CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phosphine
Accession: CHEBI:35883
browse the term
Definition: Phosphane (PH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RPH2, R2PH, R3P (R =/= H) are called primary, secondary and tertiary phosphines, respectively. A specific phosphine is preferably named as a substituted phosphane.
Synonyms: related_synonym: fosfinas; phosphines
xref: PMID:14629181; PMID:21241104; PMID:21399776; PMID:21699183; PMID:21714575; PMID:21854058; PMID:21957974
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Abcb10
ATP binding cassette subfamily B member 10
increases expression
EXP
phosphine results in increased expression of ABCB10 mRNA
CTD
PMID:34427094
NCBI chr19:51,952,655...51,982,910
Ensembl chr19:51,952,681...51,982,753
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Agtr1a
angiotensin II receptor, type 1a
increases expression
EXP
phosphine results in increased expression of AGTR1 mRNA
CTD
PMID:34427094
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Aplnr
apelin receptor
decreases expression
EXP
phosphine results in decreased expression of APLNR mRNA
CTD
PMID:34427094
NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
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Bmp6
bone morphogenetic protein 6
affects expression
EXP
phosphine affects the expression of BMP6 mRNA
CTD
PMID:34427094
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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Bmpr1a
bone morphogenetic protein receptor type 1A
increases expression
EXP
phosphine results in increased expression of BMPR1A mRNA
CTD
PMID:34427094
NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616
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Cbl
Cbl proto-oncogene
affects expression
EXP
phosphine affects the expression of CBL mRNA
CTD
PMID:34427094
NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
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Ccn2
cellular communication network factor 2
increases expression
EXP
phosphine results in increased expression of CTGF mRNA
CTD
PMID:34427094
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Ciao2b
cytosolic iron-sulfur assembly component 2B
increases expression
EXP
phosphine results in increased expression of CIAO2B mRNA
CTD
PMID:34427094
NCBI chr19:344,194...346,068
Ensembl chr19:344,203...346,068
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Cp
ceruloplasmin
increases expression
EXP
phosphine results in increased expression of CP mRNA
CTD
PMID:34427094
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Epas1
endothelial PAS domain protein 1
increases expression
EXP
phosphine results in increased expression of EPAS1 mRNA
CTD
PMID:34427094
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Epor
erythropoietin receptor
affects expression
EXP
phosphine affects the expression of EPOR mRNA
CTD
PMID:34427094
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
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Grb2
growth factor receptor bound protein 2
decreases expression
EXP
phosphine results in decreased expression of GRB2 mRNA
CTD
PMID:34427094
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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Hmox1
heme oxygenase 1
increases expression
EXP
phosphine results in increased expression of HMOX1 mRNA
CTD
PMID:34427094
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hscb
HscB mitochondrial iron-sulfur cluster co-chaperone
increases expression
EXP
phosphine results in increased expression of HSCB mRNA
CTD
PMID:34427094
NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909
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Ireb2
iron responsive element binding protein 2
affects expression
EXP
phosphine affects the expression of IREB2 mRNA
CTD
PMID:34427094
NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
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Jak2
Janus kinase 2
decreases expression
EXP
phosphine results in decreased expression of JAK2 mRNA
CTD
PMID:34427094
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
phosphine results in increased expression of JUN mRNA
CTD
PMID:34427094
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Lyrm4
LYR motif containing 4
increases expression
EXP
phosphine results in increased expression of LYRM4 mRNA
CTD
PMID:34427094
NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750
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Nos3
nitric oxide synthase 3
increases expression
EXP
phosphine results in increased expression of NOS3 mRNA
CTD
PMID:34427094
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Pcbp1
poly(rC) binding protein 1
affects expression
EXP
phosphine affects the expression of PCBP1 mRNA
CTD
PMID:34427094
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
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Pdk1
pyruvate dehydrogenase kinase 1
affects expression
EXP
phosphine affects the expression of PDK1 mRNA
CTD
PMID:34427094
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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Serpine1
serpin family E member 1
increases expression
EXP
phosphine results in increased expression of SERPINE1 mRNA
CTD
PMID:34427094
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc25a37
solute carrier family 25 member 37
increases expression
EXP
phosphine results in increased expression of SLC25A37 mRNA
CTD
PMID:34427094
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
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Smad4
SMAD family member 4
increases expression
EXP
phosphine results in increased expression of SMAD4 mRNA
CTD
PMID:34427094
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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Socs1
suppressor of cytokine signaling 1
increases expression
EXP
phosphine results in increased expression of SOCS1 mRNA
CTD
PMID:34427094
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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Socs3
suppressor of cytokine signaling 3
increases expression
EXP
phosphine results in increased expression of SOCS3 mRNA
CTD
PMID:34427094
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
increases expression
EXP
phosphine results in increased expression of SRC mRNA
CTD
PMID:34427094
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Stat5a
signal transducer and activator of transcription 5A
decreases expression
EXP
phosphine results in decreased expression of STAT5 mRNA
CTD
PMID:34427094
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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Tfrc
transferrin receptor
increases expression
EXP
phosphine results in increased expression of TFRC mRNA
CTD
PMID:34427094
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Twsg1
twisted gastrulation BMP signaling modulator 1
decreases expression
EXP
phosphine results in decreased expression of TWSG1 mRNA
CTD
PMID:34427094
NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479
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As3mt
arsenite methyltransferase
multiple interactions affects folding increases reduction
EXP ISO
tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic] tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite] tris(2-carboxyethyl)phosphine affects the folding of AS3MT protein tris(2-carboxyethyl)phosphine results in increased reduction of AS3MT protein
CTD
PMID:15025511 PMID:22955273 PMID:25349987
NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
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Crygd
crystallin, gamma D
decreases oxidation
ISO
[tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein] which results in decreased oxidation of CRYGD mRNA mutant form; tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein
CTD
PMID:30242128
NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:66,442,054...66,444,067
G
Mtf1
metal-regulatory transcription factor 1
multiple interactions
ISO
tris(2-carboxyethyl)phosphine inhibits the reaction [Cadmium promotes the reaction [MTF1 protein binds to MTF1 protein]]; tris(2-carboxyethyl)phosphine inhibits the reaction [Copper promotes the reaction [MTF1 protein binds to MTF1 protein]]
CTD
PMID:22057392
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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Neil1
nei-like DNA glycosylase 1
multiple interactions
ISO
[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [Hydrogen Peroxide results in decreased activity of NEIL1 protein]
CTD
PMID:20622253
NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
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Slc34a1
solute carrier family 34 member 1
decreases activity
EXP
tris(2-carboxyethyl)phosphine results in decreased activity of SLC34A1 protein
CTD
PMID:10926679
NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852
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Txn1
thioredoxin 1
multiple interactions
ISO
tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [sodium chromate(VI) results in increased oxidation of TXN protein]
CTD
PMID:19135121 PMID:19703554
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Txn2
thioredoxin 2
multiple interactions
ISO
tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN2 protein]
CTD
PMID:19703554
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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