antiviral drug - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antiviral drug	go back to main search page
Accession:	CHEBI:36044	browse the term
Definition:	A substance used in the prophylaxis or therapy of virus diseases.
Synonyms:	related_synonym:	anti-viral drug; anti-virus drug; antiviral drugs

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Rat (2035 ) Mouse (2011 ) Human (2055 ) Chinchilla (0 ) Bonobo (0 ) Dog (9 ) Squirrel (0 ) Pig (32 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (2035)

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases cleavage
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases cleavage

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin B1

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cell division cycle 25C

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cytochrome c, somatic

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA; 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 beta

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase 1

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased phosphorylation of MAPK8 protein
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone affects the localization of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of and affects the stability of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

increases expression
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA
NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions
decreases phosphorylation

ISO

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of PIK3R1 protein]

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

sequestosome 1

increases expression

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

tumor necrosis factor

multiple interactions

ISO

2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; NFE2L2 protein affects the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

5-iodo-2'-deoxyuridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

methyl-CpG binding domain 4 DNA glycosylase

affects response to substance

ISO

MBD4 protein affects the susceptibility to Idoxuridine

NCBI chr 4:150,565,646...150,577,433
Ensembl chr 4:150,565,655...150,577,578

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

Idoxuridine results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

solute carrier family 28 member 1

multiple interactions

EXP

Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]

NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:144,490,623...144,531,544

G

thymidylate synthetase

affects uptake

ISO

TYMS protein affects the uptake of Idoxuridine

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

multiple interactions
increases export
decreases export

ISO

[Estradiol results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of abacavir]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of abacavir]

PMID:17437964 PMID:19056916 PMID:25844889

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

albumin

affects binding
multiple interactions

ISO

abacavir binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 1 family, member A2

decreases expression

ISO

abacavir results in decreased expression of ALDH1A2 mRNA

NCBI chr 8:80,758,641...80,837,891
Ensembl chr 8:80,758,142...80,837,883

G

C-reactive protein

increases expression

ISO

abacavir results in increased expression of CRP protein

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

abacavir results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

abacavir results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

ISO

abacavir results in decreased expression of EYA1 mRNA

NCBI chr 5:9,646,599...9,884,609
Ensembl chr 5:9,646,591...9,884,614

G

fibroblast growth factor 8

increases expression

ISO

abacavir results in increased expression of FGF8 mRNA

NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:254,533,504...254,539,605

G

forkhead box C2

decreases expression

ISO

abacavir results in decreased expression of FOXC2 mRNA

NCBI chr19:66,094,718...66,097,420
Ensembl chr19:66,094,700...66,153,977

G

glial fibrillary acidic protein

increases expression

ISO

abacavir results in increased expression of GFAP protein

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

homeo box B7

increases expression

ISO

abacavir results in increased expression of HOXB7 mRNA

NCBI chr10:81,749,159...81,752,577
Ensembl chr10:81,749,097...81,752,550

G

homeo box B9

increases expression

ISO

abacavir results in increased expression of HOXB9 mRNA

NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,733,658...81,738,872

G

interferon gamma

multiple interactions

ISO

[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 13

multiple interactions

ISO

[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 4

affects response to substance

ISO

IL4 protein affects the susceptibility to abacavir

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

mesenchyme homeobox 1

decreases expression

ISO

abacavir results in decreased expression of MEOX1 mRNA

NCBI chr10:87,318,668...87,338,169
Ensembl chr10:87,318,695...87,337,976

G

mesoderm posterior bHLH transcription factor 2

decreases expression

ISO

abacavir results in decreased expression of MESP2 mRNA

NCBI chr 1:143,165,914...143,168,520
Ensembl chr 1:143,165,849...143,168,511

G

matrix metallopeptidase 9

increases expression

ISO

abacavir results in increased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

increases expression

ISO

abacavir results in increased expression of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

neurogenin 2

increases expression

ISO

abacavir results in increased expression of NEUROG2 mRNA

NCBI chr 2:218,767,205...218,769,772
Ensembl chr 2:218,765,949...218,769,784

G

oligodendrocyte transcription factor 3

increases expression

ISO

abacavir results in increased expression of OLIG3 mRNA

NCBI chr 1:15,900,881...15,902,953
Ensembl chr 1:15,900,736...15,902,274

G

paired box 3

decreases expression

ISO

abacavir results in decreased expression of PAX3 mRNA

NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:87,016,999...87,124,141

G

paired box 6

increases expression

ISO

abacavir results in increased expression of PAX6 mRNA

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763

G

programmed cell death 1

multiple interactions

ISO

[HLA-B protein alternative form results in increased susceptibility to abacavir] which results in increased expression of PDCD1

NCBI chr 9:101,866,124...101,879,278
Ensembl chr 9:101,866,126...101,879,270

G

solute carrier family 22 member 1

multiple interactions

ISO

[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

synaptophysin

increases expression

ISO

abacavir results in increased expression of SYP protein

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

transcription factor 15

decreases expression

ISO

abacavir results in decreased expression of TCF15 mRNA

NCBI chr 3:161,099,301...161,105,083
Ensembl chr 3:161,099,301...161,105,083

G

telomerase reverse transcriptase

decreases activity

ISO

abacavir results in decreased activity of TERT protein

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

tumor necrosis factor

multiple interactions

ISO

[HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

uncoupling protein 1

increases expression

ISO

abacavir results in increased expression of UCP1 mRNA

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

UNC homeobox

decreases expression

ISO

abacavir results in decreased expression of UNCX mRNA

NCBI chr12:20,206,604...20,211,125
Ensembl chr12:20,206,609...20,211,125

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects transport
multiple interactions

ISO

ABCG2 protein affects the transport of Acyclovir
tryptoquivaline inhibits the reaction [ABCG2 protein affects the transport of Acyclovir]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

actin alpha 2, smooth muscle

multiple interactions

ISO

Acyclovir inhibits the reaction [Oxidopamine results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

aquaporin 2

decreases expression

EXP

Acyclovir results in decreased expression of AQP2 protein

NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Acyclovir inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

multiple interactions

ISO

Acyclovir inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

3-hydroxyanthranilate 3,4-dioxygenase

decreases activity

ISO

Acyclovir results in decreased activity of HAAO protein

NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:16,598,087...16,617,356

G

indoleamine 2,3-dioxygenase 1

decreases activity

ISO

Acyclovir results in decreased activity of IDO1 protein

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

interleukin 12B

multiple interactions

ISO

Acyclovir inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 17A

multiple interactions

ISO

Acyclovir inhibits the reaction [Oxidopamine results in increased expression of IL17A protein]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 1 alpha

increases expression

ISO

Acyclovir results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

increases expression

ISO

Acyclovir results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 24

increases expression

ISO

Acyclovir results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

major histocompatibility complex, class I-related

affects expression

ISO

Acyclovir affects the expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

Acyclovir results in increased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

solute carrier family 12 member 1

decreases expression

EXP

Acyclovir results in decreased expression of SLC12A1 mRNA; Acyclovir results in decreased expression of SLC12A1 protein

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 17 member 1

decreases expression

EXP

Acyclovir results in decreased expression of SLC17A1 mRNA; Acyclovir results in decreased expression of SLC17A1 protein

NCBI chr17:41,647,332...41,683,078
Ensembl chr17:41,649,919...41,681,174

G

solute carrier family 7 member 11

increases expression

ISO

Acyclovir results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Acyclovir results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

tryptophan 2,3-dioxygenase

decreases activity

EXP

Acyclovir results in decreased activity of TDO2 protein

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586

G

tumor necrosis factor

multiple interactions

ISO

Acyclovir inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Acyclovir inhibits the reaction [Oxidopamine results in increased expression of TNF protein]

PMID:36416909 PMID:39617346

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions
affects transport

EXP

Calcitriol promotes the reaction [ABCB4 protein affects the transport of adefovir]

PMID:21240898 PMID:21341280

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 4

affects abundance
multiple interactions
decreases expression
increases export

ISO
EXP

ABCC4 protein affects the abundance of adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 protein
adefovir results in decreased expression of ABCC4 protein
ABCC4 protein results in increased export of adefovir

PMID:18364470 PMID:35114312

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

EXP

adefovir results in increased expression of ACTA2 protein
[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

angiotensinogen

multiple interactions

EXP

[Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

beta-2 microglobulin

increases secretion

EXP

adefovir results in increased secretion of B2M protein

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

calbindin 1

increases secretion

EXP

adefovir results in increased secretion of CALB1 protein

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160

G

chymase 1

increases secretion

EXP

adefovir results in increased secretion of CMA1 protein

NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133

G

cystatin C

multiple interactions
increases expression

EXP

[adefovir co-treated with Probenecid] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

hepatitis A virus cellular receptor 1

increases secretion

EXP

adefovir results in increased secretion of HAVCR1 protein

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

lipocalin 2

increases secretion

EXP

adefovir results in increased secretion of LCN2 protein

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

methylmalonyl-CoA mutase

affects expression
increases expression

ISO

adefovir affects the expression of MMUT mRNA mutant form; adefovir affects the expression of MMUT protein mutant form
adefovir results in increased expression of MMUT mRNA; adefovir results in increased expression of MMUT protein

PMID:19199343 PMID:19427250

NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:27,425,935...27,454,342

G

solute carrier family 22 member 6

increases uptake
multiple interactions
decreases expression
affects response to substance
increases response to substance

EXP
ISO

SLC22A6 protein results in increased uptake of adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein]
adefovir results in decreased expression of SLC22A6 protein
SLC22A6 protein affects the susceptibility to adefovir
adefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; quercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir

PMID:16857889 PMID:21244849 PMID:23856525 PMID:25448811 PMID:35114312 More...

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

increases response to substance
multiple interactions
decreases expression

ISO
EXP

SLC22A8 protein results in increased susceptibility to adefovir
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]
adefovir results in decreased expression of SLC22A8 protein

PMID:25448811 PMID:35114312 PMID:39481674

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

secreted phosphoprotein 1

increases secretion

EXP

adefovir results in increased secretion of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

transforming growth factor, beta 1

increases expression
multiple interactions

EXP

adefovir results in increased expression of TGFB1 protein
[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

adefovir pivoxil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects activity

ISO

adefovir dipivoxil affects the activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

adenylate kinase 4

increases expression

ISO

adefovir dipivoxil results in increased expression of AK4 mRNA

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

aldo-keto reductase family 1, member C2

decreases expression

ISO

adefovir dipivoxil results in decreased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

adefovir dipivoxil results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

ALS2 C-terminal like

increases expression

ISO

adefovir dipivoxil results in increased expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843

G

angiopoietin-like 4

increases expression

ISO

adefovir dipivoxil results in increased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

ISO

adefovir dipivoxil results in decreased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

ATPase family, AAA domain containing 2

increases expression

ISO

adefovir dipivoxil results in increased expression of ATAD2 mRNA

NCBI chr 7:91,523,626...91,566,238
Ensembl chr 7:91,523,626...91,566,238

G

activating transcription factor 3

increases expression

ISO

adefovir dipivoxil results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

aurora kinase B

increases expression

ISO

adefovir dipivoxil results in increased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

Axl receptor tyrosine kinase

increases expression

ISO

adefovir dipivoxil results in increased expression of AXL mRNA

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

adefovir dipivoxil results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCAR3 adaptor protein, NSP family member

increases expression

ISO

adefovir dipivoxil results in increased expression of BCAR3 mRNA

NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302

G

BEN domain containing 5

decreases expression

ISO

adefovir dipivoxil results in decreased expression of BEND5 mRNA

NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906

G

Bcl2 modifying factor

decreases expression

ISO

adefovir dipivoxil results in decreased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

BTG anti-proliferation factor 2

increases expression

ISO

adefovir dipivoxil results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

cyclin E2

increases expression

ISO

adefovir dipivoxil results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin-dependent kinase 6

increases expression

ISO

adefovir dipivoxil results in increased expression of CDK6 mRNA

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

adefovir dipivoxil results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

carboxymethylenebutenolidase homolog

increases expression

ISO

adefovir dipivoxil results in increased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

cochlin

increases expression

ISO

adefovir dipivoxil results in increased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

collagen type IV alpha 1 chain

decreases expression

ISO

adefovir dipivoxil results in decreased expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

cystathionine gamma-lyase

decreases expression

ISO

adefovir dipivoxil results in decreased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cathepsin C

decreases expression

ISO

adefovir dipivoxil results in decreased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

ISO

adefovir dipivoxil results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

adefovir dipivoxil results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

damage specific DNA binding protein 2

increases expression

ISO

adefovir dipivoxil results in increased expression of DDB2 mRNA

NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066

G

diacylglycerol kinase, alpha

increases expression

ISO

adefovir dipivoxil results in increased expression of DGKA mRNA

NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569

G

DLG associated protein 5

increases expression

ISO

adefovir dipivoxil results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

distal-less homeobox 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of DLX1 mRNA

NCBI chr 3:76,763,864...76,768,454
Ensembl chr 3:76,763,500...76,768,447

G

dynein axonemal intermediate chain 3

increases expression

ISO

adefovir dipivoxil results in increased expression of DNAI3 mRNA

NCBI chr 2:237,608,202...237,666,465
Ensembl chr 2:237,604,068...237,666,465

G

dihydropyrimidinase-like 3

increases expression

ISO

adefovir dipivoxil results in increased expression of DPYSL3 mRNA

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

ephrin A1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

ISO

adefovir dipivoxil results in increased expression of ERO1A mRNA

NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039

G

Fas cell surface death receptor

increases expression

ISO

adefovir dipivoxil results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box protein 22

increases expression

ISO

adefovir dipivoxil results in increased expression of FBXO22 mRNA

NCBI chr 8:64,476,034...64,492,063
Ensembl chr 8:64,475,957...64,492,062

G

GABA type A receptor associated protein like 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578

G

growth arrest and DNA-damage-inducible, alpha

increases expression

ISO

adefovir dipivoxil results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

polypeptide N-acetylgalactosaminyltransferase 16

decreases expression

ISO

adefovir dipivoxil results in decreased expression of GALNT16 mRNA

NCBI chr 6:105,900,987...105,982,039
Ensembl chr 6:105,901,153...105,991,350

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

ISO

adefovir dipivoxil results in increased expression of GCNT3 mRNA

NCBI chr 8:79,570,081...79,577,389
Ensembl chr 8:79,566,753...79,581,595

G

growth differentiation factor 15

increases expression

ISO

adefovir dipivoxil results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glutamic-oxaloacetic transaminase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

G protein-coupled receptor 87

increases expression

ISO

adefovir dipivoxil results in increased expression of GPR87 mRNA

NCBI chr 2:145,589,630...145,608,094
Ensembl chr 2:145,589,569...145,604,442

G

H1.2 linker histone, cluster member

increases expression

ISO

adefovir dipivoxil results in increased expression of H1-2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

heme oxygenase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 1B

decreases expression

ISO

adefovir dipivoxil results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

interferon gamma

multiple interactions

ISO

adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 19

increases secretion

ISO

adefovir dipivoxil results in increased secretion of IL19 protein

NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714

G

lysine acetyltransferase 6B

decreases expression

ISO

adefovir dipivoxil results in decreased expression of KAT6B mRNA

NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343

G

lysine demethylase 3A

decreases expression

ISO

adefovir dipivoxil results in decreased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

keratin 15

increases expression

ISO

adefovir dipivoxil results in increased expression of KRT15 mRNA

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142

G

laminin subunit alpha 3

increases expression

ISO

adefovir dipivoxil results in increased expression of LAMA3 mRNA

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

lipocalin 2

increases secretion

ISO

adefovir dipivoxil results in increased secretion of LCN2 protein

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

mitogen-activated protein kinase kinase kinase 8

increases expression

ISO

adefovir dipivoxil results in increased expression of MAP3K8 mRNA

NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452

G

MDM2 proto-oncogene

increases expression

ISO

adefovir dipivoxil results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MAX interactor 1, dimerization protein

decreases expression

ISO

adefovir dipivoxil results in decreased expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036

G

non-SMC condensin I complex, subunit D2

increases expression

ISO

adefovir dipivoxil results in increased expression of NCAPD2 mRNA

NCBI chr 4:159,655,051...159,677,938
Ensembl chr 4:159,655,051...159,677,938

G

ninjurin 1

increases expression

ISO

adefovir dipivoxil results in increased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

nitric oxide synthase 2

multiple interactions

ISO

adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

neuronal regeneration related protein

decreases expression

ISO

adefovir dipivoxil results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

nucleoside-triphosphatase, cancer-related

increases expression

ISO

adefovir dipivoxil results in increased expression of NTPCR mRNA

NCBI chr19:70,598,816...70,612,580
Ensembl chr19:70,593,274...70,613,197

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

pantothenate kinase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of PANK1 mRNA

NCBI chr 1:241,737,371...241,808,126
Ensembl chr 1:241,741,083...241,807,824

G

protein disulfide isomerase family A, member 5

increases expression

ISO

adefovir dipivoxil results in increased expression of PDIA5 mRNA

NCBI chr11:78,777,436...78,892,370
Ensembl chr11:78,777,419...78,864,329

G

PDZ and LIM domain 1

increases expression

ISO

adefovir dipivoxil results in increased expression of PDLIM1 mRNA

NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379

G

progesterone receptor

multiple interactions

ISO

adefovir dipivoxil binds to and results in decreased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

pleckstrin homology-like domain, family A, member 3

increases expression

ISO

adefovir dipivoxil results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

p53-induced death domain protein 1

increases expression

ISO

adefovir dipivoxil results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

pirin

increases expression

ISO

adefovir dipivoxil results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

plectin

increases expression

ISO

adefovir dipivoxil results in increased expression of PLEC mRNA

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

adefovir dipivoxil results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

peroxisome proliferator-activated receptor gamma

affects activity

ISO

adefovir dipivoxil affects the activity of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

ISO

adefovir dipivoxil results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

protein regulator of cytokinesis 1

increases expression

ISO

adefovir dipivoxil results in increased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

PR/SET domain 1

increases expression

ISO

adefovir dipivoxil results in increased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

protein kinase AMP-activated non-catalytic subunit beta 2

decreases expression

ISO

adefovir dipivoxil results in decreased expression of PRKAB2 mRNA

NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608

G

phosphoserine aminotransferase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

retinoic acid receptor, alpha

decreases expression

ISO

adefovir dipivoxil results in decreased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

ribosomal protein S27-like

increases expression

ISO

adefovir dipivoxil results in increased expression of RPS27L mRNA

NCBI chr 8:76,443,658...76,448,593
Ensembl chr12:33,713,661...33,714,130
Ensembl chr 8:33,713,661...33,714,130

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

ISO

adefovir dipivoxil results in increased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

serpin family B member 5

increases expression

ISO

adefovir dipivoxil results in increased expression of SERPINB5 mRNA

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400

G

sestrin 1

increases expression

ISO

adefovir dipivoxil results in increased expression of SESN1 mRNA

NCBI chr20:46,876,918...46,970,010
Ensembl chr20:46,876,895...46,970,010

G

stratifin

increases expression

ISO

adefovir dipivoxil results in increased expression of SFN mRNA

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

SH3 domain and tetratricopeptide repeats 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of SH3TC1 mRNA

NCBI chr14:79,230,322...79,274,622
Ensembl chr14:79,230,371...79,274,620

G

solute carrier family 27 member 2

decreases expression

ISO

adefovir dipivoxil results in decreased expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 6 member 9

decreases expression

ISO

adefovir dipivoxil results in decreased expression of SLC6A9 mRNA

NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172

G

solute carrier organic anion transporter family, member 2b1

increases expression

ISO

adefovir dipivoxil results in increased expression of SLCO2B1 mRNA

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279

G

small ArfGAP 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of SMAP1 mRNA

NCBI chr 9:33,746,489...33,838,488
Ensembl chr 9:33,746,489...33,838,734

G

sulfatase 2

increases expression

ISO

adefovir dipivoxil results in increased expression of SULF2 mRNA

NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651

G

thyroid hormone receptor alpha

multiple interactions

ISO

adefovir dipivoxil binds to and results in decreased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

TP53 induced glycolysis regulatory phosphatase

increases expression

ISO

adefovir dipivoxil results in increased expression of TIGAR mRNA

NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:161,613,306...161,632,229

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

ISO

adefovir dipivoxil results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

TNF superfamily member 9

increases expression

ISO

adefovir dipivoxil results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339

G

tumor protein p53

affects activity

ISO

adefovir dipivoxil affects the activity of TP53 protein

PMID:25596134 PMID:35435491

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible nuclear protein 1

increases expression

ISO

adefovir dipivoxil results in increased expression of TP53INP1 mRNA

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484

G

TRAF type zinc finger domain containing 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of TRAFD1 mRNA

NCBI chr12:40,826,251...40,840,169
Ensembl chr12:40,825,851...40,841,320

G

TP53 regulated inhibitor of apoptosis 1

increases expression

ISO

adefovir dipivoxil results in increased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766

G

ubiquitin-conjugating enzyme E2O

decreases expression

ISO

adefovir dipivoxil results in decreased expression of UBE2O mRNA

NCBI chr10:102,264,418...102,311,578
Ensembl chr10:102,264,418...102,311,549

G

tyrosyl-tRNA synthetase 1

decreases expression

ISO

adefovir dipivoxil results in decreased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377

G

zinc finger, matrin type 3

increases expression

ISO

adefovir dipivoxil results in increased expression of ZMAT3 mRNA

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:117,034,517...117,065,294

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

multiple interactions

EXP

[Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

interferon, alpha-inducible protein 27

increases expression

ISO

Amantadine results in increased expression of IFI27 mRNA

NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781

G

interferon alpha and beta receptor subunit 1

affects expression

ISO

Amantadine affects the expression of IFNAR1 mRNA

NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205

G

Janus kinase 1

increases expression

ISO

Amantadine results in increased expression of JAK1 protein

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Amantadine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

microtubule-associated protein 2

decreases expression

ISO

Amantadine results in decreased expression of MAP2 mRNA

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

2'-5' oligoadenylate synthetase 2

increases expression

ISO

Amantadine results in increased expression of OAS2 mRNA

NCBI chr12:41,464,568...41,492,036
Ensembl chr12:41,467,315...41,495,881

G

solute carrier family 47 member 1

multiple interactions

ISO

Amantadine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096

G

solute carrier family 47 member 2

multiple interactions

ISO

Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425

G

signal transducer and activator of transcription 1

multiple interactions

ISO

[Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

tyrosyl-DNA phosphodiesterase 1

decreases activity

ISO

Amantadine analog results in decreased activity of TDP1 protein

NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:124,881,574...124,960,642

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

ISO

amprenavir results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases transport
multiple interactions
affects binding

ISO

ABCB1 protein results in increased transport of amprenavir
[Elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of amprenavir
amprenavir binds to ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

C-C motif chemokine ligand 2

increases expression

ISO

amprenavir results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases expression

ISO

amprenavir results in increased expression of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

amprenavir results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of amprenavir]

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

multiple interactions

ISO

[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]; [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATR serine/threonine kinase

multiple interactions

ISO

[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased expression of BSCL2 mRNA]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

BSCL2 lipid droplet biogenesis associated, seipin

multiple interactions
increases expression

ISO

[7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased expression of BSCL2 mRNA]

NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536

G

cyclin A2

increases expression

ISO

Aphidicolin results in increased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

checkpoint kinase 1

multiple interactions

ISO

[7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of CHEK1 protein]

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions

ISO

Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
[7-hydroxystaurosporine results in decreased activity of [CHEK1 protein co-treated with BSCL2 protein]] inhibits the reaction [Aphidicolin results in increased expression of CHEK2 mRNA]

PMID:18158334 PMID:22003191

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

cytochrome P450, family 26, subfamily a, polypeptide 1

increases expression

ISO

Aphidicolin results in increased expression of CYP26A1 mRNA

NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657

G

fibroblast growth factor 8

increases expression

ISO

Aphidicolin results in increased expression of FGF8 mRNA

NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:254,533,504...254,539,605

G

H2A.X variant histone

multiple interactions

ISO

Aphidicolin inhibits the reaction [Docetaxel results in increased expression of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

homeo box B9

decreases expression

ISO

Aphidicolin results in decreased expression of HOXB9 mRNA

NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,733,658...81,738,872

G

homeo box C6

decreases expression

ISO

Aphidicolin results in decreased expression of HOXC6 mRNA

NCBI chr 7:136,013,679...136,051,601
Ensembl chr 7:136,024,961...136,027,365

G

DNA polymerase alpha 1, catalytic subunit

decreases activity

ISO
EXP

Aphidicolin results in decreased activity of POLA1 protein

NCBI chr X:62,028,475...62,342,455
Ensembl chr X:62,028,476...62,342,355

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions

ISO

Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

retinoid X receptor alpha

increases expression

ISO

Aphidicolin results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

sulfiredoxin 1

increases expression

ISO

Aphidicolin results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

T-box transcription factor 6

decreases expression

ISO

Aphidicolin results in decreased expression of TBX6 mRNA

NCBI chr 1:190,818,397...190,823,824
Ensembl chr 1:190,819,229...190,823,138

G

TNF receptor superfamily member 8

increases expression

ISO

Aphidicolin results in increased expression of TNFRSF8 protein

NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:162,406,387...162,451,620

G

tumor protein p53

multiple interactions

ISO

[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]; [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tripartite motif-containing 28

multiple interactions

ISO

[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

Wnt family member 3A

decreases expression

ISO

Aphidicolin results in decreased expression of WNT3A mRNA

NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919

G

X-ray repair cross complementing 4

decreases response to substance

ISO

XRCC4 results in decreased susceptibility to Aphidicolin

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

atazanavir sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

ISO

Atazanavir Sulfate results in decreased activity of ABCB11 protein
Atazanavir Sulfate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases transport
multiple interactions

ISO

ABCB1 protein results in increased transport of Atazanavir Sulfate
[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ABCB1 mRNA

PMID:29859254 PMID:33819548

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ABCB4 mRNA

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 2

decreases expression

ISO

Atazanavir Sulfate results in decreased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

decreases expression

ISO

Atazanavir Sulfate results in decreased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of ABCG2 mRNA

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

ATP binding cassette subfamily G member 5

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ABCG5 mRNA

NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376

G

ATP binding cassette subfamily G member 8

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ABCG8 mRNA

NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

adhesion G protein-coupled receptor G1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of ADGRG1 mRNA

NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,010,031...10,047,124

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ADH1C mRNA

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

alcohol dehydrogenase 4 (class II), pi polypeptide

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ADH4 mRNA

NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879

G

alcohol dehydrogenase 6 (class V)

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ADH6 mRNA

NCBI chr 2:229,576,612...229,608,359
Ensembl chr 2:229,576,636...229,607,914

G

aldo-keto reductase family 1, member D1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of AKR1D1 mRNA

NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:67,120,024...67,154,540

G

aldo-keto reductase family 7 member A3

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of AKR7A3 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR7A3 mRNA

NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153

G

albumin

affects binding
multiple interactions

ISO

Atazanavir Sulfate binds to ALB protein
[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ALB mRNA

PMID:15814459 PMID:16336266 PMID:33819548

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alkaline phosphatase, placental

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ALPP mRNA

NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:95,213,374...95,219,451

G

adenosine monophosphate deaminase 3

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of AMPD3 mRNA

NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:174,294,867...174,364,608

G

apolipoprotein A1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of APOA1 mRNA

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

activating transcription factor 4

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATF4 mRNA
Atazanavir Sulfate results in increased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATF6 mRNA
Atazanavir Sulfate results in increased expression of ATF6 mRNA

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

autophagy related 7

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of ATG7 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ATG7 mRNA

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

ATPase phospholipid transporting 8B1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of ATP8B1 mRNA

NCBI chr18:60,286,605...60,427,862
Ensembl chr18:60,288,464...60,427,027

G

bile acid CoA:amino acid N-acyltransferase

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of BAAT mRNA

NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181

G

Bcl2-like 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

catalase

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of CAT mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

increases expression

ISO

Atazanavir Sulfate results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases expression

ISO

Atazanavir Sulfate results in increased expression of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

chitinase 3 like 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CHI3L1 mRNA

NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825

G

colony stimulating factor 1

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of CSF1 mRNA
Atazanavir Sulfate results in increased expression of CSF1 mRNA

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

catenin beta 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CTNNB1 mRNA

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cortactin

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of CTTN mRNA

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

CYLD lysine 63 deubiquitinase

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of CYLD mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP1A2 mRNA

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP27A1 mRNA

NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of CYP2B6 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP2B6 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP2C18 mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP2C19 mRNA

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of CYP3A4 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP3A5 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of CYP7A1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 7 subfamily B member 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of DDIT3 mRNA
Atazanavir Sulfate results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DnaJ heat shock protein family (Hsp40) member B9

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

DnaJ heat shock protein family (Hsp40) member C10

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of DNAJC10 mRNA
Atazanavir Sulfate results in increased expression of DNAJC10 mRNA

NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368

G

DnaJ heat shock protein family (Hsp40) member C12

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of DNAJC12 mRNA

NCBI chr20:25,245,475...25,266,238
Ensembl chr20:25,222,298...25,266,251

G

DnaJ heat shock protein family (Hsp40) member C9

increases expression

ISO

Atazanavir Sulfate results in increased expression of DNAJC9 mRNA

NCBI chr15:3,970,843...4,003,009
Ensembl chr15:3,970,114...3,977,304

G

epoxide hydrolase 1

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of EPHX1 mRNA
Atazanavir Sulfate results in decreased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

FKBP prolyl isomerase 5

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of FKBP5 mRNA
Atazanavir Sulfate results in decreased expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

ISO

Atazanavir Sulfate results in decreased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of FOSL1 mRNA
Atazanavir Sulfate results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

gamma-glutamyltransferase 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of GGT1 mRNA

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, beta 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of GJB1 mRNA

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

glycerol kinase

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of GK mRNA

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

G protein-coupled receptor, class C, group 5, member B

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of GPRC5B mRNA

NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:182,748,247...182,772,757

G

glutathione peroxidase 2

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of GPX2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of GPX2 mRNA
Atazanavir Sulfate results in decreased expression of GPX2 mRNA

PMID:32152650 PMID:33819548

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione S-transferase alpha 1

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of GSTA1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of GSTA1 mRNA

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase mu 4

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of GSTM4 mRNA

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:198,358,744...198,373,638

G

2-hydroxyacyl-CoA lyase 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of HACL1 mRNA

NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,833,268...6,869,410

G

hepatocyte growth factor

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of HGF mRNA

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Atazanavir Sulfate promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]
Atazanavir Sulfate results in increased expression of HMOX1 mRNA; Atazanavir Sulfate results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hemopexin

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of HPX mRNA

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156

G

heat shock protein family A (Hsp70) member 5

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of HSPA5 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

increases expression

ISO

Atazanavir Sulfate results in increased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

immediate early response 3

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of IER3 mRNA

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

interferon, alpha-inducible protein 27

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of IFI27 mRNA

NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781

G

insulin-like growth factor binding protein 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of IGFBP1 mRNA

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

interleukin 6

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

kynureninase

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

lipopolysaccharide binding protein

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of LBP mRNA

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

low density lipoprotein receptor

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

lipase C, hepatic type

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lymphocyte antigen 96

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of LY96 mRNA

NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816

G

MAF bZIP transcription factor F

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of MAFF mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAFF mRNA

NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:112,791,416...112,804,147

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAP1LC3B mRNA
Atazanavir Sulfate results in increased expression of MAP1LC3B mRNA

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen-activated protein kinase kinase 6

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of MAP2K6 mRNA
Atazanavir Sulfate results in decreased expression of MAP2K6 mRNA

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

MAPK activated protein kinase 3

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of MAPKAPK3 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MAPKAPK3 mRNA

NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228

G

mixed lineage kinase domain like pseudokinase

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of MLKL mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of MLKL mRNA
Atazanavir Sulfate results in increased expression of MLKL mRNA

PMID:32152650 PMID:33819548

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

methylmalonyl-CoA mutase

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of MMUT mRNA

NCBI chr 9:27,425,935...27,454,202
Ensembl chr 9:27,425,935...27,454,342

G

microsomal triglyceride transfer protein

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of MTTP mRNA

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

nuclear transcription factor, X-box binding-like 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of NFXL1 mRNA

NCBI chr14:35,980,058...36,021,478
Ensembl chr14:35,980,057...36,023,281

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of NR1H3 mRNA

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group H, member 4

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of NR1H4 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1H4 mRNA

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

nuclear receptor subfamily 1, group I, member 2

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of NR1I2 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1I2 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of NR1I3 mRNA
Atazanavir Sulfate results in decreased expression of NR1I3 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

phenylalanine hydroxylase

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of PAH mRNA

NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of PIK3C2G mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3C2G mRNA

NCBI chr 4:174,215,527...174,583,378
Ensembl chr 4:174,215,527...174,581,705

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of PIK3R1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

paraoxonase 1

decreases activity

EXP

Atazanavir Sulfate results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

protein phosphatase 1, regulatory subunit 3C

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of PPP1R3C mRNA

NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:243,871,704...243,878,835

G

RAS like proto-oncogene A

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of RALA mRNA

NCBI chr17:51,787,682...51,840,738
Ensembl chr17:51,787,699...51,840,733

G

receptor accessory protein 5

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of REEP5 mRNA

NCBI chr18:26,219,528...26,257,505
Ensembl chr18:26,219,530...26,250,660

G

receptor interacting serine/threonine kinase 1

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of RIPK1 mRNA

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

sterol carrier protein 2

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SCP2 mRNA

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

syndecan 2

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SDC2 mRNA

NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294

G

serpin family E member 1

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of SERPINE1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

SH3 domain -containing GRB2-like endophilin B1

increases expression
multiple interactions

ISO

Atazanavir Sulfate results in increased expression of SH3GLB1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SH3GLB1 mRNA

NCBI chr 2:236,411,194...236,445,225
Ensembl chr 2:236,410,436...236,445,140

G

solute carrier family 10 member 1

multiple interactions
decreases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of SLC10A1 mRNA
Atazanavir Sulfate results in decreased expression of SLC10A1 mRNA

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 17 member 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SLC17A1 mRNA

NCBI chr17:41,647,332...41,683,078
Ensembl chr17:41,649,919...41,681,174

G

solute carrier family 22 member 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SLC22A1 mRNA

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 51 member A

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SLC51A mRNA

NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539

G

SLC51 subunit beta

multiple interactions

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SLC51B mRNA

NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:74,827,047...74,835,109

G

superoxide dismutase 2

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SOD2 mRNA
Atazanavir Sulfate results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sortilin related receptor 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

sequestosome 1

multiple interactions
increases expression

ISO

[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of SQSTM1 mRNA
Atazanavir Sulfate results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

signal recognition particle 72

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of SRP72 mRNA

NCBI chr14:31,522,424...31,549,978
Ensembl chr14:31,522,963...31,550,151

G

sulfotransferase family 2A member 1

decreases expression
multiple interactions

ISO

Atazanavir Sulfate results in decreased expression of SULT2A1 mRNA
[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

tissue factor pathway inhibitor

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of TFPI mRNA

NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:89,939,868...89,980,742

G

toll-like receptor 4

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of TLR4 mRNA

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

TNF receptor superfamily member 10b

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of TNFRSF10A mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF superfamily member 10

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 11

multiple interactions

ISO

[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate] results in increased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

cidofovir anhydrous

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 6

increases expression

ISO

Cidofovir results in increased expression of ABCB6 mRNA

NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526

G

ATP binding cassette subfamily B member 9

increases expression

ISO

Cidofovir results in increased expression of ABCB9 mRNA

NCBI chr12:38,146,659...38,192,862
Ensembl chr12:38,159,904...38,192,860

G

ATP binding cassette subfamily G member 1

decreases expression

ISO

Cidofovir results in decreased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

abhydrolase domain containing 4, N-acyl phospholipase B

increases expression

ISO

Cidofovir results in increased expression of ABHD4 mRNA

NCBI chr15:31,674,090...31,686,051
Ensembl chr15:31,674,143...31,687,007

G

acyl-CoA synthetase long-chain family member 1

decreases expression

ISO

Cidofovir results in decreased expression of ACSL1 mRNA

NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023

G

agrin

increases expression

ISO

Cidofovir results in increased expression of AGRN mRNA

NCBI chr 5:172,031,528...172,064,429
Ensembl chr 5:172,031,528...172,064,539

G

aryl hydrocarbon receptor

affects activity

ISO

Cidofovir affects the activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

adenylate kinase 3

increases expression

ISO

Cidofovir results in increased expression of AK3 mRNA

NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:236,151,012...236,178,183

G

adenylate kinase 4

increases expression

ISO

Cidofovir results in increased expression of AK4 mRNA

NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:121,154,572...121,214,401

G

aldo-keto reductase family 1, member C2

affects expression

ISO

Cidofovir affects the expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldehyde dehydrogenase 18 family, member A1

affects expression

ISO

Cidofovir affects the expression of ALDH18A1 mRNA

NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:249,325,082...249,357,383

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

Cidofovir results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldolase, fructose-bisphosphate A

increases expression

ISO

Cidofovir results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

ALS2 C-terminal like

affects expression

ISO

Cidofovir affects the expression of ALS2CL mRNA

NCBI chr 8:119,746,498...119,762,824
Ensembl chr 8:119,743,248...119,762,843

G

angiopoietin-like 4

increases expression

ISO

Cidofovir results in increased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

ankyrin repeat family A member 2

decreases expression

ISO

Cidofovir results in decreased expression of ANKRA2 mRNA

NCBI chr 2:31,347,158...31,358,002
Ensembl chr 2:31,347,090...31,364,394

G

Rho guanine nucleotide exchange factor 10

decreases expression

ISO

Cidofovir results in decreased expression of ARHGEF10 mRNA

NCBI chr16:81,349,429...81,440,439
Ensembl chr16:81,349,429...81,440,054

G

allregulin

decreases expression

ISO

Cidofovir results in decreased expression of ARLN mRNA

NCBI chr 2:213,740,519...213,742,279
Ensembl chr 2:213,740,525...213,742,952

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

Cidofovir results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

ATPase family, AAA domain containing 2

increases expression

ISO

Cidofovir results in increased expression of ATAD2 mRNA

NCBI chr 7:91,523,626...91,566,238
Ensembl chr 7:91,523,626...91,566,238

G

activating transcription factor 3

increases expression

ISO

Cidofovir results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

affects activity

ISO

Cidofovir affects the activity of ATF4 protein

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

atos homolog A

decreases expression

ISO

Cidofovir results in decreased expression of ATOSA mRNA

NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:84,575,370...84,653,091

G

ataxin 1

decreases expression

ISO

Cidofovir results in decreased expression of ATXN1 mRNA

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790

G

aurora kinase B

increases expression

ISO

Cidofovir results in increased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

Axl receptor tyrosine kinase

increases expression

ISO

Cidofovir results in increased expression of AXL mRNA

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Cidofovir results in increased expression of BAX; Cidofovir results in increased expression of BAX mRNA

PMID:12700662 PMID:25596134

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

increases expression

ISO

Cidofovir results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

branched chain amino acid transaminase 2

increases expression

ISO

Cidofovir results in increased expression of BCAT2 mRNA

NCBI chr 1:105,175,157...105,196,474
Ensembl chr 1:105,176,977...105,196,463

G

BCL2, apoptosis regulator

decreases expression

ISO

Cidofovir results in decreased expression of BCL2

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BEN domain containing 5

affects expression

ISO

Cidofovir affects the expression of BEND5 mRNA

NCBI chr 5:131,519,214...131,565,228
Ensembl chr 5:131,519,214...131,762,906

G

Bcl2 modifying factor

increases expression

ISO

Cidofovir results in increased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

bromodomain containing 2

decreases expression

ISO

Cidofovir results in decreased expression of BRD2 mRNA

NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,951...4,737,290

G

BTG anti-proliferation factor 2

increases expression

ISO

Cidofovir results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

calcium/calmodulin-dependent protein kinase kinase 2

increases expression

ISO

Cidofovir results in increased expression of CAMKK2 mRNA

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:39,451,834...39,514,964

G

cysteinyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caspase 3

decreases activity

ISO

Cidofovir results in decreased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

coiled-coil domain containing 90B

decreases expression

ISO

Cidofovir results in decreased expression of CCDC90B mRNA

NCBI chr 1:156,045,192...156,058,750
Ensembl chr 1:156,045,138...156,061,403

G

cyclin E2

increases expression

ISO

Cidofovir results in increased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin G2

decreases expression

ISO

Cidofovir results in decreased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Cidofovir results in increased expression of CDKN1A mRNA; Cidofovir results in increased expression of CDKN1A protein

PMID:11697818 PMID:25596134

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

ceramide synthase 5

increases expression

ISO

Cidofovir results in increased expression of CERS5 mRNA

NCBI chr 7:132,738,834...132,776,920
Ensembl chr 7:132,738,834...132,776,786

G

CAP-GLY domain containing linker protein family, member 4

decreases expression

ISO

Cidofovir results in decreased expression of CLIP4 mRNA

NCBI chr 6:29,359,628...29,449,365
NCBI chr 6:29,349,245...29,351,890
Ensembl chr 6:29,348,918...29,449,271

G

carboxymethylenebutenolidase homolog

increases expression

ISO

Cidofovir results in increased expression of CMBL mRNA

NCBI chr 2:84,280,128...84,301,878
Ensembl chr 2:84,242,512...84,301,880

G

cytidine/uridine monophosphate kinase 1

increases phosphorylation

ISO

CMPK1 protein results in increased phosphorylation of Cidofovir

NCBI chr 5:133,717,073...133,744,623
Ensembl chr 5:133,717,086...133,744,596

G

cochlin

increases expression

ISO

Cidofovir results in increased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

collagen type IV alpha 1 chain

affects expression

ISO

Cidofovir affects the expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

ceruloplasmin

increases expression

ISO

Cidofovir results in increased expression of CP mRNA

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087

G

CTD phosphatase subunit 1

decreases expression

ISO

Cidofovir results in decreased expression of CTDP1 mRNA

NCBI chr18:76,129,243...76,193,404
Ensembl chr18:76,129,243...76,190,578

G

cathepsin C

increases expression

ISO

Cidofovir results in increased expression of CTSC mRNA

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082

G

cortactin

increases expression

ISO

Cidofovir results in increased expression of CTTN mRNA

NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:209,029,048...209,058,211

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

ISO

Cidofovir results in decreased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

ISO

Cidofovir results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

damage specific DNA binding protein 2

increases expression

ISO

Cidofovir results in increased expression of DDB2 mRNA

NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066

G

DNA-damage inducible transcript 3

decreases expression

ISO

Cidofovir results in decreased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

affects expression

ISO

Cidofovir affects the expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DEAD-box helicase 17

decreases expression

ISO

Cidofovir results in decreased expression of DDX17 mRNA

NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:112,971,523...112,989,747

G

diacylglycerol kinase, alpha

increases expression

ISO

Cidofovir results in increased expression of DGKA mRNA

NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,733,248...1,759,569

G

DEAH-box helicase 37

decreases expression

ISO

Cidofovir results in decreased expression of DHX37 mRNA

NCBI chr12:36,856,119...36,876,245
Ensembl chr12:36,849,701...36,876,240

G

DLG associated protein 5

increases expression

ISO

Cidofovir results in increased expression of DLGAP5 mRNA

NCBI chr15:23,113,678...23,144,281
Ensembl chr15:23,113,678...23,144,176

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

ISO

Cidofovir results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

dolichyl-phosphate mannosyltransferase subunit 3, regulatory

increases expression

ISO

Cidofovir results in increased expression of DPM3 mRNA

NCBI chr 2:176,974,290...176,974,805
Ensembl chr15:52,612,418...52,612,696

G

dihydropyrimidinase-like 3

increases expression

ISO

Cidofovir results in increased expression of DPYSL3 mRNA

NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152

G

dual specificity phosphatase 22

increases expression

ISO

Cidofovir results in increased expression of DUSP22 mRNA

NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,989,637...34,039,895

G

dual specificity phosphatase 5

increases expression

ISO

Cidofovir results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

ephrin A1

decreases expression

ISO

Cidofovir results in decreased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

eukaryotic translation initiation factor 3, subunit C

decreases expression

ISO

Cidofovir results in decreased expression of EIF3C mRNA

NCBI chr 1:190,565,183...190,583,067
Ensembl chr 1:190,565,184...190,583,067

G

ETS transcription factor ELK4

decreases expression

ISO

Cidofovir results in decreased expression of ELK4 mRNA

NCBI chr13:46,004,145...46,027,206
Ensembl chr13:46,004,182...46,027,199

G

enolase 2

increases expression

ISO

Cidofovir results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

enolase superfamily member 1

decreases expression

ISO

Cidofovir results in decreased expression of ENOSF1 mRNA

G

ectonucleoside triphosphate diphosphohydrolase 7

increases expression

ISO

Cidofovir results in increased expression of ENTPD7 mRNA

NCBI chr 1:252,508,594...252,550,269
Ensembl chr 1:252,508,594...252,550,269

G

E1A binding protein p400

decreases expression

ISO

Cidofovir results in decreased expression of EP400 mRNA

NCBI chr12:51,551,665...51,658,635
Ensembl chr12:51,551,695...51,658,634

G

glutamyl-prolyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of EPRS1 mRNA

NCBI chr13:99,431,955...99,503,510
Ensembl chr13:99,433,130...99,503,509

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

ISO

Cidofovir results in increased expression of ERO1A mRNA

NCBI chr15:20,974,771...21,010,170
Ensembl chr15:20,972,679...21,018,039

G

family with sequence similarity 162, member A

decreases expression

ISO

Cidofovir results in decreased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

family with sequence similarity 210, member A

increases expression

ISO

Cidofovir results in increased expression of FAM210A mRNA

NCBI chr18:64,116,274...64,155,971
Ensembl chr18:64,116,274...64,155,949

G

family with sequence similarity 210, member B

increases expression

ISO

Cidofovir results in increased expression of FAM210B mRNA

NCBI chr 3:181,536,665...181,546,830
Ensembl chr 3:181,536,673...181,546,834

G

family with sequence similarity 89, member A

increases expression

ISO

Cidofovir results in increased expression of FAM89A mRNA

NCBI chr19:69,607,391...69,620,019
Ensembl chr19:69,607,391...69,620,019

G

Fas cell surface death receptor

affects expression

ISO

Cidofovir affects the expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box protein 22

increases expression

ISO

Cidofovir results in increased expression of FBXO22 mRNA

NCBI chr 8:64,476,034...64,492,063
Ensembl chr 8:64,475,957...64,492,062

G

F-box protein 30

decreases expression

ISO

Cidofovir results in decreased expression of FBXO30 mRNA

NCBI chr 1:7,475,636...7,491,719
Ensembl chr 1:7,475,575...7,493,199

G

ferrochelatase

decreases expression

ISO

Cidofovir results in decreased expression of FECH mRNA

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546

G

FLVCR choline and putative heme transporter 2

affects expression

ISO

Cidofovir affects the expression of FLVCR2 mRNA

NCBI chr 6:111,139,352...111,203,345
Ensembl chr 6:111,139,295...111,203,345

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

Cidofovir results in increased expression of FOSL1 mRNA

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

decreases expression

ISO

Cidofovir results in decreased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

FRAS1 related extracellular matrix 2

decreases expression

ISO

Cidofovir results in decreased expression of FREM2 mRNA

NCBI chr 2:139,753,055...139,891,046
Ensembl chr 2:139,753,055...139,891,046

G

GABA type A receptor associated protein like 1

decreases expression

ISO

Cidofovir results in decreased expression of GABARAPL1 mRNA

NCBI chr 4:164,666,332...164,675,474
Ensembl chr 4:164,666,246...164,674,578

G

growth arrest and DNA-damage-inducible, alpha

affects expression

ISO

Cidofovir affects the expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glycyl-tRNA synthetase 1

increases expression

ISO

Cidofovir results in increased expression of GARS1 mRNA

NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876

G

1,4-alpha-glucan branching enzyme 1

increases expression

ISO

Cidofovir results in increased expression of GBE1 mRNA

NCBI chr11:22,181,194...22,446,640
Ensembl chr11:22,181,103...22,446,638

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

ISO

Cidofovir results in decreased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

Cidofovir results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

ISO

Cidofovir results in increased expression of GCNT3 mRNA

NCBI chr 8:79,570,081...79,577,389
Ensembl chr 8:79,566,753...79,581,595

G

growth differentiation factor 15

increases expression

ISO

Cidofovir results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

golgi integral membrane protein 4

decreases expression

ISO

Cidofovir results in decreased expression of GOLIM4 mRNA

NCBI chr 2:162,939,429...163,031,901
Ensembl chr 2:162,939,429...163,031,901

G

glutamic-oxaloacetic transaminase 1

increases expression

ISO

Cidofovir results in increased expression of GOT1 mRNA

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycoprotein A33

increases expression

ISO

Cidofovir results in increased expression of GPA33 mRNA

NCBI chr13:80,914,119...80,947,738
Ensembl chr13:80,912,430...80,948,903

G

glycerol-3-phosphate acyltransferase 3

increases expression

ISO

Cidofovir results in increased expression of GPAT3 mRNA

NCBI chr14:9,018,762...9,072,552

G

glycoprotein nmb

decreases expression

ISO

Cidofovir results in decreased expression of GPNMB mRNA

NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:79,341,021...79,380,240

G

G protein-coupled receptor 87

decreases expression

ISO

Cidofovir results in decreased expression of GPR87 mRNA

NCBI chr 2:145,589,630...145,608,094
Ensembl chr 2:145,589,569...145,604,442

G

glutathione-disulfide reductase

increases expression

ISO

Cidofovir results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

H1.2 linker histone, cluster member

increases expression

ISO

Cidofovir results in increased expression of H1-2 mRNA

NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,779,051...41,822,317

G

hepatitis A virus cellular receptor 1

multiple interactions
increases secretion

ISO

Probenecid inhibits the reaction [Cidofovir results in increased secretion of HAVCR1 protein]; Tenofovir inhibits the reaction [Cidofovir results in increased secretion of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

HECT and RLD domain containing E3 ubiquitin protein ligase 3

decreases expression

ISO

Cidofovir results in decreased expression of HERC3 mRNA

NCBI chr 4:89,282,374...89,372,656
Ensembl chr 4:89,282,445...89,372,652

G

hypoxia inducible factor 1 subunit alpha

affects activity

ISO

Cidofovir affects the activity of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

increases expression

ISO

Cidofovir results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 1B

decreases expression

ISO

Cidofovir results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

decreases expression

ISO

Cidofovir results in decreased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

HIV-1 Tat interactive protein 2

affects expression

ISO

Cidofovir affects the expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815

G

isoleucyl-tRNA synthetase 1

increases expression

ISO

Cidofovir results in increased expression of IARS1 mRNA

NCBI chr17:15,147,357...15,193,716
Ensembl chr17:15,147,357...15,193,652

G

iduronate 2-sulfatase

decreases expression

ISO

Cidofovir results in decreased expression of IDS mRNA

NCBI chr X:154,070,781...154,093,681
Ensembl chr X:154,070,781...154,091,444

G

insulin-like growth factor 2 receptor

affects expression

ISO

Cidofovir affects the expression of IGF2R mRNA

NCBI chr 1:50,526,878...50,615,265
Ensembl chr 1:50,526,878...50,615,265

G

interleukin 19

increases secretion

ISO

Cidofovir results in increased secretion of IL19 protein

NCBI chr13:44,949,989...44,958,714
Ensembl chr13:44,949,989...44,958,714

G

inka box actin regulator 2

increases expression

ISO

Cidofovir results in increased expression of INKA2 mRNA

NCBI chr 2:195,873,617...195,888,983
Ensembl chr 2:195,873,497...195,893,605

G

insulin induced gene 1

increases expression

ISO

Cidofovir results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

iron-sulfur cluster assembly enzyme

increases expression

ISO

Cidofovir results in increased expression of ISCU mRNA

NCBI chr12:48,512,852...48,518,696
Ensembl chr12:48,512,852...48,518,696

G

integrin alpha FG-GAP repeat containing 2

affects expression

ISO

Cidofovir affects the expression of ITFG2 mRNA

NCBI chr 4:163,371,125...163,384,676
Ensembl chr 4:163,338,702...163,384,367

G

integrin subunit beta 1

affects expression

ISO

Cidofovir affects the expression of ITGB1 mRNA

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

lysine acetyltransferase 6B

decreases expression

ISO

Cidofovir results in decreased expression of KAT6B mRNA

NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343

G

lysine demethylase 3A

decreases expression

ISO

Cidofovir results in decreased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

Kelch-like ECH-associated protein 1

increases expression

ISO

Cidofovir results in increased expression of KEAP1 mRNA

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

keratin 15

increases expression

ISO

Cidofovir results in increased expression of KRT15 mRNA

NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,567,202...85,571,142

G

keratin 19

increases expression

ISO

Cidofovir results in increased expression of KRT19 mRNA

NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952

G

laminin subunit alpha 3

affects expression

ISO

Cidofovir affects the expression of LAMA3 mRNA

NCBI chr18:3,797,898...4,033,021
Ensembl chr18:3,797,939...4,026,449

G

leucyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of LARS1 mRNA

NCBI chr18:34,452,567...34,507,030
Ensembl chr18:34,452,561...34,506,938

G

LIM and cysteine-rich domains 1

increases expression

ISO

Cidofovir results in increased expression of LMCD1 mRNA

NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875

G

LRAT domain containing 2

increases expression

ISO

Cidofovir results in increased expression of LRATD2 mRNA

NCBI chr 7:94,270,753...94,276,445
Ensembl chr 7:94,073,513...94,277,046

G

listerin E3 ubiquitin protein ligase 1

decreases expression

ISO

Cidofovir results in decreased expression of LTN1 mRNA

NCBI chr11:40,090,169...40,147,159
Ensembl chr11:40,090,169...40,147,303

G

mannosidase, alpha, class 1A, member 2

decreases expression

ISO

Cidofovir results in decreased expression of MAN1A2 mRNA

NCBI chr 2:190,636,134...190,784,975
Ensembl chr 2:190,615,094...190,784,975

G

microtubule-associated protein, RP/EB family, member 2

increases expression

ISO

Cidofovir results in increased expression of MAPRE2 mRNA

NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796

G

MDM2 proto-oncogene

affects expression

ISO

Cidofovir affects the expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

metallothionein 2

increases expression

ISO

Cidofovir results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metadherin

decreases expression

ISO

Cidofovir results in decreased expression of MTDH mRNA

NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:67,192,393...67,249,584

G

mitochondrial fission process 1

increases expression

ISO

Cidofovir results in increased expression of MTFP1 mRNA

NCBI chr14:83,192,013...83,195,853
Ensembl chr14:83,192,021...83,195,927

G

MAX interactor 1, dimerization protein

decreases expression

ISO

Cidofovir results in decreased expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036

G

nicotinamide phosphoribosyltransferase

increases expression

ISO

Cidofovir results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

asparaginyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of NARS1 mRNA

NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782

G

non-SMC condensin I complex, subunit D2

affects expression

ISO

Cidofovir affects the expression of NCAPD2 mRNA

NCBI chr 4:159,655,051...159,677,938
Ensembl chr 4:159,655,051...159,677,938

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

ISO

Cidofovir results in decreased expression of NEDD9 mRNA

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

NFE2 like bZIP transcription factor 2

affects activity
affects expression

ISO

Cidofovir affects the activity of NFE2L2 protein
Cidofovir affects the expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

ninein

decreases expression

ISO

Cidofovir results in decreased expression of NIN mRNA

NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:94,263,206...94,363,610

G

ninjurin 1

increases expression

ISO

Cidofovir results in increased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

NAD(P)H quinone dehydrogenase 1

decreases expression

ISO

Cidofovir results in decreased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

ISO

Cidofovir results in decreased expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

neuronal regeneration related protein

increases expression

ISO

Cidofovir results in increased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

nucleoside-triphosphatase, cancer-related

increases expression

ISO

Cidofovir results in increased expression of NTPCR mRNA

NCBI chr19:70,598,816...70,612,580
Ensembl chr19:70,593,274...70,613,197

G

oxidative stress induced growth inhibitor 1

affects expression

ISO

Cidofovir affects the expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

3-oxoacyl-ACP synthase, mitochondrial

increases expression

ISO

Cidofovir results in increased expression of OXSM mRNA

NCBI chr15:11,641,177...11,645,370
Ensembl chr15:11,634,473...11,683,429

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

ISO

Cidofovir results in decreased expression of P4HA1 mRNA

NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,845,141...27,895,404

G

pantothenate kinase 1

decreases expression

ISO

Cidofovir results in decreased expression of PANK1 mRNA

NCBI chr 1:241,737,371...241,808,126
Ensembl chr 1:241,741,083...241,807,824

G

phosphodiesterase 8A

decreases expression

ISO

Cidofovir results in decreased expression of PDE8A mRNA

NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215

G

protein disulfide isomerase family A, member 5

increases expression

ISO

Cidofovir results in increased expression of PDIA5 mRNA

NCBI chr11:78,777,436...78,892,370
Ensembl chr11:78,777,419...78,864,329

G

pyruvate dehydrogenase kinase 4

increases expression

ISO

Cidofovir results in increased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 1

increases expression

ISO

Cidofovir results in increased expression of PDLIM1 mRNA

NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:248,991,818...249,047,379

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

affects expression

ISO

Cidofovir affects the expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

phosphoglycerate dehydrogenase

affects expression

ISO

Cidofovir affects the expression of PHGDH mRNA

NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:188,595,700...188,624,789

G

pleckstrin homology-like domain, family A, member 3

increases expression

ISO

Cidofovir results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

p53-induced death domain protein 1

affects expression

ISO

Cidofovir affects the expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

pirin

increases expression

ISO

Cidofovir results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

plectin

decreases expression

ISO

Cidofovir results in decreased expression of PLEC mRNA

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

polo-like kinase 3

increases expression

ISO

Cidofovir results in increased expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

phorbol-12-myristate-13-acetate-induced protein 1

affects expression

ISO

Cidofovir affects the expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

prostate transmembrane protein, androgen induced 1

increases expression

ISO

Cidofovir results in increased expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

patatin-like phospholipase domain containing 6

increases expression

ISO

Cidofovir results in increased expression of PNPLA6 mRNA

NCBI chr12:6,372,284...6,401,632
Ensembl chr12:6,372,293...6,401,631

G

podocalyxin-like

decreases expression

ISO

Cidofovir results in decreased expression of PODXL mRNA

NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:61,102,419...61,149,789

G

RNA polymerase III subunit F

decreases expression

ISO

Cidofovir results in decreased expression of POLR3F mRNA

NCBI chr 3:152,361,798...152,378,169
Ensembl chr 3:152,361,798...152,378,168

G

peroxisome proliferator-activated receptor gamma

affects activity

ISO

Cidofovir affects the activity of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPFIA binding protein 1

increases expression

ISO

Cidofovir results in increased expression of PPFIBP1 mRNA

NCBI chr 4:181,538,249...181,682,079
Ensembl chr 4:181,539,450...181,682,076

G

peptidylprolyl isomerase G

decreases expression

ISO

Cidofovir results in decreased expression of PPIG mRNA

NCBI chr 3:74,891,846...74,923,010
Ensembl chr 3:74,891,846...74,920,750

G

protein phosphatase 1, regulatory subunit 15A

increases expression

ISO

Cidofovir results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 4, regulatory subunit 2

decreases expression

ISO

Cidofovir results in decreased expression of PPP4R2 mRNA

NCBI chr 4:135,010,919...135,051,844
Ensembl chr 4:135,010,919...135,051,844

G

protein regulator of cytokinesis 1

increases expression

ISO

Cidofovir results in increased expression of PRC1 mRNA

NCBI chr 1:143,659,312...143,681,019
Ensembl chr 1:143,659,481...143,681,012

G

PR/SET domain 1

decreases expression

ISO

Cidofovir results in decreased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

protein kinase AMP-activated non-catalytic subunit beta 2

decreases expression

ISO

Cidofovir results in decreased expression of PRKAB2 mRNA

NCBI chr 2:187,946,008...187,961,615
Ensembl chr 2:187,945,982...187,961,608

G

phosphoribosyl pyrophosphate synthetase 1

increases expression

ISO

Cidofovir results in increased expression of PRPS1 mRNA

NCBI chr X:108,920,663...108,942,713
Ensembl chr X:108,920,651...108,942,711

G

phosphoserine aminotransferase 1

increases expression

ISO

Cidofovir results in increased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

paraspeckle component 1

decreases expression

ISO

Cidofovir results in decreased expression of PSPC1 mRNA

NCBI chr15:34,941,445...35,027,460
Ensembl chr15:34,967,477...35,026,828

G

pyrroline-5-carboxylate reductase 1

increases expression

ISO

Cidofovir results in increased expression of PYCR1 mRNA

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

RAB26, member RAS oncogene family

increases expression

ISO

Cidofovir results in increased expression of RAB26 mRNA

NCBI chr10:14,057,942...14,062,602
Ensembl chr10:14,057,942...14,062,577

G

RAB31, member RAS oncogene family

increases expression

ISO

Cidofovir results in increased expression of RAB31 mRNA

NCBI chr 9:112,693,596...112,828,104
Ensembl chr 9:112,693,597...112,828,092

G

retinoic acid receptor, alpha

increases expression

ISO

Cidofovir results in increased expression of RARA mRNA

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

increases expression

ISO

Cidofovir results in increased expression of RFFL mRNA

NCBI chr10:68,238,273...68,301,225
Ensembl chr10:68,238,273...68,321,902

G

Ras-like without CAAX 1

increases expression

ISO

Cidofovir results in increased expression of RIT1 mRNA

NCBI chr 2:176,478,616...176,493,269
Ensembl chr 2:176,478,596...176,494,684

G

RLF zinc finger

decreases expression

ISO

Cidofovir results in decreased expression of RLF mRNA

NCBI chr 5:139,996,782...140,052,419
Ensembl chr 5:139,996,782...140,052,419

G

Rho family GTPase 1

increases expression

ISO

Cidofovir results in increased expression of RND1 mRNA

NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392

G

Rho family GTPase 3

affects expression

ISO

Cidofovir affects the expression of RND3 mRNA

NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:55,980,355...55,998,536

G

ring finger protein 121

decreases expression

ISO

Cidofovir results in decreased expression of RNF121 mRNA

NCBI chr 1:165,789,356...165,858,832
Ensembl chr 1:165,789,360...165,858,884

G

Ro60, Y RNA binding protein

decreases expression

ISO

Cidofovir results in decreased expression of RO60 mRNA

NCBI chr13:58,049,838...58,070,828
Ensembl chr13:58,049,858...58,076,264

G

ribosomal protein S27-like

increases expression

ISO

Cidofovir results in increased expression of RPS27L mRNA

NCBI chr 8:76,443,658...76,448,593
Ensembl chr12:33,713,661...33,714,130
Ensembl chr 8:33,713,661...33,714,130

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

decreases expression

ISO

Cidofovir results in decreased expression of RRM2B mRNA

NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670

G

ribosomal L1 domain containing 1

affects expression

ISO

Cidofovir affects the expression of RSL1D1 mRNA

NCBI chr10:4,931,839...4,943,726
Ensembl chr10:4,904,792...4,946,566

G

arginine and serine rich coiled-coil 2

decreases expression

ISO

Cidofovir results in decreased expression of RSRC2 mRNA

NCBI chr12:38,500,709...38,520,715
Ensembl chr12:38,500,770...38,520,707

G

RUNX family transcription factor 1

increases expression

ISO

Cidofovir results in increased expression of RUNX1 mRNA

NCBI chr11:45,325,778...45,560,300
Ensembl chr11:45,329,044...45,564,925

G

RUNX family transcription factor 2

increases expression

ISO

Cidofovir results in increased expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

seryl-tRNA synthetase 1

increases expression

ISO

Cidofovir results in increased expression of SARS1 mRNA

NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:198,753,675...198,769,365

G

stromal cell-derived factor 2-like 1

increases expression

ISO

Cidofovir results in increased expression of SDF2L1 mRNA

NCBI chr11:97,376,878...97,379,120
Ensembl chr11:97,376,878...97,379,120

G

serpin family B member 5

increases expression

ISO

Cidofovir results in increased expression of SERPINB5 mRNA

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400

G

SERTA domain containing 1

increases expression

ISO

Cidofovir results in increased expression of SERTAD1 mRNA

NCBI chr 1:91,903,297...91,906,565
Ensembl chr 1:91,891,814...91,907,001

G

sestrin 1

increases expression

ISO

Cidofovir results in increased expression of SESN1 mRNA

NCBI chr20:46,876,918...46,970,010
Ensembl chr20:46,876,895...46,970,010

G

senataxin

decreases expression

ISO

Cidofovir results in decreased expression of SETX mRNA

NCBI chr 3:32,825,771...32,878,740
Ensembl chr 3:32,828,412...32,878,740

G

stratifin

increases expression

ISO

Cidofovir results in increased expression of SFN mRNA

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

SH3 domain and tetratricopeptide repeats 1

decreases expression

ISO

Cidofovir results in decreased expression of SH3TC1 mRNA

NCBI chr14:79,230,322...79,274,622
Ensembl chr14:79,230,371...79,274,620

G

SH3 and multiple ankyrin repeat domains 3

affects expression

ISO

Cidofovir affects the expression of SHANK3 mRNA

NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:122,448,323...122,510,410

G

siah E3 ubiquitin protein ligase 2

affects expression

ISO

Cidofovir affects the expression of SIAH2 mRNA

NCBI chr 2:145,063,847...145,081,675
Ensembl chr 2:145,063,857...145,081,873

G

salt-inducible kinase 1

affects expression

ISO

Cidofovir affects the expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

signal-induced proliferation-associated 1 like 2

decreases expression

ISO

Cidofovir results in decreased expression of SIPA1L2 mRNA

NCBI chr19:70,287,134...70,437,810
Ensembl chr19:70,287,147...70,437,773

G

SIVA1, apoptosis-inducing factor

increases expression

ISO

Cidofovir results in increased expression of SIVA1 mRNA

NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790

G

solute carrier family 12, member 8

affects expression

ISO

Cidofovir affects the expression of SLC12A8 mRNA

NCBI chr11:80,622,000...80,771,674
Ensembl chr11:80,622,000...80,771,659

G

solute carrier family 1 member 4

increases expression

ISO

Cidofovir results in increased expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 1 member 5

increases expression

ISO

Cidofovir results in increased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 22 member 6

increases import
multiple interactions
increases response to substance

ISO

SLC22A6 protein results in increased import of Cidofovir
SLC22A6 protein results in increased uptake of and results in increased susceptibility to Cidofovir
SLC22A6 protein results in increased susceptibility to Cidofovir

PMID:23856525 PMID:25448811 PMID:29738843

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

increases response to substance

ISO

SLC22A8 protein results in increased susceptibility to Cidofovir

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 25 member 20

increases expression

ISO

Cidofovir results in increased expression of SLC25A20 mRNA

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 27 member 2

decreases expression

ISO

Cidofovir results in decreased expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 2 member 1

increases expression

ISO

Cidofovir results in increased expression of SLC2A1 mRNA

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 3 member 2

increases expression

ISO

Cidofovir results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 6 member 6

affects expression

ISO

Cidofovir affects the expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

solute carrier family 6 member 9

decreases expression

ISO

Cidofovir results in decreased expression of SLC6A9 mRNA

NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172

G

solute carrier family 7 member 1

increases expression

ISO

Cidofovir results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 7 member 5

increases expression

ISO

Cidofovir results in increased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:66,843,808...66,872,412

G

solute carrier organic anion transporter family, member 2b1

increases expression

ISO

Cidofovir results in increased expression of SLCO2B1 mRNA

NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279

G

small ArfGAP 1

decreases expression

ISO

Cidofovir results in decreased expression of SMAP1 mRNA

NCBI chr 9:33,746,489...33,838,488
Ensembl chr 9:33,746,489...33,838,734

G

SON DNA and RNA binding protein

decreases expression

ISO

Cidofovir results in decreased expression of SON mRNA

NCBI chr11:44,336,818...44,409,127
Ensembl chr11:44,377,976...44,409,127

G

sortilin related receptor 1

decreases expression

ISO

Cidofovir results in decreased expression of SORL1 mRNA

NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:51,238,722...51,401,446

G

sprouty RTK signaling antagonist 1

affects expression

ISO

Cidofovir affects the expression of SPRY1 mRNA

NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956

G

steroid 5 alpha-reductase 3

decreases expression

ISO

Cidofovir results in decreased expression of SRD5A3 mRNA

NCBI chr14:32,400,603...32,414,987
Ensembl chr14:32,400,603...32,415,117

G

sulfiredoxin 1

increases expression

ISO

Cidofovir results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

spermatid perinuclear RNA binding protein

decreases expression

ISO

Cidofovir results in decreased expression of STRBP mRNA

NCBI chr 3:41,738,096...41,879,054
Ensembl chr 3:41,712,311...41,824,707

G

sulfatase 2

decreases expression

ISO

Cidofovir results in decreased expression of SULF2 mRNA

NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651

G

transaldolase 1

increases expression

ISO

Cidofovir results in increased expression of TALDO1 mRNA

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

TAO kinase 1

decreases expression

ISO

Cidofovir results in decreased expression of TAOK1 mRNA

NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,871,198...62,957,595

G

threonyl-tRNA synthetase 1

decreases expression

ISO

Cidofovir results in decreased expression of TARS1 mRNA

NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802

G

thromboxane A synthase 1

increases expression

ISO

Cidofovir results in increased expression of TBXAS1 mRNA

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969

G

transcription factor AP-2 alpha

decreases expression

ISO

Cidofovir results in decreased expression of TFAP2A mRNA

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

TP53 induced glycolysis regulatory phosphatase

increases expression

ISO

Cidofovir results in increased expression of TIGAR mRNA

NCBI chr 4:161,613,306...161,632,248
Ensembl chr 4:161,613,306...161,632,229

G

translocase of inner mitochondrial membrane 17b

affects expression

ISO

Cidofovir affects the expression of TIMM17B mRNA

NCBI chr X:17,268,257...17,275,424
Ensembl chr X:17,268,257...17,275,563

G

tubulointerstitial nephritis antigen

decreases expression

ISO

Cidofovir results in decreased expression of TINAG mRNA

NCBI chr 8:86,680,441...86,765,485
Ensembl chr 8:86,680,442...86,765,485

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

ISO

Cidofovir results in increased expression of TIPARP mRNA

NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:152,063,751...152,090,406

G

transmembrane protein 45b

decreases expression

ISO

Cidofovir results in decreased expression of TMEM45B mRNA

NCBI chr 8:38,123,423...38,168,599
Ensembl chr 8:38,123,423...38,168,599

G

transmembrane protein 94

decreases expression

ISO

Cidofovir results in decreased expression of TMEM94 mRNA

NCBI chr10:101,490,496...101,525,983
Ensembl chr10:101,490,481...101,525,975

G

transmembrane O-mannosyltransferase targeting cadherins 2

decreases expression

ISO

Cidofovir results in decreased expression of TMTC2 mRNA

NCBI chr 7:42,280,746...42,695,651
Ensembl chr 7:42,280,746...42,693,350

G

TNF superfamily member 9

increases expression

ISO

Cidofovir results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339

G

DNA topoisomerase I

affects expression

ISO

Cidofovir affects the expression of TOP1 mRNA

NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327

G

tumor protein p53

increases expression
affects activity

ISO

Cidofovir results in increased expression of TP53 protein
Cidofovir affects the activity of TP53 protein

PMID:11697818 PMID:25596134

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 inducible protein 3

increases expression

ISO

Cidofovir results in increased expression of TP53I3 mRNA

NCBI chr 6:33,537,779...33,545,204

G

tumor protein p53 inducible nuclear protein 1

affects expression

ISO

Cidofovir affects the expression of TP53INP1 mRNA

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484

G

two pore segment channel 1

increases expression

ISO

Cidofovir results in increased expression of TPCN1 mRNA

NCBI chr12:41,633,399...41,690,200
Ensembl chr12:41,633,398...41,690,200

G

TPD52 like 1

affects expression

ISO

Cidofovir affects the expression of TPD52L1 mRNA

NCBI chr 1:27,991,114...28,109,767
Ensembl chr 1:27,991,131...28,110,158

G

TRAF type zinc finger domain containing 1

increases expression

ISO

Cidofovir results in increased expression of TRAFD1 mRNA

NCBI chr12:40,826,251...40,840,169
Ensembl chr12:40,825,851...40,841,320

G

TP53 regulated inhibitor of apoptosis 1

increases expression

ISO

Cidofovir results in increased expression of TRIAP1 mRNA

NCBI chr12:46,928,273...46,930,766
Ensembl chr12:46,928,273...46,930,766

G

tetraspanin 12

decreases expression

ISO

Cidofovir results in decreased expression of TSPAN12 mRNA

NCBI chr 4:51,279,562...51,355,030
Ensembl chr 4:51,279,563...51,355,030

G

thioredoxin 1

increases expression

ISO

Cidofovir results in increased expression of TXN mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin reductase 1

increases expression

ISO

Cidofovir results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

ubiquitin-conjugating enzyme E2G 2

increases expression

ISO

Cidofovir results in increased expression of UBE2G2 mRNA

NCBI chr20:10,983,322...11,005,060
Ensembl chr20:10,983,325...11,005,187

G

ubiquitin-conjugating enzyme E2O

affects expression

ISO

Cidofovir affects the expression of UBE2O mRNA

NCBI chr10:102,264,418...102,311,578
Ensembl chr10:102,264,418...102,311,549

G

unk like zinc finger

affects expression

ISO

Cidofovir affects the expression of UNKL mRNA

NCBI chr10:14,710,627...14,756,725
Ensembl chr10:14,710,563...14,756,724

G

ubiquitin specific peptidase 3

affects expression

ISO

Cidofovir affects the expression of USP3 mRNA

NCBI chr 8:75,973,278...76,049,151
Ensembl chr 8:75,974,615...76,049,153

G

vascular endothelial growth factor B

increases expression

ISO

Cidofovir results in increased expression of VEGFB mRNA

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152

G

vasoactive intestinal peptide receptor 1

increases expression

ISO

Cidofovir results in increased expression of VIPR1 mRNA

NCBI chr 8:130,181,219...130,217,098
Ensembl chr 8:130,187,731...130,217,096

G

V-set domain containing T cell activation inhibitor 1

increases expression

ISO

Cidofovir results in increased expression of VTCN1 mRNA

NCBI chr 2:190,942,224...191,010,280
Ensembl chr 2:190,942,224...191,010,280

G

tryptophanyl-tRNA synthetase 1

increases expression

ISO

Cidofovir results in increased expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WW and C2 domain containing 2

decreases expression

ISO

Cidofovir results in decreased expression of WWC2 mRNA

NCBI chr16:50,991,096...51,154,529
Ensembl chr16:50,991,096...51,154,526

G

X-box binding protein 1

affects activity
increases expression

ISO

Cidofovir affects the activity of XBP1 protein
Cidofovir results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

XPC complex subunit, DNA damage recognition and repair factor

increases expression

ISO

Cidofovir results in increased expression of XPC mRNA

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:125,550,833...125,578,305

G

tyrosyl-tRNA synthetase 1

affects expression

ISO

Cidofovir affects the expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377

G

YEATS domain containing 2

affects expression

ISO

Cidofovir affects the expression of YEATS2 mRNA

NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292

G

YTH N6-methyladenosine RNA binding protein C2

decreases expression

ISO

Cidofovir results in decreased expression of YTHDC2 mRNA

NCBI chr18:37,517,286...37,582,551
Ensembl chr18:37,517,248...37,582,550

G

zinc finger, matrin type 3

increases expression

ISO

Cidofovir results in increased expression of ZMAT3 mRNA

NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:117,034,517...117,065,294

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO

costunolide results in decreased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

catalase

increases activity

EXP

costunolide results in increased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

catenin beta 1

increases expression

ISO

costunolide results in increased expression of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

interleukin 10

multiple interactions

ISO

costunolide inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

insulin 1

multiple interactions

EXP

costunolide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

nitric oxide synthase 2

multiple interactions

ISO

costunolide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

proliferating cell nuclear antigen

multiple interactions

ISO

costunolide inhibits the reaction [Ethanol results in decreased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

costunolide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

tight junction protein 1

increases expression

ISO

costunolide results in increased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

multiple interactions

ISO

costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD274 molecule

affects binding

ISO

daclatasvir binds to CD274 protein

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

Delavirdine results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

ISO

Didanosine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

homeostatic iron regulator

multiple interactions

ISO

HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine]

NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,841,252...41,851,208

G

interleukin 24

decreases expression

ISO

Didanosine results in decreased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

mitochondrially encoded cytochrome c oxidase II

decreases expression
multiple interactions

ISO

Didanosine results in decreased expression of COX2 mRNA
tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

solute carrier family 29 member 3

affects transport

ISO

SLC29A3 protein affects the transport of Didanosine

NCBI chr20:29,191,086...29,228,299
Ensembl chr20:29,191,127...29,228,299

G

secretory leukocyte peptidase inhibitor

increases expression

ISO

Didanosine results in increased expression of SLPI mRNA

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

efavirenz inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
efavirenz results in decreased activity of ABCB11 protein

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

adiponectin, C1Q and collagen domain containing

decreases expression
decreases secretion

ISO

efavirenz results in decreased expression of ADIPOQ mRNA
efavirenz results in decreased secretion of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

albumin

affects binding

ISO

efavirenz binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

Bcl2-like 11

increases response to substance
increases expression

ISO

BCL2L11 protein results in increased susceptibility to efavirenz metabolite
efavirenz metabolite results in increased expression of BCL2L11 mRNA; efavirenz metabolite results in increased expression of BCL2L11 protein; efavirenz results in increased expression of BCL2L11 mRNA; efavirenz results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

calnexin

affects localization

ISO

efavirenz affects the localization of CANX protein

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

multiple interactions

ISO
EXP

efavirenz metabolite results in increased cleavage of and results in increased activity of CASP3 protein; efavirenz results in increased cleavage of and results in increased activity of CASP3 protein
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]

PMID:21958719 PMID:36309141

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

increases secretion

ISO

efavirenz results in increased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

efavirenz results in decreased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects metabolic processing
decreases activity
multiple interactions
increases metabolic processing

ISO

CYP2B6 gene polymorphism affects the metabolism of efavirenz; CYP2B6 protein affects the metabolism of efavirenz
efavirenz results in decreased activity of CYP2B6 protein
[efavirenz results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; [efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CYP2B6 protein results in increased metabolism of efavirenz

PMID:15622315 PMID:15769884 PMID:17041008 PMID:17559344 PMID:26599973

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

efavirenz results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases expression
increases activity

ISO

efavirenz results in decreased activity of CYP3A4 protein
efavirenz results in increased expression of CYP3A4 mRNA
efavirenz results in increased activity of CYP3A4 protein

PMID:15980690 PMID:16837568

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

increases expression

ISO

efavirenz results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dynamin 1-like

affects localization

ISO

efavirenz affects the localization of DNM1L protein modified form

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

ISO

efavirenz results in increased expression of EIF2AK3 protein modified form

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

fission, mitochondrial 1

increases expression

ISO

efavirenz results in increased expression of FIS1 mRNA

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

hepatocyte growth factor

increases secretion

ISO

efavirenz results in increased secretion of HGF protein

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

heat shock protein family A (Hsp70) member 9

multiple interactions

ISO

efavirenz promotes the reaction [VDAC1 protein binds to HSPA9 protein]

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398

G

interleukin 1 beta

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases secretion

ISO

efavirenz results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases phosphorylation

ISO

efavirenz metabolite results in increased phosphorylation of JUN protein; efavirenz results in increased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

leptin

decreases expression

ISO

efavirenz results in decreased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

lon peptidase 1, mitochondrial

multiple interactions
increases expression
increases response to substance

ISO

efavirenz results in increased expression of and affects the localization of LONP1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [efavirenz results in increased expression of LONP1 mRNA]
LONP1 protein results in increased susceptibility to efavirenz

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427

G

lipoprotein lipase

decreases expression

ISO

efavirenz results in decreased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

mitogen-activated protein kinase kinase kinase 5

increases phosphorylation

ISO

efavirenz metabolite results in increased phosphorylation of MAP3K5 protein; efavirenz results in increased phosphorylation of MAP3K5 protein

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [efavirenz metabolite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz results in increased phosphorylation of MAPK8 protein]
efavirenz metabolite results in increased phosphorylation of MAPK8 protein; efavirenz results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitofusin 2

increases expression

ISO

efavirenz results in increased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

myeloperoxidase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

nuclear receptor subfamily 1, group I, member 2

increases activity

EXP

efavirenz results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases activity

ISO
EXP

[efavirenz results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [efavirenz results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA

PMID:17041008 PMID:27732639

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

OPA1, mitochondrial dynamin like GTPase

increases expression

ISO

efavirenz results in increased expression of OPA1 mRNA

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

efavirenz results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

regulator of microtubule dynamics 3

increases expression

ISO

efavirenz results in increased expression of RMDN3 protein

NCBI chr 3:126,579,811...126,601,016
Ensembl chr 3:126,579,812...126,600,418

G

serpin family E member 1

increases secretion

ISO

efavirenz results in increased secretion of SERPINE1 protein

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

solute carrier family 5 member 5

multiple interactions

ISO

[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

sterol regulatory element binding transcription factor 1

decreases expression

ISO

efavirenz results in decreased expression of SREBF1 mRNA

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

thyroglobulin

increases expression

ISO

efavirenz results in increased expression of TG mRNA; efavirenz results in increased expression of TG protein

NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539

G

tumor necrosis factor

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thyroid peroxidase

increases expression

ISO

efavirenz results in increased expression of TPO mRNA; efavirenz results in increased expression of TPO protein

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

thyroid stimulating hormone subunit beta

multiple interactions

ISO

[efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [efavirenz co-treated with TSHB protein] results in increased expression of SLC5A5 protein; efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

thyroid stimulating hormone receptor

increases expression

ISO

efavirenz results in increased expression of TSHR mRNA

NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010

G

voltage-dependent anion channel 1

multiple interactions

ISO

efavirenz promotes the reaction [VDAC1 protein binds to HSPA9 protein]

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

ISO

Emtricitabine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

deoxycytidine kinase

multiple interactions
affects binding

ISO

DCK protein results in increased phosphorylation of and results in increased activity of Emtricitabine
Emtricitabine binds to DCK protein

NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,589,298...19,610,326

G

parkin RBR E3 ubiquitin protein ligase

decreases expression
multiple interactions

ISO

Emtricitabine results in decreased expression of PRKN protein
[Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

tumor protein p53

multiple interactions

ISO

[Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects activity

ISO

enfuvirtide affects the activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects activity

ISO

enfuvirtide affects the activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects activity

ISO

enfuvirtide affects the activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

EXP

favipiravir results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

EXP

favipiravir results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

increases expression

EXP

favipiravir results in increased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases activity

EXP

favipiravir results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

interleukin 6

increases expression

EXP

favipiravir results in increased expression of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mucin 1, cell surface associated

increases expression

EXP

favipiravir results in increased expression of MUC1 protein

NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491

G

nitric oxide synthase 2

increases expression

EXP

favipiravir results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

purinergic receptor P2X 7

increases expression

EXP

favipiravir results in increased expression of P2RX7 protein

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

DNA polymerase gamma, catalytic subunit

affects binding

ISO

favipiravir binds to POLG1 protein

NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:142,792,119...142,808,838

G

RELA proto-oncogene, NF-kB subunit

increases expression

EXP

favipiravir results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases response to substance
decreases response to substance

ISO

APEX1 protein mutant form results in increased susceptibility to Floxuridine
APEX1 protein results in decreased susceptibility to Floxuridine

PMID:19470598 PMID:22194930

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

ATR serine/threonine kinase

decreases response to substance

ISO

ATR protein results in decreased susceptibility to Floxuridine

PMID:21613406 PMID:22194930

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

complement C1q binding protein

decreases response to substance

ISO

C1QBP protein results in decreased susceptibility to Floxuridine

NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235

G

checkpoint kinase 1

multiple interactions

ISO

Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein

PMID:21613406 PMID:22194930

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions
increases activity

ISO

Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein
Floxuridine results in increased activity of CHEK2 protein

PMID:21613406 PMID:22194930

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

mutL homolog 1

multiple interactions
decreases response to substance

ISO

olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine]

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011

G

mutS homolog 2

multiple interactions
decreases response to substance

ISO

olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine]

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

methylenetetrahydrofolate reductase

affects response to substance

ISO

MTHFR protein affects the susceptibility to Floxuridine

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

poly (ADP-ribose) polymerase 1

decreases response to substance

ISO

PARP1 protein results in decreased susceptibility to Floxuridine

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

TIMP metallopeptidase inhibitor 3

affects response to substance
decreases response to substance

ISO

TIMP3 protein affects the susceptibility to Floxuridine
TIMP3 gene modified form results in decreased susceptibility to Floxuridine

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

thymidine kinase 1

increases expression

ISO

Floxuridine results in increased expression of TK1 protein

NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228

G

tumor protein p53

increases expression
affects activity

ISO

Floxuridine results in increased expression of TP53 protein
Floxuridine affects the activity of TP53 protein

PMID:19015155 PMID:35435491

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thymidylate synthetase

affects response to substance
increases response to substance
decreases response to substance

ISO

TYMS protein affects the susceptibility to Floxuridine
TYMS results in increased susceptibility to Floxuridine
TYMS protein results in decreased susceptibility to Floxuridine

PMID:2537495 PMID:10482907 PMID:15040806 PMID:17018589

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

uracil-DNA glycosylase

affects expression
increases response to substance
affects stability

ISO

Floxuridine affects the expression of UNG mRNA; Floxuridine affects the expression of UNG protein
UNG protein results in increased susceptibility to Floxuridine
Floxuridine affects the stability of UNG protein alternative form

NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257

G

X-ray repair cross complementing 1

decreases response to substance

ISO

XRCC1 protein results in decreased susceptibility to Floxuridine

PMID:21613406 PMID:22194930

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

G

X-ray repair cross complementing 4

decreases response to substance

ISO

XRCC4 results in decreased susceptibility to Floxuridine

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

decreases expression

ISO

Ganciclovir results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

MDM2 proto-oncogene

increases expression

ISO

Ganciclovir results in increased expression of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

tumor necrosis factor

increases secretion
multiple interactions

ISO

Ganciclovir results in increased secretion of TNF protein
Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression

ISO

Ganciclovir results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

ISO

Gemcitabine results in increased expression of A2M protein

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO

Gemcitabine results in decreased expression of ABCB1 mRNA; Gemcitabine results in decreased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acid phosphatase 3

decreases expression

ISO

Gemcitabine results in decreased expression of ACP3 protein

NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:113,785,032...113,833,033

G

ADAM metallopeptidase domain 17

multiple interactions

ISO

ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

adiponectin, C1Q and collagen domain containing

increases expression

ISO

Gemcitabine results in increased expression of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

alpha-fetoprotein

decreases expression

ISO

Gemcitabine results in decreased expression of AFP protein

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

1-acylglycerol-3-phosphate O-acyltransferase 2

decreases expression

ISO

Gemcitabine results in decreased expression of AGPAT2 mRNA

NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:29,814,924...29,826,581

G

AKT serine/threonine kinase 1

affects response to substance
decreases phosphorylation
multiple interactions

ISO

AKT1 protein affects the susceptibility to Gemcitabine
Gemcitabine results in decreased phosphorylation of AKT1 protein
[Gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with Gemcitabine] results in decreased phosphorylation of AKT1 protein; Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]

PMID:15867245 PMID:29782821 PMID:36400307

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions
decreases expression

ISO

sulforaphane promotes the reaction [Gemcitabine results in decreased expression of ALDH1A1 protein]

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 1 family, member A3

increases expression

ISO

Gemcitabine results in increased expression of ALDH1A3 mRNA

NCBI chr 1:129,392,516...129,436,552
Ensembl chr 1:129,392,516...129,427,777

G

aldehyde dehydrogenase 6 family, member A1

increases expression

ISO

Gemcitabine results in increased expression of ALDH6A1 mRNA

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

anaphase promoting complex subunit 1

increases expression

ISO

Gemcitabine results in increased expression of ANAPC1 mRNA

NCBI chr 3:136,303,350...136,383,464
Ensembl chr 3:136,303,413...136,383,464

G

ankyrin 3

increases expression

ISO

Gemcitabine results in increased expression of ANK3 mRNA

NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,601,826...19,084,879

G

ankyrin repeat domain 1

increases expression

ISO

Gemcitabine results in increased expression of ANKRD1 mRNA

NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:243,228,448...243,263,751

G

ANTXR cell adhesion molecule 1

affects expression

ISO

Gemcitabine affects the expression of ANTXR1 mRNA

NCBI chr 4:121,148,102...121,335,549
Ensembl chr 4:121,148,103...121,336,892

G

amyloid P component, serum

decreases expression

ISO

Gemcitabine results in decreased expression of APCS protein

NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824

G

apolipoprotein H

increases expression

ISO

Gemcitabine results in increased expression of APOH protein

NCBI chr10:93,841,992...93,855,897
Ensembl chr10:93,841,966...93,857,127

G

androgen receptor

multiple interactions

ISO

Gemcitabine binds to and results in decreased activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

amphiregulin

multiple interactions
decreases response to substance
increases cleavage
increases expression

ISO

ADAM17 protein promotes the reaction [Gemcitabine results in increased cleavage of AREG protein]
AREG protein results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of AREG protein

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641

G

ARF GTPase 1

decreases expression

ISO

Gemcitabine results in decreased expression of ARF1 mRNA

NCBI chr10:44,497,543...44,513,994

G

aryl hydrocarbon receptor nuclear translocator

increases expression

ISO

Gemcitabine results in increased expression of ARNT mRNA

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

activating transcription factor 3

increases expression

ISO

Gemcitabine results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

axin 2

affects expression

ISO

Gemcitabine affects the expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575

G

Axl receptor tyrosine kinase

multiple interactions

ISO

AXL protein promotes the reaction [Warfarin results in increased susceptibility to Gemcitabine]

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

[alvocidib co-treated with Gemcitabine] results in increased expression of BAX protein; [ICI 118551 co-treated with Gemcitabine] results in increased expression of BAX protein; [Mastic Resin co-treated with Gemcitabine] results in increased expression of BAX protein; [TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein; Gemcitabine promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]
Gemcitabine results in increased expression of BAX protein

PMID:15770523 PMID:17671697 PMID:20523344 PMID:21570961 PMID:36400307

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein
[alvocidib co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Aminophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [ICI 118551 co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Mastic Resin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Theophylline co-treated with Gemcitabine] results in decreased expression of BCL2 protein; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BCL2 protein]; Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; U 0126 inhibits the reaction [Gemcitabine results in decreased expression of BCL2 protein]

PMID:15476743 PMID:15645133 PMID:15770523 PMID:16929163 PMID:17440100 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions
decreases expression

ISO

Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil affects the expression of BCL2L1 protein]
Gemcitabine results in decreased expression of BCL2L1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein

PMID:15476743 PMID:16929163 PMID:17440100 PMID:38122923

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression

ISO

Gemcitabine results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

BCL6, transcription repressor

increases expression

ISO

Gemcitabine results in increased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

brain-derived neurotrophic factor

decreases expression

ISO

Gemcitabine results in decreased expression of BDNF protein

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

BH3 interacting domain death agonist

increases cleavage

ISO

Gemcitabine results in increased cleavage of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 2

increases expression

ISO

Gemcitabine results in increased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

multiple interactions
affects expression

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Gemcitabine affects the expression of BIRC3 mRNA

PMID:17039268 PMID:17440100

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein
Gemcitabine results in decreased expression of BIRC5 protein
Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 mRNA]; Gemcitabine inhibits the reaction [Fluorouracil results in decreased expression of BIRC5 protein]

PMID:16929163 PMID:17440100 PMID:38000456

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BCL2 interacting protein 3 like

increases expression

ISO

Gemcitabine results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

ISO

Gemcitabine results in decreased expression of BRAF mRNA

NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931

G

BRCA1, DNA repair associated

decreases response to substance
increases expression

ISO

BRCA1 results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of BRCA1 mRNA

PMID:20103597 PMID:21771338

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

caspase 3

increases cleavage
increases expression
increases activity
multiple interactions

ISO

Gemcitabine results in increased cleavage of CASP3 protein
Gemcitabine results in increased expression of CASP3 protein modified form
Gemcitabine results in increased activity of CASP3 protein
[10-propargyl-10-deazaaminopterin co-treated with Gemcitabine] results in increased activity of CASP3 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Gemcitabine] affects the activity of CASP3 protein; [3-(4-methylphenylsulfonyl)-2-propenenitrile co-treated with Gemcitabine] affects the activity of CASP3 protein; [alvocidib co-treated with Gemcitabine] results in increased cleavage of CASP3 protein; [Calcitriol co-treated with Gemcitabine] results in increased expression of CASP3 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP3 protein; [Vorinostat co-treated with Gemcitabine] results in increased activity of CASP3 protein; Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein; Gemcitabine results in increased expression of and results in increased activity of CASP3 protein; licoricidin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [Gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; PIF1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein]; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]

PMID:12479703 PMID:15476743 PMID:15726400 PMID:15770523 PMID:16153448 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 6

multiple interactions

ISO

[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP6 protein

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 8

increases cleavage
multiple interactions
increases activity

ISO

Gemcitabine results in increased cleavage of CASP8 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP8 protein; [Gemcitabine co-treated with TNFRSF10B] affects the activity of CASP8 protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein; Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]
Gemcitabine results in increased activity of CASP8 protein

PMID:12479703 PMID:14750167 PMID:17159604 PMID:17671697 PMID:18089714 More...

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases activity
increases cleavage

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein
Gemcitabine results in increased activity of CASP9 protein
Gemcitabine results in increased cleavage of CASP9 protein
[Calcitriol co-treated with Gemcitabine] results in increased expression of CASP9 protein; Quercetin promotes the reaction [Gemcitabine results in increased activity of CASP9 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]

PMID:12479703 PMID:15476743 PMID:15726400 PMID:17159604 PMID:17440100 More...

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 2

decreases expression

ISO

Gemcitabine results in decreased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

increases expression

ISO

Gemcitabine results in increased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

increases expression

ISO

Gemcitabine results in increased expression of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin B1

decreases expression
increases expression

ISO

Gemcitabine results in decreased expression of CCNB1 mRNA
Gemcitabine results in increased expression of CCNB1 protein

PMID:11504793 PMID:20103597

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Gemcitabine results in decreased expression of CCND1 mRNA; Gemcitabine results in decreased expression of CCND1 protein
Celecoxib promotes the reaction [Gemcitabine results in decreased expression of CCND1 protein]

PMID:16060994 PMID:17039268 PMID:17440100

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G2

increases expression

ISO

Gemcitabine results in increased expression of CCNG2 mRNA

NCBI chr14:15,088,694...15,097,190
Ensembl chr14:15,088,695...15,096,206

G

CD274 molecule

multiple interactions

ISO

[Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein]

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:236,496,463...236,549,951

G

CD40 molecule

decreases expression

ISO

Gemcitabine results in decreased expression of CD40 mRNA; Gemcitabine results in decreased expression of CD40 protein

PMID:17039268 PMID:20531411

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD40 ligand

decreases expression

ISO

Gemcitabine results in decreased expression of CD40LG protein

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:140,164,302...140,176,475

G

CD44 molecule

affects expression

ISO

Gemcitabine affects the expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

cytidine deaminase

affects response to substance
multiple interactions

ISO

CDA protein affects the susceptibility to Gemcitabine
[Crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to Gemcitabine; CDA protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]; CDA protein affects the susceptibility to [Gemcitabine co-treated with Oxaliplatin]

PMID:18728667 PMID:22973962

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:155,839,929...155,866,541

G

cell division cycle 25C

multiple interactions

ISO

[Gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cadherin 1

increases expression
multiple interactions

ISO

Gemcitabine results in increased expression of CDH1 mRNA; Gemcitabine results in increased expression of CDH1 protein
Gemcitabine promotes the reaction [Arsenic Trioxide results in increased expression of CDH1 protein]

PMID:17039268 PMID:36400307

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 2

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of CDH2 protein
Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased expression of CDH2 protein]

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

Gemcitabine results in increased expression of CDKN1A mRNA; Gemcitabine results in increased expression of CDKN1A protein
[alvocidib co-treated with Gemcitabine] results in increased expression of CDKN1A protein; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of CDKN1A protein; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]

PMID:15476743 PMID:15770523 PMID:16601104 PMID:17039268 PMID:25189999

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

decreases response to substance

ISO

CDKN1B results in decreased susceptibility to Gemcitabine

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein beta

increases expression

ISO

Gemcitabine results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

chordin-like 2

multiple interactions

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CHRDL2 protein

NCBI chr 1:163,755,316...163,782,758
Ensembl chr 1:163,755,316...163,782,757

G

creatine kinase B

decreases expression

ISO

Gemcitabine results in decreased expression of CKB mRNA

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

chloride intracellular channel 4

increases expression

ISO

Gemcitabine results in increased expression of CLIC4 mRNA

NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:152,737,371...152,797,118

G

clusterin

increases expression
affects response to substance

ISO

Gemcitabine results in increased expression of CLU protein
CLU protein affects the susceptibility to Gemcitabine

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

cannabinoid receptor 1

multiple interactions
increases expression

ISO

BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA]

NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252

G

cannabinoid receptor 2

multiple interactions
increases expression

ISO

BAY 11-7085 inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA]

NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of COL1A1 protein
Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

C-reactive protein

multiple interactions

ISO

[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of CRP protein]; Gemcitabine inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of CRP protein]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

colony stimulating factor 2

decreases expression

ISO

Gemcitabine results in decreased expression of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3

decreases expression

ISO

Gemcitabine results in decreased expression of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cysteine and glycine-rich protein 2

increases expression

ISO

Gemcitabine results in increased expression of CSRP2 mRNA

NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:48,235,383...48,266,238

G

collagen triple helix repeat containing 1

increases expression

ISO

Gemcitabine results in increased expression of CTHRC1 mRNA

NCBI chr 7:72,007,372...72,017,654
Ensembl chr 7:72,007,372...72,017,654

G

catenin beta 1

increases expression
decreases expression

ISO

Gemcitabine results in increased expression of CTNNB1 mRNA
Gemcitabine results in decreased expression of CTNNB1 protein

PMID:25605917 PMID:38000456

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine ligand 1

increases expression

ISO

Gemcitabine results in increased expression of CXCL1 mRNA

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 11

multiple interactions

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of CXCL11 protein

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567

G

C-X-C motif chemokine ligand 2

increases expression

ISO

Gemcitabine results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

increases expression

ISO

Gemcitabine results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 4

affects expression

ISO

Gemcitabine affects the expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome P450, family 24, subfamily a, polypeptide 1

decreases expression

ISO

Gemcitabine results in decreased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

DNA-damage-inducible transcript 4

affects expression

ISO

Gemcitabine affects the expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DExH-box helicase 9

decreases expression

ISO

Gemcitabine results in decreased expression of DHX9 mRNA

NCBI chr13:68,152,813...68,189,580
Ensembl chr13:68,152,813...68,189,546

G

discs large MAGUK scaffold protein 2

increases expression

ISO

Gemcitabine results in increased expression of DLG2 mRNA

NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:153,865,299...155,916,215

G

DNA methyltransferase 1

multiple interactions

ISO

[DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; DNMT1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 beta

multiple interactions

ISO

[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of DNMT3B protein

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

dihydropyrimidine dehydrogenase

multiple interactions

ISO

[TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine

NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778

G

dynein cytoplasmic 1 heavy chain 1

decreases expression

ISO

Gemcitabine results in decreased expression of DYNC1H1 mRNA

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116

G

endothelin 1

decreases expression

ISO

Gemcitabine results in decreased expression of EDN1 protein

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

endothelin 2

decreases expression

ISO

Gemcitabine results in decreased expression of EDN2 mRNA

NCBI chr 5:139,036,576...139,042,074
Ensembl chr 5:139,036,492...139,043,070

G

epidermal growth factor

multiple interactions
decreases expression

ISO

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]
Gemcitabine results in decreased expression of EGF protein

PMID:20531411 PMID:21613822

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
decreases expression
increases expression
increases phosphorylation
increases degradation

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; EGFR gene mutant form results in increased susceptibility to [Gemcitabine co-treated with Cisplatin co-treated with Erlotinib Hydrochloride]; Gefitinib inhibits the reaction [Gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]; Gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
Gemcitabine results in decreased expression of EGFR mRNA; Gemcitabine results in decreased expression of EGFR protein
Gemcitabine results in increased expression of EGFR mRNA
Gemcitabine results in increased phosphorylation of EGFR protein
Gemcitabine results in increased degradation of EGFR protein

PMID:17146438 PMID:20103597 PMID:20726858 PMID:21541241

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

increases expression

ISO

Gemcitabine results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

erb-b2 receptor tyrosine kinase 3

multiple interactions
increases phosphorylation

ISO

Gemcitabine promotes the reaction [HER3 protein binds to EGFR protein]
Gemcitabine results in increased phosphorylation of HER3 protein

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

estrogen receptor 1

multiple interactions

ISO

Gemcitabine binds to and results in decreased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

ETS variant transcription factor 1

increases expression

ISO

Gemcitabine results in increased expression of ETV1 mRNA

NCBI chr 6:61,316,836...61,408,985
Ensembl chr 6:61,317,429...61,408,959

G

ecotropic viral integration site 2B

decreases expression

ISO

Gemcitabine results in decreased expression of EVI2B mRNA

NCBI chr10:64,970,659...64,972,277
Ensembl chr10:64,964,719...64,979,417

G

coagulation factor VII

decreases expression

ISO

Gemcitabine results in decreased expression of F7 protein

NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738

G

Fas cell surface death receptor

increases expression

ISO

Gemcitabine results in increased expression of FAS mRNA; Gemcitabine results in increased expression of FAS protein

PMID:11138460 PMID:17159604

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box protein 25

increases expression

ISO

Gemcitabine results in increased expression of FBXO25 mRNA

NCBI chr16:82,370,123...82,404,002
Ensembl chr16:82,370,059...82,403,919

G

fibroblast growth factor 2

increases expression
multiple interactions

ISO

Gemcitabine results in increased expression of FGF2 protein
[Gemcitabine co-treated with IFNA2 protein] results in increased expression of FGF2 protein

PMID:12738744 PMID:20531411

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibrinogen gamma chain

affects expression

ISO

Gemcitabine affects the expression of FGG mRNA

NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170

G

FOS like 2, AP-1 transcription factor subunit

decreases expression

ISO

Gemcitabine results in decreased expression of FOSL2 mRNA

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

FXYD domain-containing ion transport regulator 3

increases expression

ISO

Gemcitabine results in increased expression of FXYD3 mRNA

NCBI chr 1:95,432,918...95,440,129
Ensembl chr 1:95,432,919...95,439,702

G

galactose-3-O-sulfotransferase 1

decreases expression

ISO

Gemcitabine results in decreased expression of GAL3ST1 mRNA

NCBI chr14:83,094,265...83,109,992
Ensembl chr14:83,094,385...83,109,978

G

growth arrest-specific 1

decreases expression

ISO

Gemcitabine results in decreased expression of GAS1 mRNA

NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657

G

golgi associated kinase 1B

decreases expression

ISO

Gemcitabine results in decreased expression of GASK1B mRNA

NCBI chr 2:167,345,738...167,410,606
Ensembl chr 2:167,345,809...167,410,603

G

growth differentiation factor 15

multiple interactions

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

GIPC PDZ domain containing family, member 1

affects response to substance

ISO

GIPC1 affects the susceptibility to Gemcitabine

NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725

G

GLI family zinc finger 2

affects expression

ISO

Gemcitabine affects the expression of GLI2 mRNA

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

glutaredoxin

increases expression

ISO

Gemcitabine results in increased expression of GLRX mRNA

NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543

G

golgi phosphoprotein 3

increases response to substance

ISO

GOLPH3 protein results in increased susceptibility to Gemcitabine

NCBI chr 2:63,072,610...63,103,091
Ensembl chr 2:63,074,256...63,113,577

G

glypican 3

increases expression

ISO

Gemcitabine results in increased expression of GPC3 mRNA

NCBI chr X:136,789,770...137,157,598
Ensembl chr X:136,789,770...137,157,639

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]; Gemcitabine inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glycogen synthase kinase 3 beta

increases phosphorylation

ISO

Gemcitabine results in increased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

general transcription factor 2A subunit 1

affects expression

ISO

Gemcitabine affects the expression of GTF2A1 mRNA

NCBI chr 6:116,219,614...116,252,220
Ensembl chr 6:116,219,614...116,252,220

G

H2A.X variant histone

increases expression
multiple interactions

ISO

Gemcitabine results in increased expression of H2AX protein; Gemcitabine results in increased expression of H2AX protein modified form
PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]; Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]]

PMID:20798217 PMID:37183367 PMID:38000456

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H4 clustered histone 14

decreases expression

ISO

Gemcitabine results in decreased expression of H4C2 mRNA

NCBI chr 2:186,520,468...186,520,863
Ensembl chr 4:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938
Ensembl chr17:171,403,627...171,403,938

G

histone deacetylase 9

increases expression

ISO

Gemcitabine results in increased expression of HDAC9 mRNA

NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:56,490,988...57,351,835

G

hypoxia inducible factor 1 subunit alpha

affects response to substance

ISO

HIF1A protein affects the susceptibility to Gemcitabine

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

ISO

Gemcitabine promotes the reaction [nuciferine results in decreased expression of HMGCR protein]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

multiple interactions
increases expression

ISO

CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]
Gemcitabine results in increased expression of HMOX1 mRNA; Gemcitabine results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

homeobox B2

increases expression

ISO

Gemcitabine results in increased expression of HOXB2 mRNA

NCBI chr10:81,814,340...81,816,731
Ensembl chr10:81,814,340...81,816,726

G

heat shock protein family A (Hsp70) member 1 like

decreases expression

ISO

Gemcitabine results in decreased expression of HSPA1L mRNA

NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Gemcitabine results in increased expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of ICAM1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein

PMID:17440100 PMID:20531411

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

decreases expression

ISO

Gemcitabine results in decreased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1 receptor

decreases expression

ISO

Gemcitabine results in decreased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor binding protein 3

affects expression

ISO

Gemcitabine affects the expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

interleukin 10

decreases expression

ISO

Gemcitabine results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 13

increases expression

ISO

Gemcitabine results in increased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 15

decreases expression

ISO

Gemcitabine results in decreased expression of IL15 protein

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 16

increases expression

ISO

Gemcitabine results in increased expression of IL16 protein

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 1 alpha

decreases expression

ISO

Gemcitabine results in decreased expression of IL1A protein

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of IL1B protein
[Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; [Oleanolic Acid co-treated with Gemcitabine] inhibits the reaction [IL1B protein results in increased expression of CD274 protein]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 mRNA]; Gemcitabine inhibits the reaction [IL1B protein results in increased expression of CD274 protein]

PMID:20531411 PMID:32894642

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

decreases expression

ISO

Gemcitabine results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

increases secretion
increases expression
decreases expression

ISO

Gemcitabine results in increased secretion of IL6 protein
Gemcitabine results in increased expression of IL6 mRNA
Gemcitabine results in decreased expression of IL6 protein

PMID:17039268 PMID:20531411 PMID:28007550

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin-linked kinase

affects response to substance

ISO

ILK protein affects the susceptibility to Gemcitabine

NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964

G

insulin 2

increases expression

ISO

Gemcitabine results in increased expression of INS protein

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

insulin induced gene 1

increases expression

ISO

Gemcitabine results in increased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

IQ motif containing GTPase activating protein 1

increases expression

ISO

Gemcitabine results in increased expression of IQGAP1 mRNA

NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:144,088,793...144,179,043

G

interleukin-1 receptor-associated kinase 2

increases expression

ISO

Gemcitabine results in increased expression of IRAK2 mRNA

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

interferon regulatory factor 3

decreases expression

ISO

Gemcitabine results in decreased expression of IRF3 mRNA

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

integrin subunit alpha V

multiple interactions

ISO

[ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

integrin subunit beta 6

multiple interactions

ISO

[ITGB6 co-treated with ITGAV] affects the susceptibility to Gemcitabine

NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333

G

intersectin 2

increases expression

ISO

Gemcitabine results in increased expression of ITSN2 mRNA

NCBI chr 6:33,336,086...33,446,818
Ensembl chr 6:33,336,441...33,446,818

G

junctional adhesion molecule 3

decreases expression

ISO

Gemcitabine results in decreased expression of JAM3 mRNA

NCBI chr 8:33,767,606...33,828,451
Ensembl chr 8:33,767,607...33,828,623

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium channel tetramerization domain containing 12

decreases expression

ISO

Gemcitabine results in decreased expression of KCTD12 mRNA

NCBI chr15:86,214,786...86,220,725
Ensembl chr15:86,214,840...86,224,539

G

KIT ligand

multiple interactions
decreases expression

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of KITLG protein
Gemcitabine results in decreased expression of KITLG protein

PMID:20531411 PMID:24979617

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

KLF transcription factor 8

increases expression

ISO

Gemcitabine results in increased expression of KLF8 mRNA

NCBI chr X:21,329,081...21,508,720

G

keratin 8

decreases expression

ISO

Gemcitabine results in decreased expression of KRT8 mRNA

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

La ribonucleoprotein 4B

increases expression

ISO

Gemcitabine results in increased expression of LARP4B mRNA

NCBI chr17:65,813,125...65,908,920
Ensembl chr17:65,830,022...65,908,676

G

leptin

decreases expression

ISO

Gemcitabine results in decreased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

LIF receptor subunit alpha

increases expression

ISO

Gemcitabine results in increased expression of LIFR mRNA

NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364

G

lysophosphatidic acid receptor 6

decreases expression

ISO

Gemcitabine results in decreased expression of LPAR6 mRNA

NCBI chr15:54,826,110...54,827,919
Ensembl chr15:54,823,717...54,978,783

G

leucine rich repeat containing 28

increases expression

ISO

Gemcitabine results in increased expression of LRRC28 mRNA

NCBI chr 1:130,526,757...130,655,991
Ensembl chr 1:130,537,930...130,655,949

G

lymphotoxin alpha

increases expression

ISO

Gemcitabine results in increased expression of LTA protein

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533

G

lysozyme 2

decreases expression

ISO

Gemcitabine results in decreased expression of LYZ mRNA

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

MAF bZIP transcription factor

increases expression

ISO

Gemcitabine results in increased expression of MAF mRNA

NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378

G

MAGE family member A10

decreases expression

ISO

Gemcitabine results in decreased expression of MAGEA10 mRNA

NCBI chr X:155,255,035...155,260,281
Ensembl chr X:155,255,035...155,260,281

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

increases expression

ISO

Gemcitabine results in increased expression of MAGI1 mRNA

NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833

G

mitogen activated protein kinase kinase 3

increases phosphorylation

ISO

Gemcitabine results in increased phosphorylation of MAP2K3 protein

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen-activated protein kinase kinase 6

increases phosphorylation

ISO

Gemcitabine results in increased phosphorylation of MAP2K6 protein

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

Gemcitabine results in increased phosphorylation of MAPK1 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein

PMID:15476743 PMID:23033007

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

ISO

Gemcitabine results in increased phosphorylation of MAPK3 protein
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein

PMID:15476743 PMID:23033007

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

myristoylated alanine rich protein kinase C substrate

increases expression
increases phosphorylation

ISO

Gemcitabine results in increased expression of MARCKS mRNA
Gemcitabine results in increased phosphorylation of MARCKS protein

PMID:9523737 PMID:17039268

NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882

G

methionyl-tRNA synthetase 1

increases expression

ISO

Gemcitabine results in increased expression of MARS1 mRNA

NCBI chr 7:65,006,456...65,023,880
Ensembl chr 7:64,998,544...65,023,753

G

MDM2 proto-oncogene

increases expression
decreases expression

ISO

Gemcitabine results in increased expression of MDM2 mRNA
Gemcitabine results in decreased expression of MDM2 mRNA

PMID:17039268 PMID:20103597

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

O-6-methylguanine-DNA methyltransferase

decreases expression

ISO

Gemcitabine results in decreased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microRNA 222

affects response to substance

ISO

MIR222 mRNA affects the susceptibility to Gemcitabine

NCBI chr X:6,022,621...6,022,723
Ensembl chr X:6,022,621...6,022,723

G

microRNA 24-2

multiple interactions

ISO

MIR24-2 mRNA affects the susceptibility to [Betulinic Acid co-treated with Gemcitabine]

NCBI chr19:40,859,455...40,859,562

G

marker of proliferation Ki-67

multiple interactions
decreases expression

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Gemcitabine results in decreased expression of MKI67 protein

PMID:17440100 PMID:38000456

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

matrix metallopeptidase 3

decreases expression

ISO

Gemcitabine results in decreased expression of MMP3 protein

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 9

multiple interactions

ISO

[Gemcitabine co-treated with IFNA2 protein] results in increased expression of MMP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein

PMID:12738744 PMID:17440100

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

increases expression

ISO

Gemcitabine results in increased expression of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mutS homolog 6

affects response to substance

ISO

MSH6 protein affects the susceptibility to Gemcitabine

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844

G

mesothelin

multiple interactions

EXP

Gemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form

NCBI chr10:15,276,489...15,285,921
Ensembl chr10:15,275,659...15,282,153

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases response to substance

ISO

Sodium Azide inhibits the reaction [COX3 protein results in decreased susceptibility to Gemcitabine]

NCBI chr MT:8,599...9,382
Ensembl chr MT:8,584...9,367

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

ISO

Gemcitabine results in decreased phosphorylation of MTOR protein
Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MAX interactor 1, dimerization protein

increases expression

ISO

Gemcitabine results in increased expression of MXI1 mRNA

NCBI chr 1:262,329,274...262,389,037
Ensembl chr 1:262,328,875...262,389,036

G

MYB proto-oncogene, transcription factor

increases expression

ISO

Gemcitabine results in increased expression of MYB mRNA

NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
affects response to substance

ISO

[Oligonucleotides binds to MYC gene] which results in increased susceptibility to Gemcitabine
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein
MYC affects the susceptibility to Gemcitabine

PMID:17440100 PMID:23681918

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

Nanog homeobox

decreases expression

ISO

Gemcitabine results in decreased expression of NANOG mRNA

PMID:25605917 PMID:35063459

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

nuclear cap binding protein subunit 1

increases expression

ISO

Gemcitabine results in increased expression of NCBP1 mRNA

NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:65,211,358...65,244,665

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

ISO

Gemcitabine results in increased expression of NEDD9 mRNA

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

neuraminidase 1

increases expression

ISO

Gemcitabine results in increased expression of NEU1 mRNA

NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,902,120...3,906,383

G

NFE2 like bZIP transcription factor 2

decreases response to substance
increases expression
multiple interactions

ISO

NFE2L2 protein results in decreased susceptibility to Gemcitabine
Gemcitabine results in increased expression of NFE2L2 mRNA; Gemcitabine results in increased expression of NFE2L2 protein
CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of CASC9 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]

PMID:21489257 PMID:35913601

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 2

affects expression

ISO

Gemcitabine affects the expression of NFKB2 mRNA

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions

ISO

[Mastic Resin co-treated with Gemcitabine] results in increased expression of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor epsilon

affects expression

ISO

Gemcitabine affects the expression of NFKBIE mRNA

NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872

G

nicotinamide N-methyltransferase

increases expression

ISO

Gemcitabine results in increased expression of NNMT mRNA

NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:57,825,464...57,843,174

G

notch receptor 1

multiple interactions
increases expression

ISO

sulforaphane inhibits the reaction [Gemcitabine results in increased expression of NOTCH1 protein]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

aminopeptidase puromycin sensitive

decreases expression

ISO

Gemcitabine results in decreased expression of NPEPPS mRNA

NCBI chr10:82,687,869...82,770,363
Ensembl chr10:82,687,871...82,770,363

G

nucleophosmin 1

decreases response to substance

ISO

NPM1 protein results in decreased susceptibility to Gemcitabine

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]; CASC9 protein affects the reaction [Gemcitabine results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Gemcitabine results in increased expression of NQO1 mRNA]
Gemcitabine results in increased expression of NQO1 mRNA; Gemcitabine results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 4, group A, member 3

increases expression

ISO

Gemcitabine results in increased expression of NR4A3 mRNA

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:67,157,375...67,198,285

G

neuregulin 1

increases expression

ISO

Gemcitabine results in increased expression of NRG1 mRNA

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849

G

neuropilin 1

decreases response to substance

ISO

NRP1 protein results in decreased susceptibility to Gemcitabine

NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702

G

nuclear protein 1, transcriptional regulator

decreases expression
affects response to substance

ISO

Gemcitabine results in decreased expression of NUPR1 mRNA
NUPR1 affects the susceptibility to Gemcitabine

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

olfactory receptor family 4 subfamily D member 6

affects response to substance

ISO

OR4D6 gene SNP affects the susceptibility to Gemcitabine

NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:218,463,801...218,464,745

G

oncostatin M

multiple interactions

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of OSM protein

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:83,327,554...83,331,827

G

pappalysin 1

decreases expression

ISO

Gemcitabine results in decreased expression of PAPPA protein

NCBI chr 5:83,513,358...83,751,364
Ensembl chr 5:83,513,358...83,751,361

G

progestin and adipoQ receptor family member 8

increases expression

ISO

Gemcitabine results in increased expression of PAQR8 mRNA

NCBI chr 9:30,808,921...30,858,599
Ensembl chr 9:30,808,923...30,861,043

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

Gemcitabine results in increased cleavage of PARP1 protein
[alvocidib co-treated with Gemcitabine] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein]

PMID:15770523 PMID:17146438 PMID:26894857 PMID:38122923

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

poly (ADP-ribose) polymerase 2

decreases response to substance

ISO

PARP2 protein results in decreased susceptibility to Gemcitabine

NCBI chr15:26,494,722...26,517,893
Ensembl chr15:26,494,731...26,517,891

G

proprotein convertase subtilisin/kexin type 9

increases expression

ISO

Gemcitabine results in increased expression of PCSK9 mRNA

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507

G

3-phosphoinositide dependent protein kinase-1

decreases response to substance

ISO

PDPK1 protein modified form results in decreased susceptibility to Gemcitabine

NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181

G

PDZK1 interacting protein 1

increases expression

ISO

Gemcitabine results in increased expression of PDZK1IP1 mRNA

NCBI chr 5:133,841,586...133,859,894
Ensembl chr 5:133,841,313...133,859,893

G

platelet and endothelial cell adhesion molecule 1

multiple interactions

ISO

Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

progesterone receptor

multiple interactions

ISO

Gemcitabine binds to and results in decreased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

PIF1 5'-to-3' DNA helicase

decreases response to substance
affects response to substance
multiple interactions

ISO

PIF1 protein results in decreased susceptibility to Gemcitabine
PIF1 protein affects the susceptibility to Gemcitabine
PIF1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP3 protein]; PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]; Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]]

NCBI chr 8:75,005,820...75,015,331
Ensembl chr 8:75,006,815...75,015,331

G

praja ring finger ubiquitin ligase 2

increases expression

ISO

Gemcitabine results in increased expression of PJA2 mRNA

NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703

G

pyruvate kinase M1/2

affects response to substance

ISO

PKM protein alternative form affects the susceptibility to Gemcitabine

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

plasminogen activator, urokinase

increases expression

ISO

Gemcitabine results in increased expression of PLAU mRNA

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

polo-like kinase 1

decreases expression
multiple interactions
affects response to substance

ISO

Gemcitabine results in decreased expression of PLK1; Gemcitabine results in decreased expression of PLK1 mRNA
[Gemcitabine results in decreased expression of PLK1] which results in increased susceptibility to Gemcitabine; ON 01910 promotes the reaction [PLK1 protein affects the susceptibility to Gemcitabine]

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

POU class 5 homeobox 1

decreases expression

ISO

Gemcitabine results in decreased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator activated receptor alpha

affects expression

ISO

Gemcitabine affects the expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

affects expression

ISO

Gemcitabine affects the expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

affects expression

ISO

Gemcitabine affects the expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PTPRF interacting protein alpha 4

increases expression

ISO

Gemcitabine results in increased expression of PPFIA4 mRNA

NCBI chr13:48,305,844...48,354,329
Ensembl chr13:48,305,848...48,354,279

G

protein phosphatase 1, regulatory subunit 15A

increases expression

ISO

Gemcitabine results in increased expression of PPP1R15A mRNA

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

phosphoserine aminotransferase 1

increases expression

ISO

Gemcitabine results in increased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

patched 1

affects expression

ISO

Gemcitabine affects the expression of PTCH1 mRNA

NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461

G

phosphatase and tensin homolog

affects expression

ISO

Gemcitabine affects the expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 1

decreases expression

ISO

Gemcitabine results in decreased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

[Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

decreases response to substance

ISO

PTK2 protein results in decreased susceptibility to Gemcitabine

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine phosphatase, non-receptor type 11

affects expression

ISO

Gemcitabine affects the expression of PTPN11 mRNA

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577

G

RAB8A, member RAS oncogene family

decreases expression

ISO

Gemcitabine results in decreased expression of RAB8A mRNA

NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,688,050...17,709,477

G

RNA binding motif protein 17

decreases response to substance

ISO

RBM17 protein results in decreased susceptibility to Gemcitabine

NCBI chr17:71,846,941...71,863,834
Ensembl chr17:71,846,916...71,864,431

G

regenerating family member 3 beta

decreases expression

ISO

Gemcitabine results in decreased expression of REG3A mRNA

NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:112,419,776...112,423,014

G

REL proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

ISO

sulforaphane promotes the reaction [Gemcitabine results in decreased expression of REL protein]

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
increases expression
multiple interactions

ISO

Gemcitabine results in increased phosphorylation of RELA protein
Gemcitabine results in increased expression of RELA protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein
[Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] affects the localization of RELA protein; [Gemcitabine co-treated with Doxorubicin co-treated with Paclitaxel] results in increased expression of RELA protein; licoricidin inhibits the reaction [Gemcitabine results in increased phosphorylation of RELA protein]; Mastic Resin inhibits the reaction [Gemcitabine results in increased expression of RELA protein]

PMID:17039268 PMID:17440100 PMID:20523344 PMID:29782821

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 2

increases expression

ISO

Gemcitabine results in increased expression of RGS2 mRNA

NCBI chr13:58,350,063...58,352,666
Ensembl chr13:58,349,163...58,352,697

G

ring finger protein 149

increases expression

ISO

Gemcitabine results in increased expression of RNF149 mRNA

NCBI chr 9:49,322,524...49,350,361
Ensembl chr 9:49,323,857...49,350,042

G

ribosomal protein L37

increases expression

ISO

Gemcitabine results in increased expression of RPL37 mRNA

NCBI chr 2:55,942,827...55,944,905
Ensembl chr 2:55,942,945...55,944,900

G

Ras-related GTP binding D

increases expression

ISO

Gemcitabine results in increased expression of RRAGD mRNA

NCBI chr 5:52,170,234...52,205,700
Ensembl chr 5:52,169,783...52,209,000

G

ribonucleotide reductase catalytic subunit M1

affects response to substance
multiple interactions

ISO

RRM1 protein affects the susceptibility to Gemcitabine
[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM1 protein

PMID:25189999 PMID:26894857

NCBI chr 1:166,235,904...166,260,206
Ensembl chr 1:166,235,900...166,260,944

G

ribonucleotide reductase regulatory subunit M2

multiple interactions
affects response to substance

ISO

[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of RRM2 protein
RRM2 protein affects the susceptibility to Gemcitabine

PMID:25189999 PMID:26894857

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370

G

ribosomal L24 domain containing 1

increases expression

ISO

Gemcitabine results in increased expression of RSL24D1 mRNA

NCBI chr 8:82,733,627...82,742,632
Ensembl chr 8:82,733,649...82,744,497

G

spermidine/spermine N1-acetyl transferase 1

increases expression

ISO

Gemcitabine results in increased expression of SAT1 mRNA

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

stearoyl-CoA desaturase

increases expression

ISO

Gemcitabine results in increased expression of SCD mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

stratifin

affects response to substance
multiple interactions
increases methylation
decreases response to substance

ISO

SFN protein affects the susceptibility to Gemcitabine
[DNMT1 protein binds to SFN promoter] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; [Gemcitabine results in decreased susceptibility to Gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased methylation of SFN gene; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN mRNA; [Gemcitabine results in decreased susceptibility to Gemcitabine] which results in increased expression of SFN protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; SFN protein inhibits the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; SFN protein inhibits the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; SFN protein promotes the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]
Gemcitabine results in increased methylation of SFN gene

PMID:25189999 PMID:26894857

NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:151,110,530...151,111,995

G

sonic hedgehog signaling molecule

decreases expression

ISO

Gemcitabine results in decreased expression of SHH mRNA

NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901

G

sirtuin 3

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of SIRT3 protein
[3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide co-treated with Gemcitabine] results in decreased expression of SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

solute carrier family 25 member 29

increases expression

ISO

Gemcitabine results in increased expression of SLC25A29 mRNA

NCBI chr 6:133,506,403...133,517,322
Ensembl chr 6:133,506,331...133,517,827

G

solute carrier family 28 member 1

multiple interactions

EXP
ISO

Gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]
Gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]

PMID:8713072 PMID:10772724

NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:144,490,623...144,531,544

G

solute carrier family 29 member 1

affects response to substance
increases uptake
multiple interactions
decreases response to substance
increases response to substance

ISO

SLC29A1 protein affects the susceptibility to Gemcitabine
SLC29A1 protein results in increased uptake of Gemcitabine
4-nitrobenzylthioinosine inhibits the reaction [SLC29A1 protein results in increased uptake of Gemcitabine]; [S 1 (combination) results in increased expression of SLC29A1 mRNA] which results in increased uptake of Gemcitabine; Fluorouracil promotes the reaction [SLC29A1 protein results in increased uptake of Gemcitabine]
SLC29A1 protein results in decreased susceptibility to Gemcitabine
SLC29A1 mRNA results in increased susceptibility to Gemcitabine; SLC29A1 protein results in increased susceptibility to Gemcitabine

PMID:15501974 PMID:16868479 PMID:17695509 PMID:18383843 PMID:18452103 More...

NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:22,902,471...22,914,620

G

solute carrier family 29 member 3

affects transport

ISO

SLC29A3 protein affects the transport of Gemcitabine

NCBI chr20:29,191,086...29,228,299
Ensembl chr20:29,191,127...29,228,299

G

solute carrier family 2 member 3

increases expression

ISO

Gemcitabine results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 43, member 3

decreases expression

ISO

Gemcitabine results in decreased expression of SLC43A3 mRNA

NCBI chr 3:90,414,822...90,450,654
Ensembl chr 3:90,415,977...90,436,976

G

SLIT and NTRK-like family, member 2

increases expression

ISO

Gemcitabine results in increased expression of SLITRK2 mRNA

NCBI chr X:150,287,418...150,299,832
Ensembl chr X:150,287,303...150,314,997

G

SMG1, nonsense mediated mRNA decay associated PI3K related kinase

decreases response to substance
multiple interactions

ISO

SMG1 protein results in decreased susceptibility to Gemcitabine
SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP3 protein]; SMG1 protein inhibits the reaction [Gemcitabine results in increased activity of CASP9 protein]

NCBI chr 1:181,876,134...181,977,894
Ensembl chr 1:181,876,134...181,977,894

G

smoothened, frizzled class receptor

increases expression

ISO

Gemcitabine results in increased expression of SMO mRNA

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of SNAI1 protein
Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased expression of SNAI1 protein]

NCBI chr 3:176,667,476...176,671,965

G

SRY-box transcription factor 2

increases expression

ISO

Gemcitabine results in increased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

secreted phosphoprotein 1

increases expression

ISO

Gemcitabine results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects response to substance
decreases response to substance
multiple interactions

ISO

SRC protein affects the susceptibility to Gemcitabine
SRC protein modified form results in decreased susceptibility to Gemcitabine; SRC protein results in decreased susceptibility to Gemcitabine
[AG 1879 co-treated with SRC] results in increased susceptibility to Gemcitabine

PMID:15073106 PMID:15194078

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

signal transducer and activator of transcription 3

decreases activity

ISO

Gemcitabine results in decreased activity of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

synaptotagmin binding, cytoplasmic RNA interacting protein

decreases expression

ISO

Gemcitabine results in decreased expression of SYNCRIP mRNA

NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386

G

SUZ RNA binding domain containing 1

decreases expression

ISO

Gemcitabine results in decreased expression of SZRD1 mRNA

NCBI chr 5:158,701,753...158,726,276
Ensembl chr 5:158,701,753...158,726,248

G

transcription elongation factor A like 9

increases expression

ISO

Gemcitabine results in increased expression of TCEAL9 mRNA

NCBI chr X:104,037,274...104,039,345
Ensembl chr X:104,032,421...104,041,562

G

treacle ribosome biogenesis factor 1

decreases expression

ISO

Gemcitabine results in decreased expression of TCOF1 mRNA

NCBI chr18:56,537,437...56,570,727
Ensembl chr18:56,537,437...56,570,727

G

telomerase reverse transcriptase

multiple interactions
decreases activity

ISO

[Fluorouracil co-treated with Gemcitabine] results in decreased activity of TERT protein
Gemcitabine results in decreased activity of TERT protein

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

transcription factor AP-2 alpha

increases response to substance
multiple interactions

ISO

TFAP2A protein results in increased susceptibility to Gemcitabine
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine

NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,229,910...24,253,219

G

transforming growth factor, beta 1

multiple interactions
decreases response to substance

ISO

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]; Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; U 0126 inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta 2

increases expression

ISO

Gemcitabine results in increased expression of TGFB2 mRNA

NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856

G

thrombopoietin

increases expression

ISO

Gemcitabine results in increased expression of THPO protein

Ensembl chr11:93,686,834...93,693,320

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

ISO

Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased expression of TIMP1 protein]
Gemcitabine results in decreased expression of TIMP1 protein

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

tumor necrosis factor

increases expression
affects expression

ISO

Gemcitabine results in increased expression of TNF protein
Gemcitabine affects the expression of TNF mRNA

PMID:17039268 PMID:20531411

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

Gemcitabine results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF receptor superfamily member 11B

increases expression

ISO

Gemcitabine results in increased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF superfamily member 10

multiple interactions

ISO

[TNFSF10 co-treated with Gemcitabine] affects the localization of BAX protein; [TNFSF10 co-treated with Gemcitabine] results in increased activity of CASP8 protein

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 8

multiple interactions

ISO

[Gemcitabine co-treated with Erlotinib Hydrochloride] affects the expression of TNFSF8 protein

NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858

G

tumor protein p53

increases expression
multiple interactions
affects activity

ISO

Gemcitabine results in increased expression of TP53 protein
[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of TRP53 protein]
[TFAP2A protein co-treated with TP53 gene mutant form] results in decreased susceptibility to Gemcitabine; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]
Gemcitabine affects the activity of TP53 protein

PMID:12082016 PMID:16601104 PMID:17671697 PMID:21489314 PMID:35435491 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein 1

increases expression

ISO

Gemcitabine results in increased expression of TP53BP1 mRNA

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747

G

tumor protein p53 inducible nuclear protein 1

increases expression

ISO

Gemcitabine results in increased expression of TP53INP1 mRNA

PMID:16570353 PMID:17039268

NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:29,051,264...29,069,484

G

TNF receptor-associated factor 1

affects expression

ISO

Gemcitabine affects the expression of TRAF1 mRNA

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264

G

tubulin, epsilon 1

increases expression

ISO

Gemcitabine results in increased expression of TUBE1 mRNA

NCBI chr20:44,105,405...44,124,947
Ensembl chr20:44,107,022...44,125,271

G

twist family bHLH transcription factor 1

decreases expression
multiple interactions

ISO

Gemcitabine results in decreased expression of TWIST1 protein
Gemcitabine promotes the reaction [Arsenic Trioxide results in decreased expression of TWIST1 protein]

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:56,398,061...56,404,965

G

thymidine phosphorylase

affects response to substance
multiple interactions

ISO

TYMP protein affects the susceptibility to Gemcitabine
[TYMP protein co-treated with DPYD protein] affects the susceptibility to Gemcitabine; TYMP protein affects the susceptibility to [Gemcitabine co-treated with Mitomycin]

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003

G

tyrosinase-related protein 1

affects expression

ISO

Gemcitabine affects the expression of TYRP1 mRNA

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquitin-conjugating enzyme E2C

decreases expression

ISO

Gemcitabine results in decreased expression of UBE2C mRNA

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

UDP-glucose glycoprotein glucosyltransferase 2

increases expression

ISO

Gemcitabine results in increased expression of UGGT2 mRNA

NCBI chr15:102,480,239...102,646,291
Ensembl chr15:102,480,781...102,646,410

G

ubiquitin-like with PHD and ring finger domains 1

multiple interactions

ISO

[Gemcitabine results in decreased susceptibility to Gemcitabine] which results in decreased expression of UHRF1 protein; [UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]; UHRF1 protein inhibits the reaction [Gemcitabine results in decreased susceptibility to Gemcitabine]

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792

G

vascular cell adhesion molecule 1

decreases expression

ISO

Gemcitabine results in decreased expression of VCAM1 protein

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

increases expression
multiple interactions

ISO

Gemcitabine results in increased expression of VEGFA mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein

PMID:17039268 PMID:17440100

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

VGF nerve growth factor inducible

decreases expression

ISO

Gemcitabine results in decreased expression of VGF mRNA

NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703

G

very low density lipoprotein receptor

increases expression

ISO

Gemcitabine results in increased expression of VLDLR mRNA

NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154

G

vacuole membrane protein 1

increases expression

ISO

Gemcitabine results in increased expression of VMP1

NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319

G

von Willebrand factor

decreases expression

ISO

Gemcitabine results in decreased expression of VWF protein

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

G

Wnt family member 5A

decreases expression

ISO

Gemcitabine results in decreased expression of WNT5A mRNA

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860

G

X-box binding protein 1

multiple interactions

ISO

Gemcitabine promotes the reaction [1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [arachidonylcyclopropylamide results in increased expression of XBP1 mRNA]; Gemcitabine promotes the reaction [Rimonabant results in increased expression of XBP1 mRNA]

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

X-linked inhibitor of apoptosis

affects response to substance

ISO

XIAP affects the susceptibility to Gemcitabine

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

Yes1 associated transcriptional regulator

multiple interactions
affects response to substance

ISO

Gemcitabine promotes the reaction [nuciferine results in decreased expression of and results in increased phosphorylation of YAP1 protein]; SFN protein affects the reaction [YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]]; YAP1 protein affects the reaction [Gemcitabine results in increased activity of and results in increased cleavage of CASP8 protein]; YAP1 protein affects the reaction [Gemcitabine results in increased cleavage of PARP1 protein]; YAP1 protein promotes the reaction [SFN protein results in decreased susceptibility to Gemcitabine]
YAP1 protein affects the susceptibility to Gemcitabine

PMID:26894857 PMID:31627466

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:13,380,551...13,451,437

G

zinc finger protein 110

increases expression

ISO

Gemcitabine results in increased expression of ZNF274 mRNA

NCBI chr 1:82,509,563...82,533,294
Ensembl chr 1:82,517,769...82,533,292

G

zinc finger protein 449

increases expression

ISO

Gemcitabine results in increased expression of ZNF449 mRNA

NCBI chr X:139,127,425...139,147,490
Ensembl chr X:139,127,479...139,147,489

G

zinc finger protein 521

decreases expression

ISO

Gemcitabine results in decreased expression of ZNF521 mRNA

NCBI chr18:5,050,297...5,343,188
Ensembl chr18:5,056,236...5,343,054

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA dehydrogenase, short/branched chain

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA

NCBI chr 1:195,619,088...195,660,564
Ensembl chr 1:195,619,038...195,660,561

G

acyl-CoA synthetase long-chain family member 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA

NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,940,747...39,002,873

G

actin alpha 2, smooth muscle

decreases expression

ISO

Lamivudine results in decreased expression of ACTA2 protein

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

AE binding protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA

NCBI chr14:84,951,577...84,962,840
Ensembl chr14:84,952,822...84,962,843

G

actin filament associated protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA

NCBI chr14:78,967,961...79,081,032
Ensembl chr14:78,967,961...79,080,939

G

albumin

affects binding

ISO

Lamivudine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

aquaporin 9

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

cAMP regulated phosphoprotein 21

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA

NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:120,912,970...121,031,357

G

acid sensing ion channel subunit 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA

NCBI chr10:66,368,308...67,438,237
Ensembl chr10:66,368,310...66,636,245

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

argininosuccinate synthase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA

NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:35,144,999...35,194,627

G

activating transcription factor 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATP synthase F1 subunit gamma

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5F1C mRNA

NCBI chr17:73,333,584...73,355,872
Ensembl chr17:73,333,588...73,383,073

G

ATP synthase membrane subunit c locus 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5MC3 mRNA

NCBI chr 3:79,218,014...79,220,664
Ensembl chr 3:79,218,014...79,220,664

G

ATP synthase membrane subunit f

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5MF mRNA

NCBI chr12:14,535,435...14,542,007
Ensembl chr12:14,522,832...14,542,709

G

ATP synthase peripheral stalk subunit d

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PD mRNA

NCBI chr10:101,156,673...101,161,926
Ensembl chr10:101,156,673...101,162,954

G

ATP synthase peripheral stalk subunit F6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PF mRNA

NCBI chr11:37,368,045...37,375,721
Ensembl chr11:37,368,042...37,375,466

G

ATP synthase peripheral stalk subunit OSCP

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5PO mRNA

NCBI chr11:44,651,171...44,657,483
Ensembl chr11:44,651,173...44,657,520

G

BCL2, apoptosis regulator

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2 interacting protein 3 like

increases expression

ISO

Lamivudine results in increased expression of BNIP3L protein

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

complement C1r

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA

NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714

G

complement C3a receptor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA

NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323

G

cysteinyl-tRNA synthetase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA

NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:208,182,788...208,225,407

G

caspase 3

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin A2

multiple interactions
decreases expression

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA
Lamivudine results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA

NCBI chr 5:40,063,589...40,081,731
Ensembl chr 5:40,063,623...40,093,370

G

cyclin D1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

decreases expression
multiple interactions

ISO

Lamivudine results in decreased expression of CCND2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E2

multiple interactions
decreases expression

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA
Lamivudine results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

CD36 molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

CD44 molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

CD83 molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047

G

cyclin-dependent kinase 7

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase inhibitor 1A

decreases expression
multiple interactions

ISO

Lamivudine results in decreased expression of CDKN1A mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 1C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA

NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:208,084,787...208,087,498

G

cyclin-dependent kinase inhibitor 2C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA

NCBI chr 5:129,639,736...129,645,564
Ensembl chr 5:129,639,736...129,644,891

G

complement factor D

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

cell death-inducing DFFA-like effector c

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

chloride voltage-gated channel 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA

NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984

G

collagen type III alpha 1 chain

decreases expression

ISO

Lamivudine results in decreased expression of COL3A1 protein

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

catechol-O-methyltransferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

cytochrome c oxidase subunit 5A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA

NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:66,818,196...66,830,279

G

cytochrome c oxidase subunit 5B

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA

NCBI chr 9:46,417,735...46,419,664
Ensembl chr 9:46,417,838...46,420,403

G

cytochrome c oxidase subunit 6A1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA

NCBI chr12:46,922,709...46,925,762
Ensembl chr12:46,912,648...46,925,768

G

cytochrome c oxidase subunit 6C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166

G

cytochrome c oxidase subunit 7C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA

NCBI chr 2:18,577,145...18,579,170
Ensembl chr 2:18,577,149...18,579,170

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine O-acetyltransferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA

NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099

G

cullin 7

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA

NCBI chr 9:21,816,703...21,830,344
Ensembl chr 9:21,816,703...21,830,344

G

cytochrome b5 type A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

deoxycytidine kinase

multiple interactions

ISO

DCK protein results in increased phosphorylation of and results in increased activity of Lamivudine

NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,589,298...19,610,326

G

decorin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

ISO

Lamivudine results in increased expression of DDIT3 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dihydrofolate reductase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA

NCBI chr 2:25,320,895...25,346,004

G

diablo, IAP-binding mitochondrial protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265

G

dihydrolipoamide S-succinyltransferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA

NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:110,489,392...110,514,357

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:11,361,168...11,386,599

G

dual specificity phosphatase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA

NCBI chr10:87,420,213...87,434,202
Ensembl chr10:87,419,494...87,434,063

G

enoyl-CoA hydratase, short chain 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA

NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:204,324,682...204,333,506

G

enoyl-CoA delta isomerase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA

NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,961,218...13,974,773

G

endothelin 1

multiple interactions
increases secretion

ISO

coenzyme Q10 inhibits the reaction [Lamivudine results in increased secretion of EDN1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

ELOVL fatty acid elongase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA

NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559

G

estrogen receptor 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

ETS variant transcription factor 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802

G

fatty acid desaturase 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

Fas apoptotic inhibitory molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

fatty acid synthase

multiple interactions

ISO

[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

ferredoxin reductase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA

NCBI chr10:101,006,845...101,015,582
Ensembl chr10:101,006,849...101,015,542

G

fumarate hydratase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

G0/G1switch 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucosidase, alpha; neutral C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA

NCBI chr 3:127,807,132...127,858,995
Ensembl chr 3:127,807,441...127,859,859

G

glycyl-tRNA synthetase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA

NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876

G

growth arrest-specific 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA

NCBI chr17:4,487,716...4,490,701
Ensembl chr17:4,484,283...4,497,657

G

grainyhead-like transcription factor 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA

NCBI chr 7:70,280,360...70,415,277
Ensembl chr 7:70,285,310...70,415,274

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

glycophorin A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene

NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291

G

H4 clustered histone 8

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA

NCBI chr17:47,176,246...47,180,690
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr 4:41,797,152...41,806,539

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:31,907,291...31,947,698

G

HCLS1 associated protein X-1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA

NCBI chr 2:177,731,918...177,735,670
Ensembl chr 2:177,731,921...177,735,390

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA

NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

harakiri, BCL2 interacting protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA

NCBI chr 2:188,858,574...188,864,694

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B3 mRNA

NCBI chr 2:188,826,756...188,832,734
Ensembl chr 2:188,826,110...188,904,981

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA

NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:63,867,820...63,887,223

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA

NCBI chr X:156,666,573...156,675,482
Ensembl chr X:156,666,577...156,675,799

G

interferon gamma

increases expression

ISO

Lamivudine results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

IKAROS family zinc finger 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA

NCBI chr 7:1,643,379...1,687,524
Ensembl chr 7:1,644,799...1,687,094

G

interleukin 1 beta

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 27 receptor subunit alpha

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA

NCBI chr19:41,014,730...41,026,740
Ensembl chr19:41,014,730...41,026,760

G

inositol polyphosphate-5-phosphatase E

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of INPP5E mRNA

NCBI chr 3:29,614,868...29,627,542
Ensembl chr 3:29,614,868...29,627,542

G

potassium voltage-gated channel modifier subfamily G member 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA

NCBI chr 3:177,379,593...177,412,986
Ensembl chr 3:177,392,031...177,411,507

G

kinesin family member C2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNA

NCBI chr 7:110,261,257...110,269,007
Ensembl chr 7:110,261,009...110,269,005

G

KLF transcription factor 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kelch-like family member 28

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA

NCBI chr 6:88,723,624...88,755,072
Ensembl chr 6:88,727,205...88,752,457

G

keratin 7

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of KRT7 mRNA

NCBI chr 7:134,407,626...134,423,787
Ensembl chr 7:134,407,584...134,423,786

G

kynureninase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

laminin subunit beta 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of LAMB3 mRNA

NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081

G

laminin subunit gamma 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102

G

lymphoid enhancer binding factor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

leptin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

lipoprotein lipase

decreases expression
multiple interactions

ISO

Lamivudine results in decreased expression of LPL mRNA
[Stavudine co-treated with Lamivudine co-treated with Indinavir] affects the expression of LPL mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of LPL mRNA; [Stavudine co-treated with Lamivudine] affects the expression of LPL mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

methionyl-tRNA synthetase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of MARS1 mRNA

NCBI chr 7:65,006,456...65,023,880
Ensembl chr 7:64,998,544...65,023,753

G

malic enzyme 1

multiple interactions
increases expression

ISO

[Stavudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine co-treated with Nelfinavir] results in decreased expression of ME1 mRNA; [Stavudine co-treated with Lamivudine] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA
Lamivudine results in increased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

mitofusin 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

mitofusin 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

MGAT4 family, member C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MGAT4C mRNA

NCBI chr 7:38,596,117...39,361,103
Ensembl chr 7:38,596,065...39,362,078

G

matrix metallopeptidase 1

increases expression

ISO

Lamivudine results in increased expression of MMP1 protein

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

myeloperoxidase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

melanocortin 2 receptor accessory protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA

NCBI chr11:43,477,382...43,489,118
Ensembl chr11:43,478,001...43,489,118

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA

PMID:17526437 PMID:18313992

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of COX3 mRNA

PMID:17526437 PMID:18313992

NCBI chr MT:8,599...9,382
Ensembl chr MT:8,584...9,367

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA

NCBI chr MT:3,904...4,942
Ensembl chr MT:3,892...4,929

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA

PMID:17526437 PMID:18313992

NCBI chr MT:11,736...13,565
Ensembl chr MT:11,721...13,553

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of MTHFD2 mRNA

NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350

G

myogenic differentiation 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

nucleosome assembly protein 1-like 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNA

NCBI chr 4:89,352,834...89,354,704
Ensembl chr 4:89,351,926...89,361,736

G

Ndufa4, mitochondrial complex associated

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNA

NCBI chr 4:40,968,391...40,975,559
Ensembl chr 4:40,968,391...40,975,559

G

NADH:ubiquinone oxidoreductase subunit AB1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAB1 mRNA

NCBI chr 1:186,075,933...186,091,843
Ensembl chr 1:186,057,113...186,089,373

G

NADH:ubiquinone oxidoreductase complex assembly factor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAF1 mRNA

NCBI chr 3:127,089,893...127,104,357
Ensembl chr 3:127,093,659...127,104,020

G

NADH:ubiquinone oxidoreductase subunit B3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB3 mRNA

NCBI chr 9:67,623,417...67,633,629
Ensembl chr 9:67,623,614...67,633,613

G

NADH:ubiquinone oxidoreductase subunit B5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB5 mRNA

NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:117,447,035...117,461,590

G

NADH:ubiquinone oxidoreductase subunit B9

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFB9 mRNA

NCBI chr 7:92,370,423...92,376,841
Ensembl chr 7:92,370,467...92,379,955

G

NADH:ubiquinone oxidoreductase subunit C1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFC1 mRNA

NCBI chr 2:137,597,944...137,601,819
Ensembl chr 2:137,600,156...137,601,735

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFS1 mRNA

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

niban apoptosis regulator 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NIBAN1 mRNA

NCBI chr13:66,224,219...66,377,728
Ensembl chr13:66,224,021...66,377,724

G

nocturnin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

nitric oxide synthase 3

multiple interactions
decreases phosphorylation

ISO

coenzyme Q10 inhibits the reaction [Lamivudine results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

natriuretic peptide A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

nucleoporin 210

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNA

NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:125,068,736...125,167,047

G

nucleoredoxin-like 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of NXNL2 mRNA

NCBI chr17:14,182,849...14,187,595
Ensembl chr17:14,182,849...14,188,208

G

ornithine decarboxylase antizyme 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA

NCBI chr 2:184,762,242...184,765,176
Ensembl chr 2:184,762,245...184,771,428

G

O-linked N-acetylglucosamine (GlcNAc) transferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of OGT mRNA

NCBI chr X:70,811,317...70,856,123
Ensembl chr X:70,811,319...70,856,123

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

G

opioid related nociceptin receptor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA

NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426

G

protocadherin related 15

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA

NCBI chr20:13,996,383...15,495,206
Ensembl chr20:13,999,116...15,493,958

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

post-GPI attachment to proteins 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of PGAP6 mRNA

NCBI chr10:15,643,081...15,652,912
Ensembl chr10:15,643,106...15,652,912

G

PHD finger protein 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of PHF6 mRNA

NCBI chr X:137,576,214...137,619,297
Ensembl chr X:137,576,235...137,615,914

G

p53-induced death domain protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

piwi-like RNA-mediated gene silencing 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PIWIL2 mRNA

NCBI chr15:51,841,104...51,907,729
Ensembl chr15:51,841,405...51,907,819

G

porcupine O-acyltransferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA

NCBI chr X:16,957,811...16,970,440
Ensembl chr X:16,957,810...16,970,439

G

POU class 5 homeobox 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

PR/SET domain 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

phosphoserine aminotransferase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNA

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

Rab9 effector protein with kelch motifs

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of RABEPK mRNA

NCBI chr 3:38,460,205...38,481,077
Ensembl chr 3:38,460,206...38,480,688

G

RB transcriptional corepressor like 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RB transcriptional corepressor like 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411

G

receptor accessory protein 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNA

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740

G

receptor-interacting serine-threonine kinase 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

ring finger protein 151

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of RNF151 mRNA

NCBI chr10:14,247,215...14,251,738
Ensembl chr10:14,247,215...14,251,204

G

RPA interacting protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of RPAIN mRNA

NCBI chr10:56,190,975...56,198,490
Ensembl chr10:56,190,967...56,199,685

G

S100 calcium binding protein A8

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA

NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:158,547,689...158,569,667

G

serine incorporator 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of SERINC1 mRNA

NCBI chr20:37,396,497...37,415,433
Ensembl chr20:37,396,497...37,443,124

G

sideroflexin 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

sideroflexin 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN2 mRNA

NCBI chr 1:255,388,428...255,400,724
Ensembl chr 1:255,388,429...255,409,780

G

sideroflexin 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN4 mRNA

NCBI chr 1:269,962,527...269,984,849
Ensembl chr 1:269,962,535...269,984,836

G

sphingosine-1-phosphate phosphatase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA

NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:100,161,024...100,182,259

G

solute carrier family 1 member 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A4 mRNA

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 1 member 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:86,584,949...86,599,054

G

solute carrier family 22 member 1

increases uptake

ISO

SLC22A1 protein results in increased uptake of Lamivudine

NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436

G

solute carrier family 22 member 2

increases uptake

ISO

SLC22A2 protein results in increased uptake of Lamivudine

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

G

solute carrier family 22 member 3

increases uptake

ISO

SLC22A3 protein results in increased uptake of Lamivudine

NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353

G

solute carrier family 25 member 12

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A12 mRNA

NCBI chr 3:76,504,868...76,599,536
Ensembl chr 3:76,504,868...76,599,536

G

solute carrier family 25 member 15

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNA

NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321

G

solute carrier family 25 member 19

multiple interactions

ISO

SLC25A19 protein affects the susceptibility to [Stavudine co-treated with Lamivudine co-treated with Indinavir]; SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir]
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A19 mRNA

PMID:15951836 PMID:18313992

NCBI chr10:101,353,426...101,366,551
Ensembl chr10:101,350,106...101,366,351

G

solute carrier family 25 member 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A2 mRNA

NCBI chr18:29,704,182...29,707,563
Ensembl chr18:29,703,871...29,708,827

G

solute carrier family 25 member 20

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A20 mRNA

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 25 member 29

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A29 mRNA

NCBI chr 6:133,506,403...133,517,322
Ensembl chr 6:133,506,331...133,517,827

G

solute carrier family 25 member 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A3 mRNA

NCBI chr 7:27,499,164...27,506,685
Ensembl chr 7:27,499,165...27,506,309

G

solute carrier family 25 member 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A4 mRNA

NCBI chr16:52,805,521...52,809,316
Ensembl chr16:52,805,523...52,811,700

G

solute carrier family 28 member 1

multiple interactions

ISO

Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]

NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:144,490,623...144,531,544

G

solute carrier family 31 member 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 3 member 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 40 member 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 6 member 4

multiple interactions
increases expression

ISO

[Lamivudine co-treated with IFNA2 protein] results in increased expression of SLC6A4 mRNA; Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Lamivudine results in increased expression of and results in increased activity of SLC6A4 protein
Lamivudine results in increased expression of SLC6A4 mRNA

NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056

G

serine peptidase inhibitor, Kazal type 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of SPINK5 mRNA

NCBI chr18:36,515,347...36,584,038
Ensembl chr18:36,515,347...36,583,799

G

steroidogenic acute regulatory protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

stanniocalcin 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of STC2 mRNA

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447

G

SUB1 regulator of transcription

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA

NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:62,732,736...62,747,679

G

transcription elongation factor A1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of TCEA1 mRNA

NCBI chr 5:19,414,351...19,466,629
Ensembl chr15:12,831,339...12,834,156
Ensembl chr 5:12,831,339...12,834,156

G

transforming growth factor, beta 1

decreases expression

ISO

Lamivudine results in decreased expression of TGFB1 protein

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

translocase of inner mitochondrial membrane 17b

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNA

NCBI chr X:17,268,257...17,275,424
Ensembl chr X:17,268,257...17,275,563

G

translocase of inner mitochondrial membrane 23

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM23 mRNA

NCBI chr16:7,416,590...7,442,681
Ensembl chr16:7,416,597...7,442,658
Ensembl chr 3:7,416,597...7,442,658
Ensembl chr 6:7,416,597...7,442,658

G

TIMP metallopeptidase inhibitor 1

decreases expression

ISO

Lamivudine results in decreased expression of TIMP1 protein

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

thymidine kinase 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of TK2 mRNA

NCBI chr19:713,043...737,345
Ensembl chr19:715,318...738,355

G

tumor necrosis factor

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tribbles pseudokinase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 42

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TRIM42 mRNA

NCBI chr 8:106,781,847...106,802,764
Ensembl chr 8:106,781,851...106,802,764

G

twinkle mtDNA helicase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of TWNK mRNA

NCBI chr 1:253,817,074...253,823,958
Ensembl chr 1:253,817,564...253,824,162

G

thymidylate synthetase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA

NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097

G

tyrosinase-related protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYRP1 mRNA

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:100,327,125...100,345,657

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNA

NCBI chr 7:65,700,016...65,705,382
Ensembl chr 7:65,700,029...65,705,558

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA

PMID:17526437 PMID:18313992

NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:118,468,200...118,479,964

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNA

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

G

voltage-dependent anion channel 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDAC1 mRNA

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vitamin D receptor

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDR mRNA

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

vacuolar protein sorting 4 homolog B

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in decreased expression of VPS4B mRNA

NCBI chr13:23,421,758...23,446,848
Ensembl chr13:23,421,758...23,446,973

G

tryptophanyl-tRNA synthetase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

Wnt family member 10A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA

NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067

G

tyrosyl-tRNA synthetase 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine] results in increased expression of YARS1 mRNA

NCBI chr 5:146,820,163...146,848,377
Ensembl chr 5:146,819,358...146,848,377

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects binding

ISO

ledipasvir binds to ABCG2 protein

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

killer cell lectin like receptor C1

decreases expression

ISO

ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells

RGD

NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:164,828,163...164,838,464

G

natural cytotoxicity triggering receptor 1

affects expression

ISO

ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells

RGD

NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:78,659,262...78,703,273

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Lopinavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lopinavir results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101 PMID:24014644

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily C member 2

increases abundance
increases secretion

ISO

ABCC2 protein alternative form results in increased abundance of Lopinavir
ABCC2 protein results in increased secretion of Lopinavir

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

adiponectin, C1Q and collagen domain containing

multiple interactions
decreases expression

ISO

diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of ADIPOQ protein]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

catalase

multiple interactions

ISO

CAT protein inhibits the reaction [Lopinavir results in decreased activity of CYP3A4 protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

ISO

diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

increases expression

ISO

Lopinavir results in increased expression of CCL3 protein

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

ISO

Lopinavir results in decreased activity of CYP3A4 protein
CAT protein inhibits the reaction [Lopinavir results in decreased activity of CYP3A4 protein]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

heme oxygenase 1

multiple interactions
increases expression

ISO

Lopinavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]
Lopinavir results in increased expression of HMOX1 mRNA; Lopinavir results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

intercellular adhesion molecule 1

increases expression

ISO

Lopinavir results in increased expression of ICAM1 protein

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 1 beta

increases expression

ISO

Lopinavir results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
increases expression

ISO

diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

leptin

multiple interactions
decreases expression

ISO

diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein]

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

lamin A/C

increases farnesylation

ISO

Lopinavir results in increased farnesylation of LMNA protein alternative form

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

RB transcriptional corepressor 1

affects phosphorylation

ISO

Lopinavir affects the phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

tumor necrosis factor

increases expression

ISO

Lopinavir results in increased expression of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

zinc metallopeptidase STE24

decreases activity

ISO

Lopinavir results in decreased activity of ZMPSTE24 protein

NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:139,913,671...139,945,532

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actinin alpha 2

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 protein

NCBI chr17:62,835,055...62,902,331
Ensembl chr17:62,812,988...62,903,552

G

C-C motif chemokine ligand 3

multiple interactions

ISO

maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

multiple interactions

ISO

maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine receptor 5

multiple interactions

ISO

maraviroc binds to and results in decreased activity of CCR5 protein; maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]; maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein]

PMID:15644495 PMID:21128663

NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:132,629,683...132,637,594

G

collagen type I alpha 1 chain

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

myosin heavy chain 6

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

ryanodine receptor 2

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of RYR2 mRNA

NCBI chr17:63,081,527...63,667,141
Ensembl chr17:63,081,527...63,666,705

G

troponin T2, cardiac type

multiple interactions

ISO

[BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 protein

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

N-acetyl-L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of A1BG mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of A1BG mRNA]

NCBI chr 7:94,383,333...94,387,922
Ensembl chr 7:94,383,333...94,387,496

G

ATP binding cassette subfamily A member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of ABCA1 promoter]

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily A member 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA5 mRNA]

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,739,610...95,808,424

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO
EXP

Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ABCB1]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]

PMID:10636889 PMID:18474546 PMID:22914566 PMID:23867903 PMID:25824409

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]; Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]]

PMID:11820781 PMID:15473893 PMID:22914566 PMID:23867903

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA]
Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCC2 protein]

PMID:22914566 PMID:23867903 PMID:34303734

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein]

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily G member 1

decreases expression

ISO

Acetylcysteine results in decreased expression of ABCG1 mRNA

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA]

NCBI chr 8:53,508,005...53,525,314
Ensembl chr 8:53,508,005...53,523,571

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein]

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acetylcholinesterase

multiple interactions
affects response to substance

EXP
ISO

[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Cadmium results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]
ACHE protein affects the susceptibility to Acetylcysteine
Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

PMID:20399762 PMID:20688495 PMID:26769589 PMID:27087133 PMID:27163631 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

acyl-CoA thioesterase 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACOT5 mRNA

NCBI chr 6:109,433,062...109,439,846
Ensembl chr 6:109,453,391...109,461,035
Ensembl chr 6:109,453,391...109,461,035

G

acid phosphatase 3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACP3 mRNA

NCBI chr 8:113,784,372...113,833,033
Ensembl chr 8:113,785,032...113,833,033

G

acyl-CoA synthetase medium-chain family member 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSM5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACSM5 mRNA]

NCBI chr 1:183,302,241...183,328,175
Ensembl chr 1:183,294,105...183,329,925

G

acyl-CoA synthetase short-chain family member 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA

NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Acetylcysteine results in decreased expression of ACTA2 mRNA; Acetylcysteine results in decreased expression of ACTA2 protein
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ACTA2 mRNA]
Acetylcysteine inhibits the reaction [[bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]

PMID:16757516 PMID:21134390 PMID:32659284 PMID:33131013 PMID:35622622 More...

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

ADAM metallopeptidase domain 17

multiple interactions

ISO

Acetylcysteine inhibits the reaction [necrostatin-1 results in increased expression of ADAM17 mRNA]; Acetylcysteine inhibits the reaction [necrostatin-1 results in increased expression of ADAM17 protein]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

ADAM metallopeptidase domain 33

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ADAM33 mRNA]

NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:138,724,046...138,736,347

G

adhesion G protein-coupled receptor B2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB2 mRNA

NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:147,611,580...147,646,726

G

adhesion G protein-coupled receptor B3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB3 mRNA

NCBI chr 9:34,917,474...35,645,350
Ensembl chr 9:34,917,474...35,644,811

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Ethanol results in increased expression of ADH1 mRNA]

NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291

G

adiponectin, C1Q and collagen domain containing

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]]

PMID:17471172 PMID:21912612

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adiponectin receptor 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]]

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

angiotensinogen

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]

PMID:15849355 PMID:30703374

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 1a

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

aryl hydrocarbon receptor

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of AHR protein
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of and affects the localization of AHR protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of AHR protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]

PMID:18022818 PMID:21569840 PMID:31551408 PMID:35123993

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

allograft inflammatory factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of AIF1 protein]]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [bisphenol A affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of AIFM1 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein]

PMID:18034189 PMID:18412143 PMID:18506790 PMID:18951928 PMID:19679660 More...

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

absent in melanoma 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of AIM2 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of AIM2 protein]

NCBI chr13:88,397,516...88,439,325
Ensembl chr13:88,404,048...88,439,318

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

ISO

Acetylcysteine results in decreased expression of AIMP1 mRNA

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:223,825,931...223,849,994

G

aldo-keto reductase family 1 member B15

multiple interactions

EXP

Acetylcysteine inhibits the reaction [arsenite results in increased expression of AKR1B8 protein]

NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349

G

aldo-keto reductase family 1, member C3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA]

PMID:18829485 PMID:21787718

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

AKT serine/threonine kinase 1

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of and affects the localization of AKT1 protein]; Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [celastrol methyl ester results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [morusin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [N-arachidonoylalanine results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [oenothein B results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [oxophenylarsine results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [synaptamide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [tubocapsenolide A results in increased degradation of AKT1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein
N-acetyl=L-cysteine inhibits the reaction [ethanol decreases phosphorylation of Akt1 protein in the liver]
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]
Acetylcysteine inhibits the reaction [cadmium acetate results in decreased expression of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AKT1 mRNA]

CTD
RGD

PMID:12168106 PMID:12614848 PMID:16137721 PMID:16731823 PMID:18442981 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT2 protein]

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

AKT serine/threonine kinase 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of AKT3 protein]

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

aminolevulinate dehydratase

multiple interactions

EXP

Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]]

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

albumin

multiple interactions
affects binding

EXP

Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in decreased expression of MFN2 protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in increased abundance of Hydrogen Peroxide]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [Mustard Gas results in increased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]
N-acetyl-L-cysteine binds Alb protein in serum

CTD
RGD

PMID:11428623 PMID:20804811 PMID:24485406 PMID:27997345 PMID:12458670

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 2 family member

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

ALK receptor tyrosine kinase

multiple interactions

ISO

Acetylcysteine affects the phosphorylation of and affects the activity of ALK protein mutant form

NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:28,632,197...29,349,721

G

alkB homolog 5, RNA demethylase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ALKBH5 mRNA]
Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of ALKBH5 mRNA]

PMID:31004932 PMID:34425375

NCBI chr10:45,844,411...45,865,853
Ensembl chr10:45,843,656...45,869,658

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

alpha-methylacyl-CoA racemase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA]

NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:61,670,475...61,685,379

G

angiogenin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of ANG protein]

NCBI chr15:26,786,233...26,796,883
Ensembl chr15:26,786,065...26,801,106

G

angiopoietin 1

decreases secretion

ISO

Acetylcysteine results in decreased secretion of ANGPT1 protein

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

angiopoietin-like 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681

G

ankyrin repeat domain 29

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANKRD29 mRNA

NCBI chr18:3,711,052...3,768,997
Ensembl chr18:3,711,059...3,769,098

G

annexin A5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of ANXA5 protein]; Acetylcysteine inhibits the reaction [Tin Fluorides results in increased expression of ANXA5 protein]

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400

G

amine oxidase, copper containing 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]

NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:79,143,126...79,162,704

G

apoptotic peptidase activating factor 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]
Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of APAF1 protein]; Acetylcysteine inhibits the reaction [naringin results in decreased expression of APAF1 protein]

PMID:15877105 PMID:19477266 PMID:35396826 PMID:39056589

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]

PMID:12231548 PMID:17938202

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

apurinic/apyrimidinic endodeoxyribonuclease 2

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
Acetylcysteine results in decreased expression of APEX2 mRNA

NCBI chr X:22,914,943...22,937,713
Ensembl chr X:22,914,944...22,936,011

G

aph-1 homolog B, gamma secretase subunit

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of APH1B mRNA

NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:76,310,380...76,331,428

G

apolipoprotein E

increases expression
multiple interactions

EXP

Acetylcysteine results in increased expression of APOE mRNA
Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of APOE mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of APOE mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased expression of APOE mRNA]

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein]

PMID:12684028 PMID:28004443

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 2

increases expression

EXP

Acetylcysteine results in increased expression of AQP2 protein

NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319

G

androgen receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR mRNA]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR protein]

PMID:16928829 PMID:18829485

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

ARF like GTPase 13A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARL13A mRNA

NCBI chr X:101,673,637...101,699,986
Ensembl chr X:101,673,652...101,699,984

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

arrestin domain containing 3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

ADP-ribosyltransferase 4

decreases expression

ISO

Acetylcysteine results in decreased expression of ART4 mRNA

NCBI chr 4:171,468,415...171,482,435
Ensembl chr 4:171,471,534...171,481,868

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

astacin like metalloendopeptidase

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASTL mRNA

NCBI chr 3:135,016,444...135,032,177
Ensembl chr 3:135,016,444...135,032,177

G

activating transcription factor 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]

PMID:19654923 PMID:22288910

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of ATF3 protein]

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

multiple interactions
decreases expression
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [bisphenol S results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]; ginsenoside Rg3 promotes the reaction [Acetylcysteine inhibits the reaction [Glucose results in increased expression of ATF4 protein]]
[Acetylcysteine co-treated with Trichloroethylene] results in increased expression of ATF4 mRNA; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]
Acetylcysteine results in decreased expression of ATF4 protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]
Acetylcysteine results in increased expression of ATF4 protein

PMID:15788408 PMID:19722195 PMID:21266191 PMID:24291486 PMID:25451595 More...

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [hydroquinone results in decreased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased expression of ATF6 protein]; Acetylcysteine results in increased metabolism of and results in increased activity of ATF6 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
Acetylcysteine inhibits the reaction [Arecoline results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]

PMID:18077580 PMID:19722195 PMID:21198628 PMID:21911445 PMID:24291486 More...

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

autophagy related 10

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA]

NCBI chr 2:23,843,695...24,133,459
Ensembl chr 2:23,844,482...24,133,368

G

autophagy related 12

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG12 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]

PMID:20543569 PMID:24614525 PMID:29307831 PMID:30205151 PMID:33146789 More...

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:41,635,835...41,649,261

G

autophagy related 14

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA]

NCBI chr15:23,275,457...23,306,817
Ensembl chr15:23,275,457...23,306,815

G

autophagy related 16-like 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG16L1 protein]

NCBI chr 9:95,869,839...95,905,354
Ensembl chr 9:95,869,865...95,905,357

G

autophagy related 16-like 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ATG16L2 mRNA]

NCBI chr 1:165,100,946...165,123,307
Ensembl chr 1:165,102,936...165,115,473

G

autophagy related 4A, cysteine peptidase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein]

NCBI chr X:109,453,712...109,553,758
Ensembl chr X:109,453,689...109,553,760

G

autophagy related 4C, cysteine peptidase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of ATG4C mRNA]

NCBI chr 5:118,977,594...119,050,894
Ensembl chr 5:118,982,918...119,052,695

G

autophagy related 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]

PMID:20543569 PMID:24614525 PMID:28600122 PMID:29307831 PMID:30205151 More...

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

autophagy related 7

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATG7 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA]

PMID:29247770 PMID:29307831 PMID:30205151 PMID:31319114 PMID:33462182

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:149,391,390...149,598,319

G

autophagy related 9A

multiple interactions

ISO

[Chloroquine co-treated with Acetylcysteine] results in decreased expression of ATG9A mRNA

NCBI chr 9:84,126,071...84,136,723
Ensembl chr 9:84,126,071...84,136,666

G

ATM serine/threonine kinase

multiple interactions
increases phosphorylation

ISO
EXP

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
Acetylcysteine affects the reaction [yttrium chloride affects the expression of ATM protein]
Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATM protein]
Acetylcysteine results in increased phosphorylation of ATM protein

PMID:15489221 PMID:23274516 PMID:24792323 PMID:26451628 PMID:31168028 More...

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

antioxidant 1 copper chaperone

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATOX1 mRNA]

NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]

NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:191,709,311...191,737,425

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

increases expression
multiple interactions

ISO
EXP

Acetylcysteine results in increased expression of ATP2A2 mRNA
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATP2A2 mRNA]
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]

PMID:10625299 PMID:16084531 PMID:17005195 PMID:36315628

NCBI chr12:39,733,519...39,782,942
Ensembl chr12:39,733,458...39,782,934

G

ATP synthase F1 subunit alpha

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP5F1A mRNA]

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

ATPase H+ transporting V0 subunit D1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATP6V0D1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATP6V0D1 mRNA]

PMID:29307831 PMID:31319114

NCBI chr19:50,313,268...50,357,248
Ensembl chr19:50,313,273...50,357,395

G

ATPase H+ transporting V0 subunit D2

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ATP6V0D2 mRNA
[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of ATP6V0D2 mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of ATP6V0D2 mRNA]

PMID:22129741 PMID:30742845 PMID:38896780

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

ATR serine/threonine kinase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein]

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

ataxin 1

affects localization
multiple interactions

ISO

Acetylcysteine affects the localization of ATXN1 protein mutant form
Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]

NCBI chr17:18,943,397...19,354,751
Ensembl chr17:19,208,200...19,356,790

G

aurora kinase B

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein]

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

beta-2 microglobulin

decreases response to substance
multiple interactions

ISO

Acetylcysteine results in decreased susceptibility to B2M protein modified form
Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species]

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

Beta-1,3-galactosyltransferase 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA

NCBI chr11:49,053,959...49,100,398
Ensembl chr11:49,006,560...49,101,283

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GNT9 mRNA

NCBI chr19:50,039,649...50,042,206
Ensembl chr19:50,030,866...50,043,339

G

BTB domain and CNC homolog 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [alpha-pyrrolidinononanophenone analog results in increased expression of BACH1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of BACH1 protein]

PMID:19350554 PMID:38040126

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAD protein]
Acetylcysteine results in increased expression of BAD mRNA

PMID:21310227 PMID:22245127 PMID:26332274

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BAG cochaperone 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of BAG3 mRNA]

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

BCL2-antagonist/killer 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAK1]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAK1 mRNA]

PMID:21533816 PMID:21549813 PMID:22085843 PMID:23339468 PMID:28296042

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BARX homeobox 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BARX2 mRNA

NCBI chr 8:38,509,277...38,576,978
Ensembl chr 8:38,509,277...38,576,978

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of BAX protein]]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases expression of BAX protein in the stomach)
Acetylcysteine affects the reaction [lead acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of BAX mRNA]
Acetylcysteine results in increased expression of BAX mRNA
Acetylcysteine results in decreased expression of BAX protein
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased localization of BAX protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of BAX protein]; Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of BAX protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [gingerol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [glabridin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [naringin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of BAX protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BAX protein]]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased expression of BAX protein]
Acetylcysteine results in increased expression of BAX protein

CTD
RGD

PMID:11166918 PMID:11341981 PMID:15496615 PMID:15735709 PMID:16169029 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]
Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of BBC3 protein]

PMID:24291486 PMID:32540572

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

brain enriched myelin associated protein 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCAS1 mRNA

NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:179,551,704...179,637,743

G

butyrylcholinesterase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of BCHE protein]
Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]; Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of BCHE protein]

PMID:27087133 PMID:34425170

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
decreases response to substance

ISO
EXP

Acetylcysteine results in decreased expression of BCL2 protein
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases expression of BCL2 protein in the stomach)
Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of BCL2 protein]
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; [saikosaponin D co-treated with Acetylcysteine] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of BCL2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [CSC-3436 results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [glabridin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Propofol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [surfactin peptide results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of BCL2 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL2 protein]]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in decreased expression of BCL2 protein]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of BCL2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]]
BCL2 results in decreased susceptibility to Acetylcysteine

CTD
RGD

PMID:11341981 PMID:17041759 PMID:17395010 PMID:17542780 PMID:18077580 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]
Acetylcysteine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]
Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [fucoxanthin results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [nickel acetate results in increased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of BCL2L1 protein]

PMID:18281123 PMID:18483861 PMID:20594983 PMID:21310227 PMID:22085843 More...

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased expression of BCL2L11 protein]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

BCL6, transcription repressor

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA

NCBI chr11:90,358,753...90,382,049
Ensembl chr11:90,358,753...90,382,047

G

bradykinin receptor B1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Capsaicin results in increased expression of BDKRB1 mRNA]

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:130,275,478...130,280,973

G

brain-derived neurotrophic factor

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased secretion of BDNF protein]
Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of BDNF protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of BDNF protein]

PMID:16553631 PMID:26138014 PMID:38642822

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

beclin 1

multiple interactions

ISO
EXP

[Chloroquine co-treated with Acetylcysteine] results in increased expression of BECN1 mRNA; Acetylcysteine inhibits the reaction [alpha-pyrrolidinononanophenone results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of and results in increased phosphorylation of BECN1 protein]; Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of BECN1 mRNA]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Vorinostat results in increased expression of BECN1 protein]
Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of BECN1 protein]
Acetylcysteine inhibits the reaction [[Air Pollutants, Occupational results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of BECN1 protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of BECN1 protein]

PMID:20543569 PMID:21216964 PMID:24614525 PMID:26588882 PMID:26804764 More...

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

bone gamma-carboxyglutamate protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

BH3 interacting domain death agonist

multiple interactions

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of BID protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BID protein]
Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BID protein]

PMID:16169029 PMID:17574045 PMID:21310227 PMID:23660334 PMID:23711929 More...

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

BCL2-interacting killer

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of BIK protein]

NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317

G

baculoviral IAP repeat-containing 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein]

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein]

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [CSC-3436 results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [sepantronium results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BIRC5 protein]

PMID:21741372 PMID:23711929 PMID:25034532 PMID:31837377 PMID:34599545

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

basic helix-loop-helix ARNT like 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

bone morphogenetic protein 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BMP5 mRNA

NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:85,396,925...85,520,189

G

bone morphogenetic protein 7

multiple interactions

EXP

[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of BMP7 mRNA

NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:182,052,337...182,135,137

G

BCL2 interacting protein 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of BNIP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]

PMID:19442826 PMID:36739042

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of BNIP3L protein]

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

bisphosphoglycerate mutase

decreases expression

ISO

Acetylcysteine results in decreased expression of BPGM mRNA

NCBI chr 4:64,106,809...64,135,749
Ensembl chr 4:64,106,804...64,135,627

G

BTG anti-proliferation factor 1

decreases expression

ISO

Acetylcysteine results in decreased expression of BTG1 mRNA

NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406

G

complement C3

multiple interactions

EXP

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of C3 protein modified form]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C3 protein]

PMID:20946910 PMID:32924446

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

complement C5

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of C5 protein]

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:38,668,174...38,759,468

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CACNA1G mRNA

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634

G

calpain 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN1 protein]

NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445

G

calpain 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of CAPN2 protein]

NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625

G

caspase 1

multiple interactions
increases cleavage

ISO
EXP

[Acetylcysteine co-treated with Cobalt] results in decreased expression of CASP1 protein; Acetylcysteine affects the reaction [diallyl trisulfide results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased cleavage of CASP1 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [Cobalt results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [hydroquinone results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of and results in increased cleavage of CASP1 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form]; Acetylcysteine inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]]
Acetylcysteine results in increased cleavage of CASP1 protein
Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Ceruletide results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP1 protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased cleavage of CASP1 protein]]
[Acetylcysteine co-treated with (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid] inhibits the reaction [Acetaminophen results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide inhibits the reaction [anthrax toxin results in increased cleavage of CASP1 protein]]; Acetylcysteine inhibits the reaction [bisphenol A results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [bosutinib results in increased activity of CASP1 protein]; Acetylcysteine inhibits the reaction [bosutinib results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [ponatinib results in increased activity of CASP1 protein]; Acetylcysteine inhibits the reaction [ponatinib results in increased expression of CASP1 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]

PMID:23940760 PMID:24337744 PMID:24885895 PMID:25929180 PMID:26079697 More...

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Arecoline results in increased cleavage of CASP12 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of and results in increased activity of CASP12 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of CASP12 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP12 protein]]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP12 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP12 protein]; ginsenoside Rg3 promotes the reaction [Acetylcysteine inhibits the reaction [Glucose results in increased cleavage of CASP12 protein]]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of CASP12 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP12 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP12 protein]

PMID:18077580 PMID:21145380 PMID:21616140 PMID:25451595 PMID:28296042 More...

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 14

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP14 protein]

NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:11,580,339...11,583,171

G

caspase 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]
Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP2 protein]
Acetylcysteine inhibits the reaction [[CASP2 protein affects the susceptibility to Rotenone] which results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased cleavage of CASP2 protein]

PMID:15158148 PMID:17041759 PMID:21216964 PMID:30408460

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases cleavage
multiple interactions
increases activity
increases expression
decreases activity

ISO
EXP

Acetylcysteine results in increased cleavage of CASP3 protein
N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP3 protein in stomach]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP3 protein in the stomach)
Acetylcysteine results in increased activity of CASP3 protein
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [arsenite results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Estradiol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP3]; Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Lead results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [menadione epoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Propranolol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CASP3 protein modified form]
[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [6-iodo-5-hydroxy-eicosatrienoic acid, delta-lactone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein]; Acetylcysteine inhibits the reaction [[alpha-pyrrolidinononanophenone analog co-treated with Tretinoin] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Naphthalimides co-treated with Spermidine] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[Pentachlorophenol co-treated with copper-1,10-phenanthroline] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Vitamin K 2 co-treated with Arsenic Trioxide] results in increased expression of CASP3]; Acetylcysteine inhibits the reaction [ABBV-744 results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [alpha-pyrrolidinononanophenone analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [alpha-pyrrolidinononanophenone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [butein results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [chromium tripicolinate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [dimethoxycurcumin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Eosine I Bluish results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [fenpyroximate results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T analog results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [glabridin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [hesperetin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [isoliensinine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [manumycin results in increased activity of CASP3]; Acetylcysteine inhibits the reaction [menadione epoxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [naringin results in increased expression of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [platycodin D results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Prodigiosin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Reactive Oxygen Species results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [sulforaphane promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [surfactin peptide results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased cleavage of CASP3 protein]; Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP3 protein]; Acetylcysteine promotes the reaction [sinularin results in increased cleavage of CASP3 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased cleavage of CASP3 protein]; Oxygen deficiency affects the reaction [Acetylcysteine results in increased activity of CASP3 protein]
Acetylcysteine results in increased expression of CASP3 protein modified form
Acetylcysteine results in decreased activity of CASP3 protein
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Acetylcysteine affects the reaction [nonylphenol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of and results in increased cleavage of CASP3 protein]]; Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP3 protein]; Acetylcysteine inhibits the reaction [Arecoline results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of and results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [nitrofen results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Acetylcysteine results in increased expression of CASP3 protein modified form]

CTD
RGD

PMID:11969376 PMID:12168106 PMID:12750841 PMID:12754411 PMID:14660655 More...

RGD:127284886, RGD:127284846

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CASP4 mRNA]
Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of CASP4 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]
Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA]

PMID:16137721 PMID:19477266 PMID:22922937 PMID:25341683

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 6

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP6 protein]
Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP6 protein]; Acetylcysteine inhibits the reaction [surfactin peptide results in increased cleavage of and results in increased activity of CASP6 protein]

PMID:15158148 PMID:19954742 PMID:24157283 PMID:37146930

NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726

G

caspase 7

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP7 mRNA]
Acetylcysteine results in decreased expression of CASP7 protein modified form
Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [geldanamycin results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [methylselenic acid results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP7 protein modified form]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP7 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP7 protein]
Acetylcysteine inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP7 protein]

PMID:17136323 PMID:19771260 PMID:20594983 PMID:21145380 PMID:21549813 More...

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

multiple interactions

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of CASP8 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of CASP8 protein]]; Acetylcysteine inhibits the reaction [cannabidiol hydroxyquinone results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP8 protein]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP8 protein in the stomach)
[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased activity of CASP8 protein]; [Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of CASP8 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP8]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of CASP8 protein]
[Acetylcysteine co-treated with cannabidivarin] results in increased activity of CASP8 protein; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in decreased expression of CASP8 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in decreased expression of CASP8 protein]]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP8 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased activity of and results in increased cleavage of CASP8 protein]

CTD
RGD

PMID:16169029 PMID:17574045 PMID:18791325 PMID:19014919 PMID:19477266 More...

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases activity
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Arecoline results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [monomethylarsonous acid results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; Acetylcysteine inhibits the reaction [T-2 Toxin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of CASP9 protein]
Acetylcysteine results in increased activity of CASP9 protein
N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid increases cleavage of CASP9 protein in stomach]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside increases cleavage of CASP9 protein in the stomach)
Acetylcysteine results in increased expression of CASP9 protein; Acetylcysteine results in increased expression of CASP9 protein modified form
Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of CASP9]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]
[Glucose deficiency co-treated with Acetylcysteine] results in increased activity of CASP9 protein; [saikosaponin D co-treated with Acetylcysteine] results in decreased expression of CASP9 protein; Acetylcysteine affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Acetylcysteine inhibits the reaction [10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [cannabidivarin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in decreased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [ganoderic acid analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [ganoderic acid T results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [ochratoxin A results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [oenothein B results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Propofol results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [Soot analog results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased expression of CASP9 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of CASP9 protein]

CTD
RGD

PMID:15158148 PMID:15496615 PMID:16169029 PMID:17309078 PMID:17574045 More...

RGD:127284886, RGD:127284846

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity
increases expression

EXP
ISO

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Acetylcysteine inhibits the reaction [Carmustine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethylnitrosamine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Zinc results in decreased expression of CAT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Particulate Matter results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [ceric oxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Chlorine results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos affects the activity of CAT protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Smoke analog results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of CAT mRNA]; CAT protein inhibits the reaction [Acetylcysteine results in increased abundance of Hydrogen Peroxide]
Acetylcysteine results in decreased activity of CAT protein
Acetylcysteine results in increased expression of CAT protein
Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased activity of CAT protein]

PMID:7491977 PMID:16169029 PMID:19840221 PMID:19853593 PMID:20332008 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of CAV1
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of CAV1 protein]; Acetylcysteine inhibits the reaction [Rosiglitazone results in increased expression of CAV1]; Acetylcysteine results in increased ubiquitination of and results in increased degradation of CAV1 protein; Hydrogen Peroxide inhibits the reaction [Acetylcysteine results in increased ubiquitination of and results in increased degradation of CAV1 protein]

PMID:18507034 PMID:21148404 PMID:35349355

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

cystathionine beta synthase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Rotenone results in decreased expression of CBS protein]

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066

G

coiled-coil domain containing 85C

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased localization of CCDC85C protein]

NCBI chr 6:132,877,851...132,948,744
Ensembl chr 6:132,879,562...132,948,623

G

C-C motif chemokine ligand 11

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCL11 mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CCL11 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL11 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of CCL11 protein]

PMID:12576300 PMID:22129741 PMID:26138014

NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575

G

C-C motif chemokine ligand 17

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL17 protein]

NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895

G

C-C motif chemokine ligand 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CCL2 mRNA]
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in increased secretion of CCL2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL2 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CCL2 protein]]
Acetylcysteine affects the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]

PMID:10541287 PMID:11124598 PMID:15139008 PMID:17529908 PMID:18303122 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

decreases expression

ISO

Acetylcysteine results in decreased expression of CCL20 mRNA

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 22

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of CCL22 mRNA]

NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359

G

C-C motif chemokine ligand 24

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CCL24 protein]

NCBI chr12:26,737,423...26,741,420
Ensembl chr12:26,737,439...26,750,924

G

C-C motif chemokine ligand 3

multiple interactions
decreases secretion

ISO

[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CCL3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased secretion of CCL3 protein]]; Acetylcysteine promotes the reaction [Polymyxin B results in decreased secretion of CCL3 protein]; MYD88 protein affects the reaction [[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CCL3 mRNA]]; Polymyxin B promotes the reaction [Acetylcysteine results in decreased secretion of CCL3 protein]

PMID:21765237 PMID:28555929

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CCL5 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CCL5 mRNA]

PMID:10495789 PMID:11167962 PMID:26138014 PMID:33146789

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cellular communication network factor 1

multiple interactions
increases expression

ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]; Cycloheximide inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]
Acetylcysteine results in increased expression of CCN1 mRNA; Acetylcysteine results in increased expression of CCN1 protein

NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883

G

cellular communication network factor 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CCNA1 protein]

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin A2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNA2 protein]
Acetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased expression of CCNA2 protein]

PMID:24909818 PMID:28506552

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CCNB1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CCNB1 protein]; Acetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CCNB1 protein]

PMID:24909818 PMID:25633853 PMID:28548367 PMID:29128613

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [[Vorinostat co-treated with Butyrates] results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of CCND1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [naringin results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of CCND1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCND1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 protein]
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in decreased expression of CCND1 protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of CCND1 protein]

PMID:15173093 PMID:15897899 PMID:17602960 PMID:18563748 PMID:19409983 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of CCND2 protein]; Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CCND2 mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCND2 mRNA]
Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND2 protein]
Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCND2 mRNA]

PMID:19615393 PMID:23077170 PMID:26332274 PMID:33485121 PMID:34627931

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin D3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [thymoquinone results in decreased expression of CCND3 protein]

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin E1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCNE1 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CCNE1 mRNA]

PMID:15945272 PMID:23077170 PMID:24909818

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin E2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

CD14 molecule

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Iron deficiency results in increased expression of CD14 protein]

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD36 molecule

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CD36 mRNA]
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CD36 protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD36 protein]; Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of CD36 mRNA]; Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of CD36 protein]
Acetylcysteine inhibits the reaction [[bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased expression of CD36 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of CD36 mRNA]; Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of CD36 protein]; CD36 mRNA promotes the reaction [Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]

PMID:22824115 PMID:26187465 PMID:33007364 PMID:35622622 PMID:36534932

NCBI chr 4:18,209,088...18,302,142

G

CD40 ligand

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]
Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]

PMID:19477266 PMID:27634759

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:140,164,302...140,176,475

G

CD86 molecule

multiple interactions

ISO

Acetylcysteine affects the reaction [Dinitrochlorobenzene affects the expression of CD86 protein]; Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]

PMID:19033392 PMID:19641517 PMID:20417223 PMID:20457211 PMID:30842373

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

cell division cycle 25C

multiple interactions

ISO

Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDC25C protein modified form]

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cadherin 1

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CDH1 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH1 protein]; Acetylcysteine inhibits the reaction [DDT results in decreased expression of CDH1 mRNA]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of CDH1 protein]
Acetylcysteine results in increased expression of CDH1 protein
Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [SHC1 protein results in decreased expression of CDH1 protein]

PMID:18791180 PMID:22648416 PMID:24820114 PMID:28284859 PMID:32659284 More...

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 11

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDH11 mRNA

NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140

G

cadherin 13

decreases expression

ISO

Acetylcysteine results in decreased expression of CDH13 mRNA

NCBI chr19:63,258,251...64,296,122
Ensembl chr19:63,258,122...64,296,119

G

cadherin 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein]
Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of CDH2 protein]
Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDH2 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of CDH2 mRNA]

PMID:23876460 PMID:24820114 PMID:28284859 PMID:38488660

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cadherin 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in decreased expression of CDH5 protein]

NCBI chr19:821,875...860,931
Ensembl chr19:822,464...860,822

G

cyclin-dependent kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CDK1 protein]
Acetylcysteine inhibits the reaction [ovatodiolide results in decreased expression of CDK1 protein]; Acetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CDK1 protein]

PMID:25633853 PMID:28548367 PMID:39276908

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [naringin results in decreased expression of CDK2 protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in decreased expression of CDK2 protein]

PMID:39056589 PMID:39276908

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Methoxychlor results in decreased expression of CDK4 mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CDK4 mRNA]
Acetylcysteine inhibits the reaction [tubocapsenolide A results in increased degradation of CDK4 protein]

PMID:18442981 PMID:19615393 PMID:23077170

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 7

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CDK7 mRNA]

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of CDKN1A]; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [ethylenimine quinone results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]; IL7R mRNA alternative form promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN1A mRNA]]
Acetylcysteine results in decreased expression of CDKN1A mRNA
Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CDKN1A protein]; Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of CDKN1A protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1A protein]

PMID:8943236 PMID:9343371 PMID:12208374 PMID:15496615 PMID:15978937 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

EXP
ISO

Acetylcysteine results in increased expression of CDKN1B protein
Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of CDKN1B protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]

PMID:17602960 PMID:18022818 PMID:30917517

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [EZH2 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [KDM2A protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [TET1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN2A mRNA]; IL7R mRNA alternative form promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN2A mRNA]]
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CDKN2A protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]

PMID:31551408 PMID:32473187 PMID:35303175

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

CCAAT/enhancer binding protein alpha

multiple interactions

ISO

Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CEBPA protein]

PMID:27117918 PMID:35622622

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein epsilon

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of CEBPE mRNA]]

NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

ISO

Acetylcysteine inhibits the reaction [CSC-3436 results in decreased expression of CFLAR protein]; Acetylcysteine inhibits the reaction [gingerol results in decreased expression of CFLAR protein]; Acetylcysteine inhibits the reaction [lactucin results in decreased expression of CFLAR protein]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]

PMID:25034532 PMID:25619640 PMID:34302634 PMID:34599545

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

CF transmembrane conductance regulator

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR mRNA]; Acetylcysteine inhibits the reaction [Ozone results in decreased expression of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

cyclic GMP-AMP synthase

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of CGAS protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of CGAS protein]]

NCBI chr 8:88,172,559...88,187,538
Ensembl chr 8:88,174,512...88,185,859

G

choline O-acetyltransferase

increases expression
multiple interactions

EXP

Acetylcysteine results in increased expression of CHAT protein
[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein; Tobacco Smoke Pollution inhibits the reaction [[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in increased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

checkpoint kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CHEK1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]
Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of CHEK1 protein modified form]

PMID:15489221 PMID:25633853 PMID:33971260

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of CHEK2 protein modified form]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased phosphorylation of CHEK2 protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]
Acetylcysteine results in increased expression of CHEK2 protein

PMID:15489221 PMID:23274516 PMID:24792323 PMID:24933654 PMID:31715134

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

choline kinase alpha

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHKA mRNA

NCBI chr 1:210,506,069...210,554,753
Ensembl chr 1:210,506,056...210,554,752

G

cholinergic receptor, muscarinic 2

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CHRM2 mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM2 mRNA]

PMID:22129741 PMID:29253600

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

cholinergic receptor, muscarinic 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM3 mRNA]

NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304

G

cholinergic receptor, muscarinic 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CHRM4 mRNA]

NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:98,348,650...98,358,771

G

component of inhibitor of nuclear factor kappa B kinase complex

decreases activity

ISO

Acetylcysteine results in decreased activity of CHUK protein

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

cytokine inducible SH2-containing protein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

creatine kinase B

multiple interactions

EXP

[Deferoxamine co-treated with Acetylcysteine] inhibits the reaction [Acetaminophen results in decreased activity of CKB protein]; [Deferoxamine co-treated with Acetylcysteine] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CKB protein]

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions
decreases secretion

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CKM mRNA]
Acetylcysteine results in decreased secretion of CKM protein

PMID:9689591 PMID:21912612

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

claudin 1

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLDN1 mRNA; Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN1 mRNA]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CLDN1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of CLDN1 protein]

PMID:22129741 PMID:28115242 PMID:29235125 PMID:32687961 PMID:33485121 More...

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 4

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN4 mRNA]

PMID:23816505 PMID:33485121

NCBI chr12:27,388,160...27,389,958
Ensembl chr12:27,387,981...27,389,958

G

claudin 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of and affects the localization of CLDN5 protein]; Acetylcysteine inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of CLDN5 protein]

PMID:28115242 PMID:34391839

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

C-type lectin domain containing 9A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CLEC9A mRNA

NCBI chr 4:164,546,323...164,561,380
Ensembl chr 4:164,546,311...164,561,380

G

CDC-like kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of CLK1 mRNA]

NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:67,441,952...67,451,187

G

clusterin

multiple interactions

ISO

Acetylcysteine promotes the reaction [Chlorine results in increased expression of CLU protein]

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

chymase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CMA1 mRNA

NCBI chr15:33,387,351...33,390,133
Ensembl chr15:33,387,351...33,390,133

G

ciliary neurotrophic factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CNTF protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]

PMID:16896058 PMID:26138014

NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488

G

collagen type XVIII alpha 1 chain

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]

NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,473,645...11,582,112

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

ISO
EXP

Acetylcysteine results in decreased expression of COL1A1 mRNA
Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA]; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of COL1A1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 protein]
Acetylcysteine results in decreased expression of COL1A1 mRNA; Acetylcysteine results in decreased expression of COL1A1 protein

PMID:11710721 PMID:17602960 PMID:32659284 PMID:34547296 PMID:36493885 More...

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

decreases expression

ISO

Acetylcysteine results in decreased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type IV alpha 1 chain

decreases expression

ISO

Acetylcysteine results in decreased expression of COL4A1 mRNA

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

collagen like tail subunit of asymmetric acetylcholinesterase

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of COLQ mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of COLQ mRNA]

NCBI chr16:6,738,251...6,830,492
Ensembl chr16:6,738,251...6,793,501

G

COPI coat complex subunit gamma 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Paraquat results in increased methylation of COPG1 mRNA]

NCBI chr 4:121,923,644...121,949,819
Ensembl chr 4:121,923,873...121,949,812

G

cytochrome c oxidase subunit 4i1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of COX4I1 mRNA]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of COX4I1 mRNA]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of COX4I1 protein]

PMID:33161305 PMID:35403558 PMID:36493885

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

carboxypeptidase E

decreases expression

ISO

Acetylcysteine results in decreased expression of CPE mRNA

NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524

G

complexin 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPLX1 mRNA

NCBI chr14:1,329,073...1,360,781
Ensembl chr14:1,329,032...1,360,769

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP

[Acetylcysteine co-treated with Dietary Fats] results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

carnitine palmitoyltransferase 1B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CPT1B mRNA

NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036

G

CASP2 and RIPK1 domain containing adaptor with death domain

decreases expression

ISO

Acetylcysteine results in decreased expression of CRADD mRNA

NCBI chr 7:31,827,131...31,839,796
Ensembl chr 7:31,685,622...31,874,512

G

carnitine O-acetyltransferase

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CRAT mRNA

NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099

G

cAMP responsive element binding protein 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of CREB1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein]
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]

PMID:18375950 PMID:32433928 PMID:36813253 PMID:38642822

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element modulator

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CREM mRNA]

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

cryptochrome circadian regulator 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CRY1 mRNA]

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822

G

crystallin, alpha B

multiple interactions

EXP

Acetylcysteine inhibits the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

crystallin, gamma A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CRYGA mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CRYGA mRNA]

NCBI chr 9:73,975,914...74,006,614
Ensembl chr 9:73,975,914...74,003,290

G

citrate synthase

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of CS mRNA]
Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of CS protein]]
Acetylcysteine promotes the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

PMID:21775390 PMID:27385396 PMID:36762617

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

colony stimulating factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CSF1 mRNA]

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 1 receptor

multiple interactions

ISO

[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806

G

colony stimulating factor 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased secretion of CSF2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein]

PMID:10645887 PMID:19460412 PMID:26138014 PMID:29753051

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

colony stimulating factor 3 receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of CSF3R mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of CSF3R mRNA]]

NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:143,583,213...143,602,411

G

cystatin C

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CST3 protein]

NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:156,790,079...156,793,937

G

catenin beta 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of CTNNB1 protein]; Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased phosphorylation of CTNNB1 protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [GSK3B protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of and results in increased activity of CTNNB1 protein]; Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of and affects the localization of CTNNB1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased cleavage of CTNNB1 protein]; Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of CTNNB1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]

PMID:16282376 PMID:19436114 PMID:24961358 PMID:24968063 PMID:28321046 More...

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

chymotrypsin C

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CTRC mRNA

NCBI chr 5:159,430,333...159,439,557
Ensembl chr 5:159,430,335...159,439,545

G

chymotrypsin-like

multiple interactions

ISO

Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein]

NCBI chr19:50,737,078...50,740,659
Ensembl chr19:50,737,079...50,738,979

G

cathepsin B

multiple interactions

ISO

[Acetylcysteine co-treated with 1,12-benzoperylene] results in increased expression of CTSB protein; [Acetylcysteine co-treated with Chloroquine] results in increased expression of CTSB protein; Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased secretion of CTSB protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CTSB mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of CTSB mRNA]

PMID:29307831 PMID:31319114 PMID:38408632 PMID:39701484

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

ISO

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin K

multiple interactions

ISO

[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of CTSK mRNA]]; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CTSK protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of CTSK mRNA]

PMID:30742845 PMID:38896780 PMID:38971422

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

cathepsin L

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Berberine results in decreased cleavage of CTSL protein]

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cut-like homeobox 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CUX2 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CUX2 mRNA]

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:40,149,292...40,366,528

G

C-X-C motif chemokine ligand 1

decreases expression
multiple interactions

ISO
EXP

Acetylcysteine results in decreased expression of CXCL1 protein
Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of CXCL1 protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]

PMID:17395010 PMID:18257742

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 12

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of CXCL12 protein]
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CXCL12 mRNA]

PMID:26138014 PMID:35123994

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of CXCL2 mRNA]; Acetylcysteine inhibits the reaction [Vanadates results in increased expression of CXCL2 mRNA]
Acetylcysteine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CXCL2 protein]

PMID:10718115 PMID:16919916 PMID:19350554 PMID:21507677

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of CXCL1 protein
Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]

PMID:17395010 PMID:24316229 PMID:28555929

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 6

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of CXCL6 protein]

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

cytochrome b-245 alpha chain

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome b-245 beta chain

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of CYBB protein]

PMID:21195169 PMID:29087013

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome c, somatic

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [dimethoxycurcumin affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [naringin results in decreased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein affects the localization of CYCS protein]
Acetylcysteine results in decreased expression of CYCS protein
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYCS mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds affects the localization of CYCS protein]

PMID:18483861 PMID:19536524 PMID:19954742 PMID:21145380 PMID:21221209 More...

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome c, testis

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Estradiol results in increased expression of CYCT protein]

NCBI chr 3:81,697,333...81,704,401
Ensembl chr 3:81,697,333...81,700,514

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP11A1 protein]

PMID:26769589 PMID:29567110 PMID:31160972

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B1 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B1 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B1 mRNA]

NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of CYP11B2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of CYP11B2 mRNA]

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of CYP17A1 protein]

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CYP19A1 mRNA]; Acetylcysteine inhibits the reaction [bisphenol S results in decreased expression of CYP19A1 mRNA]
Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP19A1 mRNA]

PMID:31160972 PMID:37944787

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO
EXP

[Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] which results in decreased expression of NQO1 mRNA; Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [1-(4-chlorophenyl)-benzo-2,5-quinone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of CYP1A1 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]
Acetylcysteine results in increased expression of CYP1A1 protein
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of CYP1A1 mRNA; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
[Acetylcysteine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Acetylcysteine affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [beta-Naphthoflavone results in decreased activity of CYP1A1 protein]; Acetylcysteine inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Acetylcysteine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]

PMID:15044633 PMID:15621696 PMID:16274885 PMID:19033395 PMID:20801209 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP
ISO

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP1A2 mRNA]
[CYP1A2 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite; Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP1A2 mRNA]

PMID:21424224 PMID:22129741 PMID:23159886 PMID:27989148 PMID:34200939

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

ISO
EXP

Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP1B1 mRNA]

PMID:21703343 PMID:22129741

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 26, subfamily C, polypeptide 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP26C1 mRNA

NCBI chr 1:244,870,412...244,881,610
Ensembl chr 1:244,871,612...244,880,297

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

EXP

Acetylcysteine promotes the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]

PMID:11353799 PMID:14722249

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

ISO

[CYP2C19 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite; Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2C19 mRNA]

PMID:27989148 PMID:34200939

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP
ISO

[Acetylcysteine co-treated with Zinc co-treated with Selenium] inhibits the reaction [dimethyl mercury results in decreased expression of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of CYP2E1 mRNA]; Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of CYP2E1 mRNA]
Acetylcysteine inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP2E1 mRNA]
Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]

PMID:21424224 PMID:23159886 PMID:26332274 PMID:30423402 PMID:34200939 More...

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP3A4 mRNA]

PMID:25451576 PMID:27989148 PMID:34200939

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CYP4A1 mRNA; Acetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA]

PMID:19647067 PMID:22129741

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 51

multiple interactions

ISO

Acetylcysteine inhibits the reaction [flutriafol results in increased expression of CYP51A1 mRNA]

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

death associated protein kinase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

DDHD domain containing 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DDHD1 mRNA

NCBI chr15:21,304,053...21,370,608
Ensembl chr15:21,303,826...21,370,608

G

DNA-damage inducible transcript 3

increases expression
decreases expression
multiple interactions

ISO
EXP

Acetylcysteine results in increased expression of DDIT3 mRNA; Acetylcysteine results in increased expression of DDIT3 protein
Acetylcysteine results in decreased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of DDIT3 protein]
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]; [ginsenoside Rg3 co-treated with Acetylcysteine] inhibits the reaction [Glucose results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3]; Acetylcysteine inhibits the reaction [celastrol methyl ester results in increased phosphorylation of DDIT3 protein]; Acetylcysteine inhibits the reaction [CSC-3436 results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [discretamine results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [hesperetin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [shogaol results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DDIT3 protein]]
Acetylcysteine inhibits the reaction [[bisphenol A co-treated with Dietary Fats co-treated with Cholesterol co-treated with Cholic Acid] results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Arecoline results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased expression of DDIT3 protein]]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of DDIT3 mRNA]

PMID:16084531 PMID:17171638 PMID:18077580 PMID:18384088 PMID:19722195 More...

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

defensin beta 105A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB12 mRNA

NCBI chr16:76,838,686...76,841,113
Ensembl chr16:76,838,664...76,841,113

G

defensin beta 18

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB18 mRNA

NCBI chr 9:28,348,776...28,349,793
Ensembl chr 9:28,348,776...28,349,793

G

defensin beta 49

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DEFB49 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DEFB49 mRNA]

NCBI chr 9:28,329,236...28,333,898
Ensembl chr 9:28,329,236...28,333,999

G

defensin beta 5

decreases expression

ISO

Acetylcysteine results in decreased expression of DEFB4A mRNA

NCBI chr16:77,315,424...77,317,828
Ensembl chr16:77,315,424...77,317,828

G

diacylglycerol O-acyltransferase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of DGAT2 mRNA]; Acetylcysteine inhibits the reaction [Valproic Acid results in increased expression of DGAT2 protein]

NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:162,866,237...162,896,566

G

dihydrofolate reductase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of DHFR mRNA]

NCBI chr 2:25,320,895...25,346,004

G

desert hedgehog signaling molecule

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DHH mRNA

NCBI chr 7:131,929,857...131,935,352
Ensembl chr 7:131,929,857...131,935,352

G

diablo, IAP-binding mitochondrial protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of DIABLO protein]

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265

G

iodothyronine deiodinase 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

iodothyronine deiodinase 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]

NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:135,107,074...135,107,985

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

discs large MAGUK scaffold protein 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein]

PMID:27624276 PMID:28153600

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839

G

doublesex and mab-3 related transcription factor 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DMRT1 mRNA

NCBI chr 1:232,569,179...232,667,646
Ensembl chr 1:232,569,072...232,668,370

G

dynein, axonemal, heavy chain 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of DNAH3 mRNA]

NCBI chr 1:183,738,013...183,910,831
Ensembl chr 1:183,738,013...183,910,432

G

dynein, axonemal, intermediate chain 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DNAI1 mRNA

NCBI chr 5:61,526,079...61,596,806
Ensembl chr 5:61,525,999...61,596,810

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA]

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB4 mRNA]

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

ISO

Acetylcysteine results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

dynamin 1-like

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 affects the reaction [DNM1L protein binds to DNM1L protein binds to DNM1L protein binds to DNM1L protein]]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of DNM1L protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]
Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of and results in increased phosphorylation of DNM1L protein]
Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate affects the localization of DNM1L protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased expression of and affects the phosphorylation of DNM1L protein]

PMID:20307494 PMID:30641872 PMID:31408635 PMID:37084995 PMID:37499777

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

DNA methyltransferase 1

multiple interactions

ISO

[Acetylcysteine co-treated with Hydrogen Peroxide] results in increased expression of DNMT1 mRNA; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased methylation of DNMT1 promoter; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [DNMT1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of DNMT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 protein]

PMID:29854080 PMID:31150806 PMID:31551408

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of DNMT3B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]

PMID:26942697 PMID:31551408

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

desmoglein 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of DSG1B mRNA

NCBI chr18:11,948,098...11,980,455
Ensembl chr18:11,949,488...11,980,451

G

desmoplakin

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]

NCBI chr17:26,829,153...26,877,419
Ensembl chr17:26,829,153...26,877,121

G

dentin sialophosphoprotein

increases expression

ISO

Acetylcysteine results in increased expression of DSPP mRNA

NCBI chr14:5,870,232...5,876,339
Ensembl chr14:5,870,232...5,876,339

G

dual specificity phosphatase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of DUSP1 protein]

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 4

increases expression

ISO

Acetylcysteine results in increased expression of DUSP4 mRNA

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:64,079,893...64,093,700

G

deoxyuridine triphosphatase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [beta-hydroxyisovalerylshikonin results in decreased phosphorylation of and results in decreased activity of DUT protein]

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:132,952,394...132,964,956

G

E2F transcription factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of E2F1 protein]

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

endothelin 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein]

PMID:14623829 PMID:16261333 PMID:21765237

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

EF-hand calcium binding domain 3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFCAB3 mRNA

NCBI chr10:90,084,495...90,577,145
Ensembl chr10:90,084,397...90,577,144

G

ephrin A1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EFNA1 mRNA

NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:176,979,434...176,988,726

G

ephrin B2

decreases expression

ISO

Acetylcysteine results in decreased expression of EFNB2 mRNA

NCBI chr16:87,485,215...87,529,224
Ensembl chr16:87,485,198...87,529,208

G

epidermal growth factor

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of EGF protein]; Acetylcysteine inhibits the reaction [cyadox results in increased expression of EGF]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA mRNA]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA protein]
Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]; Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of Peroxides]

PMID:11158190 PMID:11214823 PMID:26138014 PMID:30265530 PMID:32092105

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGFR mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of EGFR protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:10640773 PMID:14660655 PMID:15520183 PMID:15849355 PMID:16261333 More...

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of EGLN1 mRNA]

NCBI chr19:69,765,276...69,804,681

G

early growth response 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGR1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of EGR1 mRNA]
Acetylcysteine inhibits the reaction [platycodin D results in increased expression of EGR1 mRNA]

PMID:10625299 PMID:18804340 PMID:19010381

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

early growth response 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

EI24, autophagy associated transmembrane protein

multiple interactions

ISO

Acetylcysteine promotes the reaction [Tobacco Smoke Pollution results in increased expression of EI24 mRNA]

NCBI chr 8:44,683,138...44,699,502
Ensembl chr 8:44,683,144...44,695,214

G

eukaryotic translation initiation factor 2A

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [salubrinal promotes the reaction [Cisplatin results in increased phosphorylation of EIF2A protein]]
Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [bisphenol S results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [celastrol methyl ester results in increased phosphorylation of EIF2A protein]
Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [Cadmium results in decreased phosphorylation of EIF2A protein]

PMID:21616140 PMID:25451595 PMID:27658547 PMID:29373603 PMID:37944787 More...

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
decreases expression

ISO
EXP

[Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EIF2AK3 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [bisphenol S results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [pendulone results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]
Acetylcysteine results in decreased expression of EIF2AK3 protein modified form
Acetylcysteine inhibits the reaction [Arecoline results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of EIF2AK3 protein]

PMID:19722195 PMID:25341683 PMID:25451595 PMID:27484784 PMID:27784618 More...

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [chrysophanic acid results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of EIF2S1 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2S1 protein modified form]
Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2S1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of EIF2S1 protein]

PMID:15788408 PMID:16324875 PMID:21911445 PMID:24291486 PMID:25568320 More...

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased phosphorylation of EIF4EBP1 protein]

PMID:21195169 PMID:24299490 PMID:26804764 PMID:30661989 PMID:36709824

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

elastin microfibril interfacer 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EMILIN2 mRNA

NCBI chr 9:118,607,312...118,667,087
Ensembl chr 9:118,606,891...118,666,957

G

endonuclease G

multiple interactions

ISO

[Glucose deficiency co-treated with Acetylcysteine] affects the localization of ENDOG protein; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]

PMID:17309078 PMID:18034189

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

endoglin

increases expression

ISO

Acetylcysteine results in increased expression of ENG mRNA; Acetylcysteine results in increased expression of ENG protein

NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:36,326,202...36,370,933

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]

NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ENPP7 mRNA

NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760

G

endosomal transmembrane epsin interactor 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ENTREP1 mRNA

NCBI chr 1:231,018,987...231,073,474
Ensembl chr 1:231,018,987...231,102,708

G

E1A binding protein p300

multiple interactions

ISO

Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

endothelial PAS domain protein 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

erythrocyte membrane protein band 4.1

multiple interactions

EXP

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in decreased expression of EPB41 protein]

NCBI chr 5:149,394,080...149,548,178
Ensembl chr 5:149,394,096...149,543,540

G

Eph receptor B1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPHB1 mRNA

NCBI chr 8:111,386,432...111,823,759
Ensembl chr 8:111,386,432...111,823,759

G

EGFR pathway substrate 8, signaling adaptor

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of EPS8 mRNA

NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:172,119,497...172,218,160

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of ERCC1 mRNA]

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:88,118,891...88,139,120

G

ERCC excision repair 8, CSA ubiquitin ligase complex subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [dicrotophos results in decreased expression of ERCC8 protein]

NCBI chr 2:41,380,901...41,418,294
Ensembl chr 2:41,380,901...41,418,294

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
decreases phosphorylation

EXP
ISO

Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased phosphorylation of ERN1 protein]
Acetylcysteine results in decreased phosphorylation of ERN1 protein
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [Arecoline results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ERN1 protein modified form]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of ERN1 protein]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]

PMID:21198628 PMID:24394546 PMID:25451595 PMID:27784618 PMID:29373603 More...

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of ESR1 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA]
Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of ESR1 protein]
Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein]

PMID:18829485 PMID:26149760 PMID:32402895 PMID:39260547

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR2 mRNA]
Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ESR2 mRNA]

PMID:18829485 PMID:31160972

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

estrogen related receptor, alpha

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ESRRA protein]

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

ETS proto-oncogene 1, transcription factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ETS1 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ETS1 mRNA]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ETS1 mRNA]

NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] inhibits the reaction [EZH2 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of EZH2 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein]

PMID:24582688 PMID:31551408

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

coagulation factor XIII A1 chain

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of F13A1 mRNA

NCBI chr17:28,021,197...28,197,960
Ensembl chr17:28,020,845...28,197,948

G

coagulation factor III, tissue factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

Fas associated via death domain

multiple interactions

EXP
ISO

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite results in increased expression of FADD protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of FADD mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in decreased expression of FADD protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of FADD mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in decreased expression of FADD protein]]

PMID:20946910 PMID:35833596

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fatty acid desaturase 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

family with sequence similarity 114, member A1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A1 mRNA

NCBI chr14:43,629,349...43,699,800
Ensembl chr14:43,629,375...43,699,800

G

family with sequence similarity 114, member A2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A2 mRNA

NCBI chr10:42,162,295...42,197,307
Ensembl chr10:42,162,295...42,197,257

G

family with sequence similarity 13, member A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM13A mRNA

NCBI chr 4:89,386,685...89,485,940
Ensembl chr 4:89,388,569...89,485,988

G

family with sequence similarity 186 member A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM186A mRNA

NCBI chr 7:132,922,410...132,981,466

G

fatty acyl CoA reductase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAR1 mRNA

NCBI chr 1:177,078,973...177,140,363
Ensembl chr 1:177,079,150...177,161,696

G

Fas cell surface death receptor

multiple interactions
increases expression

EXP
ISO

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of FAS mRNA]
Acetylcysteine results in increased expression of FAS mRNA
Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of FAS protein]; Acetylcysteine inhibits the reaction [[Heterocyclic Compounds binds to Thiazoles] which results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased expression of FAS protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of FAS protein]

PMID:9227460 PMID:15382040 PMID:16169029 PMID:19014919 PMID:19477266 More...

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
increases expression

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of FASLG mRNA; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with FASLG protein] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased expression of FASLG protein]
Acetylcysteine results in increased expression of FASLG mRNA
[Atorvastatin co-treated with Acetylcysteine] inhibits the reaction [sodium arsenite results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of FASLG mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of FASLG protein]
Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of FASLG protein]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of FASLG protein]

PMID:11864783 PMID:17574045 PMID:19644561 PMID:19720122 PMID:19760616 More...

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box protein 32

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Indican results in increased expression of FBXO32 protein]

NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:91,620,925...91,654,491

G

flap structure-specific endonuclease 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of FEN1 mRNA]

NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:216,269,163...216,275,016

G

fer-1-like family member 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FER1L5 mRNA

NCBI chr 9:46,101,798...46,156,483
Ensembl chr 9:46,103,760...46,156,479

G

fibroblast growth factor 12

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF12 mRNA

NCBI chr11:85,501,947...86,069,543
Ensembl chr11:85,501,936...86,069,543

G

fibroblast growth factor 2

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of FGF2 mRNA
Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]

PMID:16084531 PMID:19176594

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor 21

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]
Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of FGF21 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased secretion of FGF21 protein]

PMID:22129741 PMID:22917661

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

fibroblast growth factor 6

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FGF6 protein]

NCBI chr 4:161,541,089...161,549,624
Ensembl chr 4:161,541,089...161,553,521

G

fibroblast growth factor 7

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FGF7 protein]

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:133,734,673...133,786,328

G

fragile histidine triad diadenosine triphosphatase

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein]

NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621

G

filamin A interacting protein 1-like

decreases expression

ISO

Acetylcysteine results in decreased expression of FILIP1L mRNA

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:56,410,582...56,646,402

G

fission, mitochondrial 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of FIS1 protein]
Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein]

PMID:37084995 PMID:37499777

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

FKBP prolyl isomerase 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA]

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

filaggrin

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA

NCBI chr 2:181,583,801...181,596,464
Ensembl chr 2:181,583,808...181,595,968

G

filamin A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:157,159,051...157,182,343

G

Fms related receptor tyrosine kinase 1

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of FLT1 protein
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of FLT1 mRNA]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of FLT1 mRNA]

PMID:17992120 PMID:29408318

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

Fms related receptor tyrosine kinase 3 ligand

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of FLT3LG protein]

NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:104,749,983...104,757,038

G

fragile X messenger ribonucleoprotein 1

multiple interactions

ISO

Acetylcysteine promotes the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675

G

fibronectin 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Glucose results in increased expression of FN1 protein]
Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP10 protein]; Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]

PMID:16632126 PMID:17395008 PMID:22245600 PMID:22648416

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases activity

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased activity of FOS protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of FOS]
Acetylcysteine results in decreased activity of FOS protein
Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in decreased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of and results in increased phosphorylation of FOS protein]; Acetylcysteine promotes the reaction [bis(maltolato)oxovanadium(IV) results in decreased activity of [FOS protein binds to JUN protein]]
Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of FOS mRNA]

PMID:7743507 PMID:8825185 PMID:8853906 PMID:9043100 PMID:9525474 More...

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOSL1 mRNA]

PMID:15520183 PMID:19010381

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

forkhead box D2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FOXD2 mRNA

NCBI chr 5:133,664,760...133,667,483
Ensembl chr 5:133,664,760...133,667,483

G

forkhead box D4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FOXD4 mRNA

NCBI chr 1:231,983,872...231,985,565

G

forkhead box M1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Thiostrepton results in decreased expression of FOXM1 protein]

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172

G

forkhead box O1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of FOXO1 protein modified form]; Acetylcysteine inhibits the reaction [Glucose affects the localization of FOXO1 protein]

PMID:23765110 PMID:33450223

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

forkhead box O3

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]
Acetylcysteine inhibits the reaction [deoxynivalenol affects the localization of and results in increased activity of FOXO3A protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of FOXO3 protein]
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of FOXO3 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of FOXO3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of FOXO3 protein]

PMID:20883752 PMID:23159718 PMID:25471227 PMID:30104959 PMID:30169763 More...

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

forkhead box P3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 protein]

NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

ferritin heavy chain 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Rotenone results in increased expression of FTH1 mRNA]
Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of FTH1 protein]

PMID:18325346 PMID:32687844

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [arsenite results in increased expression of FTL1 protein]

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

FTO, alpha-ketoglutarate dependent dioxygenase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of FTO mRNA]
Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of FTO mRNA]

PMID:31004932 PMID:34425375

NCBI chr19:31,456,749...31,865,011
Ensembl chr19:31,522,293...31,864,957

G

frataxin

affects response to substance
multiple interactions

ISO

Acetylcysteine affects the susceptibility to FXN protein mutant form
Acetylcysteine affects the reaction [Ethanol affects the expression of FXN protein]

PMID:16120311 PMID:33017621

NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:231,300,150...231,323,989

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of FYN protein]
Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]

PMID:12902192 PMID:20850416

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

multiple interactions
increases activity

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of G6PD mRNA]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]
Acetylcysteine results in increased activity of G6PD protein

PMID:3099627 PMID:12717738 PMID:15225644

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
decreases expression
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Formaldehyde results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [rhododendrol results in increased expression of GADD45A mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of GADD45A mRNA]
Acetylcysteine results in decreased expression of GADD45A mRNA
Acetylcysteine results in increased expression of GADD45A mRNA
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45A mRNA; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]

PMID:18849615 PMID:22129741 PMID:24291486 PMID:26332274 PMID:26867644

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest and DNA-damage-inducible, gamma

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GADD45G mRNA
Acetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein]

PMID:22129741 PMID:23313378

NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,528,610...13,530,369

G

polypeptide N-acetylgalactosaminyltransferase-like 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GALNTL5 mRNA

NCBI chr 4:10,607,260...10,657,181
Ensembl chr 4:10,607,260...10,656,953

G

growth associated protein 43

multiple interactions

EXP

Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]

NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

EXP

Acetylcysteine results in decreased expression of GAPDH mRNA
Acetylcysteine inhibits the reaction [arsenite results in decreased expression of GAPDH protein]

PMID:11108245 PMID:15175009

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

GATA binding protein 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of GATA1 mRNA]

NCBI chr X:17,193,291...17,209,462
Ensembl chr X:17,201,633...17,209,459

G

guanylate binding protein 1

decreases expression

ISO

Acetylcysteine results in decreased expression of GBP1 mRNA

NCBI chr 2:234,071,366...234,106,012
Ensembl chr 2:234,190,708...234,206,802
Ensembl chr 2:234,190,708...234,206,802

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of GCLC protein]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of GCLC mRNA]
Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of GCLC protein]
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of GCLC mRNA]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]

PMID:11820781 PMID:11909699 PMID:16631525 PMID:17540521 PMID:17980396 More...

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
affects response to substance

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GCLM mRNA]; Acetylcysteine inhibits the reaction [elesclomol results in increased expression of GCLM mRNA]
GCLM protein affects the susceptibility to Acetylcysteine
[Acetylcysteine co-treated with Acetaminophen] results in decreased expression of GCLM mRNA; Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLM mRNA]

PMID:17584759 PMID:18723479 PMID:19328227 PMID:19350554 PMID:37598316

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

growth differentiation factor 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GDF1 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of GDF1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GDF1 protein]

NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,131,276...19,146,480

G

growth differentiation factor 15

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of GDF15 mRNA]

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glial cell derived neurotrophic factor

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GDNF mRNA
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GDNF protein]

PMID:22129741 PMID:26138014

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

glial fibrillary acidic protein

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]
Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of GFAP protein]

PMID:28499986 PMID:31173782

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gamma-glutamyltransferase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GGT1 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased secretion of GGT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]; Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]; Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of GGT1 protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of GGT1 protein]]

PMID:12030384 PMID:22129741 PMID:24485406 PMID:24634002 PMID:27387968

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

gap junction protein, alpha 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of GJA1 protein]
[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA; [Fulvestrant co-treated with U 0126] affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]; Acetylcysteine inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of GJA1 protein]; bisphenol A affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]; Fulvestrant affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]; U 0126 affects the reaction [[Acetylcysteine co-treated with ascorbate-2-phosphate] affects the expression of GJA1 mRNA]

PMID:32610363 PMID:34906888 PMID:37692924

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

gap junction protein, alpha 4

decreases expression

ISO

Acetylcysteine results in decreased expression of GJA4 mRNA

NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:144,914,147...144,921,216

G

gap junction protein, beta 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of GJB1 mRNA]

NCBI chr X:70,541,845...70,549,776
Ensembl chr X:70,541,862...70,549,843

G

glycerol kinase

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]

NCBI chr X:54,106,708...54,189,940
Ensembl chr X:54,112,214...54,196,701

G

gastrokine 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GKN2 mRNA

NCBI chr 4:121,335,642...121,381,680
Ensembl chr 4:121,375,594...121,381,678

G

galactosidase, beta 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of GLB1 protein]; Acetylcysteine inhibits the reaction [lopinavir-ritonavir drug combination results in increased activity of GLB1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]

PMID:20884875 PMID:31551408

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

glucocorticoid induced 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GLCCI1 mRNA

NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802

G

glucagon-like peptide 1 receptor

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]

NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,973,352...9,011,654

G

glutaredoxin

affects response to substance

ISO

GLRX protein affects the susceptibility to Acetylcysteine

NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:7,073,759...7,083,543

G

glutamate dehydrogenase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of GLUD1 mRNA]

NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210

G

G protein subunit alpha i2

multiple interactions

ISO
EXP

Acetylcysteine affects the reaction [IER3 protein affects the expression of GNAI2 mRNA]
Acetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein]

PMID:18441196 PMID:20713914

NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622

G

G protein subunit alpha i3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]

NCBI chr 2:198,430,920...198,468,874

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glycoprotein Ib platelet subunit alpha

multiple interactions

ISO

Acetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]

NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,829,832...55,854,560

G

glycoprotein 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GP2 mRNA

NCBI chr 1:183,228,395...183,243,954
Ensembl chr 1:183,228,395...183,243,954

G

G protein-coupled bile acid receptor 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPBAR1 mRNA

NCBI chr 9:83,309,895...83,312,397
Ensembl chr 9:83,311,246...83,315,608

G

glypican 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPC5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPC5 mRNA]

NCBI chr15:98,614,499...100,051,285
Ensembl chr15:98,646,340...100,051,514

G

G protein-coupled receptor 153

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR153 mRNA

NCBI chr 5:168,064,134...168,075,697
Ensembl chr 5:168,064,311...168,074,532

G

G protein-coupled receptor 20

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR20 mRNA

NCBI chr 7:107,490,419...107,500,993
Ensembl chr 7:107,490,713...107,500,966

G

G protein-coupled receptor 55

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR55 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA]

NCBI chr 9:94,037,748...94,081,426
Ensembl chr 9:94,036,162...94,088,707

G

glutamic--pyruvic transaminase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]; IL22 protein promotes the reaction [Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]
[Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of GPT protein]; Acetylcysteine inhibits the reaction [Cyclosporine results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Glyphosate results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]]

PMID:17461432 PMID:20688495 PMID:20804811 PMID:23375450 PMID:24485406 More...

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of GPX1 protein]
Acetylcysteine results in increased expression of GPX1 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of GPX1 protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]; Acetylcysteine inhibits the reaction [raspberry ketone results in decreased expression of GPX1 protein]; Acetylcysteine inhibits the reaction [rhododendrol results in decreased expression of GPX1 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of GPX1 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of GPX1 protein]

PMID:25341683 PMID:26867644 PMID:30037311 PMID:30104959 PMID:35112789 More...

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA]

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of GPX4 mRNA]

PMID:12208374 PMID:38097005

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Pilocarpine results in increased expression of GRIN2B protein]

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate metabotropic receptor 2

increases activity

ISO

Acetylcysteine results in increased activity of GRM2 protein

NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857

G

glutamate metabotropic receptor 3

increases activity

ISO

Acetylcysteine results in increased activity of GRM3 protein

NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764

G

glutamate metabotropic receptor 5

increases activity

ISO

Acetylcysteine results in increased activity of GRM5 protein

NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649

G

gasdermin D

multiple interactions
increases expression

ISO
EXP

Acetylcysteine affects the reaction [diallyl trisulfide results in increased expression of and results in increased cleavage of GSDMD protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of GSDMD protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased expression of GSDMD protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased cleavage of GSDMD protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased cleavage of GSDMD protein]]
Acetylcysteine results in increased expression of GSDMD protein
Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of GSDMD protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of and results in increased cleavage of GSDMD protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of GSDMD mRNA]
Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of GSDMD mRNA]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of GSDMD protein]; Acetylcysteine inhibits the reaction [Atrazine results in increased expression of GSDMD protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of and results in decreased expression of GSDMD protein]

PMID:30378427 PMID:34791735 PMID:36347317 PMID:36354081 PMID:36646296 More...

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

gasdermin E

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of GSDME protein]

NCBI chr 4:80,590,344...80,651,943
Ensembl chr 4:80,588,614...80,641,525

G

glycogen synthase kinase 3 beta

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of GSK3B protein]
[Acetylcysteine co-treated with Chlorpyrifos] results in increased activity of GSK3B protein; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [GSK3B protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of GSK3B protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]

PMID:18569013 PMID:19126599 PMID:24968063 PMID:25246272 PMID:27658547 More...

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of GSR mRNA]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in decreased expression of GSR mRNA]
Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]
[Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Acetylcysteine co-treated with Paraquat] results in increased activity of GSR protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide inhibits the reaction [GSR protein results in increased oxidation of NADP]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]; Acetylcysteine inhibits the reaction [Dimethylnitrosamine results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [Paraquat results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of GSR protein]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [EUK-134 results in decreased activity of GSR protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]]

PMID:16631525 PMID:19840221 PMID:21114986 PMID:23159886 PMID:24634002 More...

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase alpha 4

multiple interactions

EXP

[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]

PMID:23159886 PMID:25724285 PMID:30639957

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase alpha 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTA5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA]

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [alpha-methylepinine results in increased expression of GSTM1 mRNA]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM1 mRNA

PMID:21871945 PMID:22129741

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase omega 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTO2 mRNA]

NCBI chr 1:256,673,376...256,695,154
Ensembl chr 1:256,673,274...256,695,146

G

glutathione S-transferase pi 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTP1 mRNA]
Acetylcysteine inhibits the reaction [flutriafol results in increased expression of GSTP1 mRNA]

PMID:22129741 PMID:34200939

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

GULP PTB domain containing engulfment adaptor 1

decreases expression

ISO

Acetylcysteine results in decreased expression of GULP1 mRNA

NCBI chr 9:54,114,823...54,391,058
Ensembl chr 9:54,114,731...54,397,452

G

glycophorin A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]

NCBI chr19:44,354,669...44,370,304
Ensembl chr19:44,354,706...44,370,291

G

H2A.X variant histone

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl)imidazole results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [captax results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [chloropicrin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [Crizotinib results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [eprenetapopt results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [gingerenone A results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [LAQ824 results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [Plant Extracts results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [tomentosin results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein]
Acetylcysteine results in increased expression of H2AX protein
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein]; Acetylcysteine inhibits the reaction [aristolochic acid I results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [yttrium chloride results in increased phosphorylation of H2AX protein]
Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of H2AX mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein]

PMID:15173094 PMID:15489221 PMID:18852132 PMID:19409983 PMID:21135414 More...

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hyaluronan synthase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]

NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:90,002,929...90,018,535

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein]
Acetylcysteine inhibits the reaction [Antimony results in increased expression of HAVCR1 protein]

PMID:35020164 PMID:38097005

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

HCLS1 associated protein X-1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]

NCBI chr 2:177,731,918...177,735,670
Ensembl chr 2:177,731,921...177,735,390

G

heparin-binding EGF-like growth factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,380,337...28,390,220

G

HECT domain E3 ubiquitin protein ligase 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Ethanol results in increased expression of HECTD4 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of HECTD4 mRNA]

PMID:31004932 PMID:35713687

NCBI chr12:40,800,232...40,991,584
Ensembl chr12:40,843,770...40,991,798

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of HERPUD1 mRNA
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HERPUD1 mRNA]

PMID:16084531 PMID:18723479

NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081

G

hes family bHLH transcription factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cypermethrin results in decreased expression of HES1 mRNA]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cypermethrin results in decreased expression of HEY2 mRNA]

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187

G

hepatocyte growth factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

Hedgehog-interacting protein

multiple interactions

EXP

[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of HHIP mRNA

NCBI chr19:44,768,038...44,856,878
Ensembl chr19:44,767,536...44,862,795

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]
Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Nickel analog results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]
1-(2-chloroethyl)-1-nitrosourea inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Fluorouracil affects the localization of HIF1A protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of HIF1A mRNA]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]

PMID:10866824 PMID:11641398 PMID:11886167 PMID:13679210 PMID:16530163 More...

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hexokinase 2

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of HK2 mRNA
Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein]]

PMID:16084531 PMID:36762617

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

hydroxymethylbilane synthase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of HMBS mRNA]

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

high mobility group AT-hook 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMGA2 protein]

NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:57,765,675...57,880,341

G

high mobility group box 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HMGB1 protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of HMGB1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]

PMID:26079697 PMID:30977640 PMID:36055550

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

high mobility group box 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:37,721,379...37,723,860

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

increases expression
multiple interactions
affects activity

ISO
EXP

Acetylcysteine results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [2,2'-dihydroxychalcone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide results in increased abundance of Peroxides] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid results in increased abundance of Peroxides] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [chromium trioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal results in increased expression of HMOX1]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Urea results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]; Polymyxin B inhibits the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]]
[Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine affects the reaction [alpha-pyrrolidinononanophenone analog affects the expression of HMOX1 protein]; Acetylcysteine affects the reaction [Chlorpyrifos affects the expression of HMOX1 protein]; Acetylcysteine affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [2-xylene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Benzene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [chloropicrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Coal Ash results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Silicon analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Silver analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Toluene results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; Acetylcysteine promotes the reaction [ochratoxin A results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of HMOX1 mRNA]
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; Acetylcysteine affects the reaction [Glucose affects the expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [oxophenylarsine results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of HMOX1 protein]
Acetylcysteine affects the activity of HMOX1 protein
Acetylcysteine results in increased expression of HMOX1 mRNA; Acetylcysteine results in increased expression of HMOX1 protein

PMID:7538129 PMID:9152014 PMID:9545559 PMID:9747510 PMID:10975858 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hepatocyte nuclear factor 4, gamma

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of HNF4G mRNA

NCBI chr 2:99,792,942...99,943,811
Ensembl chr 2:99,792,942...99,943,811

G

HRas proto-oncogene, GTPase

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]
Acetylcysteine inhibits the reaction [HRAS protein mutant form results in increased susceptibility to sodium arsenite]

PMID:15945272 PMID:25199681

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

heat shock factor binding protein 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Thioacetamide results in increased expression of HSBP1 protein]

NCBI chr19:64,309,703...64,314,035
Ensembl chr19:64,309,703...64,314,035

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA]

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of HSD17B3 mRNA]

PMID:26769589 PMID:29567110

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxysteroid (17-beta) dehydrogenase 8

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA]

NCBI chr20:4,828,571...4,830,635
Ensembl chr20:4,828,608...4,830,634

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD3B3 mRNA]

NCBI chr 2:188,826,756...188,832,734
Ensembl chr 2:188,826,110...188,904,981

G

heat shock transcription factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter affects the localization of HSF1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]]; Acetylcysteine inhibits the reaction [Vehicle Emissions affects the localization of HSF1 protein]

PMID:10403520 PMID:17922515 PMID:30309986

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 alpha family class A member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of HSP90AA1 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of HSP90AA1 protein]]

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 beta family member 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSP90B1 mRNA]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSP90B1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSP90B1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSP90B1 protein]
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSP90B1 protein]
Acetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]

PMID:21145380 PMID:21533816 PMID:21911445 PMID:25451595 PMID:25950987 More...

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1A mRNA]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HSPA1A protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of HSPA1A mRNA]
Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA1A protein]

PMID:12231548 PMID:16324719 PMID:18723479 PMID:36813253

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of HSPA1B mRNA]
Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPA1B protein]

PMID:15175009 PMID:18723479

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
decreases expression

ISO
EXP

Acetylcysteine results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of HSPA5 protein]
Acetylcysteine results in decreased expression of HSPA5 protein
4-phenylbutyric acid promotes the reaction [Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]; [Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [(4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [discretamine results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds affects the expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]]; Acetylcysteine inhibits the reaction [Resveratrol results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Acetylcysteine promotes the reaction [4-phenylbutyric acid inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HSPA5 protein]]
Acetylcysteine inhibits the reaction [Arecoline results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]

PMID:19722195 PMID:20493918 PMID:21145380 PMID:21198628 PMID:21533816 More...

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [arsenite results in increased expression of HSPB1 protein]

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of HSPD1 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of HSPD1 protein]]; Acetylcysteine inhibits the reaction [Chlorine results in increased expression of HSPD1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of HSPD1 mRNA]

PMID:32092105 PMID:35065218 PMID:37422542

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

HIV-1 Tat interactive protein 2

decreases expression

ISO

Acetylcysteine results in decreased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:108,605,811...108,624,815

G

intercellular adhesion molecule 1

affects expression
multiple interactions
decreases expression

ISO
EXP

Acetylcysteine affects the expression of ICAM1
Acetylcysteine affects the reaction [Dinitrochlorobenzene affects the expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Tin Fluorides results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein]
Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]
Acetylcysteine results in decreased expression of ICAM1 mRNA
Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased secretion of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]

PMID:10495789 PMID:10792388 PMID:11736926 PMID:17416599 PMID:17666914 More...

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 2

decreases expression

ISO

Acetylcysteine results in decreased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of IDH2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IDH2 protein]

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248

G

immediate early response 3

multiple interactions
affects response to substance

ISO

Acetylcysteine affects the reaction [IER3 protein affects the expression of GNAI2 mRNA]
IER3 protein affects the susceptibility to Acetylcysteine

NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,933,174...2,934,377

G

immediate early response 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IER5 mRNA]

NCBI chr13:69,820,450...69,822,542
Ensembl chr13:69,820,451...69,822,543

G

interferon-induced protein with tetratricopeptide repeats 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA]]

NCBI chr 1:241,515,735...241,521,799
Ensembl chr 1:241,515,709...241,521,798

G

interferon gamma

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IFNG protein]; Acetylcysteine inhibits the reaction [Eosine I Bluish results in increased expression of IFNG mRNA]; Acetylcysteine inhibits the reaction [Formaldehyde results in decreased expression of IFNG mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IFNG protein]
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IFNG protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

PMID:12847270 PMID:15004186 PMID:18849615 PMID:20431929 PMID:22440610 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon-related developmental regulator 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of IFRD1 mRNA]

NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131

G

insulin-like growth factor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGF1 protein]

PMID:17458902 PMID:26138014

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of IGF1R protein]

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor binding protein 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IGFBP1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IGFBP1 protein]

PMID:22129741 PMID:26138014

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of IGFBP2 protein]

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of IGFBP4 protein]

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases activity
multiple interactions

ISO

Acetylcysteine results in decreased activity of IKBKB protein
Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of IKBKB mRNA]
Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]

PMID:17395010 PMID:34310962 PMID:37458150

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO
EXP

[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 protein]; Acetylcysteine inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL10 protein]
Acetylcysteine inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Acetylcysteine promotes the reaction [Doxorubicin results in increased expression of IL10 mRNA]

PMID:11124598 PMID:20431929 PMID:20885979 PMID:21237301 PMID:21424515 More...

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 10 receptor subunit beta

decreases expression

ISO

Acetylcysteine results in decreased expression of IL10RB mRNA

NCBI chr11:44,132,471...44,154,062
Ensembl chr11:44,132,189...44,154,053

G

interleukin 12A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 13

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL13 protein]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 15

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL15 protein]

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 16

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL16 protein]

NCBI chr 1:147,026,852...147,127,177
Ensembl chr 1:147,027,097...147,127,023

G

interleukin 17A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL17A protein]; Acetylcysteine inhibits the reaction [Trichloroethylene results in increased expression of IL17A mRNA]

PMID:20431929 PMID:23993974

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 17D

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IL17D mRNA

NCBI chr15:35,786,898...35,804,391
Ensembl chr15:35,786,898...35,804,391

G

interleukin 18

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL18 protein]
Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IL18 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL18 protein]
Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL18 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL18 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased expression of IL18 protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased secretion of IL18 protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]]

PMID:27311643 PMID:30205151 PMID:34510229 PMID:34791735 PMID:35020164 More...

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 alpha

multiple interactions

ISO

[Acetylcysteine co-treated with IL1A protein] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of IL1A protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1A mRNA]; Acetylcysteine promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]
Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of IL1A protein]

PMID:7476933 PMID:24570342 PMID:26138014 PMID:28836394 PMID:37778984

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression
affects expression

EXP
ISO

Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL1B protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B protein]
Acetylcysteine results in increased expression of IL1B protein
[Acetylcysteine co-treated with Cobalt] results in decreased expression of IL1B protein; Acetylcysteine affects the reaction [diallyl trisulfide results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of IL1B protein modified form]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [2,4-decadienal results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Antimycin A co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [[Oligomycins co-treated with IL1B protein] results in increased expression of CXCL8 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of IL1B mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Cobalt results in increased expression of IL1B protein modified form]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; Acetylcysteine inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]; Acetylcysteine inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of IL1B mRNA]; Acetylcysteine promotes the reaction [titanium dioxide results in increased secretion of IL1B protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
[Acetylcysteine co-treated with raubasine] results in increased secretion of IL1B protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of IL1B mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of IL1B protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [bosutinib results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [ponatinib results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of IL1B mRNA]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased secretion of IL1B protein]
Acetylcysteine results in decreased expression of IL1B mRNA
Acetylcysteine affects the expression of IL1B protein

PMID:10541287 PMID:11970852 PMID:16014734 PMID:16214328 PMID:17071120 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of IL2 mRNA; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of IL2 protein]
Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of IL2 protein]

PMID:22429591 PMID:22910795 PMID:31173782

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 24

decreases activity

ISO

Acetylcysteine results in decreased activity of IL24 protein

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 27 receptor subunit alpha

decreases expression

ISO

Acetylcysteine results in decreased expression of IL27RA mRNA

NCBI chr19:41,014,730...41,026,740
Ensembl chr19:41,014,730...41,026,760

G

interleukin 2 receptor subunit alpha

multiple interactions

ISO

Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL3 protein]

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810

G

interleukin 33

multiple interactions

ISO

Acetylcysteine promotes the reaction [Soot results in increased expression of IL33 mRNA]

NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:237,115,572...237,150,901

G

interleukin 4

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL4 protein]
Acetylcysteine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of IL4 protein]

PMID:15569474 PMID:26138014 PMID:27634759

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 4 receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL4R mRNA]

NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:189,544,988...189,570,636

G

interleukin 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL5 protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL5 protein]

PMID:20431929 PMID:26138014

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions
decreases expression

EXP
ISO

Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of IL6 protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
Acetylcysteine results in decreased expression of IL6 mRNA
[Acetylcysteine co-treated with Ascorbic Acid] inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of IL6 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of IL6 protein]]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [calcium silicate results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Coal Ash results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [zinc chloride results in increased secretion of IL6 protein]
[Acetylcysteine co-treated with raubasine] results in increased secretion of IL6 protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of IL6 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of IL6 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL6 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]

PMID:9378980 PMID:9651185 PMID:10022265 PMID:11970852 PMID:16757516 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7 receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of IL7R mRNA alternative form]; IL7R mRNA alternative form promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN1A mRNA]]; IL7R mRNA alternative form promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of CDKN2A mRNA]]

NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027

G

insulin 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased expression of INS1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of PPARG protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in decreased secretion of INS1 protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Acetylcysteine inhibits the reaction [tributyltin results in increased secretion of INS1 protein]

PMID:15680273 PMID:16918248 PMID:20006636 PMID:21145380 PMID:23405080 More...

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein]; Acetylcysteine inhibits the reaction [tributyltin promotes the reaction [Glucose results in increased secretion of INS protein]]
Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2A protein]; Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [[INS co-treated with Acrylamide] results in increased phosphorylation of ERN1 protein]; Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]]

PMID:16505238 PMID:21888768 PMID:28180948 PMID:38604440

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

insulin induced gene 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of INSIG1 mRNA

NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778

G

insulin receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of INSR protein]
Acetylcysteine inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of INSR protein]

PMID:18569013 PMID:22917016

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

iron responsive element binding protein 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of IREB2 protein]

NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520

G

interferon regulatory factor 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRF1 mRNA

PMID:20525893 PMID:22129741

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

insulin receptor substrate 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of IRS1 protein]

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

insulin receptor substrate 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

insulin receptor substrate 3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of IRS3 mRNA

NCBI chr12:24,689,930...24,692,068
Ensembl chr12:24,689,909...24,692,068

G

integrin subunit alpha 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of ITGA2 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of ITGA2 mRNA]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of ITGA2 mRNA]

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

integrin subunit alpha 2b

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]

NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833

G

integrin subunit alpha M

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of ITGAM mRNA]]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit alpha V

decreases expression

ISO

Acetylcysteine results in decreased expression of ITGAV mRNA

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

integrin subunit beta 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [DDT results in increased expression of ITGB1 mRNA]

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

jagged canonical Notch ligand 1

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of JAG1 mRNA
Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of JAG1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of JAG1 mRNA]

PMID:16084531 PMID:20974985

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:144,859,453...144,894,872

G

Janus kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of JAK1 protein]

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]
N-acetyl-L-cysteine inhibits the reaction [hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum]
N-acetyl-L-cysteine inhibits the reaction [Ginkgoic acid decreases phosphorylation of JAK2 protein in stomach]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of JAK2 protein in the stomach)
Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JAK2 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of JAK2 protein]

CTD
RGD

PMID:12847270 PMID:29894800 PMID:34627931 PMID:29575334 PMID:32106377 More...

RGD:149735333, RGD:127284886, RGD:127284846

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases activity
multiple interactions

ISO
EXP

Acetylcysteine results in decreased activity of JUN protein
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN]; Acetylcysteine inhibits the reaction [darinaparsin results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Indican results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of JUN protein]
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased localization of and results in increased activity of JUN protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Chromium results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Acetylcysteine inhibits the reaction [zinc chloride results in increased expression of JUN mRNA]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of JUN protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of and results in increased phosphorylation of JUN protein]; Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA]; Acetylcysteine promotes the reaction [bis(maltolato)oxovanadium(IV) results in decreased activity of [FOS protein binds to JUN protein]]

PMID:7743507 PMID:8797811 PMID:8825185 PMID:8853906 PMID:9043100 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA]

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

type I keratin KA11

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KA11 mRNA

NCBI chr10:85,661,820...85,667,785
Ensembl chr10:85,638,182...85,664,898

G

potassium voltage-gated channel subfamily H member 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCNH5 mRNA

NCBI chr 6:99,350,947...99,643,856
Ensembl chr 6:99,360,302...99,643,856

G

potassium voltage-gated channel subfamily Q member 5

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCNQ5 mRNA
Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of KCNQ5 mRNA]

PMID:22129741 PMID:31004932

NCBI chr 9:31,326,595...31,892,399
Ensembl chr 9:31,329,497...31,891,304

G

potassium channel tetramerization domain containing 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KCTD4 mRNA

NCBI chr15:57,675,024...57,686,816
Ensembl chr15:57,673,741...57,687,798

G

lysine demethylase 2A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KDM2A protein]
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [KDM2A protein binds to CDKN2A promoter]]

NCBI chr 1:211,041,859...211,125,749
Ensembl chr 1:211,041,885...211,084,479

G

kinase insert domain receptor

increases expression

ISO

Acetylcysteine results in increased expression of KDR protein

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]; Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]
Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in decreased expression of KEAP1 protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of KEAP1 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]

PMID:11909699 PMID:19033392 PMID:30104959 PMID:37353053 PMID:37369159

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

kinesin family member 2C

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of KIF2C protein]

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

KIT ligand

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of KITLG protein]

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:36,782,638...36,863,793

G

Klotho

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein]
Acetylcysteine results in increased expression of KL protein
Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]; Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]

PMID:21389697 PMID:23183129 PMID:23765110

NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015

G

KLF transcription factor 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of KLF4 mRNA]

NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592

G

kallikrein 1-related peptidase C10

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of KLK3 mRNA]

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

lysine methyltransferase 2A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KMT2A protein]

NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317

G

KRAS proto-oncogene, GTPase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [manumycin results in decreased activity of KRAS protein]

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

kringle containing transmembrane protein 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of KREMEN2 mRNA

NCBI chr10:13,267,986...13,272,103
Ensembl chr10:13,267,986...13,271,986

G

keratin 10

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of KRT10 protein]

NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160

G

keratin 8

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased phosphorylation of KRT8 protein]

NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403

G

lysosomal-associated membrane protein 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]
Acetylcysteine affects the reaction [Arsenic Trioxide results in increased expression of LAMP1 mRNA]; Acetylcysteine affects the reaction [Arsenic Trioxide results in increased expression of LAMP1 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LAMP1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 mRNA]

PMID:28347754 PMID:29307831 PMID:31319114 PMID:33462182 PMID:35550146

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

lysosomal-associated membrane protein 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Lipopolysaccharides results in decreased expression of LAMP2 protein]

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:121,922,187...122,087,675

G

lactate dehydrogenase A

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased secretion of LDHA protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased secretion of LDHA protein]
Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased secretion of LDHA protein]; Acetylcysteine inhibits the reaction [DDT results in increased expression of LDHA mRNA]; Acetylcysteine inhibits the reaction [icaritin results in decreased expression of LDHA protein]

PMID:30821169 PMID:31251971 PMID:31724279 PMID:36000575 PMID:38408632 More...

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

galectin-like

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LGALSL mRNA

NCBI chr14:99,198,340...99,205,846
Ensembl chr14:99,198,339...99,206,487

G

luteinizing hormone subunit beta

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Acetylcysteine results in increased expression of LHB protein
Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of LHB protein]

PMID:21220312 PMID:30633982

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM homeobox 8

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LHX8 mRNA

NCBI chr 2:245,904,712...245,929,376
Ensembl chr 2:245,904,712...245,929,376

G

lipase E, hormone sensitive type

multiple interactions

ISO

Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of LIPE protein]

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117

G

lamin B1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of and affects the localization of LMNB1 protein]

NCBI chr18:52,373,939...52,413,284
Ensembl chr18:52,373,757...52,413,283

G

lon peptidase 1, mitochondrial

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of LONP1 mRNA]

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427

G

lipin 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

leucine-rich repeat kinase 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of LRRK2 protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of LRRK2 mRNA]; Acetylcysteine inhibits the reaction [Lead results in increased expression of LRRK2 mRNA]

PMID:34816377 PMID:34897981

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

lymphocyte antigen 9

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LY9 mRNA

NCBI chr13:86,610,762...86,633,314
Ensembl chr13:86,611,784...86,657,293

G

lysophospholipase-like 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LYPLAL1 mRNA

NCBI chr13:100,158,060...100,189,339
Ensembl chr13:100,158,060...100,189,503

G

lysozyme-like 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LYZL4 mRNA

NCBI chr 8:130,125,641...130,132,872
Ensembl chr 8:130,125,642...130,138,700

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]

NCBI chr 7:10,686,920...10,690,322
Ensembl chr 7:10,686,250...10,690,322

G

monoamine oxidase A

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of MAOA protein]

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased metabolism of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Acrolein results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [aumolertinib results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [butein results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Deuterium Oxide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [dimethyl alpha-ketoglutarate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Vorinostat results in increased cleavage of MAP1LC3B protein]; Acetylcysteine promotes the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein]; Cadmium Chloride promotes the reaction [Acetylcysteine results in increased expression of MAP1LC3B protein modified form]; Cadmium Chloride promotes the reaction [Acetylcysteine results in increased expression of MAP1LC3B protein]
Acetylcysteine results in increased expression of MAP1LC3B protein; Acetylcysteine results in increased expression of MAP1LC3B protein modified form
Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion affects the expression of and results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [cupric chloride results in increased expression of MAP1LC3B protein modified form]; Acetylcysteine inhibits the reaction [dibromoacetonitrile results in increased expression of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Indican results in increased expression of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate affects the localization of MAP1LC3B protein]
Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [LAMP1 protein co-treated with MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [RAB7A protein co-treated with MAP1LC3B protein]]; Acetylcysteine inhibits the reaction [nonylphenol results in increased expression of MAP1LC3B protein]

PMID:20543569 PMID:25301941 PMID:27832966 PMID:28347754 PMID:28600121 More...

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA]
Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]

PMID:28153600 PMID:28499986

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 3

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K3 protein]

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen activated protein kinase kinase 4

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]
N-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix]
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAP2K4 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K4 protein]

CTD
RGD

PMID:18703135 PMID:22085843 PMID:25198898

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen-activated protein kinase kinase 6

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP2K6 protein]

NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]
N-acetyl-L-cysteine co-treated with Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix
Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Acetylcysteine inhibits the reaction [platycodin D affects the phosphorylation of and results in increased activity of MAP3K5 protein]; Acetylcysteine inhibits the reaction [Quercetin results in decreased phosphorylation of and results in increased activity of MAP3K5 protein]

CTD
RGD

PMID:16449798 PMID:18703135 PMID:20083342 PMID:22784044 PMID:33039870 More...

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

EXP
ISO

Acetylcysteine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [antimony trichloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [dihydromyricetin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [sepantronium results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Thiostrepton results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK1 protein; Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Acetylcysteine affects the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of and results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [raiser results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Acetylcysteine results in increased phosphorylation of MAPK1 protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK1 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]]
Acetylcysteine results in decreased phosphorylation of MAPK1 protein

PMID:8616849 PMID:10658192 PMID:12065697 PMID:12690112 PMID:12717738 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in increased phosphorylation of and results in increased activity of MAPK10 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in increased phosphorylation of and results in increased activity of MAPK10 protein]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen-activated protein kinase 11

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK11 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK11 protein]

PMID:37295304 PMID:38642822

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen-activated protein kinase 12

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK12 protein]

PMID:37295304 PMID:38642822

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 13

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK13 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK13 protein]
Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK13 protein]

PMID:28087840 PMID:37295304 PMID:38642822

NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191

G

mitogen activated protein kinase 14

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Emodin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [icaritin results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK14 protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK14 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK14 protein]
Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein]

PMID:12684028 PMID:14729614 PMID:15650392 PMID:17237268 PMID:18703135 More...

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
decreases phosphorylation

EXP
ISO

Acetylcysteine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [antimony trichloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of and results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Daunorubicin results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [dihydromyricetin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK3 protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [morusin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Quinacrine results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [sepantronium results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [shikonin results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Thimerosal results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Thiostrepton results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [tomentosin results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of MAPK3 protein; Acetylcysteine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Acetylcysteine affects the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[cobaltous chloride results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK3 protein modified form]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK3 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of and results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [raiser results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Acetylcysteine results in increased phosphorylation of MAPK3 protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK3 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine affects the reaction [Phytol promotes the reaction [alpha-MSH results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [[tungsten carbide co-treated with Cobalt] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK3 protein modified form]; Acetylcysteine inhibits the reaction [Indican results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Acetylcysteine promotes the reaction [Polymyxin B inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]]
Acetylcysteine results in decreased phosphorylation of MAPK3 protein

PMID:8616849 PMID:12065697 PMID:12690112 PMID:12717738 PMID:14516795 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
decreases phosphorylation

EXP
ISO

Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [aureusidin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of MAPK8 mRNA]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased expression of MAPK8 mRNA]
N-acetyl-L-cysteine inhibits the reaction [Curcumin increases phosphorylation of MAPK8 protein in uterine cervix]
Acetylcysteine results in decreased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [8-bromo-7-methoxychrysin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Vorinostat] results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [butein results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz metabolite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [efavirenz results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [isoliensinine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [mevastatin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [oxophenylarsine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Spermine results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK8 protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK8 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Oxidopamine promotes the reaction [MAPK8 protein binds to and results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]

CTD
RGD

PMID:10397638 PMID:11306679 PMID:12684028 PMID:12902192 PMID:14687664 More...

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
decreases phosphorylation

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK9 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK9 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK9 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]]; Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Biological Products results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [maduramicin results in increased phosphorylation of MAPK9 protein]
Acetylcysteine results in decreased phosphorylation of MAPK9 protein
Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of and results in increased activity of MAPK9 protein]; Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [longikaurin A results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [mevastatin results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK9 protein]
Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK9 protein]

PMID:14687664 PMID:18412143 PMID:19654923 PMID:19760616 PMID:21135414 More...

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MAPK activated protein kinase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of MAPKAPK2 protein]

NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326

G

MAPK activated protein kinase 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MAPKAPK3 mRNA]

NCBI chr 8:116,808,429...116,842,228
Ensembl chr 8:116,808,429...116,842,228

G

microtubule-associated protein tau

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MAPT protein]
Acetylcysteine inhibits the reaction [1,2-diacetylbenzene results in increased phosphorylation of MAPT protein]

PMID:24142891 PMID:28734998

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of MCL1 protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Vorinostat] results in decreased expression of MCL1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of MCL1 protein]; Acetylcysteine inhibits the reaction [sepantronium results in decreased expression of MCL1 protein]
Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of MCL1 mRNA]

PMID:15173093 PMID:21533816 PMID:23082001 PMID:31837377 PMID:31900833

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

minichromosome maintenance 8 homologous recombination repair factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein]

NCBI chr 3:140,539,590...140,569,891
Ensembl chr 3:140,539,647...140,569,891

G

malic enzyme 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ME1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA]

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of METTL14 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of METTL14 protein]
Acetylcysteine inhibits the reaction [Paraquat results in increased expression of METTL14 mRNA]

PMID:31004932 PMID:34425375

NCBI chr 2:214,215,165...214,231,412
Ensembl chr 2:214,215,165...214,231,412

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of METTL3 mRNA]
Acetylcysteine inhibits the reaction [Paraquat results in increased expression of METTL3 mRNA]

PMID:31004932 PMID:34425375

NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487

G

mitofusin 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MFN1 protein]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of MFN1 protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of MFN1 protein]
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of MFN1 protein]

PMID:31408635 PMID:33161305 PMID:37084995 PMID:37499777

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

mitofusin 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [ALB protein modified form results in decreased expression of MFN2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of MFN2 protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of MFN2 protein]
Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MFN2 protein]

PMID:27997345 PMID:31408635 PMID:33161305 PMID:37084995 PMID:37499777

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:163,587,463...163,618,495

G

O-6-methylguanine-DNA methyltransferase

multiple interactions
increases expression
decreases activity

ISO

Acetylcysteine results in increased expression of and results in increased activity of MGMT protein
Acetylcysteine results in increased expression of MGMT mRNA
Acetylcysteine results in decreased activity of MGMT protein

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microRNA 143

multiple interactions
increases expression

EXP

Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of MIR143 mRNA]
Acetylcysteine results in increased expression of MIR143 mRNA

NCBI chr18:57,371,349...57,371,453

G

microRNA 144

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of MIR144 mRNA]

NCBI chr10:63,459,397...63,459,479
Ensembl chr10:63,459,397...63,459,479

G

microRNA 182

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MIR182 mRNA]

NCBI chr 4:59,752,246...59,752,307

G

microRNA 21

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of MIR21 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions affects the expression of MIR21 mRNA]
Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR21 mRNA]

PMID:23584289 PMID:27323401 PMID:31928237

NCBI chr10:71,902,600...71,902,691

G

microRNA 23b

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of MIR23B mRNA]

NCBI chr17:1,819,386...1,819,482

G

microRNA 26a-1

multiple interactions

ISO

[Acetylcysteine co-treated with necrostatin-1] results in decreased expression of MIR26A1

NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:127,633,048...127,633,137

G

microRNA 28

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of MIR28 mRNA]

NCBI chr11:89,480,252...89,480,337

G

microRNA 29b-1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of MIR29B1 mRNA]

NCBI chr 4:60,618,334...60,618,414

G

microRNA 761

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of MIR761 mRNA]

NCBI chr 5:129,005,205...129,005,280
Ensembl chr 5:129,005,205...129,005,280

G

melanocyte inducing transcription factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of MITF protein]]

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790

G

marker of proliferation Ki-67

multiple interactions

ISO

Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of MKI67 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of MKI67 protein]

PMID:31518672 PMID:32745510

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

modulator of VRAC current 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MLC1 mRNA

NCBI chr 7:121,926,356...121,949,484
Ensembl chr 7:121,926,356...121,946,698

G

mutL homolog 1

multiple interactions

ISO

[Acetylcysteine co-treated with Hydrogen Peroxide] results in increased expression of MLH1 mRNA; Acetylcysteine inhibits the reaction [sodium arsenite affects the expression of MLH1 protein]

PMID:28690196 PMID:29854080

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011

G

mixed lineage kinase domain like pseudokinase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased expression of and results in increased phosphorylation of MLKL protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of MLKL mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of MLKL protein]]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MLKL protein]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of MLKL protein]
[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MLKL mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MLKL protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MLKL mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MLKL protein]]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of MLKL protein]

PMID:30378427 PMID:35833596 PMID:36000575 PMID:37422542 PMID:37678662 More...

NCBI chr19:56,186,860...56,213,886
Ensembl chr19:56,186,860...56,213,858

G

matrix metallopeptidase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Acetylcysteine inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of MMP1 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of MMP1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]

PMID:17449795 PMID:19136476 PMID:21635667 PMID:29731195

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 10

multiple interactions

ISO

Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP10 protein]

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

matrix metallopeptidase 12

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:12,866,641...12,884,478

G

matrix metallopeptidase 13

multiple interactions

ISO

Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 protein]]

PMID:17395008 PMID:34791735

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 2

multiple interactions
decreases activity

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MMP2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of MMP2 protein]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of MMP2 mRNA]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of MMP2 mRNA]; Acetylcysteine inhibits the reaction [tomentosin results in decreased activity of MMP2 protein]
Acetylcysteine results in decreased activity of MMP2 protein

PMID:15451797 PMID:15962302 PMID:16213474 PMID:21540248 PMID:21635667 More...

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 25

multiple interactions

ISO

Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of MMP25 mRNA]

NCBI chr10:13,164,974...13,180,503
Ensembl chr10:13,164,977...13,180,503

G

matrix metallopeptidase 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]]

PMID:17395008 PMID:34791735

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 7

multiple interactions

ISO

Acetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Acetylcysteine inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

matrix metallopeptidase 9

multiple interactions
decreases activity

ISO
EXP

Acetylcysteine inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of MMP9 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]
Acetylcysteine results in decreased activity of MMP9 protein
[Ethanol co-treated with Dietary Fats co-treated with Acetylcysteine] results in increased expression of MMP9 mRNA; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [RELA protein binds to MMP9 promoter]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Acetylcysteine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]

PMID:15451797 PMID:15557194 PMID:15962302 PMID:16213474 PMID:16251475 More...

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

modulator of apoptosis 1

decreases expression

ISO

Acetylcysteine results in decreased expression of MOAP1 mRNA

NCBI chr 6:127,647,389...127,649,324
Ensembl chr 6:127,613,488...127,669,324

G

Mov10 like RNA helicase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MOV10L1 mRNA

NCBI chr 7:121,949,743...122,015,042
Ensembl chr 7:121,949,822...122,015,042

G

myeloperoxidase

multiple interactions

ISO
EXP

[MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine]; Acetylcysteine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Acetylcysteine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]
[Ethanol co-treated with Lipopolysaccharides co-treated with Acetylcysteine] results in increased activity of MPO protein; Acetylcysteine inhibits the reaction [arachidonyl-2-chloroethylamide results in increased activity of MPO protein]
Acetylcysteine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Gentamicins results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]; Acetylcysteine inhibits the reaction [Paraquat results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Smoke results in increased activity of MPO protein]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased activity of MPO protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased activity of MPO protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]]

PMID:11470263 PMID:17216608 PMID:17603938 PMID:20885979 PMID:22664789 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

melanocortin 2 receptor accessory protein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MRAP mRNA

NCBI chr11:43,477,382...43,489,118
Ensembl chr11:43,478,001...43,489,118

G

mannose receptor, C type 1

multiple interactions

ISO

[Paraquat co-treated with Acetylcysteine] results in decreased expression of MRC1 mRNA; [Paraquat co-treated with Acetylcysteine] results in decreased expression of MRC1 protein

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

membrane spanning 4-domains A8

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MS4A8A mRNA

NCBI chr 1:217,155,557...217,169,151
Ensembl chr 1:217,155,557...217,169,215

G

mesogenin 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MSGN1 mRNA

NCBI chr 6:39,631,868...39,632,508
Ensembl chr 6:39,631,584...39,632,538

G

mutS homolog 2

multiple interactions

ISO

Acetylcysteine affects the reaction [Cadmium Chloride results in decreased expression of MSH2 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of MSH2 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite affects the expression of MSH2 protein]

PMID:28690196 PMID:33971260

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

mutS homolog 6

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of MSH6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of MSH6 protein]

NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844

G

methionine sulfoxide reductase B1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of MSRB1 mRNA]

NCBI chr10:14,269,414...14,275,140
Ensembl chr10:14,269,414...14,274,184

G

myostatin

decreases expression
multiple interactions

EXP
ISO

Acetylcysteine results in decreased expression of MSTN mRNA; Acetylcysteine results in decreased expression of MSTN protein
Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased expression of MSTN mRNA]

PMID:16968467 PMID:35567930

NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:55,944,513...55,950,913

G

mitochondrially encoded ATP synthase membrane subunit 6

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP6 mRNA]

NCBI chr MT:7,919...8,599
Ensembl chr MT:7,904...8,584

G

mitochondrially encoded ATP synthase membrane subunit 8

multiple interactions

EXP

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of ATP8 mRNA]

NCBI chr MT:7,758...7,961
Ensembl chr MT:7,743...7,946

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX1 mRNA]; Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of COX1 mRNA]

PMID:26980303 PMID:30104959

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded cytochrome b

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CYTB mRNA]
Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of CYTB mRNA]

PMID:30104959 PMID:30998386

NCBI chr MT:14,136...15,278
Ensembl chr MT:14,124...15,266

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND1 mRNA]

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND2 mRNA]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of ND2 mRNA]
Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND2 mRNA]

PMID:30104959 PMID:30998386 PMID:35403558

NCBI chr MT:3,904...4,942
Ensembl chr MT:3,892...4,929

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND5 mRNA]
Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND5 mRNA]

PMID:30104959 PMID:30998386

NCBI chr MT:11,736...13,565
Ensembl chr MT:11,721...13,553

G

metallothionein 1, pseudogene 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1E mRNA]

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of MT1 mRNA]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]]
[MT1 protein co-treated with MT2 protein] affects the reaction [Acetylcysteine affects the susceptibility to Doxorubicin]

PMID:9152014 PMID:20600803 PMID:25724285 PMID:27151894

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]
Acetylcysteine results in decreased expression of MT2A mRNA
Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]; Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]; Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]
[MT1 protein co-treated with MT2 protein] affects the reaction [Acetylcysteine affects the susceptibility to Doxorubicin]

PMID:9545559 PMID:18586083 PMID:19097988 PMID:20600803 PMID:25724285 More...

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

mechanistic target of rapamycin kinase

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MTOR protein]
Acetylcysteine inhibits the reaction [Paraquat results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of MTOR protein]
Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of MTOR mRNA]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Biological Products results in decreased expression of MTOR protein modified form]; Acetylcysteine inhibits the reaction [butein results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Cannabidiol results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in decreased phosphorylation of MTOR protein]

PMID:21195169 PMID:23000059 PMID:26804764 PMID:27106530 PMID:28025121 More...

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of MTR mRNA]

NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MUC5AC mRNA]; Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MUC5AC protein]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC mRNA]; Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in increased expression of MUC5AC protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MUC5AC mRNA]

PMID:10640773 PMID:20709182 PMID:25177032 PMID:31622892 PMID:33421718

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

mucin 5B, oligomeric mucus/gel-forming

multiple interactions

ISO

Acetylcysteine inhibits the reaction [decabromobiphenyl ether results in increased expression of MUC5B mRNA]; Acetylcysteine inhibits the reaction [decabromobiphenyl ether results in increased expression of MUC5B protein]

NCBI chr 1:206,346,400...206,378,367
Ensembl chr 1:206,346,400...206,378,367

G

mucin 6, oligomeric mucus/gel-forming

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MUC6 mRNA

NCBI chr 1:206,155,826...206,194,384
Ensembl chr 1:206,155,593...206,191,864

G

MX dynamin like GTPase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of MX1 mRNA]]

NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of MYC protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Cisplatin] results in decreased expression of MYC protein]; Acetylcysteine inhibits the reaction [Hydrocarbons, Chlorinated analog results in increased expression of MYC protein]; Acetylcysteine inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein]
Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of MYC protein]
Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MYC mRNA]; Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of MYC mRNA]; Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]

PMID:15945272 PMID:16497787 PMID:21600978 PMID:22129741 PMID:24355586 More...

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

Mycbp associated protein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MYCBPAP mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of MYCBPAP mRNA]

NCBI chr10:79,947,200...79,967,857
Ensembl chr10:79,947,200...79,967,918

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO

[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein; [Particulate Matter co-treated with Acetylcysteine] results in increased secretion of MYD88 protein; Acetylcysteine inhibits the reaction [benzanthrone results in increased expression of MYD88 protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MYD88 mRNA]; MYD88 protein affects the reaction [[Acetylcysteine co-treated with Particulate Matter] results in increased secretion of CCL3 protein]; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine co-treated with Polymyxin B] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [[Particulate Matter co-treated with Acetylcysteine] results in increased secretion of MYD88 protein]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]
Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of MYD88 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]

PMID:28495615 PMID:28555929 PMID:36055550 PMID:37369159

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

myosin heavy chain 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYH3 protein]

NCBI chr10:52,269,185...52,293,000
Ensembl chr10:52,269,185...52,293,000

G

myogenin

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of MYOG mRNA
Acetylcysteine inhibits the reaction [Indican results in decreased expression of MYOG protein]

PMID:22129741 PMID:29380555

NCBI chr13:48,297,476...48,300,065
Ensembl chr13:48,297,235...48,300,065

G

N-acetyl-alpha-glucosaminidase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased activity of NAGLU protein]

NCBI chr10:86,501,864...86,509,333
Ensembl chr10:86,501,836...86,509,315

G

Nanog homeobox

multiple interactions

ISO

Acetylcysteine inhibits the reaction [ovatodiolide results in decreased expression of NANOG protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NANOG protein]

PMID:32745510 PMID:39276908

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

nibrin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]

NCBI chr 5:34,256,678...34,291,163
Ensembl chr 5:34,256,627...34,291,162

G

neural cell adhesion molecule 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NCAM2 mRNA

NCBI chr11:33,591,748...34,078,788
Ensembl chr11:33,591,713...34,078,788

G

neutrophil cytosolic factor 1

decreases expression
multiple interactions

EXP
ISO

Acetylcysteine results in decreased expression of NCF1 protein
Acetylcysteine inhibits the reaction [Aldrin results in increased expression of NCF1 mRNA]; Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of NCF1 mRNA]; Acetylcysteine inhibits the reaction [Endosulfan results in increased expression of NCF1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein]

PMID:21195169 PMID:28273962 PMID:29087013

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

neutrophil cytosolic factor 2

decreases expression
multiple interactions

EXP

Acetylcysteine results in decreased expression of NCF2 protein
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149

G

neutrophil cytosolic factor 4

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein]
Acetylcysteine results in decreased expression of NCF4 protein

NCBI chr 7:111,705,926...111,723,893
Ensembl chr 7:111,706,520...111,723,898

G

nuclear receptor coactivator 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein]

NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,401,802...7,415,840

G

NADH:ubiquinone oxidoreductase subunit B6

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Galactosamine results in decreased expression of NDUFB6 mRNA]
Acetylcysteine results in increased expression of NDUFB6 protein

NCBI chr 5:60,196,585...60,206,152
Ensembl chr 5:60,196,585...60,206,055

G

NADH:ubiquinone oxidoreductase core subunit S7

increases expression

ISO

Acetylcysteine results in increased expression of NDUFS7 protein

NCBI chr 7:10,103,226...10,110,862
Ensembl chr 7:10,103,227...10,110,691

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

ISO

Acetylcysteine results in decreased expression of NEDD9 mRNA

NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668

G

neurofilament heavy chain

multiple interactions

EXP

Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of NEFH protein]

NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417

G

neurofilament light chain

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr15:46,477,330...46,481,203
Ensembl chr15:46,458,204...46,482,515

G

NIMA-related kinase 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NEK4 mRNA

NCBI chr16:6,151,292...6,200,280
Ensembl chr16:6,151,368...6,198,450

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to Cadmium] which affects the expression of NFATC1 protein]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; Acetylcysteine affects the reaction [sodium arsenite affects the expression of NFATC1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of NFATC1 protein]

PMID:30742845 PMID:38896780

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

nuclear factor of activated T-cells 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic affects the localization of NFATC3 protein]

NCBI chr19:50,870,464...50,944,992
Ensembl chr19:50,870,489...50,944,992

G

nuclear factor, erythroid 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of NFE2 mRNA]

NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:136,261,236...136,268,585

G

NFE2 like bZIP transcription factor 1

multiple interactions

ISO

Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to Cadmium] which affects the expression of NFE2L1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of NFE2L1 protein]

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression
increases expression
affects localization

ISO
EXP

[6-formylindolo(3,2-b)carbazole co-treated with Acetylcysteine] results in decreased expression of NFE2L2 mRNA; [Acetylcysteine co-treated with Particulate Matter] results in decreased expression of NFE2L2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to Cadmium] which affects the expression of NFATC1 protein]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to Cadmium] which affects the expression of NFE2L1 protein]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of CTSK mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of VMA21 mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter analog affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog affects the localization of NFE2L2 protein]
Acetylcysteine results in decreased expression of NFE2L2 mRNA
Acetylcysteine results in increased expression of NFE2L2 mRNA; Acetylcysteine results in increased expression of NFE2L2 protein
Acetylcysteine affects the localization of NFE2L2 protein
Acetylcysteine affects the reaction [Chlorpyrifos affects the expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Ammonium Chloride results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [dimethoxyethyl phthalate results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [flutriafol results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of NFE2L2 promoter]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Indomethacin results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [NFE2L2 protein affects the reaction [Silver results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine inhibits the reaction [NFE2L2 protein affects the susceptibility to Silver]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Silver analog results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; Acetylcysteine inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sulforaphane results in increased phosphorylation of and results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of NFE2L2 protein]
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased activity of NFE2L2 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; [Particulate Matter co-treated with Acetylcysteine] results in increased expression of NFE2L2 protein; Acetylcysteine affects the reaction [yttrium chloride affects the expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [triptolide affects the expression of NFE2L2 protein]; Acetylcysteine promotes the reaction [Acrylamide results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; Sodium Fluoride promotes the reaction [Acetylcysteine affects the localization of NFE2L2 protein]

PMID:11909699 PMID:15322212 PMID:16631525 PMID:16806455 PMID:16959797 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor, interleukin 3 regulated

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NFIL3 mRNA

NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826

G

nuclear factor kappa B subunit 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of NFKB1 protein]]
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFKB1 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]
Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of NFKB1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of NFKB1 protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in decreased activity of NFKB1 protein]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Acetylcysteine inhibits the reaction [phosphoaspirin results in decreased activity of NFKB1 protein]; Acetylcysteine inhibits the reaction [Sulindac analog results in decreased activity of NFKB1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of NFKB1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of NFKB1 protein]; Acetylcysteine inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]

PMID:11970852 PMID:18922898 PMID:19642688 PMID:21600978 PMID:21741372 More...

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKB2 protein]]

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions
affects expression
decreases degradation

ISO
EXP

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of NFKBIA protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NFKBIA protein]; Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of NFKBIA protein]; Acetylcysteine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of NFKBIA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of NFKBIA protein]
Acetylcysteine affects the expression of NFKBIA protein
Acetylcysteine results in decreased degradation of NFKBIA protein
Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in increased expression of NFKBIA protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of NFKBIA protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [piperlongumine analog inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]

PMID:10636889 PMID:10921504 PMID:15949477 PMID:16214328 PMID:18404532 More...

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [oenothein B results in decreased phosphorylation of NFKBIB protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]

PMID:10381628 PMID:30452899

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

nerve growth factor

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [NGF protein results in increased localization of and results in increased activity of PRKCE protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [NGF protein results in increased phosphorylation of MAPK3 protein]
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of NGF mRNA]

PMID:16603213 PMID:18375950 PMID:23472850

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

neuroligin 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter]

NCBI chr X:70,469,251...70,497,380
Ensembl chr X:70,469,457...70,497,379

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

ISO
EXP

Acetylcysteine affects the reaction [diallyl trisulfide results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 mRNA]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]
Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of NLRP3 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 mRNA]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of NLRP3 protein]]
Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 mRNA]; Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Atrazine results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of NLRP3 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NLRP3 protein]
Acetylcysteine results in increased expression of NLRP3 mRNA; Acetylcysteine results in increased expression of NLRP3 protein

PMID:24885895 PMID:26086368 PMID:26435000 PMID:26901245 PMID:28004443 More...

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of NOS2 mRNA]
Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; Acetylcysteine inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [orazipone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of NOS2 protein]
Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [diethyl maleate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS2 mRNA]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS2 protein]

PMID:7532384 PMID:9826428 PMID:9918918 PMID:16140881 PMID:18039960 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions
increases expression

EXP
ISO

Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Triglycerides results in decreased expression of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]]
Acetylcysteine inhibits the reaction [Aldrin results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Endosulfan results in increased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 mRNA]; Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [TNF results in decreased expression of NOS3 protein]
Acetylcysteine results in increased expression of NOS3 protein

PMID:16140881 PMID:17026986 PMID:17321519 PMID:19837105 PMID:21912612 More...

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cypermethrin results in decreased expression of NOTCH2 protein]

NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823

G

NADPH oxidase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

NADPH oxidase 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NOX4 protein]; Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of AIF1 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of CS protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL6 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of PKM protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]]
Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 protein]

PMID:21131394 PMID:21616140 PMID:24224404 PMID:30037311 PMID:36762617 More...

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

neuronal PAS domain protein 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPAS2 mRNA

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

neuropeptide FF-amide peptide precursor

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NPFF mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NPFF mRNA]

NCBI chr 7:135,533,050...135,533,839
Ensembl chr 7:135,533,051...135,533,839

G

nucleophosmin 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to arsenic trioxide]; Acetylcysteine inhibits the reaction [NPM1 protein mutant form results in increased susceptibility to Bortezomib]

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:18,245,740...18,256,024
Ensembl chr X:18,245,740...18,256,024

G

neuropeptide Y

multiple interactions

ISO

Acetylcysteine affects the reaction [bisphenol A affects the expression of NPY mRNA]

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO
EXP

[Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] which results in decreased expression of NQO1 mRNA; Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Aspirin analog results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [NQO1 protein results in increased susceptibility to 9,10-phenanthrenequinone]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter analog results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; Acetylcysteine inhibits the reaction [sulforaphane results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NQO1 mRNA]; Acetylcysteine promotes the reaction [ochratoxin A results in increased expression of NQO1 protein]; NQO1 protein promotes the reaction [Acetylcysteine results in decreased susceptibility to 9,10-phenanthrenequinone]
Acetylcysteine results in increased expression of NQO1 mRNA; Acetylcysteine results in increased expression of NQO1 protein
[Acetylcysteine co-treated with Sodium Fluoride] results in increased expression of NQO1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]; Acetylcysteine promotes the reaction [Sodium Fluoride results in increased expression of NQO1 protein]
[Acetylcysteine co-treated with chromium trioxide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NQO1 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NQO1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of NQO1 mRNA]; Acetylcysteine promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein]

PMID:12730081 PMID:15044633 PMID:16274885 PMID:16920990 PMID:19033392 More...

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [flutriafol results in increased expression of NQO2 mRNA]

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 2, group E, member 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Benzo(a)pyrene results in decreased expression of NR2E3 protein]

NCBI chr 8:69,261,343...69,269,081
Ensembl chr 8:69,261,343...69,269,081

G

nuclear receptor subfamily 3, group C, member 1

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of NR3C1 mRNA
Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of NR3C1 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of NR3C1 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C1 mRNA]

PMID:16084531 PMID:25617244

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of NR3C2 mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of NR3C2 mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of NR3C2 mRNA]

NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078

G

nuclear respiratory factor 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of NRF1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of NRF1 mRNA]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of NRF1 mRNA]; Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of NRF1 mRNA]

PMID:21775390 PMID:26980303 PMID:35403558 PMID:36493885

NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:59,632,372...59,738,353

G

neurexin 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter]

NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374

G

neurotrophin 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of NTF3 protein]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:160,600,770...160,676,349

G

nth-like DNA glycosylase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NTHL1 mRNA]

NCBI chr10:14,160,334...14,166,502
Ensembl chr10:14,160,330...14,166,966

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of NTRK1 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]

NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:175,534,844...175,551,787

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]
Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased phosphorylation of NTRK2 protein]

PMID:28499986 PMID:38642822

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

NUAK family kinase 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NUAK2 mRNA

NCBI chr13:46,305,744...46,322,755
Ensembl chr13:46,305,975...46,322,748

G

nuclear protein 1, transcriptional regulator

multiple interactions

EXP
ISO

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NUPR1 mRNA
Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NUPR1 mRNA]

PMID:22129741 PMID:31319114

NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901

G

occludin

multiple interactions

ISO
EXP

[ginsenoside Rg3 co-treated with Acetylcysteine] inhibits the reaction [Glucose results in decreased expression of OCLN protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of OCLN protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of OCLN protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of OCLN protein]
Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of OCLN protein]
Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of OCLN protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of OCLN mRNA]

PMID:29235125 PMID:32683294 PMID:32687961 PMID:33485121 PMID:34906888 More...

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

O-GlcNAcase

decreases expression

ISO

Acetylcysteine results in decreased expression of OGA mRNA

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

oxidized low density lipoprotein receptor 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of OLR1 protein]

PMID:16055083 PMID:24145059

NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598

G

olfactory receptor 1093

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OLR1093 mRNA

NCBI chr 7:13,225,805...13,226,761
Ensembl chr 7:13,225,805...13,226,761

G

olfactory receptor 1451

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OLR1451 mRNA

NCBI chr10:43,928,730...43,929,659
Ensembl chr10:43,928,730...43,929,659

G

olfactory receptor 1481

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OLR1481 mRNA

NCBI chr10:58,736,375...58,737,319
Ensembl chr10:58,736,375...58,737,319

G

olfactory receptor 59

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OLR59 mRNA

NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:166,604,141...166,623,265

G

oligodendrocyte-myelin glycoprotein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OMG mRNA

NCBI chr10:64,959,316...64,962,050
Ensembl chr10:64,936,145...64,962,050

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form]; Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased ubiquitination of OPA1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]
Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of OPA1 protein]

PMID:20678484 PMID:37084995 PMID:37499777

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

G

olfactory receptor family 10 subfamily AL member 5B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR10AL5B mRNA

NCBI chr20:803,673...816,671
Ensembl chr20:743,522...816,076

G

olfactory receptor family 12 subfamily K member 8

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR12K8 mRNA

NCBI chr 3:41,013,406...41,014,398
Ensembl chr 3:41,013,406...41,014,398

G

olfactory receptor family 13 subfamily A member 27

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR13A27 mRNA

NCBI chr 1:204,665,234...204,666,166
Ensembl chr 1:204,665,234...204,666,169

G

olfactory receptor family 1 subfamily F member 30

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR1F30 mRNA

NCBI chr10:12,987,662...12,988,603
Ensembl chr10:12,987,707...12,990,402

G

olfactory receptor family 2 subfamily AK member 5F

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR2AK6 mRNA

NCBI chr10:43,768,636...43,769,550

G

olfactory receptor family 2 subfamily N member 1E

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR2N1E mRNA

NCBI chr20:181,280...182,218
Ensembl chr20:181,280...182,218

G

olfactory receptor family 2 subfamily T member 48E

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR2T48E mRNA

NCBI chr10:43,190,786...43,191,715

G

olfactory receptor family 4 subfamily A member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4A2 mRNA

NCBI chr 3:95,894,195...95,895,112
Ensembl chr 3:95,894,195...95,895,112

G

olfactory receptor family 4 subfamily A member 77D

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4A77D mRNA

NCBI chr 3:96,252,954...96,253,904
Ensembl chr 3:96,252,954...96,253,904

G

olfactory receptor family 4 subfamily C member 105B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4C105B mRNA

NCBI chr 3:94,914,483...94,915,412
Ensembl chr 3:94,914,483...94,915,412

G

olfactory receptor family 4 subfamily F member 4B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4F4B mRNA

NCBI chr 3:118,512,583...118,516,477
Ensembl chr 3:118,512,119...118,516,477

G

olfactory receptor family 4 subfamily P member 20B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4P20B mRNA

NCBI chr 3:94,478,375...94,479,295

G

olfactory receptor family 4 subfamily S member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4S2 mRNA

NCBI chr 3:94,833,695...94,834,630
Ensembl chr 3:94,833,674...94,834,630

G

olfactory receptor family 51 subfamily AF member 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR51AF1 mRNA

NCBI chr 1:167,276,439...167,277,398
Ensembl chr 1:167,276,439...167,277,398

G

olfactory receptor family 51 subfamily I member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR51I2 mRNA

NCBI chr 1:167,925,559...167,926,497
Ensembl chr 1:167,925,559...167,926,497

G

olfactory receptor family 5 subfamily AK member 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR5AK4 mRNA

NCBI chr 3:90,825,550...90,859,032

G

olfactory receptor family 5 subfamily AS member 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR5AS1 mRNA

NCBI chr 3:92,780,992...92,781,930
Ensembl chr 3:92,780,992...92,781,930

G

olfactory receptor family 5 subfamily D member 41

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR5D41 mRNA

NCBI chr 3:94,093,130...94,094,080
Ensembl chr 3:94,093,130...94,094,080

G

olfactory receptor family 5 subfamily P member 53

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR5P53 mRNA

NCBI chr 1:171,225,321...171,226,253
Ensembl chr 1:171,225,321...171,226,253

G

olfactory receptor family 6 subfamily B member 13

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR6B13 mRNA

NCBI chr 1:204,433,297...204,434,253
Ensembl chr 1:204,433,297...204,434,253

G

olfactory receptor family 6 subfamily D member 13

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR6D13 mRNA

NCBI chr 4:151,368,443...151,369,426

G

olfactory receptor family 6 subfamily D member 13C

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR6D13C mRNA

NCBI chr 4:151,424,750...151,425,733
Ensembl chr 4:151,424,750...151,425,733

G

olfactory receptor family 7 subfamily E member 166

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR7E166 mRNA

NCBI chr 8:25,972,927...25,973,856
Ensembl chr 8:25,967,492...25,973,856

G

olfactory receptor family 7 subfamily G member 29

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR7G29 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of OR7G29 mRNA]

NCBI chr 8:25,525,259...25,526,197
Ensembl chr 8:25,525,259...25,526,197

G

olfactory receptor family 8 subfamily B member 9

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR8B9 mRNA

NCBI chr 8:45,840,270...45,841,205
Ensembl chr 8:45,840,270...45,841,205

G

olfactory receptor family 8 subfamily G member 2C

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR8G2C mRNA

NCBI chr 8:49,123,496...49,124,419
Ensembl chr 8:49,123,496...49,124,419

G

ORMDL sphingolipid biosynthesis regulator 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]

NCBI chr10:84,086,317...84,092,673
Ensembl chr10:84,086,317...84,093,548

G

oxidative stress responsive serine-rich 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of OSER1 mRNA]

NCBI chr 3:172,486,417...172,504,607
Ensembl chr 3:172,486,440...172,504,597

G

oxidative stress induced growth inhibitor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Docosahexaenoic Acids results in increased expression of OSGIN1 protein]

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

otoancorin

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OTOA mRNA

NCBI chr 1:185,074,271...185,142,149
Ensembl chr 1:185,074,268...185,141,658

G

purinergic receptor P2X 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]; Acetylcysteine inhibits the reaction [Rotenone promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]

NCBI chr12:51,999,107...52,002,627
Ensembl chr12:51,999,372...52,002,627

G

purinergic receptor P2X 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of P2RX5 mRNA

NCBI chr10:58,276,329...58,291,108
Ensembl chr10:58,276,257...58,287,935

G

p21 (RAC1) activated kinase 6

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PAK6 mRNA

NCBI chr 3:126,092,576...126,128,320
Ensembl chr 3:126,093,013...126,128,318

G

progestin and adipoQ receptor family member 9

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PAQR9 mRNA

NCBI chr 8:104,993,884...104,996,180
Ensembl chr 8:104,993,827...104,998,285

G

Parkinsonism associated deglycase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased oxidation of PARK7 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]; Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of PARK7 protein]

PMID:18377993 PMID:20851755 PMID:32540572 PMID:34897981

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825

G

poly (ADP-ribose) polymerase 1

increases cleavage
decreases expression
multiple interactions

ISO
EXP

Acetylcysteine results in increased cleavage of PARP1 protein
Acetylcysteine results in decreased expression of PARP1 protein modified form
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Gentamicins results in increased activity of PARP1 protein]
[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; [Acetylcysteine results in increased susceptibility to 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] which results in increased cleavage of PARP1 protein; [Glucose deficiency co-treated with Acetylcysteine] results in increased cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[CSC-3436 co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [ABBV-744 results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of PARP1 mRNA]; Acetylcysteine inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [chloropicrin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [isoliensinine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [oxophenylarsine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [pendulone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Plant Extracts results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [tomentosin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of PARP1 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased cleavage of PARP1 protein]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of PARP1 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein]

PMID:11470263 PMID:14660655 PMID:14687664 PMID:15375156 PMID:15496615 More...

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]; Acetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 protein]

NCBI chr 1:3,932,161...3,980,751
Ensembl chr 1:3,932,161...3,964,848

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PCNA protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of PCNA protein]
Acetylcysteine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

PMID:31551408 PMID:33485121 PMID:33797725

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[tungsten carbide analog co-treated with Cobalt analog] results in decreased expression of PDCD4 protein]
Acetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]

PMID:23758151 PMID:27323401

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

programmed cell death 6 interacting protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [hesperetin results in decreased expression of PDCD6IP protein]

NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993

G

phosphodiesterase 6B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PDE6B mRNA

NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,468,302...1,511,435

G

platelet derived growth factor subunit B

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]; Acetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PDGFB protein]

PMID:22700867 PMID:26138014

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PDGFRB mRNA]
Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]

PMID:21134390 PMID:23392711

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

pyruvate dehydrogenase E1 subunit alpha 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 mRNA]; Acetylcysteine inhibits the reaction [epigallocatechin gallate results in decreased expression of PDHA1 protein]

NCBI chr X:38,509,158...38,522,986
Ensembl chr X:38,509,084...38,522,536

G

pyruvate dehydrogenase kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PDK1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of PDK1 protein]

PMID:17171638 PMID:30821169 PMID:31251971 PMID:31724279 PMID:39490166

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

pyruvate dehydrogenase kinase 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

PDZ and LIM domain 5

decreases expression

ISO

Acetylcysteine results in decreased expression of PDLIM5 mRNA

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

peroxisomal biogenesis factor 11 alpha

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PEX11A mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PEX11A mRNA]

NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645

G

phosphogluconate dehydrogenase

increases activity

EXP

Acetylcysteine results in increased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

progesterone receptor

multiple interactions
decreases secretion

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of PGR mRNA]
Acetylcysteine results in decreased secretion of PGR protein
Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased secretion of PGR protein]

PMID:18829485 PMID:21220312 PMID:30648648

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

phosphatidylinositol glycan anchor biosynthesis, class A

increases expression

ISO

Acetylcysteine results in increased expression of PIGA mRNA

NCBI chr X:33,672,832...33,687,747
Ensembl chr X:33,674,923...33,687,636

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone results in decreased phosphorylation of PIK3R1 protein]; Acetylcysteine inhibits the reaction [Deuterium Oxide results in decreased phosphorylation of PIK3R1 protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of TNF protein]]

PMID:28836394 PMID:37751786 PMID:38521250

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

Pim-1 proto-oncogene, serine/threonine kinase

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIM1 mRNA

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,556,113...7,561,764

G

Pim-2 proto-oncogene, serine/threonine kinase

increases expression

ISO

Acetylcysteine results in increased expression of PIM2 mRNA

NCBI chr X:17,289,509...17,294,778
Ensembl chr X:17,289,509...17,294,778

G

PTEN induced kinase 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased expression of PINK1 protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1 mRNA]; Acetylcysteine inhibits the reaction [Lead results in increased expression of PINK1 mRNA]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein]

PMID:25464205 PMID:29567065 PMID:33161305 PMID:34547296 PMID:34816377 More...

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

prolactin induced protein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIP mRNA

NCBI chr 4:71,754,265...71,758,559
Ensembl chr 4:71,754,265...71,758,559

G

paired Ig-like receptor B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of LILRB3 mRNA

NCBI chr 1:74,414,556...74,433,015
Ensembl chr 1:74,331,291...74,422,116

G

piwi-like RNA-mediated gene silencing 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PIWIL4 mRNA

NCBI chr 8:19,817,985...19,861,327
Ensembl chr 8:19,817,986...19,861,419

G

pyruvate kinase M1/2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of PKM protein]]; Acetylcysteine inhibits the reaction [quinone results in increased degradation of PKM protein]
Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of PKM mRNA]; Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of PKM protein]; Acetylcysteine inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PKM protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PKM protein]; Acetylcysteine inhibits the reaction [DDT results in increased expression of and affects the localization of PKM protein alternative form]; Acetylcysteine inhibits the reaction [DDT results in increased expression of PKM mRNA alternative form]; Acetylcysteine inhibits the reaction [icaritin results in decreased expression of PKM protein]

PMID:25437431 PMID:28284859 PMID:30821169 PMID:31251971 PMID:31724279 More...

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase A2 group 4A

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of PLA2G4A mRNA]

PMID:15683734 PMID:16603213

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

plasminogen activator, urokinase

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of PLAU mRNA
Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased secretion of PLAU protein]

PMID:15962302 PMID:16084531

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase D1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]

NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245

G

phospholipase D2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]

NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435

G

perilipin 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PLIN2 mRNA

NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878

G

phospholipid phosphatase related 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PLPPR1 mRNA

NCBI chr 5:68,232,963...68,520,784
Ensembl chr 5:68,232,963...68,592,444

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2-xylene results in increased expression of PMAIP1 mRNA]; Acetylcysteine inhibits the reaction [Benzene results in increased expression of PMAIP1 mRNA]; Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PMAIP1 mRNA]; Acetylcysteine inhibits the reaction [Toluene results in increased expression of PMAIP1 mRNA]

PMID:18723479 PMID:21144877

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

patatin-like phospholipase domain containing 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of PNPLA3 mRNA]

NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:117,173,516...117,194,594

G

patatin-like phospholipase domain containing 5

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PNPLA5 mRNA

NCBI chr 7:117,126,046...117,137,036
Ensembl chr 7:117,126,046...117,137,036

G

proline-rich nuclear receptor coactivator 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PNRC1 mRNA

NCBI chr 5:52,443,400...52,489,303
Ensembl chr 5:52,443,400...52,446,491

G

RNA polymerase I and III subunit C

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Paraquat results in decreased methylation of POLR1C mRNA]

NCBI chr 9:22,233,318...22,237,430
Ensembl chr 9:22,233,305...22,237,428

G

proopiomelanocortin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [POMC protein promotes the reaction [cobaltous chloride results in increased activity of CASP3 protein]]

NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173

G

paraoxonase 1

multiple interactions

EXP

Acetylcysteine affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of PON1 protein]

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

paraoxonase 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein]

NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996

G

periostin

decreases expression

ISO

Acetylcysteine results in decreased expression of POSTN mRNA

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

POU class 5 homeobox 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [decabromobiphenyl ether results in decreased expression of POU5F1 protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in decreased expression of POU5F1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of POU5F1 protein]

PMID:26206603 PMID:32745510 PMID:39276908

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

Acetylcysteine results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

EXP
ISO

Acetylcysteine results in increased expression of PPARG mRNA; Acetylcysteine results in increased expression of PPARG protein
Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of PPARG protein]
Acetylcysteine inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and results in decreased phosphorylation of PPARG protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PPARG protein]
Acetylcysteine inhibits the reaction [yttrium chloride results in decreased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG protein]

PMID:16945329 PMID:17602960 PMID:22046279 PMID:23964924 PMID:27117918 More...

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Flavonoids results in increased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of PPARGC1A protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of PPARGC1A protein]
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]

PMID:21775390 PMID:23063593 PMID:26980303 PMID:30104959 PMID:30641872 More...

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

PPARG coactivator 1 beta

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1B mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1B protein]

NCBI chr18:57,029,264...57,131,466
Ensembl chr18:57,029,275...57,131,466

G

pro-platelet basic protein

multiple interactions

ISO

Acetylcysteine promotes the reaction [Cadmium Chloride results in decreased secretion of PPBP protein]

NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,586,495...17,587,299

G

protein phosphatase, Mg2+/Mn2+ dependent, 1A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein]

NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:97,174,916...97,216,574

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA]
Acetylcysteine inhibits the reaction [arsenite promotes the reaction [TARDBP protein binds to PPP1R15A protein]]

PMID:24291486 PMID:29109149

NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:105,136,525...105,139,774

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased methylation of and results in increased phosphorylation of PPP2CA protein]

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 2 scaffold subunit A beta

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPP2R1B protein]

NCBI chr 8:60,092,540...60,125,512
Ensembl chr 8:60,081,553...60,125,795

G

protein phosphatase 5, catalytic subunit

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPP5C protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C protein]

PMID:18703135 PMID:19038359

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

peroxiredoxin 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of PRDX1 mRNA]; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in decreased expression of PRDX1 protein]

PMID:30661989 PMID:33118390 PMID:39701484

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Thiostrepton affects the expression of PRDX3 protein modified form]

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

peroxiredoxin 5

multiple interactions

ISO

Acetylcysteine inhibits the reaction [PRKAA2 protein affects the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of PRDX5 protein]]

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020

G

proline rich protein HaeIII subfamily 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PRH1 mRNA

NCBI chr 4:168,275,152...168,279,011

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased phosphorylation of PRKAA1 protein]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of PRKAA1 mRNA]; Acetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Acetylcysteine inhibits the reaction [Quercetin results in increased phosphorylation of PRKAA1 protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased phosphorylation of PRKAA1 protein]

PMID:19293639 PMID:20083342 PMID:21195169 PMID:24386346 PMID:24535669 More...

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[PRKAA2 protein affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased phosphorylation of PRKAA2 protein]; Acetylcysteine inhibits the reaction [PRKAA2 protein affects the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of PRDX5 protein]]; Acetylcysteine inhibits the reaction [PRKAA2 protein affects the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]]

PMID:29753072 PMID:39260547

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

protein kinase C, delta

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]
Acetylcysteine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]

PMID:17171638 PMID:21362627 PMID:27658547 PMID:37308051

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

multiple interactions

EXP

Acetylcysteine inhibits the reaction [NGF protein results in increased localization of and results in increased activity of PRKCE protein]

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]
Acetylcysteine results in increased expression of PRKDC protein

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PRKN]; Acetylcysteine inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of PRKN mRNA]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PRKN mRNA]; Acetylcysteine inhibits the reaction [Lead results in increased expression of PRKN mRNA]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] affects the localization of and results in increased ubiquitination of PRKN protein]; Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein]

PMID:22872702 PMID:25464205 PMID:29567065 PMID:31368586 PMID:33161305 More...

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

prolactin

multiple interactions

EXP

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased secretion of PRL protein]

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prolactin family 7, subfamily B, member 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PRL7B1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PRL7B1 mRNA]

NCBI chr17:37,410,605...37,423,139
Ensembl chr17:37,414,947...37,423,126

G

prolactin receptor

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PRLR mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PRLR mRNA]

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

phosphoserine aminotransferase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PSAT1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PSAT1 mRNA]

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:222,623,556...222,655,693

G

proteasome 26S subunit, non-ATPase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Paraquat results in decreased methylation of PSMD1 mRNA]

NCBI chr 9:94,157,971...94,233,218
Ensembl chr 9:94,157,971...94,233,218

G

proteasome activator subunit 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of PSME4 mRNA]

NCBI chr14:108,706,643...108,810,330
Ensembl chr14:108,706,643...108,810,328

G

phosphatase and tensin homolog

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [YTHDF2 protein binds to PTEN mRNA]]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of and results in decreased activity of PTEN protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of PTEN mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of PTEN mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]

PMID:21195169 PMID:24449419 PMID:27022031 PMID:35430258 PMID:39490166

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

ISO
EXP

Acetylcysteine results in decreased expression of PTGS2 mRNA
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprostone]; Acetylcysteine inhibits the reaction [benzanthrone results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased expression of PTGS2]; Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; Acetylcysteine inhibits the reaction [Endosulfan results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [JP8 aviation fuel results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]]
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [[Formaldehyde co-treated with eugenol, zinc oxide dental cavity lining] results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [[IL1B protein co-treated with Oligomycins] results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Antimony results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Benzene results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of PTGS2 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of PTGS2 protein]]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride affects the localization of PTGS2 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [dentinol results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Estradiol promotes the reaction [[2-hydroxyestradiol co-treated with 4-hydroxyestradiol] results in increased expression of PTGS2 mRNA]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; Acetylcysteine inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Styrene results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Toluene results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
Acetylcysteine inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 mRNA]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]

PMID:14687664 PMID:15576159 PMID:15934011 PMID:16024921 PMID:16084531 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein]

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine kinase 2 beta

multiple interactions

EXP

Acetylcysteine inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

protein tyrosine kinase 6

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of PTK6 mRNA

NCBI chr 3:188,684,633...188,693,224
Ensembl chr 3:188,684,633...188,693,224

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]; Acetylcysteine inhibits the reaction [Pamidronate promotes the reaction [Arsenic Trioxide results in decreased expression of and results in decreased activity of PTPN1 protein]]; Acetylcysteine inhibits the reaction [Pamidronate results in decreased expression of and results in decreased activity of PTPN1 protein]; Acetylcysteine inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]

PMID:22917016 PMID:32337366

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

PYD and CARD domain containing

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of PYCARD protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [piperlongumine results in increased expression of PYCARD protein]; Quercetin promotes the reaction [Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of PYCARD protein]]
[(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid co-treated with Acetylcysteine] inhibits the reaction [Acetaminophen results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of PYCARD protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PYCARD protein]
Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of PYCARD mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of PYCARD protein]
Acetylcysteine results in increased expression of PYCARD protein

PMID:26079697 PMID:26435000 PMID:30977640 PMID:34791735 PMID:36055550 More...

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

glycogen phosphorylase L

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA]

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RAB24, member RAS oncogene family

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of RAB24 protein]

NCBI chr17:9,313,593...9,315,675
Ensembl chr17:9,313,593...9,316,575

G

RAB30, member RAS oncogene family

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RAB30 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RAB30 mRNA]

NCBI chr 1:156,216,137...156,310,778
Ensembl chr 1:156,216,137...156,310,778

G

RAB7A, member RAS oncogene family

multiple interactions

EXP

Acetylcysteine inhibits the reaction [cadmium acetate affects the localization of [RAB7A protein co-treated with MAP1LC3B protein]]

NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:121,983,938...122,064,185

G

Rac family small GTPase 1

multiple interactions
decreases expression

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]
Acetylcysteine results in decreased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Rac family small GTPase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Resveratrol affects the localization of RAC2 protein]

NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267

G

receptor for activated C kinase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of RACK1 mRNA]

NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,670,270...33,675,948

G

RAD1 checkpoint DNA exonuclease

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of RAD1 mRNA]

NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:61,188,727...61,196,867

G

RAD18 E3 ubiquitin protein ligase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein]

NCBI chr 4:147,291,463...147,376,904
Ensembl chr 4:147,291,276...147,376,869

G

RAD51 paralog B

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of RAD51B mRNA]

NCBI chr 6:103,829,390...104,373,923
Ensembl chr 6:103,829,554...104,374,509

G

RAD54 like

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of RAD54L mRNA]

NCBI chr 5:134,812,158...134,841,821
Ensembl chr 5:134,811,532...134,841,425

G

RAD9 checkpoint clamp component A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of RAD9A mRNA]

NCBI chr 1:210,917,970...210,983,038
Ensembl chr 1:210,917,970...210,925,161

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [NSC 680410 results in decreased expression of RAF1 protein]
Acetylcysteine inhibits the reaction [tubocapsenolide A results in increased degradation of RAF1 protein]
[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of RAF1 mRNA

PMID:16481037 PMID:18442981 PMID:22129741

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RB transcriptional corepressor 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of RB1 protein modified form]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased phosphorylation of RB1 protein]; Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]
Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of RB1 mRNA]

PMID:11139434 PMID:16497787 PMID:22927544 PMID:29859004

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

REL proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]
Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]

PMID:11970852 PMID:23114885

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation
decreases phosphorylation
increases activity
increases glutathionylation

ISO
EXP

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [[PRKAA2 protein affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Acetylcysteine promotes the reaction [Particulate Matter results in decreased phosphorylation of RELA protein]
Acetylcysteine results in increased phosphorylation of RELA protein
Acetylcysteine results in decreased phosphorylation of RELA protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [RELA protein binds to MMP9 promoter]; Acetylcysteine inhibits the reaction [Smoke affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein affects the localization of RELA protein]
[Acetylcysteine co-treated with oenothein B] results in decreased phosphorylation of RELA protein; [Acetylcysteine co-treated with TNF protein] results in decreased activity of RELA protein; Acetylcysteine affects the localization of and results in increased activity of RELA protein; Acetylcysteine affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of RELA protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Indican results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased phosphorylation of RELA protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in decreased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased acetylation of RELA protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of RELA protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased activity of RELA protein]
Acetylcysteine results in increased activity of RELA protein
Acetylcysteine results in increased glutathionylation of RELA protein

PMID:7491977 PMID:8760145 PMID:11970852 PMID:15139008 PMID:17925309 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein]
Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELB protein]]

PMID:11970852 PMID:19642688

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

renin

multiple interactions

EXP

Acetylcysteine inhibits the reaction [ioxitalamic acid results in increased expression of REN protein]

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

regulator of G-protein signaling 16

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

regulator of G-protein signaling like 2 homolog (mouse)

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RGSL2H mRNA

NCBI chr13:68,524,140...68,525,147
Ensembl chr13:68,524,140...68,525,147

G

Rho-related BTB domain containing 1

decreases expression

ISO

Acetylcysteine results in decreased expression of RHOBTB1 mRNA

NCBI chr20:19,326,197...19,455,182
Ensembl chr20:19,326,212...19,402,057

G

receptor interacting serine/threonine kinase 1

multiple interactions

ISO

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of RIPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of RIPK1 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of RIPK1 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of RIPK1 protein]]; Acetylcysteine affects the reaction [Benzo(a)pyrene affects the expression of RIPK1 protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK1 protein]
Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased expression of RIPK1 protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of RIPK1 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of RIPK1 protein]]

PMID:35777681 PMID:35833596 PMID:37422542 PMID:37678662 PMID:38408632

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

receptor-interacting serine-threonine kinase 3

multiple interactions

ISO
EXP

[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of RIPK3 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of RIPK3 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of RIPK3 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of RIPK3 protein]]; Acetylcysteine affects the reaction [Benzo(a)pyrene affects the expression of RIPK3 protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in increased phosphorylation of RIPK3 protein]
Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased expression of RIPK3 protein]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of RIPK3 mRNA]]; Acetylcysteine inhibits the reaction [bisphenol A promotes the reaction [Selenium deficiency results in increased expression of RIPK3 protein]]
Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein]

PMID:35777681 PMID:35833596 PMID:36000575 PMID:37422542 PMID:37678662 More...

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

ribonuclease A family member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RNASE2 mRNA

NCBI chr15:26,923,125...26,923,934
Ensembl chr15:26,923,134...26,923,955

G

ring finger protein 125

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RNF125 mRNA

NCBI chr18:12,528,995...12,550,646
Ensembl chr18:12,528,838...12,554,430

G

RAR-related orphan receptor A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RORA mRNA

NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:78,182,620...78,915,730

G

ribosomal protein S6 kinase B1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Chromium results in decreased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Zearalenone results in decreased phosphorylation of RPS6KB1 protein]
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]

PMID:14516795 PMID:18569013 PMID:21195169 PMID:24299490 PMID:26804764 More...

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

receptor (chemosensory) transporter protein 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of RTP1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of RTP1 mRNA]

NCBI chr11:90,927,633...90,930,149
Ensembl chr11:90,927,633...90,930,149

G

RUNX family transcription factor 2

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of RUNX2 mRNA]
Acetylcysteine inhibits the reaction [Dexamethasone affects the expression of RUNX2 mRNA]

PMID:19017541 PMID:24239970

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

retinoid X receptor alpha

multiple interactions

ISO

Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of RXRA mRNA]

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

S100 calcium binding protein A11

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of CASP9 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of PARP1 protein]

NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:181,875,130...181,880,541

G

S100 calcium-binding protein A4

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of S100A4 mRNA]

NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:178,388,526...178,390,837

G

S100 calcium binding protein A9

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of S100A9 protein]

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

spermidine/spermine N1-acetyl transferase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SAT1 mRNA]

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

stearoyl-CoA desaturase

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

short chain dehydrogenase/reductase family 16C, member 6

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SDR16C6 mRNA

NCBI chr 5:21,892,783...21,916,314
Ensembl chr 5:21,892,783...22,062,233

G

SEC31 homolog A, COPII coat complex component

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Paraquat results in increased methylation of SEC31A mRNA]

NCBI chr14:9,518,655...9,573,579
Ensembl chr14:9,518,648...9,573,585

G

selectin E

decreases expression
multiple interactions

ISO

Acetylcysteine results in decreased expression of SELE mRNA
Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein]
Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of SELE protein]]

PMID:16084531 PMID:19642688 PMID:26901245

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

selenoprotein I

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SELENOI mRNA

NCBI chr 6:31,792,972...31,831,170
Ensembl chr 6:31,792,973...31,831,523

G

serpin family H member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein]

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

sestrin 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of SESN2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Hemin results in increased expression of SESN2 protein]; Acetylcysteine inhibits the reaction [Quercetin results in increased expression of SESN2 protein]

PMID:24535669 PMID:29662624 PMID:31054940 PMID:31323261

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

secreted frizzled-related protein 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SFRP2 mRNA

NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:171,387,385...171,395,079

G

surfactant protein A1

multiple interactions

ISO

Acetylcysteine affects the reaction [Particulate Matter affects the expression of SFTPA1 protein]
Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of SFTPA1 protein]

PMID:31449845 PMID:35689653

NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,042,255...17,045,769

G

surfactant protein B

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of SFTPB protein]
Acetylcysteine results in increased expression of SFTPB protein
Acetylcysteine inhibits the reaction [[Air Pollutants, Occupational results in increased abundance of Particulate Matter] which results in decreased expression of SFTPB protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SFTPB protein]

PMID:27208422 PMID:35689653

NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:105,917,578...105,927,646

G

surfactant protein C

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of SFTPC protein
Acetylcysteine inhibits the reaction [[Air Pollutants, Occupational results in increased abundance of Particulate Matter] which results in decreased expression of SFTPC protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SFTPC protein]

NCBI chr15:52,006,274...52,009,324
Ensembl chr15:52,006,283...52,009,475

G

SHC adaptor protein 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [SHC1 protein results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [SHC1 protein results in increased expression of VIM protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of SHC1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SHC1 protein]

PMID:32659284 PMID:33360347

NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914

G

shisa family member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SHISA2 mRNA

NCBI chr15:37,982,913...37,987,211
Ensembl chr15:37,982,169...37,988,535

G

sirtuin 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA]; Acetylcysteine inhibits the reaction [antimony trichloride results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]
Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT1 protein]
Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of SIRT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]

PMID:21031461 PMID:30055241 PMID:33360347 PMID:36493885 PMID:38642822 More...

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 3

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT3 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 protein]
Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA]; Acetylcysteine inhibits the reaction [oxophenylarsine results in decreased expression of SIRT3 protein]

PMID:30104959 PMID:30641872 PMID:35430258 PMID:38865859

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

SKI3 subunit of superkiller complex

multiple interactions

EXP

Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNFRSF10B mRNA]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNFRSF10B protein]

NCBI chr 2:7,363,417...7,526,351
Ensembl chr 2:7,363,535...7,483,496

G

Src-like-adaptor 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLA2 mRNA

NCBI chr 3:165,821,164...165,848,087
Ensembl chr 3:165,828,657...165,847,062

G

solute carrier family 12 member 1

increases expression

EXP

Acetylcysteine results in increased expression of SLC12A1 protein

NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:132,859,590...132,936,340

G

solute carrier family 12 member 3

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC12A3 mRNA

NCBI chr19:10,636,594...10,690,008
Ensembl chr19:10,636,596...10,675,050

G

solute carrier family 14 member 2

multiple interactions
increases expression

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC14A2 mRNA
Acetylcysteine results in increased expression of SLC14A2 protein

PMID:22129741 PMID:23183129

Ensembl chr18:73,887,575...73,953,570

G

solute carrier family 19 member 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC19A2 mRNA]

NCBI chr13:79,135,118...79,149,316
Ensembl chr13:79,135,059...79,149,315

G

solute carrier family 1 member 1

multiple interactions

ISO

Acetylcysteine affects the reaction [SLC1A1 protein affects the transport of Zinc]; Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of SLC1A1 protein]; Acetylcysteine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the metabolism of SLC1A1 protein]

PMID:18093171 PMID:22575539

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:235,963,437...236,045,469

G

solute carrier family 1 member 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SLC1A2 protein]; Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]
Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 mRNA]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]

PMID:19717140 PMID:22895544 PMID:34310962

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 22, member 17

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SLC22A17 mRNA]

NCBI chr15:32,352,273...32,358,780
Ensembl chr15:32,349,944...32,358,785

G

solute carrier family 22, member 19

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of SLC22A24 protein]

NCBI chr 1:214,339,594...214,394,681
Ensembl chr 1:214,339,599...214,394,681

G

solute carrier family 22 member 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]

NCBI chr10:38,634,098...38,687,409
Ensembl chr10:38,634,098...38,679,920

G

solute carrier family 22 member 5

multiple interactions

EXP

Acetylcysteine affects the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]

NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077

G

solute carrier family 22 member 6

multiple interactions

ISO

adipic acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Glutarates inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]; Ketoglutaric Acids inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]; SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]; SLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury]; SLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Methylmercury Compounds]; SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]

PMID:12606766 PMID:15908511

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

multiple interactions

EXP

SLC22A8 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

solute carrier family 24 member 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC24A2 mRNA

NCBI chr 5:106,543,867...106,787,810
Ensembl chr 5:106,543,874...106,787,780

G

solute carrier family 25 member 20

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]

PMID:23402788 PMID:25849418

NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027

G

solute carrier family 25, member 47

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC25A47 mRNA

NCBI chr 6:133,531,741...133,537,375
Ensembl chr 6:133,531,728...133,537,877

G

solute carrier family 27 member 2

multiple interactions

EXP

[Acetylcysteine co-treated with Dietary Fats] results in increased expression of SLC27A2 mRNA

NCBI chr 3:134,258,101...134,295,581
Ensembl chr 3:134,258,101...134,295,581

G

solute carrier family 2 member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [DDT results in increased expression of SLC2A1 mRNA]; Acetylcysteine inhibits the reaction [icaritin results in decreased expression of SLC2A1 protein]

PMID:30821169 PMID:31251971 PMID:31724279 PMID:38431053

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of SLC2A3 mRNA]; Acetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of SLC2A3 protein]

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 30 member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC30A1 mRNA]

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 35 member D2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of SLC35D2 mRNA]

NCBI chr17:992,153...1,025,476
Ensembl chr17:993,646...1,025,475

G

solute carrier family 38, member 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenite results in increased expression of SLC38A2 mRNA]

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 14

increases expression

ISO

Acetylcysteine results in increased expression of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229

G

solute carrier family 40 member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA]

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:55,525,532...55,543,460

G

solute carrier family 4 member 1 (Diego blood group)

multiple interactions

EXP

[Acetylcysteine co-treated with Atorvastatin] inhibits the reaction [sodium arsenite affects the localization of SLC4A1 protein]

NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258

G

solute carrier family 5 member 5

multiple interactions

EXP

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SLC5A5 mRNA]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

solute carrier family 6 member 6

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC6A6 mRNA

NCBI chr 4:125,752,340...125,826,033
Ensembl chr 4:125,752,372...125,826,032

G

solute carrier family 7 member 11

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein]
Acetylcysteine inhibits the reaction [elesclomol results in increased expression of SLC7A11 mRNA]

PMID:18723479 PMID:19717140

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier family 7, member 14

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLC7A14 mRNA

NCBI chr 2:113,993,781...114,099,810
Ensembl chr 2:113,993,785...114,099,804

G

schlafen family member 9

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SLFN8 mRNA

NCBI chr10:68,406,641...68,420,062
Ensembl chr10:68,406,642...68,421,134

G

SMAD family member 1

decreases phosphorylation

ISO

Acetylcysteine results in decreased phosphorylation of SMAD1 protein

NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957

G

SMAD family member 2

multiple interactions
decreases phosphorylation

ISO

Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of SMAD2 mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of SMAD2 mRNA]
Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of SMAD2 protein]
Acetylcysteine results in decreased phosphorylation of SMAD2 protein

PMID:29408318 PMID:30317545 PMID:32947957 PMID:38488660

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 3

multiple interactions
decreases phosphorylation

ISO

[Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Water Pollutants, Chemical] results in decreased expression of SMAD3 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of SMAD3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of SMAD3 protein]
Acetylcysteine results in decreased phosphorylation of SMAD3 protein

PMID:21131394 PMID:29408318 PMID:30317545 PMID:34687772 PMID:38488660 More...

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

structural maintenance of chromosomes 1A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [resveratrol results in increased phosphorylation of SMC1A protein]

PMID:15489221 PMID:24933654

NCBI chr X:24,582,732...24,627,462
Ensembl chr X:24,582,690...24,627,462

G

snail family transcriptional repressor 1

multiple interactions
decreases expression

ISO

Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SNAI1 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]; Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]; Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of SNAI1 protein]; Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]; Acetylcysteine inhibits the reaction [propiconazole results in increased expression of SNAI1 protein]
Acetylcysteine results in decreased expression of SNAI1 protein

PMID:17596522 PMID:21635667 PMID:28284859 PMID:32687844 PMID:34170130 More...

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of SNAI2 protein]

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synuclein alpha

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]
Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SNCA mRNA]; Acetylcysteine inhibits the reaction [Lead results in increased expression of SNCA mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide analog results in increased expression of SNCA protein]

PMID:15114628 PMID:27613482 PMID:34816377

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

syntrophin, gamma 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SNTG1 mRNA

NCBI chr 5:14,769,290...15,583,468
Ensembl chr 5:15,046,102...15,583,468

G

superoxide dismutase 1

multiple interactions
decreases expression
increases activity

ISO
EXP

Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Antimony results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [bisphenol S results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of SOD1]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD1 protein]; Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [Lead results in decreased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of SOD1 protein]
[Acetylcysteine co-treated with Thapsigargin] results in decreased expression of SOD1 mRNA; Acetylcysteine affects the reaction [mono-(2-ethylhexyl)phthalate affects the activity of SOD1 protein]; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD1 protein]]; Acetylcysteine inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD1 protein]]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD1 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [perfluorooctanoic acid results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in decreased expression of SOD1 protein]
Acetylcysteine results in decreased expression of SOD1 mRNA
Acetylcysteine results in increased activity of SOD1 protein

PMID:16101137 PMID:17309078 PMID:19264484 PMID:19409983 PMID:20674559 More...

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions
increases expression

ISO
EXP

[Acetylcysteine results in increased expression of SOD2 protein] which results in decreased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[cupric chloride results in increased abundance of Copper] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased activity of SOD2 protein]]; Acetylcysteine inhibits the reaction [[lead acetate results in increased abundance of Lead] inhibits the reaction [[cupric chloride results in increased abundance of Copper] which results in increased activity of SOD2 protein]]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [Oxygen results in increased expression of SOD2 protein]
Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased acetylation of SOD2 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased acetylation of SOD2 protein]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of SOD2 mRNA]
Acetylcysteine results in increased expression of SOD2 mRNA; Acetylcysteine results in increased expression of SOD2 protein
[Acetylcysteine co-treated with IL1A protein] results in increased expression of SOD2 protein; [Acetylcysteine co-treated with TNF protein] results in increased expression of SOD2 protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] which results in decreased expression of SOD2 mRNA; Acetylcysteine affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Acetylcysteine affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Acetylcysteine inhibits the reaction [[[15-deoxyprostaglandin J2 results in increased activity of PPARG protein] which results in decreased expression of SOD2 protein] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Glucose deficiency affects the folding of SOD2 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [linsidomine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Peroxynitrous Acid results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of and results in increased activity of SOD2 protein]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR1 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of ESR2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of FKBP5 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD17B8 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of KLK3 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of PGR mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of RXRA mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of TMPRSS2 mRNA]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2]; Acetylcysteine promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Acetylcysteine promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Acetylcysteine results in increased expression of SOD2 mRNA]

PMID:7476933 PMID:8760145 PMID:9535218 PMID:9741582 PMID:11264281 More...

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

superoxide dismutase 3

multiple interactions

EXP

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of SOD3 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of SOD3 protein]

PMID:21804221 PMID:34358621

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

sorbitol dehydrogenase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Diclofenac results in increased secretion of SORD protein]

NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:129,638,302...129,686,100

G

SRY-box transcription factor 17

multiple interactions

ISO

N-acetyl-cysteine inhibits the reaction [angiotensin II decreases expression of SOX17 protein in retinal endothelial cells]

RGD

NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854

G

Sp1 transcription factor

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of SP1 protein]
Acetylcysteine results in decreased expression of SP1 protein

PMID:16928829 PMID:18556457 PMID:30851366 PMID:33360347

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

sphingosine kinase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein]

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

G

Spi-1 proto-oncogene

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of SPI1 mRNA]]; Acetylcysteine inhibits the reaction [cypermethrin inhibits the reaction [Tretinoin results in increased expression of SPI1 mRNA]]

NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SPOCK2 mRNA

NCBI chr20:28,580,262...28,607,198
Ensembl chr20:28,580,226...28,608,409

G

secreted phosphoprotein 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Allylamine results in increased expression of SPP1 mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]

PMID:15910882 PMID:19356721

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sequestosome 1

multiple interactions
increases expression

ISO
EXP

[Chloroquine co-treated with Acetylcysteine] results in increased expression of SQSTM1 mRNA; Acetylcysteine affects the reaction [sodium arsenite affects the expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [alpha-pyrrolidinononanophenone results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [aumolertinib results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [tri-o-cresyl phosphate results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [TRIM44 protein promotes the reaction [SQSTM1 protein binds to SQSTM1 protein]]
Acetylcysteine results in increased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [cupric chloride results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [tricalcium phosphate results in decreased expression of SQSTM1 protein]
Acetylcysteine inhibits the reaction [decamethrin results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of SQSTM1 protein]; Acetylcysteine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]

PMID:22927544 PMID:25301941 PMID:26588882 PMID:27106530 PMID:28063998 More...

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of SRC protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SRC protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of SRC protein]
N-acetyl-L-cysteine inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of SRC protein in the stomach)

CTD
RGD

PMID:21777978 PMID:29894800 PMID:31433961 PMID:29408335

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SRMS mRNA

NCBI chr 3:188,696,070...188,702,474
Ensembl chr 3:188,696,071...188,702,474

G

sulfiredoxin 1

multiple interactions

ISO

[Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [Cadmium Chloride results in increased expression of SRXN1 mRNA]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [Copper Sulfate results in increased expression of SRXN1 mRNA]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [diethyl maleate results in increased expression of SRXN1 mRNA]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [Methyl Methanesulfonate results in increased expression of SRXN1 mRNA]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [sodium arsenite results in increased expression of SRXN1 mRNA]

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

steroidogenic acute regulatory protein

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in decreased expression of STAR protein]
Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of STAR protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in decreased expression of STAR protein]
Acetylcysteine inhibits the reaction [anacetrapib results in increased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [dalcetrapib results in increased expression of STAR mRNA]; Acetylcysteine inhibits the reaction [torcetrapib results in increased expression of STAR mRNA]

PMID:25617244 PMID:26769589 PMID:29567110 PMID:30648648 PMID:36709824

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 1

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [Aluminum Chloride results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [Ozone results in increased phosphorylation of STAT1 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Acetylcysteine promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]

PMID:12847270 PMID:16896058 PMID:17607690 PMID:19061877 PMID:20525893 More...

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions
treatment
decreases phosphorylation

ISO
EXP

Acetylcysteine inhibits the reaction [1,2,5,8-tetrahydroxy anthraquinone results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein modified form]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STAT3 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [DDT results in increased phosphorylation of and results in increased expression of STAT3 protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of and results in decreased activity of STAT3 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]
N-acetyl-L-cysteine co-treated with Il-6 inhibits the reaction [apigenin-7-O-gentiobioside decreases phosphorylation of STAT3 protein in the stomach)
Acetylcysteine results in decreased phosphorylation of STAT3 protein
Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of STAT3 mRNA]; Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased methylation of STAT3 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]

CTD
RGD

PMID:16481037 PMID:16896058 PMID:17666914 PMID:19409983 PMID:21741372 More...

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stimulator of interferon response cGAMP interactor 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Ceruletide results in increased expression of STING1 protein]; Acetylcysteine promotes the reaction [saikosaponin D inhibits the reaction [Ceruletide results in increased expression of STING1 protein]]

NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,606,196...27,611,947

G

small ubiquitin-like modifier 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of SUMO1 mRNA]

NCBI chr 9:68,572,901...68,602,803
Ensembl chr 9:68,572,911...68,602,890

G

seminal vesicle secretory protein 3A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SVS3A mRNA

NCBI chr 3:173,377,977...173,383,302
Ensembl chr 3:173,381,085...173,383,301

G

synapsin I

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein]

PMID:27624276 PMID:28153600

NCBI chr X:3,725,745...3,780,940
Ensembl chr X:3,725,714...3,780,938

G

synaptophysin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

synaptotagmin 7

multiple interactions

EXP

[Acetylcysteine co-treated with Dexamethasone] results in decreased expression of SYT7 mRNA

NCBI chr 1:216,456,148...216,518,718
Ensembl chr 1:216,456,259...216,518,718

G

trace-amine-associated receptor 7e

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TAAR7E mRNA

NCBI chr 1:23,220,964...23,222,040
Ensembl chr 1:23,220,964...23,222,040

G

TGF-beta activated kinase 1/MAP3K7 binding protein 2

decreases binding

EXP

N-acetyl-cysteine inhibits binding of Traf6 protein to Tab2 in rat neonatal cardiomyocytes

RGD

NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485

G

transaldolase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Glutathione]; Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of NADP]; Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Nitric Oxide]; Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased phosphorylation of CTNNB1 protein]

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

TRAF family member-associated NFKB activator

decreases expression

ISO

Acetylcysteine results in decreased expression of TANK mRNA

NCBI chr 3:66,522,834...66,598,864
Ensembl chr 3:66,537,175...66,598,864

G

TAR DNA binding protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [arsenite promotes the reaction [TARDBP protein binds to PPP1R15A protein]]

NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:164,334,924...164,345,204

G

taste receptor, type 2, member 108

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TAS2R108 mRNA

NCBI chr 4:70,254,367...70,255,281
Ensembl chr 4:70,254,367...70,255,281

G

t-complex protein 10b

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TCP10B mRNA

NCBI chr 1:55,485,354...55,508,836
Ensembl chr 1:55,485,411...55,508,836

G

telomerase reverse transcriptase

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TERT protein]; Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TERT protein]
Acetylcysteine results in increased expression of TERT protein
Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased activity of TERT protein]; Acetylcysteine inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein]

PMID:18336854 PMID:19409983 PMID:30851366

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

tet methylcytosine dioxygenase 1

multiple interactions
increases expression

ISO
EXP

Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] promotes the reaction [TET1 protein binds to CDKN2A promoter]]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TET1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA]
[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with Acetylcysteine] results in decreased expression of TET1 mRNA; Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of TET1 mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased expression of TET1 mRNA]
Acetylcysteine results in increased expression of TET1 mRNA

PMID:28153600 PMID:31551408 PMID:33188856

NCBI chr20:25,766,806...25,839,598
Ensembl chr20:25,760,057...25,832,730

G

tet methylcytosine dioxygenase 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [dorsomorphin results in decreased expression of TET2 protein]

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186

G

transcription factor A, mitochondrial

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of TFAM mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of TFAM mRNA]; Acetylcysteine inhibits the reaction [Monocrotophos results in decreased expression of TFAM mRNA]; Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of TFAM mRNA]
Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of TFAM mRNA]; Acetylcysteine inhibits the reaction [dimethoxyethyl phthalate results in decreased expression of TFAM protein]

PMID:21775390 PMID:26980303 PMID:32142722 PMID:34214916 PMID:35403558 More...

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transcription factor binding to IGHM enhancer 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of TFE3 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased phosphorylation of and affects the localization of TFE3 protein]

PMID:29945972 PMID:32439580

NCBI chr X:17,401,466...17,414,829
Ensembl chr X:17,401,466...17,414,685

G

transcription factor EB

multiple interactions

ISO

Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of TFEB mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of TFEB protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of TFEB mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased phosphorylation of TFEB protein]

PMID:29307831 PMID:29945972 PMID:33462182 PMID:35550146 PMID:39701484

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transferrin receptor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Zinc deficiency results in increased expression of TFRC protein]

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor alpha

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339

G

transforming growth factor, beta 1

multiple interactions
decreases expression

ISO
EXP

Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of TGFB1 protein]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of TGFB1 mRNA]
Acetylcysteine results in decreased expression of TGFB1 mRNA; Acetylcysteine results in decreased expression of TGFB1 protein modified form
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TGFB1 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of TGFB1 protein]
Acetylcysteine inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased secretion of TGFB1 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of PPM1A protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of HGF protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of IL6 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of VEGFA protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]

PMID:16757516 PMID:21131394 PMID:21765237 PMID:23159718 PMID:23325087 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor beta 1 induced transcript 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased expression of TGFB1I1 mRNA]

NCBI chr 1:192,258,992...192,265,903
Ensembl chr 1:192,258,598...192,265,903

G

transforming growth factor, beta 3

multiple interactions

ISO

[Acetylcysteine co-treated with Cadmium] results in decreased expression of TGFB3 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of and results in increased secretion of TGFB3 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of TGFB3 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of and results in increased secretion of TGFB3 protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of and results in increased secretion of TGFB3 protein]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of TGFB3 mRNA]

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transforming growth factor, beta receptor 1

decreases expression
multiple interactions

EXP
ISO

Acetylcysteine results in decreased expression of TGFBR1 mRNA; Acetylcysteine results in decreased expression of TGFBR1 protein
[Acetylcysteine co-treated with Cadmium] results in decreased expression of TGFBR1 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of TGFBR1 mRNA]; Acetylcysteine inhibits the reaction [Water Pollutants, Chemical results in increased expression of TGFBR1 mRNA]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]

PMID:17602960 PMID:29408318

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

transforming growth factor, beta receptor 2

decreases expression
multiple interactions

EXP

Acetylcysteine results in decreased expression of TGFBR2 mRNA; Acetylcysteine results in decreased expression of TGFBR2 protein
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transglutaminase 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Particulate Matter analog results in decreased activity of TGM1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in decreased activity of TGM1 protein]

NCBI chr15:33,160,985...33,175,632
Ensembl chr15:33,160,987...33,174,463

G

transglutaminase 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Particulate Matter analog results in decreased activity of TGM2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog results in decreased activity of TGM2 protein]

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

tyrosine hydroxylase

multiple interactions
decreases expression

EXP

[Ascorbic Acid co-treated with alpha-Tocopherol co-treated with Acetylcysteine] results in decreased expression of TH protein; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
Acetylcysteine results in decreased expression of TH protein

PMID:22714038 PMID:25891525

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

thrombospondin 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of TSP1 mRNA]

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

thrombopoietin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [THPO protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of GP1BA protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGA2B protein]; Acetylcysteine inhibits the reaction [THPO protein results in increased expression of ITGB3 protein]

Ensembl chr11:93,686,834...93,693,320

G

translocase of inner mitochondrial membrane 23

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of TIMM23 protein]

NCBI chr16:7,416,590...7,442,681
Ensembl chr16:7,416,597...7,442,658
Ensembl chr 3:7,416,597...7,442,658
Ensembl chr 6:7,416,597...7,442,658

G

TIMP metallopeptidase inhibitor 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of TIMP1 protein]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of TIMP2 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP2 mRNA]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

increases expression
multiple interactions

EXP

Acetylcysteine results in increased expression of TIMP3 mRNA
Acetylcysteine inhibits the reaction [[[Cadmium Chloride results in increased abundance of Cadmium] which co-treated with hydroquinone] results in decreased expression of TIMP3 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TIMP3 mRNA]; Acetylcysteine inhibits the reaction [hydroquinone results in decreased expression of TIMP3 mRNA]

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

tight junction protein 1

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of TJP1 protein]; Acetylcysteine inhibits the reaction [tributyltin results in decreased expression of TJP1 protein]
[Acetylcysteine co-treated with ginsenoside Rg3] inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of TJP1 protein]
Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TJP1 mRNA]; Acetylcysteine inhibits the reaction [Glucose results in decreased expression of TJP1 protein]

PMID:26079211 PMID:27783111 PMID:29235125 PMID:32687961 PMID:33485121 More...

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tight junction protein 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Glucose results in decreased expression of TJP2 protein]

NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750

G

toll-like receptor 2

decreases expression

ISO

Acetylcysteine results in decreased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

multiple interactions
decreases expression

ISO

Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; Acetylcysteine inhibits the reaction [benzanthrone results in increased expression of TLR4 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of TLR4 protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TLR4 mRNA]
Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of TLR4 protein]
Acetylcysteine results in decreased expression of TLR4 mRNA

PMID:19627980 PMID:22385246 PMID:28495615 PMID:36055550 PMID:37369159 More...

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane protein 140

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TMEM140 mRNA

NCBI chr 4:64,503,621...64,514,620
Ensembl chr 4:64,500,439...64,521,990

G

transmembrane protein 41B

multiple interactions

ISO

[Chloroquine co-treated with Acetylcysteine] results in decreased expression of TMEM41B mRNA

NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:173,447,367...173,461,597

G

tenascin C

decreases expression

ISO

Acetylcysteine results in decreased expression of TNC mRNA

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

decreases expression
multiple interactions
affects expression

ISO
EXP

Acetylcysteine results in decreased expression of TNF mRNA; Acetylcysteine results in decreased expression of TNF protein
[Acetylcysteine co-treated with TNF protein] results in decreased activity of RELA protein; [Acetylcysteine co-treated with TNF protein] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [2,4-decadienal results in increased expression of and results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP7 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNF protein co-treated with Diclofenac] results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [piperlongumine analog inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of SOD2]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK14 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [TNF results in decreased expression of NOS3 protein]; Acetylcysteine inhibits the reaction [TNF results in increased abundance of Malondialdehyde]; Acetylcysteine inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of TNF protein]]; Acetylcysteine promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Acetylcysteine results in increased expression of SOD2 mRNA]
[Acetylcysteine co-treated with raubasine] results in increased secretion of TNF protein; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of TNF mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of TNF protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [azoxystrobin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fungal Polysaccharides results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [PRKAA2 protein affects the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; MYD88 protein affects the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]; MYD88 protein affects the reaction [Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]]; Polymyxin B promotes the reaction [Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]]
Acetylcysteine affects the expression of TNF protein
Acetylcysteine analog inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of TNF protein]; Acetylcysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [cupric chloride results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Mechlorethamine results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Nitric Oxide deficiency results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Palmitates results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [TNF protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; Acetylcysteine promotes the reaction [caryophyllene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; Acetylcysteine promotes the reaction [Doxorubicin results in increased expression of TNF mRNA]

PMID:7476933 PMID:7532384 PMID:8760145 PMID:9535218 PMID:9721806 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 6

multiple interactions

ISO

Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

TNF receptor superfamily member 10b

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in increased expression of TNFRSF10A protein]; Acetylcysteine inhibits the reaction [ilimaquinone results in increased expression of TNFRSF10A mRNA]; Acetylcysteine inhibits the reaction [pendulone results in increased expression of TNFRSF10A protein]

PMID:21741372 PMID:24930757 PMID:35288263

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 13C

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TNFRSF13C mRNA

NCBI chr 7:115,616,139...115,618,647
Ensembl chr 7:115,616,303...115,618,620

G

TNF receptor superfamily member 1A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of TNFRSF1A protein]; Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein]

PMID:15550384 PMID:21741372

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TNF superfamily member 10

decreases expression
decreases response to substance
multiple interactions

ISO

Acetylcysteine results in decreased expression of TNFSF10 mRNA
Acetylcysteine results in decreased susceptibility to TNFSF10 protein
Acetylcysteine inhibits the reaction [[CSC-3436 co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of CASP8 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in decreased expression of CFLAR protein modified form]]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [TNFSF10 protein affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BCL2L1 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BID protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in decreased expression of BIRC5 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased chemical synthesis of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of VDAC1 protein]

PMID:16084531 PMID:20971099 PMID:23711929 PMID:25034532 PMID:25619640 More...

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 11

multiple interactions

ISO

[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; [Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of CTSK mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNFSF11]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA]

PMID:30742845 PMID:38971422

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 4

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TNFSF4 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TNFSF4 mRNA]

NCBI chr13:76,256,654...76,280,133
Ensembl chr13:76,256,654...76,280,133

G

troponin I3, cardiac type

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[Lithium Carbonate results in increased abundance of Lithium] which results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

transportin 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [manumycin results in decreased expression of TNPO1]

NCBI chr 2:31,941,731...32,034,366
Ensembl chr 2:31,941,731...32,034,326

G

translocase of outer mitochondrial membrane 20

multiple interactions

ISO

Acetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of TOMM20 protein]
Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of TOMM20 protein]

PMID:33161305 PMID:36739042

NCBI chr19:71,822,429...71,832,420
Ensembl chr19:71,822,411...71,832,510

G

torsin family 3, member A

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TOR3A mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TOR3A mRNA]

NCBI chr13:71,324,073...71,348,625
Ensembl chr13:71,324,076...71,348,624

G

tumor protein p53

multiple interactions
increases expression
decreases expression
decreases activity

ISO
EXP

Acetylcysteine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased activity of TRP53 protein]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased expression of TRP53 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in increased phosphorylation of TRP53 protein]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [quinone analog results in increased expression of TRP53 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of TRP53 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased expression of TRP53 protein]
Acetylcysteine results in increased expression of TP53 protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Aflatoxin B1 promotes the reaction [fumonisin B1 results in increased expression of TP53 protein]]; Acetylcysteine inhibits the reaction [Aflatoxin B1 results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Aflatoxin B1 results in increased expression of TP53 protein]]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Potassium Dichromate results in increased expression of TP53 protein]
Acetylcysteine results in decreased expression of TP53 protein
Acetylcysteine results in decreased activity of TP53 protein
[Acetylcysteine co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; [chloroquine diphosphate co-treated with Acetylcysteine] results in decreased localization of TP53 protein; [Hydroxychloroquine co-treated with Acetylcysteine] results in decreased localization of TP53 protein; Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; Acetylcysteine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of TP53 protein modified form]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; Acetylcysteine inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [[Cisplatin co-treated with Arsenic Trioxide] results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; Acetylcysteine inhibits the reaction [Capsaicin results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of TP53]; Acetylcysteine inhibits the reaction [Cisplatin results in increased glutathionylation of TP53 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of and results in increased activity of TP53 protein]; Acetylcysteine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [cypermethrin results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [hesperetin results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [icaritin results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [Methotrexate results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [N-acetylsphingosine results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Oxaliplatin results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of TP53 protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased expression of TP53]; Acetylcysteine inhibits the reaction [Phytochemicals results in increased phosphorylation of TP53 protein]; Acetylcysteine inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of TP53 mRNA]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of TP53 protein]; Acetylcysteine inhibits the reaction [TP53 protein results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]; Acetylcysteine promotes the reaction [Chlorine results in increased expression of TP53 protein modified form]

PMID:9535218 PMID:10951577 PMID:11864783 PMID:14871840 PMID:15059885 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tropomyosin 1

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Allylamine results in increased expression of TPM1 mRNA]

NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:76,511,871...76,543,468

G

thyroid peroxidase

multiple interactions

EXP

Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of TPO mRNA]

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

Tnf receptor-associated factor 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

TNF receptor associated factor 6

decreases binding
multiple interactions

EXP

N-acetyl-cysteine inhibits binding of Traf6 protein to Tab2 in rat neonatal cardiomyocytes
N-acetyl-L-cysteine inhibits the reaction [angiotensin II increases expression of Traf6 protein in rat neonatal cardiomyocytes]

RGD

PMID:27249171 PMID:27249171

RGD:155646134, RGD:155646134

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

tribbles pseudokinase 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRIB1 mRNA

NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:93,095,973...93,117,480

G

tribbles pseudokinase 3

multiple interactions

ISO
EXP

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of TRIB3 mRNA]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]

PMID:18723479 PMID:24291486

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 28

multiple interactions

ISO

Acetylcysteine inhibits the reaction [resveratrol results in increased phosphorylation of TRIM28 protein]

NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:82,724,838...82,731,572

G

tripartite motif-containing 44

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TRIM44 protein promotes the reaction [SQSTM1 protein binds to SQSTM1 protein]]

NCBI chr 3:109,048,643...109,183,821
Ensembl chr 3:109,048,643...109,183,821

G

trophinin associated protein

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TROAP mRNA

NCBI chr 7:132,111,892...132,121,296
Ensembl chr 7:132,113,433...132,121,294

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[allyl isothiocyanate results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]; Acetylcysteine inhibits the reaction [[Mustard Gas results in increased activity of TRPA1 protein] which results in increased uptake of Calcium]

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325

G

transient receptor potential cation channel, subfamily C, member 7

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRPC7 mRNA

NCBI chr17:7,707,954...7,839,064
Ensembl chr17:7,714,505...7,838,745

G

TSC complex subunit 2

multiple interactions

EXP

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of TSC2 protein]

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600

G

thyroid stimulating hormone subunit beta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [TSHB protein results in increased abundance of Hydrogen Peroxide]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

thymic stromal lymphopoietin

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of TSLP mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of TSLP mRNA]

PMID:18049884 PMID:29753051

NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420

G

tetraspanin 6

decreases expression

ISO

Acetylcysteine results in decreased expression of TSPAN6 mRNA

NCBI chr X:101,385,686...101,395,371
Ensembl chr X:101,385,694...101,392,627

G

tetratricopeptide repeat domain 7B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TTC7B mRNA

NCBI chr 6:125,317,011...125,528,843
Ensembl chr 6:125,316,789...125,528,779

G

tetratricopeptide repeat domain 9B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TTC9B mRNA

NCBI chr 1:92,081,026...92,083,208
Ensembl chr 1:92,080,806...92,083,203

G

tubulin, beta 3 class III

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA]

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

thioredoxin 1

multiple interactions
decreases expression

ISO

Acetylcysteine inhibits the reaction [arsenic trioxide results in decreased expression of TXN protein]; Acetylcysteine inhibits the reaction [Rotenone inhibits the reaction [TXN protein binds to and results in decreased activity of MAP3K5 protein]]
Acetylcysteine results in decreased expression of TXN protein
Acetylcysteine inhibits the reaction [Acrolein results in increased oxidation of TXN protein]; Acetylcysteine inhibits the reaction [indole-3-carbinol results in decreased expression of TXN protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]; Acetylcysteine inhibits the reaction [NCX 4040 results in increased oxidation of TXN1 protein]

PMID:16449798 PMID:17959236 PMID:18023956 PMID:18922898 PMID:24157283 More...

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of TXN2 mRNA]

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin domain containing 8

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TXNDC8 mRNA

NCBI chr 5:77,544,828...77,580,977
Ensembl chr 5:77,544,828...77,582,693

G

thioredoxin interacting protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TXNIP mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TXNIP protein]

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin-like 1

decreases expression

ISO

Acetylcysteine results in decreased expression of TXNL1 mRNA

NCBI chr18:59,397,275...59,428,072
Ensembl chr18:59,398,535...59,435,518

G

thioredoxin reductase 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thymidine phosphorylase

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[TYMP protein co-treated with Thymidine] results in increased expression of HMOX1 protein]

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003

G

tyrosinase

multiple interactions

ISO

[Acetylcysteine co-treated with 6-formylindolo(3,2-b)carbazole] results in increased activity of TYR protein; [Acetylcysteine co-treated with Benzo(a)pyrene] results in increased activity of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin-like modifier activating enzyme 7

increases expression
multiple interactions

ISO

Acetylcysteine results in increased expression of UBA7 protein
Acetylcysteine inhibits the reaction [Paraquat results in increased methylation of UBA7 mRNA]
Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; epigallocatechin gallate affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Resveratrol affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]

PMID:25649257 PMID:34425375

NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142

G

uncoupling protein 2

multiple interactions

EXP
ISO

Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of UCP2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of UCP2 protein]; Acetylcysteine inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of UCP2 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of UCP2 protein]

PMID:18183618 PMID:29061315 PMID:30104959 PMID:36493885

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

ubiquitin-fold modifier 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA]

NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:140,119,725...140,127,866

G

UDP-glucose 6-dehydrogenase

increases expression

ISO

Acetylcysteine results in increased expression of UGDH mRNA

NCBI chr14:43,202,480...43,226,002
Ensembl chr14:43,202,356...43,226,629

G

UDP glucuronosyltransferase family 1 member A6a

multiple interactions

EXP

Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA]; Acetylcysteine inhibits the reaction [Vitamin K 3 results in increased activity of UGT1A6 promoter]

PMID:15336321 PMID:22129741

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

ubiquitin-like with PHD and ring finger domains 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of UHRF1 mRNA

NCBI chr 9:1,220,162...1,241,792
Ensembl chr 9:1,222,063...1,241,792

G

unc-51 like autophagy activating kinase 1

multiple interactions

ISO

[1,12-benzoperylene co-treated with Acetylcysteine] results in increased expression of ULK1 mRNA; [Chloroquine co-treated with Acetylcysteine] results in decreased expression of ULK1 mRNA; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in decreased expression of and results in decreased phosphorylation of ULK1 protein]

PMID:27106530 PMID:33002460 PMID:39701484

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

G

ubiquitin specific peptidase like 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of USPL1 mRNA]

NCBI chr12:10,859,764...10,886,761
Ensembl chr12:10,859,764...10,886,744

G

UV radiation resistance associated

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of UVRAG mRNA]

NCBI chr 1:162,596,514...162,854,348
Ensembl chr 1:162,596,515...162,854,348

G

vascular cell adhesion molecule 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 protein]]
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

PMID:12615669 PMID:19281832 PMID:19642688 PMID:25876056 PMID:26901245 More...

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

voltage-dependent anion channel 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [3-monochloropropane-1, 2 diol ester results in increased expression of VDAC1 protein]; Acetylcysteine inhibits the reaction [[mono-(2-ethylhexyl)phthalate co-treated with Carbonyl Cyanide m-Chlorophenyl Hydrazone] results in increased degradation of VDAC1 protein]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of VDAC1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 protein]; Acetylcysteine inhibits the reaction [quinocetone promotes the reaction [VDAC1 protein binds to VDAC1 protein]]; Acetylcysteine inhibits the reaction [quinocetone results in increased expression of VDAC1 protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of VDAC1 protein]

PMID:22858589 PMID:23711929 PMID:28343033 PMID:33161305 PMID:38408632

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

voltage-dependent anion channel 2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [quinocetone promotes the reaction [VDAC2 protein binds to VDAC2 protein]]

NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,512,216...2,532,229

G

vascular endothelial growth factor A

decreases secretion
multiple interactions
decreases expression

ISO
EXP

Acetylcysteine results in decreased secretion of VEGFA protein
Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]
Acetylcysteine inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
Acetylcysteine results in decreased expression of VEGFA mRNA
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in decreased expression of VEGFA protein]; Acetylcysteine inhibits the reaction [[Peanut Oil results in increased abundance of Particulate Matter] which results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Hydrogen Peroxide] results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA mRNA]; Acetylcysteine inhibits the reaction [EGF protein results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [Glucose results in increased expression of VEGFA protein]; Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of VEGFA protein]; Acetylcysteine promotes the reaction [ginsenoside Rg3 inhibits the reaction [Glucose results in increased expression of VEGFA protein]]

PMID:11214823 PMID:11641398 PMID:11886167 PMID:13679210 PMID:15788408 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vascular endothelial growth factor B

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VEGFB mRNA

NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152

G

vimentin

multiple interactions
decreases expression

ISO

Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VIM protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VIM mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of VIM protein]; Acetylcysteine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of VIM protein]; Acetylcysteine inhibits the reaction [propiconazole results in increased expression of VIM protein]
Acetylcysteine results in decreased expression of VIM protein
Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of VIM protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of VIM protein]; Acetylcysteine inhibits the reaction [SHC1 protein results in increased expression of VIM protein]

PMID:28284859 PMID:32659284 PMID:32687844 PMID:33131013 PMID:34170130 More...

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vacuolar ATPase assembly factor VMA21

multiple interactions

ISO

Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [Cadmium results in increased expression of VMA21 mRNA]]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of VMA21 mRNA]

NCBI chr X:154,536,493...154,545,794
Ensembl chr X:154,536,493...154,545,794

G

vitelline membrane outer layer 1 homolog

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of VMO1 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of VMO1 mRNA]

NCBI chr10:55,726,572...55,733,432
Ensembl chr10:55,726,572...55,727,856

G

vacuole membrane protein 1

multiple interactions

ISO

[Chloroquine co-treated with Acetylcysteine] results in decreased expression of VMP1 mRNA

NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319

G

vanin 1

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of VNN1 mRNA

NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629

G

Wnt family member 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [quinocetone results in decreased expression of WNT1 protein]

NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:131,817,558...131,821,605

G

WT1 associated protein

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of WTAP protein]

NCBI chr 1:50,070,973...50,096,074
Ensembl chr 1:50,070,769...50,096,072

G

X-box binding protein 1

increases splicing
multiple interactions

ISO
EXP

Acetylcysteine results in increased splicing of XBP1 mRNA
Acetylcysteine inhibits the reaction [cinnamaldehyde inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [Doxorubicin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased splicing of XBP1 mRNA]; Acetylcysteine inhibits the reaction [shikonin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [toxoflavin inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]]; Acetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]]
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein alternative form]
Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of XBP1 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA]

PMID:19722195 PMID:21138464 PMID:21145380 PMID:21911445 PMID:25451595 More...

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

xanthine dehydrogenase

multiple interactions

ISO

[MPO protein co-treated with XDH protein co-treated with Acetaldehyde] promotes the reaction [Serotonin binds to Acetylcysteine]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-linked inhibitor of apoptosis

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[Bortezomib co-treated with Butyrates] results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with vorinostat] results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein]

PMID:15173093 PMID:19679660 PMID:21310227 PMID:22578287

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

X-ray repair cross complementing 1

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of XRCC1 mRNA]
Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in decreased abundance of Adenosine Triphosphate]; Acetylcysteine inhibits the reaction [XRCC1 gene mutant form results in increased abundance of Malondialdehyde]; Acetylcysteine promotes the reaction [XRCC1 protein results in decreased abundance of Malondialdehyde]; Acetylcysteine promotes the reaction [XRCC1 protein results in decreased oxidation of Glutathione]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased abundance of Adenosine Triphosphate]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased activity of CAT protein]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of CYTB mRNA]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND2 mRNA]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased expression of ND5 mRNA]

PMID:18948301 PMID:30998386

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

G

X-ray repair cross complementing 3

multiple interactions

ISO

Acetylcysteine inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of XRCC3 mRNA]

NCBI chr 6:136,684,558...136,694,822
Ensembl chr 6:136,684,558...136,694,822

G

X-ray repair cross complementing 6

multiple interactions

EXP

Acetylcysteine promotes the reaction [Acrylonitrile results in increased expression of XRCC6 mRNA]

NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:115,422,662...115,443,884

G

YTH N6-methyladenosine RNA binding protein F2

multiple interactions

ISO

Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [YTHDF2 protein binds to PTEN mRNA]]

NCBI chr 5:149,665,467...149,693,127
Ensembl chr 5:149,665,325...149,689,941

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

multiple interactions

ISO

Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to CTNNB1 protein]]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol inhibits the reaction [YWHAH protein binds to GSK3B protein]]

NCBI chr14:81,920,819...81,930,202
Ensembl chr14:81,920,590...81,947,930

G

YY1 transcription factor

multiple interactions

ISO

Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]

NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257

G

zinc finger and BTB domain containing 16

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZBTB16 mRNA

NCBI chr 8:57,885,886...58,073,507
Ensembl chr 8:57,891,081...58,073,507

G

zinc finger DHHC-type palmitoyltransferase 19

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZDHHC19 mRNA

NCBI chr11:81,782,899...81,794,105
Ensembl chr11:81,782,903...81,794,008

G

zinc finger AN1-type containing 2A

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZFAND2A mRNA]

NCBI chr12:20,275,435...20,286,513
Ensembl chr12:20,275,450...20,286,513

G

zinc finger homeobox 4

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZFHX4 mRNA

NCBI chr 2:98,131,996...98,321,070
Ensembl chr 2:98,131,996...98,315,469

G

zinc finger protein 36, C3H type-like 2

increases expression

ISO

Acetylcysteine results in increased expression of ZFP36L2 mRNA

NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:16,242,610...16,246,653

G

zinc finger protein 394

multiple interactions

ISO

Acetylcysteine inhibits the reaction [elesclomol results in increased expression of ZNF394 mRNA]

NCBI chr12:14,522,820...14,530,998

G

zinc finger protein 395

multiple interactions

EXP

[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ZFP395 mRNA

NCBI chr15:43,757,350...43,797,513
Ensembl chr15:43,757,473...43,797,512

G

zinc finger MYM-type containing 2

decreases expression

ISO

Acetylcysteine results in decreased expression of ZMYM2 mRNA

NCBI chr15:35,151,356...35,224,528
Ensembl chr15:35,127,994...35,224,941

N-acetylneuraminic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytidine monophosphate N-acetylneuraminic acid synthetase

affects abundance

ISO

CMAS protein affects the abundance of N-Acetylneuraminic Acid; CMAS protein affects the abundance of N-Acetylneuraminic Acid analog

NCBI chr 4:177,449,801...177,468,117
Ensembl chr 4:177,449,732...177,476,291

G

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

increases chemical synthesis

EXP

GNE protein results in increased chemical synthesis of N-Acetylneuraminic Acid

NCBI chr 5:63,062,953...63,103,320
Ensembl chr 5:63,062,850...63,103,251

G

N-acetylneuraminate synthase

increases chemical synthesis

ISO

NANS results in increased chemical synthesis of N-Acetylneuraminic Acid

NCBI chr 5:65,575,970...65,593,164
Ensembl chr 5:65,576,015...65,610,547

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

EXP

Nevirapine results in increased expression of ABCB1A mRNA

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ADAM metallopeptidase with thrombospondin type 1 motif, 15

increases expression

ISO

Nevirapine results in increased expression of ADAMTS15 mRNA

NCBI chr 8:37,566,064...37,589,446
Ensembl chr 8:37,566,065...37,589,446

G

ADAM metallopeptidase with thrombospondin type 1 motif, 9

decreases expression

EXP

Nevirapine metabolite results in decreased expression of ADAMTS9 mRNA; Nevirapine results in decreased expression of ADAMTS9 mRNA

NCBI chr 4:126,847,726...127,019,924
Ensembl chr 4:126,847,729...127,019,876

G

adhesion G protein-coupled receptor F5

increases expression

EXP

Nevirapine metabolite results in increased expression of ADGRF5 mRNA

NCBI chr 9:25,014,861...25,128,045
Ensembl chr 9:25,018,277...25,121,237

G

adiponectin, C1Q and collagen domain containing

increases expression
increases secretion

ISO

Nevirapine results in increased expression of ADIPOQ mRNA
Nevirapine results in increased secretion of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adrenoceptor beta 2

increases expression

ISO

Nevirapine results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

allograft inflammatory factor 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of AIF1 mRNA

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

5'-aminolevulinate synthase 1

increases expression

ISO

Nevirapine results in increased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

albumin

affects binding

ISO

Nevirapine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

apolipoprotein A1

increases expression

ISO

Nevirapine results in increased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

androgen receptor

increases expression

ISO

Nevirapine results in increased expression of AR mRNA; Nevirapine results in increased expression of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

armadillo repeat containing, X-linked 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of ARMCX2 mRNA; Nevirapine results in decreased expression of ARMCX2 mRNA

NCBI chr X:102,273,915...102,278,789
Ensembl chr X:102,273,565...102,278,905

G

aryl hydrocarbon receptor nuclear translocator

increases expression

EXP

Nevirapine metabolite results in increased expression of ARNT mRNA

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

arrestin domain containing 3

decreases expression

ISO

Nevirapine results in decreased expression of ARRDC3 mRNA

NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875

G

ATPase Na+/K+ transporting subunit beta 1

increases expression

ISO

Nevirapine results in increased expression of ATP1B1 mRNA

NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549

G

bone morphogenetic protein 6

increases expression

ISO

Nevirapine results in increased expression of BMP6 mRNA

NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,523,704...26,675,261

G

caspase 3

increases cleavage
multiple interactions

ISO

Nevirapine results in increased cleavage of CASP3 protein
Mifepristone inhibits the reaction [Nevirapine results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

CD180 molecule

decreases expression

ISO

Nevirapine results in decreased expression of CD180 mRNA

NCBI chr 2:35,589,889...35,602,837
Ensembl chr 2:35,589,451...35,603,982

G

CD36 molecule

increases expression

EXP

Nevirapine metabolite results in increased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Nevirapine results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CCAAT/enhancer binding protein alpha

increases expression

ISO

Nevirapine results in increased expression of CEBPA mRNA

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

carboxylesterase 2H

increases expression

EXP

Nevirapine results in increased expression of CES2 mRNA

NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752

G

class II, major histocompatibility complex, transactivator

increases expression

ISO

Nevirapine results in increased expression of CIITA

NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,647,085...5,694,342

G

cytokine inducible SH2-containing protein

decreases expression

ISO

Nevirapine results in decreased expression of CISH mRNA

NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:116,850,773...116,855,986

G

claudin 5

decreases expression

ISO

Nevirapine results in decreased expression of CLDN5 mRNA

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

C-type lectin domain family 4, member A1

decreases expression

EXP

Nevirapine results in decreased expression of CLEC4A1 mRNA

NCBI chr 4:157,845,811...157,857,926
Ensembl chr 4:157,845,752...157,858,273

G

C-type lectin domain family 4, member A3

decreases expression

EXP

Nevirapine results in decreased expression of CLEC4A3 mRNA

NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:157,885,895...157,896,727

G

C-type lectin domain family 4 member M

increases expression

EXP

Nevirapine metabolite results in increased expression of CD209B mRNA

NCBI chr12:6,713,795...6,722,414
Ensembl chr12:6,713,812...6,722,410

G

coactosin-like F-actin binding protein 1

decreases expression

EXP

Nevirapine results in decreased expression of COTL1 mRNA

NCBI chr19:64,780,309...64,814,629
Ensembl chr19:64,780,322...64,814,840

G

cut-like homeobox 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of CUX2 mRNA

NCBI chr12:40,168,402...40,368,303
Ensembl chr12:40,149,292...40,366,528

G

C-X-C motif chemokine ligand 3

decreases expression

ISO

Nevirapine results in decreased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

EXP

Nevirapine metabolite results in increased expression of CYP2B1 mRNA; Nevirapine results in increased expression of CYP2B1 mRNA

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression

ISO

[Nevirapine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Nevirapine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
Nevirapine results in increased expression of CYP2B10 mRNA

PMID:17041008 PMID:38636494

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

affects binding

EXP

Nevirapine binds to CYP2C11 protein

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects binding
decreases activity

ISO

Nevirapine binds to CYP3A4 protein
Nevirapine results in decreased activity of CYP3A4 protein

PMID:22793666 PMID:39023798

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

affects binding
increases expression

EXP

Nevirapine binds to CYP3A23-3A1 protein
Nevirapine results in increased expression of CYP3A23-3A1 mRNA

PMID:22793666 PMID:23947594

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression

EXP

Nevirapine results in increased expression of CYP3A9 mRNA

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

EXP

Nevirapine metabolite results in increased expression of CYP4B1 mRNA

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

death associated protein kinase 1

increases expression

EXP

Nevirapine metabolite results in increased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

D-box binding PAR bZIP transcription factor

decreases expression

EXP

Nevirapine metabolite results in decreased expression of DBP mRNA

NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:105,312,108...105,317,205

G

doublecortin-like kinase 3

decreases expression

ISO

Nevirapine results in decreased expression of DCLK3 mRNA

NCBI chr 8:120,279,916...120,332,362
Ensembl chr 8:120,279,757...120,332,432

G

DDHD domain containing 1

decreases expression

EXP

Nevirapine results in decreased expression of DDHD1 mRNA

NCBI chr15:21,304,053...21,370,608
Ensembl chr15:21,303,826...21,370,608

G

DNA-damage-inducible transcript 4

increases expression

ISO

Nevirapine results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

DEP domain containing 7

decreases expression

ISO

Nevirapine results in decreased expression of DEPDC7 mRNA

NCBI chr 3:111,554,701...111,575,979
Ensembl chr 3:111,554,706...111,575,979

G

disco-interacting protein 2 homolog A

increases expression

EXP

Nevirapine results in increased expression of DIP2A mRNA

NCBI chr20:12,284,037...12,373,519
Ensembl chr20:12,284,038...12,370,532

G

DnaJ heat shock protein family (Hsp40) member B5

increases expression

EXP

Nevirapine metabolite results in increased expression of DNAJB5 mRNA

NCBI chr 5:61,972,637...61,981,887
Ensembl chr 5:61,972,706...61,981,860

G

dual specificity phosphatase 1

increases expression

ISO

Nevirapine results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

EXP

Nevirapine results in increased expression of EDEM1 mRNA

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

epidermal growth factor

decreases expression

ISO

Nevirapine results in decreased expression of EGF mRNA

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

decreases expression

ISO

Nevirapine results in decreased expression of EGFR mRNA

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

erythrocyte membrane protein band 4.1-like 3

decreases expression

EXP

Nevirapine results in decreased expression of EPB41L3 mRNA

NCBI chr 9:116,502,864...116,707,274
Ensembl chr 9:116,462,807...116,707,274

G

epiregulin

increases expression

ISO

Nevirapine results in increased expression of EREG mRNA

NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260

G

endothelial cell-specific molecule 1

increases expression

EXP

Nevirapine metabolite results in increased expression of ESM1 mRNA; Nevirapine results in increased expression of ESM1 mRNA

NCBI chr 2:46,609,253...46,617,991
Ensembl chr 2:46,609,204...46,617,990

G

family with sequence similarity 107, member A

increases expression

EXP

Nevirapine results in increased expression of FAM107A mRNA

NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219

G

fin bud initiation factor homolog

increases expression

EXP

Nevirapine results in increased expression of FIBIN mRNA

NCBI chr 3:117,396,973...117,399,244
Ensembl chr 3:117,391,724...117,399,479

G

FKBP prolyl isomerase 5

increases expression

EXP

Nevirapine metabolite results in increased expression of FKBP5 mRNA; Nevirapine results in increased expression of FKBP5 mRNA

NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of FMO1 mRNA

NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874

G

forkhead box O1

increases expression

ISO

Nevirapine results in increased expression of FOXO1 mRNA

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

growth arrest and DNA-damage-inducible, beta

increases expression

EXP
ISO

Nevirapine results in increased expression of GADD45B mRNA

PMID:23947594 PMID:38636494

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

growth differentiation factor 15

multiple interactions
increases expression

ISO

Nevirapine results in increased expression of and results in increased secretion of GDF15 protein
Nevirapine results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glutamate-ammonia ligase

decreases expression

EXP

Nevirapine metabolite results in decreased expression of GLUL mRNA

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glutamic--pyruvic transaminase

multiple interactions

ISO

Mifepristone inhibits the reaction [Nevirapine results in increased secretion of and results in increased activity of GPT protein]; Nevirapine results in increased secretion of and results in increased activity of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione S-transferase alpha 1

increases glutathionylation

ISO

GSTA1 protein results in increased glutathionylation of Nevirapine metabolite

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase mu 1

increases glutathionylation

ISO

GSTM1 protein results in increased glutathionylation of Nevirapine metabolite

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase pi 1

increases glutathionylation

ISO

GSTP1 protein results in increased glutathionylation of Nevirapine metabolite

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

granzyme A

decreases expression

EXP

Nevirapine metabolite results in decreased expression of GZMA mRNA

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

granzyme F

decreases expression

EXP

Nevirapine metabolite results in decreased expression of GZMF mRNA

NCBI chr15:33,975,543...33,997,505
Ensembl chr15:33,977,505...33,997,572

G

hydroxyacid oxidase 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of HAO2 mRNA; Nevirapine results in decreased expression of HAO2 mRNA

NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133

G

histidine decarboxylase

decreases expression

EXP

Nevirapine metabolite results in decreased expression of HDC mRNA

NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:134,300,632...134,318,711

G

hepatocyte growth factor

decreases secretion

ISO

Nevirapine results in decreased secretion of HGF protein

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

increases expression

EXP

Nevirapine metabolite results in increased expression of HMGCS2 mRNA; Nevirapine results in increased expression of HMGCS2 mRNA

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242

G

15-hydroxyprostaglandin dehydrogenase

increases expression

EXP

Nevirapine metabolite results in increased expression of HPGD mRNA

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831

G

hydroxysteroid (17-beta) dehydrogenase 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of HSD17B2 mRNA

NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943

G

heat shock protein family A (Hsp70) member 2

increases expression

ISO

Nevirapine results in increased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

interferon gamma

increases expression

ISO
EXP

Nevirapine results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor binding protein 1

increases expression
multiple interactions

ISO

Nevirapine results in increased expression of IGFBP1 mRNA
Nevirapine results in increased expression of and results in increased secretion of IGFBP1 protein

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

immunoglobulin heavy chain 6

increases expression

EXP

Nevirapine results in increased expression of IGH-6 mRNA

G

interferon gamma induced GTPase

decreases expression

EXP

Nevirapine results in decreased expression of IGTP mRNA

NCBI chr10:42,875,047...42,882,866
Ensembl chr10:42,876,790...42,882,858

G

Indian hedgehog signaling molecule

decreases expression

ISO

Nevirapine results in decreased expression of IHH mRNA

NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:83,952,986...83,959,203

G

interleukin 1 beta

increases expression

ISO

Nevirapine results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

increases expression

ISO

Nevirapine results in increased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 22 receptor subunit alpha 2

increases expression

EXP

Nevirapine metabolite results in increased expression of IL22RA2 mRNA

NCBI chr 1:16,172,238...16,228,009
Ensembl chr 1:16,184,113...16,197,950

G

interleukin 24

increases expression

ISO

Nevirapine results in increased expression of IL24 mRNA

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

interleukin 6

decreases secretion

ISO

Nevirapine results in decreased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibin subunit beta E

decreases expression

EXP
ISO

Nevirapine metabolite results in decreased expression of INHBE mRNA
Nevirapine results in decreased expression of INHBE mRNA

PMID:23947594 PMID:38636494

NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519

G

indolethylamine N-methyltransferase

increases expression

EXP

Nevirapine results in increased expression of INMT mRNA

NCBI chr 4:85,648,459...85,652,755
Ensembl chr 4:85,648,459...85,652,755

G

insulin induced gene 2

increases expression

EXP

Nevirapine results in increased expression of INSIG2 mRNA

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

interferon regulatory factor 1

decreases expression

ISO

Nevirapine results in decreased expression of IRF1 mRNA

NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947

G

immunity-related GTPase M

decreases expression

EXP

Nevirapine results in decreased expression of IRGM mRNA

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,732,961...33,743,228

G

insulin receptor substrate 3

decreases expression

EXP

Nevirapine metabolite results in decreased expression of IRS3 mRNA; Nevirapine results in decreased expression of IRS3 mRNA

NCBI chr12:24,689,930...24,692,068
Ensembl chr12:24,689,909...24,692,068

G

integrin subunit alpha 2

increases expression

ISO

Nevirapine results in increased expression of ITGA2 mRNA

NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression

EXP

Nevirapine results in increased expression of ITPR1 mRNA

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Nevirapine results in increased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

KLF transcription factor 15

increases expression

EXP

Nevirapine metabolite results in increased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

kallikrein 1-related peptidase C10

increases expression

ISO

Nevirapine results in increased expression of KLK3 mRNA; Nevirapine results in increased expression of KLK3 protein

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

keratin 18

increases expression

ISO

Nevirapine results in increased expression of KRT18 protein

NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848

G

keratin 23

increases expression

EXP

Nevirapine metabolite results in increased expression of KRT23 mRNA

NCBI chr10:84,930,603...84,946,929
Ensembl chr10:84,930,603...84,946,929

G

lecithin cholesterol acyltransferase

increases expression

ISO

Nevirapine results in increased expression of LCAT protein

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

lipocalin 2

increases expression

ISO

Nevirapine results in increased expression of LCN2 mRNA

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lipid droplet assembly factor 1

decreases expression

EXP

Nevirapine results in decreased expression of LDAF1 mRNA

NCBI chr 1:183,915,919...183,934,374
Ensembl chr 1:183,849,812...183,934,666

G

leptin

increases expression

ISO

Nevirapine results in increased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

LHFPL tetraspan subfamily member 2

decreases expression

ISO

Nevirapine results in decreased expression of LHFPL2 mRNA

NCBI chr 2:27,016,404...27,169,830
Ensembl chr 2:27,016,700...27,162,859

G

LIF receptor subunit alpha

increases expression

EXP

Nevirapine metabolite results in increased expression of LIFR mRNA

NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364

G

lipase G, endothelial type

decreases expression

EXP

Nevirapine metabolite results in decreased expression of LIPG mRNA; Nevirapine results in decreased expression of LIPG mRNA

NCBI chr18:70,790,077...70,811,259
Ensembl chr18:70,790,077...70,812,260

G

lipin 1

increases expression

EXP

Nevirapine metabolite results in increased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

lipoprotein lipase

increases expression

ISO

Nevirapine results in increased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leucine-rich alpha-2-glycoprotein 1

increases expression

EXP

Nevirapine metabolite results in increased expression of LRG1 mRNA

NCBI chr 9:1,034,691...1,036,937
Ensembl chr 9:1,034,679...1,037,337

G

lymphocyte antigen 86

decreases expression

EXP

Nevirapine results in decreased expression of LY86 mRNA

NCBI chr17:27,621,313...27,705,336
Ensembl chr17:27,621,313...27,692,743

G

mesenchyme homeobox 2

increases expression

EXP

Nevirapine results in increased expression of MEOX2 mRNA

NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:59,583,785...59,644,700

G

MET proto-oncogene, receptor tyrosine kinase

increases expression

ISO

Nevirapine results in increased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

MFSD2 lysolipid transporter A, lysophospholipid

increases expression

ISO

Nevirapine results in increased expression of MFSD2A mRNA

NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916

G

matrix Gla protein

increases expression

EXP

Nevirapine results in increased expression of MGP mRNA

NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:171,497,471...171,500,859

G

mannose receptor, C type 1

increases expression

EXP

Nevirapine metabolite results in increased expression of MRC1 mRNA

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

membrane-spanning 4-domains, subfamily A, member 6B

increases expression

EXP

Nevirapine metabolite results in increased expression of MS4A6B mRNA

NCBI chr 1:217,705,785...217,727,719
Ensembl chr 1:217,705,961...217,727,450

G

membrane spanning 4-domains A7

decreases expression

EXP

Nevirapine results in decreased expression of MS4A7 mRNA

NCBI chr 1:217,394,019...217,409,643
Ensembl chr 1:217,394,019...217,409,643

G

nicotinamide phosphoribosyltransferase

increases expression

EXP

Nevirapine metabolite results in increased expression of NAMPT mRNA

NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544

G

NADH:ubiquinone oxidoreductase complex assembly factor 4

increases expression

EXP

Nevirapine results in increased expression of NDUFAF4 mRNA

NCBI chr 5:43,401,795...43,406,967

G

NLR family, CARD domain containing 5

increases expression

ISO

Nevirapine results in increased expression of NLRC5

NCBI chr19:10,483,601...10,587,223
Ensembl chr19:10,483,755...10,555,786

G

neuronal PAS domain protein 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of NPAS2 mRNA; Nevirapine results in decreased expression of NPAS2 mRNA

NCBI chr 9:48,959,225...49,138,036
Ensembl chr 9:48,959,148...49,138,037

G

neuronal pentraxin 2

increases expression

EXP

Nevirapine results in increased expression of NPTX2 mRNA

NCBI chr12:15,151,136...15,162,045
Ensembl chr12:15,151,136...15,162,045

G

nuclear receptor subfamily 1, group D, member 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of NR1D1 mRNA

NCBI chr10:84,224,599...84,231,812
Ensembl chr10:84,224,540...84,231,812

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

[Nevirapine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; [Nevirapine results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

neuronal regeneration related protein

decreases expression

EXP

Nevirapine metabolite results in decreased expression of NREP mRNA; Nevirapine results in decreased expression of NREP mRNA

NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742

G

oxidative stress induced growth inhibitor 1

decreases expression

ISO

Nevirapine results in decreased expression of OSGIN1 mRNA

NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162

G

purinergic receptor P2X 7

decreases expression

EXP

Nevirapine results in decreased expression of P2RX7 mRNA

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

Purkinje cell protein 4-like 1

decreases expression

EXP

Nevirapine results in decreased expression of PCP4L1 mRNA

NCBI chr13:86,121,463...86,145,097
Ensembl chr13:86,121,464...86,144,899

G

pyruvate dehydrogenase kinase 4

increases expression

EXP

Nevirapine metabolite results in increased expression of PDK4 mRNA

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

phosphotyrosine interaction domain containing 1

increases expression

ISO

Nevirapine results in increased expression of PID1 mRNA

NCBI chr 9:92,732,471...92,951,168
Ensembl chr 9:92,734,214...92,750,070

G

phosphoinositide-3-kinase interacting protein 1

increases expression

EXP

Nevirapine results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261
Ensembl chr14:82,428,248...82,440,260

G

Pim-3 proto-oncogene, serine/threonine kinase

increases expression

ISO

Nevirapine results in increased expression of PIM3 mRNA

NCBI chr 7:121,822,076...121,836,257
Ensembl chr 7:121,832,742...121,836,259

G

pirin

increases expression

EXP

Nevirapine metabolite results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

paired-Ig-like receptor A2

decreases expression

EXP

Nevirapine results in decreased expression of PIRA2 mRNA

NCBI chr 1:74,283,713...74,338,208

G

phospholipase A2, group XIIA

increases expression

ISO

Nevirapine results in increased expression of PLA2G12A mRNA

NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:221,110,685...221,126,964

G

perilipin 4

increases expression

ISO

Nevirapine results in increased expression of PLIN4 mRNA

NCBI chr 9:1,016,334...1,025,249
Ensembl chr 9:1,016,302...1,025,368

G

patatin-like phospholipase domain containing 2

increases expression

EXP

Nevirapine metabolite results in increased expression of PNPLA2 mRNA

NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:205,982,258...205,987,359

G

cytochrome p450 oxidoreductase

increases expression

EXP
ISO

Nevirapine metabolite results in increased expression of POR mRNA; Nevirapine results in increased expression of POR mRNA

PMID:23947594 PMID:38636494

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

Nevirapine results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

EXP

Nevirapine metabolite results in decreased expression of PPP2R2B mRNA; Nevirapine results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,904,686...35,356,977

G

perforin 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of PRF1 mRNA

NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124

G

pyrroline-5-carboxylate reductase 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of PYCR1 mRNA

NCBI chr10:106,416,056...106,420,982
Ensembl chr10:106,412,576...106,423,393

G

Rap guanine nucleotide exchange factor 4

increases expression

ISO

Nevirapine results in increased expression of RAPGEF4 mRNA

NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978

G

ras related dexamethasone induced 1

increases expression

ISO

Nevirapine results in increased expression of RASD1 mRNA

NCBI chr10:45,265,975...45,275,279
Ensembl chr10:45,265,979...45,267,710

G

RNA binding motif protein 3

increases expression

EXP

Nevirapine results in increased expression of RBM3 mRNA

NCBI chr X:17,020,863...17,024,341
Ensembl chr X:17,020,864...17,024,841

G

reticulophagy regulator 1

increases expression

EXP

Nevirapine metabolite results in increased expression of RETREG1 mRNA; Nevirapine results in increased expression of RETREG1 mRNA

NCBI chr 2:78,045,435...78,205,316
Ensembl chr 2:78,066,031...78,225,356

G

similar to RIKEN cDNA 3110043O21

increases expression

ISO

Nevirapine results in increased expression of C9ORF72 mRNA

NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:54,562,570...54,587,637

G

regulator of G-protein signaling 16

increases expression

ISO

Nevirapine results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

rhomboid domain containing 2

increases expression

EXP

Nevirapine results in increased expression of RHBDD2 mRNA

NCBI chr12:26,680,206...26,690,926
Ensembl chr12:26,680,969...26,691,080

G

Rho-related BTB domain containing 1

increases expression

ISO

Nevirapine results in increased expression of RHOBTB1 mRNA

NCBI chr20:19,326,197...19,455,182
Ensembl chr20:19,326,212...19,402,057

G

reprimo, TP53 dependent G2 arrest mediator homolog

decreases expression

EXP

Nevirapine metabolite results in decreased expression of RPRM mRNA

NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:58,799,866...58,950,542

G

S100 calcium binding protein A7A

increases expression

EXP

Nevirapine metabolite results in increased expression of S100A7A mRNA

NCBI chr 2:178,448,983...178,453,424
Ensembl chr 2:178,448,983...178,453,424

G

sterol carrier protein 2

increases expression

ISO

Nevirapine results in increased expression of SCP2

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

serum/glucocorticoid regulated kinase 1

increases expression

ISO

Nevirapine results in increased expression of SGK1 mRNA

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231

G

SLAM family member 9

decreases expression

EXP

Nevirapine results in decreased expression of SLAMF9 mRNA

NCBI chr13:87,474,290...87,477,108
Ensembl chr13:87,474,290...87,477,107

G

solute carrier family 25, member 51

increases expression

ISO

Nevirapine results in increased expression of SLC25A51 mRNA

NCBI chr 5:64,445,610...64,459,172
Ensembl chr 5:64,443,616...64,459,462

G

solute carrier family 34 member 2

decreases expression

EXP

Nevirapine metabolite results in decreased expression of SLC34A2 mRNA

NCBI chr14:62,123,313...62,153,020
Ensembl chr14:62,123,316...62,143,360

G

solute carrier family 38, member 2

increases expression

ISO

Nevirapine results in increased expression of SLC38A2 mRNA

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 5 member 5

multiple interactions

ISO

[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

solute carrier family 7 member 11

increases expression

ISO

Nevirapine results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

sterol regulatory element binding transcription factor 1

increases expression
decreases expression

ISO
EXP

Nevirapine results in increased expression of SREBF1 mRNA
Nevirapine metabolite results in decreased expression of SREBF1 mRNA

PMID:21619898 PMID:23947594

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sulfotransferase family 1A member 1

increases activity

EXP

Nevirapine metabolite results in increased activity of SULT1A1 protein; Nevirapine results in increased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

tyrosine aminotransferase

increases expression

ISO

Nevirapine results in increased expression of TAT mRNA

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

thyroglobulin

increases expression

ISO

Nevirapine results in increased expression of TG mRNA; Nevirapine results in increased expression of TG protein

NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539

G

transforming growth factor, beta 3

increases expression

ISO

Nevirapine results in increased expression of TGFB3 mRNA

NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946

G

transmembrane protein 64

increases expression

EXP

Nevirapine metabolite results in increased expression of TMEM64 mRNA; Nevirapine results in increased expression of TMEM64 mRNA

NCBI chr 5:33,495,992...33,542,390
Ensembl chr 5:33,496,032...33,542,389

G

TNF alpha induced protein 6

increases expression

ISO

Nevirapine results in increased expression of TNFAIP6 mRNA

NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796

G

TNF receptor superfamily member 1B

increases expression

ISO

Nevirapine results in increased expression of TNFRSF1B mRNA

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TOX high mobility group box family member 3

increases expression

EXP

Nevirapine results in increased expression of TOX3 mRNA

NCBI chr19:32,820,957...32,929,776
Ensembl chr19:32,820,977...32,929,776

G

thyroid peroxidase

increases expression

ISO

Nevirapine results in increased expression of TPO mRNA; Nevirapine results in increased expression of TPO protein

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

tripartite motif-containing 24

decreases expression

EXP

Nevirapine results in decreased expression of TRIM24 mRNA

NCBI chr 4:67,534,240...67,659,014
Ensembl chr 4:67,534,335...67,684,226

G

tripartite motif containing 63

increases expression

EXP

Nevirapine metabolite results in increased expression of TRIM63 mRNA

NCBI chr 5:151,817,209...151,831,026
Ensembl chr 5:151,817,225...151,831,058

G

TSC22 domain family, member 3

increases expression

EXP

Nevirapine results in increased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

thyroid stimulating hormone subunit beta

multiple interactions

ISO

[Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 mRNA; [Nevirapine co-treated with TSHB protein] results in increased expression of SLC5A5 protein; Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

thyroid stimulating hormone receptor

increases expression

ISO

Nevirapine results in increased expression of TSHR mRNA

NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010

G

tsukushi, small leucine rich proteoglycan

increases expression

EXP

Nevirapine results in increased expression of TSKU mRNA

NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272

G

uncoupling protein 1

increases expression

ISO

Nevirapine results in increased expression of UCP1

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

uncoupling protein 3

increases expression

EXP

Nevirapine metabolite results in increased expression of UCP3 mRNA

NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:164,227,882...164,241,210

G

vascular cell adhesion molecule 1

increases expression

EXP

Nevirapine metabolite results in increased expression of VCAM1 mRNA

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

decreases expression

ISO

Nevirapine results in decreased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

visinin-like 1

decreases expression

EXP

Nevirapine metabolite results in decreased expression of VSNL1 mRNA; Nevirapine results in decreased expression of VSNL1 mRNA

NCBI chr 6:39,757,721...39,878,556
Ensembl chr 6:39,757,722...39,878,556

G

zeta chain of T cell receptor associated protein kinase 70

increases expression

EXP

Nevirapine results in increased expression of ZAP70 mRNA

NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:46,485,598...46,509,062

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

ISO

Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

carboxylesterase 1D

affects hydrolysis
increases metabolic processing
multiple interactions

ISO

CES1 protein affects the hydrolysis of Oseltamivir
CES1 protein results in increased metabolism of Oseltamivir
7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]

PMID:18983829 PMID:35278473 PMID:37716419

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

interleukin 6

decreases response to substance

ISO

IL6 protein results in decreased susceptibility to Oseltamivir

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

progesterone receptor

multiple interactions

ISO

Oseltamivir binds to and results in increased activity of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

solute carrier family 7 member 11

decreases expression

ISO

Oseltamivir results in decreased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

phosphonoformic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

Foscarnet inhibits the reaction [Phosphates results in decreased expression of AKT1 mRNA]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

dentin matrix acidic phosphoprotein 1

multiple interactions

ISO

Foscarnet inhibits the reaction [Phosphates results in increased expression of DMP1 mRNA]

NCBI chr14:5,833,111...5,867,154
Ensembl chr14:5,833,111...5,843,993

G

phosphate regulating endopeptidase X-linked

multiple interactions

ISO

Foscarnet inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA]

NCBI chr X:41,422,561...41,671,226
Ensembl chr X:41,426,101...41,671,226

G

solute carrier family 16 member 1

multiple interactions
increases import

EXP

Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]
SLC16A1 protein results in increased import of Foscarnet

PMID:10579682 PMID:10714609

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 20 member 1

decreases activity
multiple interactions
increases expression

ISO
EXP

Foscarnet results in decreased activity of SLC20A1 protein
Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A1 mRNA]
Foscarnet results in increased expression of SLC20A1 mRNA

PMID:15641067 PMID:17438129 PMID:23308213

NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:136,880,290...136,894,249

G

solute carrier family 20 member 2

multiple interactions

ISO

Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC20A2 mRNA]

NCBI chr16:76,163,315...76,253,881
Ensembl chr16:76,162,922...76,253,881

G

solute carrier family 23 member 2

multiple interactions

ISO

Foscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]

NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343

G

secreted phosphoprotein 1

multiple interactions

ISO

Foscarnet inhibits the reaction [Calcium results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 mRNA]; Foscarnet inhibits the reaction [Phosphates results in increased expression of SPP1 protein]

PMID:12788230 PMID:17383965 PMID:18412142

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

stanniocalcin 1

increases expression

EXP

Foscarnet results in increased expression of STC1 mRNA

NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

increases hydrolysis

ISO

ACHE protein results in increased hydrolysis of remdesivir

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

ATM serine/threonine kinase

increases phosphorylation

ISO

remdesivir results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

remdesivir results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

increases hydrolysis

ISO

BCHE protein results in increased hydrolysis of remdesivir

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

decreases expression

ISO

remdesivir results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 11

increases expression

ISO

remdesivir results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

caspase 3

decreases expression

ISO

remdesivir results in decreased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

decreases expression

ISO

remdesivir results in decreased expression of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

C-C motif chemokine ligand 2

decreases expression

ISO

Remdesivir decreases expression of CCL2 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells

RGD

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

caudal type homeo box 2

increases expression

ISO

remdesivir results in increased expression of CDX2 mRNA

NCBI chr12:12,762,769...12,769,246
Ensembl chr12:12,762,904...12,769,246

G

carboxylesterase 1D

multiple interactions
increases hydrolysis

ISO

Simvastatin inhibits the reaction [CES1 protein results in increased hydrolysis of remdesivir]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

cathepsin A

increases hydrolysis

ISO

CTSA protein results in increased hydrolysis of remdesivir

NCBI chr 3:173,988,443...173,994,320
Ensembl chr 3:173,988,460...173,995,539

G

C-X-C motif chemokine ligand 10

decreases expression

ISO

Remdesivir decreases expression of CXCL10 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells

RGD

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

estrogen-related receptor beta

decreases expression

ISO

remdesivir results in decreased expression of ESRRB mRNA

NCBI chr 6:111,738,662...111,894,087
Ensembl chr 6:111,738,662...111,894,087

G

forkhead box O3

increases expression

ISO

remdesivir results in increased expression of FOXO3 protein

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

GATA binding protein 3

increases expression

ISO

remdesivir results in increased expression of GATA3 mRNA

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670

G

GATA binding protein 4

decreases expression

ISO

remdesivir results in decreased expression of GATA4 mRNA

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

H2A.X variant histone

increases expression

ISO

remdesivir results in increased expression of H2AX protein

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

interleukin 1 beta

decreases expression

ISO

Remdesivir decreases expression of IL1B mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells

RGD

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

decreases expression

ISO

Remdesivir decreases expression of IL-6 mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells

RGD

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

marker of proliferation Ki-67

decreases expression

ISO

remdesivir results in decreased expression of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

Nanog homeobox

decreases expression

ISO

remdesivir results in decreased expression of NANOG mRNA

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

poly (ADP-ribose) polymerase 1

increases expression

ISO

remdesivir results in increased expression of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

platelet derived growth factor receptor alpha

decreases expression

ISO

remdesivir results in decreased expression of PDGFRA mRNA

NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516

G

SRY-box transcription factor 17

decreases expression

ISO

remdesivir results in decreased expression of SOX17 mRNA

NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:19,814,360...19,819,854

G

SRY-box transcription factor 2

decreases expression

ISO

remdesivir results in decreased expression of SOX2 mRNA

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

tumor necrosis factor

decreases expression

ISO

Remdesivir decreases expression of TNF mRNA and protein in SARS-CoV-2 induced hepatocellular carcinoma cells

RGD

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

ISO

Ritonavir results in decreased activity of ABCB11 protein
Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613 More...

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily B member 4

decreases expression
decreases activity

ISO

Ritonavir results in decreased expression of ABCB4
Ritonavir results in decreased activity of ABCB4 protein

PMID:26626330 PMID:28437613

NCBI chr 4:26,106,895...26,164,440

G

ATP binding cassette subfamily C member 3

decreases activity

ISO

Ritonavir results in decreased activity of ABCC3 protein

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

decreases activity

ISO

Ritonavir results in decreased activity of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

acyl-CoA synthetase short-chain family member 2

affects expression

EXP

Ritonavir affects the expression of ACSS2 mRNA

NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

ISO

Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein
rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein]
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]

PMID:15865214 PMID:17668557

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

AKT serine/threonine kinase 1

increases phosphorylation

ISO

Ritonavir results in increased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

affects binding

ISO

Ritonavir binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

BCL2-antagonist/killer 1

increases expression

ISO

Ritonavir results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2, apoptosis regulator

decreases expression

ISO

Ritonavir results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

decreases expression

ISO

Ritonavir results in decreased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein

PMID:16174765 PMID:21270666

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 1

decreases expression

ISO

Ritonavir results in decreased expression of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

decreases activity

ISO

Ritonavir results in decreased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

multiple interactions
increases expression
increases secretion
decreases expression

ISO

diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
Ritonavir results in decreased expression of CCL2

PMID:17668557 PMID:20884875 PMID:26626330

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 20

decreases expression

ISO

Ritonavir results in decreased expression of CCL20

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

C-C motif chemokine ligand 3

decreases expression
increases expression

ISO

Ritonavir results in decreased expression of CCL3
Ritonavir results in increased expression of CCL3 protein

PMID:17668557 PMID:26626330

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

decreases expression

ISO

Ritonavir results in decreased expression of CCL4

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

cyclin A2

decreases expression

ISO

Ritonavir results in decreased expression of CCNA2 mRNA

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

Ritonavir results in decreased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

decreases expression

ISO

Ritonavir results in decreased expression of CCND1 protein

PMID:16551874 PMID:21270666

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

decreases expression

ISO

Ritonavir results in decreased expression of CCND2 mRNA

PMID:16174765 PMID:19386116

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E2

decreases expression

ISO

Ritonavir results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882

G

cyclin dependent kinase 2

decreases expression

ISO

Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein

PMID:16551874 PMID:19386116

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

decreases expression

ISO

Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein

PMID:16551874 PMID:19386116

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5

decreases expression

ISO

Ritonavir results in decreased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 6

decreases expression

ISO

Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein

PMID:16551874 PMID:19386116

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]

PMID:19386116 PMID:20884875

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

Ritonavir results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2B

increases expression

ISO

Ritonavir results in increased expression of CDKN2B mRNA

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

CCAAT/enhancer binding protein alpha

multiple interactions

ISO

Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

class II, major histocompatibility complex, transactivator

increases expression

ISO

Ritonavir results in increased expression of CIITA

NCBI chr10:5,646,854...5,694,393
Ensembl chr10:5,647,085...5,694,342

G

carnitine O-octanoyltransferase

decreases expression

EXP

Ritonavir results in decreased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:26,052,516...26,088,064

G

C-X-C motif chemokine ligand 1

decreases expression

ISO

Ritonavir results in decreased expression of CXCL1

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

decreases expression

ISO

Ritonavir results in decreased expression of CXCL10

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

decreases expression

ISO

Ritonavir results in decreased expression of CXCL12

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

decreases expression

ISO

Ritonavir results in decreased expression of CXCL2

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

decreases expression

ISO

Ritonavir results in decreased expression of CXCL1

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine ligand 6

decreases expression

ISO

Ritonavir results in decreased expression of CXCL6

NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,594,959...17,596,417

G

cytochrome b5 reductase 3

affects expression

EXP

Ritonavir affects the expression of CYB5R3 mRNA

NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:116,186,729...116,204,306

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

ISO

Ritonavir results in increased expression of CYP1A1 mRNA
Ritonavir results in decreased activity of CYP1A1 protein

PMID:11918509 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases expression

ISO
EXP

Ritonavir results in increased expression of CYP1A2 mRNA
Ritonavir results in decreased expression of CYP1A2 mRNA

PMID:11918509 PMID:17719200

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

Ritonavir results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity
increases expression

ISO

Ritonavir results in increased activity of CYP2B6 protein
Ritonavir results in increased expression of CYP2B6 protein

PMID:14977870 PMID:26626330

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

ISO

Ritonavir results in increased expression of CYP2C19 mRNA

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

ISO

Ritonavir results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing

ISO

CYP2D6 protein affects the metabolism of Ritonavir

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
decreases activity
affects binding
affects metabolic processing

ISO

Ritonavir results in increased expression of CYP3A4 mRNA
Ritonavir results in decreased activity of CYP3A4 protein
CYP3A4 protein binds to Ritonavir analog
CYP3A4 protein affects the metabolism of Ritonavir

PMID:15286053 PMID:15523003 PMID:15860655 PMID:16837568 PMID:26626330 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

EXP

Ritonavir results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases activity

ISO

Ritonavir results in decreased activity of CYP3A5 protein

NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression

EXP

Ritonavir results in decreased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytochrome P450, family 4, subfamily b, polypeptide 1

affects expression
decreases expression

EXP

Ritonavir affects the expression of CYP4B1 mRNA
Ritonavir results in decreased expression of CYP4B1 mRNA

NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116

G

cytochrome P450, family 51

increases expression

EXP

Ritonavir results in increased expression of CYP51 mRNA

NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

ISO
EXP

Ritonavir results in decreased expression of CYP7A1 mRNA

PMID:17719200 PMID:26626330

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

ISO
EXP

Ritonavir results in decreased expression of CYP8B1
Ritonavir results in decreased expression of CYP8B1 mRNA

PMID:17719200 PMID:26626330

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689

G

7-dehydrocholesterol reductase

affects expression

EXP

Ritonavir affects the expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

E2F transcription factor 1

decreases expression

ISO

Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 2

decreases expression

ISO

Ritonavir results in decreased expression of E2F2 mRNA

NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:153,682,789...153,706,087

G

E2F transcription factor 3

decreases expression

ISO

Ritonavir results in decreased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

EXP

Ritonavir affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

estrogen receptor 1

decreases expression

ISO

Ritonavir results in decreased expression of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

Fas ligand

decreases expression

ISO

Ritonavir results in decreased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

affects expression

EXP

Ritonavir affects the expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 19

increases expression

ISO

Ritonavir results in increased expression of FGF19 mRNA

NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:209,485,813...209,490,267

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Ritonavir results in increased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

galactosidase, beta 1

multiple interactions
increases activity

ISO

Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

glycerol-3-phosphate dehydrogenase 1

multiple interactions

ISO

Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]

NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368

G

heme oxygenase 1

multiple interactions
increases expression

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein]
Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein

PMID:15504750 PMID:26968795

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein 90 alpha family class A member 1

affects response to substance

ISO

HSP90AA1 protein affects the susceptibility to Ritonavir

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein family H (Hsp110) member 1

increases expression

ISO

Ritonavir results in increased expression of HSPH1 protein

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

intercellular adhesion molecule 1

increases expression
multiple interactions

ISO

Ritonavir results in increased expression of ICAM1 protein
HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 6

multiple interactions
increases expression
increases secretion

ISO

diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]
Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein

PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7

decreases expression

ISO

Ritonavir results in decreased expression of IL7

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

insulin 1

multiple interactions

ISO

Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

Ritonavir results in increased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

leptin

multiple interactions
decreases expression

ISO

diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein]

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

LIF, interleukin 6 family cytokine

decreases expression

ISO

Ritonavir results in decreased expression of LIF

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:83,358,164...83,364,053

G

lamin A/C

increases expression
increases farnesylation

ISO

Ritonavir results in increased expression of LMNA protein
Ritonavir results in increased farnesylation of LMNA protein alternative form

PMID:18230615 PMID:20884875

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:176,237,564...176,288,072

G

lipoprotein lipase

affects expression

ISO

Ritonavir affects the expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

Ritonavir results in decreased expression of MYC mRNA

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

ISO

Ritonavir results in increased expression of NFE2L2 protein
NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

decreases activity

ISO

Ritonavir results in decreased activity of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

decreases phosphorylation

ISO

Ritonavir results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NLR family, CARD domain containing 5

decreases expression

ISO

Ritonavir results in decreased expression of NLRC5

NCBI chr19:10,483,601...10,587,223
Ensembl chr19:10,483,755...10,555,786

G

nitric oxide synthase 3

multiple interactions
decreases expression

ISO

Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 4

decreases expression
multiple interactions

EXP

Ritonavir results in decreased expression of NOTCH4 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

Ritonavir increases expression of NR1H3 mRNA in macrophages

RGD

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group H, member 4

increases expression

ISO

Ritonavir results in increased expression of NR1H4 mRNA

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity

ISO
EXP

Ritonavir binds to and results in increased activity of NR1I2 protein
Ritonavir results in increased activity of NR1I2 protein

PMID:14977870 PMID:15849716 PMID:27732639

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Ritonavir results in increased cleavage of PARP1 protein

PMID:19386116 PMID:21270666

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

paraoxonase 1

decreases activity

EXP

Ritonavir results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]
Ritonavir results in increased expression of PPARG mRNA

PMID:11101056 PMID:17879945

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase C, alpha

multiple interactions
increases activity
increases expression

ISO

Ritonavir binds to and affects the localization of PRKCA protein
Ritonavir results in increased activity of PRKCA protein
Ritonavir results in increased expression of PRKCA protein

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

proteasome 20S subunit alpha 1

affects expression

EXP

Ritonavir affects the expression of PSMA1 mRNA

NCBI chr 1:177,876,838...177,887,857
Ensembl chr 1:177,875,353...177,887,949

G

proteasome 20S subunit beta 3

affects expression

EXP

Ritonavir affects the expression of PSMB3 mRNA

NCBI chr10:83,193,787...83,200,883
Ensembl chr10:83,193,787...83,200,883

G

proteasome 20S subunit beta 5

increases expression

EXP

Ritonavir results in increased expression of PSMB5 mRNA

NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379

G

RB transcriptional corepressor 1

decreases phosphorylation
increases expression

ISO

Ritonavir results in decreased phosphorylation of RB1 protein
Ritonavir results in increased expression of RB1 mRNA

PMID:16551874 PMID:19386116 PMID:21270666

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RB transcriptional corepressor like 1

increases expression

ISO

Ritonavir results in increased expression of RBL1 mRNA

NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:166,226,198...166,289,376

G

RB transcriptional corepressor like 2

decreases expression

ISO

Ritonavir results in decreased expression of RBL2 mRNA

NCBI chr19:32,049,690...32,096,467
Ensembl chr19:32,049,691...32,096,411

G

REL proto-oncogene, NF-kB subunit

decreases activity

ISO

Ritonavir results in decreased activity of REL protein

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

decreases activity

ISO

Ritonavir results in decreased activity of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

scavenger receptor class B, member 1

multiple interactions
increases expression

ISO

Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]
Ritonavir results in increased expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sterol carrier protein 2

decreases expression

ISO

Ritonavir results in decreased expression of SCP2

NCBI chr 5:128,035,714...128,110,015
Ensembl chr 5:128,008,125...128,110,043

G

solute carrier family 10 member 1

decreases expression

ISO

Ritonavir results in decreased expression of SLC10A1

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

solute carrier family 51 member A

decreases expression

ISO

Ritonavir results in decreased expression of SLC51A

NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539

G

solute carrier organic anion transporter family member 1B2

decreases activity

ISO

Ritonavir results in decreased activity of SLCO1B3 protein

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

solute carrier organic anion transporter family, member 4C1

multiple interactions

ISO

Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid]

NCBI chr 9:104,624,802...104,676,462
Ensembl chr 9:104,624,802...104,676,462

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

ISO

Ritonavir results in decreased phosphorylation of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein]

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

Ritonavir results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tight junction protein 1

decreases expression
multiple interactions

EXP

Ritonavir results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

decreases secretion
multiple interactions
increases expression

ISO

Ritonavir results in decreased secretion of TNF protein
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA]
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein

PMID:10551732 PMID:15388451 PMID:15865214

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]

PMID:19386116 PMID:20884875

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A1

affects expression

ISO

Ritonavir affects the expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

zinc metallopeptidase STE24

decreases activity

ISO

Ritonavir results in decreased activity of ZMPSTE24 protein

NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:139,913,671...139,945,532

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

ISO

Saquinavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Saquinavir results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101 PMID:24014644

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 1A

increases export
affects uptake
affects export

ISO

ABCB1 protein results in increased export of Saquinavir
ABCB1A protein affects the uptake of Saquinavir
ABCB1 protein affects the export of Saquinavir

PMID:10562306 PMID:15832500 PMID:18535159

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

affects uptake

ISO

ABCB1B protein affects the uptake of Saquinavir

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily C member 1

increases export

ISO

ABCC1 protein results in increased export of Saquinavir

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions
increases export

ISO

ABCC2 protein affects the export of Saquinavir
montelukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]

PMID:15832500 PMID:18535159 PMID:19952419

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

ISO

Saquinavir results in decreased expression of ADIPOQ mRNA; Saquinavir results in decreased expression of ADIPOQ protein
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA; rosiglitazone inhibits the reaction [Saquinavir results in decreased secretion of ADIPOQ protein]

PMID:15865214 PMID:16931933

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

AE binding protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA

NCBI chr14:84,951,577...84,962,840
Ensembl chr14:84,952,822...84,962,843

G

albumin

affects binding

ISO

Saquinavir binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

cAMP regulated phosphoprotein 21

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA

NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:120,912,970...121,031,357

G

acid sensing ion channel subunit 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA

NCBI chr10:66,368,308...67,438,237
Ensembl chr10:66,368,310...66,636,245

G

activating transcription factor 6

increases expression

ISO

Saquinavir results in increased expression of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

complement C1r

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA

NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:159,098,918...159,109,714

G

complement C3a receptor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA

NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:157,746,089...157,776,323

G

caspase 9

increases cleavage

ISO

Saquinavir results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

CD36 molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142

G

complement factor D

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:10,463,775...10,465,572

G

cell death-inducing DFFA-like effector c

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:148,124,925...148,137,806

G

chloride voltage-gated channel 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA

NCBI chr16:34,138,004...34,210,984
Ensembl chr16:34,137,952...34,210,984

G

cytochrome b-245 beta chain

multiple interactions

ISO

Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

ISO

Saquinavir results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity
increases metabolic processing

ISO

Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]
CYP3A4 protein results in increased metabolism of Saquinavir

PMID:11824416 PMID:15523003

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

decorin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

dual specificity phosphatase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA

NCBI chr10:87,420,213...87,434,202
Ensembl chr10:87,419,494...87,434,063

G

ELOVL fatty acid elongase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA

NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559

G

estrogen receptor 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

ETS variant transcription factor 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802

G

fatty acid desaturase 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

Fas apoptotic inhibitory molecule

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA

NCBI chr 8:108,423,259...108,445,365
Ensembl chr 8:108,423,221...108,440,151

G

G0/G1switch 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

glucosidase, alpha; neutral C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA

NCBI chr 3:127,807,132...127,858,995
Ensembl chr 3:127,807,441...127,859,859

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987

G

H4 clustered histone 8

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA

NCBI chr17:47,176,246...47,180,690
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr17:41,797,152...41,806,539
Ensembl chr 4:41,797,152...41,806,539

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA

NCBI chr 2:222,462,049...222,504,446
Ensembl chr 2:222,462,049...222,504,446

G

hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA

NCBI chr 2:51,228,710...51,632,806
Ensembl chr 2:51,228,710...51,632,806

G

heat shock protein family A (Hsp70) member 5

increases expression

ISO

Saquinavir results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

IKAROS family zinc finger 4

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA

NCBI chr 7:1,643,379...1,687,524
Ensembl chr 7:1,644,799...1,687,094

G

interleukin 6

increases expression
multiple interactions

ISO

Saquinavir results in increased expression of IL6 mRNA; Saquinavir results in increased expression of IL6 protein
rosiglitazone inhibits the reaction [Saquinavir results in increased expression of IL6 mRNA]
Saquinavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

PMID:15388451 PMID:15865214

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 2

multiple interactions

ISO

Saquinavir inhibits the reaction [INS protein results in increased import of Glucose]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

kelch-like family member 28

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA

NCBI chr 6:88,723,624...88,755,072
Ensembl chr 6:88,727,205...88,752,457

G

laminin subunit gamma 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA

NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102

G

lymphoid enhancer binding factor 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

leptin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

lipoprotein lipase

decreases activity
decreases expression

ISO

Saquinavir results in decreased activity of LPL protein
Saquinavir results in decreased expression of LPL mRNA

PMID:11741158 PMID:11786383

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

malic enzyme 1

decreases expression

ISO

Saquinavir results in decreased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

MGAT4 family, member C

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA

NCBI chr 7:38,596,117...39,361,103
Ensembl chr 7:38,596,065...39,362,078

G

melanocortin 2 receptor accessory protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA

NCBI chr11:43,477,382...43,489,118
Ensembl chr11:43,478,001...43,489,118

G

myogenic differentiation 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

nucleosome assembly protein 1-like 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA

NCBI chr 4:89,352,834...89,354,704
Ensembl chr 4:89,351,926...89,361,736

G

nocturnin

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA

NCBI chr 2:137,422,074...137,442,282
Ensembl chr 2:137,422,074...137,442,282

G

notch receptor 4

multiple interactions
decreases expression

EXP

[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
Saquinavir results in decreased expression of NOTCH4 protein

NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,161,730...4,189,072

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

ISO

NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Saquinavir]

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nucleoporin 210

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA

NCBI chr 4:125,068,736...125,167,238
Ensembl chr 4:125,068,736...125,167,047

G

ornithine decarboxylase antizyme 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA

NCBI chr 2:184,762,242...184,765,176
Ensembl chr 2:184,762,245...184,771,428

G

protocadherin related 15

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA

NCBI chr20:13,996,383...15,495,206
Ensembl chr20:13,999,116...15,493,958

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

PHD finger protein 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA

NCBI chr X:137,576,214...137,619,297
Ensembl chr X:137,576,235...137,615,914

G

p53-induced death domain protein 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

piwi-like RNA-mediated gene silencing 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA

NCBI chr15:51,841,104...51,907,729
Ensembl chr15:51,841,405...51,907,819

G

paraoxonase 1

decreases activity

EXP

Saquinavir results in decreased activity of PON1 protein

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

porcupine O-acyltransferase

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA

NCBI chr X:16,957,811...16,970,440
Ensembl chr X:16,957,810...16,970,439

G

POU class 5 homeobox 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

PR/SET domain 1

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

receptor accessory protein 6

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA

NCBI chr 7:10,024,601...10,031,507
Ensembl chr 7:10,024,602...10,031,740

G

ring finger protein 151

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA

NCBI chr10:14,247,215...14,251,738
Ensembl chr10:14,247,215...14,251,204

G

RPA interacting protein

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA

NCBI chr10:56,190,975...56,198,490
Ensembl chr10:56,190,967...56,199,685

G

RT1 class I, locus CE5

affects expression

ISO

Saquinavir affects the expression of HLA-F mRNA

NCBI chr20:3,407,880...3,484,130

G

RT1 class II, locus DOa

affects expression

ISO

Saquinavir affects the expression of HLA-DOA mRNA

NCBI chr20:4,755,287...4,758,491
Ensembl chr20:4,755,499...4,758,478

G

S100 calcium binding protein A8

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

solute carrier organic anion transporter family, member 1a4

affects uptake

ISO

SLCO1A2 protein affects the uptake of Saquinavir

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

superoxide dismutase 2

multiple interactions

ISO

Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

serine peptidase inhibitor, Kazal type 5

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA

NCBI chr18:36,515,347...36,584,038
Ensembl chr18:36,515,347...36,583,799

G

synaptic vesicle glycoprotein 2b

affects response to substance

ISO

SV2B gene SNP affects the susceptibility to Saquinavir

NCBI chr 1:138,388,268...138,562,635
Ensembl chr 1:138,388,266...138,562,258

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

tight junction protein 1

multiple interactions
decreases expression

EXP

[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]
Saquinavir results in decreased expression of TJP1 protein

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

multiple interactions
increases expression

ISO

Saquinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Saquinavir results in increased expression of TNF mRNA; Saquinavir results in increased expression of TNF protein
rosiglitazone inhibits the reaction [Saquinavir results in increased expression of TNF mRNA]

PMID:15388451 PMID:15865214

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tripartite motif-containing 42

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA

NCBI chr 8:106,781,847...106,802,764
Ensembl chr 8:106,781,851...106,802,764

G

Wnt family member 10A

multiple interactions

ISO

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA

NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin G1

decreases expression

EXP

roscovitine decreases expression of Ccng1 in rat brain injury lesions

RGD

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin-dependent kinase 1

decreases activity

EXP

Roscovitine decreases activity of Cdk1 protein in oocytes

RGD

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

increases expression

EXP

roscovitine (seliciclib) increases expression of mRNA inhibiting the reaction [camptothecin increases kinase activity] in rat cerebellar granule neurons

RGD

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 6

increases expression

EXP

roscovitine (seliciclib) increases expression of mRNA inhibiting the reaction [camptothecin increases kinase activity] in rat cerebellar granule neurons

RGD

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

killer cell lectin like receptor C1

decreases expression

ISO

sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells

RGD

NCBI chr 4:164,828,163...164,838,446
Ensembl chr 4:164,828,163...164,838,464

G

natural cytotoxicity triggering receptor 1

affects expression

ISO

sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells

RGD

NCBI chr 1:78,657,409...78,665,255
Ensembl chr 1:78,659,262...78,703,273

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin]

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin-related polypeptide, beta

increases expression

EXP

Telbivudine results in increased expression of CALCB mRNA

NCBI chr 1:178,399,634...178,404,654
Ensembl chr 1:178,399,785...178,404,654

G

CCAAT/enhancer binding protein beta

increases expression

EXP

Telbivudine results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

C-type lectin domain family 2, member G

increases expression

EXP

Telbivudine results in increased expression of CLEC2G mRNA

NCBI chr 4:164,303,865...164,313,737
Ensembl chr 4:164,300,076...164,314,591

G

DEAD box helicase 3, Y-linked

increases expression

EXP

Telbivudine results in increased expression of DDX3Y mRNA

NCBI chr Y:1,190,042...1,210,699
Ensembl chr Y:1,191,242...1,210,650

G

lysine demethylase 5D

increases expression

EXP

Telbivudine results in increased expression of KDM5D mRNA

NCBI chr Y:551,621...647,742
Ensembl chr Y:564,261...660,970

G

melanocortin 2 receptor

decreases expression

EXP

Telbivudine results in decreased expression of MC2R mRNA

NCBI chr18:64,279,878...64,291,775
Ensembl chr18:64,277,360...64,291,881

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

ISO

Telbivudine results in decreased expression of COX2 protein

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrial amidoxime reducing component 1

decreases expression

EXP

Telbivudine results in decreased expression of MTARC1 mRNA

NCBI chr13:98,854,235...98,894,208
Ensembl chr13:98,871,289...98,894,252

G

NADH:ubiquinone oxidoreductase subunit B8

decreases expression

ISO

Telbivudine results in decreased expression of NDUFB8 protein

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:253,357,841...253,362,936

G

phosphoenolpyruvate carboxykinase 1

decreases expression

EXP

Telbivudine results in decreased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

tenofovir disoproxil fumarate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Tenofovir results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

acetyl-CoA carboxylase beta

affects expression

ISO

Tenofovir affects the expression of ACACB mRNA

NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214

G

BCL2 interacting protein 3 like

increases expression

ISO

Tenofovir results in increased expression of BNIP3L protein

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

caspase 3

multiple interactions
increases expression

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of CASP3 protein]; Tenofovir results in increased expression of and results in increased activity of CASP3 protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of CASP3 protein]
Tenofovir results in increased expression of CASP3 mRNA

PMID:33146023 PMID:36309141

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions
increases expression

EXP

Melatonin inhibits the reaction [Tenofovir results in increased expression of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 20

increases expression
multiple interactions

ISO

Tenofovir results in increased expression of CCL20 mRNA
Tenofovir results in increased expression of and results in increased secretion of CCL20 protein

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

[Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein
Tenofovir results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

Tenofovir results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

DEAD box helicase 3, Y-linked

increases expression

EXP

Tenofovir results in increased expression of DDX3Y mRNA

NCBI chr Y:1,190,042...1,210,699
Ensembl chr Y:1,191,242...1,210,650

G

endothelin 1

increases secretion
multiple interactions

ISO

Tenofovir results in increased secretion of EDN1 protein
coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

eukaryotic translation initiation factor 2 subunit alpha

affects phosphorylation

ISO

Tenofovir affects the phosphorylation of EIF2S1 protein

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

fibrinogen beta chain

decreases expression

EXP

Tenofovir results in decreased expression of FGB mRNA

NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:170,692,965...170,705,434

G

gap junction protein, gamma 2

increases expression

EXP

Tenofovir results in increased expression of GJC2 mRNA

NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340

G

hepatitis A virus cellular receptor 1

increases secretion
multiple interactions

ISO

Tenofovir results in increased secretion of HAVCR1 protein
Tenofovir inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

heme oxygenase 1

decreases expression
multiple interactions

EXP

Tenofovir results in decreased expression of HMOX1 protein
Melatonin inhibits the reaction [Tenofovir results in decreased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid 11-beta dehydrogenase 1

affects expression

ISO

Tenofovir affects the expression of HSD11B1 mRNA

NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432

G

heat shock protein family D (Hsp60) member 1

affects expression

ISO

Tenofovir affects the expression of HSPD1 protein

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

interleukin 1 beta

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interferon regulatory factor 4

decreases expression

EXP

Tenofovir results in decreased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730

G

lysine demethylase 5D

increases expression

EXP

Tenofovir results in increased expression of KDM5D mRNA

NCBI chr Y:551,621...647,742
Ensembl chr Y:564,261...660,970

G

KLF transcription factor 15

decreases expression

EXP

Tenofovir results in decreased expression of KLF15 mRNA

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:124,522,909...124,542,373

G

lipase E, hormone sensitive type

affects expression

ISO

Tenofovir affects the expression of LIPE mRNA

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117

G

lon peptidase 1, mitochondrial

affects expression

ISO

Tenofovir affects the expression of LONP1 protein

NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427

G

lipin 1

decreases expression

EXP

Tenofovir results in decreased expression of LPIN1 mRNA

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

mitogen-activated protein kinase 8

affects phosphorylation

ISO

Tenofovir affects the phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

myeloperoxidase

multiple interactions

EXP

[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

ISO

Tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

NFKB inhibitor alpha

decreases expression

EXP

Tenofovir results in decreased expression of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

increases expression
multiple interactions

EXP

Tenofovir results in increased expression of NOS2 mRNA; Tenofovir results in increased expression of NOS2 protein
Melatonin inhibits the reaction [Tenofovir results in increased expression of NOS2 protein]

PMID:27899301 PMID:33146023

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions
decreases phosphorylation

ISO

coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

nuclear receptor subfamily 3, group C, member 1

affects expression

ISO

Tenofovir affects the expression of NR3C1 mRNA

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

5' nucleotidase, ecto

increases expression

ISO

Tenofovir results in increased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

5',3'-nucleotidase, mitochondrial

decreases expression

ISO

Tenofovir results in decreased expression of NT5M mRNA

NCBI chr10:45,151,902...45,178,687
Ensembl chr10:45,152,505...45,181,308

G

2'-5' oligoadenylate synthetase-like 2

increases expression

EXP

Tenofovir results in increased expression of OASL2 mRNA

NCBI chr12:47,369,829...47,383,337
Ensembl chr12:47,370,028...47,383,185

G

olfactory receptor family 8 subfamily B member 53

decreases expression

EXP

Tenofovir results in decreased expression of OR8B53 mRNA

NCBI chr 8:47,780,882...47,781,829
Ensembl chr 8:47,780,882...47,781,829

G

poly (ADP-ribose) polymerase 1

increases expression
multiple interactions

EXP

Tenofovir results in increased expression of PARP1 protein
Melatonin inhibits the reaction [Tenofovir results in increased expression of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxisome proliferator-activated receptor gamma

affects expression

ISO

Tenofovir affects the expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

ISO

[Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

prostaglandin-endoperoxide synthase 2

increases expression

EXP

Tenofovir results in increased expression of PTGS2 mRNA; Tenofovir results in increased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization
increases expression

EXP

Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]; Tenofovir results in increased expression of and results in increased activity of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sirtuin 3

increases expression

ISO

Tenofovir results in increased expression of SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

solute carrier family 22 member 6

increases response to substance
increases import
multiple interactions

ISO

SLC22A6 protein results in increased susceptibility to Tenofovir
SLC22A6 protein results in increased import of Tenofovir
Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]

PMID:23856525 PMID:25448811 PMID:29738843

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 22 member 8

increases response to substance
increases import

ISO

SLC22A8 protein results in increased susceptibility to Tenofovir
SLC22A8 protein results in increased import of Tenofovir

PMID:25448811 PMID:29738843

NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588

G

tumor necrosis factor

decreases expression
multiple interactions
increases expression

ISO
EXP

Tenofovir results in decreased expression of TNF mRNA
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein; Zinc inhibits the reaction [[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased expression of TNF protein]
Tenofovir results in increased expression of TNF mRNA; Tenofovir results in increased expression of TNF protein

PMID:24205323 PMID:27899301 PMID:36309141

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

[Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein
Tenofovir results in increased expression of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

ubiquitin specific peptidase 18

increases expression

EXP

Tenofovir results in increased expression of USP18 mRNA

NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:156,143,815...156,171,292

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

ISO

tipranavir results in decreased activity of ABCB11 protein
tipranavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

PMID:24014644 PMID:28437613

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

tipranavir results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

ISO

CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CASP3 protein]; Trifluridine results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases cleavage

ISO

Trifluridine results in increased cleavage of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases cleavage

ISO

Trifluridine results in increased cleavage of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cathepsin B

increases cleavage
multiple interactions

ISO

Trifluridine results in increased cleavage of CTSB protein
CA 074 methyl ester inhibits the reaction [Trifluridine results in increased cleavage of CTSB protein]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

estrogen receptor 2

multiple interactions

ISO

Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

estrogen related receptor, alpha

multiple interactions

ISO

Trifluridine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]

NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811

G

NFE2 like bZIP transcription factor 2

increases activity

ISO

Trifluridine results in increased activity of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

ISO

Trifluridine results in increased activity of NR1I2 protein
[Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

Trifluridine inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Trifluridine results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

tumor protein p53

affects activity

ISO

Trifluridine affects the activity of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

biphenyl hydrolase like

increases hydrolysis

ISO

BPHL protein results in increased hydrolysis of Valganciclovir

NCBI chr17:31,006,283...31,042,631
Ensembl chr17:31,004,972...31,042,632

G

solute carrier family 15 member 1

increases transport
multiple interactions

ISO

SLC15A1 protein results in increased transport of Valganciclovir
Valganciclovir inhibits the reaction [SLC15A1 protein results in increased transport of glycylsarcosine]

NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369

G

solute carrier family 15 member 2

multiple interactions

EXP

Valganciclovir inhibits the reaction [SLC15A2 protein results in increased transport of glycylsarcosine]

NCBI chr11:77,519,565...77,548,609
Ensembl chr11:77,519,529...77,548,606

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

affects phosphorylation

EXP

Zalcitabine affects the phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

affects binding

ISO

Zalcitabine binds to ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

anoctamin 3

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ANO3 mRNA

NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:117,692,103...118,004,675

G

apurinic/apyrimidinic endodeoxyribonuclease 1

increases response to substance

ISO

APEX1 protein mutant form results in increased susceptibility to Zalcitabine

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

aryl hydrocarbon receptor nuclear translocator 2

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ARNT2 mRNA

NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:147,599,058...147,801,997

G

ATPase plasma membrane Ca2+ transporting 4

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of ATP2B4 mRNA

NCBI chr13:47,708,157...47,807,389
Ensembl chr13:47,711,121...47,758,876

G

bromodomain PHD finger transcription factor

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of BPTF mRNA

NCBI chr10:92,480,007...92,582,485
Ensembl chr10:92,480,007...92,582,413

G

similar to human chromosome 17 open reading frame 75

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of C10H17ORF75 mRNA

NCBI chr10:65,855,926...65,871,711
Ensembl chr10:65,858,774...65,874,883

G

C-C motif chemokine ligand 2

increases expression

EXP

Zalcitabine results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-X-C motif chemokine ligand 12

increases expression

EXP

Zalcitabine results in increased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine receptor 4

increases expression

EXP

Zalcitabine results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

deoxycytidine kinase

affects response to substance

ISO

DCK protein affects the susceptibility to Zalcitabine

NCBI chr14:19,589,298...19,610,326
Ensembl chr14:19,589,298...19,610,326

G

DEP domain containing 1B

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of DEPDC1B mRNA

NCBI chr 2:41,605,686...41,697,207
Ensembl chr 2:41,624,922...41,697,202

G

discs large MAGUK scaffold protein 5

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA

NCBI chr15:125,287...237,334
Ensembl chr15:125,290...237,332

G

estrogen-related receptor gamma

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of ESRRG mRNA

NCBI chr13:101,699,043...102,316,877
Ensembl chr13:101,889,706...102,316,877

G

family with sequence similarity 81, member A

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FAM81A mRNA

NCBI chr 8:79,643,754...79,702,792
Ensembl chr 8:79,644,516...79,702,767

G

fucose-1-phosphate guanylyltransferase

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of FPGT mRNA

NCBI chr 2:246,757,982...246,778,896
Ensembl chr 2:246,757,986...246,778,848

G

galactosidase, alpha

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of GLA mRNA

NCBI chr X:102,062,497...102,073,915
Ensembl chr X:102,056,718...102,073,915

G

5-hydroxytryptamine receptor 2A

increases response to substance
increases expression
multiple interactions

ISO
EXP

HTR2A gene results in increased susceptibility to Zalcitabine
Zalcitabine results in increased expression of HTR2A protein
[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine

NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619

G

interleukin 2 receptor subunit alpha

decreases expression
multiple interactions

ISO

Zalcitabine results in decreased expression of IL2RA mRNA; Zalcitabine results in decreased expression of IL2RA protein
Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interferon regulatory factor 7

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

kinesin family member 5A

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNA

NCBI chr 7:64,937,210...64,974,339
Ensembl chr 7:64,934,740...64,978,272

G

laminin subunit alpha 5

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNA

NCBI chr 3:187,647,904...187,695,974
Ensembl chr 3:187,647,904...187,696,173

G

leucine zipper protein 2

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of LUZP2 mRNA

NCBI chr 1:114,733,026...115,119,374
Ensembl chr 1:114,733,455...115,119,630

G

midnolin

multiple interactions

EXP

[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of MIDN mRNA

NCBI chr 7:10,198,761...10,210,563
Ensembl chr 7:10,200,306...10,207,203

G

mitochondrially encoded cytochrome c oxidase I

decreases expression
multiple interactions

ISO

Zalcitabine results in decreased expression of COX1 protein
Uridine inhibits the reaction [Zalcitabine results in decreased expression of COX1 protein]

PMID:17187420 PMID:18823003 PMID:20032772

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

EXP

Zalcitabine results in decreased expression of COX2 mRNA

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrially encoded cytochrome c oxidase III

decreases expression

ISO

Zalcitabine results in decreased expression of COX3 protein

NCBI chr MT:8,599...9,382
Ensembl chr MT:8,584...9,367