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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chicoric acid
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Accession:CHEBI:3594 term browser browse the term
Definition:An organooxygen compound that has formula C22H18O12.
Synonyms:exact_synonym: (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid
 related_synonym: Formula=C22H18O12;   InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1;   InChIKey=YDDGKXBLOXEEMN-IABMMNSOSA-N;   SMILES=OC(=O)[C@H](OC(=O)\\C=C\\C1=CC=C(O)C(O)=C1)[C@@H](OC(=O)\\C=C\\C1=CC=C(O)C(O)=C1)C(O)=O;   dicaffeoyltartaric acid
 xref: CAS:70831-56-0;   FooDB:FDB012144;   HMDB:HMDB0002375;   KEGG:C10437;   KNApSAcK:C00002723
 xref_mesh: MESH:C100435
 xref: PDBeChem:GKP;   PMID:24244361;   PMID:30251662;   PMID:8692814;   Wikipedia:Cichoric_acid


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chicoric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation EXP chicoric acid results in increased phosphorylation of ACACA protein CTD PMID:24244361 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:24244361 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cs citrate synthase increases activity EXP chicoric acid results in increased activity of CS protein CTD PMID:24244361 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP chicoric acid inhibits the reaction [INS1 protein results in increased phosphorylation of MTOR protein] CTD PMID:24244361 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP chicoric acid results in increased expression of PPARGC1A mRNA CTD PMID:24244361 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP chicoric acid results in increased expression of SOD2 protein CTD PMID:24244361 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      application 19735
        pharmaceutical 19543
          drug 19543
            protective agent 18275
              geroprotector 17408
                chicoric acid 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      tetracarboxylic acid 549
                                        chicoric acid 7
paths to the root