peroxol - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	peroxol	go back to main search page
Accession:	CHEBI:35924	browse the term
Definition:	Monosubstitution products of hydrogen peroxide HOOH, having the skeleton ROOH, in which R is any organyl group.
Synonyms:	related_synonym:	Formula=HO2R; SMILES=OO[*]; a hydroperoxide; hydroperoxides; organic hydroperoxides; peroxols

show annotations for term's descendants Sort by:
Rat (1709) Mouse (1735) Human (1737) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (5) Green Monkey (0) Naked Mole-rat (0) All
Genes (1709)

12(S)-HPETE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione peroxidase 1

increases response to substance

GPX1 protein results in increased susceptibility to 12-HPETE

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

increases chemical synthesis

GPX4 protein results in increased chemical synthesis of 12-HPETE

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

prostaglandin-endoperoxide synthase 2

multiple interactions

12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

13-HPODE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 2

multiple interactions

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

early growth response 1

multiple interactions

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

peroxisome proliferator activated receptor alpha

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

4-hydroperoxycyclophosphamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

increases expression

perfosfamide results in increased expression of ABL1 mRNA

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

actin, beta

decreases expression

perfosfamide results in decreased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

angiotensinogen

decreases response to substance

AGT protein results in decreased susceptibility to perfosfamide

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases response to substance

Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; perfosfamide results in increased expression of and results in increased localization of AIFM1 protein
AIFM1 results in increased susceptibility to perfosfamide

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aldo-keto reductase family 1 member B10

affects response to substance

AKR1B10 protein affects the susceptibility to perfosfamide

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldehyde dehydrogenase 1 family, member A1

decreases response to substance

ALDH1A1 protein results in decreased susceptibility to perfosfamide

PMID:8662658 PMID:16614850

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

decreases response to substance

ALDH1A2 protein results in decreased susceptibility to perfosfamide

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 1 family, member B1

affects response to substance

ALDH1B1 protein affects the susceptibility to perfosfamide

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 2 family member

decreases response to substance

ALDH2 protein results in decreased susceptibility to perfosfamide

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

decreases response to substance

ALDH3A1 protein results in decreased susceptibility to perfosfamide

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

perfosfamide results in decreased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects folding
increases expression

Acetylcysteine inhibits the reaction [perfosfamide affects the folding of BAX protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of BAX]; perfosfamide results in increased expression of and results in increased localization of BAX
perfosfamide results in increased expression of BAX protein

PMID:16488414 PMID:18034189

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

perfosfamide results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

bone morphogenetic protein receptor type 1B

decreases expression

perfosfamide results in decreased expression of BMPR1B mRNA

NCBI chr 2:230,538,252...230,871,077
Ensembl chr 2:230,541,558...230,871,368

G

C1D nuclear receptor corepressor

increases expression

perfosfamide results in increased expression of C1D mRNA

NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852

G

caspase 3

increases activity
multiple interactions

perfosfamide results in increased activity of CASP3
perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein]

PMID:16488414 PMID:17434952

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

perfosfamide results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase inhibitor 1A

increases expression

perfosfamide results in increased expression of CDKN1A
perfosfamide results in increased expression of CDKN1A mRNA; perfosfamide results in increased expression of CDKN1A protein

PMID:17068108 PMID:18034189

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

C-X-C motif chemokine ligand 9

decreases expression

perfosfamide results in decreased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

E2F transcription factor 1

increases expression

perfosfamide results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

decreases expression

perfosfamide results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

endonuclease G

increases response to substance
multiple interactions

ENDOG results in increased susceptibility to perfosfamide
Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of ENDOG protein]; perfosfamide results in increased expression of and results in increased localization of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

endothelial PAS domain protein 1

increases expression

perfosfamide results in increased expression of EPAS1 protein

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor A6

decreases expression

perfosfamide results in decreased expression of EPHA6 mRNA

NCBI chr11:39,757,501...40,708,901
Ensembl chr11:39,757,181...40,698,311

G

EYA transcriptional coactivator and phosphatase 1

decreases expression

perfosfamide results in decreased expression of EYA1 mRNA

NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483

G

Fas ligand

increases expression

perfosfamide results in increased expression of FASLG mRNA; perfosfamide results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

forkhead box F1

affects expression

perfosfamide affects the expression of FOXF1 mRNA

NCBI chr19:49,153,949...49,157,741
Ensembl chr19:49,153,699...49,157,738

G

gap junction protein, gamma 1

increases expression

perfosfamide results in increased expression of GJC1 mRNA

NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867

G

GLI family zinc finger 2

decreases expression

perfosfamide results in decreased expression of GLI2 mRNA

NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574

G

hes family bHLH transcription factor 1

increases expression

perfosfamide results in increased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hypoxia inducible factor 1 subunit alpha

increases expression

perfosfamide results in increased expression of HIF1A mRNA; perfosfamide results in increased expression of HIF1A protein

PMID:19429390 PMID:23251655

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

homeobox A11

decreases expression

perfosfamide results in decreased expression of HOXA11 mRNA

NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232

G

homeo box A13

increases expression

perfosfamide results in increased expression of HOXA13 mRNA

NCBI chr 4:81,358,956...81,361,091
Ensembl chr 4:81,358,956...81,361,091

G

homeo box D10

increases expression

perfosfamide results in increased expression of HOXD10 mRNA

NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725

G

HRas proto-oncogene, GTPase

decreases expression

perfosfamide results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

Klotho

decreases expression

perfosfamide results in decreased expression of KL mRNA

NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080

G

DNA ligase 3

decreases expression

perfosfamide results in decreased expression of LIG3 mRNA

NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414

G

MDM2 proto-oncogene

increases expression

perfosfamide results in increased expression of MDM2

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

O-6-methylguanine-DNA methyltransferase

decreases expression

perfosfamide results in decreased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

mutL homolog 1

decreases expression

perfosfamide results in decreased expression of MLH1 mRNA

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

N-methylpurine-DNA glycosylase

decreases expression

perfosfamide results in decreased expression of MPG mRNA

NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520

G

MRE11 homolog, double strand break repair nuclease

decreases expression

perfosfamide results in decreased expression of MRE11A mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

myosin Ib

increases expression

perfosfamide results in increased expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

myogenin

increases expression

perfosfamide results in increased expression of MYOG mRNA

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

necdin, MAGE family member

increases expression

perfosfamide results in increased expression of NDN mRNA

NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767

G

ornithine decarboxylase 1

decreases expression

perfosfamide results in decreased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

proliferation and apoptosis adaptor protein 15

decreases expression

perfosfamide results in decreased expression of PEA15 mRNA

NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

perfosfamide results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

PMS1 homolog 1, mismatch repair system component

decreases expression

perfosfamide results in decreased expression of PMS1 mRNA

NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237

G

PMS1 homolog 2, mismatch repair system component

decreases expression

perfosfamide results in decreased expression of PMS2 mRNA

NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066

G

DNA polymerase beta

decreases expression

perfosfamide results in decreased expression of POLB mRNA

NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812

G

DNA polymerase delta 1, catalytic subunit

decreases expression

perfosfamide results in decreased expression of POLD1 mRNA

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

RAD21 cohesin complex component

decreases expression

perfosfamide results in decreased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RAD50 double strand break repair protein

decreases expression

perfosfamide results in decreased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

RAD51 recombinase

decreases expression

perfosfamide results in decreased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

stromal cell derived factor 4

decreases expression

perfosfamide results in decreased expression of SDF4 mRNA

NCBI chr 5:166,586,581...166,606,661
Ensembl chr 5:166,586,390...166,604,521

G

secreted frizzled-related protein 2

decreases expression

perfosfamide results in decreased expression of SFRP2 mRNA

NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063

G

solute carrier family 30 member 4

decreases expression

perfosfamide results in decreased expression of SLC30A4 mRNA

NCBI chr 3:109,753,270...109,775,306
Ensembl chr 3:109,753,273...109,775,306

G

SMAD family member 1

decreases expression

perfosfamide results in decreased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

transporter 1, ATP binding cassette subfamily B member

affects response to substance

TAP1 protein affects the susceptibility to perfosfamide

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

transcription factor 12

increases expression

perfosfamide results in increased expression of TCF12 mRNA

NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201

G

telomerase RNA component

decreases expression

perfosfamide results in decreased expression of TERC mRNA

NCBI chr 2:112,815,654...112,816,041

G

telomerase reverse transcriptase

decreases expression

perfosfamide results in decreased expression of TERT mRNA

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tumor necrosis factor

multiple interactions

perfosfamide promotes the reaction [TNF results in increased activity of CASP3 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [perfosfamide results in increased expression of TP53]
perfosfamide results in increased expression of and results in increased phosphorylation of and results in increased activity of TRP53 protein

PMID:17068108 PMID:18034189

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tripartite motif-containing 27

decreases expression

perfosfamide results in decreased expression of TRIM27 mRNA

NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643

G

transcription termination factor 1

decreases expression

perfosfamide results in decreased expression of TTF1 mRNA

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

ubiquitin B

decreases expression

perfosfamide results in decreased expression of UBB mRNA

NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333

G

vascular endothelial growth factor A

increases expression

perfosfamide results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression

perfosfamide results in decreased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 11

increases expression

perfosfamide results in increased expression of WNT11 mRNA

NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294

G

X-ray repair cross complementing 1

decreases expression

perfosfamide results in decreased expression of XRCC1 mRNA

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

X-ray repair cross complementing 5

decreases expression

perfosfamide results in decreased expression of XRCC5 mRNA

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreases expression

perfosfamide results in decreased expression of YWHAZ mRNA

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

9,10,13-TriHOME

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

epoxide hydrolase 3

multiple interactions

[EPHX3 gene mutant form results in decreased hydrolysis of Epoxy Compounds] results in decreased abundance of [9,10,13-trihydroxy-11-octadecenoic acid binds to Ceramides]; [EPHX3 gene mutant form results in decreased hydrolysis of Epoxy Compounds] which results in decreased chemical synthesis of 9,10,13-trihydroxy-11-octadecenoic acid

NCBI chr 7:11,206,812...11,212,122
Ensembl chr 7:11,206,812...11,212,122

cumene hydroperoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity
increases activity
multiple interactions

cumene hydroperoxide results in decreased activity of CAT protein
cumene hydroperoxide results in increased activity of CAT protein
Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]

PMID:12065085 PMID:12423650 PMID:16928893

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects oxidation

CYP2B1 protein affects the oxidation of cumene hydroperoxide

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects oxidation

CYP2B6 protein affects the oxidation of cumene hydroperoxide

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects oxidation

CYP2C19 protein affects the oxidation of cumene hydroperoxide

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 79

affects oxidation

CYP2C8 protein affects the oxidation of cumene hydroperoxide

G

cytochrome P450, family 2, subfamily d, polypeptide 1

affects oxidation

CYP2D1 protein affects the oxidation of cumene hydroperoxide

NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084

G

cytochrome P450, family 2, subfamily s, polypeptide 1

multiple interactions

[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

eukaryotic translation elongation factor 2

multiple interactions
decreases expression

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]
cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein

PMID:16469450 PMID:17510559 PMID:19447174

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

fibroblast growth factor receptor 2

multiple interactions

cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

glucose-6-phosphate dehydrogenase

increases activity

cumene hydroperoxide results in increased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

cumene hydroperoxide results in increased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glutamate-cysteine ligase, catalytic subunit

increases expression

cumene hydroperoxide results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

cumene hydroperoxide results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione peroxidase 1

decreases response to substance
increases metabolic processing
increases reduction

GPX1 protein results in decreased susceptibility to cumene hydroperoxide
GPX1 protein results in increased metabolism of cumene hydroperoxide
GPX1 protein results in increased reduction of cumene hydroperoxide

PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

increases reduction

GPX2 protein results in increased reduction of cumene hydroperoxide

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 4

decreases response to substance

GPX4 results in decreased susceptibility to cumene hydroperoxide

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione-disulfide reductase

decreases activity

cumene hydroperoxide results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

increases metabolic processing

GSTA1 protein results in increased metabolism of cumene hydroperoxide

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

decreases metabolic processing
increases metabolic processing

GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTA2 protein results in increased metabolism of cumene hydroperoxide

PMID:3138230 PMID:15077012 PMID:15128049

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

decreases response to substance
affects metabolic processing

GSTA3 protein results in decreased susceptibility to cumene hydroperoxide
GSTA3 protein affects the metabolism of cumene hydroperoxide

PMID:1740415 PMID:2768223

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase, mu 5

decreases metabolic processing
increases metabolic processing

GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

increases metabolic processing

GSTP1 protein results in increased metabolism of cumene hydroperoxide

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

affects oxidation
affects metabolic processing

GSTT1 protein affects the oxidation of cumene hydroperoxide
GSTT1 protein affects the metabolism of cumene hydroperoxide

PMID:9854036 PMID:19664997

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glutathione S-transferase theta 2

affects metabolic processing

GSTT2 protein affects the metabolism of cumene hydroperoxide

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

glutathione S-transferase zeta 1

affects metabolic processing

GSTZ1 protein affects the metabolism of cumene hydroperoxide

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

glucuronidase, beta

multiple interactions
decreases uptake
increases secretion

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

heme oxygenase 1

increases expression

cumene hydroperoxide results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family B (small) member 1

increases expression

cumene hydroperoxide results in increased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

isocitrate dehydrogenase (NADP(+)) 1

increases activity

cumene hydroperoxide results in increased activity of IDH1 protein

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

interleukin 1 beta

multiple interactions
increases secretion

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

Kelch-like ECH-associated protein 1

multiple interactions

[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

myoglobin

affects metabolic processing

MB protein mutant form affects the metabolism of cumene hydroperoxide

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

microsomal glutathione S-transferase 1

decreases response to substance

MGST1 results in decreased susceptibility to cumene hydroperoxide

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myeloperoxidase

multiple interactions

[9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

increases response to substance
affects response to substance
multiple interactions

NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to cumene hydroperoxide
Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]

PMID:19303893 PMID:19608619 PMID:20932822

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions
increases expression

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression

cumene hydroperoxide results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

ornithine decarboxylase 1

increases activity
multiple interactions

cumene hydroperoxide results in increased activity of ODC1 protein
Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

peptidylprolyl isomerase A

decreases response to substance

PPIA protein results in decreased susceptibility to cumene hydroperoxide

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

peroxiredoxin 1

increases expression

cumene hydroperoxide results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 2

increases expression

cumene hydroperoxide results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 6

increases expression

cumene hydroperoxide results in increased expression of PRDX6 protein

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

cumene hydroperoxide results in increased expression of PTGS2 protein
[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

sorbitol dehydrogenase

increases activity

cumene hydroperoxide results in increased activity of SORD protein

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

transforming growth factor, beta 1

increases expression

cumene hydroperoxide results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions
increases secretion

alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

linoleic acid hydroperoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions
increases lipidation

Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

cytoglobin

increases metabolic processing

CYGB protein results in increased metabolism of linoleic acid hydroperoxide

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

glutathione peroxidase 1

increases reduction

GPX1 protein results in increased reduction of linoleic acid hydroperoxide

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

increases reduction

GPX2 protein results in increased reduction of linoleic acid hydroperoxide

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

tert-butyl hydroperoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

tert-Butylhydroperoxide results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases expression
affects localization

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]; Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein]; Bucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCB11 protein]; tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCB11 protein
tert-Butylhydroperoxide results in decreased expression of ABCB11 mRNA

PMID:16452108 PMID:24306262 PMID:34767876

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression

tert-Butylhydroperoxide results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

decreases expression
affects localization
multiple interactions

tert-Butylhydroperoxide results in decreased expression of ABCC2 mRNA
tert-Butylhydroperoxide affects the localization of ABCC2 protein
Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCC2 protein]; Bilirubin analog inhibits the reaction [tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein]; Go 6976 inhibits the reaction [tert-Butylhydroperoxide affects the localization of ABCC2 protein]; tert-Butylhydroperoxide affects the localization of and results in decreased activity of ABCC2 protein

PMID:22956110 PMID:24306262 PMID:34303734

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily D member 1

increases expression

tert-Butylhydroperoxide results in increased expression of ABCD1 mRNA

NCBI chr X:151,428,334...151,450,115
Ensembl chr X:151,428,578...151,450,115

G

abhydrolase domain containing 17A, depalmitoylase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ABHD17A mRNA

NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762

G

actin-binding LIM protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ABLIM1 mRNA

NCBI chr 1:256,083,747...256,372,075
Ensembl chr 1:256,084,297...256,371,969

G

ABR activator of RhoGEF and GTPase

increases expression

tert-Butylhydroperoxide results in increased expression of ABR mRNA

NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505

G

acyl-CoA dehydrogenase short chain

increases expression
multiple interactions
decreases expression

tert-Butylhydroperoxide results in increased expression of ACADS mRNA
acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein]; tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein

PMID:15003993 PMID:26989860

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acetylcholinesterase

multiple interactions
increases secretion
increases expression

Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of ACHE protein]
tert-Butylhydroperoxide results in increased expression of ACHE mRNA alternative form

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

atypical chemokine receptor 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

aconitase 1

increases expression

tert-Butylhydroperoxide results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

acyl-CoA thioesterase 1

increases expression

tert-Butylhydroperoxide results in increased expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA thioesterase 7

increases expression

tert-Butylhydroperoxide results in increased expression of ACOT7 mRNA

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA synthetase long-chain family member 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

actin, beta

decreases expression

tert-Butylhydroperoxide results in decreased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actin gamma 2, smooth muscle

increases expression

tert-Butylhydroperoxide results in increased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

actinin, alpha 1

increases expression

tert-Butylhydroperoxide results in increased expression of ACTN1 mRNA

NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251

G

actin related protein 3

increases expression

tert-Butylhydroperoxide results in increased expression of ACTR3 mRNA

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

actin related protein 3B

decreases expression

tert-Butylhydroperoxide results in decreased expression of ACTR3B mRNA

NCBI chr 4:9,261,631...9,355,496
Ensembl chr 4:9,262,233...9,355,441

G

aminoacylase 3

increases expression

tert-Butylhydroperoxide results in increased expression of ACY3 mRNA

NCBI chr 1:201,279,751...201,285,803
Ensembl chr 1:201,279,851...201,283,175

G

acylphosphatase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ACYP1 mRNA

NCBI chr 6:104,919,162...104,932,348
Ensembl chr 6:104,919,162...104,932,387

G

ADAM metallopeptidase domain 19

increases expression

tert-Butylhydroperoxide results in increased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 8

increases expression

tert-Butylhydroperoxide results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase domain 9

multiple interactions
affects expression
increases expression

[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADAM9 mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADAM9 mRNA]; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADAM9 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADAM9 mRNA]
tert-Butylhydroperoxide affects the expression of ADAM9 mRNA

PMID:20847119 PMID:23410634

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

adenosine deaminase, RNA-specific

increases expression

tert-Butylhydroperoxide results in increased expression of ADAR mRNA

PMID:14729362 PMID:15003993

NCBI chr 2:175,138,391...175,178,280
Ensembl chr 2:175,138,403...175,178,282

G

adenosine deaminase, tRNA-specific 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADAT1 mRNA

NCBI chr19:39,918,083...39,956,886
Ensembl chr19:39,918,227...39,956,883

G

adenylate cyclase 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADCY3 mRNA

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adenylate cyclase 9

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADCY9 mRNA

NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066

G

adducin 2

increases expression

tert-Butylhydroperoxide results in increased expression of ADD2 mRNA

NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505

G

adducin 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADD3 mRNA

NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124

G

adhesion G protein-coupled receptor G6

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases expression

tert-Butylhydroperoxide results in increased expression of ADH7 mRNA

PMID:14729362 PMID:15336504

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

adiponectin receptor 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

adrenomedullin

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ADM mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ADM mRNA]

PMID:14729362 PMID:15003993 PMID:15336504 PMID:20847119 PMID:29432895

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A1 receptor

decreases expression

tert-Butylhydroperoxide results in decreased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2B receptor

increases expression

tert-Butylhydroperoxide results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

acylglycerol kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of AGK mRNA

NCBI chr 4:69,114,850...69,193,989
Ensembl chr 4:69,114,269...69,193,934

G

argonaute RISC catalytic component 2

increases expression

tert-Butylhydroperoxide results in increased expression of AGO2 mRNA

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

1-acylglycerol-3-phosphate O-acyltransferase 1

increases expression

tert-Butylhydroperoxide results in increased expression of AGPAT1 mRNA

NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278

G

activator of Hsp90 ATPase activity 1

increases expression

tert-Butylhydroperoxide results in increased expression of AHSA1 mRNA

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
increases expression

resveratrol inhibits the reaction [tert-Butylhydroperoxide results in increased expression of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aryl-hydrocarbon receptor-interacting protein

decreases expression

tert-Butylhydroperoxide results in decreased expression of AIP mRNA

NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122

G

ajuba LIM protein

multiple interactions
decreases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA; [Troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of AJUBA mRNA]

NCBI chr15:28,019,775...28,031,537
Ensembl chr15:28,019,778...28,030,021

G

adenylate kinase 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of AK2 mRNA

NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632

G

adenylate kinase 4

increases expression

tert-Butylhydroperoxide results in increased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

A-kinase anchoring protein 12

affects expression

tert-Butylhydroperoxide affects the expression of AKAP12 mRNA

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

A-kinase anchoring protein 9

decreases expression

tert-Butylhydroperoxide results in decreased expression of AKAP9 mRNA

NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606

G

aldo-keto reductase family 1 member B10

increases expression

tert-Butylhydroperoxide results in increased expression of AKR1B10 mRNA

PMID:23410634 PMID:34767876

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

increases expression

tert-Butylhydroperoxide results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

increases expression

tert-Butylhydroperoxide results in increased expression of AKR1C2 mRNA

PMID:12414654 PMID:15336504 PMID:23410634

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

tert-Butylhydroperoxide results in decreased phosphorylation of AKT1 protein
3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased phosphorylation of AKT1 protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of AKT1 mRNA; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of AKT1 mRNA]

PMID:29128606 PMID:35690295

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases expression
increases methylation

tert-Butylhydroperoxide results in decreased expression of AKT2 mRNA
tert-Butylhydroperoxide results in increased methylation of AKT2 gene

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aminolevulinate dehydratase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALAD mRNA

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

5'-aminolevulinate synthase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALAS1 protein

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of ALDH1A1 mRNA
tert-Butylhydroperoxide affects the expression of ALDH1A1 mRNA

PMID:15336504 PMID:23410634

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A3

increases expression

tert-Butylhydroperoxide results in increased expression of ALDH1A3 mRNA

NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436

G

aldehyde dehydrogenase 2 family member

increases expression
decreases response to substance

tert-Butylhydroperoxide results in increased expression of ALDH2 mRNA
ALDH2 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:14729362 PMID:15003993 PMID:15336504

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALDH3A2 mRNA

NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281

G

aldehyde dehydrogenase 4 family, member A1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 7 family, member A1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALDH7A1 mRNA

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

arachidonate 5-lipoxygenase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

adenosylmethionine decarboxylase 1

increases expression

tert-Butylhydroperoxide results in increased expression of AMD1 mRNA

NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476

G

adhesion molecule with Ig like domain 2

increases expression

tert-Butylhydroperoxide results in increased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiomotin like 2

multiple interactions
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA; tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to AMOTL2 promoter]; troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to AMOTL2 promoter]]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of AMOTL2 mRNA]

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

adenosine monophosphate deaminase 3

increases expression

tert-Butylhydroperoxide results in increased expression of AMPD3 mRNA

PMID:15003993 PMID:15336504

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

amphiphysin

decreases expression

tert-Butylhydroperoxide results in decreased expression of AMPH mRNA

PMID:12419474 PMID:15336504

NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315

G

anaphase-promoting complex subunit 5

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANAPC5 mRNA

NCBI chr12:33,748,709...33,781,709
Ensembl chr12:33,748,735...33,781,781

G

angiopoietin-like 2

multiple interactions
increases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA; Pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]

PMID:15003993 PMID:20847119

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin like 7

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANGPTL7 mRNA

NCBI chr 5:158,932,096...158,937,281
Ensembl chr 5:158,932,794...158,937,324

G

ankyrin repeat and MYND domain containing 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANKMY2 mRNA

NCBI chr 6:52,888,959...52,930,343
Ensembl chr 6:52,888,963...52,930,394

G

ankyrin repeat family A member 2

affects expression

tert-Butylhydroperoxide affects the expression of ANKRA2 mRNA

NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730

G

ankyrin repeat domain 10

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANKRD10 mRNA

NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745

G

ankyrin repeat domain 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANKRD2 mRNA

NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566

G

ankyrin repeat domain 37

multiple interactions
increases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANKRD37 mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANKRD37 mRNA; [Troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANKRD37 mRNA; Pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANKRD37 mRNA]; Rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANKRD37 mRNA]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANKRD37 mRNA]

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

ankyrin repeat domain 6

increases expression

tert-Butylhydroperoxide results in increased expression of ANKRD6 mRNA

NCBI chr 5:47,197,981...47,343,183
Ensembl chr 5:47,202,873...47,343,090

G

acidic nuclear phosphoprotein 32 family member A

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANP32A mRNA

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

alanyl aminopeptidase, membrane

increases expression

tert-Butylhydroperoxide results in increased expression of ANPEP mRNA

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

annexin A4

decreases expression

tert-Butylhydroperoxide results in decreased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A8

increases expression

tert-Butylhydroperoxide results in increased expression of ANXA8 mRNA

PMID:14729362 PMID:15003993

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

aldehyde oxidase 1

increases expression

tert-Butylhydroperoxide results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 3 subunit beta 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of AP3B1 mRNA

NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935

G

adaptor related protein complex 3 subunit delta 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of AP3D1 mRNA

NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

tert-Butylhydroperoxide results in increased expression of APAF1 protein
[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of APAF1 mRNA; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of APAF1 mRNA]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of APAF1 mRNA]
Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein]

PMID:15877105 PMID:17419000 PMID:35690295

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor like protein 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of APLP2 mRNA

NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855

G

apolipoprotein A5

affects expression

tert-Butylhydroperoxide affects the expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein E

increases expression
affects localization

tert-Butylhydroperoxide results in increased expression of APOE mRNA
tert-Butylhydroperoxide affects the localization of APOE protein

PMID:15336504 PMID:19720132

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

apolipoprotein L domain containing 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706

G

amyloid beta precursor protein

decreases expression

tert-Butylhydroperoxide results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of APPL1 mRNA

NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692

G

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of APPL2 mRNA

NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754

G

aquaporin 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 4

multiple interactions

tert-Butylhydroperoxide results in increased expression of and affects the localization of AQP4 protein

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquarius intron-binding spliceosomal factor

decreases expression

tert-Butylhydroperoxide results in decreased expression of AQR mRNA

NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044

G

amphiregulin

increases expression

tert-Butylhydroperoxide results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

ADP-ribosylation factor 6

increases expression

tert-Butylhydroperoxide results in increased expression of ARF6 mRNA

NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114

G

arginase 2

affects expression

tert-Butylhydroperoxide affects the expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho GDP dissociation inhibitor alpha

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 10

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

Rho guanine nucleotide exchange factor 7

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARHGEF7 mRNA

NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697

G

AT-rich interaction domain 3A

affects expression

tert-Butylhydroperoxide affects the expression of ARID3A mRNA

NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599

G

ADP-ribosylation factor like GTPase 6 interacting protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

ADP-ribosylation factor like GTPase 6 interacting protein 5

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARL6IP5 mRNA

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of ARNT mRNA; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of ARNT mRNA]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

actin related protein 2/3 complex, subunit 1A

decreases expression

tert-Butylhydroperoxide results in decreased expression of ARPC1A mRNA

NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330

G

anti-silencing function 1A histone chaperone

increases expression

tert-Butylhydroperoxide results in increased expression of ASF1A mRNA

NCBI chr20:32,893,962...32,908,808
Ensembl chr20:32,893,573...32,908,808

G

anti-silencing function 1B histone chaperone

decreases expression

tert-Butylhydroperoxide results in decreased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

aspartate-beta-hydroxylase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ASPH mRNA

NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876

G

ASPSCR1 tether for SLC2A4, UBX domain containing

decreases expression

tert-Butylhydroperoxide results in decreased expression of ASPSCR1 mRNA

NCBI chr10:105,952,215...105,990,059
Ensembl chr10:105,952,227...105,989,904

G

argininosuccinate synthase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ASS1 mRNA; tert-Butylhydroperoxide results in decreased expression of ASS1 protein

PMID:15336504 PMID:24394546

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ASXL transcriptional regulator 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ASXL1 mRNA

NCBI chr 3:141,814,012...141,881,526
Ensembl chr 3:141,813,433...141,881,538

G

ATPase family, AAA domain containing 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 3

multiple interactions
decreases expression
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ATF3 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ATF3 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ATF3 mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ATF3 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ATF3 mRNA]
tert-Butylhydroperoxide results in decreased expression of ATF3 mRNA

PMID:12414654 PMID:20196124 PMID:20847119

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

autophagy related 4B, cysteine peptidase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATG4B mRNA

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 5

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATPase 13A3

increases expression

tert-Butylhydroperoxide results in increased expression of ATP13A3 mRNA

NCBI chr11:70,364,998...70,442,005
Ensembl chr11:70,365,322...70,441,235

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

ATPase plasma membrane Ca2+ transporting 1

increases expression

tert-Butylhydroperoxide results in increased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATPase H+ transporting V1 subunit A

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit C1

increases expression

tert-Butylhydroperoxide results in increased expression of ATP6V1C1 mRNA

NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278

G

ATR serine/threonine kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

ataxin 1

affects localization
decreases expression
multiple interactions

tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form
tert-Butylhydroperoxide results in decreased expression of ATXN1 mRNA
Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]; Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]

PMID:12893416 PMID:15336504

NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360

G

ataxin 3

increases expression

tert-Butylhydroperoxide results in increased expression of ATXN3 mRNA

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

aurora kinase A

increases expression

tert-Butylhydroperoxide results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of AURKB mRNA
tert-Butylhydroperoxide results in increased expression of AURKB mRNA

PMID:12414654 PMID:29432895

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

activator of transcription and developmental regulator AUTS2

decreases expression

tert-Butylhydroperoxide results in decreased expression of AUTS2 mRNA

NCBI chr12:24,104,187...25,194,123
Ensembl chr12:24,104,192...25,194,416

G

antizyme inhibitor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of AZIN1 mRNA

NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578

G

BRISC and BRCA1 A complex member 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BABAM1 mRNA

NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923

G

BRISC and BRCA1 A complex member 2

increases expression

tert-Butylhydroperoxide results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

beta-secretase 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of BACE2 mRNA

NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546

G

BCL2-associated agonist of cell death

decreases expression
increases expression
multiple interactions

tert-Butylhydroperoxide results in decreased expression of BAD mRNA
tert-Butylhydroperoxide results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]

PMID:12419474 PMID:15569404 PMID:17419000

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BMP and activin membrane-bound inhibitor

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of BAMBI mRNA
tert-Butylhydroperoxide affects the expression of BAMBI mRNA

PMID:15336504 PMID:23410634

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects localization
increases expression
decreases expression

1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of BAX mRNA; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of BAX mRNA]; hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of BAX protein]; LY96 protein affects the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]; LY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of BAX mRNA]; Peptides inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
tert-Butylhydroperoxide results in decreased expression of BAX mRNA

PMID:12419474 PMID:15569404 PMID:17419000 PMID:18552516 PMID:20510348 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

decreases expression

tert-Butylhydroperoxide results in decreased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

bublin coiled coil protein

decreases expression

tert-Butylhydroperoxide results in decreased expression of BBLN mRNA

NCBI chr 3:15,674,577...15,677,322
Ensembl chr 3:15,674,580...15,677,374

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
affects localization

acadesine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide affects the localization of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide affects the localization of BCL2 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]
1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; 3,4-dihydroxyphenyllactic acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in decreased expression of BCL2 mRNA; Genistein inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; LY96 protein affects the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in decreased expression of BCL2 mRNA]; Peptides inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]
tert-Butylhydroperoxide results in decreased expression of BCL2 mRNA; tert-Butylhydroperoxide results in decreased expression of BCL2 protein

PMID:12782109 PMID:15288519 PMID:15569404 PMID:17419000 PMID:19772912 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
tert-Butylhydroperoxide results in decreased expression of BCL2L1 mRNA; tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein
Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]; puag-haad inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]

PMID:12419474 PMID:15569404 PMID:26102008 PMID:27050144

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 13

decreases expression

tert-Butylhydroperoxide results in decreased expression of BCL2L13 mRNA

NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

brain-derived neurotrophic factor

increases expression

tert-Butylhydroperoxide results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

brain expressed X-linked 2

increases expression

tert-Butylhydroperoxide results in increased expression of BEX1 mRNA

NCBI chr X:99,019,847...99,021,375
Ensembl chr X:99,019,000...99,021,503

G

brain expressed, X-linked 4

increases expression

tert-Butylhydroperoxide results in increased expression of BEX4 mRNA

NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531

G

betaine-homocysteine S-methyltransferase

increases methylation
decreases expression

tert-Butylhydroperoxide results in increased methylation of BHMT gene
tert-Butylhydroperoxide results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

BICD cargo adaptor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BICD1 mRNA

NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434

G

BCL2-interacting killer

increases expression

tert-Butylhydroperoxide results in increased expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 5

increases expression

tert-Butylhydroperoxide results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basophilic leukemia expressed protein BLES03

increases expression

tert-Butylhydroperoxide results in increased expression of C11ORF68 mRNA

NCBI chr 1:202,734,555...202,736,809
Ensembl chr 1:202,734,555...202,736,804

G

B-cell linker

increases expression

tert-Butylhydroperoxide results in increased expression of BLNK mRNA

NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113

G

basic helix-loop-helix ARNT like 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of BMAL2 mRNA

NCBI chr 4:179,699,432...179,747,710
Ensembl chr 4:179,699,502...179,746,949

G

bMERB domain containing 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BMERB1 mRNA

NCBI chr10:1,779,834...1,946,586
Ensembl chr10:1,779,835...1,946,575

G

bone morphogenetic protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

bone morphogenetic protein 4

decreases expression

tert-Butylhydroperoxide results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 3

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of BNIP3 mRNA
tert-Butylhydroperoxide results in increased expression of BNIP3 mRNA

PMID:12419474 PMID:15003993

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

bora, aurora kinase A activator

decreases expression

tert-Butylhydroperoxide results in decreased expression of BORA mRNA

NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of BRAF mRNA

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

bromodomain containing 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of BRD3 mRNA

NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577

G

BRD3 opposite strand

decreases expression

tert-Butylhydroperoxide results in decreased expression of BRD3OS mRNA

NCBI chr 3:10,770,229...10,771,860

G

BSCL2 lipid droplet biogenesis associated, seipin

increases expression

tert-Butylhydroperoxide results in increased expression of BSCL2 mRNA

NCBI chr 1:205,731,828...205,743,430
Ensembl chr 1:205,733,872...205,743,421

G

bone marrow stromal cell antigen 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BST1 mRNA

NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180

G

bone marrow stromal cell antigen 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

BTB domain containing 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of BTBD2 mRNA

NCBI chr 7:9,058,609...9,075,341
Ensembl chr 7:9,060,788...9,075,344

G

biotinidase

decreases expression

tert-Butylhydroperoxide results in decreased expression of BTD mRNA

NCBI chr16:6,863,068...6,894,345
Ensembl chr16:6,862,407...6,940,945

G

basic transcription factor 3

increases expression

tert-Butylhydroperoxide results in increased expression of BTF3 mRNA

NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879

G

BTG anti-proliferation factor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 2

increases expression

tert-Butylhydroperoxide results in increased expression of BTG2 mRNA

PMID:12414654 PMID:21382384

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase

affects expression

tert-Butylhydroperoxide affects the expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUD23, rRNA methyltransferase and ribosome maturation factor

decreases expression

tert-Butylhydroperoxide results in decreased expression of BUD23 mRNA

NCBI chr12:21,629,551...21,640,758
Ensembl chr12:21,629,536...21,640,751

G

basic leucine zipper and W2 domains 1

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of BZW1 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of BZW1 mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BZW1 mRNA]; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BZW1 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BZW1 mRNA]

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

similar to human chromosome 17 open reading frame 100

affects expression

tert-Butylhydroperoxide affects the expression of C17ORF100 mRNA

NCBI chr10:56,840,451...56,843,674
Ensembl chr10:56,832,412...56,843,871

G

similar to human chromosome 1 open reading frame 115

decreases expression

tert-Butylhydroperoxide results in decreased expression of C1ORF115 mRNA

NCBI chr13:96,422,308...96,432,044
Ensembl chr13:96,422,302...96,432,068

G

similar to human chromosome 6 open reading frame 62

affects expression

tert-Butylhydroperoxide affects the expression of C6ORF62 mRNA

NCBI chr17:40,256,211...40,267,851
Ensembl chr17:40,256,211...40,276,020

G

complement C1r

decreases expression

tert-Butylhydroperoxide results in decreased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

G

C2 calcium-dependent domain containing 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of C2CD2 mRNA

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739

G

complement C5

decreases expression

tert-Butylhydroperoxide results in decreased expression of C5 mRNA

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

similar to human chromosome 8 open reading frame 76

affects expression

tert-Butylhydroperoxide affects the expression of C8ORF76 mRNA

NCBI chr 7:89,558,890...89,569,810
Ensembl chr 7:89,558,909...89,569,810

G

cell adhesion molecule 1

increases expression

tert-Butylhydroperoxide results in increased expression of CADM1 mRNA

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

cell adhesion molecule 4

decreases expression

tert-Butylhydroperoxide results in decreased expression of CADM4 mRNA

NCBI chr 1:80,075,163...80,097,423
Ensembl chr 1:80,075,202...80,097,423

G

calcium homeostasis modulator family member 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CALHM2 mRNA

NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218

G

calmodulin 1

increases expression

tert-Butylhydroperoxide results in increased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin 3

increases expression

tert-Butylhydroperoxide results in increased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

calmodulin-like 4

increases expression

tert-Butylhydroperoxide results in increased expression of CALML4 mRNA

NCBI chr 8:63,323,426...63,335,234
Ensembl chr 8:63,323,351...63,335,234

G

calreticulin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calumenin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CALU mRNA

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

increases expression

tert-Butylhydroperoxide results in increased expression of CAMK2N1 mRNA

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

calcium modulating ligand

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAML mRNA

NCBI chr17:8,992,697...9,003,576
Ensembl chr17:8,992,696...9,003,552

G

cathelicidin antimicrobial peptide

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAMP mRNA

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

cullin-associated and neddylation-dissociated 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAND1 mRNA

NCBI chr 7:54,681,114...54,719,002
Ensembl chr 7:54,680,900...54,718,993

G

calpain 1

increases response to substance
increases expression

CAPN1 protein results in increased susceptibility to tert-Butylhydroperoxide
tert-Butylhydroperoxide results in increased expression of CAPN1 mRNA

PMID:12842444 PMID:15003993

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of CAPN2 mRNA
tert-Butylhydroperoxide affects the expression of CAPN2 mRNA

PMID:12419474 PMID:23410634

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

calpain 5

increases expression

tert-Butylhydroperoxide results in increased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

G

calpain 7

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAPN7 mRNA

NCBI chr16:6,545,630...6,581,908
Ensembl chr16:6,545,731...6,581,905

G

calpain, small subunit 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAPNS1 mRNA

NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795

G

caprin family member 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAPRIN2 mRNA

NCBI chr 4:181,806,105...181,860,754
Ensembl chr 4:181,806,575...181,860,830

G

carbonic anhydrase 8

decreases expression

tert-Butylhydroperoxide results in decreased expression of CA8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

cysteinyl-tRNA synthetase 2, mitochondrial

decreases expression

tert-Butylhydroperoxide results in decreased expression of CARS2 mRNA

NCBI chr16:77,945,468...77,987,163
Ensembl chr16:77,950,008...77,987,772

G

calcium/calmodulin dependent serine protein kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 3

multiple interactions
decreases activity
increases cleavage
decreases expression
increases activity
increases expression

1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA]; Drugs, Chinese Herbal inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CASP3 protein]; GPX4 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; LY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form]; MCL1 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP3 mRNA]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; nectandrin-B inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; PAFAH2 protein inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; puag-haad inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CASP3 protein]; rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]
tert-butylhydroperoxide decreases activity of Casp3 protein in hepatocyte cytosol
acadesine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]
6,7-dihydroxyflavone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; caffeoylquinic acid analog inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Drugs, Chinese Herbal inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; tert-Butylhydroperoxide results in increased expression of and results in increased cleavage of CASP3 protein
tert-Butylhydroperoxide results in increased expression of CASP3 protein; tert-Butylhydroperoxide results in increased expression of CASP3 protein modified form

CTD
RGD

PMID:12406338 PMID:15496407 PMID:15569404 PMID:15611089 PMID:15877105 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

increases expression

tert-Butylhydroperoxide results in increased expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

multiple interactions
decreases activity
increases cleavage

Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP7 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP7 protein]
tert-butylhydroperoxide decreases activity of Casp7 protein in hepatocyte cytosol

CTD
RGD

PMID:27050144 PMID:18316105

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP8 mRNA; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP8 mRNA]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CASP8 mRNA]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage
decreases activity
multiple interactions
increases expression

tert-Butylhydroperoxide results in increased cleavage of CASP9 protein
Tert-butylhydroperoxide decreases activity of Casp9 protein in hepatocyte cytosol
Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP9 protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP9 protein]
tert-Butylhydroperoxide results in increased expression of CASP9 protein
Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP9 protein]; Silymarin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP9 protein]

CTD
RGD

PMID:15877105 PMID:17003459 PMID:19772912 PMID:20510348 PMID:27050144 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAST mRNA

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

affects response to substance
increases activity
decreases activity
multiple interactions
increases expression
decreases expression
decreases response to substance

CAT protein affects the susceptibility to tert-Butylhydroperoxide
tert-Butylhydroperoxide results in increased activity of CAT protein
tert-Butylhydroperoxide results in decreased activity of CAT protein
CAT protein results in increased susceptibility to [tert-Butylhydroperoxide co-treated with Desoxycorticosterone co-treated with tempol]
tert-Butylhydroperoxide results in increased expression of CAT mRNA
CAT protein inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]; CAT protein inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]; Catechin inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of CAT protein]
tert-Butylhydroperoxide results in decreased expression of CAT mRNA; tert-Butylhydroperoxide results in decreased expression of CAT protein
[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CAT mRNA; Oleanolic Acid inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CAT protein]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CAT protein]
CAT protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:10754530 PMID:11178967 PMID:12423650 PMID:12628296 PMID:12646410 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

increases expression

tert-Butylhydroperoxide results in increased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolin 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CAV2 mRNA

NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244

G

caveolae associated protein 2

affects expression

tert-Butylhydroperoxide affects the expression of CAVIN2 mRNA

NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147

G

core-binding factor subunit beta

decreases expression

tert-Butylhydroperoxide results in decreased expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

G

carbonyl reductase 3

increases expression

tert-Butylhydroperoxide results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

cystathionine beta synthase

decreases expression
increases methylation

tert-Butylhydroperoxide results in decreased expression of CBS mRNA
tert-Butylhydroperoxide results in increased methylation of CBS gene

PMID:15336504 PMID:27509014

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

coiled-coil domain containing 25

decreases expression

tert-Butylhydroperoxide results in decreased expression of CCDC25 mRNA

NCBI chr15:40,055,368...40,087,758
Ensembl chr15:40,055,368...40,087,758

G

coiled-coil domain containing 86

increases expression

tert-Butylhydroperoxide results in increased expression of CCDC86 mRNA

NCBI chr 1:207,590,167...207,596,547
Ensembl chr 1:207,590,168...207,596,544

G

coiled-coil domain containing 93

increases expression

tert-Butylhydroperoxide results in increased expression of CCDC93 mRNA

NCBI chr13:32,607,618...32,675,993
Ensembl chr13:32,607,587...32,676,023

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCL2 mRNA; tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CCL2 promoter]; troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CCL2 promoter]]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

increases expression

tert-Butylhydroperoxide results in increased expression of CCL5 mRNA

PMID:14729362 PMID:15003993

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

increases expression

tert-Butylhydroperoxide results in increased expression of CCN1 mRNA

PMID:12414654 PMID:15336504

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

multiple interactions
affects expression
decreases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCN2 mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCN2 mRNA; [Troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCN2 mRNA; Pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CCN2 mRNA]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CCN2 mRNA]
tert-Butylhydroperoxide affects the expression of CCN2 mRNA

PMID:20847119 PMID:23410634

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin A2

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of CCNA2 mRNA
tert-Butylhydroperoxide affects the expression of CCNA2 mRNA

PMID:12414654 PMID:12419474 PMID:15336504 PMID:23410634

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B2

increases expression

tert-Butylhydroperoxide results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin E1

multiple interactions

ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CCNE1 protein]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin F

increases expression

tert-Butylhydroperoxide results in increased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

cyclin G2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cyclin J

increases expression

tert-Butylhydroperoxide results in increased expression of CCNJ mRNA

NCBI chr 1:239,659,588...239,677,367

G

cyclin K

decreases expression

tert-Butylhydroperoxide results in decreased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

copper chaperone for superoxide dismutase

increases expression

tert-Butylhydroperoxide results in increased expression of CCS mRNA

PMID:14729362 PMID:15336504

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

CD24 molecule

increases expression

tert-Butylhydroperoxide results in increased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

CD320 molecule

decreases expression

tert-Butylhydroperoxide results in decreased expression of CD320 mRNA

NCBI chr 7:14,626,171...14,631,976
Ensembl chr 7:14,609,146...14,631,976

G

CD46 molecule

decreases expression

tert-Butylhydroperoxide results in decreased expression of CD46 mRNA

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

Cd47 molecule

decreases expression

tert-Butylhydroperoxide results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CD55 molecule (Cromer blood group)

increases expression

tert-Butylhydroperoxide results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd68 molecule

increases expression
decreases response to substance

tert-Butylhydroperoxide results in increased expression of CD68 mRNA
CD68 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:14729362 PMID:15003993 PMID:15336504

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd82 molecule

increases expression

tert-Butylhydroperoxide results in increased expression of CD82 mRNA

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

G

CD9 molecule

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of CD9 mRNA
tert-Butylhydroperoxide affects the expression of CD9 mRNA

PMID:15336504 PMID:23410634

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

CD99 molecule (Xg blood group)

decreases expression

tert-Butylhydroperoxide results in decreased expression of CD99 mRNA

NCBI chr20:54,418,239...54,422,882

G

cell division cycle 16

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 25B

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of CDC25C mRNA
tert-Butylhydroperoxide results in increased expression of CDC25C mRNA

PMID:12419474 PMID:14729362 PMID:15003993

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 27

increases expression

tert-Butylhydroperoxide results in increased expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 37-like 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDC37L1 mRNA

NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175

G

cell division cycle 42

increases expression

tert-Butylhydroperoxide results in increased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

CDC42 effector protein 2

increases expression

tert-Butylhydroperoxide results in increased expression of CDC42EP2 mRNA

NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897

G

CDC42 effector protein 3

increases expression

tert-Butylhydroperoxide results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

CDC42 effector protein 4

affects expression

tert-Butylhydroperoxide affects the expression of CDC42EP4 mRNA

NCBI chr10:98,772,613...98,797,924
Ensembl chr10:98,772,495...98,797,695

G

CDC42 small effector 1

increases expression

tert-Butylhydroperoxide results in increased expression of CDC42SE1 mRNA

NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028

G

cell division cycle 5-like

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cell division cycle associated 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

CUB domain containing protein 1

increases expression

tert-Butylhydroperoxide results in increased expression of CDCP1 mRNA

NCBI chr 8:122,828,685...122,865,345
Ensembl chr 8:122,828,685...122,865,388

G

cadherin 11

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cadherin 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cadherin 5

increases expression

tert-Butylhydroperoxide results in increased expression of CDH5 mRNA

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

cyclin-dependent kinase 1

increases expression

tert-Butylhydroperoxide results in increased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin dependent kinase 2

decreases activity
decreases expression
multiple interactions

tert-Butylhydroperoxide results in decreased activity of CDK2 protein
tert-Butylhydroperoxide results in decreased expression of CDK2 mRNA
ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDK2 protein]

PMID:12766906 PMID:15336504 PMID:15606011

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

tert-Butylhydroperoxide results in increased expression of CDKN1A mRNA; tert-Butylhydroperoxide results in increased expression of CDKN1A protein
[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1A mRNA; ginsenoside Rg1 affects the reaction [tert-Butylhydroperoxide affects the expression of CDKN1A protein]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1A mRNA]; Niacinamide inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1A protein]; Plant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1A protein]

PMID:12414654 PMID:12766906 PMID:12782109 PMID:15336504 PMID:15606011 More...

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

multiple interactions
increases expression
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]; tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CDKN1C promoter]; troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CDKN1C promoter]]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]
tert-Butylhydroperoxide results in decreased expression of CDKN1C mRNA

PMID:12419474 PMID:20847119

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2B

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDKN2B mRNA

PMID:12419474 PMID:14729362

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cyclin-dependent kinase inhibitor 2C

decreases expression

tert-Butylhydroperoxide results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

increases expression

tert-Butylhydroperoxide results in increased expression of CDKN3 mRNA

PMID:15003993 PMID:27509014

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein alpha

affects expression

tert-Butylhydroperoxide affects the expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression

tert-Butylhydroperoxide results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CUGBP, Elav-like family member 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CELF2 mRNA

NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333

G

cadherin, EGF LAG seven-pass G-type receptor 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of CELSR2 mRNA

NCBI chr 2:196,029,206...196,053,848
Ensembl chr 2:196,029,434...196,053,845

G

centromere protein A

decreases expression

tert-Butylhydroperoxide results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein M

decreases expression

tert-Butylhydroperoxide results in decreased expression of CENPM mRNA

NCBI chr 7:113,748,026...113,759,296
Ensembl chr 7:113,747,516...113,764,258

G

centrosomal protein 170

increases expression

tert-Butylhydroperoxide results in increased expression of CEP170 mRNA

NCBI chr13:88,669,672...88,754,011
Ensembl chr13:88,670,358...88,732,226

G

centrosomal protein 170B

increases expression

tert-Butylhydroperoxide results in increased expression of CEP170B mRNA

NCBI chr 6:131,780,935...131,806,658
Ensembl chr 6:131,778,957...131,806,658

G

centrosomal protein 192

decreases expression

tert-Butylhydroperoxide results in decreased expression of CEP192 mRNA

NCBI chr18:61,373,937...61,458,405
Ensembl chr18:61,332,158...61,458,379

G

centrosomal protein 43

increases expression

tert-Butylhydroperoxide results in increased expression of CEP43 mRNA

NCBI chr 1:52,533,418...52,564,025
Ensembl chr 1:52,533,428...52,563,923

G

centrosomal protein 57

decreases expression

tert-Butylhydroperoxide results in decreased expression of CEP57 mRNA

NCBI chr 8:10,669,588...10,689,257
Ensembl chr 8:10,669,590...10,689,249

G

centrosomal protein 89

increases expression

tert-Butylhydroperoxide results in increased expression of CEP89 mRNA

NCBI chr 1:88,058,211...88,100,114
Ensembl chr 1:88,058,227...88,100,112

G

complement factor B

decreases expression

tert-Butylhydroperoxide results in decreased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

complement factor I

decreases expression

tert-Butylhydroperoxide results in decreased expression of CFI mRNA

NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561

G

chromatin assembly factor 1 subunit A

decreases expression

tert-Butylhydroperoxide results in decreased expression of CHAF1A mRNA

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

choline dehydrogenase

decreases expression

tert-Butylhydroperoxide results in decreased expression of CHDH mRNA

NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537

G

checkpoint kinase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

choline kinase alpha

affects expression

tert-Butylhydroperoxide affects the expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

charged multivesicular body protein 2A

decreases expression

tert-Butylhydroperoxide results in decreased expression of CHMP2A mRNA

NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452

G

cysteine and histidine rich domain containing 1

increases expression

tert-Butylhydroperoxide results in increased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

chordin-like 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CHRDL1 mRNA

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

G

carbohydrate sulfotransferase 15

affects expression

tert-Butylhydroperoxide affects the expression of CHST15 mRNA

NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707

G

carbohydrate sulfotransferase 2

increases expression

tert-Butylhydroperoxide results in increased expression of CHST2 mRNA

NCBI chr 8:95,960,067...95,966,312
Ensembl chr 8:95,959,826...95,966,955

G

cytoplasmic linker associated protein 1

decreases methylation
decreases expression

tert-Butylhydroperoxide results in decreased methylation of CLASP1 intron
tert-Butylhydroperoxide results in decreased expression of CLASP1 mRNA

NCBI chr13:29,493,554...29,715,151
Ensembl chr13:29,493,596...29,715,146

G

chloride voltage-gated channel 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CLCN3 mRNA

NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119

G

chloride intracellular channel 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CLIC3 mRNA

NCBI chr 3:8,271,416...8,274,023
Ensembl chr 3:8,272,097...8,274,018

G

CLN3 lysosomal/endosomal transmembrane protein, battenin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CLN3 mRNA

NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434

G

CLN6, transmembrane ER protein

increases expression

tert-Butylhydroperoxide results in increased expression of CLN6 mRNA

NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360

G

calsyntenin 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CLSTN1 mRNA

NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583

G

clusterin

increases expression

tert-Butylhydroperoxide results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

CKLF-like MARVEL transmembrane domain containing 1

decreases methylation

tert-Butylhydroperoxide results in decreased methylation of CMTM1 gene

NCBI chr19:651,641...661,184
Ensembl chr19:651,644...661,184

G

carnosine dipeptidase 2

increases expression

tert-Butylhydroperoxide results in increased expression of CNDP2 mRNA

NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922

G

cyclin and CBS domain divalent metal cation transport mediator 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of CNNM3 mRNA

NCBI chr 9:38,755,374...38,770,740
Ensembl chr 9:38,755,390...38,770,740

G

CCR4-NOT transcription complex, subunit 8

decreases expression

tert-Butylhydroperoxide results in decreased expression of CNOT8 mRNA

NCBI chr10:42,281,614...42,294,740
Ensembl chr10:42,281,722...42,294,730

G

component of oligomeric golgi complex 5

decreases expression

tert-Butylhydroperoxide results in decreased expression of COG5 mRNA

NCBI chr 6:48,242,470...48,545,185
Ensembl chr 6:48,242,482...48,529,009

G

component of oligomeric golgi complex 8

multiple interactions
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of COG8 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of COG8 mRNA; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of COG8 mRNA]

NCBI chr19:34,951,625...34,962,377
Ensembl chr19:34,951,627...34,962,397

G

collagen type XIII alpha 1 chain

increases expression

tert-Butylhydroperoxide results in increased expression of COL13A1 mRNA

NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032

G

collagen type I alpha 2 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type IV alpha 2 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL4A2 mRNA

NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839

G

collagen type V alpha 1 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VI alpha 1 chain

increases expression

tert-Butylhydroperoxide results in increased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VI alpha 2 chain

increases expression

tert-Butylhydroperoxide results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collagen type VII alpha 1 chain

increases expression

tert-Butylhydroperoxide results in increased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

collagen type VIII alpha 2 chain

decreases expression

tert-Butylhydroperoxide results in decreased expression of COL8A2 mRNA

NCBI chr 5:138,586,201...138,613,627
Ensembl chr 5:138,585,999...138,612,850

G

catechol-O-methyltransferase

decreases expression

tert-Butylhydroperoxide results in decreased expression of COMT mRNA
tert-Butylhydroperoxide results in decreased expression of COMT protein

PMID:12419474 PMID:24394546

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

COPI coat complex subunit alpha

decreases expression

tert-Butylhydroperoxide results in decreased expression of COPA mRNA

NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874

G

COPI coat complex subunit beta 1

increases expression

tert-Butylhydroperoxide results in increased expression of COPB1 mRNA

NCBI chr 1:168,404,334...168,438,589
Ensembl chr 1:168,404,335...168,438,416

G

COPI coat complex subunit epsilon

decreases expression

tert-Butylhydroperoxide results in decreased expression of COPE mRNA

NCBI chr16:19,114,871...19,125,076
Ensembl chr16:19,114,871...19,128,907

G

COP9 signalosome subunit 6

decreases expression

tert-Butylhydroperoxide results in decreased expression of COPS6 mRNA

NCBI chr12:17,038,979...17,041,818
Ensembl chr12:17,038,979...17,046,371

G

COP9 signalosome subunit 8

decreases expression

tert-Butylhydroperoxide results in decreased expression of COPS8 mRNA

NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258

G

cytochrome c oxidase subunit 7A1

increases expression

tert-Butylhydroperoxide results in increased expression of COX7A1 mRNA

NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151

G

ceruloplasmin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carboxypeptidase E

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of CPE mRNA
tert-Butylhydroperoxide results in increased expression of CPE mRNA

PMID:12419474 PMID:15336504

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

carboxypeptidase M

increases expression

tert-Butylhydroperoxide results in increased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

copine 1

increases expression

tert-Butylhydroperoxide results in increased expression of CPNE1 mRNA

NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636

G

carboxypeptidase Q

decreases expression

tert-Butylhydroperoxide results in decreased expression of CPQ mRNA

NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546

G

carnitine O-acetyltransferase

decreases expression

tert-Butylhydroperoxide results in decreased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

cAMP responsive element binding protein 1

decreases expression
increases phosphorylation
multiple interactions

tert-Butylhydroperoxide results in decreased expression of CREB1 mRNA
tert-Butylhydroperoxide results in increased phosphorylation of CREB1 protein
U 0126 inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of CREB1 protein]

PMID:12419474 PMID:17003459

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cysteine rich protein 1

increases expression

tert-Butylhydroperoxide results in increased expression of CRIP1 mRNA

NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620

G

cysteine-rich secretory protein LCCL domain containing 2

increases expression

tert-Butylhydroperoxide results in increased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

crystallin, alpha B

multiple interactions
decreases expression
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CRYAB mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CRYAB mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CRYAB mRNA]
tert-Butylhydroperoxide results in decreased expression of CRYAB mRNA

PMID:15336504 PMID:20847119

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin zeta

decreases response to substance
increases expression

CRYZ protein results in decreased susceptibility to tert-Butylhydroperoxide
tert-Butylhydroperoxide results in increased expression of CRYZ mRNA

PMID:14729362 PMID:15003993 PMID:15336504

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

colony stimulating factor 1

decreases response to substance

CSF1 protein results in decreased susceptibility to tert-Butylhydroperoxide

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

casein kinase 1, delta

decreases expression

tert-Butylhydroperoxide results in decreased expression of CSNK1D mRNA

NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614

G

chondroitin sulfate proteoglycan 4

increases expression

tert-Butylhydroperoxide results in increased expression of CSPG4 mRNA

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

CTD small phosphatase like

decreases expression

tert-Butylhydroperoxide results in decreased expression of CTDSPL mRNA

NCBI chr 8:118,642,729...118,767,238
Ensembl chr 8:118,642,672...118,767,117

G

cystathionine gamma-lyase

increases activity

tert-Butylhydroperoxide results in increased activity of CTH protein

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

catenin alpha 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CTNNB1 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CTNNB1 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CTNNB1 mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CTNNB1 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

increases expression

tert-Butylhydroperoxide results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

increases expression
decreases expression

tert-Butylhydroperoxide results in increased expression of CTSL mRNA
tert-Butylhydroperoxide results in decreased expression of CTSL mRNA

PMID:12419474 PMID:15336504

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cortactin

decreases expression

tert-Butylhydroperoxide results in decreased expression of CTTN mRNA

NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164

G

cullin 3

multiple interactions
increases expression

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 protein]
tert-Butylhydroperoxide results in increased expression of CUL3 mRNA; tert-Butylhydroperoxide results in increased expression of CUL3 protein

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

cullin 4A

decreases expression

tert-Butylhydroperoxide results in decreased expression of CUL4A mRNA

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

cut-like homeobox 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CUX1 mRNA

NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866

G

CXADR, Ig-like cell adhesion molecule

decreases expression

tert-Butylhydroperoxide results in decreased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine ligand 1

increases expression

tert-Butylhydroperoxide results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

increases expression

tert-Butylhydroperoxide results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

increases expression

tert-Butylhydroperoxide results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

tert-Butylhydroperoxide results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CXCR4 mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]; tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]; troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CXCR4 promoter]]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CXCR4 mRNA]

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

CXXC finger protein 5

decreases expression

tert-Butylhydroperoxide results in decreased expression of CXXC5 mRNA

NCBI chr18:27,427,591...27,458,579
Ensembl chr18:27,427,230...27,458,673

G

cytochrome b-561

decreases expression

tert-Butylhydroperoxide results in decreased expression of CYB561 mRNA

NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787

G

cytochrome b5 domain containing 2

affects expression

tert-Butylhydroperoxide affects the expression of CYB5D2 mRNA

NCBI chr10:57,394,268...57,413,336
Ensembl chr10:57,396,765...57,413,715

G

cytochrome b5 reductase 2

increases expression

tert-Butylhydroperoxide results in increased expression of CYB5R2 mRNA

NCBI chr 1:161,655,862...161,664,359
Ensembl chr 1:161,655,864...161,664,097

G

cytochrome b-245 chaperone 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of CYBC1 mRNA

NCBI chr10:106,498,730...106,505,549
Ensembl chr10:106,498,725...106,505,596

G

cytochrome c, somatic

affects localization
multiple interactions

tert-Butylhydroperoxide affects the localization of CYCS protein
hyperoside inhibits the reaction [tert-Butylhydroperoxide affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytoglobin

increases expression

tert-Butylhydroperoxide results in increased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

tert-Butylhydroperoxide results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

affects expression

tert-Butylhydroperoxide affects the expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

CYFIP related Rac1 interactor A

increases expression

tert-Butylhydroperoxide results in increased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

death associated protein 3

increases expression

tert-Butylhydroperoxide results in increased expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

death associated protein kinase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DAPK1 mRNA

PMID:12419474 PMID:15336504

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

aspartyl-tRNA synthetase 1

increases expression

tert-Butylhydroperoxide results in increased expression of DARS1 mRNA

NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116

G

DAZ associated protein 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of DAZAP2 mRNA

NCBI chr 7:131,714,749...131,720,266
Ensembl chr 7:131,714,745...131,720,265

G

diazepam binding inhibitor

decreases expression

tert-Butylhydroperoxide results in decreased expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

DDB1 and CUL4 associated factor 7

decreases expression

tert-Butylhydroperoxide results in decreased expression of DCAF7 mRNA

NCBI chr10:90,974,095...90,996,275
Ensembl chr10:90,974,095...90,996,275

G

dynactin subunit 5

decreases methylation

tert-Butylhydroperoxide results in decreased methylation of DCTN5 gene

NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906

G

damage specific DNA binding protein 2

increases expression

tert-Butylhydroperoxide results in increased expression of DDB2 mRNA

NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

tert-Butylhydroperoxide results in increased expression of DDIT3 mRNA; tert-Butylhydroperoxide results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DDIT3 protein]; ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DDIT3 protein]

PMID:12414654 PMID:22659508 PMID:24394546

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

affects expression

tert-Butylhydroperoxide affects the expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

DEAD/H-box helicase 11

decreases expression

tert-Butylhydroperoxide results in decreased expression of DDX11 mRNA

NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550

G

DExD-box helicase 21

increases expression

tert-Butylhydroperoxide results in increased expression of DDX21 mRNA

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

DEAD-box helicase 42

increases expression

tert-Butylhydroperoxide results in increased expression of DDX42 mRNA

NCBI chr10:91,148,926...91,180,940
Ensembl chr10:91,148,254...91,180,939

G

DEAD-box helicase 43

increases expression

tert-Butylhydroperoxide results in increased expression of DDX43 mRNA

NCBI chr 8:79,255,001...79,284,468
Ensembl chr 8:79,255,655...79,284,453

G

DExD-box helicase 50

decreases expression

tert-Butylhydroperoxide results in decreased expression of DDX50 mRNA

NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152

G

DExD-box helicase 52

increases expression

tert-Butylhydroperoxide results in increased expression of DDX52 mRNA

NCBI chr10:68,824,594...68,847,400
Ensembl chr10:68,824,645...68,848,266

G

DEAD-box helicase 56

increases expression

tert-Butylhydroperoxide results in increased expression of DDX56 mRNA

NCBI chr14:81,112,008...81,122,331
Ensembl chr14:81,112,012...81,122,333

G

DEAD-box helicase 6

increases expression

tert-Butylhydroperoxide results in increased expression of DDX6 mRNA

NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405

G

DENN domain containing 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of DENND3 mRNA

NCBI chr 7:105,415,870...105,473,583
Ensembl chr 7:105,415,677...105,473,592

G

DEPP autophagy regulator 1

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DEPP1 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DEPP1 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DEPP1 mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DEPP1 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DEPP1 mRNA]

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

derlin 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DERL1 mRNA

NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145

G

DNA fragmentation factor subunit beta

decreases expression

tert-Butylhydroperoxide results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

diacylglycerol O-acyltransferase 2

affects expression

tert-Butylhydroperoxide affects the expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

deoxyhypusine synthase

decreases expression

tert-Butylhydroperoxide results in decreased expression of DHPS mRNA

NCBI chr19:23,082,454...23,086,544
Ensembl chr19:23,082,448...23,086,881

G

DExH-box helicase 9

decreases expression

tert-Butylhydroperoxide results in decreased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

DIM1 rRNA methyltransferase and ribosome maturation factor

decreases expression

tert-Butylhydroperoxide results in decreased expression of DIMT1 mRNA

NCBI chr 2:38,343,086...38,368,242
Ensembl chr 2:38,354,854...38,368,227

G

disco-interacting protein 2 homolog C

decreases expression

tert-Butylhydroperoxide results in decreased expression of DIP2C mRNA

NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

tert-Butylhydroperoxide results in increased expression of DKK1 mRNA

PMID:12414654 PMID:15336504

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

discs large MAGUK scaffold protein 1

multiple interactions
increases expression

[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DLG1 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of DLG1 mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DLG1 mRNA]; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DLG1 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DLG1 mRNA]

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

discs large MAGUK scaffold protein 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of DLG3 mRNA

NCBI chr X:65,859,653...65,911,887
Ensembl chr X:65,860,172...65,910,322

G

DLG associated protein 4

increases expression

tert-Butylhydroperoxide results in increased expression of DLGAP4 mRNA

NCBI chr 3:145,124,189...145,271,791
Ensembl chr 3:145,175,479...145,270,490

G

DLG associated protein 5

increases expression
affects expression

tert-Butylhydroperoxide results in increased expression of DLGAP5 mRNA
tert-Butylhydroperoxide affects the expression of DLGAP5 mRNA

PMID:15003993 PMID:23410634

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

distal-less homeobox 2

increases expression

tert-Butylhydroperoxide results in increased expression of DLX2 mRNA

PMID:14729362 PMID:29432895

NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597

G

DM1 protein kinase

increases expression

tert-Butylhydroperoxide results in increased expression of DMPK mRNA

NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593

G

dynein, axonemal, assembly factor 2

multiple interactions
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of DNAAF2 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of DNAAF2 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of DNAAF2 mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of DNAAF2 mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of DNAAF2 mRNA]

NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199

G

DnaJ heat shock protein family (Hsp40) member B1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B11

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNAJB11 mRNA

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

DnaJ heat shock protein family (Hsp40) member B4

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B7

decreases methylation

tert-Butylhydroperoxide results in decreased methylation of DNAJB7 intron

NCBI chr 7:112,932,736...112,934,050
Ensembl chr 7:112,932,616...112,945,537

G

deoxyribonuclease 2, lysosomal

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNASE2 mRNA

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

dynamin 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNM2 mRNA

NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157

G

dynamin binding protein

increases expression

tert-Butylhydroperoxide results in increased expression of DNMBP mRNA

NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

dedicator of cytokinesis 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of DOCK2 mRNA

NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808

G

dedicator of cytokinesis 4

increases expression

tert-Butylhydroperoxide results in increased expression of DOCK4 mRNA

NCBI chr 6:57,512,929...57,902,597
Ensembl chr 6:57,512,908...57,901,855

G

dipeptidylpeptidase 4

increases expression

tert-Butylhydroperoxide results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dpy-19 like C-mannosyltransferase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DPY19L1 mRNA

NCBI chr 8:22,933,163...23,021,461
Ensembl chr 8:22,933,163...23,021,751

G

dihydropyrimidinase-like 3

increases expression

tert-Butylhydroperoxide results in increased expression of DPYSL3 mRNA

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

Dr1 associated protein 1

increases expression

tert-Butylhydroperoxide results in increased expression of DRAP1 mRNA

NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425

G

desmocollin 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of DSC3 mRNA

NCBI chr18:11,379,759...11,413,797
Ensembl chr18:11,377,347...11,413,797

G

dystonin

decreases expression

tert-Butylhydroperoxide results in decreased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

dual specificity phosphatase 1

affects expression

tert-Butylhydroperoxide affects the expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 10

multiple interactions
increases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DUSP10 mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DUSP10 mRNA; [Troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of DUSP10 mRNA; Rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DUSP10 mRNA]; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DUSP10 mRNA]

PMID:15336504 PMID:20847119

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 5

increases expression

tert-Butylhydroperoxide results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of DUSP6 mRNA
tert-Butylhydroperoxide results in increased expression of DUSP6 mRNA

PMID:15336504 PMID:17003459

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dual specificity phosphatase 9

affects expression

tert-Butylhydroperoxide affects the expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

deoxyuridine triphosphatase

decreases expression

tert-Butylhydroperoxide results in decreased expression of DUT mRNA

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

dishevelled segment polarity protein 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of DVL3 mRNA

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

dynein light chain LC8-type 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

dynein light chain roadblock-type 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of DYNLRB1 mRNA

NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227

G

E2F transcription factor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

enoyl-CoA hydratase 1

increases expression

tert-Butylhydroperoxide results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

enoyl CoA hydratase domain containing 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ECHDC2 mRNA

NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859

G

enoyl-CoA hydratase, short chain 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

enoyl-CoA delta isomerase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

ECSIT signaling integrator

decreases expression

tert-Butylhydroperoxide results in decreased expression of ECSIT mRNA

NCBI chr 8:20,605,583...20,618,453
Ensembl chr 8:20,605,583...20,618,390

G

EGF like repeats and discoidin domains 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

endothelin 1

increases expression
affects expression

tert-Butylhydroperoxide results in increased expression of EDN1 mRNA
tert-Butylhydroperoxide affects the expression of EDN1 mRNA

PMID:12414654 PMID:23410634

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of EEF2 protein

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

EGF containing fibulin extracellular matrix protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

EF-hand domain family, member D1

decreases expression

tert-Butylhydroperoxide results in decreased expression of EFHD1 mRNA

NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917

G

ephrin A4

decreases expression

tert-Butylhydroperoxide results in decreased expression of EFNA4 mRNA

NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979

G

embryonal Fyn-associated substrate

increases expression

tert-Butylhydroperoxide results in increased expression of EFS mRNA

NCBI chr15:28,392,417...28,403,016
Ensembl chr15:28,392,187...28,401,902

G

epidermal growth factor receptor

multiple interactions

[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of EGFR mRNA; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of EGFR mRNA]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
affects expression

tert-Butylhydroperoxide results in increased expression of EGR1 mRNA
tert-Butylhydroperoxide affects the expression of EGR1 mRNA

PMID:12414654 PMID:23410634

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2-alpha kinase 2

increases expression

tert-Butylhydroperoxide results in increased expression of EIF2AK2 mRNA

PMID:14729362 PMID:15003993

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2B subunit delta

increases expression

tert-Butylhydroperoxide results in increased expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 3, subunit M

increases expression

tert-Butylhydroperoxide results in increased expression of EIF3M mRNA

NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392

G

eukaryotic translation initiation factor 5

increases expression

tert-Butylhydroperoxide results in increased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5B

increases expression

tert-Butylhydroperoxide results in increased expression of EIF5B mRNA

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

ELAV like RNA binding protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ELAVL1 mRNA

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

E74 like ETS transcription factor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

E74 like ETS transcription factor 5

increases expression

tert-Butylhydroperoxide results in increased expression of ELF5 mRNA

NCBI chr 3:89,808,837...89,836,977
Ensembl chr 3:89,797,880...89,836,973

G

elongin B

decreases expression

tert-Butylhydroperoxide results in decreased expression of ELOB mRNA

NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635

G

essential meiotic structure-specific endonuclease 1

increases expression

tert-Butylhydroperoxide results in increased expression of EME1 mRNA

NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435

G

elastin microfibril interfacer 1

affects expression

tert-Butylhydroperoxide affects the expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

EMAP like 1

increases expression

tert-Butylhydroperoxide results in increased expression of EML1 mRNA

NCBI chr 6:127,283,968...127,457,246
Ensembl chr 6:127,284,029...127,457,246

G

EMAP like 4

decreases expression

tert-Butylhydroperoxide results in decreased expression of EML4 mRNA

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

epithelial membrane protein 3

increases expression

tert-Butylhydroperoxide results in increased expression of EMP3 mRNA

NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988

G

endoglin

increases expression

tert-Butylhydroperoxide results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

erythrocyte membrane protein band 4.1-like 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of EPB41L2 mRNA

NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721

G

erythrocyte membrane protein band 4.2

increases degradation

tert-Butylhydroperoxide results in increased degradation of EPB42 protein

NCBI chr 3:107,979,709...107,997,932
Ensembl chr 3:107,979,713...107,997,932

G

Eph receptor B2

increases expression

tert-Butylhydroperoxide results in increased expression of EPHB2 mRNA

NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059

G

EPH receptor B4

decreases expression

tert-Butylhydroperoxide results in decreased expression of EPHB4 mRNA

NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314

G

epoxide hydrolase 1

increases expression

tert-Butylhydroperoxide results in increased expression of EPHX1 mRNA

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

increases expression

tert-Butylhydroperoxide results in increased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

erb-b2 receptor tyrosine kinase 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 4

decreases expression

tert-Butylhydroperoxide results in decreased expression of ERBB4 mRNA

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

erbb2 interacting protein

multiple interactions
increases expression

[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of ERBIN mRNA; pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ERBIN mRNA]; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ERBIN mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ERBIN mRNA]

NCBI chr 2:34,926,962...35,028,440
Ensembl chr 2:34,928,863...35,027,852

G

ERCC excision repair 5, endonuclease

decreases expression

tert-Butylhydroperoxide results in decreased expression of ERCC5 mRNA

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]; ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]; tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum protein 29

decreases expression

tert-Butylhydroperoxide results in decreased expression of ERP29 mRNA

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

endothelial cell-specific molecule 1

increases expression

tert-Butylhydroperoxide results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

ess-2 splicing factor homolog

increases expression

tert-Butylhydroperoxide results in increased expression of ESS2 mRNA

NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846

G

eukaryotic translation termination factor 1

increases expression

tert-Butylhydroperoxide results in increased expression of ETF1 mRNA

NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810

G

electron transfer flavoprotein subunit alpha

multiple interactions
decreases expression
increases expression

ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [ERN1 protein binds to TRAF2 protein]]; ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide results in increased expression of DDIT3 protein]; ETFA mutant form inhibits the reaction [tert-Butylhydroperoxide results in increased expression of NFKB1 protein]; pyrazolanthrone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ETFA protein]
tert-Butylhydroperoxide results in decreased expression of ETFA protein

NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969

G

electron transfer flavoprotein subunit beta

decreases expression
increases methylation

tert-Butylhydroperoxide results in decreased expression of ETFB mRNA
tert-Butylhydroperoxide results in increased methylation of ETFB gene

PMID:15336504 PMID:29432895

NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068

G

ETS proto-oncogene 1, transcription factor

decreases expression

tert-Butylhydroperoxide results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

ETS proto-oncogene 2, transcription factor

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of ETS2 mRNA
tert-Butylhydroperoxide results in increased expression of ETS2 mRNA

PMID:12419474 PMID:15336504

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 3

decreases expression

tert-Butylhydroperoxide results in decreased expression of ETV3 mRNA

NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314

G

ETS variant transcription factor 4

increases expression

tert-Butylhydroperoxide results in increased expression of ETV4 mRNA

NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974

G

ETS variant transcription factor 5

increases expression

tert-Butylhydroperoxide results in increased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

exonuclease 1

multiple interactions

[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of EXO1 mRNA; Antineoplastic Agents, Immunological inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of EXO1 mRNA]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of EXO1 mRNA]

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

exocyst complex component 7

decreases expression

tert-Butylhydroperoxide results in decreased expression of EXOC7 mRNA

NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

decreases expression

tert-Butylhydroperoxide results in decreased expression of EZH2 mRNA

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

ezrin

decreases expression

tert-Butylhydroperoxide results in decreased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

F2R like trypsin receptor 1

affects expression

tert-Butylhydroperoxide affects the expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

fumarylacetoacetate hydrolase

decreases expression

tert-Butylhydroperoxide results in decreased expression of FAH protein

NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505

G

family with sequence similarity 110, member B

increases expression

tert-Butylhydroperoxide results in increased expression of FAM110B mRNA

NCBI chr 5:18,789,362...18,929,647
Ensembl chr 5:18,789,389...18,929,828

G

FAM111 trypsin like peptidase A

decreases expression

tert-Butylhydroperoxide results in decreased expression of FAM111A mRNA

NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547

G

family with sequence similarity 13, member B

decreases expression

tert-Butylhydroperoxide results in decreased expression of FAM13B mRNA

NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587

G

family with sequence similarity 171, member A1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FAM171A1 mRNA

NCBI chr17:75,024,582...75,148,348
Ensembl chr17:75,024,575...75,150,255

G

family with sequence similarity 210, member A

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of FAM210A mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of FAM210A mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of FAM210A mRNA; rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FAM210A mRNA]; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FAM210A mRNA]

NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171

G

FA complementation group I

decreases expression

tert-Butylhydroperoxide results in decreased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

FERM, ARH/RhoGEF and pleckstrin domain protein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FARP1 mRNA

NCBI chr15:98,124,304...98,363,299
Ensembl chr15:98,182,329...98,363,299

G

Fas cell surface death receptor

increases expression

tert-Butylhydroperoxide results in increased expression of FAS mRNA

PMID:12414654 PMID:27509014

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas-activated serine/threonine kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of FASTK mRNA

PMID:12419474 PMID:15336504

NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430

G

fibulin 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

F-box protein 30

increases expression

tert-Butylhydroperoxide results in increased expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

farnesyl diphosphate synthase

decreases expression

tert-Butylhydroperoxide results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin 1

increases expression

tert-Butylhydroperoxide results in increased expression of FDX1 mRNA

PMID:14729362 PMID:15336504

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

ferredoxin reductase

increases expression

tert-Butylhydroperoxide results in increased expression of FDXR mRNA

PMID:12414654 PMID:27509014

NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658

G

flap structure-specific endonuclease 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FEN1 mRNA

PMID:12414654 PMID:15336504

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FERM domain containing kindlin 2

increases expression

tert-Butylhydroperoxide results in increased expression of FERMT2 mRNA

NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811

G

fibrinogen gamma chain

increases expression

tert-Butylhydroperoxide results in increased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

fumarate hydratase

decreases expression

tert-Butylhydroperoxide results in decreased expression of FH mRNA

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

four and a half LIM domains 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

four and a half LIM domains 2

increases expression

tert-Butylhydroperoxide results in increased expression of FHL2 mRNA

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

formin homology 2 domain containing 3

increases expression

tert-Butylhydroperoxide results in increased expression of FHOD3 mRNA

NCBI chr18:15,993,079...16,425,796
Ensembl chr18:15,993,324...16,425,796

G

FGF1 intracellular binding protein

decreases expression

tert-Butylhydroperoxide results in decreased expression of FIBP mRNA

NCBI chr 1:202,768,065...202,772,405
Ensembl chr 1:202,768,078...202,772,399

G

fission, mitochondrial 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FIS1 mRNA

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

four-jointed box kinase 1

multiple interactions
decreases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of FJX1 mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of FJX1 mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of FJX1 mRNA; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of FJX1 mRNA]

NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321

G

FKBP prolyl isomerase 1A

increases expression

tert-Butylhydroperoxide results in increased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

FKBP prolyl isomerase 8

decreases expression

tert-Butylhydroperoxide results in decreased expression of FKBP8 mRNA

NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612

G

filamin B

increases expression

tert-Butylhydroperoxide results in increased expression of FLNB mRNA

NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

fibronectin 1

increases expression

tert-Butylhydroperoxide results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

folate receptor alpha

increases expression
decreases expression

tert-Butylhydroperoxide results in increased expression of FOLR1 mRNA
tert-Butylhydroperoxide results in decreased expression of FOLR1 mRNA

PMID:14729362 PMID:15003993 PMID:22956110

NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases methylation
increases expression
multiple interactions

tert-Butylhydroperoxide results in decreased expression of FOS mRNA
tert-Butylhydroperoxide results in increased methylation of FOS gene
tert-Butylhydroperoxide results in increased expression of FOS mRNA
CAT protein inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]; Thiourea inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA]

PMID:12419474 PMID:15105052 PMID:27509014

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

tert-Butylhydroperoxide results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box D1

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of FOXD1 mRNA
tert-Butylhydroperoxide results in increased expression of FOXD1 mRNA

PMID:15003993 PMID:15336504

NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978

G

forkhead box M1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FOXM1 mRNA

PMID:12414654 PMID:15336504

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

ferritin light chain 1

increases expression

tert-Butylhydroperoxide results in increased expression of FTL mRNA

PMID:12414654 PMID:15963989

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

far upstream element binding protein 1

increases expression

tert-Butylhydroperoxide results in increased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

FXYD domain-containing ion transport regulator 5

increases expression

tert-Butylhydroperoxide results in increased expression of FXYD5 mRNA

PMID:14729362 PMID:15003993 PMID:15336504

NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519

G

FYVE and coiled-coil domain autophagy adaptor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FYCO1 mRNA

NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021

G

frizzled class receptor 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FZD1 mRNA

NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643

G

fizzy and cell division cycle 20 related 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of FZR1 mRNA

NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952

G

G0/G1switch 2

increases expression

tert-Butylhydroperoxide results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphate dehydrogenase

decreases activity
increases activity

tert-Butylhydroperoxide results in decreased activity of G6PD protein
tert-Butylhydroperoxide results in increased activity of G6PD protein

PMID:12628296 PMID:15336504 PMID:16928893

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, beta

decreases expression
affects expression

tert-Butylhydroperoxide results in decreased expression of GADD45B mRNA
tert-Butylhydroperoxide affects the expression of GADD45B mRNA

PMID:15336504 PMID:23410634

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

cyclin G associated kinase

decreases expression

tert-Butylhydroperoxide results in decreased expression of GAK mRNA

NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398

G

galactose mutarotase

increases expression

tert-Butylhydroperoxide results in increased expression of GALM mRNA

NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310

G

galactosamine (N-acetyl)-6-sulfatase

decreases expression

tert-Butylhydroperoxide results in decreased expression of GALNS mRNA

NCBI chr19:50,628,639...50,662,477
Ensembl chr19:50,628,552...50,662,246

G

polypeptide N-acetylgalactosaminyltransferase 1

increases expression

tert-Butylhydroperoxide results in increased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

polypeptide N-acetylgalactosaminyltransferase 3

increases methylation
decreases methylation

tert-Butylhydroperoxide results in increased methylation of GALNT3 intron
tert-Butylhydroperoxide results in decreased methylation of GALNT3 intron

NCBI chr 3:50,742,500...50,779,266
Ensembl chr 3:50,742,512...50,766,268

G

polypeptide N-acetylgalactosaminyltransferase 6

increases expression

tert-Butylhydroperoxide results in increased expression of GALNT6 mRNA

NCBI chr 7:131,789,836...131,828,077
Ensembl chr 7:131,789,839...131,819,661

G

glucosidase II alpha subunit

decreases expression

tert-Butylhydroperoxide results in decreased expression of GANAB mRNA

NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

tert-Butylhydroperoxide results in increased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glycyl-tRNA synthetase 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of GARS1 mRNA

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

growth arrest-specific 2

increases expression

tert-Butylhydroperoxide results in increased expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619

G

growth arrest-specific 2 like 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of GAS2L1 mRNA

NCBI chr14:79,955,350...79,961,830
Ensembl chr14:79,950,555...79,961,438

G

GATA binding protein 6

increases expression

tert-Butylhydroperoxide results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

glutamine amidotransferase class 1 domain containing 3A

decreases expression

tert-Butylhydroperoxide results in decreased expression of GATD3 mRNA

NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885

G

guanylate binding protein 2

increases expression

tert-Butylhydroperoxide results in increased expression of GBP2 mRNA

PMID:14729362 PMID:15003993

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

G

guanylate binding protein 4

increases expression

tert-Butylhydroperoxide results in increased expression of GBP3 mRNA

PMID:14729362 PMID:15003993

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

guanylate binding protein family member 6

increases expression

tert-Butylhydroperoxide results in increased expression of GBP6 mRNA

PMID:14729362 PMID:15003993

NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
Ensembl chr14:4,730,453...4,839,062

G

GTP cyclohydrolase I feedback regulator

decreases expression

tert-Butylhydroperoxide results in decreased expression of GCHFR mRNA

NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression
increases expression
decreases response to substance

[Linoleic Acids, Conjugated results in increased activity of GCLC protein] which results in decreased susceptibility to tert-Butylhydroperoxide
tert-Butylhydroperoxide results in decreased expression of GCLC mRNA
tert-Butylhydroperoxide results in increased expression of GCLC mRNA
[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [Luteolin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
GCLC protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:12425961 PMID:17092368 PMID:22864849 PMID:23410634 PMID:27509014 More...

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
tert-Butylhydroperoxide results in increased expression of GCLM mRNA

PMID:12414654 PMID:22864849 PMID:23410634 PMID:27509014 PMID:30547568

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 1

increases expression

tert-Butylhydroperoxide results in increased expression of GCNT1 mRNA

NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

tert-Butylhydroperoxide results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 15

increases expression

tert-Butylhydroperoxide results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 5

affects expression

tert-Butylhydroperoxide affects the expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

GTP binding protein overexpressed in skeletal muscle

multiple interactions
increases expression

[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA; [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA; [troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of GEM mRNA; troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of GEM mRNA]

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

gem (nuclear organelle) associated protein 4

multiple interactions
decreases expression

[Pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA; [Rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of GEMIN4 mRNA; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of GEMIN4 mRNA]

NCBI chr10:61,062,420...61,073,529
Ensembl chr10:61,066,425...61,073,431
Ensembl chr10:61,066,425...61,073,431

G

glial fibrillary acidic protein

decreases expression
increases expression

tert-Butylhydroperoxide results in decreased expression of GFAP protein
tert-Butylhydroperoxide results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth factor, augmenter of liver regeneration

increases expression

tert-Butylhydroperoxide results in increased expression of GFER mRNA

NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869

G

glutamine-fructose-6-phosphate transaminase 2

increases expression

tert-Butylhydroperoxide results in increased expression of GFPT2 mRNA

NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329

G

GDNF family receptor alpha 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of GFRA1 mRNA

NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473

G

GINS complex subunit 2

decreases expression

tert-Butylhydroperoxide results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

gap junction protein, alpha 1

decreases expression
decreases response to substance

tert-Butylhydroperoxide results in decreased expression of GJA1 mRNA; tert-Butylhydroperoxide results in decreased expression of GJA1 protein
GJA1 protein results in decreased susceptibility to tert-Butylhydroperoxide

PMID:15336504 PMID:18235030

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 2

decreases response to substance

GJB2 protein results in decreased susceptibility to tert-Butylhydroperoxide

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

galactosidase, alpha

increases expression

tert-Butylhydroperoxide results in increased expression of GLA mRNA

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

golgi glycoprotein 1

decreases expression

tert-Butylhydroperoxide results in decreased expression of GLG1 mRNA

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178