CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: trans-stilbene-4,4'-diol
Accession: CHEBI:36012
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Definition: A stilbene-4,4'-diol that has formula C14H12O2.
Synonyms: exact_synonym: 4,4'-[(1E)-ethene-1,2-diyl]diphenol
related_synonym: 4,4'-(E)-ethene-1,2-diyldiphenol; Formula=C14H12O2; InChI=1S/C14H12O2/c15-13-7-3-11(4-8-13)1-2-12-5-9-14(16)10-6-12/h1-10,15-16H/b2-1+; InChIKey=XLAIWHIOIFKLEO-OWOJBTEDSA-N; SMILES=Oc1ccc(cc1)\\C=C\\c1ccc(O)cc1
xref: Beilstein:2048565; CAS:659-22-3; Gmelin:2250544; KEGG:C14233
xref_mesh: MESH:C010118
G
Ar
androgen receptor
affects binding
EXP
4,4'-dihydroxystilbene binds to AR protein
CTD
PMID:14565775
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Ccna2
cyclin A2
increases expression
ISO
4,4'-dihydroxystilbene results in increased expression of CCNA2 mRNA
CTD
PMID:19496085
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ctsd
cathepsin D
increases expression
ISO
4,4'-dihydroxystilbene results in increased expression of CTSD mRNA
CTD
PMID:19496085
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Ece1
endothelin converting enzyme 1
decreases activity decreases expression
ISO
4,4'-dihydroxystilbene results in decreased activity of ECE1 protein 4,4'-dihydroxystilbene results in decreased expression of ECE1 mRNA
CTD
PMID:21554123
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
G
Edn1
endothelin 1
decreases secretion decreases expression
ISO
4,4'-dihydroxystilbene results in decreased secretion of EDN1 protein 4,4'-dihydroxystilbene results in decreased expression of EDN1 mRNA
CTD
PMID:21554123
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Esr1
estrogen receptor 1
multiple interactions
ISO
4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein]
CTD
PMID:19496085
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
4,4'-dihydroxystilbene results in increased expression of FOS mRNA
CTD
PMID:19496085
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Pgr
progesterone receptor
increases expression
ISO
4,4'-dihydroxystilbene results in increased expression of PGR mRNA
CTD
PMID:19496085
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Shbg
sex hormone binding globulin
affects binding
ISO
4,4'-dihydroxystilbene binds to SHBG protein
CTD
PMID:25349334
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
G
Tff1
trefoil factor 1
increases expression
ISO
4,4'-dihydroxystilbene results in increased expression of TFF1 mRNA
CTD
PMID:19496085
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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