated with Dinoprostone] results in increased secretion of CALCA protein; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Histamine results in increased secretion of CALCA protein]]; Dinoprostone inhibits the reaction [Flurbiprofen inhibits the reaction [Serotonin results in increased secretion of CALCA protein]]; Dinoprostone promotes the reaction [Capsaicin results in increased secretion of CALCA protein]; Dinoprostone promotes the reaction [Protons results in increased secretion of CALCA protein] CTD PMID:11166334 PMID:12044622 PMID:14991081 PMID:18296611 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions 		ISO
EXP 		Dinoprostone results in decreased activity of CASP3 protein
Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]
Dinoprostone inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] 		CTD PMID:12837940 PMID:16396944 PMID:20335659 PMID:25094029 PMID:25432964 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]] CTD PMID:25432964 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein] CTD PMID:25094029 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
decreases abundance 		EXP
ISO 		CAT protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [CAT protein results in decreased abundance of Dinoprostone] 		CTD PMID:10899936 PMID:11286988 PMID:25432964 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbs cystathionine beta synthase multiple interactions ISO CBS protein inhibits the reaction [Rotenone results in increased abundance of Dinoprostone] CTD PMID:25086357 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of CCL12 mRNA] CTD PMID:28434932 NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,567,876...67,569,426 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Dinoprostone results in increased expression of CCL17 mRNA CTD PMID:16303787 NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression 		ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]
Dinoprostone results in decreased expression of CCL2 mRNA 		CTD PMID:16303787 PMID:16784723 PMID:21913898 PMID:25432964 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO [Dinoprostone co-treated with IL1B] results in increased expression of CCL20; Dinoprostone promotes the reaction [IL23A results in increased expression of CCL20]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein] 		CTD PMID:17667525 PMID:19273625 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO Dinoprostone results in increased expression of CCL22 mRNA CTD PMID:16303787 NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] CTD PMID:16784723 NCBI chr 5:61,737,261...61,744,375
Ensembl chr 5:61,737,261...61,743,522 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression 		ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]
Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]
Dinoprostone results in decreased expression of CCL3 mRNA 		CTD PMID:9863660 PMID:16303787 PMID:17667525 PMID:21913898 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression
multiple interactions 		ISO Dinoprostone results in decreased expression of CCL4 protein
Dinoprostone results in decreased expression of CCL4 mRNA
Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]] 		CTD PMID:16303787 PMID:17667525 PMID:21913898 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
multiple interactions 		ISO Dinoprostone results in decreased expression of CCL5 mRNA
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] 		CTD PMID:10495789 PMID:16303787 PMID:16784723 PMID:17667525 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA] CTD PMID:28434932 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression 		ISO taiwanin C inhibits the reaction [Dinoprostone results in increased expression of CCND1 protein] CTD PMID:30884126 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO Dinoprostone results in decreased expression of CCR5 mRNA; Dinoprostone results in decreased expression of CCR5 protein CTD PMID:16303787 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 multiple interactions ISO [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6 CTD PMID:19273625 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:55,021,833...55,046,059 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of CCR7 mRNA; Dinoprostone results in increased expression of CCR7 protein
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein 		CTD PMID:16303787 PMID:18952292 NCBI chr10:84,594,399...84,604,514
Ensembl chr10:84,593,594...84,604,501 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of CD68 protein] CTD PMID:25432964 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540 		JBrowse link
G Cdh1 cadherin 1 decreases expression
multiple interactions 		ISO Dinoprostone results in decreased expression of CDH1 protein
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] 		CTD PMID:30208247 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]] CTD PMID:25432964 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions
increases secretion 		EXP
ISO 		bifenthrin analog inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; bifenthrin inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]
butylbenzyl phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; Dibutyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone]; Diethylhexyl Phthalate inhibits the reaction [CGA protein results in increased secretion of Dinoprostone] 		CTD PMID:21251947 PMID:21871944 PMID:25016925 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO Dinoprostone results in increased expression of COL10A1 mRNA; Dinoprostone results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr20:39,737,536...39,744,518
Ensembl chr20:39,716,822...39,751,440 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO Dinoprostone results in decreased expression of COL1A1 mRNA CTD PMID:8971655 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression
multiple interactions 		ISO
EXP 		Dinoprostone results in increased expression of COL2A1 mRNA; Dinoprostone results in increased expression of COL2A1 protein
Indomethacin inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone] 		CTD PMID:27050768 PMID:35446470 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cp ceruloplasmin increases secretion EXP CP protein results in increased secretion of Dinoprostone CTD PMID:17727827 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation 		ISO [nickel sulfate co-treated with Dinoprostone] results in increased expression of CREB1 protein; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; CREB1 protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein] CTD PMID:12164941 PMID:23526216 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Dinoprostone promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; Dinoprostone promotes the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:9066782 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein 		CTD PMID:15180965 PMID:18952292 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Ctnnb1 catenin beta 1 increases localization
increases expression
multiple interactions 		ISO Dinoprostone results in increased localization of CTNNB1 protein
Dinoprostone results in increased expression of CTNNB1 protein
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] 		CTD PMID:18395713 PMID:30208247 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]] CTD PMID:21913898 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Dinoprostone results in increased expression of CXCR4 mRNA; Dinoprostone results in increased expression of CXCR4 protein CTD PMID:16303787 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO Dinoprostone results in increased expression of CYP11A1 mRNA CTD PMID:19001523 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Dinoprostone results in increased expression of CYP17A1 mRNA CTD PMID:19001523 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression 		ISO
EXP 		2-methoxyoestrone-3-O-sulphamate inhibits the reaction [Dinoprostone results in increased activity of CYP19A1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ATF3 protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; bakuchiol inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; Chlordan inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; Chlordan inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Dinoprostone inhibits the reaction [NR2F2 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 mRNA]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 protein]; Dinoprostone promotes the reaction [NR5A1 protein binds to CYP19A1 promoter]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]
Dinoprostone results in increased expression of CYP19A1 mRNA; Dinoprostone results in increased expression of CYP19A1 protein 		CTD PMID:15862962 PMID:16024248 PMID:19001523 PMID:20351196 PMID:20678559 More... NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; fulvestrant inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]
Dinoprostone results in increased expression of CYP1B1 mRNA; Dinoprostone results in increased expression of CYP1B1 protein 		CTD PMID:20093341 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Dinoprostone promotes the reaction [DDIT3 protein binds to CXCL8 promoter] CTD PMID:17709599 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO DUSP1 mutant form inhibits the reaction [trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]] CTD PMID:21911040 NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases secretion 		EXP
ISO 		[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]
EDN1 protein results in increased secretion of Dinoprostone 		CTD PMID:16384872 PMID:21811393 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]; Indomethacin promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor increases secretion
increases expression
multiple interactions
increases phosphorylation 		ISO EGFR protein results in increased secretion of Dinoprostone
Dinoprostone results in increased expression of EGFR protein modified form
cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form]; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]
Dinoprostone results in increased phosphorylation of EGFR protein 		CTD PMID:16213893 PMID:17805209 PMID:20850495 PMID:30208247 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:30409902 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO EPHX2 gene mutant form affects the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]] CTD PMID:19896470 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Ereg epiregulin increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of EREG mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA]; U 0126 inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA] 		CTD PMID:16888076 PMID:18444251 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260 		JBrowse link
G Esr1 estrogen receptor 1 increases phosphorylation ISO Dinoprostone results in increased phosphorylation of ESR1 protein CTD PMID:20093341 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
increases expression 		ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA mRNA]; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased expression of ESRRA protein]; Dinoprostone promotes the reaction [ESRRA protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 mRNA]; Dinoprostone promotes the reaction [ESRRA protein results in increased expression of CYP19A1 protein]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; ESRRA protein promotes the reaction [Dinoprostone results in increased expression of CYP19A1 protein]
Dinoprostone results in increased expression of ESRRA mRNA; Dinoprostone results in increased expression of ESRRA protein 		CTD PMID:20351196 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
increases secretion 		EXP
ISO 		[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]
tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]; zinc protoporphyrin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased secretion of Dinoprostone]] 		CTD PMID:21811393 PMID:26385185 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression 		ISO Dinoprostone results in increased expression of FAS
Dinoprostone results in decreased expression of FAS mRNA 		CTD PMID:10357836 PMID:15491851 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand increases expression
multiple interactions
increases response to substance 		ISO Dinoprostone results in increased expression of FASLG
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]
FASLG results in increased susceptibility to Dinoprostone 		CTD PMID:15491851 PMID:25432964 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Dinoprostone promotes the reaction [Celecoxib results in decreased activity of FASN protein] CTD PMID:19159447 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fcer2 Fc epsilon receptor II decreases expression ISO Dinoprostone results in decreased expression of FCER2 protein CTD PMID:1328389 NCBI chr12:6,540,697...6,552,364
Ensembl chr12:6,540,703...6,549,374 		JBrowse link
G Fgf20 fibroblast growth factor 20 increases abundance ISO FGF20 protein results in increased abundance of Dinoprostone CTD PMID:12360478 NCBI chr16:58,734,003...58,741,650
Ensembl chr16:58,734,003...58,741,627 		JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone]; FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone; SB 203580 inhibits the reaction [FGF23 protein results in increased chemical synthesis of and affects the secretion of Dinoprostone] CTD PMID:16144964 NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:161,600,383...161,609,991 		JBrowse link
G Fgf7 fibroblast growth factor 7 increases secretion
multiple interactions 		EXP FGF7 protein results in increased secretion of Dinoprostone
Indomethacin inhibits the reaction [FGF7 protein results in increased secretion of Dinoprostone] 		CTD PMID:16169897 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Dinoprostone results in increased expression of FOS mRNA CTD PMID:10864209 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gast gastrin multiple interactions EXP Dinoprostone inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide increases abundance EXP GHRL results in increased abundance of Dinoprostone CTD PMID:16868036 NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969 		JBrowse link
G Glra3 glycine receptor, alpha 3 multiple interactions
increases response to substance 		ISO Dinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]
GLRA3 results in increased susceptibility to Dinoprostone 		CTD PMID:15131310 NCBI chr16:39,210,534...39,857,332
Ensembl chr16:39,210,536...39,856,764 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Dinoprostone inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31444509 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]] CTD PMID:25432964 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions
affects secretion 		ISO [GPX2 protein affects the activity of PTGS2 protein] which affects the metabolism of Dinoprostone; [GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone
GPX2 protein affects the secretion of Dinoprostone 		CTD PMID:18479189 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases response to substance ISO GRIN2A results in increased susceptibility to Dinoprostone CTD PMID:9113374 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D increases response to substance ISO GRIN2D results in increased susceptibility to Dinoprostone CTD PMID:9113374 NCBI chr 1:105,443,317...105,483,400
Ensembl chr 1:105,444,813...105,481,236 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases phosphorylation ISO Dinoprostone results in increased phosphorylation of GSK3A protein CTD PMID:20578217 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
decreases expression 		ISO Dinoprostone results in increased phosphorylation of GSK3B protein
cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] 		CTD PMID:18395713 PMID:20578217 PMID:30208247 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects chemical synthesis ISO GSTM2 protein affects the chemical synthesis of Dinoprostone CTD PMID:10905636 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 affects chemical synthesis ISO GSTM3 protein affects the chemical synthesis of Dinoprostone CTD PMID:10905636 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions
increases abundance 		EXP [HCRT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone
HCRT results in increased abundance of Dinoprostone 		CTD PMID:18378017 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524 		JBrowse link
G Hgf hepatocyte growth factor increases abundance EXP HGF protein results in increased abundance of Dinoprostone CTD PMID:14751415 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein; [nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]; Dinoprostone promotes the reaction [nickel sulfate results in increased expression of and results in increased activity of HIF1A protein]; Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein; HIF1A protein promotes the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased secretion of CXCL8 protein]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Resveratrol inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with Dinoprostone] results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]
[HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of HIF1A mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] 		CTD PMID:18832182 PMID:20042640 PMID:20335389 PMID:23526216 PMID:28434932 More... NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hk2 hexokinase 2 increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of HK2 mRNA
Dinoprostone promotes the reaction [nickel chloride results in increased expression of HK2 mRNA] 		CTD PMID:27452194 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]
[chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [N-bromotaurine results in decreased abundance of Dinoprostone]; [chromium mesoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [N-chlorotaurine results in decreased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [copper protoporphyrin IX promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]] 		CTD PMID:18157587 PMID:19428335 PMID:22155307 PMID:23942037 PMID:24003391 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase affects abundance
multiple interactions
increases metabolic processing 		ISO HPGD protein affects the abundance of Dinoprostone
[Dinoprostone co-treated with NAD] binds to HPGD protein
HPGD protein results in increased metabolism of Dinoprostone 		CTD PMID:18500342 PMID:19584167 PMID:20448048 PMID:25526675 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP]]; HRH2 protein promotes the reaction [Dinoprostone results in increased abundance of Cyclic AMP] CTD PMID:9187264 NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases activity 		ISO 6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [Dinoprostone results in increased activity of HSD11B1 protein]; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]; Dinoprostone promotes the reaction [HSD11B1 protein affects the oxidation of Hydrocortisone]; PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein] CTD PMID:17761898 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Dinoprostone results in decreased activity of HSD11B2 protein CTD PMID:10377029 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO Dinoprostone results in increased expression of HSD3B2 mRNA CTD PMID:19001523 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:188,784,614...188,790,569 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression 		ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Cadmium Chloride results in increased expression of ICAM1 mRNA]]; Dinoprostone inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dinoprostone results in increased expression of ICAM1 mRNA; Dinoprostone results in increased expression of ICAM1 protein 		CTD PMID:10495789 PMID:16777358 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions
increases abundance
decreases expression 		ISO
EXP 		2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; NFE2L2 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; Probucol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]
Dinoprostone results in decreased expression of IFNG protein
[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; Indomethacin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; nimesulide inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone] 		CTD PMID:9743329 PMID:12911628 PMID:14623498 PMID:15177302 PMID:15788148 More... NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon increases expression ISO Dinoprostone results in increased expression of IGHE protein CTD PMID:15788148
G Il10 interleukin 10 decreases expression
increases abundance
decreases abundance
multiple interactions 		ISO Dinoprostone results in decreased expression of IL10; Dinoprostone results in decreased expression of IL10 protein
IL10 protein results in increased abundance of Dinoprostone
IL10 protein results in decreased abundance of Dinoprostone
Dinoprostone promotes the reaction [Zymosan results in increased expression of IL10 mRNA]; Dinoprostone promotes the reaction [Zymosan results in increased expression of IL10 protein]; IL10 gene mutant form promotes the reaction [Silicon Dioxide results in increased abundance of Dinoprostone]
Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; IL10 protein inhibits the reaction [Endotoxins results in increased abundance of Dinoprostone]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone] 		CTD PMID:7582491 PMID:11301049 PMID:12548226 PMID:14975940 PMID:16303787 More... NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il11 interleukin 11 multiple interactions
increases abundance 		ISO Flurbiprofen inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL11 protein results in increased abundance of Dinoprostone] CTD PMID:12110441 NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:78,096,930...78,104,915 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:11369638 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
increases secretion 		ISO [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
Dinoprostone results in increased expression of IL12B protein
CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]; Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]
Dinoprostone results in increased secretion of IL12B protein
Dinoprostone results in increased expression of IL12B mRNA; Dinoprostone results in increased expression of IL12B protein 		CTD PMID:10614771 PMID:11369638 PMID:15180965 PMID:16303787 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 decreases expression ISO Dinoprostone results in decreased expression of IL12RB1 protein CTD PMID:9743329 NCBI chr16:18,654,207...18,668,887
Ensembl chr16:18,654,207...18,666,824 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 decreases expression ISO Dinoprostone results in decreased expression of IL12RB2 mRNA CTD PMID:9743329 NCBI chr 4:97,756,089...97,844,937
Ensembl chr 4:97,756,089...97,844,937 		JBrowse link
G Il13 interleukin 13 increases secretion ISO Dinoprostone results in increased secretion of IL13 protein CTD PMID:15788148 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO [Dinoprostone co-treated with IL23A] results in increased expression of IL17F; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [IL1B results in increased expression of IL17F] CTD PMID:19273625 NCBI chr 9:30,686,532...30,697,918
Ensembl chr 9:30,686,538...30,697,918 		JBrowse link
G Il17ra interleukin 17 receptor A multiple interactions ISO IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone] CTD PMID:22359662 NCBI chr 4:155,339,742...155,362,382
Ensembl chr 4:155,339,400...155,362,382 		JBrowse link
G Il1a interleukin 1 alpha increases abundance
multiple interactions
increases secretion 		ISO
EXP 		IL1A protein results in increased abundance of Dinoprostone
mofezolac inhibits the reaction [IL1A protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1A protein results in increased abundance of Dinoprostone]
[IL1A protein co-treated with Arachidonic Acid] results in increased abundance of Dinoprostone
IL1A protein results in increased secretion of Dinoprostone 		CTD PMID:8218930 PMID:11351503 PMID:15167967 PMID:16169897 PMID:21513769 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases abundance
increases expression
increases chemical synthesis 		ISO
EXP 		1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; 1-Butanol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; [[Oligomycins co-treated with IL1B protein] results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6; [Dinoprostone co-treated with IL1B] results in increased expression of CCL20; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; [Triclosan co-treated with Cetylpyridinium] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Acetaminophen inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; BAY 11-7085 inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Celecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; ciglitazone promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Cycloheximide inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dactinomycin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone promotes the reaction [IL1B results in increased expression of IL17F]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Glucosamine analog inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Glucosamine inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; HMOX1 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; L 745337 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Oligomycins promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; prolinedithiocarbamate inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; PTGS2 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Quercetin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; Ro 31-8220 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; sargachromanol G inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; sauchinone inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; SC 560 inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Tamoxifen promotes the reaction [Resveratrol inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]]; Triclosan inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]
Dinoprostone results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]
IL1B protein results in increased abundance of Dinoprostone; IL1B results in increased abundance of Dinoprostone
[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; morroniside inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]
2-methoxycinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; CAT protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; cinnamaldehyde inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Dinoprostone inhibits the reaction [IL1B protein results in increased abundance of copper bis(3,5-diisopropylsalicylate)]; Glucosamine inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; GW0072 inhibits the reaction [[IL1B protein co-treated with Rosiglitazone] results in increased secretion of Dinoprostone]; IL1B protein promotes the reaction [PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; IL1B protein promotes the reaction [Rosiglitazone results in increased secretion of Dinoprostone]; Indomethacin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrrolidine dithiocarbamic acid inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; sulforaphane inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Dinoprostone]; theaflavin-3,3'-digallate inhibits the reaction [IL1B protein results in increased abundance of and results in increased secretion of Dinoprostone]
Dinoprostone results in increased expression of IL1B protein 		CTD PMID:1515551 PMID:7582491 PMID:8662662 PMID:9266823 PMID:10614771 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases activity
increases expression 		ISO Dinoprostone results in increased activity of IL1R1 protein
Dinoprostone results in increased expression of IL1R1 mRNA 		CTD PMID:19273625 PMID:19407222 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Dinoprostone inhibits the reaction [IL1RN protein results in decreased expression of IL6 protein]; IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]] CTD PMID:8520508 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Dinoprostone results in decreased expression of IL2; Dinoprostone results in decreased expression of IL2 protein CTD PMID:2948675 PMID:2989362 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il22 interleukin 22 decreases expression ISO Dinoprostone results in decreased expression of IL22 CTD PMID:19273625 NCBI chr 7:55,687,061...55,691,526
Ensembl chr 7:55,686,896...55,692,201 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions
increases expression 		ISO [Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6; [Dinoprostone co-treated with IL23A] results in increased expression of IL17F; Dinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of IL17F]; Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA]; Dinoprostone promotes the reaction [IL23A results in increased expression of CCL20]; IL23A promotes the reaction [[Dinoprostone co-treated with IL1B] results in increased expression of CCL20]
Dinoprostone results in increased expression of IL23A protein
CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]; Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]
Dinoprostone results in increased expression of IL23A mRNA 		CTD PMID:15180965 PMID:19273625 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Dinoprostone results in decreased expression of IL2RA CTD PMID:2948675 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma decreases expression ISO Dinoprostone results in decreased expression of IL2RG CTD PMID:19812686 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:70,435,343...70,439,161 		JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions
decreases secretion
increases response to substance 		ISO Dinoprostone results in increased secretion of IL4 protein; IL4 protein results in increased secretion of Dinoprostone
[IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; luliconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]
IL4 results in decreased secretion of Dinoprostone
IL4 protein results in increased susceptibility to Dinoprostone 		CTD PMID:12370375 PMID:15788148 PMID:18952292 PMID:19767084 PMID:23688403 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 increases secretion ISO Dinoprostone results in increased secretion of IL5 protein CTD PMID:15788148 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		ISO
EXP 		[Dinoprostone co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; Dinoprostone inhibits the reaction [IL1RN protein results in decreased expression of IL6 protein]; Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; IL1RN protein inhibits the reaction [Dinoprostone inhibits the reaction [Indomethacin results in decreased expression of IL6 protein]]
[IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [IL6 protein results in increased expression of PTGS2 mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; Celecoxib inhibits the reaction [IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; IL6 protein results in increased secretion of and results in increased abundance of Dinoprostone
Dinoprostone results in increased expression of IL6 protein
Dexamethasone inhibits the reaction [Dinoprostone results in increased expression of IL6 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Lipopolysaccharides promotes the reaction [Dinoprostone results in increased expression of IL6 protein] 		CTD PMID:7536779 PMID:8520508 PMID:15180965 PMID:15379866 PMID:16303787 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression ISO prostaglandin E2 increases expression of Irak3 protein in alveolar macrophages RGD PMID:20439918 RGD:36049799 NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO
EXP 		ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]; TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]]
ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] 		CTD PMID:18234883 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Dinoprostone CTD PMID:14984413 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Jak3 Janus kinase 3 multiple interactions ISO Dinoprostone results in decreased phosphorylation of and results in decreased activity of JAK3 protein CTD PMID:19812686 NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222 		JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO KAT2B protein affects the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; KAT2B protein affects the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; KAT2B protein affects the reaction [Dinoprostone results in increased expression of CYP19A1 protein] CTD PMID:30409902 NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616 		JBrowse link
G Kng1 kininogen 1 increases abundance
increases secretion
multiple interactions 		EXP KNG1 protein alternative form results in increased abundance of Dinoprostone; KNG1 protein results in increased abundance of Dinoprostone
KNG1 protein modified form results in increased secretion of Dinoprostone
[KNG1 protein co-treated with Dinoprostone] results in increased secretion of CALCA protein; [KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone; [KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone; [Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of Dinoprostone]; Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Dinoprostone promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]; Flurbiprofen inhibits the reaction [[KNG1 protein co-treated with Serotonin co-treated with Histamine] results in increased abundance of Dinoprostone]; Flurbiprofen inhibits the reaction [[Serotonin co-treated with Histamine] promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine]; nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; Serotonin promotes the reaction [KNG1 protein results in increased abundance of Dinoprostone]; Streptozocin promotes the reaction [KNG1 protein modified form results in increased secretion of Dinoprostone] 		CTD PMID:4030047 PMID:11166334 PMID:12791437 PMID:18234883 PMID:20832942 More... NCBI chr11:91,317,354...91,340,148
Ensembl chr11:91,317,355...91,340,148 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression 		ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of LDHA mRNA]
Dinoprostone results in increased expression of LDHA mRNA 		CTD PMID:27452194 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Lep leptin increases abundance
increases secretion
increases expression 		EXP LEP protein results in increased abundance of Dinoprostone
Dinoprostone results in increased secretion of LEP protein
Dinoprostone results in increased expression of LEP protein 		CTD PMID:11060898 PMID:16015682 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO MAP3K8 protein affects the reaction [arsenite results in increased secretion of Dinoprostone] CTD PMID:19808956 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
decreases phosphorylation
increases phosphorylation
multiple interactions 		ISO
EXP 		Dinoprostone results in increased activity of MAPK1 protein
Dinoprostone results in decreased phosphorylation of MAPK1 protein
Dinoprostone results in increased phosphorylation of MAPK1 protein
Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK1 protein]
gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK1 protein] 		CTD PMID:16888076 PMID:17805209 PMID:18030065 PMID:18056380 PMID:19201774 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity
increases phosphorylation
multiple interactions 		ISO
EXP 		Dinoprostone results in increased activity of MAPK14 protein
Dinoprostone results in increased phosphorylation of MAPK14 protein
L-826266 inhibits the reaction [Dinoprostone results in increased activity of MAPK14 protein] 		CTD PMID:16644903 PMID:18030065 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity
decreases phosphorylation
increases phosphorylation
multiple interactions 		ISO
EXP 		Dinoprostone results in increased activity of MAPK3 protein
Dinoprostone results in decreased phosphorylation of MAPK3 protein
Dinoprostone results in increased phosphorylation of MAPK3 protein
Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK3 protein]
gefitinib inhibits the reaction [Dinoprostone results in increased phosphorylation of MAPK3 protein] 		CTD PMID:16888076 PMID:17805209 PMID:18030065 PMID:18056380 PMID:19201774 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions 		ISO Dinoprostone results in increased activity of MAPK8 protein
L-826266 inhibits the reaction [Dinoprostone results in increased activity of MAPK8 protein] 		CTD PMID:16644903 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein] CTD PMID:25094029 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CCN2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] CTD PMID:28434932 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
increases secretion 		ISO Dinoprostone results in increased expression of MMP9 mRNA; Dinoprostone results in increased expression of MMP9 protein
15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; 15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Fenofibrate inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; Fenofibrate inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein] 		CTD PMID:16330497 PMID:19880272 PMID:25094029 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:22039321 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]] CTD PMID:22363816 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Muc1 mucin 1, cell surface associated multiple interactions ISO [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein CTD PMID:18952292 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression 		ISO
EXP 		Dinoprostone results in increased expression of MYC; Dinoprostone results in increased expression of MYC protein
Dinoprostone results in decreased expression of MYC 		CTD PMID:1315190 PMID:8667251 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions 		EXP Dinoprostone results in increased expression of MYH7 protein
Colforsin inhibits the reaction [Dinoprostone results in increased expression of MYH7 protein] 		CTD PMID:18851973 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [IFNG protein results in increased abundance of Dinoprostone]; NFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone] CTD PMID:23942037 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects activity 		ISO [L-335677 co-treated with 6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with L-826266 co-treated with L-161982] inhibits the reaction [Dinoprostone affects the activity of NFKB1 protein] CTD PMID:18297109 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein]
Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]] 		CTD PMID:22188298 PMID:25432964 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngf nerve growth factor multiple interactions
increases secretion 		EXP Acetaminophen affects the reaction [NGF protein results in increased secretion of Dinoprostone]; nimesulide inhibits the reaction [NGF protein results in increased secretion of Dinoprostone] CTD PMID:21811393 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases response to substance 		ISO
EXP 		[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone; honokiol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Dinoprostone]
Dinoprostone inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; Dinoprostone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]
NOS2 results in increased susceptibility to Dinoprostone
[Ozone results in increased expression of NOS2 protein] which results in increased abundance of Dinoprostone; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone] 		CTD PMID:11919077 PMID:15491851 PMID:16325209 PMID:16944022 PMID:21147091 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions
increases abundance 		EXP Dinoprostone results in increased expression of NPPA mRNA; Dinoprostone results in increased expression of NPPA protein
Colforsin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein]
NPPA protein results in increased abundance of Dinoprostone 		CTD PMID:3070145 PMID:18030065 PMID:18851973 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Nppb natriuretic peptide B increases expression EXP Dinoprostone results in increased expression of NPPB mRNA CTD PMID:18030065 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 multiple interactions ISO Dinoprostone inhibits the reaction [NR2F2 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [NR2F2 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 1:133,419,161...133,434,290
Ensembl chr 1:133,420,227...133,431,975 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of NR4A2
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein] 		CTD PMID:16293616 PMID:22188298 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO Dinoprostone promotes the reaction [NR5A1 protein binds to CYP19A1 promoter]; Dinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:42,875,221...42,896,046 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions
increases expression 		ISO Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]]
Dinoprostone results in increased expression of NRG1 mRNA 		CTD PMID:16357062 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions EXP Dinoprostone inhibits the reaction [Carbon Tetrachloride results in increased expression of ORM1 mRNA] CTD PMID:15816358 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667 		JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]] CTD PMID:25432964 NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]] CTD PMID:26691871 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein] CTD PMID:19289254 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
increases abundance 		ISO 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Celecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Dinoprostone] CTD PMID:19201774 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO Dinoprostone results in decreased expression of PKLR mRNA CTD PMID:10357836 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression ISO Dinoprostone results in increased expression of PLA2G2A protein CTD PMID:15964894 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]
[Cadmium results in increased activity of PLA2G4A protein] which results in increased abundance of Dinoprostone 		CTD PMID:15212812 PMID:15878913 PMID:20850495 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Pla2g5 phospholipase A2, group V multiple interactions ISO PLA2G5 protein promotes the reaction [Zymosan results in increased metabolism of Dinoprostone] CTD PMID:14761945 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:156,324,629...156,381,926 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] CTD PMID:17640750 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] CTD PMID:17640750 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone] CTD PMID:19748995 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B multiple interactions
decreases expression
increases expression 		EXP fulvestrant inhibits the reaction [Dinoprostone results in decreased expression of PPP1R9B protein]; PTGER1 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein] CTD PMID:17408863 PMID:18726914 PMID:23054057 NCBI chr10:80,434,888...80,450,919
Ensembl chr10:80,434,900...80,450,919 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of PRKACA protein CTD PMID:22188298 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkce protein kinase C, epsilon affects response to substance EXP PRKCE protein affects the susceptibility to Dinoprostone CTD PMID:18509033 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288 		JBrowse link
G Prl prolactin multiple interactions ISO Dinoprostone promotes the reaction [[Estradiol co-treated with Medroxyprogesterone Acetate] results in increased expression of PRL mRNA] CTD PMID:7506205 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Prodh1 proline dehydrogenase 1 multiple interactions ISO [PRODH results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone CTD PMID:18794809 NCBI chr11:96,414,275...96,431,604
Ensembl chr11:96,414,224...96,433,418 		JBrowse link
G Psen2 presenilin 2 multiple interactions ISO [PSEN2 protein mutant form results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone CTD PMID:16331303 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116 		JBrowse link
G Pten phosphatase and tensin homolog increases activity
multiple interactions
decreases phosphorylation 		EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; Dinoprostone results in increased activity of PTEN protein
dioctanoyl-phosphatidylinositol 4,5-bisphosphate inhibits the reaction [Dinoprostone results in decreased phosphorylation of PTEN protein]; oxodiperoxo(pyridine-2-carboxylate)vanadate(V) inhibits the reaction [Dinoprostone results in increased activity of PTEN protein] 		CTD PMID:18056380 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO Dinoprostone binds to and results in increased activity of PTGDR protein; Dinoprostone inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:27636113 NCBI chr15:19,790,499...19,797,873
Ensembl chr15:19,790,499...19,797,873 		JBrowse link
G Ptger1 prostaglandin E receptor 1 increases response to substance
multiple interactions
increases activity 		ISO
EXP 		PTGER1 protein results in increased susceptibility to Dinoprostone; PTGER1 results in increased susceptibility to Dinoprostone
PTGER1 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased abundance of Inositol Phosphates; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein; [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA; [Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of PRKACA protein; [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Dinoprostone binds to and results in increased activity of PTGER1 protein; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of NFKBIA protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]
Dinoprostone results in increased activity of PTGER1 protein 		CTD PMID:11375261 PMID:15126118 PMID:15311063 PMID:17408863 PMID:20335389 More... NCBI chr19:41,374,983...41,379,593
Ensembl chr19:41,374,471...41,378,284 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases activity
increases expression 		ISO
EXP 		[[Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER2 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein]; Dinoprostone binds to and results in increased activity of PTGER2 protein; Dinoprostone inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of [PTGER2 protein co-treated with GLRA3 protein]]; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER2 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER2 protein] which results in increased chemical synthesis of Cyclic AMP]; PTGER2 protein promotes the reaction [Dinoprostone results in increased activity of HSD11B1 protein]
PTGER2 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein] 		CTD PMID:15131310 PMID:15930264 PMID:17408863 PMID:17709599 PMID:17761898 More... NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
increases expression
affects binding
increases activity
affects response to substance 		ISO
EXP 		[Dinoprostone results in increased activity of PTGER3 protein] which results in decreased abundance of Cyclic AMP; Dinoprostone binds to and results in increased activity of PTGER3 protein
Dinoprostone binds to and results in increased activity of PTGER3 protein; Endocannabinoids inhibits the reaction [Dinoprostone binds to and results in increased activity of PTGER3 protein]
Dinoprostone results in increased expression of PTGER3 mRNA
Dinoprostone binds to PTGER3 protein; Dinoprostone binds to PTGER3 protein alternative form
PTGER3 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]; PTGER3 protein affects the reaction [Dinoprostone results in decreased transport of Calcium]
PTGER3 affects the susceptibility to Dinoprostone 		CTD PMID:10357836 PMID:11375261 PMID:12535167 PMID:14636300 PMID:15937517 More... NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions
increases expression
increases activity 		ISO
EXP 		Dinoprostone binds to and results in decreased activity of PTGER4 protein
Dinoprostone results in increased expression of PTGER4 protein
PTGER4 mutant form inhibits the reaction [Dinoprostone results in increased expression of PPP1R9B protein]
Dinoprostone results in increased expression of PTGER4 mRNA
[[Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate] which results in increased secretion of CXCL8 protein; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP; [Dinoprostone results in increased activity of PTGER4 protein] which results in increased susceptibility to nickel sulfate; cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein]; nickel sulfate promotes the reaction [[Dinoprostone results in increased activity of PTGER4 protein] which results in increased chemical synthesis of Cyclic AMP] 		CTD PMID:10800959 PMID:12009843 PMID:17408863 PMID:23526216 PMID:30208247 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:56,062,890...56,074,135 		JBrowse link
G Ptges prostaglandin E synthase increases abundance
multiple interactions 		ISO
EXP 		PTGES results in increased abundance of Dinoprostone
[Diclofenac results in decreased expression of PTGES mRNA] which results in decreased abundance of Dinoprostone
[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone; [Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]; HIF1A protein promotes the reaction [[Oxygen deficiency results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone]; HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [[IL1B protein results in increased expression of PTGES protein] which results in increased abundance of Dinoprostone]]
[GPX2 protein affects the expression of PTGES protein] which affects the metabolism of Dinoprostone; [IL6 protein results in increased expression of PTGES mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [Lithium Chloride results in increased expression of PTGES protein] which results in increased chemical synthesis of Dinoprostone; [Tetrachlorodibenzodioxin results in increased expression of PTGES mRNA] which results in increased chemical synthesis of Dinoprostone; PTGES protein affects the reaction [Tetrachlorodibenzodioxin results in increased abundance of Dinoprostone] 		CTD PMID:17369862 PMID:18479189 PMID:19393675 PMID:19428335 PMID:19692487 More... NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995 		JBrowse link
G Ptges2 prostaglandin E synthase 2 multiple interactions ISO
EXP 		2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone]; [Lipopolysaccharides results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone
2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid inhibits the reaction [[Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone]; [Carrageenan results in increased activity of PTGES2 protein] which results in increased chemical synthesis of Dinoprostone; PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone] 		CTD PMID:19934399 PMID:20171164 NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:36,088,246...36,097,694 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions
increases chemical synthesis 		ISO
EXP 		Indomethacin inhibits the reaction [PTGS1 protein results in increased chemical synthesis of Dinoprostone]; PTGS1 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]
[resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone results in decreased susceptibility to [resveratrol results in decreased activity of PTGS1 protein]
[mofezolac results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; [resveratrol results in decreased activity of PTGS1 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] which results in decreased abundance of Dinoprostone; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of CEBPA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased degradation of and results in decreased expression of NFKBIA protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BAK1 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of FASL protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]] 		CTD PMID:10594344 PMID:16354411 PMID:16894348 PMID:19066340 PMID:19751497 More... NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases chemical synthesis
multiple interactions
affects abundance
increases expression
increases abundance 		ISO
EXP 		PTGS2 protein results in increased chemical synthesis of Dinoprostone
1-phenyl-6,7-dihydroxy-isochroman inhibits the reaction [[Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; 3,4-dihydroxyphenylethanol inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased abundance of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [[Oligomycins co-treated with IL1B protein] results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [amentoflavone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Arachidonic Acid results in increased abundance of Dinoprostone] promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; [baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; [Bupivacaine results in increased expression of PTGS2] which results in increased abundance of Dinoprostone; [Celecoxib analog results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Dronabinol results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Etodolac results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone; [Genistein inhibits the reaction [Fluorouracil results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [Hydrogen Peroxide results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of and results in increased secretion of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Melitten results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Meloxicam results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nickel sulfate co-treated with Dinoprostone] results in increased expression of PTGS2 protein; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Particulate Matter results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; [PRODH results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; [PSEN2 protein mutant form results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [PTGS2 co-treated with Dinoprostone] results in increased expression of VEGFA; [PTGS2 protein results in increased chemical synthesis of Dinoprostone] which results in decreased susceptibility to Fenretinide; [PTGS2 protein results in increased chemical synthesis of Dinoprostone] which results in decreased susceptibility to Tamoxifen; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [SC 791 results in decreased activity of PTGS2 protein] inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased abundance of Dinoprostone]; [Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [TGFB1 results in increased expression of PTGS2] which results in increased abundance of Dinoprostone; [TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone; [Tobacco Smoke Pollution results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Vehicle Emissions results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; acadesine inhibits the reaction [[Fluorouracil results in increased expression of PTGS2 protein] which results in increased abundance of and results in increased secretion of Dinoprostone]; arzanol inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Celecoxib inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Cycloheximide inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dexamethasone inhibits the reaction [[Particulate Matter results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [[Vehicle Emissions results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; Dexamethasone inhibits the reaction [Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Dinoprostone promotes the reaction [Arachidonic Acid results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]; Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Dinoprostone promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; DUSP1 mutant form inhibits the reaction [trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]]; Etodolac inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Flurbiprofen inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone]; Ibuprofen inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]; Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; lucidone inhibits the reaction [2,2'-azobis(2-amidinopropane) promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; nimesulide inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; oleuropein inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone; PTGS2 protein promotes the reaction [IL1B protein results in increased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; Resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; SB 203580 inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]]; trichostatin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
[DuP 697 results in decreased expression of PTGS2] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Dinoprostone]; [HCRT results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [IL1B protein results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprostone; [nimesulide results in decreased expression of PTGS2 protein] which results in decreased abundance of Dinoprostone; [o,p'-DDT results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprostone; [PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; ciglitazone promotes the reaction [[PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Dinoprostone inhibits the reaction [Indomethacin results in increased expression of PTGS2]; Dinoprostone results in decreased susceptibility to [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein]; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein]; endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; IL1B protein promotes the reaction [PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Meloxicam inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; PTGS2 protein results in increased chemical synthesis of and results in increased secretion of Dinoprostone; pyrrolidine dithiocarbamic acid inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Troglitazone inhibits the reaction [[PAR-1-activating peptide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; wuzi yanzong analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]
PTGS2 protein affects the abundance of Dinoprostone metabolite
Dinoprostone results in increased expression of [IL1B protein results in increased expression of PTGS2 protein]; Dinoprostone results in increased expression of PTGS2 mRNA; Dinoprostone results in increased expression of PTGS2 protein
PTGS2 protein mutant form results in increased abundance of Dinoprostone metabolite; PTGS2 protein results in increased abundance of Dinoprostone
[Thiamine deficiency results in increased expression of PTGS2 mRNA] which results in increased expression of Dinoprostone
3-caffeoyl-4-dicaffeoylquinic acid inhibits the reaction [phorbolol myristate acetate promotes the reaction [PTGS2 protein results in increased abundance of Dinoprostone]]; 4-hydroxyphenylethanol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone; [[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [[nimesulide results in decreased activity of PTGS2 protein] co-treated with [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid binds to and results in increased activity of PPARD protein]] results in decreased abundance of Dinoprostone; [Acetaminophen results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [Cadmium results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Cadmium results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [GPX2 protein affects the activity of PTGS2 protein] which affects the metabolism of Dinoprostone; [IL6 protein results in increased expression of PTGS2 mRNA] which results in increased secretion of and results in increased abundance of Dinoprostone; [KT 5720 co-treated with Dinoprostone] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; [Lipids results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone; [Melitten results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Mycoplasma arthritidis mitogen results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [nonylphenol results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [o,p'-DDT results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone; [sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; [Zymosan results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Capsaicin inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Capsaicin inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; capsazepine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Carthamus yellow inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased expression of BIRC5 protein]; Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein]; Dinoprostone inhibits the reaction [copper protoporphyrin IX inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]]; Dinoprostone promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Drugs, Chinese Herbal inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Eugenol inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased abundance of Dinoprostone]; flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; Glucosamine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased secretion of Dinoprostone]; IL17RA gene mutant form inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; Lipopolysaccharides promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; nimesulide inhibits the reaction [[soluble tachyzoite antigen, Toxoplasma gondii results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; phorbolol myristate acetate promotes the reaction [PTGS2 protein results in increased abundance of Dinoprostone]; piperine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; PPARD protein affects the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; PPARD protein mutant form inhibits the reaction [[nimesulide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Resveratrol inhibits the reaction [[Lipids results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Selenium deficiency promotes the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone] 		CTD PMID:7575673 PMID:8621535 PMID:8662662 PMID:9266823 PMID:9321948 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 increases activity EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; [Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein CTD PMID:18056380 NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069 		JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases activity EXP [[Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein] which results in increased activity of PTEN protein; [Dinoprostone results in increased activity of RAPGEF3 protein] which results in increased activity of PTPN6 protein; Dinoprostone results in increased activity of RAPGEF3 protein CTD PMID:18056380 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:130,754,871...130,777,668 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein]
Dinoprostone inhibits the reaction [copper protoporphyrin IX inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]]; Dinoprostone promotes the reaction [Lipopolysaccharides affects the localization of RELA protein] 		CTD PMID:22188298 PMID:24003391 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin multiple interactions ISO [Sodium, Dietary deficiency results in increased susceptibility to Dinoprostone] which results in increased secretion of REN protein CTD PMID:10432392 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Retn resistin increases secretion ISO RETN protein results in increased secretion of Dinoprostone CTD PMID:23827175 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of RORC
Dinoprostone promotes the reaction [[IL1B co-treated with IL23A] results in increased expression of RORC mRNA] 		CTD PMID:19273625 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO [Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein; Pertussis Toxin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] CTD PMID:20335389 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Dinoprostone results in increased expression of RUNX2 mRNA; Dinoprostone results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression 		ISO Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]
Dinoprostone results in decreased expression of SIRT1 mRNA; Dinoprostone results in decreased expression of SIRT1 protein
1-(4-fluorobenzoyl)-3-(((6-methoxy-2-naphthyl)oxy)methyl)azetidine-3-carboxylic acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; 4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; ATF3 protein affects the reaction [Dinoprostone results in decreased expression of SIRT1 mRNA]; Dinoprostone promotes the reaction [ATF3 protein binds to SIRT1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter]]; SIRT1 protein inhibits the reaction [Dinoprostone promotes the reaction [HIF1A protein binds to EP300 protein]]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of and results in increased acetylation of HIF1A protein]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 mRNA]; SIRT1 protein inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]] 		CTD PMID:20335659 PMID:20844277 PMID:23257246 PMID:30409902 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 multiple interactions ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of SLC16A3 mRNA] CTD PMID:27452194 NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903 		JBrowse link
G Slc22a22 solute carrier family 22 member 22 increases transport
affects binding 		ISO SLC22A22 protein results in increased transport of Dinoprostone
Dinoprostone binds to SLC22A22 protein 		CTD PMID:20448048 NCBI chr 7:90,610,007...90,639,718
Ensembl chr 7:90,610,009...90,639,695 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Dinoprostone results in decreased expression of SLC22A6 protein CTD PMID:19605544 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake 		ISO SLC22A7 protein results in increased transport of Dinoprostone
SLC22A7 protein results in increased uptake of Dinoprostone 		CTD PMID:12065749 PMID:15901346 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport
decreases expression
affects transport 		ISO
EXP 		SLC22A8 protein results in increased transport of Dinoprostone
Dinoprostone results in decreased expression of SLC22A8 protein
SLC22A8 protein affects the transport of Dinoprostone 		CTD PMID:11306713 PMID:15100168 PMID:19605544 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases expression 		ISO Dinoprostone promotes the reaction [nickel chloride results in increased expression of SLC2A1 mRNA]
Dinoprostone results in increased expression of SLC2A1 mRNA 		CTD PMID:27452194 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions
increases transport 		ISO Diclofenac inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Indomethacin promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; lumiracoxib inhibits the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]; Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO SOD2 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone] CTD PMID:14514642 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO Dinoprostone inhibits the reaction [Celecoxib inhibits the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]] CTD PMID:29396848 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Dinoprostone results in increased expression of SOX9 mRNA; Dinoprostone results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression
decreases expression 		ISO Dinoprostone inhibits the reaction [NR2F2 protein binds to STAR promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter]; Dinoprostone promotes the reaction [NR5A1 protein binds to STAR promoter]
Dinoprostone results in increased expression of STAR mRNA; Dinoprostone results in increased expression of STAR protein
Dinoprostone results in decreased expression of STAR mRNA 		CTD PMID:19001523 PMID:19253104 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Dinoprostone inhibits the reaction [[Indomethacin results in decreased activity of PTGS2 protein] which results in decreased phosphorylation of STAT3 protein]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]] CTD PMID:21268125 PMID:25432964 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Dinoprostone promotes the reaction [Histamine promotes the reaction [Serotonin promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]]]; Dinoprostone promotes the reaction [Kallidin results in increased secretion of TAC1 protein]; Dinoprostone promotes the reaction [KNG1 protein results in increased secretion of TAC1 protein]; ITGA2 protein results in increased susceptibility to [KNG1 protein modified form co-treated with TAC1 protein modified form co-treated with Serotonin co-treated with Dinoprostone co-treated with Histamine] CTD PMID:11166334 PMID:16039053 PMID:18234883 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Dinoprostone results in decreased expression of TBX21 mRNA CTD PMID:19273625 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO Dinoprostone results in decreased expression of TFRC protein CTD PMID:2989362 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression 		ISO
EXP 		[TGFB1 results in increased expression of PTGS2] which results in increased abundance of Dinoprostone
[CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]
Dinoprostone results in decreased expression of TGFB1 mRNA
Dinoprostone inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA] 		CTD PMID:8877289 PMID:16489006 PMID:28434932 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA] CTD PMID:28434932 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO CCL12 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]; HIF1A protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]; MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]] CTD PMID:28434932 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA] CTD PMID:28434932 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO [CCL12 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [HIF1A protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]; [MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA] CTD PMID:28434932 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO Dinoprostone results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions 		ISO Dinoprostone results in increased expression of TIMP1 mRNA; Dinoprostone results in increased expression of TIMP1 protein
Dinoprostone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]] 		CTD PMID:16330497 PMID:25432964 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone; Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] CTD PMID:20040740 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases abundance
decreases expression 		ISO
EXP 		1-carboxyheptylimidazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of CCR7 protein; [IL4 protein co-treated with CSF2 protein co-treated with TNF protein co-treated with Dinoprostone co-treated with IL1B protein co-treated with IL6 protein] results in increased expression of MUC1 protein; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone; [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein; [Triclosan co-treated with Cetylpyridinium] inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; cyanidin-3-O-beta-glucopyranoside inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dinoprostone inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Dinoprostone]; Indomethacin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; pyrrolidine dithiocarbamic acid promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]]; sorbinil inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased metabolism of Dinoprostone]; Triclosan inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; wedelolactone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]
TNF protein results in increased abundance of Dinoprostone; TNF protein results in increased abundance of Dinoprostone metabolite
Dinoprostone results in decreased expression of TNF protein
Benzo(a)pyrene promotes the reaction [TNF protein results in increased abundance of Dinoprostone]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone metabolite]; Dexamethasone inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Dinoprostone analog inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; TNF protein promotes the reaction [Benzo(a)pyrene results in increased abundance of Dinoprostone]
[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone; Adenosine Triphosphate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Dinoprostone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; Dinoprostone inhibits the reaction [Zymosan results in increased expression of TNF protein]; Melitten inhibits the reaction [[TNF protein results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Tetradecanoylphorbol Acetate promotes the reaction [[TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Dinoprostone]
TNF protein results in increased abundance of Dinoprostone; TNF results in increased abundance of Dinoprostone 		CTD PMID:1515551 PMID:1993070 PMID:7536779 PMID:9298541 PMID:9576062 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions
increases secretion
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Dinoprostone results in increased secretion of TNFRSF11B protein]
Dinoprostone results in increased expression of TNFRSF11B mRNA 		CTD PMID:25234201 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases activity ISO Dinoprostone results in increased activity of TNFRSF1A protein CTD PMID:19407222 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Trpc7 transient receptor potential cation channel, subfamily C, member 7 increases response to substance ISO TRPC7 results in increased susceptibility to Dinoprostone CTD PMID:16790996 NCBI chr17:7,707,954...7,839,064
Ensembl chr17:7,714,505...7,838,745 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions ISO TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] CTD PMID:18234883 NCBI chr12:47,599,161...47,638,143
Ensembl chr12:47,599,035...47,638,143 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP UCP1 protein inhibits the reaction [Glucose results in increased chemical synthesis of Dinoprostone] CTD PMID:14514642 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases chemical synthesis EXP UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprostone CTD PMID:3864191 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO Dinoprostone results in increased phosphorylation of VASP protein CTD PMID:18182247 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [[Cisplatin co-treated with ciglitazone] results in decreased expression of VEGFA] which results in decreased abundance of Dinoprostone; [nickel sulfate co-treated with Dinoprostone] results in increased secretion of VEGFA protein; [PTGS2 co-treated with Dinoprostone] results in increased expression of VEGFA CTD PMID:12821125 PMID:18832182 PMID:21681689 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Dinoprostone results in decreased expression of VEGFC mRNA; Dinoprostone results in decreased expression of VEGFC protein CTD PMID:18509974 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887 		JBrowse link
G Vgf VGF nerve growth factor inducible increases abundance EXP VGF results in increased abundance of Dinoprostone CTD PMID:20805684 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Dinoprostone inhibits the reaction [WT1 protein binds to CYP19A1 promoter]; Dinoprostone inhibits the reaction [WT1 protein binds to STAR promoter] CTD PMID:19001523 NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444 		JBrowse link
Term paths to the root
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  CHEBI ontology 20874
    role 20844
      application 20572
        pharmaceutical 20359
          drug 20359
            oxytocic 248
              (11R,16S)-misoprostol + 15
              carbetocin 0
              carboprost 0
              carboprost tromethamine 0
              demoxytocin 0
              ergometrine + 0
              ergometrine maleate 0
              ergotamine 5
              misoprostol 15
              oxytocin 21
              prostaglandin E2 232
              prostaglandin E2(1-) 0
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