lipoxygenase inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lipoxygenase inhibitor	go back to main search page
Accession:	CHEBI:35856	browse the term
Definition:	A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.
Synonyms:	related_synonym:	lipooxygenase inhibitor; lipoxygenase inhibitors

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Genes (1601)

2,5-dihydroxybenzoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA]

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

angiotensin converting enzyme 2

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA]

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

angiotensin II receptor, type 1a

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA]

NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660

G

amyloid beta precursor protein

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

catalase

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; 2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]

PMID:15454305 PMID:37120126

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

crystallin zeta

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein]

NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:246,211,156...246,239,470

G

cytochrome b-245 beta chain

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of CYBB mRNA]

NCBI chr X:16,030,596...16,065,065
Ensembl chr X:16,030,596...16,065,065

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

ISO

2,5-dihydroxybenzoic acid results in decreased activity of G6PD protein mutant form
2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein]

PMID:5432368 PMID:15454305

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutathione-disulfide reductase

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

interleukin 10

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

microRNA 200a

multiple interactions

ISO

2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A]

NCBI chr 5:171,930,717...171,930,805

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

2,5-dihydroxybenzoic acid promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

ornithine decarboxylase 1

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

superoxide dismutase 1

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

sulfotransferase family 1A member 1

increases activity
increases expression

ISO
EXP

2,5-dihydroxybenzoic acid results in increased activity of SULT1A1 protein
2,5-dihydroxybenzoic acid results in increased expression of SULT1A1 mRNA

PMID:16308312 PMID:16443358

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 2A member 1

increases expression

EXP

2,5-dihydroxybenzoic acid results in increased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

transforming growth factor, beta 1

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions

ISO

2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; 2,5-dihydroxybenzoic acid inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily D member 2

increases expression

ISO

MK-886 results in increased expression of ABCD2 mRNA

NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:124,142,595...124,191,202

G

aminocarboxymuconate semialdehyde decarboxylase

multiple interactions

EXP

MK-886 inhibits the reaction [pirinixic acid results in decreased expression of ACMSD mRNA]

NCBI chr13:41,752,894...41,798,427
Ensembl chr13:41,752,875...41,798,427

G

acyl-CoA oxidase 1

multiple interactions
increases expression

EXP
ISO

MK-886 inhibits the reaction [pirinixic acid results in increased expression of ACOX1 mRNA]
MK-886 results in increased expression of ACOX1 mRNA

PMID:18292206 PMID:18320257

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

actin alpha 2, smooth muscle

multiple interactions

ISO

MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

arachidonate 5-lipoxygenase

multiple interactions
decreases activity

ISO
EXP

MK-886 inhibits the reaction [ALOX5 protein results in increased metabolism of Hydroxyeicosatetraenoic Acids metabolite]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]
MK-886 results in decreased activity of ALOX5 protein
EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]

PMID:9445378 PMID:11861792 PMID:14726295 PMID:19896470 PMID:20061081

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

arachidonate 5-lipoxygenase activating protein

multiple interactions
decreases activity

ISO
EXP

[MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4; MK-886 binds to and results in decreased activity of ALOX5AP protein; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]

PMID:7990266 PMID:8058773 PMID:8666909 PMID:9113110 PMID:9609743 More...

NCBI chr12:10,785,254...10,809,295
Ensembl chr12:10,785,257...10,817,038

G

apolipoprotein A1

multiple interactions
decreases expression

ISO

MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]
MK-886 results in decreased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

ISO

MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]
MK-886 results in increased activity of CASP3 protein

PMID:20061081 PMID:22308955

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

C-C motif chemokine ligand 2

multiple interactions

EXP

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein]

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cadherin 1

multiple interactions

ISO

[MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]

PMID:20061081 PMID:23978332

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

catenin beta 1

multiple interactions

ISO

[MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

MK-886 promotes the reaction [Dronabinol results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

E2F transcription factor 1

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

early growth response 1

multiple interactions

EXP

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

epoxide hydrolase 2

multiple interactions

ISO

EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with MK-886] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased abundance of 5-hydroxy-6,8,11,14-eicosatetraenoic acid]]; EPHX2 gene mutant form promotes the reaction [MK-886 inhibits the reaction [Lipopolysaccharides results in increased expression of ALOX5 protein]]; MK-886 promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

coagulation factor III, tissue factor

multiple interactions

ISO

MK-886 inhibits the reaction [3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]; MK-886 inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased activity of F3 protein]]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid 2-hydroxylase

multiple interactions

ISO

MK-886 inhibits the reaction [Dronabinol results in increased expression of FA2H mRNA]; MK-886 promotes the reaction [Dronabinol results in increased expression of FA2H mRNA]

PMID:23535410 PMID:25291031

NCBI chr19:56,222,240...56,273,480
Ensembl chr19:56,222,242...56,273,623

G

interleukin 10

multiple interactions

ISO

MK-886 inhibits the reaction [Zymosan results in increased secretion of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 6

multiple interactions

ISO

MK-886 promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

lipoprotein lipase

multiple interactions

ISO

MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of LPL protein]; MK-886 inhibits the reaction [Plant Extracts results in increased expression of LPL mRNA]

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

leukotriene B4 receptor

multiple interactions

EXP

MK-886 binds to and results in decreased activity of LTB4R protein; MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde]

NCBI chr15:33,233,120...33,235,636
Ensembl chr15:33,232,820...33,235,637

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

ISO

MK-886 inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein]

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

matrix metallopeptidase 7

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

matrix metallopeptidase 9

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]

PMID:19837106 PMID:20061081

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

nitric oxide synthase 3

multiple interactions

ISO

[fulvestrant co-treated with MK-886] inhibits the reaction [resveratrol results in increased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

pyruvate dehydrogenase kinase 4

multiple interactions

ISO

MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein]

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

phospholipase A2 group 4A

multiple interactions

ISO

MK-886 inhibits the reaction [Histamine results in increased expression of PLA2G4A mRNA]

NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641

G

plasminogen activator, urokinase

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

DNA polymerase iota

decreases activity

ISO

MK-886 results in decreased activity of POLI protein

NCBI chr18:66,389,214...66,409,734
Ensembl chr18:66,364,236...66,409,819

G

DNA polymerase kappa

decreases activity

ISO

MK-886 results in decreased activity of POLK protein

NCBI chr 2:29,556,831...29,616,960
Ensembl chr 2:29,557,336...29,616,960

G

DNA polymerase mu

decreases activity

ISO

MK-886 results in decreased activity of POLM protein

NCBI chr14:84,921,039...84,930,649
Ensembl chr14:84,921,045...84,930,622

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression

ISO
EXP

[MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CDH1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] inhibits the reaction [perfluorooctanoic acid results in decreased expression of CTNNB1 protein]; [MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to perfluorooctanoic acid; MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [Plant Extracts results in increased activity of PPARA protein]; MK-886 promotes the reaction [Dronabinol results in increased expression of PPARA mRNA]
[MK-886 binds to and results in decreased activity of PPARA protein] which results in decreased susceptibility to palmidrol analog; MK-886 binds to and results in decreased activity of PPARA protein
MK-886 binds to and results in decreased activity of PPARA protein; MK-886 inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of PPARA protein]; MK-886 inhibits the reaction [perfluorooctanoic acid results in increased activity of PPARA protein]
MK-886 results in increased expression of PPARA mRNA

PMID:15899809 PMID:15975614 PMID:17047030 PMID:17558434 PMID:18292206 More...

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression
increases activity
affects localization

ISO

[Indomethacin co-treated with MK-886] affects the localization of PPARG protein; Indomethacin promotes the reaction [MK-886 results in increased activity of PPARG protein]
MK-886 results in increased expression of PPARG mRNA
MK-886 affects the localization of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

prostaglandin E synthase

decreases activity

ISO

MK-886 results in decreased activity of PTGES protein

PMID:20933508 PMID:25451575

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

RB transcriptional corepressor 1

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

MK-886 inhibits the reaction [pirinixic acid results in decreased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

retinoid X receptor alpha

increases expression
multiple interactions

ISO

MK-886 results in increased expression of RXRA mRNA
[MK-886 co-treated with Indomethacin] results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

S100 calcium binding protein B

multiple interactions

EXP

MK-886 inhibits the reaction [pirinixic acid affects the expression of S100B protein]

NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081

G

selectin P

multiple interactions

ISO

MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987

G

superoxide dismutase 2

multiple interactions

ISO

MK-886 promotes the reaction [SOD2 gene mutant form results in decreased abundance of Adenosine Triphosphate]; MK-886 promotes the reaction [SOD2 gene mutant form results in increased abundance of Lactic Acid]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

transcription factor Dp-1

multiple interactions

ISO

MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein]

NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996

G

tumor necrosis factor

multiple interactions

ISO

[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein; MK-886 inhibits the reaction [TNF protein results in decreased expression of APOA1 mRNA]; monascin inhibits the reaction [[Ovalbumin co-treated with MK-886] results in increased expression of TNF protein]

PMID:19883121 PMID:22381257

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

uncoupling protein 2

multiple interactions

EXP

MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 mRNA]; MK-886 inhibits the reaction [pirinixic acid results in increased expression of UCP2 protein]

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

4-nitrocatechol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

increases methylation

EXP
ISO

COMT protein results in increased methylation of 4-nitrocatechol

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases chemical synthesis
multiple interactions

EXP
ISO

CYP2E1 protein results in increased chemical synthesis of 4-nitrocatechol
[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; notopterol inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]
[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; daidzein inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; isobavachalcone inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; neobavaisoflavone inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; psoralidin inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]

PMID:31870919 PMID:32198085

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

ISO

azelastine inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; azelastine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
azelastine results in decreased activity of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetylcholinesterase

decreases activity

ISO

azelastine results in decreased activity of ACHE protein

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

collagen type I alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

collagen type VI alpha 1 chain

decreases expression

ISO

azelastine results in decreased expression of COL6A1 mRNA

NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,457...11,924,107

G

histamine receptor H 1

affects binding

ISO

azelastine binds to HRH1 protein

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

azelastine results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

solute carrier family 22 member 2

multiple interactions

ISO

azelastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions
increases activity

ISO

baicalein results in increased expression of ABCB1 protein
baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; baicalein inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; baicalein inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; baicalein promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]
baicalein results in increased activity of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

decreases activity

ISO

baicalein results in decreased activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of ACTA2 protein
baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

alpha-fetoprotein

affects binding

EXP

baicalein binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aryl hydrocarbon receptor

multiple interactions
affects response to substance
increases activity
increases expression

ISO

AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; baicalein binds to and results in increased activity of AHR protein
AHR protein affects the susceptibility to baicalein
baicalein results in increased activity of AHR protein
baicalein results in increased expression of AHR protein

PMID:14644660 PMID:17869316 PMID:22820424

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

ISO

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]]; baicalein inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

AKT serine/threonine kinase 1

decreases phosphorylation
affects binding
increases phosphorylation
multiple interactions

ISO

baicalein results in decreased phosphorylation of AKT1 protein
baicalein binds to AKT1 protein
baicalein results in increased phosphorylation of AKT1 protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of AKT1 mRNA]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]

PMID:18025287 PMID:22820424 PMID:36988316 PMID:38230788

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 12-lipoxygenase, 12S type

multiple interactions
decreases activity

ISO

baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
baicalein results in decreased activity of ALOX12 protein

PMID:17027136 PMID:23238474

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199

G

arachidonate 15-lipoxygenase

decreases activity

ISO

baicalein results in decreased activity of ALOX15 protein

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

amyloid beta precursor protein

multiple interactions

EXP

baicalein inhibits the reaction [APP protein binds to APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

arginase 1

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in decreased expression of ARG1 protein]

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

achaete-scute family bHLH transcription factor 3

affects expression

ISO

baicalein affects the expression of ASCL3 protein

NCBI chr 1:173,190,061...173,194,302
Ensembl chr 1:173,190,228...173,192,197

G

achaete-scute family bHLH transcription factor 4

affects expression

ISO

baicalein affects the expression of ASCL4 protein

NCBI chr 7:19,828,710...19,830,952
Ensembl chr 7:19,828,710...19,830,952

G

activating transcription factor 4

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF4 protein]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 5

increases expression
multiple interactions

EXP

baicalein results in increased expression of ATF5 protein
[Carbon Tetrachloride co-treated with baicalein] results in increased expression of ATF5 protein

NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183

G

activating transcription factor 6

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF6 protein]

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

activating transcription factor 7

multiple interactions

EXP

[Carbon Tetrachloride co-treated with baicalein] results in increased expression of ATF7 protein

NCBI chr 7:135,537,351...135,649,188
Ensembl chr 7:135,542,111...135,599,899

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of BAX protein modified form]; baicalein inhibits the reaction [Bleomycin results in increased expression of BAX protein]
baicalein results in increased expression of BAX protein

PMID:20850421 PMID:21457722 PMID:37783230

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]; baicalein inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]
baicalein results in decreased expression of BCL2 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of BCL2 protein]

PMID:20850421 PMID:33838155 PMID:37783230

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions
increases expression

EXP

[Carbon Tetrachloride co-treated with baicalein] results in increased expression of BECN1 protein
baicalein results in increased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

ISO

SB 203580 inhibits the reaction [baicalein results in decreased expression of BIRC5 protein]; wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 1

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions

ISO

5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP3 protein modified form]; baicalein inhibits the reaction [Bleomycin results in increased cleavage of CASP3 protein]

PMID:20850421 PMID:37783230

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CASP8 protein modified form]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

cyclin A1

decreases expression

EXP

baicalein results in decreased expression of CCNA1 protein

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin A2

decreases expression

ISO
EXP

baicalein results in decreased expression of CCNA2 protein

PMID:11513834 PMID:21457722

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

baicalein results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression
increases expression

ISO

Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]

PMID:19160421 PMID:21457722 PMID:22820424 PMID:24560969 PMID:36988316

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D2

decreases expression

EXP

baicalein results in decreased expression of CCND2 protein

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301

G

cyclin E1

decreases expression
increases expression

ISO
EXP

baicalein results in decreased expression of CCNE1 protein
baicalein results in increased expression of CCNE1 protein

PMID:11513834 PMID:24560969

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

CD163 molecule

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in decreased expression of CD163 mRNA]

NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146

G

Cd80 molecule

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

CD86 molecule

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361

G

cyclin-dependent kinase 1

decreases phosphorylation
decreases expression
multiple interactions

ISO
EXP

baicalein results in decreased phosphorylation of CDK1 protein
baicalein results in decreased expression of CDK1 protein
SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]

PMID:11513834 PMID:18025287

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

decreases expression

EXP

baicalein results in decreased expression of CDK2 protein

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

increases expression

ISO

baicalein results in increased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO
EXP

baicalein inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]
baicalein results in increased expression of CDKN1A protein

PMID:11513834 PMID:34624459

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 2B

increases expression

EXP

baicalein results in increased expression of CDKN2B protein

NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:109,114,322...109,134,855

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

baicalein results in decreased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

decreases expression

ISO

baicalein results in decreased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

CCAAT/enhancer binding protein gamma

decreases expression

ISO

baicalein results in decreased expression of CEBPG mRNA

NCBI chr 1:96,820,981...96,829,736
Ensembl chr 1:96,810,214...96,830,283

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

ISO

baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of CFLAR protein]

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

CF transmembrane conductance regulator

increases activity

ISO

baicalein results in increased activity of CFTR protein

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

collagen type I alpha 1 chain

multiple interactions

ISO

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]]; baicalein inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]

PMID:30201452 PMID:37783230

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

EXP

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

colony stimulating factor 2

decreases expression

ISO

baicalein results in decreased expression of CSF2 mRNA

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

catenin beta 1

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of CTNNB1 protein
STMN1 protein inhibits the reaction [baicalein results in decreased expression of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cytochrome c, somatic

multiple interactions

ISO

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of CYCS protein]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases expression
multiple interactions
increases chemical synthesis
decreases activity

ISO

baicalein results in increased expression of CYP1A1 protein
baicalein results in decreased expression of CYP1A1 mRNA
[CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CYP1A1 protein results in increased chemical synthesis of baicalein
baicalein results in decreased activity of CYP1A1 protein

PMID:12224597 PMID:14644660 PMID:18451504 PMID:19666078 PMID:21053930 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases chemical synthesis
multiple interactions

ISO

baicalein results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased chemical synthesis of baicalein
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein

PMID:19666078 PMID:21053930 PMID:29753067

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity
increases chemical synthesis
multiple interactions

ISO

baicalein results in decreased activity of CYP1B1 protein
CYP1B1 protein results in increased chemical synthesis of baicalein
[CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; baicalein binds to and results in decreased activity of CYP1B1 protein; baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA]

PMID:12224597 PMID:19666078 PMID:21053930 PMID:21482471

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

ISO

baicalein results in increased expression of CYP2B6 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

baicalein results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO

baicalein results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

baicalein results in decreased activity of CYP3A4 protein

PMID:21053930 PMID:29753067

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

diacylglycerol O-acyltransferase 1

decreases expression

ISO

baicalein results in decreased expression of DGAT1 protein

NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:110,098,906...110,115,016

G

delta like non-canonical Notch ligand 1

increases expression

ISO

baicalein results in increased expression of DLK1 mRNA

NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:134,192,518...134,200,529

G

epidermal growth factor

multiple interactions

ISO

baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
affects binding

ISO

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of EGFR mRNA]; baicalein inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of EGFR protein]
baicalein binds to EGFR protein

PMID:25625231 PMID:33838155 PMID:38230788

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 2

decreases expression

ISO

baicalein results in decreased expression of EGR2 mRNA

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

ETS transcription factor ELK1

multiple interactions

ISO

baicalein inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

erythropoietin

increases expression

ISO

baicalein results in increased expression of EPO mRNA

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases expression

ISO

baicalein results in decreased expression of and results in decreased phosphorylation of ERBB2 protein
baicalein results in decreased expression of ERBB2 mRNA

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 1

affects binding
multiple interactions

ISO

baicalein binds to ESR1 protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in decreased expression of ESR1 mRNA]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

fatty acid binding protein 4

decreases expression

ISO

baicalein results in decreased expression of FABP4 protein

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fatty acid synthase

decreases expression

ISO

baicalein results in decreased expression of FASN protein

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibronectin 1

multiple interactions

ISO

baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

galactosidase, beta 1

multiple interactions

ISO

baicalein inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

GLI family zinc finger 1

decreases expression

ISO

baicalein results in decreased expression of GLI1 mRNA; baicalein results in decreased expression of GLI1 protein

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540

G

glycerol-3-phosphate acyltransferase 3

decreases expression

ISO

baicalein results in decreased expression of GPAT3 protein

NCBI chr14:9,018,762...9,072,552

G

glutathione peroxidase 4

affects expression
multiple interactions

ISO

baicalein affects the expression of GPX4 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]

PMID:36055377 PMID:37354967

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

gasdermin D

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

glycogen synthase kinase 3 beta

decreases phosphorylation
multiple interactions

ISO

baicalein results in decreased phosphorylation of GSK3B protein
baicalein inhibits the reaction [Mitomycin results in increased phosphorylation of GSK3B protein]

PMID:22820424 PMID:34624459 PMID:36988316

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

hes family bHLH transcription factor 1

multiple interactions
increases expression

ISO

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hes-related family bHLH transcription factor with YRPW motif 1

multiple interactions
increases expression

ISO

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]

NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:95,002,943...95,007,624

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

ISO

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]

NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:28,641,057...28,651,187

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

baicalein results in decreased degradation of and results in increased expression of HIF1A protein modified form
baicalein results in increased expression of HIF1A mRNA; baicalein results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

increases expression
multiple interactions

ISO

baicalein results in increased expression of HMOX1 mRNA; baicalein results in increased expression of HMOX1 protein
baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of HMOX1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]
Hemin promotes the reaction [baicalein results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]

PMID:14563492 PMID:37354967

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases activity

ISO

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein]

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

insulin-like growth factor 1

multiple interactions

ISO

baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 10

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO

baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of IL1B protein]

PMID:22369883 PMID:38230788 PMID:38664950

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 2

multiple interactions
increases secretion

ISO

baicalein promotes the reaction [Glucose results in increased secretion of INS protein]
baicalein results in increased secretion of INS protein

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects binding

ISO

baicalein inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of JUN mRNA]
baicalein binds to JUN protein

PMID:17458902 PMID:38230788

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

KLF transcription factor 2

increases expression

ISO

baicalein results in increased expression of KLF2 mRNA

NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,555,136...17,557,768

G

KLF transcription factor 5

decreases expression

ISO

baicalein results in decreased expression of KLF5 mRNA

NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262

G

lipin 1

decreases expression

ISO

baicalein results in decreased expression of LPIN1 protein

NCBI chr 6:45,039,110...45,145,845
Ensembl chr 6:45,041,522...45,145,991

G

mitogen activated protein kinase 1

multiple interactions
affects binding
decreases phosphorylation

ISO

baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of MAPK1 mRNA]; baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK1 protein]
baicalein binds to MAPK1 protein
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK1 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]

PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155 PMID:38230788

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

ISO

baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of MAPK3 protein]
baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of MAPK3 protein modified form]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]

PMID:10718847 PMID:20850421 PMID:31811862 PMID:33838155

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

microRNA 1224

increases expression

ISO

baicalein results in increased expression of MIR1224 mRNA

NCBI chr11:93,811,291...93,811,375

G

microRNA 21

multiple interactions

ISO

baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr10:71,902,600...71,902,691

G

microRNA 322

increases expression

ISO

baicalein results in increased expression of MIR424 mRNA

NCBI chr X:137,726,147...137,726,241

G

matrix metallopeptidase 2

decreases activity
multiple interactions

ISO

baicalein results in decreased activity of MMP2 protein
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]

PMID:21803068 PMID:22369883 PMID:36988316

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases expression
decreases activity

ISO

baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; STMN1 protein inhibits the reaction [baicalein results in decreased expression of MMP9 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
baicalein results in decreased activity of MMP9 protein

PMID:19804834 PMID:21803068 PMID:22369883 PMID:38317500

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

ISO

baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mannose receptor, C type 1

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in decreased expression of MRC1 protein]

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

baicalein results in decreased phosphorylation of and results in decreased activity of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

N-acetyltransferase 1

decreases expression

ISO

baicalein results in decreased expression of NAT1 mRNA; baicalein results in decreased expression of NAT1 protein

NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527

G

nuclear factor kappa B subunit 1

decreases localization

ISO

baicalein results in decreased localization of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation

ISO

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of NFKBIA protein]
baicalein results in decreased phosphorylation of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

decreases phosphorylation

ISO

baicalein results in decreased phosphorylation of NFKBIB protein

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO

baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Hemin promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; tin protoporphyrin IX inhibits the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]
baicalein results in decreased expression of NOS2 protein

PMID:14563492 PMID:20850421 PMID:22369883 PMID:38664950

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

notch receptor 1

increases activity
increases expression

ISO

baicalein results in increased activity of NOTCH1 protein
baicalein results in increased expression of NOTCH1 mRNA

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

nuclear receptor subfamily 1, group I, member 3

affects localization

ISO

baicalein affects the localization of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

proliferating cell nuclear antigen

multiple interactions
decreases expression

ISO

STMN1 protein inhibits the reaction [baicalein results in decreased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphatidylinositol 3-kinase, catalytic subunit type 3

multiple interactions

EXP

[Carbon Tetrachloride co-treated with baicalein] results in increased expression of PIK3C3 protein

NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

affects binding
multiple interactions

ISO

baicalein binds to PIK3CA protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of PIK3CA mRNA]

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

pyruvate kinase M1/2

increases activity

ISO

baicalein results in increased activity of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase A2 group IIA

multiple interactions

ISO

baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK1 protein]; baicalein inhibits the reaction [PLA2G2A protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

plasminogen activator, urokinase

decreases activity

ISO

baicalein results in decreased activity of PLAU protein

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA]

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

baicalein results in decreased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase C, alpha

decreases phosphorylation

ISO

baicalein results in decreased phosphorylation of PRKCA protein

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA]; baicalein inhibits the reaction [PLA2G2A protein results in increased expression of PTGS2 protein]; baicalein inhibits the reaction [Polymyxin B results in increased expression of PTGS2 protein]

PMID:19804834 PMID:22369883 PMID:31811862 PMID:37354967

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

glycogen phosphorylase B

decreases activity

ISO

baicalein results in decreased activity of PYGB protein

NCBI chr 3:160,072,141...160,118,930
Ensembl chr 3:160,072,115...160,123,961

G

glycogen phosphorylase L

decreases activity

ISO

baicalein results in decreased activity of PYGL protein

NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269

G

RB transcriptional corepressor 1

multiple interactions
decreases phosphorylation

ISO

AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein]

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases phosphorylation
affects localization
decreases localization

ISO

baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
baicalein results in decreased phosphorylation of RELA protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]; NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]
baicalein results in decreased localization of RELA protein

PMID:20850421 PMID:21803068 PMID:22369883 PMID:29481769 PMID:33838155

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ribosomal protein S6 kinase B1

multiple interactions

ISO

baicalein results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

SH3 domain containing GRB2 like 1, endophilin A2

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of SH3GL1 mRNA; baicalein results in decreased expression of SH3GL1 protein
MIR3663 mRNA promotes the reaction [baicalein results in decreased expression of SH3GL1 protein]

NCBI chr 9:929,459...956,922
Ensembl chr 9:928,563...956,890

G

sirtuin 1

multiple interactions

ISO

baicalein inhibits the reaction [Polymyxin B results in decreased expression of SIRT1 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of GPX4 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of HMOX1 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 22 member 6

decreases activity

ISO

baicalein results in decreased activity of SLC22A6 protein

NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311

G

solute carrier family 7 member 11

multiple interactions

ISO

baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in decreased expression of SLC7A11 protein]]

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

synuclein alpha

multiple interactions

ISO

baicalein inhibits the reaction [SNCA protein binds to SNCA protein]
baicalein inhibits the reaction [Rotenone promotes the reaction [SNCA protein binds to SNCA protein]]; baicalein inhibits the reaction [Rotenone results in increased expression of SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

sprouty RTK signaling antagonist 1

multiple interactions

ISO

baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:122,484,355...122,492,956

G

SRC proto-oncogene, non-receptor tyrosine kinase

affects binding
multiple interactions

ISO

baicalein binds to SRC protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of SRC mRNA]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

sterol regulatory element binding transcription factor 1

decreases expression

ISO

baicalein results in decreased expression of SREBF1 protein

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

signal transducer and activator of transcription 3

multiple interactions

ISO

baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

stathmin 1

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of STMN1 protein
STMN1 protein inhibits the reaction [baicalein results in decreased expression of CTNNB1 protein]; STMN1 protein inhibits the reaction [baicalein results in decreased expression of MMP9 protein]; STMN1 protein inhibits the reaction [baicalein results in decreased expression of PCNA protein]; STMN1 protein inhibits the reaction [baicalein results in decreased expression of WNT3A protein]

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842

G

transforming growth factor, beta 1

multiple interactions

EXP
ISO

baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
5-hydroxydecanoic acid inhibits the reaction [baicalein inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]]
baicalein inhibits the reaction [TGFB1 protein results in decreased expression of SPRY1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; baicalein inhibits the reaction [TGFB1 protein results in increased expression of MIR21 mRNA]; baicalein inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; MIR21 mRNA inhibits the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]; SPRY1 protein affects the reaction [baicalein inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]]

PMID:19474275 PMID:30201452 PMID:37783230

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

multiple interactions

ISO

baicalein inhibits the reaction [Rotenone results in decreased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of TNF protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of TNF protein]
baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; baicalein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:20850421 PMID:22369883 PMID:38230788 PMID:38664950

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases expression
affects binding
multiple interactions

ISO
EXP

baicalein results in increased expression of TP53 protein
baicalein binds to TP53 protein
baicalein inhibits the reaction [Cholesterol, LDL analog results in increased expression of TP53 mRNA]; baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]; SIRT1 protein promotes the reaction [baicalein inhibits the reaction [Polymyxin B results in increased acetylation of TP53 protein]]

PMID:11513834 PMID:21457722 PMID:37354967 PMID:38230788

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

vascular endothelial growth factor A

decreases expression

ISO

baicalein results in decreased expression of VEGFA protein

PMID:16638750 PMID:36988316

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

Wnt family member 3A

decreases expression
multiple interactions

ISO

baicalein results in decreased expression of WNT3A protein
STMN1 protein inhibits the reaction [baicalein results in decreased expression of WNT3A protein]

NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,533,734...44,577,919

G

X-box binding protein 1

multiple interactions

EXP

baicalein inhibits the reaction [Carbon Tetrachloride results in increased expression of XBP1 protein]

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

xanthine dehydrogenase

multiple interactions

ISO

baicalein inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-linked inhibitor of apoptosis

multiple interactions

ISO

baicalein inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of XIAP protein]

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

decreases response to substance

ISO

ALB protein results in decreased susceptibility to benoxaprofen

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

arachidonate 12-lipoxygenase, 12S type

decreases activity

EXP

benoxaprofen results in decreased activity of ALOX12 protein

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199

G

arachidonate 5-lipoxygenase

multiple interactions
decreases activity

ISO
EXP

[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [benoxaprofen results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid

PMID:2724698 PMID:2849922 PMID:3020588 PMID:3928952

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

EXP
ISO

benoxaprofen results in increased expression of CYP1A1 protein
benoxaprofen results in decreased activity of CYP1A1 protein

PMID:2069584 PMID:33814510

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

EXP

benoxaprofen results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

benoxaprofen results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

EXP

benoxaprofen results in increased expression of CYP4A1 protein

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

EXP

benoxaprofen results in increased expression of EHHADH protein

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662

G

glucuronidase, beta

increases secretion

ISO

benoxaprofen results in increased secretion of GUSB protein

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

luteinizing hormone subunit beta

multiple interactions

EXP

benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; benoxaprofen inhibits the reaction [LHB protein results in increased abundance of Testosterone]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

UDP glucuronosyltransferase 1 family, polypeptide A2

affects response to substance

ISO

UGT1A3 affects the susceptibility to benoxaprofen

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

affects response to substance

ISO

UGT1A9 affects the susceptibility to benoxaprofen

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B7

affects response to substance
increases glucuronidation

ISO

UGT2B7 affects the susceptibility to benoxaprofen
UGT2B7 protein alternative form results in increased glucuronidation of benoxaprofen

PMID:8423545 PMID:17880178

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 1

decreases activity
multiple interactions

ISO

Benzoic Acid analog results in decreased activity of ACP1 protein
Benzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]

NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:53,233,948...53,251,959

G

aldo-keto reductase family 1 member B1

increases expression

ISO

Benzoic Acid results in increased expression of AKR1B1 mRNA

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B10

increases expression

ISO

Benzoic Acid results in increased expression of AKR1B10 mRNA

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C1

increases expression

ISO

Benzoic Acid results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C3

increases expression

ISO

Benzoic Acid results in increased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

butyrylcholinesterase

increases abundance
increases chemical synthesis
multiple interactions

ISO

BCHE protein mutant form results in increased abundance of Benzoic Acid
BCHE protein mutant form results in increased chemical synthesis of Benzoic Acid
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of Benzoic Acid
[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid

PMID:25814464 PMID:30080993

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BCL2 promoter]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

baculoviral IAP repeat-containing 5

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BIRC5 promoter]

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

catalase

multiple interactions
decreases activity

ISO

Quercetin inhibits the reaction [Benzoic Acid results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

multiple interactions

ISO

Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

cyclin D1

multiple interactions
decreases expression

ISO

Benzoic Acid analog results in decreased activity of [CCND1 protein binds to CDK4 protein]
Benzoic Acid analog results in decreased expression of CCND1 protein

PMID:10403840 PMID:26088127

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase 4

multiple interactions

ISO

Benzoic Acid analog results in decreased activity of [CCND1 protein binds to CDK4 protein]

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

collagen type II alpha 1 chain

multiple interactions

EXP

[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Benzoic Acid

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

ISO

[Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

epidermal growth factor

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]; Benzoic Acid analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

Eph receptor A4

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [Adenosine Diphosphate results in increased phosphorylation of EPHA4 protein]; Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased phosphorylation of EPHA4 protein]

NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:86,263,982...86,406,755

G

ferrochelatase

increases expression

ISO

Benzoic Acid results in increased expression of FECH mRNA

NCBI chr18:60,215,325...60,248,525
Ensembl chr18:60,215,325...60,249,546

G

FOS like 1, AP-1 transcription factor subunit

increases expression

ISO

Benzoic Acid results in increased expression of FOSL1 protein

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

ferritin light chain 1

increases expression

ISO

Benzoic Acid results in increased expression of FTL mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

glucose-6-phosphate dehydrogenase

increases expression

ISO

Benzoic Acid results in increased expression of G6PD mRNA

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutamate-cysteine ligase, catalytic subunit

increases expression

ISO

Benzoic Acid results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

Benzoic Acid results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

increases activity

EXP

Benzoic Acid results in increased activity of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

increases expression

ISO

Benzoic Acid results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 1

increases activity

ISO

Benzoic Acid results in increased activity of GSTA1 protein mutant form

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

heme oxygenase 1

increases expression

ISO

Benzoic Acid results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 12B

multiple interactions

ISO

Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 1 alpha

increases expression
increases secretion

ISO

Benzoic Acid results in increased expression of IL1A mRNA
Benzoic Acid results in increased secretion of IL1A protein

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 receptor-like 1

increases expression

ISO

Benzoic Acid results in increased expression of IL1RL1 protein

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 4 induced 1

decreases activity

ISO

Benzoic Acid results in decreased activity of IL4I1 protein

NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:104,435,981...104,461,053

G

interleukin 6

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin receptor

increases phosphorylation

ISO

Benzoic Acid analog results in increased phosphorylation of INSR protein

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

MAF bZIP transcription factor G

increases expression

ISO

Benzoic Acid results in increased expression of MAFG mRNA

NCBI chr10:106,401,633...106,410,159

G

malic enzyme 1

increases expression

ISO

Benzoic Acid results in increased expression of ME1 mRNA

NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275

G

myeloperoxidase

increases activity

ISO

Benzoic Acid results in increased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallothionein 1A

increases expression

ISO

Benzoic Acid results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

increases expression

ISO

Benzoic Acid results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

ISO

[MYC protein results in increased expression of SLC16A1 protein] which results in increased import of Benzoic Acid
Benzoic Acid analog results in decreased expression of MYC protein

PMID:19239227 PMID:26088127

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nitric oxide synthase 2

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [STAT3 protein binds to NOS2 promoter]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

ISO

Benzoic Acid results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

NAD(P)H quinone dehydrogenase 1

increases expression

ISO

Benzoic Acid results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

platelet factor 4

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

phosphogluconate dehydrogenase

increases expression

ISO

Benzoic Acid results in increased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

prostaglandin reductase 1

increases expression

ISO

Benzoic Acid results in increased expression of PTGR1 mRNA

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases activity

ISO

Benzoic Acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]
Benzoic Acid results in decreased activity of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions
decreases activity

ISO

Benzoic Acid analog inhibits the reaction [PTPN1 protein results in increased hydrolysis of nitrophenylphosphate]
Benzoic Acid analog results in decreased activity of PTPN1 protein

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

G

protein tyrosine phosphatase, non-receptor type 2

multiple interactions
decreases activity

ISO

Benzoic Acid analog inhibits the reaction [PTPN2 protein results in increased hydrolysis of nitrophenylphosphate]
Benzoic Acid analog results in decreased activity of PTPN2 protein

NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481

G

solute carrier family 15 member 1

affects binding

ISO

Benzoic Acid analog binds to SLC15A1 protein

NCBI chr15:104,944,461...104,991,316
Ensembl chr15:104,944,463...104,989,369

G

solute carrier family 16 member 1

multiple interactions
increases transport
increases import
increases export
increases uptake

ISO
EXP

[MYC protein results in increased expression of SLC16A1 protein] which results in increased import of Benzoic Acid; Benzoic Acid inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]; morin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; Quercetin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]; silybin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
SLC16A1 protein results in increased transport of Benzoic Acid
SLC16A1 protein results in increased import of Benzoic Acid
SLC16A1 protein results in increased export of Benzoic Acid
Acetic Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Butyric Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Foscarnet inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; mandelic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; propionic acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]; Protons inhibits the reaction [SLC16A1 protein results in increased export of Benzoic Acid]; Protons promotes the reaction [SLC16A1 protein results in increased import of Benzoic Acid]; Salicylic Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid]

PMID:10579682 PMID:10714609 PMID:15804185 PMID:17976262 PMID:19239227

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 22 member 7

multiple interactions

ISO
EXP

[Orotic Acid co-treated with Benzoic Acid] promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]; Benzoic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid]

NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681

G

solute carrier family 4 member 2

multiple interactions
increases uptake

ISO

4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]; Bicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]; Chlorides inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid]

NCBI chr 4:11,628,860...11,646,961
Ensembl chr 4:11,628,862...11,645,402

G

sulfiredoxin 1

increases expression

ISO

Benzoic Acid results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765

G

signal transducer and activator of transcription 3

multiple interactions

ISO

Benzoic Acid analog inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BCL2 promoter]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to BIRC5 promoter]; Benzoic Acid analog inhibits the reaction [STAT3 protein binds to NOS2 promoter]; Benzoic Acid analog results in decreased phosphorylation of and results in decreased activity of STAT3 protein
Benzoic Acid analog inhibits the reaction [EGF protein promotes the reaction [STAT3 protein binds to EGFR protein]]; Benzoic Acid analog inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; Benzoic Acid analog results in decreased phosphorylation of and results in decreased activity of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor necrosis factor

multiple interactions

ISO

Benzoic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 1

increases expression

ISO

Benzoic Acid results in increased expression of TXN mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin reductase 1

increases expression

ISO

Benzoic Acid results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

vascular endothelial growth factor A

increases expression

ISO

Benzoic Acid results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

increases expression
multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased expression of ATF4 mRNA
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

BCL2, apoptosis regulator

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein; [1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased nitrosation of and results in increased ubiquitination of and results in increased degradation of BCL2 protein] which results in increased susceptibility to Chromates

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

baculoviral IAP repeat-containing 5

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of BIRC5 protein]

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

caspase 3

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caveolin 1

decreases expression

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased expression of CAV1 protein

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

cyclin D1

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of CCND1 protein]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

Cd28 molecule

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]

NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:69,545,326...69,689,192

G

cadherin 1

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in increased expression of CDH1 protein]

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

CCAAT/enhancer binding protein beta

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of CEBPB protein alternative form]

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

claudin 5

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of CLDN5 protein]

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

catenin beta 1

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in increased expression of DDIT3 mRNA
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of DDIT3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA]

PMID:21703327 PMID:30482226

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

glycogen synthase kinase 3 beta

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of MYC protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

prostaglandin I2 synthase

decreases activity

EXP

cPTIO decreases activity of Ptgis protein in the aorta

RGD

NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650

G

snail family transcriptional repressor 1

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of SNAI1 protein]

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of SNAI2 protein]

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

TNF superfamily member 10

decreases response to substance
multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole results in decreased susceptibility to TNFSF10 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]

NCBI chr 2:112,136,550...112,155,903

G

tribbles pseudokinase 3

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitroprusside results in increased expression of TRIB3 protein]

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

vimentin

multiple interactions

ISO

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate results in decreased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

cis-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acetylcholinesterase

multiple interactions
decreases activity

EXP

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

ATP citrate lyase

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

arachidonate 15-lipoxygenase

multiple interactions
decreases activity

ISO

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

arachidonate 5-lipoxygenase

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]
caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

amyloid beta precursor protein

multiple interactions

ISO

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

arginase 1

decreases activity

ISO

caffeic acid results in decreased activity of ARG1 protein

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

ATPase H+ transporting V0 subunit D2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

caspase 3

multiple interactions

ISO
EXP

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions
increases activity

EXP
ISO

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine receptor 1

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374

G

C-C motif chemokine receptor 2

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

C-C motif chemokine receptor 4

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642

G

Cd4 molecule

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461

G

Cd68 molecule

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

cell division cycle 20

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cyclin dependent kinase 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

choline O-acetyltransferase

multiple interactions

ISO

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

catechol-O-methyltransferase

increases methylation

ISO

COMT protein results in increased methylation of caffeic acid

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

corticotropin releasing hormone

multiple interactions

EXP

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

cardiotrophin 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

cathepsin B

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

death-associated protein

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

dihydropyrimidinase-like 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

endothelin 1

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

early growth response 1

multiple interactions

ISO

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

engulfment and cell motility 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 3:174,442,965...174,716,723
Ensembl chr 3:174,442,965...174,480,459

G

Ets2 repressor factor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 1:89,957,760...89,966,213
Ensembl chr 1:89,957,760...89,966,213

G

coagulation factor III, tissue factor

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid synthase

decreases expression
multiple interactions

ISO

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:120,507,689...120,609,004

G

Fms related receptor tyrosine kinase 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645

G

glucose-6-phosphate dehydrogenase

decreases activity

ISO

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

galactosidase, beta 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

glutaminase

increases expression

ISO

caffeic acid results in increased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase mu 1

decreases activity

EXP

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases activity

EXP

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

decreases activity

EXP

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glucuronidase, beta

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

EXP

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125

G

hepatitis A virus cellular receptor 2

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr10:31,383,801...31,415,334
Ensembl chr10:31,383,925...31,413,872

G

hes family bHLH transcription factor 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

holocarboxylase synthetase

decreases activity

ISO

caffeic acid results in decreased activity of HLCS protein

NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

ISO

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heat shock protein 90 beta family member 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family E (Hsp10) member 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

interferon gamma

increases expression
multiple interactions

ISO
EXP

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

decreases expression

ISO

caffeic acid results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO
EXP

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

increases expression

ISO

caffeic acid results in increased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 21 receptor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 1:189,598,682...189,626,340
Ensembl chr 1:189,598,558...189,626,342

G

interleukin 4

decreases expression

ISO

caffeic acid results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

increases expression
multiple interactions

ISO
EXP

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869 PMID:28299617

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinesin family member 15

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 8:131,479,340...131,550,209
Ensembl chr 8:131,479,337...131,550,202

G

kinesin family member 20B

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:241,840,987...241,896,451

G

kinesin family member 2C

multiple interactions

ISO

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

monoamine oxidase A

decreases activity

ISO

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases activity

ISO

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 5

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373

G

mitogen activated protein kinase 1

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitofusin 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

microsomal glutathione S-transferase 1

increases activity

EXP

caffeic acid results in increased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrial ribosomal protein L45

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr10:82,805,039...82,816,862
Ensembl chr10:82,804,874...82,816,139

G

mitochondrial ribosome recycling factor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 3:39,884,530...39,941,317
Ensembl chr 3:39,884,359...39,967,397

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

ISO

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

norrin cystine knot growth factor NDP

increases expression

ISO

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:8,379,569...8,404,019
Ensembl chr X:8,379,569...8,406,802

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

ISO

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

5' nucleotidase, ecto

multiple interactions
decreases activity

EXP

caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

programmed cell death 10

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 2:162,602,516...162,644,690
Ensembl chr 2:162,602,516...162,644,612

G

phosphogluconate dehydrogenase

decreases activity

ISO

caffeic acid results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ISO

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

polo-like kinase 1

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:125,730,460...125,748,892

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

peroxiredoxin 5

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

pentraxin 3

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

stearoyl-CoA desaturase

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

serpin family E member 1

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sideroflexin 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr 1:269,962,527...269,984,849
Ensembl chr 1:269,962,535...269,984,836

G

solute carrier family 2 member 2

increases expression

ISO

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 4

increases expression

ISO

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 5 member 1

increases expression

ISO

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

synuclein alpha

multiple interactions

ISO

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

serine/threonine kinase 32A

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:35,509,791...35,620,421
Ensembl chr18:35,509,982...35,628,985

G

sulfotransferase family 1A member 1

increases sulfation

ISO

SULT1A1 protein results in increased sulfation of caffeic acid

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1C member 2A

increases sulfation

ISO

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

tumor necrosis factor

increases expression
multiple interactions

ISO
EXP

caffeic acid results in increased expression of TNF mRNA
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

affects expression
multiple interactions

ISO

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tyrosinase

increases oxidation
multiple interactions

ISO

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin-conjugating enzyme E2C

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

UDP glucuronosyltransferase family 1 member A1

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

ISO

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

ISO

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

ISO

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

G

vascular endothelial growth factor A

decreases secretion

ISO

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

xanthine dehydrogenase

multiple interactions

ISO

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha 1,4-galactosyltransferase

multiple interactions

ISO

Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]

NCBI chr 7:116,248,571...116,272,917
Ensembl chr 7:116,247,880...116,273,171

G

alanyl-tRNA synthetase 1

decreases expression

ISO

Curcumin results in decreased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily A member 1

multiple interactions

ISO

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases response to substance
decreases expression
affects response to substance

ISO

[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein
ABCB1 protein results in decreased susceptibility to Curcumin
Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
ABCB1 affects the susceptibility to Curcumin

PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 More...

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP-binding cassette, sub-family B member 1B

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]
Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567

G

ATP binding cassette subfamily C member 1

decreases activity
decreases expression

ISO

Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA

PMID:15885658 PMID:16021489 PMID:26409325

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 2

decreases activity
multiple interactions

ISO

Curcumin results in decreased activity of ABCC2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein

PMID:15885658 PMID:35243748

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

multiple interactions

ISO

[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

ATP binding cassette subfamily G member 1

increases expression

ISO

Curcumin results in increased expression of ABCG1 mRNA

PMID:16713233 PMID:21594647

NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563

G

ATP binding cassette subfamily G member 2

multiple interactions
decreases expression
increases expression

ISO

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin results in decreased expression of ABCG2 mRNA

PMID:17077187 PMID:33539684

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acetyl-CoA carboxylase alpha

increases phosphorylation
decreases expression
affects expression
multiple interactions

ISO
EXP

Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]

PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acetyl-CoA carboxylase beta

multiple interactions

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein]

NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214

G

angiotensin I converting enzyme

multiple interactions

EXP

Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein]

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

angiotensin converting enzyme 2

multiple interactions
affects binding

EXP
ISO

Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]
Curcumin binds to ACE2 protein

PMID:26648693 PMID:34138966

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

acetylcholinesterase

multiple interactions
decreases activity

ISO
EXP

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]

PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 More...

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

atypical chemokine receptor 3

increases expression

ISO

Curcumin results in increased expression of ACKR3 mRNA

NCBI chr 9:98,247,300...98,258,877
Ensembl chr 9:98,246,605...98,260,214

G

ATP citrate lyase

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

aconitase 2

multiple interactions

EXP

Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein]

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

ISO

Curcumin inhibits the reaction [Firemaster BP-6 results in increased expression of ACSL4 protein]

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:110,739,648...110,803,261

G

actin alpha 2, smooth muscle

decreases expression
multiple interactions

EXP
ISO

Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]]

PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 More...

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

ADAM metallopeptidase domain 17

multiple interactions

ISO

Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]

NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344

G

ADAM metallopeptidase with thrombospondin type 1 motif, 4

increases expression

ISO

Curcumin results in increased expression of ADAMTS4 mRNA

NCBI chr13:86,203,011...86,212,500
Ensembl chr13:86,202,642...86,212,514

G

adenylate cyclase 9

decreases expression

ISO

Curcumin results in decreased expression of ADCY9 mRNA

NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,645,282...11,765,792

G

adhesion G protein-coupled receptor E1

decreases expression

ISO

Curcumin results in decreased expression of ADGRE1 mRNA

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions
affects expression

ISO
EXP

Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]

PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

adenosine A2a receptor

multiple interactions

ISO

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]

NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

anterior gradient 2, protein disulphide isomerase family member

decreases expression

ISO

Curcumin results in decreased expression of AGR2 mRNA

NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:58,435,908...58,456,677

G

angiotensinogen

multiple interactions

EXP
ISO

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]

PMID:26612707 PMID:26648693 PMID:31820278

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

angiotensin II receptor, type 2

multiple interactions

EXP

Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:116,913,656...116,918,745

G

aryl hydrocarbon receptor

multiple interactions
affects binding
increases degradation

ISO

AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]

PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

adenylate kinase 1

multiple interactions

ISO

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein

NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:36,310,197...36,320,757

G

A-kinase anchoring protein 6

increases expression
multiple interactions

ISO

Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]

PMID:18200517 PMID:18421014

NCBI chr 6:75,919,350...76,359,667
Ensembl chr 6:75,919,513...76,355,036

G

aldo-keto reductase family 1 member B1

increases expression
multiple interactions
increases activity

ISO
EXP

Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein

PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B15

increases expression

EXP

Curcumin results in increased expression of AKR1B8 mRNA

NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
affects phosphorylation
decreases expression
increases expression
increases phosphorylation
decreases activity

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; MIR206 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin results in decreased activity of AKT1 protein

PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

multiple interactions
decreases phosphorylation
decreases expression

ISO

4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA

PMID:23452621 PMID:26409325 PMID:36640941

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

AKT serine/threonine kinase 3

multiple interactions
decreases expression
decreases phosphorylation

ISO

ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]
Curcumin results in decreased expression of AKT3 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]

PMID:36640941 PMID:37471645

NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020

G

aminolevulinate dehydratase

multiple interactions

EXP
ISO

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [Bortezomib results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]

PMID:22704994 PMID:23292317 PMID:25352650

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

5'-aminolevulinate synthase 1

increases expression

EXP

Curcumin results in increased expression of ALAS1 mRNA

NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642

G

albumin

multiple interactions

EXP

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]]

PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 More...

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

activated leukocyte cell adhesion molecule

decreases expression

ISO

Curcumin results in decreased expression of ALCAM mRNA

NCBI chr11:61,804,932...62,005,250
Ensembl chr11:61,805,049...62,006,876

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions
decreases expression

ISO

[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldolase, fructose-bisphosphate A

decreases expression

ISO

Curcumin results in decreased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211

G

aldolase, fructose-bisphosphate C

decreases expression

ISO

Curcumin results in decreased expression of ALDOC mRNA

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133

G

arachidonate 5-lipoxygenase

multiple interactions
decreases activity

EXP

[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

autocrine motility factor receptor

increases expression

ISO

Curcumin results in increased expression of AMFR mRNA; Curcumin results in increased expression of AMFR protein

NCBI chr19:11,002,451...11,038,182
Ensembl chr19:11,002,101...11,038,364

G

adenosine monophosphate deaminase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein]

NCBI chr 2:193,287,219...193,308,446
Ensembl chr 2:193,287,265...193,308,443

G

adenosine monophosphate deaminase 3

increases expression

EXP

Curcumin results in increased expression of AMPD3 mRNA

NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:174,294,867...174,364,608

G

ankyrin repeat domain 37

decreases expression

ISO

Curcumin results in decreased expression of ANKRD37 mRNA

NCBI chr16:53,001,487...53,004,545
Ensembl chr16:52,994,740...53,004,545

G

ankyrin repeat domain containing 50

decreases expression

ISO

Curcumin results in decreased expression of ANKRD50 mRNA

NCBI chr 2:123,394,311...123,428,788
Ensembl chr 2:123,396,606...123,427,340

G

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

decreases expression

ISO

Curcumin results in decreased expression of ANKZF1 mRNA

NCBI chr 9:84,136,862...84,143,830
Ensembl chr 9:84,136,862...84,145,091

G

amine oxidase, copper containing 1

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein]
Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein]

PMID:20885979 PMID:35817260

NCBI chr 4:79,143,126...79,162,705
Ensembl chr 4:79,143,126...79,162,704

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]

PMID:17277231 PMID:20869986

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

APC regulator of WNT signaling pathway

decreases expression

ISO

Curcumin results in decreased expression of APC mRNA

NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022

G

apolipoprotein E

affects expression

ISO

Curcumin affects the expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855

G

amyloid beta precursor protein

multiple interactions
increases expression

ISO
EXP

Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
Curcumin results in increased expression of APP mRNA

PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 3 (Gill blood group)

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]

NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685

G

aquaporin 9

increases expression

ISO

Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein

NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240

G

androgen receptor

multiple interactions
increases expression
decreases activity
decreases expression

ISO

[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein

PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

Rho GTPase activating protein 24

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA]

NCBI chr14:7,105,200...7,488,437
Ensembl chr14:7,105,200...7,528,950

G

Rho GTPase activating protein 30

decreases expression

ISO

Curcumin results in decreased expression of ARHGAP30 mRNA

NCBI chr13:86,354,448...86,376,552
Ensembl chr13:86,354,547...86,376,888

G

Rho GDP dissociation inhibitor beta

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA]

NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases degradation
decreases expression

ISO

Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein

PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

activating transcription factor 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA]

NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:133,241,197...133,283,485

G

activating transcription factor 2

decreases expression

ISO

Curcumin analog results in decreased expression of ATF2 mRNA

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

activating transcription factor 3

increases expression

ISO

Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein

PMID:15713895 PMID:18555241 PMID:18719366

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

activating transcription factor 4

multiple interactions
decreases expression

ISO

ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]
ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739

G

activating transcription factor 6

increases expression

ISO

Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA

PMID:21793155 PMID:29723631

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

autophagy related 4B, cysteine peptidase

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of ATG4B protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein]

NCBI chr 9:101,729,772...101,761,456
Ensembl chr 9:101,726,782...101,761,622

G

autophagy related 5

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of ATG5 protein
Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

ATM serine/threonine kinase

multiple interactions
increases phosphorylation

ISO

[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein

PMID:19401701 PMID:21134073

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

aurora kinase A

decreases expression

ISO

Curcumin analog results in decreased expression of AURKA mRNA

NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771

G

aurora kinase B

decreases expression

ISO

Curcumin analog results in decreased expression of AURKB mRNA

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:54,242,850...54,252,285

G

axin 1

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA

NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092

G

Axl receptor tyrosine kinase

multiple interactions

ISO

Curcumin inhibits the reaction [Cuprizone results in increased expression of AXL protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AXL protein]

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

Beta-1,3-galactosyltransferase 6

increases expression

ISO

Curcumin results in increased expression of B3GALT6 mRNA

NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:171,864,094...171,874,789

G

beta-secretase 1

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA

PMID:18583042 PMID:31521693

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2-associated agonist of cell death

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]

PMID:15569404 PMID:19235267 PMID:27430728

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

multiple interactions
decreases expression
increases expression
increases response to substance

ISO

TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in decreased expression of BAK1 mRNA
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression
decreases expression
increases expression
affects localization
increases response to substance

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin affects the expression of BAX protein
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein]

PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

increases expression
decreases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of BBC3 mRNA
Curcumin results in decreased expression of BBC3 mRNA
Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]

PMID:17332930 PMID:22714040 PMID:34047412

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL10, immune signaling adaptor

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA]

NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:237,501,134...237,511,829

G

BCL2, apoptosis regulator

multiple interactions
increases expression
decreases expression

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]

PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
Curcumin results in decreased expression of BCL2A1 mRNA

PMID:16219905 PMID:17596214

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

multiple interactions
decreases expression
increases expression

ISO
EXP

[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA

PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 More...

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

Bcl2-like 11

increases expression
multiple interactions

ISO

Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein

PMID:17332930 PMID:27430728

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

Bcl2-like 2

increases expression
multiple interactions

ISO

Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein

PMID:16101141 PMID:27430728

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

BCL3, transcription coactivator

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]

PMID:18200517 PMID:23452621

NCBI chr 1:88,599,321...88,613,555
Ensembl chr 1:88,599,321...88,614,368

G

BCL6 co-repressor

increases expression

ISO

Curcumin results in increased expression of BCOR mRNA

NCBI chr X:13,282,431...13,402,254
Ensembl chr X:13,360,376...13,402,254

G

brain-derived neurotrophic factor

multiple interactions
increases expression
affects expression

EXP
ISO

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]

PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 More...

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

beclin 1

increases expression
multiple interactions
decreases expression

ISO
EXP

Curcumin results in increased expression of BECN1 protein
MIR206 affects the reaction [Curcumin results in increased expression of BECN1 protein]
Curcumin results in decreased expression of BECN1 protein

PMID:34634291 PMID:36640941 PMID:38764151

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

biglycan

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA]

NCBI chr X:156,348,633...156,360,797
Ensembl chr X:156,348,615...156,360,799

G

BH3 interacting domain death agonist

multiple interactions

ISO

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein]

PMID:20605902 PMID:27430728

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

baculoviral IAP repeat-containing 2

decreases expression
multiple interactions

ISO

Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]

PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 More...

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

baculoviral IAP repeat-containing 3

multiple interactions
increases expression
decreases expression

ISO

[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein

PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 More...

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein
Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein]

PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 More...

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

baculoviral IAP repeat-containing 7

increases expression
multiple interactions

ISO

Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein

PMID:15911101 PMID:27430728

NCBI chr 3:188,425,392...188,430,174
Ensembl chr 3:188,425,392...188,430,174

G

bone morphogenetic protein 2

decreases expression

ISO

Curcumin results in decreased expression of BMP2 mRNA

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

BRCA1, DNA repair associated

multiple interactions

ISO

Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein]

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

basigin

decreases response to substance

ISO

BSG protein results in decreased susceptibility to Curcumin

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

complement C1q A chain

decreases expression

ISO

Curcumin results in decreased expression of C1QA mRNA

NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732

G

complement C1q B chain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA]

NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:154,402,279...154,407,840

G

complement C3

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA]

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

complement C4B

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA]

NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289

G

carbonic anhydrase 9

decreases expression

EXP

Curcumin results in decreased expression of CAR9 mRNA

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

ISO
EXP

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]

PMID:22911773 PMID:29723552

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

capping actin protein, gelsolin like

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA]

NCBI chr 4:106,152,912...106,170,010
Ensembl chr 4:106,152,890...106,170,672

G

caspase 1

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of CASP1 mRNA
Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP1 mRNA]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]

PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475 PMID:38301994 More...

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 12

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:21793155 PMID:25541178

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 2

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of CASP2 mRNA
Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP2 mRNA]

PMID:16101141 PMID:38369055

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein

PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 4

increases expression

ISO

Curcumin results in increased expression of CASP4 mRNA

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727

G

caspase 7

multiple interactions
increases expression
decreases expression

ISO
EXP

[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP7 mRNA]
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA

PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 PMID:38369055

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases activity
multiple interactions
increases cleavage
decreases expression

ISO
EXP

Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP8 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]

PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 More...

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

decreases expression
multiple interactions
increases activity
increases expression
increases cleavage

ISO
EXP

Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]

PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 More...

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases expression
multiple interactions
increases activity

ISO
EXP

Curcumin results in increased expression of CAT protein
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with alpha-Tocopherol] inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Tartrazine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]

PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

carbonyl reductase 1

multiple interactions

ISO

[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein]

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cell division cycle and apoptosis regulator 1

increases expression

ISO

Curcumin results in increased expression of CCAR1 protein

NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227

G

coiled-coil domain containing 116

increases expression

ISO

Curcumin results in increased expression of CCDC116 mRNA

NCBI chr11:97,346,927...97,354,827
Ensembl chr11:97,346,675...97,354,824

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression
increases expression

ISO
EXP

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Cuprizone results in increased expression of CCL2]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA

PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cellular communication network factor 2

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]

PMID:17965732 PMID:19764552

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976

G

cyclin A2

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701

G

cyclin B1

decreases expression

ISO

Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein

PMID:17148446 PMID:18719366 PMID:19401701

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
increases expression
decreases expression
increases degradation

ISO
EXP

[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein

PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin D3

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:20,891,704...20,987,033

G

cyclin E1

decreases expression
multiple interactions
increases degradation

ISO
EXP

Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]

PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cell cycle progression 1

increases expression

ISO

Curcumin results in increased expression of CCPG1 mRNA

NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:82,600,536...82,660,246

G

C-C motif chemokine receptor 2

decreases expression

ISO

Curcumin results in decreased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

CD14 molecule

multiple interactions

ISO

Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD36 molecule

decreases expression
increases expression
multiple interactions

ISO

Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein

PMID:16713233 PMID:23386263 PMID:23603106

NCBI chr 4:18,209,088...18,302,142

G

Cd4 molecule

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD4 protein]

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461

G

CD40 molecule

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of CD40 mRNA
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein

PMID:16101141 PMID:27430728 PMID:35549587

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:174,209,719...174,224,847

G

CD40 ligand

multiple interactions

ISO

[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:140,164,302...140,176,475

G

CD44 molecule

increases expression

ISO

Curcumin results in increased expression of CD44 mRNA

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424

G

Cd47 molecule

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA]

NCBI chr11:64,374,816...64,438,763
Ensembl chr11:64,377,926...64,438,272

G

CD55 molecule (Cromer blood group)

decreases expression

ISO

Curcumin results in decreased expression of CD55 mRNA

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

CD8 subunit alpha

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD8A protein]

NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:104,900,833...104,928,358

G

cell division cycle 14B

increases expression

ISO

Curcumin results in increased expression of CDC14B mRNA

NCBI chr17:850,272...938,972
Ensembl chr17:850,390...971,164

G

cell division cycle 20

decreases expression

ISO

Curcumin results in decreased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cell division cycle 25C

increases phosphorylation

ISO

Curcumin results in increased phosphorylation of CDC25C protein

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cadherin 1

increases expression
multiple interactions

ISO

Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
[Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein]

PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 More...

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cadherin 11

decreases expression

ISO

Curcumin results in decreased expression of CDH11 protein

NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,154,840...2,312,140

G

cadherin 17

decreases expression

ISO

Curcumin results in decreased expression of CDH17 mRNA

NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226

G

cadherin 2

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]

PMID:26191140 PMID:34233590 PMID:35549587

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288

G

cyclin-dependent kinase 1

decreases expression

EXP
ISO

Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein

PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin dependent kinase 2

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 mRNA]; Curcumin inhibits the reaction [Atrazine results in decreased expression of CDK2 protein]
Curcumin results in decreased expression of CDK2 protein
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein

PMID:19501152 PMID:23222814 PMID:26409325 PMID:38301994

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

decreases expression

ISO

Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein

PMID:18156803 PMID:24211270 PMID:26409325

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 5

decreases expression

ISO

Curcumin analog results in decreased expression of CDK5 mRNA

NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777

G

cyclin-dependent kinase 6

decreases expression

ISO

Curcumin results in decreased expression of CDK6 protein

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase 7

decreases expression

ISO

Curcumin analog results in decreased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase 9

decreases expression

ISO

Curcumin analog results in decreased expression of CDK9 mRNA

NCBI chr 3:36,394,168...36,399,016
Ensembl chr 3:36,394,169...36,399,528

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]

PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions
decreases expression

ISO
EXP

Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein

PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 More...

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 2A

decreases expression
increases expression

ISO

Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein

PMID:17148446 PMID:18156803

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

cyclin dependent kinase inhibitor 2D

decreases expression

EXP

Curcumin results in decreased expression of CDKN2D mRNA

NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:28,108,044...28,110,809

G

caudal type homeo box 2

increases expression

EXP
ISO

Curcumin results in increased expression of CDX2 mRNA

PMID:18299980 PMID:27237783

NCBI chr12:12,762,769...12,769,246
Ensembl chr12:12,762,904...12,769,246

G

CCAAT/enhancer binding protein alpha

multiple interactions

ISO

Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA]

PMID:19297423 PMID:28595985

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

CCAAT/enhancer binding protein beta

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA]

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

carboxylesterase 1D

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA]

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

carboxylesterase 3a

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA]

NCBI chr19:49,902,312...49,910,484

G

CASP8 and FADD-like apoptosis regulator

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein

PMID:16173963 PMID:16219905 PMID:23452621

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434

G

CF transmembrane conductance regulator

multiple interactions
increases activity
affects localization

ISO

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form

PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

choline O-acetyltransferase

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

checkpoint kinase 1

decreases response to substance
multiple interactions
increases activity
increases phosphorylation

ISO

CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein

PMID:18602917 PMID:19401701 PMID:27996348

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions
increases phosphorylation

ISO

[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

cholinergic receptor, muscarinic 2

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA]

NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,981,006...66,126,464

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
decreases activity

ISO

Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein

PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

creatine kinase B

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [Gentamicins results in increased secretion of CKM protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]]

PMID:21378372 PMID:29315967 PMID:38056816

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

chloride channel accessory 4

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA]

NCBI chr 2:236,543,975...236,565,096
Ensembl chr 2:236,544,201...236,563,435

G

chloride voltage-gated channel 6

decreases expression

ISO

Curcumin results in decreased expression of CLCN6 mRNA

NCBI chr 5:163,715,593...163,748,301
Ensembl chr 5:163,717,439...163,748,198

G

claudin 1

multiple interactions

ISO

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529

G

claudin 2

multiple interactions

EXP

Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2]

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377

G

claudin 5

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CLDN5 protein]

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:95,717,176...95,719,322

G

collagen type I alpha 1 chain

multiple interactions
decreases expression

EXP
ISO

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein

PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 More...

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type I alpha 2 chain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995

G

collagen type XXVII alpha 1 chain

increases expression

EXP

Curcumin results in increased expression of COL27A1 mRNA

NCBI chr 5:81,662,822...81,781,502
Ensembl chr 5:81,661,685...81,781,502

G

collagen type II alpha 1 chain

increases expression
multiple interactions

ISO

Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein

PMID:18321735 PMID:19889203

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

collagen type III alpha 1 chain

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

collagen type IV alpha 1 chain

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]

PMID:18200517 PMID:21594647 PMID:28700904

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482

G

collagen type IV alpha 2 chain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA]

NCBI chr16:84,749,672...84,885,520
Ensembl chr16:84,749,672...84,885,520

G

collagen type IV alpha 5 chain

decreases expression

ISO

Curcumin results in decreased expression of COL4A5 mRNA

NCBI chr X:109,907,251...110,111,214
Ensembl chr X:109,907,346...110,111,214

G

collagen type V alpha 1 chain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA]

NCBI chr 3:31,606,475...31,755,097
Ensembl chr 3:31,606,486...31,753,020

G

collagen type V alpha 2 chain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA]

NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150

G

carnitine palmitoyltransferase 1A

increases expression

ISO

Curcumin results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

cAMP responsive element binding protein 1

increases expression
multiple interactions
increases phosphorylation

EXP
ISO

Curcumin results in increased expression of CREB1 mRNA
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein]
Curcumin results in increased phosphorylation of CREB1 protein
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]

PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 More...

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element binding protein 3

increases expression

EXP

Curcumin results in increased expression of CREB3 mRNA

NCBI chr 5:62,613,652...62,619,019
Ensembl chr 5:62,613,638...62,619,500

G

CREB binding protein

multiple interactions

ISO

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

C-reactive protein

multiple interactions

EXP
ISO

Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]

PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

crystallin, alpha B

multiple interactions

ISO
EXP

Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

citrate synthase

affects expression

EXP

Curcumin affects the expression of CS mRNA

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

colony stimulating factor 1

multiple interactions

ISO

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468

G

colony stimulating factor 1 receptor

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA

PMID:15129424 PMID:22714040

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806

G

colony stimulating factor 2 receptor subunit alpha

increases expression

ISO

Curcumin results in increased expression of CSF2RA mRNA

NCBI chr14:113,219...118,808
Ensembl chr14:113,225...118,117

G

colony stimulating factor 2 receptor subunit beta

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA]

NCBI chr 7:111,756,950...111,782,089
Ensembl chr 7:111,757,405...111,784,654

G

catenin beta 1

decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation

ISO
EXP

Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein

PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 More...

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin B

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA

PMID:8534267 PMID:26409325

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA

PMID:8534267 PMID:26409325

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin L

decreases expression

ISO

Curcumin results in decreased expression of CTSL protein

NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113

G

cathepsin S

decreases expression

ISO

Curcumin results in decreased expression of CTSS mRNA

NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440

G

cullin 3

multiple interactions

ISO

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA]

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

C-X-C motif chemokine ligand 1

multiple interactions
decreases expression

ISO

NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

Curcumin inhibits the reaction [Cuprizone results in increased expression of CXCL10]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 12

multiple interactions

ISO

Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 14

decreases expression

ISO

Curcumin results in decreased expression of CXCL14 mRNA

NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172

G

C-X-C motif chemokine ligand 2

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]

PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine ligand 3

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]

PMID:17999991 PMID:27194111

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

C-X-C motif chemokine receptor 1

increases expression

ISO

Curcumin results in increased expression of CXCR1 protein

NCBI chr 9:83,216,040...83,220,225
Ensembl chr 9:83,215,292...83,226,872

G

C-X-C motif chemokine receptor 2

increases expression

ISO

Curcumin results in increased expression of CXCR2 protein

NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:83,183,808...83,188,602

G

C-X-C motif chemokine receptor 4

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]

PMID:17198877 PMID:18660423

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome c, somatic

affects localization
multiple interactions

ISO

Curcumin affects the localization of CYCS protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein

PMID:19235267 PMID:27430728 PMID:33617879

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

chymosin

increases expression

EXP

Curcumin results in increased expression of CYM mRNA

NCBI chr 2:197,516,947...197,527,307
Ensembl chr 2:197,516,950...197,527,837

G

cytochrome P450, family 19, subfamily a, polypeptide 1

affects binding

EXP

Curcumin binds to CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases activity
increases expression
decreases activity
decreases expression

ISO
EXP

Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions

ISO
EXP

Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]

PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA

PMID:17637178 PMID:19018768

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions
increases expression

ISO

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:179,694,647...179,709,083

G

cytochrome P450, family 2, subfamily b, polypeptide 1

affects expression
multiple interactions

EXP

Curcumin affects the expression of CYP2B1 protein
Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine]

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein]

NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

ISO

Curcumin results in decreased expression of CYP2D6 mRNA

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects expression
multiple interactions
increases expression

EXP
ISO

Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA

PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
multiple interactions
increases expression

ISO

Curcumin results in decreased expression of CYP3A4 mRNA
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
Curcumin results in increased expression of CYP3A4 mRNA

PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 More...

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression

EXP

Curcumin results in increased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

cytohesin 4

increases expression

ISO

Curcumin results in increased expression of CYTH4 mRNA

NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:112,032,775...112,057,204

G

death-domain associated protein

increases expression

ISO

Curcumin results in increased expression of DAXX mRNA

NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720

G

drebrin 1

multiple interactions

EXP

Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA]

NCBI chr17:9,155,729...9,170,121
Ensembl chr17:9,155,787...9,170,122

G

decorin

increases expression

ISO

Curcumin results in increased expression of DCN mRNA

NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926

G

doublecortin

multiple interactions
increases expression

EXP
ISO

Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein]
Curcumin results in increased expression of DCX mRNA

PMID:25963729 PMID:32735850

NCBI chr X:112,227,455...112,370,291
Ensembl chr X:112,227,455...112,304,161

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein

PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 More...

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4-like

decreases expression
increases expression

ISO
EXP

Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA

PMID:17999991 PMID:18299980

NCBI chr 2:228,800,831...228,804,478
Ensembl chr 2:228,801,705...228,806,225

G

derlin 1

increases expression

ISO

Curcumin results in increased expression of DERL1 mRNA

NCBI chr 7:91,293,963...91,316,639
Ensembl chr 7:91,258,382...91,316,678

G

desmin

multiple interactions

EXP

Curcumin inhibits the reaction [Gentamicins results in increased expression of DES mRNA]

NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347

G

DNA fragmentation factor subunit beta

increases expression
decreases expression

ISO

Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein

PMID:21397623 PMID:22714040

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

24-dehydrocholesterol reductase

decreases expression
affects expression

EXP
ISO

Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

7-dehydrocholesterol reductase

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

dehydrogenase/reductase 1

decreases expression

ISO

Curcumin results in decreased expression of DHRS1 mRNA

NCBI chr15:33,206,449...33,213,776
Ensembl chr15:33,206,451...33,213,734

G

diablo, IAP-binding mitochondrial protein

multiple interactions
affects localization
increases expression
increases response to substance

ISO

[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin affects the localization of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin

PMID:17277231 PMID:23555722 PMID:27430728

NCBI chr12:38,716,668...38,731,285
Ensembl chr12:38,716,668...38,731,265

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression
multiple interactions

EXP

Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

discs large MAGUK scaffold protein 4

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein]

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

ISO

Curcumin results in increased expression of DNAJB9 mRNA

NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:66,997,842...67,009,344

G

dynamin 1-like

multiple interactions

EXP

Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

DNA methyltransferase 1

increases activity
affects expression
multiple interactions
decreases expression

ISO

Curcumin results in increased activity of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog results in decreased expression of DNMT1 protein

PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

DNA methyltransferase 3 alpha

decreases expression

ISO

Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970

G

DNA methyltransferase 3 beta

decreases expression

ISO

Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein

PMID:23593078 PMID:26991801 PMID:29228771

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313

G

DNA-damage regulated autophagy modulator 1

increases expression

ISO

Curcumin results in increased expression of DRAM1 mRNA

NCBI chr 7:24,630,233...24,665,270
Ensembl chr 7:24,630,238...24,664,354

G

dopamine receptor D2

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dual specificity phosphatase 1

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]

PMID:15713895 PMID:20885979

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

dual specificity phosphatase 10

increases expression

ISO

Curcumin results in increased expression of DUSP10 mRNA

PMID:15713895 PMID:17151092

NCBI chr13:98,145,317...98,183,304
Ensembl chr13:98,145,893...98,183,304

G

dual specificity phosphatase 5

increases expression

ISO

Curcumin results in increased expression of DUSP5 mRNA

NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:262,543,738...262,562,417

G

dishevelled segment polarity protein 1

multiple interactions
decreases expression
increases expression

EXP
ISO

Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]
Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein

PMID:19573523 PMID:25963729

NCBI chr 5:171,738,911...171,750,967
Ensembl chr 5:171,739,133...171,750,966

G

dynein light chain LC8-type 1

increases expression

ISO

Curcumin results in increased expression of DYNLL1 mRNA

NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861

G

dual specificity tyrosine phosphorylation regulated kinase 2

decreases activity
multiple interactions

ISO

Curcumin results in decreased activity of DYRK2 protein
[Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein

NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:56,235,276...56,265,942

G

E2F transcription factor 1

decreases expression

EXP

Curcumin results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 5

decreases expression

ISO

Curcumin results in decreased expression of E2F5 mRNA

NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:88,718,567...88,734,143

G

enoyl-CoA hydratase 1

increases expression

EXP

Curcumin results in increased expression of ECH1 mRNA

NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440

G

EDAR associated via death domain

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]

NCBI chr17:92,850,791...92,894,808
Ensembl chr17:92,831,613...92,894,361

G

ER degradation enhancing alpha-mannosidase like protein 1

increases expression

ISO

Curcumin results in increased expression of EDEM1 mRNA

NCBI chr 4:143,350,989...143,385,693
Ensembl chr 4:143,353,624...143,388,060

G

EGF like repeats and discoidin domains 3

decreases expression

ISO

Curcumin results in decreased expression of EDIL3 mRNA

NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379

G

epidermal growth factor

multiple interactions
decreases activity

ISO
EXP

Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]
Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
decreases expression

ISO
EXP

Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; Curcumin inhibits the reaction [Diethylnitrosamine results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein

PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 More...

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions
increases expression
decreases expression

ISO
EXP

EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA

PMID:17198877 PMID:17999991 PMID:18316600

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

eukaryotic translation initiation factor 1

decreases expression

ISO

Curcumin results in decreased expression of EIF1 mRNA

NCBI chr10:85,747,064...85,749,447
Ensembl chr 5:25,895,968...25,896,654
Ensembl chr10:25,895,968...25,896,654

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

ISO

Curcumin inhibits the reaction [bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of EIF2AK3 protein]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases expression
decreases phosphorylation

ISO

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein

PMID:18790744 PMID:23222814 PMID:34634291

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874

G

eukaryotic translation initiation factor 4 gamma 1

decreases phosphorylation

ISO

Curcumin results in decreased phosphorylation of EIF4G1 protein

NCBI chr11:93,726,322...93,746,387
Ensembl chr11:93,726,322...93,746,367

G

E74 like ETS transcription factor 2

decreases expression

ISO

Curcumin results in decreased expression of ELF2 mRNA

NCBI chr 2:137,445,787...137,536,512
Ensembl chr 2:137,445,788...137,470,355

G

ETS transcription factor ELK1

multiple interactions
increases phosphorylation

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]

PMID:18316600 PMID:23452621

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:3,693,293...3,709,249

G

embigin

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA]

NCBI chr 2:50,803,468...50,858,001
Ensembl chr 2:50,801,973...50,862,920

G

enolase 1

decreases expression

ISO

Curcumin results in decreased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

EXP

Curcumin results in increased expression of ENTPD5 mRNA

NCBI chr 6:109,750,210...109,786,376
Ensembl chr 6:109,753,204...109,786,495

G

E1A binding protein p300

multiple interactions
decreases activity
decreases expression
affects localization

ISO
EXP

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein

PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

endothelial PAS domain protein 1

multiple interactions

ISO

Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729

G

epithelial cell adhesion molecule

multiple interactions
decreases expression

ISO

WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]
Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein

NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702

G

erythropoietin

decreases expression

ISO

Curcumin results in decreased expression of EPO mRNA

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725

G

eosinophil peroxidase

multiple interactions

ISO

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]

NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
increases response to substance
increases degradation
decreases expression

ISO

[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein

PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 More...

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 3

multiple interactions
decreases expression

ISO

Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA

PMID:15713895 PMID:17918158 PMID:26409325

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein

PMID:17596214 PMID:21493726 PMID:22228707

NCBI chr 1:88,099,308...88,135,966
Ensembl chr 1:88,118,891...88,139,120

G

ERCC excision repair 4, endonuclease catalytic subunit

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein

NCBI chr10:2,926,085...2,958,176
Ensembl chr10:2,920,455...2,955,539

G

endoplasmic reticulum lectin 1

increases expression

ISO

Curcumin results in increased expression of ERLEC1 mRNA

NCBI chr14:108,856,661...108,894,511
Ensembl chr14:108,856,661...108,894,297

G

endoplasmic reticulum to nucleus signaling 1

decreases expression
increases expression

ISO

Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA

PMID:17999991 PMID:29723631

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol affects the localization of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [Fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein

PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 PMID:38229314

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

ETS proto-oncogene 2, transcription factor

decreases expression

ISO

Curcumin results in decreased expression of ETS2 protein

NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842

G

coagulation factor II, thrombin

multiple interactions

EXP

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246

G

coagulation factor II (thrombin) receptor

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA]

NCBI chr 2:28,604,066...28,620,579
Ensembl chr 2:28,604,066...28,620,579

G

coagulation factor III, tissue factor

multiple interactions

ISO

Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 3

multiple interactions

EXP

Curcumin inhibits the reaction [Gentamicins results in increased expression of FABP3 mRNA]

NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881

G

Fas associated via death domain

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA]

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

fatty acid desaturase 1

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA

NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615

G

fatty acid desaturase 2

decreases expression
affects expression

EXP
ISO

Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA

NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:216,133,676...216,172,066

G

family with sequence similarity 120 member B

decreases expression

ISO

Curcumin results in decreased expression of FAM120B mRNA

NCBI chr 1:64,993,104...65,058,160
Ensembl chr 1:65,012,060...65,058,160

G

family with sequence similarity 8, member A1

increases expression

ISO

Curcumin results in increased expression of FAM8A1 mRNA

NCBI chr17:18,232,834...18,241,736
Ensembl chr17:18,232,834...18,241,703

G

FA complementation group D2

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA

NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035

G

FA complementation group I

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA

NCBI chr 1:142,736,636...142,792,999
Ensembl chr 1:142,736,653...142,792,999

G

Fas cell surface death receptor

multiple interactions

ISO
EXP

[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein
Curcumin inhibits the reaction [fenpropathrin results in increased expression of FAS mRNA]

PMID:27430728 PMID:38369055

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
decreases expression

ISO
EXP

[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin inhibits the reaction [fenpropathrin results in increased expression of FASL mRNA]
Curcumin results in decreased expression of FASLG mRNA

PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 More...

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fatty acid synthase

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibulin 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA]

NCBI chr 4:125,261,464...125,321,030
Ensembl chr 4:125,261,607...125,321,029

G

F-box protein 6

increases expression

ISO

Curcumin results in increased expression of FBXO6 mRNA

NCBI chr 5:163,859,909...163,865,693
Ensembl chr 5:163,859,916...163,865,574

G

Fc gamma receptor 3A

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA]

NCBI chr13:85,782,636...85,792,656
Ensembl chr13:85,782,490...85,792,651

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

EXP

Curcumin results in decreased expression of FDFT1 mRNA

NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168

G

farnesyl diphosphate synthase

increases expression
decreases expression
affects expression

ISO
EXP

Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA

PMID:16713233 PMID:27208389

NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136

G

fibroblast growth factor 2

decreases expression
increases expression

ISO

Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

fibroblast growth factor 5

decreases expression

ISO

Curcumin results in decreased expression of FGF5 mRNA

NCBI chr14:11,627,906...11,650,243
Ensembl chr14:11,627,906...11,650,243

G

fibroblast growth factor receptor 2

decreases expression

ISO

Curcumin results in decreased expression of FGFR2 mRNA

NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:194,175,705...194,280,914

G

filamin A interacting protein 1-like

increases expression

ISO

Curcumin results in increased expression of FILIP1L mRNA

NCBI chr11:56,403,467...56,646,422
Ensembl chr11:56,410,582...56,646,402

G

fission, mitochondrial 1

multiple interactions

EXP

Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

Fms related receptor tyrosine kinase 1

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]
Curcumin results in decreased expression of FLT1 protein

PMID:18593936 PMID:23845850

NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750

G

fibronectin 1

multiple interactions
decreases expression

ISO
EXP

Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]

PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

farnesyltransferase, CAAX box, subunit beta

increases expression

ISO

Curcumin results in increased expression of FNTB mRNA

NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:101,269,671...101,352,716

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions
increases expression

ISO
EXP

Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]

PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions
increases ubiquitination

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391

G

FOS like 2, AP-1 transcription factor subunit

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]

PMID:17148446 PMID:17999991

NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:30,021,916...30,039,406

G

forkhead box A1

multiple interactions

ISO

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]]

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box A2

decreases expression

ISO

Curcumin results in decreased expression of FOXA2 mRNA

NCBI chr 3:155,923,305...155,927,508
Ensembl chr 3:155,923,307...155,928,757

G

forkhead box F2

decreases expression

ISO

Curcumin results in decreased expression of FOXF2 mRNA

NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,846,603...33,051,259

G

forkhead box O1

increases expression
decreases phosphorylation

ISO

Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein

PMID:18403477 PMID:18790744

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

formyl peptide receptor 3

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA]

NCBI chr 1:67,557,464...67,566,509
Ensembl chr 1:67,518,199...67,566,519

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

follistatin-like 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]

NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126

G

ferritin heavy chain 1

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FTH1 protein]
Curcumin inhibits the reaction [Firemaster BP-6 results in decreased expression of FTH1 protein]

PMID:34787501 PMID:39934342

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

ferritin light chain 1

decreases expression

ISO

Curcumin results in decreased expression of FTL1 mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

Fus RNA binding protein

increases expression
decreases expression

ISO

Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA

PMID:17198877 PMID:17999991

NCBI chr 1:192,007,011...192,020,887
Ensembl chr 1:192,007,006...192,020,884

G

frizzled class receptor 1

decreases expression

ISO

Curcumin results in decreased expression of FZD1 mRNA

NCBI chr 4:30,265,074...30,269,472
Ensembl chr 4:30,247,228...30,833,176

G

glucose-6-phosphatase catalytic subunit 1

affects expression

ISO

Curcumin affects the expression of G6PC1 mRNA

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

increases expression
multiple interactions

EXP
ISO

Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein]

PMID:18299980 PMID:36924976

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases expression

EXP

Curcumin results in decreased expression of GABRA1 mRNA

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442

G

glutamate decarboxylase 1

multiple interactions

EXP

Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]

NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759

G

growth arrest and DNA-damage-inducible, alpha

increases expression

EXP
ISO

Curcumin results in increased expression of GADD45A mRNA

PMID:16101141 PMID:18299980 PMID:18719366

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

growth arrest specific 6

increases expression

ISO

Curcumin results in increased expression of GAS6 mRNA

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

GATA binding protein 2

multiple interactions

ISO

Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]

NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:122,211,829...122,225,055

G

GATA binding protein 3

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GATA3 mRNA]

NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670

G

GATA binding protein 4

decreases expression

ISO

Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein

NCBI chr15:41,635,572...41,707,252
Ensembl chr15:41,635,572...41,681,609

G

glutamate-cysteine ligase, catalytic subunit

increases activity
multiple interactions
increases expression

ISO
EXP

Curcumin results in increased activity of GCLC protein
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein]

PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 More...

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

EXP
ISO

Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]

PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 More...

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

guanine deaminase

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA]

NCBI chr 1:228,333,401...228,408,901
Ensembl chr 1:228,333,364...228,409,348

G

glial fibrillary acidic protein

multiple interactions
decreases expression

ISO
EXP

Curcumin inhibits the reaction [Cuprizone results in increased expression of GFAP protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]
Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]

PMID:19555370 PMID:25963729 PMID:39586379

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gamma-glutamyltransferase 1

increases expression
multiple interactions

EXP

Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]

PMID:18299980 PMID:24704557

NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,141...13,088,050

G

glycoprotein alpha-galactosyltransferase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA]

NCBI chr 3:39,130,466...39,208,652
Ensembl chr 3:39,130,467...39,206,870

G

gap junction protein, alpha 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

GLI family zinc finger 1

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]

PMID:20395211 PMID:31612257

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:65,042,237...65,054,540

G

GLI family zinc finger 2

multiple interactions

EXP

Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]]

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

glyoxalase 1

decreases activity

ISO

Curcumin results in decreased activity of GLO1 protein

NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein]

PMID:16956363 PMID:36037877

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic-oxaloacetic transaminase 1-like 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA]

NCBI chr16:71,563,562...71,576,446
Ensembl chr16:71,563,534...71,570,468

G

glycerol-3-phosphate acyltransferase, mitochondrial

decreases expression
affects expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]

PMID:19297423 PMID:27208389

NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911

G

G protein-coupled estrogen receptor 1

decreases expression

ISO

Curcumin results in decreased expression of GPER1 mRNA

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

gephyrin

affects expression

EXP

Curcumin affects the expression of GPHN mRNA

NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:102,687,423...103,216,674

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Tartrazine results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin inhibits the reaction [Firemaster BP-6 results in increased expression of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]

PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 More...

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

decreases expression
multiple interactions

EXP
ISO

Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein]
Curcumin inhibits the reaction [Atrazine results in decreased activity of GPX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]

PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976 More...

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 4

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of GPX4 protein]
Curcumin inhibits the reaction [Firemaster BP-6 results in decreased expression of GPX4 protein]

PMID:34787501 PMID:39934342

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

growth factor receptor bound protein 10

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]

NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387

G

growth factor receptor bound protein 2

decreases expression

ISO

Curcumin analog results in decreased expression of GRB2 mRNA

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

gremlin 1, DAN family BMP antagonist

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA]

NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089

G

glutamate ionotropic receptor AMPA type subunit 4

multiple interactions

EXP

Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]

NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:9,847,052...10,319,881

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]

PMID:23267840 PMID:29723552

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

EXP

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein]

PMID:25496357 PMID:29723552

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

EXP

Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein]

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570

G

glutamate metabotropic receptor 2

decreases expression

ISO

Curcumin results in decreased expression of GRM2 protein

NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857

G

gasdermin D

multiple interactions

ISO
EXP

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of GSDMD protein]
Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in decreased expression of GSDMD mRNA]

PMID:34998855 PMID:35063475 PMID:38301994 PMID:38369055

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

glycogen synthase kinase 3 beta

decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression

ISO
EXP

Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein

PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 More...

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

gelsolin

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA]

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:38,982,671...39,035,850

G

glutathione-disulfide reductase

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of GSR mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein]
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]

PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 More...

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione synthetase

increases expression
multiple interactions

ISO

Curcumin results in increased expression of GSS mRNA
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA]

PMID:19183254 PMID:35063475

NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:164,508,005...164,538,306

G

glutathione S-transferase alpha 4

increases activity

ISO

Curcumin results in increased activity of GSTA4 protein

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:87,930,566...87,964,488

G

glutathione S-transferase alpha 5

increases expression

EXP

Curcumin results in increased expression of GSTA5 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase kappa 1

multiple interactions

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA]

NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927

G

glutathione S-transferase omega 1

increases expression
multiple interactions

ISO

Curcumin results in increased expression of GSTO1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]

NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167

G

glutathione S-transferase pi 1

multiple interactions
affects expression
increases expression
decreases expression

ISO
EXP

[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein

PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 More...

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glucuronidase, beta

multiple interactions

EXP

Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

granzyme A

multiple interactions

EXP

Curcumin inhibits the reaction [fenpropathrin results in increased expression of GZMA mRNA]

NCBI chr 2:46,473,763...46,485,696
Ensembl chr 2:46,473,763...46,485,696

G

H19 imprinted maternally expressed transcript

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of H19 mRNA
curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells]
curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment]

CTD
RGD

PMID:18348204 PMID:34487706 PMID:34487706

RGD:156430326, RGD:156430326

NCBI chr 1:207,160,175...207,162,851

G

H1.10 linker histone

decreases expression

ISO

Curcumin results in decreased expression of H1-10 mRNA

NCBI chr 4:121,997,834...121,998,897
Ensembl chr 4:121,997,831...121,998,966

G

H2A.X variant histone

multiple interactions
increases phosphorylation

ISO

[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein

PMID:19401701 PMID:21134073

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

H2B clustered histone 14

increases expression

ISO

Curcumin results in increased expression of H2BC5 mRNA

NCBI chr17:47,488,627...47,489,008

G

H2B clustered histone 27

increases expression

ISO

Curcumin results in increased expression of H2BC26 mRNA

NCBI chr10:44,232,318...44,233,065
Ensembl chr10:44,232,318...44,233,065

G

H3.4 histone, cluster member

increases acetylation
increases phosphorylation

EXP

Curcumin results in increased acetylation of H3F4 protein
Curcumin results in increased phosphorylation of H3F4 protein

NCBI chr10:44,240,282...44,240,842

G

hepcidin antimicrobial peptide

decreases expression

ISO

Curcumin results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:95,298,307...95,300,297

G

heart and neural crest derivatives expressed 1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA

NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,507,122...42,509,684

G

heart and neural crest derivatives expressed 2

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA

NCBI chr16:37,928,145...37,931,488
Ensembl chr16:37,928,145...37,931,488

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of HAVCR1 mRNA]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein]

PMID:25119790 PMID:29421648 PMID:30431687 PMID:38056816

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

HBS1-like translational GTPase

decreases expression

ISO

Curcumin results in decreased expression of HBS1L mRNA

NCBI chr 1:17,912,139...17,989,651
Ensembl chr 1:17,912,070...17,989,646

G

HCK proto-oncogene, Src family tyrosine kinase

decreases activity
multiple interactions

ISO

Curcumin analog results in decreased activity of HCK protein
[Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein

NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935

G

histone deacetylase 1

multiple interactions
decreases expression
affects localization

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 protein

PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

histone deacetylase 11

decreases expression

ISO

Curcumin analog results in decreased expression of HDAC11 mRNA

NCBI chr 4:125,203,044...125,224,584
Ensembl chr 4:125,202,299...125,224,582

G

histone deacetylase 2

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA

PMID:18421014 PMID:26409325

NCBI chr20:42,101,815...42,126,486
Ensembl chr20:42,102,861...42,126,311

G

histone deacetylase 3

decreases expression

ISO

Curcumin results in decreased expression of HDAC3 protein

NCBI chr18:30,021,847...30,041,061
Ensembl chr18:30,021,941...30,041,025

G

histone deacetylase 4

decreases expression

ISO

Curcumin analog results in decreased expression of HDAC4 mRNA
Curcumin analog results in decreased expression of HDAC4 protein

PMID:26409325 PMID:26991801 PMID:29228771

NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:99,955,116...100,197,637

G

histone deacetylase 6

decreases expression

ISO

Curcumin analog results in decreased expression of HDAC6 mRNA

NCBI chr X:17,222,538...17,244,373
Ensembl chr X:17,222,856...17,244,370

G

histone deacetylase 7

decreases expression

ISO

Curcumin analog results in decreased expression of HDAC7 protein

NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:130,803,013...130,841,017

G

histone deacetylase 8

decreases expression

ISO

Curcumin analog results in decreased expression of HDAC8 mRNA

NCBI chr X:71,425,240...71,632,865
Ensembl chr X:71,394,928...71,632,865

G

heme binding protein 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA]

NCBI chr 1:15,014,729...15,021,523
Ensembl chr 1:15,014,729...15,021,523

G

hes family bHLH transcription factor 1

multiple interactions

ISO

[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

hepatocyte growth factor

increases expression
decreases expression

ISO

Curcumin results in increased expression of HGF protein
Curcumin results in decreased expression of HGF protein

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression
decreases activity

ISO
EXP

[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein]
Curcumin results in decreased expression of HIF1A mRNA
Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA
Curcumin results in decreased activity of HIF1A protein

PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 More...

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histone cluster 1 H2B family member Q

increases expression

EXP

Curcumin results in increased expression of HIST1H2BQ mRNA

NCBI chr17:41,859,955...41,869,889
Ensembl chr17:41,857,231...41,870,107
Ensembl chr17:41,857,231...41,870,107

G

hexokinase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein]

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814

G

hexokinase 2

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of HK2 protein
4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein]

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

high mobility group box 1

multiple interactions

EXP

bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]

PMID:22683883 PMID:29480285

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions
decreases expression
affects expression

ISO
EXP

Curcumin results in increased expression of HMGCR mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein]
Curcumin results in decreased expression of HMGCR mRNA
Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein

PMID:16713233 PMID:27208389 PMID:37701206

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

EXP

Curcumin results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression
decreases response to substance
increases activity

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]
Curcumin results in decreased expression of HMOX1 mRNA
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with Curcumin] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; linderalactone promotes the reaction [[Lipopolysaccharides co-treated with Curcumin] results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein
HMOX1 protein results in decreased susceptibility to Curcumin
[Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein]

PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heterogeneous nuclear ribonucleoprotein A1

decreases expression

ISO

Curcumin results in decreased expression of HNRNPA1 mRNA

NCBI chr 7:136,253,633...136,260,085
Ensembl chr 7:136,253,278...136,260,085

G

heterogeneous nuclear ribonucleoprotein D

decreases expression

ISO

Curcumin results in decreased expression of HNRNPD mRNA

NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,919,739...9,938,066

G

HOP homeobox

increases expression

EXP

Curcumin results in increased expression of HOPX mRNA

NCBI chr14:31,410,235...31,437,189
Ensembl chr14:31,410,221...31,437,188

G

homeo box B5

increases expression

ISO

Curcumin results in increased expression of HOXB5 mRNA

NCBI chr10:81,765,911...81,768,119

G

hypoxanthine phosphoribosyltransferase 1

increases expression

ISO

Curcumin results in increased expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:137,655,680...137,687,712

G

heat shock transcription factor 1

multiple interactions

EXP
ISO

[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein
Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein]

PMID:9764755 PMID:11322385

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

heat shock protein 90 alpha family class A member 1

decreases expression

ISO

Curcumin analog results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein 90 alpha family class B member 1

multiple interactions

EXP

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA]

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein 90 beta family member 1

decreases expression

ISO

Curcumin analog results in decreased expression of HSP90B1 mRNA

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family A (Hsp70) member 1A

increases expression
multiple interactions
decreases expression

ISO
EXP

Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA]
Curcumin results in decreased expression of HSPA1A protein

PMID:23555722 PMID:26361869

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 4

increases expression

ISO

Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
decreases expression

ISO

Curcumin results in increased expression of HSPA5 mRNA
Curcumin inhibits the reaction [bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate results in increased expression of HSPA5 protein]
Curcumin results in decreased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]

PMID:18200517 PMID:27996348 PMID:29723631 PMID:34784780 PMID:36640941

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

heat shock protein family B (small) member 1

multiple interactions

EXP

Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein]

PMID:18204486 PMID:20125031

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family B (small) member 7

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA]

NCBI chr 5:159,010,759...159,014,245
Ensembl chr 5:159,010,629...159,014,243

G

heat shock protein family D (Hsp60) member 1

multiple interactions

EXP
ISO

Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein

PMID:26361869 PMID:27430728

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

5-hydroxytryptamine receptor 1A

affects expression

EXP

Curcumin affects the expression of HTR1A mRNA

NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760

G

intercellular adhesion molecule 1

multiple interactions
decreases expression
affects expression

ISO
EXP

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]
[chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA]
Curcumin results in decreased expression of ICAM1 protein
Curcumin affects the expression of ICAM1 mRNA

PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 More...

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 1

decreases expression

ISO

Curcumin results in decreased expression of ID1 mRNA

NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685

G

inhibitor of DNA binding 2

decreases expression

ISO

Curcumin results in decreased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of DNA binding 3

decreases expression

ISO

Curcumin results in decreased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

indoleamine 2,3-dioxygenase 1

decreases expression

ISO

Curcumin results in decreased expression of IDO1 mRNA

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

interferon, alpha 1

multiple interactions

ISO

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]

PMID:17979888 PMID:23452621

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon alpha and beta receptor subunit 1

multiple interactions

ISO

Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]

NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205

G

interferon alpha and beta receptor subunit 2

multiple interactions

ISO

Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]

NCBI chr11:44,099,574...44,131,941
Ensembl chr11:44,099,753...44,131,937

G

interferon beta 1

multiple interactions

ISO

Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487

G

interferon gamma

multiple interactions
increases secretion

ISO
EXP

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA]
[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
Curcumin results in increased secretion of IFNG protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]

PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon kappa

decreases expression

ISO

Curcumin results in decreased expression of IFNK mRNA

NCBI chr 5:54,528,304...54,530,511
Ensembl chr 5:54,528,304...54,530,511

G

insulin-like growth factor 1

decreases activity
multiple interactions
decreases expression
decreases secretion

ISO

Curcumin results in decreased activity of IGF1 protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA]
Curcumin results in decreased secretion of IGF1 protein

PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein]
Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA

PMID:17499312 PMID:17918158 PMID:26409325

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

insulin-like growth factor 2

decreases expression
multiple interactions

ISO

Curcumin analog results in decreased expression of IGF2 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein

PMID:26409325 PMID:27430728

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:207,243,873...207,260,667

G

insulin-like growth factor binding protein 1

multiple interactions

ISO

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein

NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344

G

insulin-like growth factor binding protein 2

multiple interactions

ISO

[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein

NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171

G

insulin-like growth factor binding protein 3

decreases expression
increases secretion
increases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of IGFBP3 mRNA
Curcumin results in increased secretion of IGFBP3 protein
Curcumin results in increased expression of IGFBP3 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein

PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

insulin-like growth factor binding protein 4

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein

PMID:18200517 PMID:27430728

NCBI chr10:84,491,471...84,503,487
Ensembl chr10:84,485,775...84,503,473

G

insulin-like growth factor binding protein 5

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA]
[arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein

PMID:18200517 PMID:27430728

NCBI chr 9:81,901,605...81,914,187
Ensembl chr 9:81,897,616...81,914,390

G

insulin-like growth factor binding protein 7

increases expression

ISO

Curcumin results in increased expression of IGFBP7 mRNA

NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions
decreases activity

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
Curcumin results in decreased activity of IKBKB protein

PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 More...

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA]

NCBI chr X:157,358,279...157,397,563
Ensembl chr X:157,367,639...157,392,757

G

interleukin 10

multiple interactions
decreases expression

ISO
EXP

Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]
Curcumin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein]; Curcumin inhibits the reaction [Cuprizone results in decreased expression of IL10]
Curcumin results in decreased expression of IL10 protein
CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in decreased expression of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]

PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 More...

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 12A

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA]

PMID:16867261 PMID:23452621

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 17A

multiple interactions

ISO

Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IL17A mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of IL17A protein]

PMID:34998855 PMID:35716765 PMID:36178099 PMID:39750044

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 18

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL18 protein]
Curcumin results in decreased expression of IL18 mRNA
Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein

PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475 PMID:38301994

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 alpha

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]
Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein]

PMID:18719352 PMID:19782127

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

affects expression
multiple interactions
decreases expression

ISO
EXP

Curcumin affects the expression of IL1B mRNA
Curcumin inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of IL1B mRNA]]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Freund's Adjuvant results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]]

PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor-like 1

multiple interactions

ISO

Curcumin inhibits the reaction [Cisplatin results in increased expression of IL1RL1 protein]

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891

G

interleukin 2

multiple interactions

ISO

Curcumin results in decreased expression of and results in decreased secretion of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 23 subunit alpha

multiple interactions

ISO

Curcumin inhibits the reaction [Cisplatin results in increased expression of IL23A protein]

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:1,306,320...1,308,434

G

interleukin 2 receptor subunit alpha

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein]

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 4

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein]
Curcumin results in decreased expression of IL4 protein
Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of IL4 mRNA]

PMID:16782535 PMID:16867261 PMID:21397623 PMID:39750044

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

multiple interactions

ISO

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

interleukin 6

multiple interactions
decreases expression
increases expression
affects expression

ISO
EXP

Curcumin inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Cuprizone results in increased expression of IL6]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]
Curcumin results in increased expression of IL6 protein
Curcumin results in increased expression of IL6 mRNA
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Freund's Adjuvant results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]
Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein

PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 6 receptor

multiple interactions

ISO

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein]

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221

G

interleukin 6 cytokine family signal transducer

multiple interactions

ISO

Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein]

NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182

G

insulin 1

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Lamotrigine results in increased expression of INS1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]

PMID:23267840 PMID:25541178 PMID:27208389 PMID:38050455

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin 2

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Fructose results in increased expression of INS protein]
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]

PMID:25268984 PMID:26713546 PMID:28595985

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805

G

insulin induced gene 2

multiple interactions

ISO

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]

NCBI chr13:35,025,160...35,052,937
Ensembl chr13:35,025,164...35,047,658

G

insulin receptor

multiple interactions

ISO

Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form]

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

inositol 1,4,5-triphosphate receptor associated 2

decreases expression

ISO

Curcumin results in decreased expression of IRAG2 mRNA

NCBI chr 4:179,819,526...179,874,408
Ensembl chr 4:179,820,188...179,874,406

G

interleukin-1 receptor-associated kinase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA]

PMID:16678799 PMID:23452621

NCBI chr X:156,919,927...156,929,825
Ensembl chr X:156,920,081...156,929,825

G

interleukin-1 receptor-associated kinase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA]

NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210

G

interferon regulatory factor 3

multiple interactions

ISO

Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

interferon regulatory factor 5

increases expression

ISO

Curcumin analog results in increased expression of IRF5 mRNA

NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552

G

insulin receptor substrate 1

multiple interactions
affects phosphorylation

EXP
ISO

Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein]
Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form]
Curcumin affects the phosphorylation of IRS1 protein

PMID:26713546 PMID:27208389 PMID:29793316

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

insulin receptor substrate 2

affects phosphorylation

ISO

Curcumin affects the phosphorylation of IRS2 protein

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

integrin subunit alpha 2b

multiple interactions

EXP

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]

NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833

G

integrin subunit alpha M

multiple interactions
increases expression

ISO

Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 1

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]
Curcumin results in increased expression of ITGB1 protein

NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269

G

integrin subunit beta 3

multiple interactions

EXP

Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

integral membrane protein 2A

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA]

NCBI chr X:76,559,183...76,565,144
Ensembl chr X:76,559,181...76,565,437

G

involucrin

multiple interactions

ISO

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]

NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:180,842,307...180,846,578

G

Janus kinase 2

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of JAK2 protein
Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of JAK2 protein]
Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein]

PMID:16959222 PMID:34233590 PMID:36352148 PMID:39750044

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Janus kinase 3

decreases activity

ISO

Curcumin results in decreased activity of JAK3 protein

NCBI chr16:18,418,807...18,432,515
Ensembl chr16:18,420,415...18,433,222

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases phosphorylation
multiple interactions
increases expression
decreases activity

ISO
EXP

Curcumin results in decreased phosphorylation of JUN protein
Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein]
Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Cisplatin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein]
Curcumin results in increased expression of JUN mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein]
Curcumin results in decreased activity of JUN protein

PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases ubiquitination

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]
Curcumin results in increased ubiquitination of JUNB protein

NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein]

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

potassium voltage-gated channel subfamily H member 2

decreases activity

ISO

Curcumin results in decreased activity of KCNH2 protein

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

potassium calcium-activated channel subfamily M regulatory beta subunit 2

decreases expression

ISO

Curcumin results in decreased expression of KCNMB2 mRNA

NCBI chr 2:116,598,511...116,903,886
Ensembl chr 2:116,599,387...116,903,854

G

kinase insert domain receptor

multiple interactions
affects expression

ISO
EXP

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]
Curcumin affects the expression of KDR mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]
Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]

PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

Kelch-like ECH-associated protein 1

multiple interactions
decreases expression
increases expression

ISO
EXP

Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin results in decreased expression of KEAP1 mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]
Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein
Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of KEAP1 mRNA]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
Curcumin results in increased expression of KEAP1 mRNA

PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 More...

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

EXP

[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,903,033...32,978,812

G

KLF transcription factor 10

decreases expression

ISO

Curcumin results in decreased expression of KLF10 mRNA

NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:71,350,573...71,358,948

G

KLF transcription factor 6

increases expression

ISO

Curcumin results in increased expression of KLF6 mRNA

NCBI chr17:69,449,483...69,458,478
Ensembl chr17:69,441,493...69,498,601

G

kelch-like family member 21

increases expression

ISO

Curcumin results in increased expression of KLHL21 mRNA

NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:167,797,591...167,806,276

G

kelch-like family member 24

decreases expression

ISO

Curcumin results in decreased expression of KLHL24 mRNA

NCBI chr11:94,348,024...94,382,085
Ensembl chr11:94,351,157...94,382,050

G

kallikrein 1-related peptidase C10

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of KLK3 mRNA; Curcumin results in decreased expression of KLK3 protein
Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of KLK3 protein; trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA]

PMID:12497104 PMID:18676361 PMID:18719366 PMID:21134073 PMID:22258452

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

lysine methyltransferase 5A

decreases expression

ISO

Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein

NCBI chr12:37,800,339...37,823,706
Ensembl chr12:37,800,344...37,823,783

G

KRAS proto-oncogene, GTPase

decreases expression
multiple interactions

ISO

Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA
Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

PMID:17041101 PMID:21519798

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

keratin associated protein 2-1

decreases expression

ISO

Curcumin results in decreased expression of KRTAP2-1 mRNA

NCBI chr10:85,068,302...85,068,694

G

kynureninase

increases expression

ISO

Curcumin results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:48,188,182...48,339,014

G

lysosomal-associated membrane protein 1

affects expression
multiple interactions

EXP
ISO

Curcumin affects the expression of LAMP1 mRNA
Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]

PMID:18539377 PMID:34758851

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

lipopolysaccharide binding protein

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA]

NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518

G

lipocalin 2

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of LCN2 mRNA]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein]

PMID:18200517 PMID:25119790 PMID:29421648 PMID:38056816

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lymphocyte cytosolic protein 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA]

NCBI chr15:56,846,375...56,954,090
Ensembl chr15:56,847,433...56,954,092

G

lymphocyte cytosolic protein 2

increases expression

ISO

Curcumin results in increased expression of LCP2 mRNA

NCBI chr10:19,146,846...19,193,750
Ensembl chr10:19,146,554...19,193,744

G

lactate dehydrogenase A

multiple interactions
decreases expression

ISO
EXP

ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein]
Curcumin inhibits the reaction [Gentamicins results in increased expression of LDHA protein]

PMID:36640941 PMID:36924976 PMID:38056816

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

low density lipoprotein receptor

multiple interactions
affects expression
increases expression

ISO

Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein
Curcumin affects the expression of LDLR mRNA
Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein

PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

lymphoid enhancer binding factor 1

increases expression
multiple interactions

EXP

Curcumin results in increased expression of LEF1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA]

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

legumain

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]

NCBI chr 6:127,308,913...127,347,355
Ensembl chr 6:127,308,913...127,347,328

G

luteinizing hormone subunit beta

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LIM homeobox 5

affects expression

EXP

Curcumin affects the expression of LHX5 mRNA

NCBI chr12:41,786,746...41,795,183
Ensembl chr12:41,786,746...41,795,183

G

DNA ligase 3

multiple interactions

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein]

NCBI chr10:68,215,371...68,238,705
Ensembl chr10:68,215,407...68,238,704

G

DNA ligase 4

multiple interactions

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein]

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926

G

lipase C, hepatic type

affects expression

ISO

Curcumin affects the expression of LIPC mRNA

NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285

G

lysyl oxidase

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA]

NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810

G

lysophosphatidic acid receptor 1

decreases expression

ISO

Curcumin results in decreased expression of LPAR1 mRNA

NCBI chr 5:78,024,139...78,147,071
Ensembl chr 5:78,024,139...78,142,188

G

lipoprotein lipase

affects expression

ISO

Curcumin affects the expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

LDL receptor related protein 5

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA]
Curcumin results in increased expression of LRP5 mRNA

NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822

G

LDL receptor related protein 6

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA]
Curcumin results in increased expression of LRP6 mRNA

NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:169,000,968...169,131,716

G

leucine rich repeat neuronal 3

increases expression

ISO

Curcumin results in increased expression of LRRN3 mRNA

NCBI chr 6:64,216,164...64,247,293
Ensembl chr 6:64,215,878...64,247,614

G

lanosterol synthase

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of LSS mRNA
Curcumin results in decreased expression of LSS mRNA

NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253

G

lymphotoxin alpha

decreases expression
multiple interactions
increases expression

ISO

Curcumin results in decreased expression of LTA mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein
Curcumin results in increased expression of LTA mRNA

PMID:16101141 PMID:17198877 PMID:27430728

NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,623,527...3,625,533

G

lymphotoxin beta

increases expression
decreases expression

ISO

Curcumin results in increased expression of LTB mRNA
Curcumin results in decreased expression of LTB mRNA

PMID:16751071 PMID:17198877

NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054

G

lymphotoxin beta receptor

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of LTBR mRNA]

NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:159,795,115...159,807,296

G

lysozyme 2

multiple interactions
affects expression

ISO
EXP

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LYZ mRNA]
Curcumin affects the expression of LYZ2 mRNA

PMID:18200517 PMID:18539377

NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011

G

mucosal vascular addressin cell adhesion molecule 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA]

NCBI chr 7:10,686,920...10,690,322
Ensembl chr 7:10,686,250...10,690,322

G

monoamine oxidase A

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA]

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

ISO

Curcumin promotes the reaction [sodium arsenite results in increased lipidation of and results in increased localization of MAP1LC3A protein]

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

microtubule-associated protein 1 light chain 3 beta

increases lipidation
multiple interactions
increases localization
decreases expression
increases expression

ISO
EXP

Curcumin results in increased lipidation of MAP1LC3B protein
Curcumin promotes the reaction [sodium arsenite results in increased lipidation of and results in increased localization of MAP1LC3B protein]
MIR206 affects the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]
Curcumin results in increased localization of MAP1LC3B protein
Curcumin results in decreased expression of MAP1LC3B protein
Curcumin results in increased expression of MAP1LC3B mRNA
3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 3-nitropropionic acid inhibits the reaction [Curcumin results in increased localization of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; U 0126 inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]

PMID:34634291 PMID:36640941 PMID:37634662 PMID:38141737 PMID:38764151

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 2

multiple interactions

ISO

MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940

G

mitogen activated protein kinase kinase 3

increases expression

ISO

Curcumin results in increased expression of MAP2K3 mRNA

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:46,106,548...46,129,004

G

mitogen activated protein kinase kinase 4

decreases expression
increases phosphorylation

ISO

Curcumin results in decreased expression of MAP2K4 mRNA
Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix

CTD
RGD

PMID:15713895 PMID:25198898

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA]
Curcumin results in decreased expression of MAP3K1 mRNA

PMID:15713895 PMID:17148446 PMID:23452621

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897

G

mitogen-activated protein kinase kinase kinase 5

increases phosphorylation
multiple interactions

ISO

Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix
Curcumin inhibits the reaction [Cisplatin results in increased phosphorylation of MAP3K5 protein]

CTD
RGD

PMID:36178099 PMID:25198898

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

ISO
EXP

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein]
Curcumin results in decreased expression of MAPK1 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

EXP

Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK10 protein]

PMID:24952339 PMID:27535828 PMID:27966075

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen-activated protein kinase 11

multiple interactions

ISO

Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK11 protein]

NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038

G

mitogen-activated protein kinase 12

increases activity
multiple interactions

ISO

Curcumin results in increased activity of MAPK12 protein
Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK12 protein]

PMID:21594647 PMID:38141737

NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:122,085,913...122,096,307

G

mitogen activated protein kinase 13

multiple interactions

ISO

Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK13 protein]

NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,837,013...6,847,191

G

mitogen activated protein kinase 14

multiple interactions

ISO

Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK14 protein]

PMID:17151092 PMID:18357586 PMID:31521693 PMID:38141737

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation
decreases expression
decreases activity

ISO
EXP

[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]
Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein]
Curcumin results in decreased expression of MAPK3 protein

PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation
decreases phosphorylation
increases expression

ISO
EXP

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK8 mRNA]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]
Curcumin increases phosphorylation of MAPK8 protein in uterine cervix
Curcumin results in decreased phosphorylation of MAPK8 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein
Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
Curcumin results in increased expression of MAPK8 mRNA
Curcumin results in increased phosphorylation of MAPK8 protein

CTD
RGD

PMID:11981161 PMID:16101141 PMID:16678799 PMID:16934299 PMID:17372590 More...

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]
Curcumin results in decreased phosphorylation of MAPK9 protein
Curcumin results in increased phosphorylation of MAPK9 protein
Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 protein

PMID:11981161 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 More...

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein tau

multiple interactions

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of MAPT mRNA]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

membrane associated ring-CH-type finger 6

increases expression

ISO

Curcumin results in increased expression of MARCHF6 mRNA

NCBI chr 2:84,166,570...84,243,817
Ensembl chr 2:84,166,570...84,243,792

G

myelin basic protein

multiple interactions

ISO

Curcumin inhibits the reaction [Cuprizone results in decreased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of MCL1 protein alternative form
[Curcumin co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein

PMID:18829502 PMID:34675983

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

minichromosome maintenance complex component 2

decreases expression

EXP

Curcumin results in decreased expression of MCM2 mRNA

NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094

G

minichromosome maintenance complex component 7

decreases expression

ISO

Curcumin results in decreased expression of MCM7 mRNA

NCBI chr12:22,155,921...22,163,320
Ensembl chr12:22,155,921...22,163,771

G

MDM2 proto-oncogene

decreases expression
increases expression
multiple interactions

ISO

[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 protein
Curcumin analog results in increased expression of MDM2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein]

PMID:17332326 PMID:24831732 PMID:26409325

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

methyl CpG binding protein 2

decreases expression

ISO

Curcumin results in decreased expression of MECP2 protein

NCBI chr X:156,932,481...156,995,981
Ensembl chr X:156,941,234...156,943,560

G

myocyte enhancer factor 2C

decreases expression

ISO

Curcumin results in decreased expression of MEF2C mRNA

NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640

G

melanotransferrin

decreases expression

ISO

Curcumin results in decreased expression of MELTF mRNA

NCBI chr11:82,389,420...82,411,270
Ensembl chr11:82,389,420...82,411,270

G

mitofusin 1

increases expression

EXP

Curcumin results in increased expression of MFN1 protein

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

increases expression

ISO

Curcumin results in increased expression of MFNG mRNA

NCBI chr 7:112,191,288...112,209,129
Ensembl chr 7:112,161,071...112,209,129

G

O-6-methylguanine-DNA methyltransferase

decreases expression
increases expression
decreases activity
multiple interactions

ISO

Curcumin results in decreased expression of MGMT mRNA
Curcumin results in increased expression of MGMT mRNA
Curcumin results in decreased activity of MGMT protein
Curcumin results in increased expression of and results in increased activity of MGMT protein

PMID:16950796 PMID:17596214

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 1

increases expression

EXP

Curcumin results in increased expression of MGST1 mRNA

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

microRNA 125a

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of MIR125A mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR125A mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

PMID:29723631 PMID:33952798

NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:67,350,675...67,350,759

G

microRNA 146a

multiple interactions

ISO

Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]

NCBI chr10:28,349,996...28,350,090

G

microRNA 19a

multiple interactions

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA]

NCBI chr15:98,588,131...98,588,212
Ensembl chr15:98,588,131...98,588,212

G

microRNA 206

increases expression
multiple interactions

EXP

Curcumin results in increased expression of MIR206 mRNA
MIR206 affects the reaction [Curcumin results in decreased expression of SQSTM1 protein]; MIR206 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR206 affects the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; MIR206 affects the reaction [Curcumin results in increased expression of BECN1 protein]; MIR206 affects the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]

NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:30,590,697...30,590,780

G

microRNA 21

decreases expression

ISO

Curcumin results in decreased expression of MIR21 mRNA

NCBI chr10:71,902,600...71,902,691

G

microRNA 22

increases expression

ISO

Curcumin results in increased expression of MIR22

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425

G

microRNA 222

decreases expression

ISO

Curcumin results in decreased expression of MIR222 mRNA

NCBI chr X:6,022,621...6,022,723
Ensembl chr X:6,022,621...6,022,723

G

microRNA 223

increases expression

ISO

Curcumin results in increased expression of MIR223 mRNA

NCBI chr X:65,151,383...65,151,492
Ensembl chr X:65,151,383...65,151,492

G

microRNA 27a

decreases expression

ISO

Curcumin results in decreased expression of MIR27A mRNA

NCBI chr19:40,859,603...40,859,689

G

microRNA 27b

decreases expression

ISO

Curcumin results in decreased expression of MIR27B mRNA

NCBI chr17:1,819,147...1,819,243

G

microRNA 30a

increases expression

ISO

Curcumin results in increased expression of MIR30A mRNA

NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:33,233,941...33,234,011

G

microRNA 34a

multiple interactions

EXP

Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA]

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053

G

microRNA 532

increases expression
multiple interactions

ISO

Curcumin results in increased expression of MIR532 mRNA
MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]

NCBI chr X:17,919,185...17,919,263
Ensembl chr X:17,919,185...17,919,263

G

microRNA 802

multiple interactions

EXP

Curcumin inhibits the reaction [Acetaminophen results in increased expression of MIR802 mRNA]

NCBI chr11:46,112,362...46,112,457
Ensembl chr11:46,112,362...46,112,457

G

microRNA 99a

multiple interactions

ISO

Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of MIR99A mRNA]

NCBI chr11:29,687,392...29,687,472
Ensembl chr11:29,687,392...29,687,472

G

marker of proliferation Ki-67

multiple interactions
decreases expression

ISO
EXP

[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein
Curcumin inhibits the reaction [Lamotrigine results in decreased expression of MKI67 protein]
Curcumin results in decreased expression of MKI67 protein

PMID:17440100 PMID:18226269 PMID:19372569 PMID:38050455 PMID:38348716

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

membrane metallo-endopeptidase

decreases expression

ISO

Curcumin results in decreased expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463

G

matrix metallopeptidase 1

multiple interactions

ISO

Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 10

increases expression

ISO

Curcumin results in increased expression of MMP10 mRNA

NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613

G

matrix metallopeptidase 13

multiple interactions

ISO

Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

matrix metallopeptidase 14

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of MMP14 protein
Curcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]

PMID:16934674 PMID:18200517 PMID:18495463

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893

G

matrix metallopeptidase 2

decreases expression
multiple interactions
decreases activity
increases activity

ISO
EXP

Curcumin results in decreased expression of MMP2 protein
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]
Curcumin results in decreased activity of MMP2 protein
Curcumin results in increased activity of MMP2 protein
Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP2 mRNA]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]

PMID:16934674 PMID:17531121 PMID:17996675 PMID:18200517 PMID:18226269 More...

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 3

increases expression

ISO

Curcumin results in increased expression of MMP3 mRNA

PMID:15713895 PMID:18321735

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826

G

matrix metallopeptidase 7

multiple interactions

ISO

Curcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]; Curcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]

PMID:17928719 PMID:23452621

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

matrix metallopeptidase 9

multiple interactions
decreases activity
decreases expression
increases activity
affects expression

ISO
EXP

3-caffeoyl-4-dihydrocaffeoylquinic acid promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin promotes the reaction [3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin results in decreased secretion of and results in decreased activity of MMP9 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]
Curcumin results in decreased activity of MMP9 protein
Curcumin results in increased activity of MMP9 protein
Curcumin affects the expression of MMP9 mRNA; Curcumin affects the expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP9 protein]; [Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA]

PMID:16219905 PMID:16243823 PMID:17291458 PMID:17440100 PMID:17531121 More...

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

M phase phosphoprotein 6

decreases expression

ISO

Curcumin results in decreased expression of MPHOSPH6 mRNA

NCBI chr19:62,768,909...62,778,874
Ensembl chr19:62,768,909...62,778,950

G

myeloperoxidase

multiple interactions
decreases activity

EXP
ISO

Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]]
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of MPO protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of MPO protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MPO protein]
Curcumin analog results in decreased activity of MPO protein
Curcumin results in decreased activity of MPO protein

PMID:16804969 PMID:16867261 PMID:17276891 PMID:17351913 PMID:17373747 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrial ribosomal protein L1

increases expression

ISO

Curcumin results in increased expression of MRPL1 mRNA

NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,604,499...13,663,602

G

mitochondrial ribosomal protein L47

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MRPL47 mRNA]

NCBI chr 2:117,436,199...117,447,790
Ensembl chr 2:117,428,621...117,447,517

G

membrane spanning 4-domains A1

decreases expression
increases expression

ISO

Curcumin results in decreased expression of MS4A1 mRNA
Curcumin results in increased expression of MS4A1 mRNA

PMID:17198877 PMID:18421014

NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:217,331,274...217,343,447

G

methylsterol monooxygenase 1

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of MSMO1 mRNA
Curcumin results in decreased expression of MSMO1 mRNA

NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445

G

moesin

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]

NCBI chr X:65,005,546...65,073,512
Ensembl chr X:65,005,458...65,075,129

G

macrophage scavenger receptor 1

multiple interactions

ISO

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MSR1 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070

G

methionine sulfoxide reductase A

multiple interactions

ISO

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MSRA protein]

NCBI chr15:42,514,818...42,853,278
Ensembl chr15:42,527,045...42,853,279

G

methionine sulfoxide reductase B2

multiple interactions

ISO

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MSRB2 protein]

NCBI chr17:86,882,750...86,908,392
Ensembl chr17:86,882,394...86,908,391

G

macrophage stimulating 1 receptor

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]
Curcumin results in decreased expression of MST1R mRNA; Curcumin results in decreased expression of MST1R protein

NCBI chr 8:117,471,928...117,491,059
Ensembl chr 8:117,475,968...117,490,515

G

mitochondrially encoded cytochrome c oxidase I

decreases expression

ISO

Curcumin results in decreased expression of COX1 mRNA

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,309...6,853

G

mitochondrially encoded cytochrome c oxidase II

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of COX2 mRNA
3-methyladenine inhibits the reaction [Curcumin results in decreased expression of COX2 protein]; Curcumin results in increased degradation of and results in decreased expression of COX2 protein

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

decreases expression

ISO

Curcumin results in decreased expression of ND1 mRNA

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685

G

metallothionein 1A

multiple interactions
increases expression

EXP

Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT1A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MT1 protein]
Curcumin results in increased expression of MT1A mRNA

PMID:20229497 PMID:31199764

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

multiple interactions
increases expression

EXP

Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]
Curcumin results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions
decreases expression

ISO
EXP

Curcumin results in decreased phosphorylation of MTOR protein
MIR206 affects the reaction [Curcumin results in decreased phosphorylation of MTOR protein]
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein]
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of MTOR protein]; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of MTOR protein
Curcumin analog results in decreased expression of MTOR mRNA; Curcumin results in decreased expression of MTOR mRNA

PMID:20554536 PMID:21450334 PMID:26409325 PMID:27363783 PMID:33582110 More...

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

mevalonate diphosphate decarboxylase

decreases expression

ISO

Curcumin results in decreased expression of MVD mRNA

NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366

G

mevalonate kinase

affects expression
decreases expression

ISO
EXP

Curcumin affects the expression of MVK mRNA
Curcumin results in decreased expression of MVK mRNA

NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503

G

max dimerization protein 1

increases expression

ISO

Curcumin results in increased expression of MXD1 mRNA

NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:120,654,731...120,675,129

G

Max dimerization protein 3

decreases expression

ISO

Curcumin results in decreased expression of MXD3 mRNA

PMID:15713895 PMID:17198877

NCBI chr17:9,306,552...9,310,278
Ensembl chr17:9,302,321...9,310,278

G

myosin binding protein C3

multiple interactions

EXP

Curcumin inhibits the reaction [Gentamicins results in increased expression of MYBPC3 mRNA]

NCBI chr 3:97,550,974...97,569,216
Ensembl chr 3:97,551,061...97,569,216

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

ISO

[Curcumin co-treated with Doxorubicin] affects the expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]
[Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein; Curcumin inhibits the reaction [Cisplatin results in decreased phosphorylation of MYC protein]
Curcumin results in increased expression of MYC mRNA
Curcumin analog results in decreased expression of MYC protein; Curcumin results in decreased expression of MYC mRNA; Curcumin results in decreased expression of MYC protein

PMID:15713895 PMID:15911101 PMID:16219905 PMID:16243823 PMID:17041101 More...

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

MYD88, innate immune signal transduction adaptor

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]
Curcumin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of MYD88 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]

PMID:19002562 PMID:23452621 PMID:34719837 PMID:36178099

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

myosin heavy chain 1

decreases expression

EXP

Curcumin results in decreased expression of MYH1 mRNA

NCBI chr10:52,384,810...52,408,698
Ensembl chr10:52,384,908...52,409,047

G

myosin heavy chain 6

decreases expression

ISO

Curcumin results in decreased expression of MYH6 mRNA

NCBI chr15:32,388,102...32,413,663
Ensembl chr15:32,387,487...32,411,333

G

myosin heavy chain 7

multiple interactions
decreases expression

EXP

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of MYH7 mRNA]; Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]

PMID:25093688 PMID:26612707

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin light chain 12A

increases expression

ISO

Curcumin results in increased expression of MYL12A mRNA

NCBI chr 9:118,338,592...118,346,277
Ensembl chr 9:118,338,604...118,342,634

G

myosin, light chain 4

decreases expression

ISO

Curcumin results in decreased expression of MYL4 mRNA

NCBI chr10:89,949,733...89,985,308
Ensembl chr10:89,949,404...89,985,308

G

myosin light chain 9

multiple interactions

ISO

Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYL9 protein modified form]

NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:165,742,046...165,748,410

G

myosin light chain kinase

increases expression
multiple interactions

ISO

Curcumin results in increased expression of MYLK mRNA
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK protein]

PMID:21594647 PMID:35817260

NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659

G

myosin XVIIIa

increases expression

ISO

Curcumin results in increased expression of MYO18A mRNA

NCBI chr10:63,152,303...63,253,543
Ensembl chr10:63,152,103...63,253,543

G

NLR family, apoptosis inhibitory protein 6

decreases expression
multiple interactions

ISO

Curcumin analog results in decreased expression of NAIP mRNA; Curcumin results in decreased expression of NAIP mRNA
[Curcumin co-treated with Doxorubicin] affects the expression of NAIP mRNA; [Curcumin co-treated with Oxygen deficiency] results in decreased expression of NAIP protein

PMID:15911101 PMID:17671737 PMID:19250217 PMID:23452621

NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:33,241,521...33,276,859

G

Nanog homeobox

multiple interactions
increases expression

ISO

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA]
Curcumin results in increased expression of NANOG mRNA; Curcumin results in increased expression of NANOG protein

PMID:25822711 PMID:27237783

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

nanos C2HC-type zinc finger 1

decreases expression

ISO

Curcumin results in decreased expression of NANOS1 mRNA

NCBI chr 1:269,883,713...269,887,611
Ensembl chr 1:269,883,536...269,895,417

G

neural cell adhesion molecule 1

increases expression

EXP

Curcumin results in increased expression of NCAM1 protein modified form

NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971

G

nuclear receptor coactivator 1

multiple interactions

ISO

Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]

NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:32,952,090...33,195,924

G

neurofilament medium chain

increases expression

EXP

Curcumin results in increased expression of NEFM mRNA

NCBI chr15:46,535,857...46,541,161
Ensembl chr15:46,535,517...46,541,163

G

nei-like DNA glycosylase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]; Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein]

NCBI chr 8:66,446,106...66,452,844
Ensembl chr 8:66,445,953...66,452,378

G

nestin

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA]; Curcumin inhibits the reaction [Gentamicins results in increased expression of NES mRNA]
Curcumin results in increased expression of NES mRNA

PMID:25963729 PMID:38056816

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228

G

neuronal differentiation 1

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA]
Curcumin results in increased expression of NEUROD1 mRNA

NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:84,764,725...84,770,810

G

neurogenin 1

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA]
Curcumin results in increased expression of NEUROG1 mRNA

NCBI chr17:8,368,096...8,369,615
Ensembl chr17:8,368,096...8,369,615

G

NFE2 like bZIP transcription factor 1

increases expression

ISO

Curcumin results in increased expression of NFE2L1 protein

NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases methylation
affects localization
increases localization
increases expression
decreases response to substance
increases activity

ISO
EXP

[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; Curcumin inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]
Curcumin analog results in decreased methylation of NFE2L2 promoter
Curcumin affects the localization of NFE2L2 protein; Curcumin analog affects the localization of NFE2L2 protein
Curcumin results in increased localization of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Gentamicins results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]
Curcumin analog results in increased expression of NFE2L2 mRNA; Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Curcumin results in increased expression of and results in increased localization of NFE2L2 protein; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]
NFE2L2 gene mutant form results in decreased susceptibility to Curcumin
Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 protein modified form
Curcumin results in increased activity of NFE2L2 protein

PMID:17449203 PMID:17535857 PMID:17640564 PMID:18006204 PMID:18321868 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
decreases activity
decreases expression
decreases localization

ISO
EXP

Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]
Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein
[Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKB1 protein]
Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA]
Curcumin results in decreased expression of NFKB1 protein
Curcumin results in decreased localization of NFKB1 protein

PMID:15489888 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nuclear factor kappa B subunit 2

decreases activity

ISO

Curcumin results in decreased activity of NFKB2 protein

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637

G

NFKB inhibitor alpha

multiple interactions
decreases phosphorylation
increases expression
decreases expression

ISO
EXP

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin inhibits the reaction [Fluorouracil results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
Curcumin results in decreased phosphorylation of NFKBIA protein
Curcumin results in increased expression of NFKBIA protein
CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Freund's Adjuvant results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Curcumin results in decreased expression of NFKBIA protein

PMID:12216086 PMID:15489888 PMID:15793857 PMID:16023083 PMID:16219905 More...

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor beta

multiple interactions

EXP

Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

nuclear transcription factor Y subunit alpha

decreases expression

ISO

Curcumin results in decreased expression of NFYA mRNA

NCBI chr 9:20,085,067...20,111,521
Ensembl chr 9:20,085,073...20,111,504

G

nerve growth factor receptor

decreases expression

ISO

Curcumin results in decreased expression of NGFR mRNA

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

NHL repeat containing 2

decreases expression

ISO

Curcumin results in decreased expression of NHLRC2 mRNA

NCBI chr 1:265,594,915...265,655,647
Ensembl chr 1:265,594,915...265,676,143

G

NK2 homeobox 5

decreases expression

ISO

Curcumin results in decreased expression of NKX2-5 mRNA

NCBI chr10:16,844,888...16,851,458
Ensembl chr10:16,848,582...16,851,452

G

NK3 homeobox 1

decreases expression

ISO

Curcumin results in decreased expression of NKX3-1 mRNA; Curcumin results in decreased expression of NKX3-1 protein

PMID:17303007 PMID:18719366

NCBI chr15:50,883,661...50,886,253
Ensembl chr15:50,883,597...50,886,251

G

NLR family, pyrin domain containing 12

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]

NCBI chr 1:74,848,020...74,885,945
Ensembl chr 1:74,848,063...74,876,341

G

NLR family, pyrin domain containing 3

multiple interactions

ISO
EXP

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of NLRP3 protein]
Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of NLRP3 mRNA]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of NLRP3 mRNA]

PMID:34998855 PMID:35063475 PMID:38301994 PMID:38369055

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

ISO

Curcumin results in increased expression of NME1 mRNA

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

N-myristoyltransferase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NMT2 mRNA]

NCBI chr17:79,826,999...79,874,088
Ensembl chr17:79,826,999...79,870,259

G

nucleotide-binding oligomerization domain containing 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]

NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:85,391,151...85,441,674

G

nucleotide-binding oligomerization domain containing 2

multiple interactions

ISO

Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]]

NCBI chr19:34,555,832...34,596,281
Ensembl chr19:34,555,832...34,722,846

G

non-POU domain containing, octamer-binding

multiple interactions

ISO

Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NONO mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NONO protein]

NCBI chr X:70,594,116...70,611,976
Ensembl chr X:70,593,888...70,611,979

G

nitric oxide synthase 1

multiple interactions

EXP
ISO

Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS1 protein]

PMID:17627722 PMID:24662163

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

nitric oxide synthase 2

multiple interactions
decreases activity
affects expression
affects activity

ISO
EXP

Curcumin inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [quinocetone results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Curcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]
Curcumin results in decreased activity of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]]
Curcumin affects the expression of NOS2 mRNA
Curcumin affects the activity of NOS2 protein

PMID:7530002 PMID:12628514 PMID:16934299 PMID:17373747 PMID:17434272 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

multiple interactions

ISO

Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein]

PMID:18660423 PMID:23452621

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 protein
[Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein

PMID:17927689 PMID:18640131

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

NADPH oxidase 4

multiple interactions

EXP

Curcumin inhibits the reaction [Cyclosporine results in increased expression of NOX4 protein]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

NPC1 like intracellular cholesterol transporter 1

multiple interactions

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein]

NCBI chr14:85,285,387...85,305,050
Ensembl chr14:85,285,390...85,305,050

G

NPC intracellular cholesterol transporter 2

decreases expression

ISO

Curcumin results in decreased expression of NPC2 mRNA

NCBI chr 6:110,128,325...110,149,245
Ensembl chr 6:110,128,325...110,150,004

G

NPL4 homolog, ubiquitin recognition factor

increases expression

ISO

Curcumin results in increased expression of NPLOC4 mRNA; Curcumin results in increased expression of NPLOC4 protein

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:106,153,173...106,208,264

G

natriuretic peptide A

multiple interactions
decreases expression

EXP

carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

NAD(P)H quinone dehydrogenase 1

increases expression
increases activity
multiple interactions

EXP
ISO

Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin results in increased activity of NQO1 protein
Curcumin analog results in increased expression of NQO1 mRNA; Curcumin analog results in increased expression of NQO1 protein; Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein
Curcumin analog inhibits the reaction [Rotenone results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein]
[Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein; Curcumin affects the expression of and results in increased activity of NQO1 protein; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NQO1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]

PMID:12628514 PMID:17198877 PMID:17535857 PMID:18299980 PMID:18321868 More...

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group H, member 3

increases expression
multiple interactions

ISO

Curcumin results in increased expression of NR1H3 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 protein]
[Curcumin cotreated with oxidized LDL] increases expression of Nr1h3 protein in macrophages

CTD
RGD

PMID:16713233 PMID:37701206 PMID:25064633

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

G

nuclear receptor subfamily 1, group I, member 2

increases activity
affects expression

ISO

Curcumin results in increased activity of NR1I2 protein
Curcumin affects the expression of NR1I2 mRNA

PMID:17210444 PMID:29933105

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

nuclear receptor subfamily 3, group C, member 1

increases expression
multiple interactions

EXP
ISO

Curcumin results in increased expression of NR3C1 mRNA
Curcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein]

PMID:17022948 PMID:18483179

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

ISO

Curcumin results in decreased expression of NR4A2 mRNA

NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769

G

nuclear receptor interacting protein 1

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of NRIP1 mRNA alternative form
NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA]

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353

G

netrin 1

multiple interactions

EXP

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of NTN1 protein]

NCBI chr10:53,398,852...53,597,595
Ensembl chr10:53,398,852...53,584,060

G

neurotrophic receptor tyrosine kinase 2

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein]

NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628

G

nucleoporin 98 and 96 precursor

increases expression

ISO

Curcumin results in increased expression of NUP98 mRNA

NCBI chr 1:165,906,405...166,003,366
Ensembl chr 1:165,906,405...166,003,366

G

ornithine aminotransferase

affects expression

EXP

Curcumin affects the expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

occludin

multiple interactions

ISO

Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

ornithine decarboxylase 1

increases expression
multiple interactions

ISO

Curcumin results in increased expression of ODC1 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

PMID:12628514 PMID:17198877

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

8-oxoguanine DNA glycosylase

multiple interactions

ISO

Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein]

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

oxidized low density lipoprotein receptor 1

multiple interactions

ISO

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA]

NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:164,612,463...164,634,598

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

EXP

Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein]

NCBI chr11:84,612,943...84,690,025
Ensembl chr11:84,615,340...84,689,955

G

OS9, endoplasmic reticulum lectin

increases expression

ISO

Curcumin results in increased expression of OS9 mRNA

NCBI chr 7:64,802,517...64,829,185
Ensembl chr 7:64,802,103...64,829,070

G

oncostatin M receptor

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA]

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

OTU deubiquitinase, ubiquitin aldehyde binding 1

decreases expression

ISO

Curcumin results in decreased expression of OTUB1 mRNA

NCBI chr 1:213,816,400...213,824,679
Ensembl chr 1:213,816,400...213,824,679

G

OTU deubiquitinase 7B

decreases expression

ISO

Curcumin results in decreased expression of OTUD7B mRNA

NCBI chr 2:186,350,811...186,411,461
Ensembl chr 2:186,350,798...186,409,440

G

phenylalanine hydroxylase

decreases expression

ISO

Curcumin results in decreased expression of PAH mRNA

NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627

G

p21 (RAC1) activated kinase 2

decreases cleavage

ISO

Curcumin results in decreased cleavage of PAK2 protein

NCBI chr11:82,212,896...82,273,803
Ensembl chr11:82,212,951...82,273,803

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases expression
decreases cleavage
decreases expression
increases cleavage
increases degradation

ISO
EXP

[Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein; arsenic trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [docetaxel results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [arsenic trioxide results in increased expression of PARP1 protein modified form]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; Curcumin results in increased cleavage of and results in increased activity of PARP1 protein
Curcumin results in decreased cleavage of PARP1 protein
Curcumin analog results in decreased expression of PARP1 mRNA
Curcumin results in increased cleavage of PARP1 protein
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
[Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein; Curcumin inhibits the reaction [Cisplatin results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Curcumin results in increased degradation of PARP1

PMID:11035063 PMID:14555224 PMID:14724571 PMID:15569404 PMID:16023083 More...

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

paired box 6

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA]
Curcumin results in increased expression of PAX6 mRNA

NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:112,590,391...112,611,763

G

phosphoenolpyruvate carboxykinase 1

decreases expression
affects expression

ISO

Curcumin results in decreased expression of PCK1 mRNA
Curcumin affects the expression of PCK1 mRNA

PMID:17198877 PMID:27208389

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

proliferating cell nuclear antigen

decreases expression
multiple interactions
increases expression

ISO
EXP

Curcumin results in decreased expression of PCNA protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of PCNA protein
[Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of PCNA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein]
Curcumin results in increased expression of PCNA mRNA

PMID:16101141 PMID:18226269 PMID:23222814 PMID:24831732 PMID:26612707 More...

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

proprotein convertase subtilisin/kexin type 9

affects expression

ISO

Curcumin affects the expression of PCSK9 mRNA

NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507

G

platelet derived growth factor subunit B

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]

PMID:18006644 PMID:18784349

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor beta

increases expression
decreases phosphorylation
multiple interactions
decreases expression

ISO
EXP

Curcumin results in increased expression of PDGFRB mRNA
Curcumin results in decreased phosphorylation of PDGFRB protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]
Curcumin results in decreased expression of PDGFRB mRNA; Curcumin results in decreased expression of PDGFRB protein

PMID:17372590 PMID:18006644 PMID:18332871 PMID:21594647

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

protein disulfide isomerase family A, member 3

increases expression

ISO

Curcumin results in increased expression of PDIA3 mRNA

NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:128,841,917...128,867,327

G

pyruvate dehydrogenase kinase 1

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145

G

3-phosphoinositide dependent protein kinase-1

decreases phosphorylation

ISO

Curcumin results in decreased phosphorylation of PDPK1 protein

NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181

G

podoplanin

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PDPN mRNA]

NCBI chr 5:160,884,995...160,919,112
Ensembl chr 5:160,884,993...160,925,637

G

platelet and endothelial cell adhesion molecule 1

affects expression
multiple interactions
increases expression
decreases expression

ISO
EXP

Curcumin affects the expression of PECAM1 protein
Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein]
Curcumin results in increased expression of PECAM1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein]
Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein]

PMID:17440100 PMID:17960570 PMID:23845850 PMID:29244817

NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839

G

period circadian regulator 2

increases expression

ISO

Curcumin results in increased expression of PER2 mRNA

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

decreases expression

ISO

Curcumin results in decreased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

phosphogluconate dehydrogenase

increases expression

EXP

Curcumin results in increased expression of PGD mRNA

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

placental growth factor

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PGF mRNA]

NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747

G

phosphatidylglycerophosphate synthase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PGS1 mRNA]

NCBI chr10:103,713,306...103,748,924
Ensembl chr10:103,713,316...103,749,233

G

prohibitin 1

decreases expression

ISO

Curcumin results in decreased expression of PHB1 protein

NCBI chr10:81,102,043...81,114,815
Ensembl chr10:81,102,028...81,116,233

G

phytanoyl-CoA 2-hydroxylase

decreases expression

EXP

Curcumin results in decreased expression of PHYH mRNA

NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

decreases expression

ISO

Curcumin analog results in decreased expression of PIK3C2A mRNA

NCBI chr 1:180,012,248...180,117,786
Ensembl chr 1:180,012,248...180,117,773

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

decreases expression

ISO

Curcumin analog results in decreased expression of PIK3CA mRNA

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

PTEN induced kinase 1

multiple interactions

EXP

Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein]

NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950

G

pirin

increases expression

EXP

Curcumin results in increased expression of PIR mRNA

NCBI chr X:33,740,428...33,851,049
Ensembl chr X:33,740,429...33,851,049

G

paired Ig-like receptor B

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LILRB3 mRNA]

NCBI chr 1:74,414,556...74,433,015
Ensembl chr 1:74,331,291...74,422,116

G

pyruvate kinase M1/2

multiple interactions

ISO

ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of PKM protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein]

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396

G

phospholipase A2 group IIA

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA]

NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297

G

plasminogen activator, urokinase

decreases secretion
multiple interactions
increases expression
decreases expression

ISO

Curcumin results in decreased secretion of PLAU protein
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein]
Curcumin results in increased expression of PLAU mRNA
TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]

PMID:18025290 PMID:18226269 PMID:18495463 PMID:35716765

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030

G

plasminogen activator, urokinase receptor

increases expression
multiple interactions

ISO

Curcumin results in increased expression of PLAUR mRNA
Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein]

PMID:15713895 PMID:35716765

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase C, gamma 1

multiple interactions

EXP

curcumin inhibits the reaction [azoxymethane increases activity of Plcg1 protein in colonic mucosa]

RGD

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

pleckstrin homology, MyTH4 and FERM domain containing H2

increases expression

ISO

Curcumin results in increased expression of PLEKHH2 mRNA

NCBI chr 6:15,783,179...15,893,479
Ensembl chr 6:15,784,645...15,893,537

G

polo-like kinase 1

decreases expression

ISO

Curcumin analog results in decreased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 2

increases expression

ISO

Curcumin analog results in increased expression of PLK2 mRNA

NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296

G

polo-like kinase 3

increases expression

ISO

Curcumin analog results in increased expression of PLK3 mRNA

NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:135,843,725...135,848,900

G

polo-like kinase 4

increases expression

ISO

Curcumin analog results in increased expression of PLK4 mRNA

NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:125,730,460...125,748,892

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLOD2 mRNA]

NCBI chr 8:101,964,318...102,047,022
Ensembl chr 8:101,964,318...102,047,022

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

ISO

Curcumin results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

prostate transmembrane protein, androgen induced 1

decreases expression

ISO

Curcumin results in decreased expression of PMEPA1 mRNA

NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649

G

DNA polymerase alpha 2, accessory subunit

decreases expression

EXP

Curcumin results in decreased expression of POLA2 mRNA

NCBI chr 1:212,656,500...212,680,667
Ensembl chr 1:212,656,501...212,680,542

G

DNA polymerase beta

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein]
Curcumin results in decreased expression of POLB protein

PMID:19401701 PMID:21332098

NCBI chr16:76,081,903...76,105,174
Ensembl chr16:76,081,864...76,108,180

G

DNA polymerase epsilon, catalytic subunit

decreases expression

EXP

Curcumin results in decreased expression of POLE mRNA

NCBI chr12:52,005,155...52,053,761
Ensembl chr12:52,005,155...52,053,662

G

porcupine O-acyltransferase

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of PORCN mRNA]
Curcumin results in increased expression of PORCN mRNA

NCBI chr X:16,957,811...16,970,440
Ensembl chr X:16,957,810...16,970,439

G

periostin

increases expression

ISO

Curcumin results in increased expression of POSTN mRNA

NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300

G

POU class 5 homeobox 1

multiple interactions
decreases expression
increases expression

ISO

2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]
Curcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 protein
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]
Curcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 protein

PMID:25822711 PMID:27237783 PMID:33539684

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598

G

peroxisome proliferator-activated receptor delta

decreases expression

ISO

Curcumin results in decreased expression of PPARD mRNA; Curcumin results in decreased expression of PPARD protein

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

affects binding
decreases expression
increases expression
increases activity
affects localization
multiple interactions

ISO
EXP

Curcumin binds to PPARG protein
Curcumin results in decreased expression of PPARG mRNA
Curcumin results in increased expression of PPARG mRNA; Curcumin results in increased expression of PPARG protein
Curcumin results in increased activity of PPARG protein
Curcumin results in decreased expression of PPARG protein
Curcumin affects the localization of PPARG protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Curcumin results in decreased expression of and results in decreased activity of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG protein]; bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lamotrigine results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]
PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
Curcumin results in decreased expression of PPARG protein modified form

PMID:15486348 PMID:15713005 PMID:16782535 PMID:16959952 PMID:17372590 More...

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; Curcumin inhibits the reaction [Potassium Dichromate results in decreased expression of PPARGC1A protein]
Curcumin results in increased expression of PPARGC1A protein

PMID:28951138 PMID:32980475

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

pancreatic progenitor cell differentiation and proliferation factor

increases expression

ISO

Curcumin results in increased expression of PPDPF mRNA

NCBI chr 3:188,676,821...188,678,599
Ensembl chr 3:188,676,965...188,678,599

G

peptidylprolyl isomerase F

increases expression

ISO

Curcumin results in increased expression of PPIF mRNA

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954

G

protein phosphatase 1 catalytic subunit alpha

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of PPP1CA protein]

NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:210,914,567...210,918,193

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of PPP1R1B protein]

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA]

NCBI chr10:36,856,534...36,878,789

G

protein phosphatase 3 catalytic subunit gamma

decreases expression

ISO

Curcumin results in decreased expression of PPP3CC mRNA

NCBI chr15:51,699,586...51,771,763
Ensembl chr15:51,700,255...51,771,538

G

protein phosphatase 5, catalytic subunit

multiple interactions

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C mRNA]

NCBI chr 1:86,818,297...86,842,505
Ensembl chr 1:86,818,297...86,842,950

G

peroxiredoxin 5

multiple interactions

ISO

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein]

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation

ISO

Curcumin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase C, alpha

multiple interactions
decreases expression

ISO

[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]
Curcumin analog results in decreased expression of PRKCA mRNA

PMID:17178710 PMID:18357586 PMID:26409325

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, delta

multiple interactions
affects binding
increases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Curcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein
Curcumin binds to PRKCD protein

PMID:17148446 PMID:17171638 PMID:18357586 PMID:19161989

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase C, epsilon

multiple interactions
decreases expression
decreases response to substance

ISO

Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]
Curcumin analog results in decreased expression of PRKCE mRNA
PRKCE protein results in decreased susceptibility to Curcumin

PMID:14742295 PMID:17148446 PMID:26409325

NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288

G

protein kinase C, eta

multiple interactions

ISO

Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:98,027,646...98,226,477

G

protein kinase C, theta

multiple interactions

EXP

Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein]

NCBI chr17:72,156,215...72,288,508
Ensembl chr17:72,156,215...72,288,508

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC protein]
Curcumin results in decreased expression of PRKDC mRNA

PMID:17596214 PMID:21332098

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

parkin RBR E3 ubiquitin protein ligase

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of PRKN mRNA
Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein]

PMID:28698153 PMID:38229314

NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304

G

prolactin receptor

increases expression

ISO

Curcumin results in increased expression of PRLR mRNA

NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882

G

prominin 1

multiple interactions
decreases expression

ISO

WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]
Curcumin results in decreased expression of PROM1 mRNA; Curcumin results in decreased expression of PROM1 protein

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

patched 1

multiple interactions

EXP

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]

NCBI chr17:1,548,449...1,613,461
Ensembl chr17:1,548,449...1,613,461

G

phosphatase and tensin homolog

multiple interactions

ISO

Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin E synthase

multiple interactions

ISO

Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]

NCBI chr 3:34,575,643...34,586,987
Ensembl chr 3:34,575,639...34,586,995

G

prostaglandin E synthase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGES2 protein]

NCBI chr 3:36,088,246...36,095,430
Ensembl chr 3:36,088,246...36,097,694

G

prostaglandin-endoperoxide synthase 1

decreases expression

ISO

Curcumin results in decreased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

decreases expression
increases expression
multiple interactions
affects expression

ISO
EXP

Curcumin analog results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 protein
Curcumin analog results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]
Curcumin results in increased expression of PTGS2 mRNA
[Curcumin co-treated with Azoxymethane] results in increased expression of PTGS2 mRNA; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]
Curcumin affects the expression of PTGS2 mRNA
[Fluorouracil co-treated with Curcumin] results in decreased expression of PTGS2 protein; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of PTGS2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]

PMID:15129424 PMID:15489888 PMID:15841493 PMID:15911101 PMID:16023083 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

parathyroid hormone-like hormone

multiple interactions

ISO

Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]

NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454

G

protein tyrosine phosphatase, non-receptor type 13

decreases expression

ISO

Curcumin results in decreased expression of PTPN13 mRNA

NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,412,841...6,587,171

G

protein tyrosine phosphatase, non-receptor type 6

increases expression

ISO

Curcumin results in increased expression of PTPN6 mRNA

NCBI chr 4:159,212,320...159,237,069
Ensembl chr 4:159,212,320...159,237,069

G

protein tyrosine phosphatase, non-receptor type 7

increases expression

ISO

Curcumin results in increased expression of PTPN7 mRNA

NCBI chr13:49,122,679...49,136,096
Ensembl chr13:49,122,609...49,136,094

G

protein tyrosine phosphatase, receptor type, O

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA]

NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:171,895,232...172,105,903

G

protein tyrosine phosphatase, receptor type, R

decreases expression

ISO

Curcumin results in decreased expression of PTPRR mRNA

NCBI chr 7:53,548,611...53,815,632
Ensembl chr 7:53,548,629...53,815,629

G

pentraxin 3

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA]

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

PYD and CARD domain containing

multiple interactions

ISO

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PYCARD mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of PYCARD mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of PYCARD protein]

PMID:35063475 PMID:38301994

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RAB8A, member RAS oncogene family

decreases expression

ISO

Curcumin results in decreased expression of RAB8A mRNA

NCBI chr16:17,688,049...17,709,412
Ensembl chr16:17,688,050...17,709,477

G

Rac family small GTPase 1

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of RAC1 mRNA]

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

RAD51 recombinase

multiple interactions

ISO

[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

Raf-1 proto-oncogene, serine/threonine kinase

increases activity
multiple interactions

ISO

Curcumin results in increased activity of RAF1 protein
piperlongumine inhibits the reaction [Curcumin results in increased activity of RAF1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

receptor activity modifying protein 1

decreases expression

ISO

Curcumin results in decreased expression of RAMP1 mRNA

NCBI chr 9:99,213,031...99,263,696

G

retinoic acid receptor, alpha

multiple interactions

ISO

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]

NCBI chr10:84,379,780...84,424,371
Ensembl chr10:84,389,622...84,425,160

G

Ras association domain family member 2

increases expression

ISO

Curcumin results in increased expression of RASSF2 mRNA

NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:139,697,187...139,733,368

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

ISO

Curcumin results in decreased phosphorylation of RB1 protein
Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein]

PMID:15738001 PMID:18156803 PMID:23222814

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RNA binding motif protein 39

increases expression

ISO

Curcumin results in increased expression of RBM39 mRNA

NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397

G

retinol binding protein 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA]

NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:107,887,417...107,983,847

G

regenerating family member 3 beta

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA]

NCBI chr 4:112,419,776...112,423,014
Ensembl chr 4:112,419,776...112,423,014

G

regenerating family member 3 gamma

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3G mRNA]

NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:112,482,183...112,484,738

G

REL proto-oncogene, NF-kB subunit

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of REL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]; Curcumin promotes the reaction [Hydrogen Peroxide results in increased expression of REL protein]
Curcumin results in increased expression of REL protein

PMID:23452621 PMID:31521693

NCBI chr14:101,891,238...101,922,324
Ensembl chr14:101,891,243...101,921,938

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
increases activity
affects activity
increases expression
decreases localization
decreases activity

ISO
EXP

[Curcumin co-treated with Isoflavones] results in decreased activity of RELA protein; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Acids results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of RELA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of RELA protein modified form]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA]; Curcumin inhibits the reaction [Formaldehyde results in increased expression of RELA protein]; Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]; Curcumin inhibits the reaction [Sodium Fluoride results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Curcumin results in decreased expression of and results in decreased activity of RELA protein; Curcumin results in decreased phosphorylation of and affects the localization of RELA protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]]
[Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein; Curcumin analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of RELA protein]; Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]; Curcumin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
Curcumin results in decreased expression of RELA protein
Curcumin results in increased activity of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of and results in decreased phosphorylation of RELA protein; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Chitosan promotes the reaction [Curcumin inhibits the reaction [fenpropathrin results in increased expression of RELA mRNA]]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Gentamicins results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of RELA protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]; Curcumin results in increased expression of and results in increased activity of RELA protein; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]]
Curcumin affects the activity of RELA protein
Curcumin results in increased expression of RELA
Curcumin results in decreased localization of RELA protein
Curcumin results in decreased expression of RELA; Curcumin results in decreased expression of RELA mRNA; Curcumin results in decreased expression of RELA protein

PMID:12216086 PMID:12388107 PMID:15489888 PMID:15911101 PMID:16023083 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELB mRNA]

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

reelin

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]
Curcumin results in increased expression of RELN mRNA

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162

G

resistin like beta

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RETNLB mRNA]

NCBI chr11:65,446,433...65,448,319
Ensembl chr11:65,446,434...65,448,319

G

REV3 like, DNA directed polymerase zeta catalytic subunit

increases expression

ISO

Curcumin results in increased expression of REV3L protein

NCBI chr20:44,686,482...44,844,668
Ensembl chr20:44,686,940...44,844,668

G

regulatory factor X-associated protein

decreases expression

ISO

Curcumin results in decreased expression of RFXAP mRNA

NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:141,158,215...141,162,397

G

regulator of G-protein signaling 16

increases expression

ISO

Curcumin results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

regulator of G-protein signaling 4

decreases expression

ISO

Curcumin results in decreased expression of RGS4 mRNA

NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884

G

regulator of G-protein signaling 7

decreases expression

ISO

Curcumin results in decreased expression of RGS7 mRNA

NCBI chr13:89,511,492...89,941,082
Ensembl chr13:89,511,150...89,940,987

G

ras homolog family member A

decreases expression

ISO

Curcumin analog results in decreased expression of RHOA mRNA

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

ras homolog family member B

decreases expression

ISO

Curcumin analog results in decreased expression of RHOB mRNA

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

regulating synaptic membrane exocytosis 2

decreases expression

ISO

Curcumin results in decreased expression of RIMS2 mRNA

NCBI chr 7:72,133,004...72,644,059
Ensembl chr 7:72,133,170...72,645,499

G

receptor interacting serine/threonine kinase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA]

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

ring finger protein 103

increases expression

ISO

Curcumin results in increased expression of RNF103 mRNA

NCBI chr 4:105,084,762...105,100,839
Ensembl chr 4:105,084,686...105,106,809

G

ring finger protein 122

increases expression

ISO

Curcumin results in increased expression of RNF122 mRNA

NCBI chr16:67,712,936...67,730,479
Ensembl chr16:67,712,936...67,730,479

G

ring finger protein 180

decreases expression

ISO

Curcumin results in decreased expression of RNF180 mRNA

NCBI chr 2:38,064,026...38,244,854
Ensembl chr 2:38,064,031...38,265,358

G

ring finger protein 185

increases expression

ISO

Curcumin results in increased expression of RNF185 mRNA

NCBI chr14:82,516,153...82,554,199
Ensembl chr14:82,516,154...82,553,466

G

RAR-related orphan receptor C

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of RORC mRNA]

NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566

G

ribosomal protein L31

increases expression

ISO

Curcumin results in increased expression of RPL31 mRNA

NCBI chr 9:49,143,044...49,147,155
Ensembl chr 9:49,142,955...49,147,155

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

ISO

calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]; Curcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein

PMID:18790744 PMID:21450334 PMID:23222814 PMID:34634291

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566

G

ribosomal protein S6 kinase B1

decreases phosphorylation
multiple interactions

ISO

Curcumin results in decreased phosphorylation of RPS6KB1 protein
Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein]
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of RPS6KB1 protein]

PMID:18790744 PMID:20554536 PMID:27363783 PMID:34634291

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

ras responsive element binding protein 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA]

NCBI chr17:27,082,217...27,208,061
Ensembl chr17:27,082,227...27,208,061

G

rhotekin

multiple interactions

ISO

Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Fluorouracil]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Paclitaxel]

NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660

G

RUNX family transcription factor 2

decreases expression

ISO

Curcumin results in decreased expression of RUNX2 protein

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

retinoid X receptor alpha

multiple interactions

ISO

Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

S100 calcium binding protein A8

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA]

NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221

G

S100 calcium binding protein A9

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA]

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

S100 calcium binding protein G

affects expression

EXP

Curcumin affects the expression of S100G mRNA

NCBI chr X:35,337,636...35,340,205
Ensembl chr X:35,337,675...35,340,205

G

scavenger receptor class B, member 1

affects expression

ISO

Curcumin affects the expression of SCARB1 mRNA

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

stearoyl-CoA desaturase

decreases expression
affects expression

ISO
EXP

Curcumin results in decreased expression of SCD mRNA
Curcumin affects the expression of SCD1 mRNA; Curcumin affects the expression of SCD1 protein

PMID:20816778 PMID:27208389

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

stearoyl-Coenzyme A desaturase 2

decreases expression

EXP

Curcumin results in decreased expression of SCD2 mRNA

NCBI chr 1:253,118,377...253,131,436
Ensembl chr 1:253,117,655...253,128,874

G

secernin 2

decreases expression

ISO

Curcumin results in decreased expression of SCRN2 mRNA

NCBI chr10:82,513,043...82,517,115
Ensembl chr10:82,507,955...82,517,114

G

succinate dehydrogenase complex flavoprotein subunit A

decreases expression

ISO

Curcumin results in decreased expression of SDHA mRNA

NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121

G

succinate dehydrogenase complex subunit C

affects binding

ISO

Curcumin binds to SDHC protein

NCBI chr13:86,077,133...86,098,025
Ensembl chr13:86,077,134...86,098,044

G

selectin E

multiple interactions
affects expression

EXP
ISO

Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELE protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELE protein]
Curcumin affects the expression of SELE protein

PMID:17960570 PMID:18565277 PMID:29244817

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

selectin L

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA]

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

selectin P

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]
Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELP protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELP protein]

PMID:18565277 PMID:29244817

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987

G

septin 7

increases expression

ISO

Curcumin results in increased expression of SEPTIN7 mRNA

NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072

G

serpin family B member 2

increases expression

ISO

Curcumin results in increased expression of SERPINB2 mRNA

NCBI chr13:24,051,933...24,065,032
Ensembl chr13:24,056,021...24,065,031

G

serpin family B member 5

increases expression
multiple interactions

ISO

[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 protein
[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein

PMID:17290611 PMID:19944674

NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400

G

serpin family E member 1

increases expression
multiple interactions

ISO

Curcumin results in increased expression of SERPINE1 mRNA
Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein]

PMID:15713895 PMID:35716765

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

serpin family E member 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]

NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202

G

serpin family H member 1

multiple interactions

EXP

Curcumin inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA]

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:163,055,630...163,062,976

G

splicing factor proline and glutamine rich

increases expression

ISO

Curcumin results in increased expression of SFPQ mRNA

NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:144,622,476...144,637,926

G

secreted frizzled-related protein 2

decreases expression
multiple interactions

EXP

Curcumin results in decreased expression of SFRP2 mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA]

NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:171,387,385...171,395,079

G

secreted frizzled-related protein 5

decreases expression

ISO

Curcumin results in decreased expression of SFRP5 mRNA

NCBI chr 1:250,956,050...250,960,512
Ensembl chr 1:250,956,050...250,960,512

G

sideroflexin 1

decreases expression

ISO

Curcumin results in decreased expression of SFXN1 mRNA

NCBI chr17:10,491,315...10,527,793
Ensembl chr17:10,491,344...10,527,456

G

sonic hedgehog signaling molecule

multiple interactions

EXP

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]

NCBI chr 4:7,687,872...7,697,025
Ensembl chr 4:7,687,846...7,697,901

G

SIM bHLH transcription factor 2

multiple interactions

EXP

Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein]

NCBI chr11:46,883,859...46,923,305
Ensembl chr11:46,883,859...46,923,305

G

sirtuin 1

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of SIRT1 mRNA
Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein]

PMID:18403477 PMID:32569592 PMID:36037877

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

sirtuin 3

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]
Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]]

PMID:26422756 PMID:28698153 PMID:28951138

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

sirtuin 6

multiple interactions

ISO

Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 protein]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542

G

sirtuin 7

decreases expression

ISO

Curcumin results in decreased expression of SIRT7

NCBI chr10:106,394,802...106,401,627
Ensembl chr10:106,394,802...106,401,498

G

src kinase associated phosphoprotein 2

decreases expression

ISO

Curcumin results in decreased expression of SKAP2 mRNA

NCBI chr 4:82,281,221...82,431,664
Ensembl chr 4:82,263,709...82,432,886

G

solute carrier family 11 member 2

increases expression

ISO

Curcumin results in increased expression of SLC11A2 mRNA

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 16 member 1

decreases expression

ISO

Curcumin results in decreased expression of SLC16A1 protein

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 18 member A2

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SLC18A2 protein]

NCBI chr 1:268,399,815...268,435,229
Ensembl chr 1:268,400,016...268,435,231

G

solute carrier family 1 member 3

multiple interactions

EXP

Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:59,482,709...59,557,808

G

solute carrier family 20 member 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC20A1 mRNA]

NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:136,880,290...136,894,249

G

solute carrier family 2 member 1

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of SLC2A1 mRNA
Curcumin results in decreased expression of SLC2A1 protein
ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SLC2A1 protein]

PMID:21397623 PMID:36640941

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 2

decreases expression
multiple interactions

ISO
EXP

Curcumin results in decreased expression of SLC2A2 mRNA
Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein]

PMID:21397623 PMID:25541178

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 3

decreases expression

ISO

Curcumin results in decreased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186

G

solute carrier family 2 member 5

decreases expression

ISO

Curcumin results in decreased expression of SLC2A5 mRNA

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:165,866,172...165,894,038

G

solute carrier family 30 member 1

increases expression

ISO

Curcumin results in increased expression of SLC30A1 mRNA

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 30, member 10

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA]

NCBI chr13:99,529,664...99,584,442
Ensembl chr13:99,529,790...99,544,213

G

solute carrier family 37 member 4

decreases expression

ISO

Curcumin results in decreased expression of SLC37A4 mRNA

NCBI chr 8:53,619,952...53,626,110
Ensembl chr 8:53,620,141...53,626,110

G

solute carrier family 3 member 2

increases expression

ISO

Curcumin results in increased expression of SLC3A2 mRNA

PMID:17198877 PMID:19183254

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 48 member 1

increases expression

ISO

Curcumin results in increased expression of SLC48A1 mRNA

NCBI chr 7:130,794,233...130,802,119
Ensembl chr 7:130,794,245...130,803,022

G

solute carrier family 6 member 3

multiple interactions

ISO

Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier family 7 member 11

multiple interactions
increases expression

EXP
ISO

Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SLC7A11 protein]
Curcumin inhibits the reaction [Firemaster BP-6 results in decreased expression of SLC7A11 protein]
Curcumin results in increased expression of SLC7A11 mRNA

PMID:17999991 PMID:19183254 PMID:34787501 PMID:39934342

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier organic anion transporter family, member 1a4

increases expression

ISO

Curcumin results in increased expression of SLCO1A2 mRNA

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

secretory leukocyte peptidase inhibitor

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA]

NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822

G

SMAD family member 2

multiple interactions

EXP

Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388

G

SMAD family member 3

multiple interactions

EXP

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]]

PMID:16959952 PMID:26648693 PMID:32718261

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 4

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]
Curcumin results in decreased expression of SMAD4 mRNA

PMID:16959952 PMID:27237783

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684

G

smoothened, frizzled class receptor

multiple interactions

EXP

[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]

NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:59,311,041...59,341,281

G

small muscle protein, X-linked

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SMPX mRNA]

NCBI chr X:41,049,354...41,107,323
Ensembl chr X:41,049,356...41,107,137

G

SMAD specific E3 ubiquitin protein ligase 1

decreases expression

ISO

Curcumin results in decreased expression of SMURF1 mRNA

NCBI chr12:14,748,717...14,840,273
Ensembl chr12:14,749,043...14,840,273

G

snail family transcriptional repressor 1

multiple interactions

ISO

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of SNAI1 protein]

PMID:25656647 PMID:34233590

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

decreases expression

ISO

Curcumin results in decreased expression of SNAI2 protein

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synuclein alpha

multiple interactions

ISO

[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein]

PMID:31187328 PMID:31820278

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

suppressor of cytokine signaling 3

decreases expression

ISO

Curcumin results in decreased expression of SOCS3 mRNA

PMID:18403477 PMID:25822711

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

suppressor of cytokine signaling 5

decreases expression

ISO

Curcumin results in decreased expression of SOCS5 protein

NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:13,234,062...13,273,883

G

superoxide dismutase 1

multiple interactions
increases expression

EXP
ISO

[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]
Curcumin results in increased expression of SOD1 protein
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of SOD1 protein]
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Atrazine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SOD1 mRNA]

PMID:19914224 PMID:25996037 PMID:30934151 PMID:31521693 PMID:35063475 More...

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

affects expression
increases expression
multiple interactions

EXP
ISO

Curcumin affects the expression of SOD2 mRNA; Curcumin affects the expression of SOD2 protein
Curcumin results in increased expression of SOD2 protein
Curcumin results in increased expression of SOD2 mRNA; Curcumin results in increased expression of SOD2 protein
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in decreased expression of and results in decreased activity of SOD2 protein]; Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of and results in decreased activity of SOD2 protein]; Curcumin analog promotes the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]
[Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein]

PMID:11543823 PMID:18299980 PMID:19914224 PMID:22316666 PMID:23452621 More...

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 2

increases expression

ISO

Curcumin results in increased expression of SOX2 mRNA; Curcumin results in increased expression of SOX2 protein

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

SRY-box transcription factor 9

multiple interactions
increases expression

ISO

[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein
Curcumin results in increased expression of SOX9 protein

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

Sp1 transcription factor

decreases expression

ISO

Curcumin results in decreased expression of SP1 protein

PMID:18347134 PMID:18593936

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

Sp3 transcription factor

decreases expression

ISO

Curcumin results in decreased expression of SP3 protein

NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:78,219,426...78,264,517

G

Sp4 transcription factor

decreases expression

ISO

Curcumin results in decreased expression of SP4 protein

NCBI chr 6:145,330,416...145,395,750
Ensembl chr 6:145,330,416...145,395,146

G

secreted protein acidic and cysteine rich

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA]

NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268

G

Spi-B transcription factor

increases expression

ISO

Curcumin results in increased expression of SPIB mRNA

NCBI chr 1:104,155,456...104,161,311
Ensembl chr 1:104,155,464...104,161,517

G

sparc/osteonectin, cwcv and kazal like domains proteoglycan 1

increases expression

ISO

Curcumin results in increased expression of SPOCK1 mRNA

NCBI chr17:6,746,892...7,227,034
Ensembl chr17:6,747,646...7,230,282

G

secreted phosphoprotein 1

multiple interactions

EXP

Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

squalene epoxidase

decreases expression
affects expression

EXP
ISO

Curcumin results in decreased expression of SQLE mRNA
Curcumin affects the expression of SQLE mRNA

NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050

G

sequestosome 1

decreases expression
multiple interactions
increases expression

ISO
EXP

Curcumin results in decreased expression of SQSTM1 protein
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SQSTM1 protein]; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [Tunicamycin results in decreased expression of SQSTM1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]
Curcumin results in increased expression of SQSTM1 protein
Curcumin inhibits the reaction [sodium arsenite results in increased expression of SQSTM1 protein]
MIR206 affects the reaction [Curcumin results in decreased expression of SQSTM1 protein]

PMID:34634291 PMID:34758851 PMID:36640941 PMID:38141737 PMID:38764151

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases expression
decreases activity
multiple interactions

ISO

Curcumin results in decreased expression of SRC protein
Curcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC protein
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC protein

PMID:16959222 PMID:33617879

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

sterol regulatory element binding transcription factor 1

affects expression
multiple interactions
decreases expression

ISO
EXP

Curcumin affects the expression of SREBF1 mRNA; Curcumin affects the expression of SREBF1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein]
Curcumin results in decreased expression of SREBF1 mRNA

PMID:27208389 PMID:37701206

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

sterol regulatory element binding transcription factor 2

affects expression
multiple interactions
decreases expression

ISO
EXP

Curcumin affects the expression of SREBF2 mRNA; Curcumin affects the expression of SREBF2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF2 protein]
Curcumin results in decreased expression of SREBF2 mRNA

PMID:27208389 PMID:37701206

NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943

G

spermidine synthase

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA]

NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:164,308,991...164,332,705

G

serine and arginine rich splicing factor 1

increases expression

ISO

Curcumin results in increased expression of SRSF1 mRNA

NCBI chr10:73,335,519...73,342,549
Ensembl chr10:73,336,422...73,342,548

G

serine and arginine rich splicing factor 2

increases expression

ISO

Curcumin results in increased expression of SRSF2 mRNA

NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,553,072...102,554,141

G

serine and arginine rich splicing factor 3

increases expression

ISO

Curcumin results in increased expression of SRSF3 mRNA

NCBI chr20:7,093,529...7,103,517
Ensembl chr20:7,093,565...7,103,516

G

serine and arginine rich splicing factor 5

decreases expression

ISO

Curcumin results in decreased expression of SRSF5 mRNA

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

serine and arginine rich splicing factor 6

increases expression

ISO

Curcumin results in increased expression of SRSF6 mRNA

NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:172,009,061...172,014,392

G

signal transducer and activator of transcription 1

multiple interactions

ISO

Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]
Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]

PMID:16959222 PMID:21811692

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions
decreases expression
increases phosphorylation
decreases phosphorylation

ISO
EXP

Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein]
[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]; Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]
Curcumin results in decreased expression of STAT3 mRNA
Curcumin results in increased phosphorylation of STAT3 protein
Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein

PMID:16959222 PMID:17666914 PMID:19383353 PMID:20816778 PMID:25822711 More...

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

signal transducer and activator of transcription 4

multiple interactions

ISO

Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein]

NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 5A

increases cleavage
decreases expression

ISO

Curcumin results in increased cleavage of STAT5A protein
Curcumin results in decreased expression of STAT5A protein

NCBI chr10:86,285,859...86,310,187
Ensembl chr10:86,285,547...86,310,184

G

signal transducer and activator of transcription 5B

increases cleavage
decreases expression

ISO

Curcumin results in increased cleavage of STAT5B protein
Curcumin results in decreased expression of STAT5B protein

NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990

G

steroid sulfatase

decreases expression

ISO

Curcumin results in decreased expression of STS mRNA

NCBI chr X:46,102,524...46,110,868
Ensembl chr X:46,102,548...46,111,104

G

STIP1 homology and U-box containing protein 1

decreases expression

ISO

Curcumin results in decreased expression of STUB1 mRNA

NCBI chr10:15,355,278...15,357,559
Ensembl chr10:15,355,279...15,357,559

G

syntaxin 3

multiple interactions

ISO

[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of STX3 mRNA

NCBI chr 1:217,940,697...218,114,865
Ensembl chr 1:217,909,169...218,110,466

G

sulfatase 1

increases expression

ISO

Curcumin results in increased expression of SULF1 mRNA; Curcumin results in increased expression of SULF1 protein

NCBI chr 5:11,145,950...11,308,622
Ensembl chr 5:11,145,950...11,308,643

G

sulfatase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA]

NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651

G

SUZ12 polycomb repressive complex 2 subunit

decreases expression

ISO

Curcumin results in decreased expression of SUZ12 mRNA

NCBI chr10:65,464,948...65,510,846
Ensembl chr10:65,464,969...65,510,846

G

small VCP interacting protein

decreases expression

ISO

Curcumin results in decreased expression of SVIP mRNA

NCBI chr 1:110,723,051...110,728,741
Ensembl chr 1:110,723,051...110,729,075

G

synaptonemal complex protein 2

increases expression

ISO

Curcumin results in increased expression of SYCP2 mRNA

NCBI chr 3:185,814,033...185,876,516
Ensembl chr 3:185,814,035...185,876,492

G

synapsin II

multiple interactions

ISO

Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYN2 protein]

NCBI chr 4:149,858,919...150,016,845
Ensembl chr 4:149,851,520...150,019,650

G

synaptic Ras GTPase activating protein 1

multiple interactions

EXP

Curcumin inhibits the reaction [sodium arsenite results in increased expression of SYNGAP1 protein]

NCBI chr20:5,028,226...5,058,519
Ensembl chr20:5,026,707...5,057,751

G

synoviolin 1

increases expression

ISO

Curcumin results in increased expression of SYVN1 mRNA; Curcumin results in increased expression of SYVN1 protein

NCBI chr 1:212,766,736...212,775,426
Ensembl chr 1:212,768,907...212,776,457

G

transcriptional adaptor 3

affects expression

EXP

Curcumin affects the expression of TADA3 mRNA

NCBI chr 4:148,065,859...148,077,347
Ensembl chr 4:148,065,877...148,077,320

G

transaldolase 1

increases expression

EXP

Curcumin results in increased expression of TALDO1 mRNA

NCBI chr 1:205,923,196...205,933,526
Ensembl chr 1:205,923,165...205,933,535

G

TBC1 domain family member 1

decreases expression

ISO

Curcumin results in decreased expression of TBC1D1 mRNA

NCBI chr14:44,289,241...44,489,246
Ensembl chr14:44,289,241...44,488,167

G

TBC1 domain family, member 8

increases expression

ISO

Curcumin results in increased expression of TBC1D8 mRNA

NCBI chr 9:49,147,109...49,257,140
Ensembl chr 9:49,147,109...49,257,118

G

TANK-binding kinase 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA]

NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357

G

T-box transcription factor T

decreases expression

ISO

Curcumin results in decreased expression of T mRNA

NCBI chr 1:54,845,674...54,859,340
Ensembl chr 1:54,845,674...54,853,583

G

transcription factor 7 like 2

multiple interactions

ISO

Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225

G

telomerase reverse transcriptase

decreases activity

ISO

Curcumin results in decreased activity of TERT protein

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:31,466,056...31,488,111

G

tet methylcytosine dioxygenase 2

increases expression

ISO

curcumin increases expression of TET2 mRNA and protein in stomach

RGD

NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186

G

transferrin

increases expression

ISO

Curcumin results in increased expression of TF mRNA

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400

G

transcription factor A, mitochondrial

multiple interactions

EXP

[Curcumin co-treated with Potassium Dichromate] results in increased expression of TFAM protein

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transcription factor EB

multiple interactions
increases localization

ISO

[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TFEB protein]
Curcumin results in increased localization of TFEB protein

PMID:34758851 PMID:38141737

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transferrin receptor

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of TFRC mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TFRC protein]

PMID:17198877 PMID:18340409 PMID:24634837 PMID:34787501

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

transforming growth factor, beta 1

multiple interactions
decreases expression
decreases activity

ISO
EXP

Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA]
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Cuprizone results in decreased expression of TGFB1]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Curcumin results in decreased expression of TGFB1 mRNA; Curcumin results in decreased expression of TGFB1 protein
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; [Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]]
Curcumin results in decreased activity of TGFB1 protein

PMID:8940178 PMID:16751071 PMID:16959952 PMID:17434272 PMID:18006644 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

transforming growth factor, beta receptor 1

multiple interactions
decreases expression

EXP

2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]
Curcumin results in decreased expression of TGFBR1 mRNA; Curcumin results in decreased expression of TGFBR1 protein

PMID:16959952 PMID:17531121 PMID:17602960

NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260

G

transforming growth factor, beta receptor 2

multiple interactions
decreases expression

EXP

Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein]
Curcumin results in decreased expression of TGFBR2 mRNA; Curcumin results in decreased expression of TGFBR2 protein

PMID:16959952 PMID:17602960

NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469

G

transglutaminase 2

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA]

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

tyrosine hydroxylase

multiple interactions

EXP
ISO

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein]
Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]

PMID:19631675 PMID:22704994 PMID:27966075 PMID:30463061 PMID:31187328

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

thrombospondin 1

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA]

NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402

G

Thy-1 cell surface antigen

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA]

NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:53,286,148...53,291,540

G

TIR domain containing adaptor molecule 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM1 mRNA]

NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,172,963...1,196,892

G

TIR domain containing adaptor molecule 2

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM2 mRNA]

NCBI chr18:41,481,057...41,498,065
Ensembl chr18:41,478,539...41,512,243

G

TIMP metallopeptidase inhibitor 1

multiple interactions
decreases expression

ISO
EXP

Curcumin inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA]
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of TIMP1 protein]
Curcumin results in decreased expression of TIMP1 protein

PMID:17996675 PMID:18200517 PMID:27363783 PMID:29421648

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
Curcumin results in decreased expression of TIMP2 protein

PMID:16934674 PMID:17996675

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

tight junction protein 1

multiple interactions

ISO

Curcumin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein]

PMID:26191140 PMID:35817260 PMID:39750044

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

toll-like receptor 1

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA]

NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,740,379...43,756,243

G

toll-like receptor 2

multiple interactions

EXP
ISO

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA]

PMID:22683883 PMID:23452621

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

multiple interactions
decreases expression

ISO
EXP

[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]
Curcumin results in decreased expression of TLR4 mRNA; Curcumin results in decreased expression of TLR4 protein

PMID:16678799 PMID:17965732 PMID:19002562 PMID:22683883 PMID:34719837 More...

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transmembrane protein 129, E3 ubiquitin ligase

increases expression

ISO

Curcumin results in increased expression of TMEM129 mRNA

NCBI chr14:81,289,852...81,295,416
Ensembl chr14:81,290,351...81,295,417

G

thiol methyltransferase 1A

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TMT1A mRNA]

NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959

G

tenascin C

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA]

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

multiple interactions
decreases expression
affects expression
increases expression

ISO
EXP

[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]
Curcumin results in decreased expression of TNF mRNA; Curcumin results in decreased expression of TNF protein
[Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; bisphenol A diglycidyl ether inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Freund's Adjuvant results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]]
Curcumin affects the expression of TNF mRNA; Curcumin affects the expression of TNF protein
Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cuprizone results in increased expression of TNF]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of TNF mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]
Curcumin results in increased expression of TNF mRNA

PMID:12086399 PMID:14555224 PMID:15489888 PMID:16023083 PMID:16219905 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 10b

multiple interactions
increases expression

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]

PMID:18226269 PMID:23452621

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082

G

TNF receptor superfamily member 12A

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFRSF12A mRNA]

NCBI chr10:13,211,670...13,213,666
Ensembl chr10:13,211,673...13,213,704

G

TNF receptor superfamily member 1A

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]

PMID:17666914 PMID:23452621

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF receptor superfamily member 1B

multiple interactions

ISO

Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:162,353,848...162,387,411

G

TNF receptor superfamily member 21

multiple interactions

ISO

[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF21 protein

NCBI chr 9:25,376,400...25,451,323
Ensembl chr 9:25,376,400...25,451,323

G

tumor necrosis factor receptor superfamily, member 22

multiple interactions

ISO

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TNFRSF10C protein

NCBI chr 1:208,269,844...208,285,823
Ensembl chr 1:208,258,836...208,289,832

G

TNF superfamily member 10

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF10 mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein]
Curcumin results in decreased expression of TNFSF10 mRNA

PMID:15713895 PMID:16101141 PMID:18226269 PMID:23452621

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 11

multiple interactions

ISO

Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein]

PMID:15129424 PMID:18719352

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

TNF superfamily member 12

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFSF12 protein]

NCBI chr10:54,902,616...54,912,628
Ensembl chr10:54,902,616...54,911,913

G

TNF superfamily member 14

multiple interactions

ISO

Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF14 mRNA]

NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,155,270...2,160,191

G

tankyrase

decreases expression

ISO

Curcumin analog results in decreased expression of TNKS mRNA

NCBI chr16:63,922,969...64,073,972
Ensembl chr16:63,928,281...64,079,282

G

troponin I3, cardiac type

multiple interactions

EXP

Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein]

NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253

G

DNA topoisomerase II alpha

multiple interactions
decreases expression

ISO

[Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA; [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA
Curcumin analog results in decreased expression of TOP2A mRNA; Curcumin results in decreased expression of TOP2A mRNA

PMID:18348204 PMID:18414057 PMID:26409325

NCBI chr10:84,441,954...84,473,093
Ensembl chr10:84,441,954...84,473,366

G

DNA topoisomerase II beta

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein]
Curcumin analog results in decreased expression of TOP2B mRNA

PMID:21332098 PMID:26409325

NCBI chr15:11,482,089...11,542,464
Ensembl chr15:11,482,089...11,542,464

G

tumor protein p53

multiple interactions
decreases expression
increases expression
increases phosphorylation
increases acetylation
affects expression
affects localization

ISO
EXP

[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]
Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein
Curcumin results in increased expression of TRP53 mRNA
[Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of TP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein]
[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [fenpropathrin results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein
Curcumin results in increased acetylation of TP53 protein
Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein
Curcumin affects the localization of TP53 protein

PMID:17041101 PMID:17332930 PMID:19020741 PMID:19227835 PMID:19944674 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tryptophan hydroxylase 1

multiple interactions

EXP

[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein]

NCBI chr 1:106,293,695...106,314,628
Ensembl chr 1:106,085,953...106,312,484

G

TNFRSF1A-associated via death domain

decreases expression

ISO

Curcumin results in decreased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

TNF receptor-associated factor 1

multiple interactions
decreases expression

ISO

Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]
Curcumin results in decreased expression of TRAF1 protein

PMID:16023083 PMID:16219905 PMID:19372569

NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:38,619,506...38,636,264

G

Tnf receptor-associated factor 2

increases expression

ISO

Curcumin results in increased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

Tnf receptor-associated factor 3

increases expression

ISO

Curcumin results in increased expression of TRAF3 mRNA

NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:136,027,157...136,128,363

G

TNF receptor associated factor 6

increases expression
multiple interactions

ISO
EXP

Curcumin results in increased expression of TRAF6 mRNA
Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TRAF6 mRNA]

PMID:16101141 PMID:34719837

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

tRNA aspartic acid methyltransferase 1

increases expression

ISO

Curcumin results in increased expression of TRDMT1

NCBI chr17:81,510,740...81,554,036
Ensembl chr17:81,521,200...81,577,639

G

triggering receptor expressed on myeloid cells 1

decreases expression

ISO

Curcumin results in decreased expression of TREM1 mRNA

NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:20,261,408...20,276,892

G

tribbles pseudokinase 3

increases expression

ISO

Curcumin results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

tripartite motif-containing 13

decreases expression

ISO

Curcumin results in decreased expression of TRIM13 mRNA

NCBI chr15:39,909,587...39,948,719
Ensembl chr15:39,902,284...39,958,892

G

tripartite motif containing 15

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIM15 mRNA]

NCBI chr20:1,703,723...1,715,465
Ensembl chr20:1,706,122...1,715,465

G

tripartite motif-containing 16

increases expression

ISO

Curcumin results in increased expression of TRIM16 mRNA

NCBI chr10:47,985,235...48,008,242
Ensembl chr10:47,958,677...48,051,136

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions

ISO

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA

NCBI chr 4:71,474,006...71,489,667
Ensembl chr 4:71,474,007...71,489,671

G

TSC complex subunit 2

decreases phosphorylation

ISO

Curcumin results in decreased phosphorylation of TSC2 protein

NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600

G

tubulin, beta 3 class III

multiple interactions
increases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA]
Curcumin results in increased expression of TUBB3 mRNA

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740

G

thioredoxin interacting protein

multiple interactions

ISO

Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of TXNIP mRNA]

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:186,781,163...186,785,731

G

thioredoxin reductase 1

increases expression
increases oxidation

ISO
EXP

Curcumin analog results in increased expression of TXNRD1 mRNA; Curcumin results in increased expression of TXNRD1 mRNA
Curcumin results in increased oxidation of TXNRD1 protein

PMID:17198877 PMID:18299980 PMID:21782934 PMID:26409325

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

thymidine phosphorylase

decreases expression
multiple interactions

ISO

Curcumin results in decreased expression of TYMP mRNA; Curcumin results in decreased expression of TYMP protein
[Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003

G

transmembrane immune signaling adaptor Tyrobp

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA]

NCBI chr 1:94,800,372...94,804,307
Ensembl chr 1:94,800,117...94,804,299

G

ubiquitin-like modifier activating enzyme 7

affects expression
multiple interactions

ISO

Curcumin affects the expression of UBA7 mRNA; Curcumin affects the expression of UBA7 protein
Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of UBA7 protein]

NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142

G

ubiquitin C

increases expression

ISO

Curcumin results in increased expression of UBC mRNA

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

ubiquitin-conjugating enzyme E2C

decreases expression

ISO

Curcumin results in decreased expression of UBE2C mRNA; Curcumin results in decreased expression of UBE2C protein

PMID:22258452 PMID:38348716

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

uncoupling protein 1

affects expression

ISO

Curcumin affects the expression of UCP1 mRNA

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

ubiquitin recognition factor in ER associated degradation 1

increases expression

ISO

Curcumin results in increased expression of UFD1 mRNA; Curcumin results in increased expression of UFD1 protein

NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions
increases glucuronidation

ISO
EXP

Curcumin results in increased expression of UGT1A1 mRNA
Curcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 protein
Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein]
UGT1A1 protein results in increased glucuronidation of Curcumin

PMID:14557274 PMID:16819192 PMID:20015472 PMID:26991801 PMID:29228771

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

increases expression

ISO

Curcumin results in increased expression of UGT1A6 mRNA

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of Curcumin

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UTP14A small subunit processome component

increases expression

ISO

Curcumin results in increased expression of UTP14A mRNA

NCBI chr X:132,317,163...132,342,524
Ensembl chr X:132,317,159...132,342,523

G

vasodilator-stimulated phosphoprotein

increases expression

ISO

Curcumin results in increased expression of VASP mRNA

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

G

vascular cell adhesion molecule 1

affects expression
multiple interactions

ISO
EXP

Curcumin affects the expression of VCAM1 mRNA
Curcumin inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]

PMID:18752423 PMID:28700904 PMID:29244817 PMID:30431687

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

versican

multiple interactions

ISO

Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA]

NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955

G

valosin-containing protein

increases expression

ISO

Curcumin results in increased expression of VCP mRNA; Curcumin results in increased expression of VCP protein

NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387

G

voltage-dependent anion channel 1

multiple interactions

ISO

Curcumin promotes the reaction [VDAC1 protein binds to VDAC1 protein]

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541

G

vitamin D receptor

multiple interactions

ISO

[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; Curcumin binds to and results in increased activity of VDR protein; Curcumin inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]; Curcumin promotes the reaction [VDR protein binds to RXRA protein]

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:130,866,745...130,916,757

G

vascular endothelial growth factor A

affects expression
decreases expression
multiple interactions

ISO
EXP

Curcumin affects the expression of VEGFA mRNA
Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
[Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA]
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]

PMID:16219905 PMID:16243823 PMID:16368150 PMID:17440100 PMID:17662242 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

von Hippel-Lindau tumor suppressor

multiple interactions

ISO

VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein]

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991

G

vimentin

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]
Curcumin inhibits the reaction [fenpropathrin results in increased expression of VIM protein]; Curcumin inhibits the reaction [Gentamicins results in increased expression of VIM mRNA]
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein]

PMID:25656647 PMID:26191140 PMID:38056816 PMID:38369055

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

vasoactive intestinal peptide

multiple interactions

ISO
EXP

Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]
Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein]

PMID:17434257 PMID:19189304

NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:44,470,462...44,478,558

G

von Willebrand factor

multiple interactions

EXP

Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein]

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

G

WASP like actin nucleation promoting factor

increases expression

ISO

Curcumin results in increased expression of WASL mRNA

NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:54,049,082...54,097,570

G

Wnt inhibitory factor 1

multiple interactions
decreases expression

EXP

Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein]
Curcumin results in decreased expression of WIF1 protein

NCBI chr 7:58,433,326...58,503,853
Ensembl chr 7:58,384,643...58,503,852

G

Wnt family member 1

increases expression
multiple interactions

EXP

Curcumin results in increased expression of WNT1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA]

NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:131,817,558...131,821,605

G

Wnt family member 3

increases expression
multiple interactions

EXP

Curcumin results in increased expression of WNT3 mRNA; Curcumin results in increased expression of WNT3 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 protein]

NCBI chr10:89,180,224...89,224,195
Ensembl chr10:89,216,801...89,224,195

G

WT1 transcription factor

decreases expression

ISO

Curcumin results in decreased expression of WT1 mRNA; Curcumin results in decreased expression of WT1 protein

PMID:18034345 PMID:19196508

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

G

WW domain containing transcription regulator 1

decreases stability
multiple interactions

ISO

Curcumin results in decreased stability of WWTR1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; Curcumin results in decreased expression of and affects the localization of WWTR1 protein; Curcumin results in increased phosphorylation of and results in decreased stability of WWTR1 protein; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in increased susceptibility to Cisplatin]

NCBI chr 2:143,801,181...143,916,941
Ensembl chr 2:143,801,181...143,991,950

G

XIAP associated factor 1

increases expression

ISO

Curcumin results in increased expression of XAF1 mRNA; Curcumin results in increased expression of XAF1 protein

NCBI chr10:57,415,935...57,428,348
Ensembl chr10:57,415,658...57,428,349

G

X-box binding protein 1

increases expression

ISO

Curcumin results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

xanthine dehydrogenase

multiple interactions

EXP

Curcumin inhibits the reaction [Indomethacin results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

EXP
ISO

Curcumin inhibits the reaction [Diethylnitrosamine results in increased expression of XIAP mRNA]
[arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein; [Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA; arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]
Curcumin analog results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP protein

PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 More...

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

exportin 1

multiple interactions

ISO

Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein]

NCBI chr14:101,434,450...101,476,705
Ensembl chr14:101,434,517...101,476,714

G

X-ray repair cross complementing 1

multiple interactions

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein]

NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613

G

X-ray repair cross complementing 4

multiple interactions

ISO

Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein]

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

G

X-ray repair cross complementing 5

decreases expression

ISO

Curcumin results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293

G

X-ray repair cross complementing 6

decreases expression

ISO

Curcumin results in decreased expression of XRCC6 mRNA

NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:115,422,662...115,443,884

G

YOD1 deubiquitinase

decreases expression

ISO

Curcumin results in decreased expression of YOD1 mRNA

NCBI chr13:44,727,319...44,733,933

G

yippee-like 3

decreases expression

ISO

Curcumin results in decreased expression of YPEL3 mRNA

NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:190,814,512...190,818,251

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreases expression

ISO

Curcumin results in decreased expression of YWHAE mRNA; Curcumin results in decreased expression of YWHAE protein

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291

G

zinc finger homeobox 3

decreases expression

ISO

Curcumin results in decreased expression of ZFHX3 mRNA

NCBI chr19:52,789,146...53,795,664
Ensembl chr19:53,551,488...53,795,664

G

zinc finger protein 287

increases expression

ISO

Curcumin results in increased expression of ZNF287 mRNA

NCBI chr10:47,896,517...47,914,860
Ensembl chr10:47,896,517...47,914,950

G

zinc finger protein 36, C3H type-like 1

decreases expression

ISO

Curcumin results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:104,663,396...104,669,815
Ensembl chr 6:104,663,399...104,687,979

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 12-lipoxygenase, 12S type

decreases activity

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX12 protein

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199

G

arachidonate 5-lipoxygenase

decreases activity

ISO
EXP

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of ALOX5 protein

PMID:2724698 PMID:7812673 PMID:25432964

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

caspase 3

multiple interactions
increases activity

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of CASP3 protein

PMID:22308955 PMID:25432964

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

hydroxysteroid 11-beta dehydrogenase 2

increases activity
multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein
[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

interleukin 6

multiple interactions
decreases expression

ISO

[2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of IL6 mRNA
2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

myeloperoxidase

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

oncostatin M receptor

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]

NCBI chr 2:57,634,517...57,688,802
Ensembl chr 2:57,634,517...57,688,561

G

prostaglandin-endoperoxide synthase 1

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of OSMR mRNA]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased cleavage of CASP8 protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

superoxide dismutase 1

multiple interactions

EXP

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [Arachidonic Acid results in increased activity of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

signal transducer and activator of transcription 3

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT3 protein]]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor necrosis factor

multiple interactions

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone inhibits the reaction [PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased stability of and affects the expression of TNF mRNA

PMID:15060681 PMID:25432964

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

ISO

2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in decreased activity of TRPC6 protein

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:14,043,877...14,149,304

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of E 3040 analog

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

affects export

ISO

ABCG2 protein affects the export of E 3040 analog

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

solute carrier family 22 member 12

multiple interactions

ISO

E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]

NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:213,274,275...213,281,380

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

ISO

ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

ADAM metallopeptidase domain 9

multiple interactions

ISO

ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]

NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646

G

alpha-fetoprotein

multiple interactions

EXP

ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aminolevulinate dehydratase

multiple interactions
decreases activity

EXP
ISO

Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]
ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]

PMID:14630126 PMID:17624921 PMID:23933410

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

arachidonate 5-lipoxygenase

decreases activity

ISO

ebselen results in decreased activity of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions
increases activity

ISO
EXP

ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
ebselen results in increased activity of CASP3 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]

PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO
EXP

ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]
ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]

PMID:18629305 PMID:23649643

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases activity
multiple interactions

EXP

ebselen results in increased activity of CAT protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]

PMID:27282967 PMID:30558456

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cytochrome c oxidase subunit 4i1

increases expression

ISO

ebselen results in increased expression of COX4I1 protein

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:65,630,432...65,636,624

G

citrate synthase

multiple interactions

ISO
EXP

ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]

PMID:27385396 PMID:32860823

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

EXP

ebselen results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649

G

epoxide hydrolase 2

multiple interactions

ISO

ebselen binds to and results in decreased activity of EPHX2 protein

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160

G

fragile X messenger ribonucleoprotein 1

multiple interactions

ISO

ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr X:152,284,857...152,322,686
Ensembl chr X:152,284,841...152,322,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

EXP

ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucokinase

multiple interactions

ISO

[ebselen co-treated with Glucose] results in increased activity of GCK protein

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glial fibrillary acidic protein

increases phosphorylation

EXP

ebselen results in increased phosphorylation of GFAP protein

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

gap junction protein, alpha 1

multiple interactions

EXP

ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689

G

glutathione peroxidase 1

multiple interactions

ISO

ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]

PMID:23795780 PMID:28383113

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

increases activity
multiple interactions

EXP

ebselen results in increased activity of GSR protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]

PMID:27282967 PMID:30558456

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 1

multiple interactions

EXP

ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528

G

glutathione S-transferase alpha 3

multiple interactions

EXP

ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]; ebselen binds to and results in decreased activity of GSTA3 protein

NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654

G

glutathione S-transferase mu 1

multiple interactions

EXP

ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

multiple interactions

EXP

ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

multiple interactions

EXP

ebselen binds to and results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heme oxygenase 1

multiple interactions

EXP

[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hematopoietic prostaglandin D synthase

increases expression

ISO

ebselen results in increased expression of HPGDS mRNA

NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:95,702,392...95,938,501

G

heat shock transcription factor 1

increases activity

ISO

ebselen results in increased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665

G

interferon gamma

multiple interactions

ISO

ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 6

multiple interactions

EXP

ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

ISO

ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

mitogen activated protein kinase 1

multiple interactions
increases activity
increases phosphorylation

ISO
EXP

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen results in increased activity of MAPK1 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein

PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity

ISO
EXP

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein
ebselen results in increased activity of MAPK3 protein

PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 9

increases phosphorylation

EXP

ebselen results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

matrix metallopeptidase 13

multiple interactions

EXP

ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

nerve growth factor

multiple interactions

ISO

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nitric oxide synthase 2

multiple interactions
decreases activity

ISO
EXP

ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
ebselen results in decreased activity of NOS2 protein

PMID:7590103 PMID:12794164

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

decreases activity

EXP

ebselen results in decreased activity of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

pancreatic and duodenal homeobox 1

multiple interactions

ISO

[ebselen co-treated with Glucose] results in increased expression of PDX1 protein

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156

G

phosphoethanolamine/phosphocholine phosphatase 1

decreases activity

ISO

ebselen results in decreased activity of PHOSPHO1 protein

NCBI chr10:81,258,810...81,266,345
Ensembl chr10:81,257,427...81,268,481

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 11 member 2

multiple interactions

ISO

ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]

NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:133,381,878...133,418,941

G

solute carrier family 2 member 2

multiple interactions

ISO
EXP

[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein
ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]

PMID:23795780 PMID:32860823

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

SMAD family member 3

multiple interactions

ISO

ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

superoxide dismutase 1

decreases response to substance
multiple interactions

ISO

ebselen results in decreased susceptibility to SOD1 protein mutant form
ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

PMID:16702190 PMID:23795780

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

tyrosine aminotransferase

multiple interactions

EXP

ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein]

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

transforming growth factor, beta 1

multiple interactions

EXP
ISO

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

PMID:11903743 PMID:16757516 PMID:21131394

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

TIMP metallopeptidase inhibitor 1

multiple interactions

EXP

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

tumor necrosis factor

multiple interactions

EXP

ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin reductase 1

multiple interactions

ISO

ebselen results in increased expression of and results in increased activity of TXNRD1 protein

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

uncoupling protein 2

multiple interactions

ISO

[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

X-box binding protein 1

increases phosphorylation

EXP

ebselen results in increased phosphorylation of XBP1 protein

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

XPA, DNA damage recognition and repair factor

multiple interactions

ISO

ebselen inhibits the reaction [Zinc binds to XPA protein]

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

multiple interactions

EXP

eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in decreased expression of ABCG2 protein]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

C-C motif chemokine ligand 2

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases activity

ISO

[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

interleukin 1 beta

multiple interactions

EXP
ISO

eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased secretion of IL1B protein]
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]

PMID:21565208 PMID:38052408

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO
EXP

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]
eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased secretion of IL6 protein]

PMID:21565208 PMID:38052408

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NFKB inhibitor alpha

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 2 member 1

multiple interactions

ISO

eupatilin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 12

multiple interactions

EXP

eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased expression of SLC2A12 protein]

NCBI chr 1:24,623,558...24,683,577
Ensembl chr 1:24,589,707...24,694,290

G

solute carrier family 2 member 9

multiple interactions

EXP

eupatilin inhibits the reaction [[potassium oxonate co-treated with Hypoxanthine] results in increased expression of SLC2A9 protein]

NCBI chr14:76,540,649...76,674,277
Ensembl chr14:76,540,571...76,674,277

G

tumor necrosis factor

multiple interactions

ISO

eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4933427D14 gene like

decreases expression

ISO

Gallic Acid results in decreased expression of KIAA0753 mRNA

NCBI chr10:57,282,433...57,331,259
Ensembl chr10:57,281,439...57,331,259

G

aminoadipate-semialdehyde dehydrogenase

increases expression

ISO

Gallic Acid results in increased expression of AASDH mRNA

NCBI chr14:31,609,488...31,636,066
Ensembl chr14:31,609,528...31,636,500

G

ATP binding cassette subfamily A member 2

decreases expression

ISO

Gallic Acid results in decreased expression of ABCA2 mRNA

NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:28,642,758...28,662,681

G

ATP binding cassette subfamily A member 5

decreases expression

ISO

Gallic Acid results in decreased expression of ABCA5 mRNA

NCBI chr10:95,739,610...95,808,633
Ensembl chr10:95,739,610...95,808,424

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO

Gallic Acid results in decreased expression of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

abhydrolase domain containing 11

decreases expression

ISO

Gallic Acid results in decreased expression of ABHD11 mRNA

NCBI chr12:27,318,739...27,322,016
Ensembl chr12:27,318,749...27,321,970

G

abl-interactor 1

decreases expression

ISO

Gallic Acid results in decreased expression of ABI1 mRNA

NCBI chr17:90,006,917...90,088,002
Ensembl chr17:90,006,925...90,087,827

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

Gallic Acid promotes the reaction [Imatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]; Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]; Imatinib Mesylate promotes the reaction [Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:35,377,391...35,480,846

G

acyl-CoA dehydrogenase family, member 10

decreases expression

ISO

Gallic Acid results in decreased expression of ACAD10 mRNA

NCBI chr12:40,561,900...40,604,378
Ensembl chr12:40,566,701...40,604,378

G

aggrecan

decreases expression

EXP

Gallic Acid results in decreased expression of ACAN mRNA

NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779

G

adhesion G protein-coupled receptor B2

increases expression

ISO

Gallic Acid results in increased expression of ADGRB2 mRNA

NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:147,611,580...147,646,726

G

adhesion G protein-coupled receptor G2

decreases expression

ISO

Gallic Acid results in decreased expression of ADGRG2 mRNA

NCBI chr X:38,106,067...38,231,286
Ensembl chr X:38,106,067...38,231,331

G

arylformamidase

decreases expression

ISO

Gallic Acid results in decreased expression of AFMID mRNA

NCBI chr10:103,544,822...103,560,408
Ensembl chr10:103,544,841...103,560,408

G

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

decreases expression

ISO

Gallic Acid results in decreased expression of AGAP3 mRNA

NCBI chr 4:11,567,191...11,617,610
Ensembl chr 4:11,567,191...11,617,285

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

A-kinase anchoring protein 13

increases expression

ISO

Gallic Acid results in increased expression of AKAP13 mRNA

NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:138,724,150...139,029,401

G

AKT serine/threonine kinase 1

decreases activity
decreases phosphorylation
multiple interactions

ISO

Gallic Acid results in decreased activity of AKT1 protein
Gallic Acid results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]]; AKT1 protein inhibits the reaction [Gallic Acid results in decreased expression of HIF1A mRNA]; AKT1 protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Gallic Acid results in decreased expression of and results in decreased phosphorylation of AKT1 protein; RHOB mutant form inhibits the reaction [Gallic Acid results in decreased phosphorylation of AKT1 protein]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]]

PMID:22387266 PMID:23153558 PMID:26530725 PMID:27087131 PMID:29061316 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aminolevulinate dehydratase

multiple interactions

EXP

Gallic Acid inhibits the reaction [Lead results in decreased activity of ALAD protein]

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

albumin

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in decreased expression of TIMP3 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of AGER protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP2 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP2 protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of NCF1 protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP1 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP2 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased phosphorylation of MAPK1 protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased phosphorylation of MAPK3 protein]; Gallic Acid inhibits the reaction [Streptozocin results in decreased expression of ALB protein]

PMID:24309158 PMID:29331653

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

ALG11, alpha-1,2-mannosyltransferase

decreases expression

ISO

Gallic Acid results in decreased expression of ALG11 mRNA

NCBI chr16:76,642,979...76,654,052
Ensembl chr16:76,646,795...76,654,040

G

alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase

decreases activity

ISO

Gallic Acid results in decreased activity of ALKBH2 protein

NCBI chr12:48,156,825...48,161,489
Ensembl chr12:48,156,827...48,161,483

G

autophagy and beclin 1 regulator 1

increases expression

ISO

Gallic Acid results in increased expression of AMBRA1 mRNA

NCBI chr 3:98,156,626...98,345,876
Ensembl chr 3:98,156,652...98,345,872

G

AMMECR1 like

decreases expression

ISO

Gallic Acid results in decreased expression of AMMECR1L mRNA

NCBI chr18:23,661,649...23,685,391
Ensembl chr18:23,661,341...23,685,649

G

antagonist of mitotic exit network 1 homolog

increases expression

ISO

Gallic Acid results in increased expression of AMN1 mRNA

NCBI chr 4:183,886,469...183,913,411
Ensembl chr 4:183,886,474...183,913,411

G

anaphase promoting complex subunit 11

increases expression

ISO

Gallic Acid results in increased expression of ANAPC11 mRNA

NCBI chr10:106,373,610...106,384,633
Ensembl chr10:106,373,634...106,384,633

G

ankyrin repeat domain containing 11

increases expression
decreases expression

ISO

Gallic Acid results in increased expression of ANKRD11 mRNA
Gallic Acid results in decreased expression of ANKRD11 mRNA

NCBI chr19:67,848,836...68,007,491
Ensembl chr19:67,848,844...68,007,491

G

ankyrin repeat domain 42

decreases expression

ISO

Gallic Acid results in decreased expression of ANKRD42 mRNA

NCBI chr 1:156,060,516...156,103,543
Ensembl chr 1:156,060,516...156,103,517

G

annexin A2

decreases expression

ISO

Gallic Acid results in decreased expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

adaptor related protein complex 1 subunit gamma 1

increases expression

ISO

Gallic Acid results in increased expression of AP1G1 mRNA

NCBI chr19:54,654,101...54,740,586
Ensembl chr19:54,620,807...54,740,586

G

adaptor related protein complex 1 subunit mu 1

increases expression

ISO

Gallic Acid results in increased expression of AP1M1 mRNA

NCBI chr16:17,620,910...17,636,431
Ensembl chr16:17,616,187...17,636,462

G

adaptor related protein complex 3 subunit delta 1

increases expression

ISO

Gallic Acid results in increased expression of AP3D1 mRNA

NCBI chr 7:9,620,909...9,656,350
Ensembl chr 7:9,620,968...9,656,342

G

apolipoprotein B

decreases secretion

ISO

Gallic Acid results in decreased secretion of APOB protein

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

amyloid beta precursor protein

multiple interactions

ISO

Gallic Acid inhibits the reaction [2,3-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]; Gallic Acid inhibits the reaction [2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]; Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 1

decreases expression

ISO

Gallic Acid results in decreased expression of AQP1 mRNA

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

actin related protein 2/3 complex, subunit 4

increases expression

ISO

Gallic Acid results in increased expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:148,077,240...148,088,428

G

ARV1 homolog, fatty acid homeostasis modulator

decreases expression

ISO

Gallic Acid results in decreased expression of ARV1 mRNA

NCBI chr19:69,589,728...69,601,547
Ensembl chr19:69,589,328...69,601,537

G

ASXL transcriptional regulator 1

decreases expression

ISO

Gallic Acid results in decreased expression of ASXL1 mRNA

NCBI chr 3:162,273,828...162,341,742
Ensembl chr 3:162,273,828...162,341,742

G

autophagy related 13

increases expression

ISO

Gallic Acid results in increased expression of ATG13 mRNA

NCBI chr 3:98,102,831...98,136,741
Ensembl chr 3:98,101,552...98,136,743

G

ATM serine/threonine kinase

decreases expression

ISO

Gallic Acid results in decreased expression of ATM mRNA

PMID:21887735 PMID:34408198

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase plasma membrane Ca2+ transporting 1

increases expression

ISO

Gallic Acid results in increased expression of ATP2B1 mRNA

NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:35,622,461...35,731,904

G

ATPase, H+ transporting V0 subunit e2

decreases expression

ISO

Gallic Acid results in decreased expression of ATP6V0E2 mRNA

NCBI chr 4:78,815,771...78,818,919
Ensembl chr 4:78,813,129...78,819,680

G

ATR serine/threonine kinase

decreases expression

ISO

Gallic Acid results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

ataxin 2

increases expression

ISO

Gallic Acid results in increased expression of ATXN2 mRNA

NCBI chr12:40,413,657...40,509,895
Ensembl chr12:40,414,904...40,510,473

G

activator of transcription and developmental regulator AUTS2

increases expression

ISO

Gallic Acid results in increased expression of AUTS2 mRNA

NCBI chr12:29,739,138...30,830,386
Ensembl chr12:29,740,523...30,830,386

G

beta-2 microglobulin

decreases expression

ISO

Gallic Acid results in decreased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:129,549,318...129,555,356

G

Beta-1,3-galactosyltransferase 6

decreases expression

ISO

Gallic Acid results in decreased expression of B3GALT6 mRNA

NCBI chr 5:171,866,428...171,868,564
Ensembl chr 5:171,864,094...171,874,789

G

beta-1,4-galactosyltransferase 4

decreases expression

ISO

Gallic Acid results in decreased expression of B4GALT4 mRNA

NCBI chr11:75,501,358...75,527,291
Ensembl chr11:75,501,366...75,527,177

G

B-cell scaffold protein with ankyrin repeats 1

increases expression

ISO

Gallic Acid results in increased expression of BANK1 mRNA

NCBI chr 2:227,203,998...227,474,008
Ensembl chr 2:227,203,998...227,474,037

G

BRCA1 associated RING domain 1

decreases expression

ISO

Gallic Acid results in decreased expression of BARD1 mRNA

NCBI chr 9:80,069,960...80,144,167
Ensembl chr 9:80,069,960...80,176,873

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

Gallic Acid results in increased expression of BAX mRNA; Gallic Acid results in increased expression of BAX protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX protein
Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BAX protein]

PMID:22245431 PMID:31925992 PMID:33002289

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

ISO
EXP

Gallic Acid inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
Gallic Acid results in decreased expression of BCL2 protein
Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Gallic Acid results in decreased expression of BCL2 protein]

PMID:19723098 PMID:21420233 PMID:22245431 PMID:31925992

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 11

decreases expression

ISO

Gallic Acid results in decreased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

BCR activator of RhoGEF and GTPase

multiple interactions

ISO

Gallic Acid promotes the reaction [Imatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]; Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]; Imatinib Mesylate promotes the reaction [Gallic Acid results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]]

NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,468,732...13,596,333

G

3-hydroxybutyrate dehydrogenase 1

increases expression

ISO

Gallic Acid results in increased expression of BDH1 mRNA

NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636

G

brain-derived neurotrophic factor

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]
Gallic Acid results in increased expression of BDNF mRNA

PMID:29061316 PMID:34408198

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

Gallic Acid results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911

G

basic helix-loop-helix ARNT like 1

multiple interactions
increases expression

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 mRNA]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of BMAL1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX4 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]
Gallic Acid results in increased expression of BMAL1 mRNA

PMID:29061316 PMID:34408198

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739

G

BMP-2 inducible kinase

increases expression

ISO

Gallic Acid results in increased expression of BMP2K mRNA

NCBI chr14:12,785,169...12,882,676
Ensembl chr14:12,785,169...12,882,657

G

BCL2 interacting protein 3

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BNIP3 protein]]

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BRCA1/BRCA2-containing complex subunit 3

decreases expression

ISO

Gallic Acid results in decreased expression of BRCC3 mRNA

NCBI chr 9:2,073,927...2,076,469
Ensembl chr 9:2,073,184...2,084,185

G

BTB domain containing 3

decreases expression

ISO

Gallic Acid results in decreased expression of BTBD3 mRNA

NCBI chr 3:146,044,053...146,074,189
Ensembl chr 3:146,044,096...146,074,635

G

similar to human chromosome 21 open reading frame 58

decreases expression

ISO

Gallic Acid results in decreased expression of C21ORF58 mRNA

NCBI chr20:12,165,853...12,187,271
Ensembl chr20:12,174,928...12,186,503

G

similar to human chromosome 2 open reading frame 88

increases expression

ISO

Gallic Acid results in increased expression of AKAP19 mRNA

NCBI chr 9:56,037,234...56,076,793
Ensembl chr 9:56,031,114...56,131,839

G

calcium channel flower domain containing 1

decreases expression

ISO

Gallic Acid results in decreased expression of CACFD1 mRNA

NCBI chr 3:30,733,958...30,750,237
Ensembl chr 3:30,736,637...30,744,764

G

calcium binding and coiled-coil domain 2

increases expression

ISO

Gallic Acid results in increased expression of CALCOCO2 mRNA

NCBI chr10:81,552,084...81,568,266

G

calcium/calmodulin-dependent protein kinase II gamma

increases expression

ISO

Gallic Acid results in increased expression of CAMK2G mRNA

NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310

G

calmodulin regulated spectrin-associated protein family, member 2

increases expression

ISO

Gallic Acid results in increased expression of CAMSAP2 mRNA

NCBI chr13:50,274,950...50,354,298
Ensembl chr13:50,274,950...50,354,298

G

calpain 1

decreases expression

ISO

Gallic Acid results in decreased expression of CAPN1 mRNA

NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445

G

calpain, small subunit 1

increases expression

ISO

Gallic Acid results in increased expression of CAPNS1 mRNA

NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:94,572,083...94,583,368

G

calcium/calmodulin dependent serine protein kinase

decreases expression

ISO

Gallic Acid results in decreased expression of CASK mRNA

NCBI chr X:11,572,328...11,915,831
Ensembl chr X:11,572,636...11,911,948

G

caspase 3

increases expression
multiple interactions
decreases expression
increases cleavage
increases activity

ISO
EXP

Gallic Acid results in increased expression of CASP3 mRNA; Gallic Acid results in increased expression of CASP3 protein
Gallic Acid inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]
Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CASP3 protein]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased activity of CASP3 protein]
Gallic Acid results in decreased expression of CASP3 mRNA
Gallic Acid results in increased cleavage of CASP3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Gallic Acid results in increased cleavage of CASP3 protein]; [Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of CASP3 protein
Gallic Acid results in increased activity of CASP3 protein

PMID:22245431 PMID:24726691 PMID:27060209 PMID:29205955 PMID:29981346 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases activity
decreases expression

ISO

Gallic Acid results in increased activity of CASP7 protein
Gallic Acid results in decreased expression of CASP7 mRNA

PMID:24726691 PMID:34408198

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 8

increases expression

ISO

Gallic Acid results in increased expression of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions
increases cleavage

ISO

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Gallic Acid results in increased cleavage of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

calpastatin

decreases expression

ISO

Gallic Acid results in decreased expression of CAST mRNA

NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180

G

catalase

multiple interactions
increases activity

EXP
ISO

Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Cadmium results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Gallic Acid inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of CAT protein]
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in decreased activity of CAT protein]
Gallic Acid results in increased activity of CAT protein

PMID:19146839 PMID:26341651 PMID:29205955 PMID:29331653 PMID:31925992 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cystathionine beta synthase

decreases expression

ISO

Gallic Acid results in decreased expression of CBS mRNA

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066

G

coiled-coil domain containing 117

increases expression

ISO

Gallic Acid results in increased expression of CCDC117 mRNA

NCBI chr14:84,614,282...84,623,648
Ensembl chr14:84,614,283...84,624,087

G

cholecystokinin A receptor

multiple interactions

EXP

Gallic Acid inhibits the reaction [8-sulfocholecystokinin octapeptide results in increased activity of CCKAR protein]

NCBI chr14:61,505,270...61,513,618
Ensembl chr14:61,505,270...61,513,618

G

C-C motif chemokine ligand 2

multiple interactions

EXP
ISO

Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of CCL2 mRNA]
Gallic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:23892052 PMID:31306686

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin E1

decreases expression

ISO

Gallic Acid results in decreased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

centriole, cilia and spindle-associated protein

decreases expression

ISO

Gallic Acid results in decreased expression of CCSAP mRNA

NCBI chr19:68,722,417...68,740,908

G

CD59b molecule

decreases expression

ISO

Gallic Acid results in decreased expression of CD59 mRNA

NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310

G

cell division cycle 42

decreases expression

ISO

Gallic Acid results in decreased expression of CDC42 protein

NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627

G

cyclin-dependent kinase 7

decreases expression

ISO

Gallic Acid results in decreased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

Gallic Acid results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

Gallic Acid results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cyclin-dependent kinase inhibitor 3

decreases expression

ISO

Gallic Acid results in decreased expression of CDKN3 mRNA

NCBI chr15:22,502,299...22,513,725
Ensembl chr15:22,502,382...22,513,722

G

CCAAT/enhancer binding protein beta

decreases expression

ISO

Gallic Acid results in decreased expression of CEBPB protein

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

centrosomal protein 162

decreases expression

ISO

Gallic Acid results in decreased expression of CEP162 mRNA

NCBI chr 8:97,029,677...97,088,243
Ensembl chr 8:97,029,677...97,088,207

G

centrosomal protein 57-like 1

decreases expression

ISO

Gallic Acid results in decreased expression of CEP57L1 mRNA

NCBI chr20:46,820,350...46,876,911
Ensembl chr20:46,820,353...46,876,926

G

ceramide synthase 6

decreases expression

ISO

Gallic Acid results in decreased expression of CERS6 mRNA

NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:74,038,851...74,287,544

G

carbohydrate sulfotransferase 8

decreases expression

ISO

Gallic Acid results in decreased expression of CHST8 mRNA

NCBI chr 1:96,431,144...96,572,880
Ensembl chr 1:96,431,145...96,572,880

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
decreases activity

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]
Gallic Acid results in decreased activity of CHUK protein

PMID:21420233 PMID:22387266

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

CBY1 interacting BAR domain containing 1

decreases expression

ISO

Gallic Acid results in decreased expression of CIBAR1 mRNA

NCBI chr 5:30,411,325...30,429,770
Ensembl chr 5:30,410,511...30,429,893

G

cold inducible RNA binding protein

increases expression

ISO

Gallic Acid results in increased expression of CIRBP mRNA

NCBI chr 7:10,184,515...10,189,623

G

creatine kinase B

multiple interactions

EXP

Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478

G

creatine kinase, M-type

multiple interactions

EXP

Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of [CKM protein binds to CKB protein]]

NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719

G

CAP-GLY domain containing linker protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of CLIP1 mRNA

NCBI chr12:38,571,533...38,678,779
Ensembl chr12:38,571,834...38,678,779

G

CLN5, intracellular trafficking protein

decreases expression

ISO

Gallic Acid results in decreased expression of CLN5 mRNA

NCBI chr15:86,308,286...86,321,679
Ensembl chr 2:67,620,667...67,622,952
Ensembl chr15:67,620,667...67,622,952

G

clock circadian regulator

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK mRNA]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CLOCK protein]

NCBI chr14:32,262,747...32,346,872
Ensembl chr14:32,262,750...32,346,872

G

CCR4-NOT transcription complex, subunit 6-like

decreases expression

ISO

Gallic Acid results in decreased expression of CNOT6L mRNA

NCBI chr14:13,714,475...13,806,481
Ensembl chr14:13,714,475...13,806,481

G

CCR4-NOT transcription complex, subunit 7

increases expression

ISO

Gallic Acid results in increased expression of CNOT7 mRNA

NCBI chr16:58,478,882...58,498,046
Ensembl chr16:58,478,900...58,498,046

G

cochlin

increases expression

ISO

Gallic Acid results in increased expression of COCH mRNA

NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:74,766,419...74,780,502

G

collagen type II alpha 1 chain

decreases expression

EXP

Gallic Acid results in decreased expression of COL2A1 mRNA

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

COMM domain containing 9

increases expression

ISO

Gallic Acid results in increased expression of COMMD9 mRNA

NCBI chr 3:108,630,903...108,645,427
Ensembl chr 3:108,630,980...108,666,091

G

COP9 signalosome subunit 7B

decreases expression

ISO

Gallic Acid results in decreased expression of COPS7B mRNA

NCBI chr 9:94,686,314...94,711,903
Ensembl chr 9:94,686,314...94,711,903

G

coenzyme Q8B

increases expression

ISO

Gallic Acid results in increased expression of COQ8B mRNA

NCBI chr 1:91,653,241...91,676,822
Ensembl chr 1:91,654,225...91,676,819

G

cytochrome c oxidase subunit 6C

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX6C mRNA]]

NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:69,014,417...69,027,166

G

cleavage and polyadenylation specific factor 7

increases expression

ISO

Gallic Acid results in increased expression of CPSF7 mRNA

NCBI chr 1:216,592,745...216,616,860
Ensembl chr 1:216,592,463...216,616,855

G

cAMP responsive element binding protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]; [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cAMP responsive element modulator

decreases expression
increases expression

ISO

Gallic Acid results in decreased expression of CREM mRNA
Gallic Acid results in increased expression of CREM mRNA

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160

G

cryptochrome circadian regulator 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY1 mRNA]

NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:20,417,107...20,481,822

G

cryptochrome circadian regulator 2

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of CRY2 mRNA]

NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:98,830,483...98,860,447

G

crystallin beta-gamma domain containing 2

increases expression

ISO

Gallic Acid results in increased expression of CRYBG2 mRNA

NCBI chr 5:151,570,154...151,602,164
Ensembl chr 5:151,570,540...151,602,163

G

citrate synthase

increases activity

ISO

Gallic Acid results in increased activity of CS protein

NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:1,342,942...1,375,938

G

CTD small phosphatase like 2

increases expression

ISO

Gallic Acid results in increased expression of CTDSPL2 mRNA

NCBI chr 3:129,365,709...129,424,232
Ensembl chr 3:129,368,938...129,424,232

G

catenin delta 1

decreases expression

ISO

Gallic Acid results in decreased expression of CTNND1 mRNA

NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:90,090,564...90,141,189

G

cathepsin B

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in decreased expression of CTSB protein]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in decreased expression of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin G

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in decreased expression of CTSG protein]

NCBI chr15:33,901,230...33,907,596
Ensembl chr15:33,901,754...33,907,596

G

C-X-C motif chemokine receptor 4

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

CXXC finger protein 5

decreases expression

ISO

Gallic Acid results in decreased expression of CXXC5 mRNA

NCBI chr18:27,701,650...27,732,633
Ensembl chr18:27,701,188...27,732,635

G

cytochrome b5 reductase 2

increases expression

ISO

Gallic Acid results in increased expression of CYB5R2 mRNA

NCBI chr 1:171,062,083...171,076,183
Ensembl chr 1:171,067,614...171,075,904

G

cytochrome c, somatic

affects localization
increases expression

ISO

Gallic Acid affects the localization of CYCS protein
Gallic Acid results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

CYLD lysine 63 deubiquitinase

decreases expression

ISO

Gallic Acid results in decreased expression of CYLD mRNA

NCBI chr19:34,487,491...34,547,311
Ensembl chr19:34,488,583...34,547,118

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

EXP

Gallic Acid results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 20, subfamily a, polypeptide 1

decreases expression

ISO

Gallic Acid results in decreased expression of CYP20A1 mRNA

NCBI chr 9:69,249,841...69,299,146
Ensembl chr 9:69,249,844...69,299,291

G

death associated protein kinase 1

decreases expression

ISO

Gallic Acid results in decreased expression of DAPK1 mRNA

NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,935,625...4,096,581

G

drebrin 1

decreases expression

ISO

Gallic Acid results in decreased expression of DBN1 mRNA

NCBI chr17:9,155,729...9,170,121
Ensembl chr17:9,155,787...9,170,122

G

DDB1 and CUL4 associated factor 4

decreases expression

ISO

Gallic Acid results in decreased expression of DCAF4 mRNA

NCBI chr 6:108,885,970...108,912,116
Ensembl chr 6:108,885,932...108,912,110

G

DEAD-box helicase 1

increases expression

ISO

Gallic Acid results in increased expression of DDX1 mRNA

NCBI chr 6:41,725,365...41,756,236
Ensembl chr 6:41,725,367...41,758,302

G

DEAD-box helicase 47

decreases expression

ISO

Gallic Acid results in decreased expression of DDX47 mRNA

NCBI chr 4:169,577,013...169,589,473
Ensembl chr 4:169,577,003...169,590,474

G

DExD-box helicase 50

decreases expression

ISO

Gallic Acid results in decreased expression of DDX50 mRNA

NCBI chr20:31,104,354...31,133,652
Ensembl chr20:31,104,354...31,133,652

G

DEP domain containing 5, GATOR1 subcomplex subunit

increases expression
decreases expression

ISO

Gallic Acid results in increased expression of DEPDC5 mRNA
Gallic Acid results in decreased expression of DEPDC5 mRNA

NCBI chr14:81,956,777...82,087,392
Ensembl chr14:81,956,777...82,087,246

G

DGCR8 microprocessor complex subunit

decreases expression

ISO

Gallic Acid results in decreased expression of DGCR8 mRNA

NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551

G

D-glutamate cyclase

decreases expression

ISO

Gallic Acid results in decreased expression of DGLUCY mRNA

NCBI chr 6:125,785,075...125,860,496
Ensembl chr 6:125,785,087...125,860,496

G

24-dehydrocholesterol reductase

decreases expression

ISO

Gallic Acid results in decreased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936

G

diaphanous-related formin 1

increases expression

ISO

Gallic Acid results in increased expression of DIAPH1 mRNA

NCBI chr18:29,920,889...30,020,280
Ensembl chr18:29,920,889...30,020,280

G

diaphanous-related formin 2

decreases expression

ISO

Gallic Acid results in decreased expression of DIAPH2 mRNA

NCBI chr X:96,700,535...97,528,080
Ensembl chr X:96,700,726...97,528,080

G

disco-interacting protein 2 homolog C

decreases expression

ISO

Gallic Acid results in decreased expression of DIP2C mRNA

NCBI chr17:65,338,711...65,724,111
Ensembl chr17:65,338,711...65,723,344

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

ISO

Gallic Acid results in decreased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

dynamin 1

multiple interactions
decreases expression

ISO

BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]
Gallic Acid results in decreased expression of DNM1 mRNA

PMID:29061316 PMID:34408198

NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:36,002,064...36,046,289

G

dynamin 1-like

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

dynamin 3

increases expression

ISO

Gallic Acid results in increased expression of DNM3 mRNA

NCBI chr13:76,892,381...77,371,346
Ensembl chr13:76,892,171...77,371,350

G

dedicator of cytokinesis 7

decreases expression

ISO

Gallic Acid results in decreased expression of DOCK7 mRNA

NCBI chr 5:118,714,863...118,898,362
Ensembl chr 5:118,714,863...118,898,335

G

dipeptidyl peptidase 9

increases expression

ISO

Gallic Acid results in increased expression of DPP9 mRNA

NCBI chr 9:1,098,505...1,133,500
Ensembl chr 9:1,095,929...1,177,715

G

dystonin

decreases expression

ISO

Gallic Acid results in decreased expression of DST mRNA

NCBI chr 9:43,631,716...44,025,535
Ensembl chr 9:43,631,517...44,025,533

G

E2F transcription factor 7

decreases expression

ISO

Gallic Acid results in decreased expression of E2F7 mRNA

NCBI chr 7:48,036,881...48,079,055
Ensembl chr 7:48,037,749...48,079,055

G

EBP like

decreases expression

ISO

Gallic Acid results in decreased expression of EBPL mRNA

NCBI chr15:39,684,140...39,707,537
Ensembl chr15:39,684,140...39,707,537

G

eukaryotic translation elongation factor 1 delta

decreases expression
increases expression

ISO

Gallic Acid results in decreased expression of EEF1D mRNA
Gallic Acid results in increased expression of EEF1D mRNA

NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:109,462,646...109,489,531

G

epidermal growth factor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased acetylation of and results in increased expression of EP300 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased activity of SRC protein]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of and results in increased secretion of MMP9 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]; SRC protein modified form affects the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]]

PMID:27087131 PMID:27634460

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; SRC protein modified form affects the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]

PMID:27087131 PMID:27634460

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

EARP complex and GARP complex interacting protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of EIPR1 mRNA

NCBI chr 6:51,116,827...51,230,453
Ensembl chr 6:51,116,747...51,230,452

G

endosome-lysosome associated apoptosis and autophagy regulator family member 2

decreases expression

ISO

Gallic Acid results in decreased expression of ELAPOR2 mRNA

NCBI chr 4:25,565,298...25,760,684
Ensembl chr 4:25,568,122...25,760,684

G

ELMO domain containing 3

decreases expression

ISO

Gallic Acid results in decreased expression of ELMOD3 mRNA

NCBI chr 4:106,172,819...106,211,286
Ensembl chr 4:106,172,828...106,211,229

G

EMSY transcriptional repressor, BRCA2 interacting

decreases expression

ISO

Gallic Acid results in decreased expression of EMSY mRNA

NCBI chr 1:162,295,167...162,364,742
Ensembl chr 1:162,295,169...162,364,707

G

enolase 2

decreases expression

ISO

Gallic Acid results in decreased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

enolase-phosphatase 1

increases expression

ISO

Gallic Acid results in increased expression of ENOPH1 mRNA

NCBI chr14:9,835,626...9,862,051
Ensembl chr14:9,835,627...9,873,668

G

E1A binding protein p300

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased acetylation of and results in increased expression of EP300 protein]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574

G

erythrocyte membrane protein band 4.1

increases expression
decreases expression

ISO

Gallic Acid results in increased expression of EPB41 mRNA
Gallic Acid results in decreased expression of EPB41 mRNA

NCBI chr 5:149,394,080...149,548,178
Ensembl chr 5:149,394,096...149,543,540

G

ERGIC and golgi 3

increases expression

ISO

Gallic Acid results in increased expression of ERGIC3 mRNA

NCBI chr 3:164,985,108...164,994,897
Ensembl chr 3:164,984,853...164,994,897

G

family with sequence similarity 110, member A

increases expression

ISO

Gallic Acid results in increased expression of FAM110A mRNA

NCBI chr 3:160,934,815...160,945,405
Ensembl chr 3:160,931,777...160,949,897

G

family with sequence similarity 13, member C

decreases expression

ISO

Gallic Acid results in decreased expression of FAM13C mRNA

NCBI chr20:18,064,706...18,186,888
Ensembl chr20:18,064,706...18,286,674

G

FA complementation group M

increases expression

ISO

Gallic Acid results in increased expression of FANCM mRNA

NCBI chr 6:88,862,898...88,916,701
Ensembl chr 6:88,863,306...88,921,652

G

Fas ligand

increases expression

ISO

Gallic Acid results in increased expression of FASLG protein

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

F-box and WD repeat domain containing 11

decreases expression

ISO

Gallic Acid results in decreased expression of FBXW11 mRNA

NCBI chr10:17,737,181...17,834,834
Ensembl chr10:17,720,444...17,834,834

G

fission, mitochondrial 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of FIS1 protein]]

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:25,345,239...25,349,335

G

FKBP prolyl isomerase 10

increases expression

ISO

Gallic Acid results in increased expression of FKBP10 mRNA

NCBI chr10:85,845,801...85,858,361
Ensembl chr10:85,844,703...85,858,355

G

fukutin related protein

increases expression

ISO

Gallic Acid results in increased expression of FKRP mRNA

NCBI chr 1:86,607,769...86,615,045
Ensembl chr 1:86,595,180...86,627,257

G

fibronectin leucine rich transmembrane protein 3

increases expression

ISO

Gallic Acid results in increased expression of FLRT3 mRNA

NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:148,439,354...148,461,650

G

fibronectin 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

formin binding protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of FNBP1 mRNA

NCBI chr 3:34,706,814...34,826,770
Ensembl chr 3:34,706,814...34,822,117

G

folate receptor alpha

increases expression

ISO

Gallic Acid results in increased expression of FOLR1 mRNA

NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:165,631,462...165,642,669

G

forkhead box O3

multiple interactions

ISO

Gallic Acid inhibits the reaction [Doxorubicin results in decreased phosphorylation of FOXO3 protein]

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

follicle stimulating hormone subunit beta

multiple interactions

EXP
ISO

Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of FSHB protein]
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of FSHB protein]

PMID:34723416 PMID:35196152

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP

Gallic Acid inhibits the reaction [Zearalenone results in decreased activity of G6PD protein]

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

GA binding protein transcription factor subunit alpha

multiple interactions

ISO

Gallic Acid affects the localization of and results in increased activity of GABPA protein; pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of GABPA protein]; SB 203580 inhibits the reaction [Gallic Acid results in increased expression of GABPA protein]

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:37,375,084...37,404,059

G

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

decreases expression

ISO

Gallic Acid results in decreased expression of GART mRNA

NCBI chr11:44,351,841...44,377,086
Ensembl chr11:44,351,851...44,377,086

G

globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)

increases expression

ISO

Gallic Acid results in increased expression of GBGT1 mRNA

NCBI chr 3:32,219,370...32,227,737

G

gem (nuclear organelle) associated protein 7

decreases expression

ISO

Gallic Acid results in decreased expression of GEMIN7 mRNA

NCBI chr 1:88,343,032...88,352,473
Ensembl chr 1:88,342,361...88,354,571

G

Gfo/Idh/MocA-like oxidoreductase domain containing 2

decreases expression

ISO

Gallic Acid results in decreased expression of GFOD2 mRNA

NCBI chr19:50,508,626...50,556,945
Ensembl chr19:50,513,709...50,557,132

G

golgi associated, gamma adaptin ear containing, ARF binding protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of GGA1 mRNA

NCBI chr 7:112,316,530...112,332,249
Ensembl chr 7:112,315,449...112,332,249

G

GRB10 interacting GYF protein 2

decreases expression

ISO

Gallic Acid results in decreased expression of GIGYF2 mRNA

NCBI chr 9:95,449,143...95,574,927
Ensembl chr 9:95,449,167...95,574,927

G

GIPC PDZ domain containing family, member 3

decreases expression

ISO

Gallic Acid results in decreased expression of GIPC3 mRNA

NCBI chr 7:9,026,905...9,034,005
Ensembl chr 7:9,026,905...9,034,795

G

gap junction protein, gamma 1

increases expression

ISO

Gallic Acid results in increased expression of GJC1 mRNA

NCBI chr10:88,262,840...88,285,646
Ensembl chr10:88,249,489...88,285,853

G

GLI family zinc finger 2

decreases expression

ISO

Gallic Acid results in decreased expression of GLI2 mRNA

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:32,499,678...32,716,418

G

G protein subunit alpha L

increases expression

ISO

Gallic Acid results in increased expression of GNAL mRNA

NCBI chr18:62,892,257...63,032,510
Ensembl chr18:62,892,226...63,043,129

G

G protein subunit beta 3

decreases expression

ISO

Gallic Acid results in decreased expression of GNB3 mRNA

NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:159,325,742...159,331,445

G

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

decreases expression

ISO

Gallic Acid results in decreased expression of GNE mRNA

NCBI chr 5:63,062,953...63,103,320
Ensembl chr 5:63,062,850...63,103,251

G

golgin A3

increases expression

ISO

Gallic Acid results in increased expression of GOLGA3 mRNA

NCBI chr12:52,112,129...52,160,311
Ensembl chr12:52,114,590...52,160,226

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [Paraquat results in increased expression of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

ISO
EXP

Gallic Acid inhibits the reaction [Ethanol results in increased activity of GPT protein]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased activity of GPT protein]]
[Gallic Acid co-treated with Dietary Fats co-treated with Dust] affects the expression of GPT protein; Gallic Acid inhibits the reaction [Dust results in increased expression of GPT protein]; Gallic Acid inhibits the reaction [Paraquat results in increased expression of GPT protein]

PMID:30853489 PMID:32734364 PMID:33953864 PMID:34745924

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

growth factor receptor bound protein 2

decreases expression

ISO

Gallic Acid results in decreased expression of GRB2 protein

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138

G

glutathione-disulfide reductase

multiple interactions

EXP

Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of GSR protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of GSR protein]; Gallic Acid inhibits the reaction [Isoproterenol results in decreased expression of GSR protein]

PMID:19146839 PMID:26341651 PMID:31925992

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

GTP binding protein 10

decreases expression

ISO

Gallic Acid results in decreased expression of GTPBP10 mRNA

NCBI chr 4:29,431,683...29,449,201
Ensembl chr 4:29,431,692...29,449,212

G

glycogen synthase 1

decreases expression

ISO

Gallic Acid results in decreased expression of GYS1 mRNA

NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:105,051,961...105,072,419

G

H2B clustered histone 18

decreases expression

ISO

Gallic Acid results in decreased expression of H2BC18 mRNA

NCBI chr 2:186,527,197...186,531,634

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression

ISO

Gallic Acid results in increased expression of HADHB mRNA

NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835

G

HMG-box transcription factor 1

decreases expression

ISO

Gallic Acid results in decreased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

ISO

AKT1 protein inhibits the reaction [Gallic Acid results in decreased expression of HIF1A mRNA]; HIF1A protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]
Gallic Acid results in decreased expression of HIF1A mRNA; Gallic Acid results in decreased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

heat shock protein nuclear import factor hikeshi

increases expression

ISO

Gallic Acid results in increased expression of HIKESHI mRNA

NCBI chr 1:153,237,948...153,261,856
Ensembl chr 1:153,237,948...153,261,911

G

holocarboxylase synthetase

decreases activity

ISO

Gallic Acid results in decreased activity of HLCS protein

NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082

G

hydroxymethylbilane synthase

decreases expression

ISO

Gallic Acid results in decreased expression of HMBS mRNA

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802

G

high mobility group box 1

multiple interactions
increases expression

ISO

Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]
Gallic Acid results in increased expression of HMGB1 mRNA

PMID:30853489 PMID:34408198

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

multiple interactions

EXP
ISO

[Gallic Acid co-treated with Dust] results in increased expression of HMOX1 mRNA; Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of HMOX1 mRNA]; Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of and results in increased activity of HMOX1 protein]
[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of HMOX1 protein]

PMID:23892052 PMID:29061316 PMID:33953864 PMID:34745924

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heme oxygenase 2

increases expression

ISO

Gallic Acid results in increased expression of HMOX2 mRNA

NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800

G

homeo box C10

decreases expression

ISO

Gallic Acid results in decreased expression of HOXC10 mRNA

NCBI chr 7:135,982,222...135,987,442
Ensembl chr 7:135,982,065...135,986,712

G

histamine receptor H 1

decreases expression

ISO

Gallic Acid results in decreased expression of HRH1 mRNA

NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

ISO

Gallic Acid results in decreased expression of HSD17B4 mRNA

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

heat shock protein 90 alpha family class A member 1

decreases expression

ISO

Gallic Acid results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:135,523,616...135,528,499

G

heat shock protein family A (Hsp70) member 8

decreases expression

ISO

Gallic Acid results in decreased expression of HSPA8 mRNA

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372

G

huntingtin

decreases expression

ISO

Gallic Acid results in decreased expression of HTT mRNA

NCBI chr14:80,070,456...80,219,668
Ensembl chr14:80,070,456...80,219,668

G

hyccin PI4KA lipid kinase complex subunit 1

decreases expression

ISO

Gallic Acid results in decreased expression of HYCC1 mRNA

NCBI chr 4:12,024,692...12,131,504
Ensembl chr 4:12,024,739...12,131,501

G

inhibitor of Bruton tyrosine kinase

increases expression

ISO

Gallic Acid results in increased expression of IBTK mRNA

NCBI chr 8:95,505,630...95,579,435
Ensembl chr 8:95,505,630...95,578,301

G

intercellular adhesion molecule 1

multiple interactions

EXP

Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inducible T-cell co-stimulator ligand

increases expression

ISO

Gallic Acid results in increased expression of ICOSLG mRNA

NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,078...10,610,365

G

interferon gamma

multiple interactions

ISO

[Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; Gallic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Gallic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interferon gamma receptor 1

decreases expression

ISO

Gallic Acid results in decreased expression of IFNGR1 mRNA

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:16,152,879...16,171,437

G

interferon-related developmental regulator 2

increases expression

ISO

Gallic Acid results in increased expression of IFRD2 mRNA

NCBI chr 8:117,139,612...117,144,834
Ensembl chr 8:117,139,550...117,144,836

G

intraflagellar transport 27

increases expression

ISO

Gallic Acid results in increased expression of IFT27 mRNA

NCBI chr 7:111,619,145...111,635,129
Ensembl chr 7:111,619,077...111,634,936

G

insulin-like growth factor 1 receptor

increases expression

ISO

Gallic Acid results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

IKAROS family zinc finger 2

increases expression

ISO

Gallic Acid results in increased expression of IKZF2 mRNA

NCBI chr 9:78,495,670...78,640,896
Ensembl chr 9:78,492,275...78,640,463

G

interleukin 17 receptor C

decreases expression

ISO

Gallic Acid results in decreased expression of IL17RC mRNA

NCBI chr 4:148,174,573...148,187,071
Ensembl chr 4:148,174,578...148,187,068

G

interleukin 1 beta

multiple interactions

EXP
ISO

Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Gallic Acid inhibits the reaction [cobaltous chloride results in increased expression of IL1B protein]; Gallic Acid inhibits the reaction [Glucose results in increased secretion of IL1B protein]; Gallic Acid inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [Paraquat results in increased expression of IL1B protein]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL1B protein]
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL1B protein]
[Gallic Acid co-treated with Butyric Acid co-treated with verbascose] affects the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]; Gallic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased secretion of IL1B protein]

PMID:23892052 PMID:26341651 PMID:29981346 PMID:31362009 PMID:32734364 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

decreases expression

ISO

Gallic Acid results in decreased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 6

multiple interactions

ISO
EXP

Gallic Acid inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
Gallic Acid inhibits the reaction [Acrylamide results in increased secretion of IL6 protein]
Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of IL6 mRNA]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Gallic Acid inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Gallic Acid inhibits the reaction [Quinolinic Acid results in increased expression of IL6 protein]

PMID:21420233 PMID:26341651 PMID:29981346 PMID:34745924 PMID:37037409

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inosine monophosphate dehydrogenase 1

decreases expression

ISO

Gallic Acid results in decreased expression of IMPDH1 mRNA

NCBI chr 4:58,767,230...58,782,825
Ensembl chr 4:58,767,230...58,783,124

G

insulin 1

increases secretion

EXP

Gallic Acid results in increased secretion of INS1 protein

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

integrator complex subunit 14

decreases expression

ISO

Gallic Acid results in decreased expression of INTS14 mRNA

NCBI chr 8:74,370,687...74,398,153
Ensembl chr 8:74,371,015...74,396,209

G

inositol hexakisphosphate kinase 2

increases expression

ISO

Gallic Acid results in increased expression of IP6K2 mRNA

NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667

G

IST1 factor associated with ESCRT-III

increases expression

ISO

Gallic Acid results in increased expression of IST1 mRNA

NCBI chr19:54,558,353...54,580,551
Ensembl chr19:54,558,353...54,580,491

G

integrin subunit alpha M

multiple interactions

ISO

Gallic Acid inhibits the reaction [Acrylamide results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit alpha V

decreases expression

ISO

Gallic Acid results in decreased expression of ITGAV protein

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511

G

integrin subunit beta 3

decreases expression
multiple interactions

ISO

Gallic Acid results in decreased expression of ITGB3 protein
Gallic Acid affects the reaction [MIR1247 affects the expression of ITGB3 protein]

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800

G

integral membrane protein 2C

decreases expression

ISO

Gallic Acid results in decreased expression of ITM2C mRNA

NCBI chr 9:93,993,922...94,007,737
Ensembl chr 9:93,993,895...94,007,704

G

jumonji domain containing 4

increases expression

ISO

Gallic Acid results in increased expression of JMJD4 mRNA

NCBI chr10:44,734,047...44,742,296
Ensembl chr10:44,734,070...44,742,296

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

PMID:27087131 PMID:27634460

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysine acetyltransferase 6A

decreases expression

ISO

Gallic Acid results in decreased expression of KAT6A mRNA

NCBI chr16:75,787,411...75,868,584
Ensembl chr16:75,787,411...75,866,099

G

lysine acetyltransferase 6B

decreases expression

ISO

Gallic Acid results in decreased expression of KAT6B mRNA

NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,688,811...2,844,343

G

lysine demethylase 3A

increases expression

ISO

Gallic Acid results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

3-ketodihydrosphingosine reductase

decreases expression

ISO

Gallic Acid results in decreased expression of KDSR mRNA

NCBI chr13:23,374,101...23,408,779
Ensembl chr13:23,376,779...23,408,897

G

kinesin family member 23

increases expression

ISO

Gallic Acid results in increased expression of KIF23 mRNA

NCBI chr 8:71,293,439...71,321,911
Ensembl chr 8:71,293,482...71,320,856

G

kelch-like family member 13

increases expression

ISO

Gallic Acid results in increased expression of KLHL13 mRNA

NCBI chr X:118,747,298...118,912,279
Ensembl chr X:118,747,298...118,855,035

G

lysine methyltransferase 2C

decreases expression

ISO

Gallic Acid results in decreased expression of KMT2C mRNA

NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:10,353,735...10,568,620

G

karyopherin subunit beta 1

increases expression

ISO

Gallic Acid results in increased expression of KPNB1 mRNA

NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,642,082...82,670,856

G

lysosomal-associated membrane protein 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in decreased expression of LAMP1 protein]

NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159

G

LanC like family member 3

decreases expression

ISO

Gallic Acid results in decreased expression of LANCL3 mRNA

NCBI chr X:16,150,991...16,282,425
Ensembl chr X:16,150,991...16,282,425

G

lysocardiolipin acyltransferase 1

decreases expression

ISO

Gallic Acid results in decreased expression of LCLAT1 mRNA

NCBI chr 6:27,980,749...28,125,076
Ensembl chr 6:27,982,936...28,112,511

G

lipid droplet associated hydrolase

increases expression

ISO

Gallic Acid results in increased expression of LDAH mRNA

NCBI chr 6:36,801,359...36,885,929
Ensembl chr 6:36,801,359...36,885,923

G

lactate dehydrogenase A

multiple interactions

EXP

Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

lactate dehydrogenase B

multiple interactions

EXP

Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHB protein]

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

low density lipoprotein receptor

increases expression

ISO

Gallic Acid results in increased expression of LDLR mRNA

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675

G

luteinizing hormone subunit beta

multiple interactions

EXP
ISO

Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of LHB protein]
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LHB protein]

PMID:34723416 PMID:35196152

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

DNA ligase 4

decreases expression

ISO

Gallic Acid results in decreased expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:86,220,279...86,229,926

G

LIM domain and actin binding 1

decreases expression

ISO

Gallic Acid results in decreased expression of LIMA1 mRNA

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:132,780,556...132,880,386

G

lipoyltransferase 1

increases expression

ISO

Gallic Acid results in increased expression of LIPT1 mRNA

NCBI chr 9:47,603,972...47,609,365
Ensembl chr 9:47,594,058...47,614,669

G

LIM domain containing preferred translocation partner in lipoma

decreases expression

ISO

Gallic Acid results in decreased expression of LPP mRNA

NCBI chr11:89,292,060...89,933,973
Ensembl chr11:89,305,187...89,805,264

G

mannose-6-phosphate receptor, cation dependent

increases expression

ISO

Gallic Acid results in increased expression of M6PR mRNA

NCBI chr 4:157,173,154...157,182,293
Ensembl chr 4:157,173,125...157,182,277

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in increased expression of MAP1LC3A protein]

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

[MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K1 protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

PMID:21420233 PMID:27087131 PMID:27634460

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 4

increases expression

ISO

Gallic Acid results in increased expression of MAP2K4 mRNA

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen-activated protein kinase kinase kinase 6

increases expression

ISO

Gallic Acid results in increased expression of MAP3K6 mRNA

NCBI chr 5:150,724,029...150,736,113
Ensembl chr 5:150,724,216...150,736,111

G

mitogen-activated protein kinase kinase kinase kinase 4

decreases expression

ISO

Gallic Acid results in decreased expression of MAP4K4 mRNA

NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:49,696,700...49,822,353

G

mitogen activated protein kinase 1

decreases expression
multiple interactions

ISO
EXP

Gallic Acid results in decreased expression of MAPK1 protein modified form
Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]
Gallic Acid inhibits the reaction [ALB modified form results in increased phosphorylation of MAPK1 protein]

PMID:22387266 PMID:24309158 PMID:27087131

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases expression
multiple interactions

ISO
EXP

Gallic Acid results in decreased expression of MAPK3 protein modified form
Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]]
Gallic Acid inhibits the reaction [ALB modified form results in increased phosphorylation of MAPK3 protein]

PMID:22387266 PMID:24309158 PMID:27087131

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

matrin 3

decreases expression

ISO

Gallic Acid results in decreased expression of MATR3 mRNA

NCBI chr18:27,428,190...27,474,421
Ensembl chr18:27,432,179...27,470,421

G

myoglobin

decreases expression

ISO

Gallic Acid results in decreased expression of MB mRNA

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:110,640,512...110,647,958

G

methyl-CpG binding domain protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of MBD1 mRNA

NCBI chr18:70,145,093...70,159,744
Ensembl chr18:70,145,114...70,159,703

G

myelin basic protein

multiple interactions

ISO

Gallic Acid inhibits the reaction [Bortezomib results in decreased expression of MBP protein]

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

malic enzyme 2

decreases expression

ISO

Gallic Acid results in decreased expression of ME2 mRNA

NCBI chr18:69,626,073...69,676,218
Ensembl chr18:69,626,087...69,676,218

G

mediator complex subunit 25

decreases expression

ISO

Gallic Acid results in decreased expression of MED25 mRNA

NCBI chr 1:104,496,447...104,513,061
Ensembl chr 1:104,496,447...104,512,391

G

multiple EGF-like-domains 8

increases expression

ISO

Gallic Acid results in increased expression of MEGF8 mRNA

NCBI chr 1:90,030,057...90,079,423
Ensembl chr 1:90,030,388...90,079,422

G

Meis homeobox 3

increases expression

ISO

Gallic Acid results in increased expression of MEIS3 mRNA

NCBI chr 1:85,986,602...86,000,873
Ensembl chr 1:85,990,050...86,000,873

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

ISO

Gallic Acid results in decreased expression of MET mRNA

NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821

G

methyltransferase 8, tRNA N3-cytidine

increases expression

ISO

Gallic Acid results in increased expression of METTL8 mRNA

NCBI chr 3:76,140,465...76,271,367
Ensembl chr 3:76,144,178...76,271,400

G

mitofusin 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of MFN1 protein]]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

O-6-methylguanine-DNA methyltransferase

decreases expression

ISO

Gallic Acid results in decreased expression of MGMT mRNA

NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482

G

microsomal glutathione S-transferase 1

multiple interactions
increases activity

EXP

1,1-diphenyl-2-picrylhydrazyl inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; Cyclosporine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; ferric chloride inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; Gallic Acid results in increased oxidation of and results in increased activity of MGST1 protein; Hemin inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; sodium arsenite inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]; triethylenediamine inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]

PMID:16125204 PMID:19111564

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

microRNA 122

decreases expression
multiple interactions

ISO
EXP

Gallic Acid results in decreased expression of MIR122 mRNA
Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of MIR122 mRNA]; Gallic Acid inhibits the reaction [Dust results in increased expression of MIR122 mRNA]

PMID:24165878 PMID:33953864 PMID:34745924

NCBI chr18:61,028,817...61,028,901

G

microRNA 200a

multiple interactions

EXP

Gallic Acid inhibits the reaction [Thioacetamide results in decreased expression of MIR200A mRNA]

NCBI chr 5:171,930,717...171,930,805

G

microRNA 204

increases expression

ISO

Gallic Acid results in increased expression of MIR204 mRNA

NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570

G

microRNA 21

increases expression
multiple interactions

EXP

Gallic Acid results in increased expression of MIR21 mRNA
Gallic Acid inhibits the reaction [Thioacetamide results in increased expression of MIR21 mRNA]

NCBI chr10:71,902,600...71,902,691

G

microRNA 29a

increases expression

ISO

Gallic Acid results in increased expression of MIR29A mRNA

NCBI chr 4:60,617,955...60,618,042

G

microRNA 30a

multiple interactions

EXP

Gallic Acid inhibits the reaction [Thioacetamide results in decreased expression of MIR30A mRNA]

NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:33,233,941...33,234,011

G

microRNA 34a

multiple interactions

EXP

Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of MIR34A mRNA]; Gallic Acid inhibits the reaction [Dust results in increased expression of MIR34A mRNA]

PMID:33953864 PMID:34745924

NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053

G

matrix metallopeptidase 2

decreases activity
multiple interactions
decreases expression

ISO
EXP

Gallic Acid results in decreased activity of MMP2 protein
Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP2 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP2 protein]
RHOB mutant form inhibits the reaction [Gallic Acid results in decreased expression of MMP2 protein]
Gallic Acid results in decreased expression of MMP2 mRNA; Gallic Acid results in decreased expression of MMP2 protein

PMID:22387266 PMID:23153558 PMID:24309158

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 7

multiple interactions
decreases expression

ISO

Gallic Acid inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Gallic Acid inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]
Gallic Acid results in decreased expression of MMP7 mRNA

PMID:17928719 PMID:22387266

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

matrix metallopeptidase 9

decreases expression
multiple interactions
decreases activity

ISO
EXP

Gallic Acid results in decreased expression of MMP9 mRNA
[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of and results in increased secretion of MMP9 protein]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]
Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 mRNA]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of MMP9 protein]
Gallic Acid results in decreased activity of MMP9 protein
Gallic Acid results in decreased expression of MMP9 mRNA; Gallic Acid results in decreased expression of MMP9 protein

PMID:16304905 PMID:22387266 PMID:24309158 PMID:27087131 PMID:27634460

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

MOB kinase activator 3C

increases expression

ISO

Gallic Acid results in increased expression of MOB3C mRNA

NCBI chr 5:134,542,929...134,552,017
Ensembl chr 5:134,543,243...134,551,991

G

MON2 homolog, regulator of endosome-to-Golgi trafficking

decreases expression

ISO

Gallic Acid results in decreased expression of MON2 mRNA

NCBI chr 7:60,534,772...60,613,467
Ensembl chr 7:60,534,772...60,613,467

G

myeloperoxidase

decreases activity
multiple interactions

ISO
EXP

Gallic Acid results in decreased activity of MPO protein
Gallic Acid analog inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Gallic Acid inhibits the reaction [Zearalenone results in increased activity of MPO protein]

PMID:23892052 PMID:24060682 PMID:34723416

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrial ribosomal protein L19

decreases expression

ISO

Gallic Acid results in decreased expression of MRPL19 mRNA

NCBI chr 4:116,079,654...116,083,883
Ensembl chr 4:116,079,654...116,083,883

G

MSL complex subunit 3

decreases expression

ISO

Gallic Acid results in decreased expression of MSL3 mRNA

NCBI chr X:29,210,388...29,228,060
Ensembl chr X:29,210,427...29,228,054

G

methionine sulfoxide reductase B3

decreases expression

ISO

Gallic Acid results in decreased expression of MSRB3 mRNA

NCBI chr 7:58,188,827...58,311,459
Ensembl chr 7:57,968,124...58,311,116

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of COX2 protein]]

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of ND1 protein]]

NCBI chr MT:2,740...3,694
Ensembl chr MT:2,729...3,685

G

methylenetetrahydrofolate reductase

decreases expression

ISO

Gallic Acid results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

matrix remodeling associated 7

decreases expression

ISO

Gallic Acid results in decreased expression of MXRA7 mRNA

NCBI chr10:102,501,848...102,530,231
Ensembl chr10:102,489,604...102,530,231

G

myosin heavy chain 7

multiple interactions

EXP

Gallic Acid inhibits the reaction [Cadmium results in increased expression of MYH7 mRNA]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

myosin Ib

increases expression

ISO

Gallic Acid results in increased expression of MYO1B mRNA

NCBI chr 9:57,182,059...57,344,335
Ensembl chr 9:57,181,987...57,344,328

G

myeloid zinc finger 1

decreases expression

ISO

Gallic Acid results in decreased expression of MZF1 mRNA

NCBI chr 1:82,742,709...82,755,069
Ensembl chr 1:82,742,726...82,753,820

G

N(alpha)-acetyltransferase 60, NatF catalytic subunit

decreases expression

ISO

Gallic Acid results in decreased expression of NAA60 mRNA

NCBI chr10:12,129,026...12,149,053
Ensembl chr10:12,131,429...12,139,262

G

N(alpha)-acetyltransferase 80, NatH catalytic subunit

increases expression

ISO

Gallic Acid results in increased expression of NAA80 mRNA

NCBI chr 8:117,132,957...117,136,207
Ensembl chr 8:117,133,494...117,136,207

G

nucleosome assembly protein 1-like 4

decreases expression

ISO

Gallic Acid results in decreased expression of NAP1L4 mRNA

NCBI chr 1:208,139,105...208,175,597
Ensembl chr 1:208,139,113...208,174,569

G

nuclear prelamin A recognition factor

increases expression

ISO

Gallic Acid results in increased expression of NARF mRNA

NCBI chr10:107,017,344...107,035,777
Ensembl chr10:107,016,510...107,037,283

G

neuron navigator 3

increases expression

ISO

Gallic Acid results in increased expression of NAV3 mRNA

NCBI chr 7:46,938,577...47,726,839
Ensembl chr 7:46,940,670...47,504,893

G

neutrophil cytosolic factor 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in increased expression of NCF1 protein]

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079

G

NADH:ubiquinone oxidoreductase subunit A3

increases expression

ISO

Gallic Acid results in increased expression of NDUFA3 mRNA

NCBI chr 1:74,512,928...74,515,558
Ensembl chr 1:74,512,928...74,515,558

G

NADH:ubiquinone oxidoreductase complex assembly factor 6

decreases expression

ISO

Gallic Acid results in decreased expression of NDUFAF6 mRNA

NCBI chr 5:28,945,014...28,969,230
Ensembl chr 5:28,945,014...28,969,667

G

NADH:ubiquinone oxidoreductase subunit B1

decreases expression

ISO

Gallic Acid results in decreased expression of NDUFB1 mRNA

NCBI chr 6:126,880,537...126,888,935
Ensembl chr 6:126,880,537...126,888,864

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of NDUFS1 mRNA]]

NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605

G

nei-like DNA glycosylase 1

decreases expression

ISO

Gallic Acid results in decreased expression of NEIL1 mRNA

NCBI chr 8:66,446,106...66,452,844
Ensembl chr 8:66,445,953...66,452,378

G

NIMA-related kinase 10

decreases expression

ISO

Gallic Acid results in decreased expression of NEK10 mRNA

NCBI chr15:12,808,981...13,013,679
Ensembl chr15:12,813,606...13,013,567

G

neurofibromin 1

decreases expression

ISO

Gallic Acid results in decreased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

nuclear factor of activated T-cells 4

decreases expression

ISO

Gallic Acid results in decreased expression of NFATC4 mRNA

NCBI chr15:33,256,912...33,284,522
Ensembl chr15:33,274,153...33,285,582

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO
EXP

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the localization of NFE2L2 protein]; Gallic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 mRNA]; Gallic Acid inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased activity of GPT protein]]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]
[Gallic Acid co-treated with Dust] results in increased expression of NFE2L2 mRNA; Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of NFE2L2 mRNA]

PMID:29061316 PMID:30853489 PMID:33953864 PMID:34745924

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor beta

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366

G

nuclear transcription factor, X-box binding-like 1

decreases expression

ISO

Gallic Acid results in decreased expression of NFXL1 mRNA

NCBI chr14:35,980,058...36,021,478
Ensembl chr14:35,980,057...36,023,281

G

NGG1 interacting factor 3 like 1

increases expression

ISO

Gallic Acid results in increased expression of NIF3L1 mRNA

NCBI chr 9:67,474,286...67,494,350
Ensembl chr 9:67,474,351...67,494,350

G

NKAP domain containing 1

increases expression

ISO

Gallic Acid results in increased expression of NKAPD1 mRNA

NCBI chr 8:59,852,037...59,863,295
Ensembl chr 8:59,852,726...59,863,181

G

NLR family, pyrin domain containing 1A

increases expression

ISO

Gallic Acid results in increased expression of NLRP1 mRNA

NCBI chr10:56,277,134...56,332,229
Ensembl chr10:56,277,134...56,323,880

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]
Gallic Acid inhibits the reaction [Acrylamide results in increased secretion of NOS2 protein]

PMID:31925992 PMID:37037409

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase trafficking

increases expression

ISO

Gallic Acid results in increased expression of NOSTRIN mRNA

NCBI chr 3:74,312,594...74,378,852
Ensembl chr 3:74,312,647...74,396,455

G

natriuretic peptide A

multiple interactions

EXP

Gallic Acid inhibits the reaction [Cadmium results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions

EXP

Gallic Acid inhibits the reaction [Cadmium results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nardilysin convertase

decreases expression

ISO

Gallic Acid results in decreased expression of NRDC mRNA

NCBI chr 5:128,983,395...129,047,578
Ensembl chr 5:128,984,446...129,050,141

G

neuritin 1-like

decreases expression

ISO

Gallic Acid results in decreased expression of NRN1L mRNA

NCBI chr19:50,696,281...50,697,741

G

NUBP iron-sulfur cluster assembly factor, mitochondrial

increases expression

ISO

Gallic Acid results in increased expression of NUBPL mRNA

NCBI chr 6:75,294,609...75,516,603
Ensembl chr 6:75,294,632...75,516,601

G

nuclear VCP-like

increases expression

ISO

Gallic Acid results in increased expression of NVL mRNA

NCBI chr13:95,385,389...95,438,490
Ensembl chr13:95,372,641...95,442,291

G

ornithine decarboxylase 1

multiple interactions

ISO

Gallic Acid inhibits the reaction [3-chloroperbenzoic acid results in increased activity of ODC1 protein]

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

odr-4 GPCR localization factor homolog

decreases expression

ISO

Gallic Acid results in decreased expression of ODR4 mRNA

NCBI chr13:64,925,573...64,974,395
Ensembl chr13:64,944,713...64,974,316

G

origin recognition complex, subunit 4

increases expression

ISO

Gallic Acid results in increased expression of ORC4 mRNA

NCBI chr 3:53,700,046...53,743,293
Ensembl chr 3:53,703,615...53,742,264

G

oxysterol binding protein-like 6

increases expression

ISO

Gallic Acid results in increased expression of OSBPL6 mRNA

NCBI chr 3:81,751,020...81,948,186
Ensembl chr 3:81,750,982...81,946,615

G

parkin coregulated like

decreases expression

ISO

Gallic Acid results in decreased expression of PACRGL mRNA

NCBI chr14:66,744,625...66,769,593
Ensembl chr14:66,744,625...66,769,631

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

Gallic Acid results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Gallic Acid results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

propionyl-CoA carboxylase subunit alpha

decreases expression

ISO

Gallic Acid results in decreased expression of PCCA mRNA

NCBI chr15:106,034,586...106,374,908
Ensembl chr15:106,034,610...106,374,908

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

ISO

Gallic Acid results in increased expression of PCK2 mRNA

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864

G

proliferating cell nuclear antigen

multiple interactions

EXP

Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

PDZ and LIM domain 5

decreases expression

ISO

Gallic Acid results in decreased expression of PDLIM5 mRNA

NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:233,628,503...233,793,528

G

pancreatic and duodenal homeobox 1

increases expression

ISO

Gallic Acid results in increased expression of PDX1 protein

NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156

G

period circadian regulator 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]

NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211

G

period circadian regulator 2

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER2 mRNA]

NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression

ISO

Gallic Acid results in increased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

phosphofructokinase, muscle

increases expression

ISO

Gallic Acid results in increased expression of PFKM mRNA

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

protein inhibitor of activated STAT, 2

increases expression

ISO

Gallic Acid results in increased expression of PIAS2 mRNA

NCBI chr18:72,883,008...72,989,486
Ensembl chr18:72,882,890...73,006,662

G

phosphatidylinositol transfer protein, beta

decreases expression

ISO

Gallic Acid results in decreased expression of PITPNB mRNA

NCBI chr12:50,909,140...50,958,193
Ensembl chr12:50,909,143...50,958,140

G

phosphatidylinositol-specific phospholipase C, X domain containing 1

decreases expression

ISO

Gallic Acid results in decreased expression of PLCXD1 mRNA

NCBI chr12:52,238,450...52,241,884
Ensembl chr12:52,238,623...52,241,865

G

pleckstrin homology and RhoGEF domain containing G4

increases expression

ISO

Gallic Acid results in increased expression of PLEKHG4 mRNA

NCBI chr19:50,161,722...50,176,491
Ensembl chr19:50,159,754...50,182,133

G

plastin 3

decreases expression

ISO

Gallic Acid results in decreased expression of PLS3 mRNA

NCBI chr X:116,401,247...116,495,898
Ensembl chr X:116,401,293...116,495,893

G

peripheral myelin protein 22

decreases expression

ISO

Gallic Acid results in decreased expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

patatin-like phospholipase domain containing 8

decreases expression

ISO

Gallic Acid results in decreased expression of PNPLA8 mRNA

NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:67,056,697...67,120,512

G

POP1 homolog, ribonuclease P/MRP subunit

increases expression

ISO

Gallic Acid results in increased expression of POP1 mRNA

NCBI chr 7:67,590,502...67,618,187
Ensembl chr 7:67,590,522...67,618,293

G

POU class 2 homeobox 1

decreases expression

ISO

Gallic Acid results in decreased expression of POU2F1 mRNA

NCBI chr13:80,653,602...80,796,279
Ensembl chr13:80,663,714...80,796,356

G

peroxisome proliferator-activated receptor gamma

increases expression
increases activity

ISO
EXP

Gallic Acid results in increased expression of PPARG protein
Gallic Acid results in increased activity of PPARG protein

PMID:24036142 PMID:24433871

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase 1, regulatory subunit 18

increases expression

ISO

Gallic Acid results in increased expression of PPP1R18 mRNA

NCBI chr20:2,882,370...2,892,329
Ensembl chr20:2,882,369...2,896,605

G

protein phosphatase 2, regulatory subunit B'', gamma

decreases expression

ISO

Gallic Acid results in decreased expression of PPP2R3C mRNA

NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:78,382,855...78,406,201

G

protein phosphatase 3 catalytic subunit alpha

increases expression

ISO

Gallic Acid results in increased expression of PPP3CA mRNA

NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554

G

palmitoyl-protein thioesterase 1

decreases expression

ISO

Gallic Acid results in decreased expression of PPT1 mRNA

NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200

G

PR/SET domain 10

increases expression

ISO

Gallic Acid results in increased expression of PRDM10 mRNA

NCBI chr 8:37,982,210...38,085,907
Ensembl chr 8:37,982,403...38,085,907

G

PR/SET domain 15

decreases expression

ISO

Gallic Acid results in decreased expression of PRDM15 mRNA

NCBI chr11:50,633,973...50,691,624
Ensembl chr11:50,633,973...50,691,823

G

PR/SET domain 5

increases expression

ISO

Gallic Acid results in increased expression of PRDM5 mRNA

NCBI chr 4:96,405,492...96,567,647
Ensembl chr 4:96,405,493...96,567,647

G

protein kinase cAMP-activated catalytic subunit beta

decreases expression

ISO

Gallic Acid results in decreased expression of PRKACB mRNA

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase C, alpha

decreases activity

ISO

Gallic Acid results in decreased activity of PRKCA protein

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, eta

decreases expression

ISO

Gallic Acid results in decreased expression of PRKCH mRNA

NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:98,027,646...98,226,477

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

ISO

Gallic Acid results in decreased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

protein arginine methyltransferase 1

decreases expression

ISO

Gallic Acid results in decreased expression of PRMT1 mRNA

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:104,595,335...104,604,827

G

phosphoribosyl pyrophosphate synthetase-associated protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of PRPSAP1 mRNA

NCBI chr10:102,199,949...102,221,642
Ensembl chr10:102,199,950...102,221,642

G

proline rich 13

increases expression

ISO

Gallic Acid results in increased expression of PRR13 mRNA

NCBI chr 7:135,471,040...135,474,344
Ensembl chr 7:135,470,933...135,474,579

G

prune homolog 2 with BCH domain

increases expression

ISO

Gallic Acid results in increased expression of PRUNE2 mRNA

NCBI chr 1:223,779,617...224,130,058
Ensembl chr 1:223,969,102...224,051,592

G

phosphatase and tensin homolog

increases secretion

ISO

Gallic Acid results in increased secretion of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

phosphotriesterase related

decreases expression

ISO

Gallic Acid results in decreased expression of PTER mRNA

NCBI chr17:80,967,463...81,028,707
Ensembl chr17:80,967,477...81,030,099

G

prostaglandin reductase 1

increases expression

ISO

[Gallic acid cotreated with calycosin or formononetin] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells

RGD

NCBI chr 5:78,579,060...78,597,671
Ensembl chr 5:78,579,057...78,597,811

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

ISO
EXP

Gallic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Gallic Acid promotes the reaction [Imatinib Mesylate results in decreased expression of PTGS2 protein]; Imatinib Mesylate promotes the reaction [Gallic Acid results in decreased expression of PTGS2 protein]
Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]

PMID:21420233 PMID:22245431 PMID:24836925 PMID:31925992

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2

decreases phosphorylation

ISO

Gallic Acid results in decreased phosphorylation of PTK2 protein

NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091

G

protein tyrosine phosphatase, receptor type, F

decreases expression

ISO

Gallic Acid results in decreased expression of PTPRF mRNA

NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426

G

protein tyrosine phosphatase, receptor type, J

decreases expression

ISO

Gallic Acid results in decreased expression of PTPRJ mRNA

NCBI chr 3:96,861,785...97,017,702
Ensembl chr 3:96,861,785...97,017,656

G

protein tyrosine phosphatase, receptor type, K

increases expression

ISO

Gallic Acid results in increased expression of PTPRK mRNA

NCBI chr 1:18,557,091...19,056,297
Ensembl chr 1:18,558,365...19,056,107

G

peptidyl-tRNA hydrolase 1 homolog

increases expression

ISO

Gallic Acid results in increased expression of PTRH1 mRNA

NCBI chr 3:36,462,575...36,475,605
Ensembl chr 3:36,462,575...36,476,139

G

pseudouridine synthase 3

decreases expression

ISO

Gallic Acid results in decreased expression of PUS3 mRNA

NCBI chr 8:42,168,194...42,176,527
Ensembl chr 8:42,168,251...42,176,522

G

paxillin

decreases phosphorylation

ISO

Gallic Acid results in decreased phosphorylation of PXN protein

NCBI chr12:46,721,546...46,768,706
Ensembl chr12:46,721,546...46,768,697

G

PYD and CARD domain containing

decreases expression

ISO

Gallic Acid results in decreased expression of PYCARD mRNA

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

RAB30, member RAS oncogene family

decreases expression

ISO

Gallic Acid results in decreased expression of RAB30 mRNA

NCBI chr 1:156,216,137...156,310,778
Ensembl chr 1:156,216,137...156,310,778

G

RAB, member of RAS oncogene family like 2

increases expression

ISO

Gallic Acid results in increased expression of RABL2B mRNA

NCBI chr 7:122,531,787...122,540,500
Ensembl chr 7:122,531,792...122,540,395

G

Rac family small GTPase 1

decreases expression

ISO

Gallic Acid results in decreased expression of RAC1 protein

NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109

G

Rac GTPase-activating protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of RACGAP1 mRNA

NCBI chr 7:132,629,789...132,659,738
Ensembl chr 7:132,620,595...132,659,738

G

RAD51 recombinase

increases expression

ISO

Gallic Acid results in increased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:126,554,190...126,579,469

G

RAP1B, member of RAS oncogene family

decreases expression

ISO

Gallic Acid results in decreased expression of RAP1B mRNA

NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:55,308,922...55,342,217

G

ribonucleoprotein, PTB-binding 2

decreases expression

ISO

Gallic Acid results in decreased expression of RAVER2 mRNA

NCBI chr 5:120,796,807...120,898,281
Ensembl chr 5:120,800,126...120,895,825

G

RNA binding fox-1 homolog 2

increases expression

ISO

Gallic Acid results in increased expression of RBFOX2 mRNA

NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:110,691,230...110,934,987

G

RELA proto-oncogene, NF-kB subunit

increases activity
multiple interactions
decreases expression

ISO
EXP

Gallic Acid analog results in increased activity of RELA protein
Gallic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]; Gallic Acid inhibits the reaction [Glucose results in increased expression of RELA protein]
Gallic Acid results in decreased expression of RELA protein
[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; [MAP2K1 protein modified form co-treated with AKT1 protein modified form] inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]]; Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; Gallic Acid inhibits the reaction [TNF protein affects the localization of and affects the activity of RELA protein]

PMID:19577552 PMID:21420233 PMID:22245431 PMID:26341651 PMID:27087131 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing

decreases expression

ISO

Gallic Acid results in decreased expression of RELCH mRNA

NCBI chr13:22,321,495...22,417,371
Ensembl chr13:22,321,542...22,417,371

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

increases expression

ISO

Gallic Acid results in increased expression of RFFL mRNA

NCBI chr10:68,238,273...68,301,225
Ensembl chr10:68,238,273...68,321,902

G

similar to RIKEN cDNA 3110043O21

decreases expression

ISO

Gallic Acid results in decreased expression of C9ORF72 mRNA

NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:54,562,570...54,587,637

G

regulator of G-protein signaling 20

increases expression

ISO

Gallic Acid results in increased expression of RGS20 mRNA

NCBI chr 5:19,282,249...19,412,122
Ensembl chr 5:19,282,153...19,413,286

G

ras homolog family member A

decreases expression

ISO

Gallic Acid results in decreased expression of RHOA protein

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302

G

ras homolog family member B

increases expression
increases response to substance
multiple interactions

ISO

Gallic Acid results in increased expression of RHOB mRNA; Gallic Acid results in increased expression of RHOB protein
RHOB protein results in increased susceptibility to Gallic Acid
RHOB mutant form inhibits the reaction [Gallic Acid results in decreased expression of MMP2 protein]; RHOB mutant form inhibits the reaction [Gallic Acid results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:37,075,015...37,112,772

G

receptor interacting serine/threonine kinase 1

multiple interactions

ISO

Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK1 protein]

NCBI chr17:31,044,983...31,077,167
Ensembl chr17:31,044,994...31,077,167

G

receptor-interacting serine-threonine kinase 3

multiple interactions

ISO

Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]; Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK3 protein]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]]

NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025

G

ribonuclease H2, subunit B

decreases expression

ISO

Gallic Acid results in decreased expression of RNASEH2B mRNA

NCBI chr15:40,717,252...40,770,826
Ensembl chr15:40,717,232...40,770,825

G

RNA binding protein with serine rich domain 1

decreases expression
increases expression

ISO

Gallic Acid results in decreased expression of RNPS1 mRNA
Gallic Acid results in increased expression of RNPS1 mRNA

NCBI chr10:13,950,151...13,960,396
Ensembl chr10:13,950,184...13,960,393

G

ribosomal protein L32

decreases expression

ISO

Gallic Acid results in decreased expression of RPL32 mRNA

NCBI chr 4:150,536,650...150,540,214
Ensembl chr 4:150,536,646...150,540,214

G

ribosomal protein L5

increases expression

ISO

Gallic Acid results in increased expression of RPL5 mRNA

NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,988,793...1,995,225

G

ribosomal protein S6 kinase A1

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA1 protein]

NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044

G

ribosomal protein S6 kinase A5

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA5 protein]

NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856

G

ribosomal protein S6 kinase C1

increases expression
decreases expression

ISO

Gallic Acid results in increased expression of RPS6KC1 mRNA
Gallic Acid results in decreased expression of RPS6KC1 mRNA

NCBI chr13:104,877,296...105,021,490
Ensembl chr13:104,877,296...105,021,435

G

reticulon 2

decreases expression

ISO

Gallic Acid results in decreased expression of RTN2 mRNA

NCBI chr 1:88,063,124...88,076,082
Ensembl chr 1:88,063,119...88,076,043

G

RUS family member 1

increases expression

ISO

Gallic Acid results in increased expression of RUSF1 mRNA

NCBI chr 1:192,282,708...192,312,119
Ensembl chr 1:192,282,711...192,311,137

G

secernin 3

decreases expression

ISO

Gallic Acid results in decreased expression of SCRN3 mRNA

NCBI chr 3:78,596,330...78,621,132
Ensembl chr 3:78,596,386...78,621,132

G

serine dehydratase-like

decreases expression

ISO

Gallic Acid results in decreased expression of SDSL mRNA

NCBI chr12:41,760,252...41,770,465
Ensembl chr12:41,760,252...41,770,465

G

SEC22 homolog A, vesicle trafficking protein

increases expression

ISO

Gallic Acid results in increased expression of SEC22A mRNA

NCBI chr11:78,907,552...78,967,575
Ensembl chr11:78,907,470...78,970,447

G

Sec23 homolog B, COPII coat complex component

decreases expression

ISO

Gallic Acid results in decreased expression of SEC23B mRNA

NCBI chr 3:152,392,340...152,434,813
Ensembl chr 3:152,392,308...152,434,800

G

selectin E

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

selenoprotein F

increases expression

ISO

Gallic Acid results in increased expression of SELENOF mRNA

NCBI chr 2:236,302,439...236,335,216
Ensembl chr 2:236,302,683...236,335,210

G

SET domain bifurcated histone lysine methyltransferase 1

decreases expression

ISO

Gallic Acid results in decreased expression of SETDB1 mRNA

NCBI chr 2:185,587,722...185,619,084
Ensembl chr 2:185,587,722...185,618,982

G

sarcoglycan, epsilon

increases expression

ISO

Gallic Acid results in increased expression of SGCE mRNA

NCBI chr 4:33,738,066...33,808,907
Ensembl chr 4:33,737,814...33,808,908

G

sirtuin 1

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

SLAIN motif family, member 1

increases expression

ISO

Gallic Acid results in increased expression of SLAIN1 mRNA

NCBI chr15:86,897,476...86,957,113
Ensembl chr15:86,897,476...86,957,113

G

solute carrier family 12 member 2

increases expression

ISO

Gallic Acid results in increased expression of SLC12A2 mRNA

NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470

G

solute carrier family 12, member 8

decreases expression

ISO

Gallic Acid results in decreased expression of SLC12A8 mRNA

NCBI chr11:80,622,000...80,771,674
Ensembl chr11:80,622,000...80,771,659

G

solute carrier family 25 member 23

decreases expression

ISO

Gallic Acid results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,969,633...1,985,365
Ensembl chr 9:1,969,357...1,985,365

G

solute carrier family 2 member 8

decreases expression

ISO

Gallic Acid results in decreased expression of SLC2A8 mRNA

NCBI chr 3:36,672,589...36,682,206
Ensembl chr 3:36,672,591...36,682,194

G

solute carrier family 35 member A3

increases expression

ISO

Gallic Acid results in increased expression of SLC35A3 mRNA

NCBI chr 2:207,305,008...207,344,225
Ensembl chr 2:207,307,947...207,344,155

G

solute carrier family 35, member E2B

decreases expression

ISO

Gallic Acid results in decreased expression of SLC35E2B mRNA

NCBI chr 5:171,465,222...171,493,317
Ensembl chr 5:171,475,386...171,493,315

G

solute carrier family 4 member 1 adaptor protein

increases expression

ISO

Gallic Acid results in increased expression of SLC4A1AP mRNA

NCBI chr 6:30,625,931...30,653,859
Ensembl chr 6:30,625,931...30,653,792

G

solute carrier family 9 member B2

decreases expression

ISO

Gallic Acid results in decreased expression of SLC9B2 mRNA

NCBI chr 2:226,400,358...226,435,039
Ensembl chr 2:226,410,263...226,435,030

G

SMAD family member 3

multiple interactions

EXP

Gallic Acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

SMAD family member 4

increases expression

ISO

Gallic Acid results in increased expression of SMAD4 mRNA

NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

decreases expression

ISO

Gallic Acid results in decreased expression of SMARCA4 mRNA

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:28,443,810...28,535,070

G

SWI/SNF related BAF chromatin remodeling complex subunit E1

decreases expression

ISO

Gallic Acid results in decreased expression of SMARCE1 mRNA

NCBI chr10:84,655,468...84,678,259
Ensembl chr10:84,655,468...84,676,185

G

synuclein alpha

multiple interactions

ISO

Gallic Acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

sorting nexin 12

increases expression

ISO

Gallic Acid results in increased expression of SNX12 mRNA

NCBI chr X:70,267,013...70,396,948
Ensembl chr X:70,381,837...70,397,164

G

superoxide dismutase 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [Paraquat results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

SRY-box transcription factor 9

decreases expression

EXP

Gallic Acid results in decreased expression of SOX9 mRNA

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

spermatogenesis associated, serine-rich 2-like

decreases expression

ISO

Gallic Acid results in decreased expression of SPATS2L mRNA

NCBI chr 9:66,814,217...66,988,084
Ensembl chr 9:66,814,228...66,988,578

G

sphingosine kinase 2

increases expression

ISO

Gallic Acid results in increased expression of SPHK2 mRNA

NCBI chr 1:105,317,332...105,324,985
Ensembl chr 1:105,317,333...105,321,637

G

spectrin, alpha, non-erythrocytic 1

decreases expression

ISO

Gallic Acid results in decreased expression of SPTAN1 mRNA

NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:33,607,210...33,703,889

G

sequestosome 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
decreases phosphorylation

ISO

Gallic Acid inhibits the reaction [EGF protein results in increased activity of SRC protein]; SRC protein modified form affects the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; SRC protein modified form inhibits the reaction [Gallic Acid inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]]
Gallic Acid results in decreased phosphorylation of SRC protein

PMID:27087131 PMID:38100242

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

increases expression

ISO

Gallic Acid results in increased expression of ST6GALNAC6 mRNA

NCBI chr 3:36,283,573...36,305,217
Ensembl chr 3:36,283,629...36,305,216

G

STAG1 cohesin complex component

decreases expression

ISO

Gallic Acid results in decreased expression of STAG1 mRNA

NCBI chr 8:110,057,981...110,443,666
Ensembl chr 8:110,058,056...110,443,665

G

StAR-related lipid transfer domain containing 10

increases expression

ISO

Gallic Acid results in increased expression of STARD10 mRNA

NCBI chr 1:165,130,408...165,159,134
Ensembl chr 1:165,128,151...165,159,135

G

staufen double-stranded RNA binding protein 2

increases expression

ISO

Gallic Acid results in increased expression of STAU2 mRNA

NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:7,624,019...7,868,204

G

STING1 ER exit protein 1

increases expression

ISO

Gallic Acid results in increased expression of STEEP1 mRNA

NCBI chr X:120,953,335...120,979,861
Ensembl chr X:120,926,647...120,979,861

G

sulfotransferase family 1A member 1

multiple interactions
increases expression
increases activity

ISO
EXP

Cycloheximide inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 mRNA]; Dactinomycin inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 mRNA]; pyrazolanthrone inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 protein]; SB 203580 inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 protein]
Gallic Acid results in increased activity of SULT1A1 protein

PMID:16308312 PMID:16443358

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 2A member 1

increases activity
increases expression

EXP

Gallic Acid results in increased activity of SULT2A1 protein
Gallic Acid results in increased expression of SULT2A1 mRNA

NCBI chr 1:84,582,011...84,639,001

G

sulfatase modifying factor 2

decreases expression

ISO

Gallic Acid results in decreased expression of SUMF2 mRNA

NCBI chr12:32,489,671...32,507,941
Ensembl chr12:32,489,671...32,507,928

G

SPT5 homolog, DSIF elongation factor subunit

increases expression

ISO

Gallic Acid results in increased expression of SUPT5H mRNA

NCBI chr 1:92,714,276...92,745,489
Ensembl chr 1:92,714,281...92,744,445

G

syntabulin

decreases expression

ISO

Gallic Acid results in decreased expression of SYBU mRNA

NCBI chr 7:77,731,662...77,833,413
Ensembl chr 7:77,731,605...77,833,686

G

synaptojanin 2

decreases expression

ISO

Gallic Acid results in decreased expression of SYNJ2 mRNA

NCBI chr 1:48,923,742...49,027,153
Ensembl chr 1:48,923,737...49,038,650

G

synaptophysin-like 1

decreases expression

ISO

Gallic Acid results in decreased expression of SYPL1 mRNA

NCBI chr 6:55,292,555...55,311,519
Ensembl chr 6:55,292,567...55,314,714

G

transforming, acidic coiled-coil containing protein 3

decreases expression

ISO

Gallic Acid results in decreased expression of TACC3 mRNA

NCBI chr14:81,275,755...81,289,894
Ensembl chr14:81,275,755...81,289,698

G

TATA-box binding protein associated factor 6

increases expression

ISO

Gallic Acid results in increased expression of TAF6 mRNA

NCBI chr12:22,169,570...22,178,031
Ensembl chr12:22,168,718...22,177,938

G

Tax1 binding protein 1

decreases expression

ISO

Gallic Acid results in decreased expression of TAX1BP1 mRNA

NCBI chr 4:83,152,549...83,208,463
Ensembl chr 4:83,110,062...83,209,657

G

TBC1 domain family, member 15

increases expression

ISO

Gallic Acid results in increased expression of TBC1D15 mRNA

NCBI chr 7:52,690,770...52,746,309
Ensembl chr 7:52,690,770...52,746,303

G

TBC1 domain family, member 2B

decreases expression

ISO

Gallic Acid results in decreased expression of TBC1D2B mRNA

NCBI chr 8:99,626,019...99,694,669
Ensembl chr 8:99,626,019...99,694,637

G

tubulin folding cofactor B

decreases expression

ISO

Gallic Acid results in decreased expression of TBCB mRNA

NCBI chr 1:94,605,100...94,610,949
Ensembl chr 1:94,605,101...94,610,949

G

T-box transcription factor 15

decreases expression

ISO

Gallic Acid results in decreased expression of TBX15 mRNA

NCBI chr 2:189,265,373...189,376,466
Ensembl chr 2:189,265,373...189,376,466

G

transcription factor 7 like 2

decreases expression

ISO

Gallic Acid results in decreased expression of TCF7L2 mRNA

NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225

G

TEA domain transcription factor 2

decreases expression

ISO

Gallic Acid results in decreased expression of TEAD2 mRNA

NCBI chr 1:104,838,795...104,855,635
Ensembl chr 1:104,838,623...104,855,630

G

testis expressed 264, ER-phagy receptor

decreases expression

ISO

Gallic Acid results in decreased expression of TEX264 mRNA

NCBI chr 8:116,174,517...116,201,578
Ensembl chr 8:116,174,518...116,201,667

G

transcription factor EB

multiple interactions

EXP

Gallic Acid inhibits the reaction [Bortezomib results in increased phosphorylation of and affects the localization of TFEB protein]

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transforming growth factor, beta 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; Gallic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Gallic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]

PMID:26341651 PMID:29331653 PMID:32278740

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

translocase of inner mitochondrial membrane 50

increases expression

ISO

Gallic Acid results in increased expression of TIMM50 mRNA

NCBI chr 1:92,702,437...92,710,311
Ensembl chr 1:92,702,437...92,710,311

G

TIMP metallopeptidase inhibitor 1

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP1 mRNA]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TIMP2 mRNA]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

multiple interactions

EXP

Gallic Acid inhibits the reaction [ALB modified form results in decreased expression of TIMP3 mRNA]

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

TERF1 interacting nuclear factor 2

increases expression

ISO

Gallic Acid results in increased expression of TINF2 mRNA

NCBI chr15:33,140,611...33,146,930
Ensembl chr15:33,140,714...33,146,930

G

thymidine kinase 2

decreases expression

ISO

Gallic Acid results in decreased expression of TK2 mRNA

NCBI chr19:713,043...737,345
Ensembl chr19:715,318...738,355

G

talin 1

decreases expression

ISO

Gallic Acid results in decreased expression of TLN1 protein

NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687

G

transmembrane 7 superfamily member 3

decreases expression

ISO

Gallic Acid results in decreased expression of TM7SF3 mRNA

NCBI chr 4:181,248,819...181,280,844
Ensembl chr 4:181,248,822...181,280,844

G

transmembrane BAX inhibitor motif containing 6

increases expression

ISO

Gallic Acid results in increased expression of TMBIM6 mRNA

NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:132,386,134...132,422,492

G

transmembrane protein 106C

decreases expression

ISO

Gallic Acid results in decreased expression of TMEM106C mRNA

NCBI chr 7:130,967,526...130,973,205
Ensembl chr 7:130,967,606...130,973,207

G

transmembrane protein 129, E3 ubiquitin ligase

increases expression

ISO

Gallic Acid results in increased expression of TMEM129 mRNA

NCBI chr14:81,289,852...81,295,416
Ensembl chr14:81,290,351...81,295,417

G

transmembrane protein 170A

increases expression

ISO

Gallic Acid results in increased expression of TMEM170A mRNA

NCBI chr19:56,743,221...56,756,085

G

transmembrane protein 205

increases expression

ISO

Gallic Acid results in increased expression of TMEM205 mRNA

NCBI chr 8:28,728,172...28,733,908
Ensembl chr 8:28,728,172...28,733,908

G

transmembrane protein 218

decreases expression

ISO

Gallic Acid results in decreased expression of TMEM218 mRNA

NCBI chr 8:45,113,368...45,128,739
Ensembl chr 8:45,113,427...45,129,152

G

transmembrane protein 250

decreases expression

ISO

Gallic Acid results in decreased expression of TMEM250 mRNA

NCBI chr 3:29,360,770...29,364,756
Ensembl chr 3:29,360,770...29,364,462

G

transmembrane and ubiquitin-like domain containing 1

increases expression

ISO

Gallic Acid results in increased expression of TMUB1 mRNA

NCBI chr 4:11,621,931...11,624,497
Ensembl chr 4:11,621,508...11,624,499

G

tumor necrosis factor

multiple interactions

ISO
EXP

Gallic Acid inhibits the reaction [TNF protein affects the localization of and affects the activity of RELA protein]; Gallic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of SELE protein]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAP2K1 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA1 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KA5 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; Gallic Acid inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
Gallic Acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Gallic Acid affects the reaction [[Dietary Fats co-treated with Dust] affects the expression of TNF mRNA]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [ALB modified form results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; Gallic Acid inhibits the reaction [Dust results in increased expression of TNF mRNA]; Gallic Acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; Gallic Acid inhibits the reaction [Zearalenone results in increased expression of TNF protein]

PMID:21420233 PMID:24309158 PMID:26341651 PMID:30611791 PMID:31306686 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

increases expression

ISO

Gallic Acid results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

TNF alpha induced protein 8 like 1

decreases expression

ISO

Gallic Acid results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:1,075,724...1,088,256
Ensembl chr 9:1,055,801...1,092,803

G

troponin T2, cardiac type

multiple interactions

EXP

Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

G

tensin 1

decreases expression

ISO

Gallic Acid results in decreased expression of TNS1 protein

NCBI chr 9:82,941,068...83,152,007
Ensembl chr 9:82,941,068...83,152,007

G

tumor protein p53

decreases expression
increases expression
multiple interactions

ISO

Gallic Acid results in decreased expression of TP53 mRNA
Gallic Acid results in increased expression of TP53 mRNA; Gallic Acid results in increased expression of TP53 protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of TP53 protein

PMID:21887735 PMID:33002289

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tropomyosin 3

decreases expression

ISO

Gallic Acid results in decreased expression of TPM3 mRNA

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

TNF receptor-associated factor 5

decreases expression

ISO

Gallic Acid results in decreased expression of TRAF5 mRNA

NCBI chr13:106,100,921...106,149,724
Ensembl chr13:106,103,291...106,149,707

G

TRAF-interacting protein

decreases expression

ISO

Gallic Acid results in decreased expression of TRAIP mRNA

NCBI chr 8:117,520,476...117,540,253
Ensembl chr 8:117,520,441...117,540,253

G

trafficking protein particle complex subunit 9

increases expression

ISO

Gallic Acid results in increased expression of TRAPPC9 mRNA

NCBI chr 7:106,410,339...106,887,364
Ensembl chr 7:106,410,339...106,887,363

G

tripartite motif-containing 36

increases expression

ISO

Gallic Acid results in increased expression of TRIM36 mRNA

NCBI chr18:41,047,657...41,099,497
Ensembl chr18:41,047,657...41,104,704

G

tripartite motif-containing 45

decreases expression

ISO

Gallic Acid results in decreased expression of TRIM45 mRNA

NCBI chr 2:191,038,355...191,047,826
Ensembl chr 2:191,038,356...191,047,825

G

triple QxxK/R motif containing

decreases expression

ISO

Gallic Acid results in decreased expression of TRIQK mRNA

NCBI chr 5:31,188,816...31,261,705
Ensembl chr 5:31,188,839...31,262,108

G

tRNA methyltransferase 10A

decreases expression

ISO

Gallic Acid results in decreased expression of TRMT10A mRNA

NCBI chr 2:229,342,853...229,357,573
Ensembl chr 2:229,342,864...229,360,108

G

transient receptor potential cation channel, subfamily C, member 5

multiple interactions

ISO

Gallic Acid inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]; Gallic Acid inhibits the reaction [Hydrogen Peroxide promotes the reaction [TRPC5 protein results in increased transport of Calcium]]

NCBI chr X:112,742,828...113,027,638
Ensembl chr X:112,742,828...113,027,638

G

TSC22 domain family, member 3

increases expression

ISO

Gallic Acid results in increased expression of TSC22D3 mRNA

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

thyroid stimulating hormone subunit beta

multiple interactions

EXP

Gallic Acid inhibits the reaction [Zearalenone results in decreased expression of TSHB protein]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

tetraspanin 9

decreases expression

ISO

Gallic Acid results in decreased expression of TSPAN9 mRNA

NCBI chr 4:162,500,029...162,681,699
Ensembl chr 4:162,500,029...162,574,208

G

alpha tocopherol transfer protein like

decreases expression

ISO

Gallic Acid results in decreased expression of TTPAL mRNA

NCBI chr 3:172,697,683...172,715,973
Ensembl chr 3:172,697,729...172,715,983

G

ubiquitin A-52 residue ribosomal protein fusion product 1

decreases expression

ISO

Gallic Acid results in decreased expression of UBA52 mRNA

NCBI chr16:18,952,583...18,954,780

G

ubiquitin B

decreases expression

ISO

Gallic Acid results in decreased expression of UBB mRNA

NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,727,701...47,750,335

G

ubiquitin-conjugating enzyme E2, J2

decreases expression

ISO

Gallic Acid results in decreased expression of UBE2J2 mRNA

NCBI chr 5:171,815,607...171,830,037
Ensembl chr 5:171,815,623...171,830,034

G

UBX domain protein 6

increases expression

ISO

Gallic Acid results in increased expression of UBXN6 mRNA

NCBI chr 9:988,051...993,221
Ensembl chr 9:988,051...993,497

G

ubiquinol-cytochrome c reductase complex assembly factor 1

increases expression

ISO

Gallic Acid results in increased expression of UQCC1 mRNA

NCBI chr 3:164,813,398...164,905,892
Ensembl chr 3:164,814,424...164,905,778

G

ubiquinol cytochrome c reductase core protein 2

multiple interactions

ISO

[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]; BMAL1 protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of UQCRC2 protein]]

NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:184,599,212...184,630,946

G

ubiquitin specific peptidase 19

decreases expression
increases expression

ISO

Gallic Acid results in decreased expression of USP19 mRNA
Gallic Acid results in increased expression of USP19 mRNA

NCBI chr 8:118,069,227...118,080,283
Ensembl chr 8:118,069,240...118,080,300

G

ubiquitin specific peptidase 2

decreases expression

ISO

Gallic Acid results in decreased expression of USP2 mRNA

NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:53,308,303...53,336,794

G

ubiquitin specific peptidase 21

decreases expression

ISO

Gallic Acid results in decreased expression of USP21 mRNA

NCBI chr13:86,235,122...86,241,663
Ensembl chr13:86,235,081...86,241,714

G

ubiquitin specific peptidase 3

increases expression

ISO

Gallic Acid results in increased expression of USP3 mRNA

NCBI chr 8:75,973,278...76,049,151
Ensembl chr 8:75,974,615...76,049,153

G

ubiquitin specific peptidase 32

decreases expression

ISO

Gallic Acid results in decreased expression of USP32 mRNA

NCBI chr10:70,353,310...70,538,008
Ensembl chr10:70,353,310...70,538,324

G

ubiquitin specific peptidase 45

decreases expression

ISO

Gallic Acid results in decreased expression of USP45 mRNA

NCBI chr 5:40,115,394...40,188,861
Ensembl chr 5:40,115,267...40,188,861

G

utrophin

increases expression

ISO

Gallic Acid results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

G

vascular cell adhesion molecule 1

multiple interactions

EXP

Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of VCAM1 mRNA]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

multiple interactions
decreases expression
decreases secretion

ISO

AKT1 protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]; Gallic Acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; HIF1A protein inhibits the reaction [Gallic Acid results in decreased expression of VEGFA mRNA]
Gallic Acid results in decreased secretion of VEGFA protein

PMID:21420233 PMID:26530725

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

vasoactive intestinal peptide receptor 1

increases expression

ISO

Gallic Acid results in increased expression of VIPR1 mRNA

NCBI chr 8:130,181,219...130,217,098
Ensembl chr 8:130,187,731...130,217,096

G

von Willebrand factor A domain containing 5A

decreases expression

ISO

Gallic Acid results in decreased expression of VWA5A mRNA

NCBI chr 8:47,712,352...47,745,847
Ensembl chr 8:47,712,369...47,736,307

G

tryptophanyl-tRNA synthetase 1

increases expression

ISO

Gallic Acid results in increased expression of WARS1 mRNA

NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:133,539,744...133,571,645

G

WASP family member 1

increases expression
decreases expression

ISO

Gallic Acid results in increased expression of WASF1 mRNA
Gallic Acid results in decreased expression of WASF1 mRNA

NCBI chr20:45,908,458...45,956,118
Ensembl chr20:45,908,750...45,955,640

G

WASH complex subunit 2C

decreases expression

ISO

Gallic Acid results in decreased expression of WASHC2C mRNA

NCBI chr 4:150,912,863...150,998,301
Ensembl chr 4:150,912,395...150,998,301

G

WD repeat domain 25

decreases expression

ISO

Gallic Acid results in decreased expression of WDR25 mRNA

NCBI chr 6:133,571,790...133,704,154
Ensembl chr 6:133,571,804...133,704,145

G

WD repeat domain 81

increases expression

ISO

Gallic Acid results in increased expression of WDR81 mRNA

NCBI chr10:60,780,268...60,793,671
Ensembl chr10:60,780,268...60,793,592

G

WNK lysine deficient protein kinase 2

decreases expression

ISO

Gallic Acid results in decreased expression of WNK2 mRNA

NCBI chr17:15,709,648...15,818,874
Ensembl chr17:15,710,657...15,818,869

G

xanthine dehydrogenase

multiple interactions

EXP

Gallic Acid inhibits the reaction [Zearalenone results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-linked inhibitor of apoptosis

multiple interactions

ISO

Gallic Acid inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:125,737,971...125,803,978

G

X-prolyl aminopeptidase 1

increases expression

ISO

Gallic Acid results in increased expression of XPNPEP1 mRNA

NCBI chr 1:262,006,761...262,057,479
Ensembl chr 1:262,006,761...262,092,425

G

X-ray repair cross complementing 4

decreases expression

ISO

Gallic Acid results in decreased expression of XRCC4 mRNA

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

G

ybeY metalloendoribonuclease

decreases expression

ISO

Gallic Acid results in decreased expression of YBEY mRNA

NCBI chr20:12,164,678...12,175,150
Ensembl chr20:12,164,723...12,174,199

G

zinc finger CCCH type containing 12C

increases expression

ISO

Gallic Acid results in increased expression of ZC3H12C mRNA

NCBI chr 8:61,340,446...61,404,932
Ensembl chr 8:61,345,271...61,400,610

G

zinc finger, C3HC-type containing 1

increases expression

ISO

Gallic Acid results in increased expression of ZC3HC1 mRNA

NCBI chr 4:59,957,402...59,979,336
Ensembl chr 4:59,957,402...59,979,336

G

zinc finger protein 13

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF205 mRNA

NCBI chr10:13,119,707...13,128,284
Ensembl chr10:13,120,084...13,128,243

G

zinc finger protein 286A

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF286A mRNA

NCBI chr10:47,949,698...47,960,496
Ensembl chr10:47,949,699...47,960,606

G

zinc finger protein 329

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF329 mRNA

NCBI chr 1:82,469,019...82,570,542
Ensembl chr 1:82,430,646...82,570,552

G

zinc finger protein 612

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF23 mRNA

NCBI chr19:54,963,400...54,976,888
Ensembl chr19:54,963,379...54,977,075

G

zinc finger protein 62

decreases expression

ISO

Gallic Acid results in decreased expression of ZFP62 mRNA

NCBI chr10:34,019,367...34,040,564
Ensembl chr10:33,971,943...34,054,637

G

zinc finger protein 68

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF84 mRNA

NCBI chr12:21,139,838...21,154,775
Ensembl chr12:21,139,868...21,154,769

G

zinc finger protein 771

increases expression

ISO

Gallic Acid results in increased expression of ZNF771 mRNA

NCBI chr 1:191,294,530...191,305,629
Ensembl chr 1:191,294,530...191,306,215

G

zinc finger protein 821

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF821 mRNA

NCBI chr19:54,589,449...54,608,341
Ensembl chr19:54,590,152...54,608,340

G

zinc finger protein 827

decreases expression

ISO

Gallic Acid results in decreased expression of ZNF827 mRNA

NCBI chr19:45,624,849...45,791,739
Ensembl chr19:45,614,604...45,844,430

G

zinc finger FYVE-type containing 27

increases expression

ISO

Gallic Acid results in increased expression of ZFYVE27 mRNA

NCBI chr 1:250,929,110...250,952,481
Ensembl chr 1:250,928,012...250,952,481

G

zinc finger with KRAB and SCAN domains 1

increases expression

ISO

Gallic Acid results in increased expression of ZKSCAN1 mRNA

NCBI chr12:22,080,319...22,101,389
Ensembl chr12:22,080,324...22,101,387

G

zinc finger MYM-type containing 3

decreases expression

ISO

Gallic Acid results in decreased expression of ZMYM3 mRNA

NCBI chr X:70,568,573...70,584,221
Ensembl chr X:70,568,573...70,584,768

G

zinc finger, MYND-type containing 8

decreases expression

ISO

Gallic Acid results in decreased expression of ZMYND8 mRNA

NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:174,948,537...175,061,571

G

zinc finger, NFX1-type containing 1

decreases expression

ISO

Gallic Acid results in decreased expression of ZNFX1 mRNA

NCBI chr 3:176,183,111...176,210,812
Ensembl chr 3:176,183,135...176,243,685

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

ferritin light chain 1

decreases expression

ISO

ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

transferrin receptor

increases expression

ISO

ginkgetin results in increased expression of TFRC protein

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

tyrosine hydroxylase

multiple interactions

ISO

ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

increases expression

ISO

licofelone results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

Masoprocol binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

Masoprocol results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

ALK receptor tyrosine kinase

multiple interactions
decreases activity

ISO

Masoprocol affects the phosphorylation of and affects the activity of ALK protein mutant form
Masoprocol results in decreased activity of ALK protein

NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:28,632,197...29,349,721

G

arachidonate 12-lipoxygenase, 12S type

multiple interactions
decreases activity

ISO
EXP

Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
Masoprocol results in decreased activity of ALOX12 protein

PMID:3928952 PMID:6240459 PMID:9258337 PMID:17027136 PMID:23238474

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:55,456,928...55,469,199

G

arachidonate 15-lipoxygenase

multiple interactions
decreases activity

EXP
ISO

Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]
Masoprocol results in decreased activity of ALOX15 protein
[Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid

PMID:15574791 PMID:18984061

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

arachidonate 5-lipoxygenase

affects response to substance
decreases activity
multiple interactions

ISO
EXP

ALOX5 protein affects the susceptibility to Masoprocol
Masoprocol results in decreased activity of ALOX5 protein
Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]
[Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]

PMID:2724698 PMID:2849922 PMID:3928952 PMID:6240459 PMID:10698703 More...

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

androgen receptor

affects binding

EXP

Masoprocol binds to AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO

Masoprocol results in increased expression of BAX protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BH3 interacting domain death agonist

multiple interactions

ISO

[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

caspase 3

increases cleavage
multiple interactions
increases activity

ISO
EXP

Masoprocol results in increased cleavage of CASP3 protein
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased cleavage of and results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Masoprocol results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein

PMID:10203695 PMID:10653524 PMID:11470254 PMID:15034932 PMID:17645780 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions
increases expression

ISO

[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol results in increased expression of CASP8 protein

PMID:10203695 PMID:17645780

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases activity

ISO

Masoprocol results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

C-C motif chemokine ligand 5

multiple interactions

EXP

Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin D1

decreases expression

ISO

Masoprocol results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cadherin 1

decreases methylation
increases expression

ISO

Masoprocol results in decreased methylation of CDH1 promoter
Masoprocol results in increased expression of CDH1 mRNA; Masoprocol results in increased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase inhibitor 2A

decreases methylation
increases expression

ISO

Masoprocol results in decreased methylation of CDKN2A promoter
Masoprocol results in increased expression of CDKN2A mRNA; Masoprocol results in increased expression of CDKN2A protein

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

crystallin, alpha B

multiple interactions

EXP

Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB mRNA]; Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB protein]

NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528

G

iodothyronine deiodinase 1

decreases activity

ISO

Masoprocol results in decreased activity of DIO1 protein

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

iodothyronine deiodinase 2

decreases activity

ISO

Masoprocol results in decreased activity of DIO2 protein

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

iodothyronine deiodinase 3

decreases activity

ISO

Masoprocol results in decreased activity of DIO3 protein

NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:135,107,074...135,107,985

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

ISO

Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

estrogen receptor 1

multiple interactions

ISO

Masoprocol binds to and results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

Fas cell surface death receptor

increases expression

ISO

Masoprocol results in increased expression of FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions

ISO
EXP

Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of FASLG protein]

PMID:10203695 PMID:17651887

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

fibronectin 1

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein]

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

formyl peptide receptor 1

decreases activity

ISO

Masoprocol results in decreased activity of FPR1 protein

NCBI chr 1:67,417,991...67,429,813
Ensembl chr 1:67,421,313...67,422,520

G

heme oxygenase 1

increases expression

EXP
ISO

Masoprocol results in increased expression of HMOX1 mRNA; Masoprocol results in increased expression of HMOX1 protein

PMID:18852027 PMID:23942037

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases expression
increases activity

ISO

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]; [Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; Masoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]; Masoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein]

PMID:10377029 PMID:18032417

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

insulin-like growth factor 1

multiple interactions

ISO

Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]

PMID:18491370 PMID:18645000

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

multiple interactions
decreases activity

ISO

Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]; Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]; Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]
Masoprocol results in decreased activity of IGF1R protein

PMID:18491370 PMID:18645000

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

interleukin 1 beta

multiple interactions
decreases response to substance

ISO

Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Masoprocol results in decreased susceptibility to IL1B protein
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:8186192 PMID:12573452 PMID:21211511

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

iodotyrosine deiodinase

multiple interactions

ISO

Masoprocol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:42,410,099...42,425,414
Ensembl chr 1:42,410,130...42,426,386

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

ISO

Masoprocol results in decreased expression of JUN mRNA
Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]

PMID:10692565 PMID:15034932

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

potassium voltage-gated channel subfamily A member 5

multiple interactions

EXP

Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]

NCBI chr 4:161,040,853...161,044,311
Ensembl chr 4:160,996,950...161,044,408

G

keratin 1

multiple interactions

ISO

Masoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]

NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537

G

luteinizing hormone subunit beta

multiple interactions

EXP

Masoprocol inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Testosterone]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]
Masoprocol results in decreased phosphorylation of MAPK1 protein

PMID:17395008 PMID:19503098

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

ISO

Masoprocol results in decreased phosphorylation of MAPK3 protein
Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein]

PMID:17395008 PMID:19503098

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

matrix metallopeptidase 13

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]

PMID:17395008 PMID:21211511

NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

ISO

Masoprocol results in increased expression of MYC protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]; MYC affects the reaction [Masoprocol results in increased expression of MYC protein]; MYC affects the reaction [Masoprocol results in increased expression of TP53 protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NFE2 like bZIP transcription factor 2

multiple interactions

EXP

Masoprocol affects the localization of and results in increased activity of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nerve growth factor

multiple interactions

EXP

Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

nerve growth factor receptor

multiple interactions

EXP

Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein]

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

nitric oxide synthase 3

multiple interactions

ISO

Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

neuropeptide Y

multiple interactions

ISO

Masoprocol affects the reaction [bisphenol A affects the expression of NPY mRNA]

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310

G

ornithine decarboxylase 1

multiple interactions

ISO

Masoprocol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

ornithine transcarbamylase

multiple interactions

EXP

Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein]

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

proliferating cell nuclear antigen

multiple interactions

ISO

Masoprocol affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

prolactin

multiple interactions

EXP

Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein]

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

PMID:7575673 PMID:12573452

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RB transcriptional corepressor 1

decreases phosphorylation

ISO

Masoprocol results in decreased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sex hormone binding globulin

affects binding

ISO

Masoprocol binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

solute carrier family 5 member 5

multiple interactions

EXP

Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,580,705...18,590,691

G

superoxide dismutase 2

multiple interactions

ISO

Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]

PMID:8760145 PMID:12031898

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

Masoprocol results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

EXP

Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
decreases response to substance

ISO

Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
Masoprocol results in decreased susceptibility to TNF protein

PMID:8186192 PMID:8760145 PMID:21211511

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF superfamily member 10

multiple interactions

ISO

[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP10 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 2:112,136,550...112,155,903

G

tumor protein p53

multiple interactions
increases expression

ISO

MYC affects the reaction [Masoprocol results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

EXP

Masoprocol inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

thyroid stimulating hormone subunit beta

multiple interactions

EXP

Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA]

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

ISO

UGT1A1 protein results in increased glucuronidation of Masoprocol

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of Masoprocol

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

vascular endothelial growth factor A

multiple interactions

ISO

Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

meclofenamic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

decreases activity

ISO

Meclofenamic Acid results in decreased activity of AKR1C1 protein

PMID:19010312 PMID:26362498 PMID:27163852

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C2

decreases activity

ISO

Meclofenamic Acid results in decreased activity of AKR1C2 protein

PMID:19010312 PMID:26362498 PMID:27163852

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

Meclofenamic Acid results in decreased activity of AKR1C3 protein

PMID:19010312 PMID:26362498 PMID:27163852

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

arachidonate 5-lipoxygenase

decreases activity

ISO

Meclofenamic Acid results in decreased activity of ALOX5 protein

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

renin

multiple interactions

EXP

Meclofenamic Acid inhibits the reaction [Yohimbine results in increased expression of REN protein]

NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543

G

selectin L

decreases expression

ISO

Meclofenamic Acid results in decreased expression of SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

solute carrier family 16 member 2

multiple interactions

ISO

Meclofenamic Acid inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine]

NCBI chr X:72,791,096...72,914,299
Ensembl chr X:72,781,876...72,914,498

G

sulfotransferase family 1A member 1

decreases activity

ISO

Meclofenamic Acid results in decreased activity of SULT1A1 protein

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1E member 1

decreases activity

ISO

Meclofenamic Acid results in decreased activity of SULT1E1 protein

NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716

G

tumor necrosis factor

multiple interactions

ISO

Meclofenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

ISO

Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

ISO

silychristin results in increased expression of ABCA1 protein

NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:72,473,676...72,596,473

G

carbonic anhydrase 1

decreases activity

ISO

silychristin results in decreased activity of CA1 protein

NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454

G

carbonic anhydrase 2

decreases activity

ISO

silychristin results in decreased activity of CA2 protein

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

G

interferon gamma

multiple interactions

ISO

silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO

silychristin inhibits the reaction [IL1B protein results in increased expression of IFNG mRNA]; silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IFNG protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

multiple interactions

ISO

silychristin inhibits the reaction [IL1B protein results in increased secretion of IL2 protein]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

platelet factor 4

multiple interactions

ISO

silychristin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

tumor necrosis factor

multiple interactions

ISO

silychristin inhibits the reaction [IL1B protein results in increased expression of TNF mRNA]; silychristin inhibits the reaction [IL1B protein results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vasodilator-stimulated phosphoprotein

increases phosphorylation

ISO

silychristin results in increased phosphorylation of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

sodium benzoate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases activity
increases expression

EXP
ISO

Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased activity of ACHE protein]; Coconut Oil affects the reaction [Sodium Benzoate results in increased expression of ACHE mRNA]
Sodium Benzoate results in increased expression of ACHE protein

PMID:30154464 PMID:35187746 PMID:36265761 PMID:38243570

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

actin alpha 2, smooth muscle

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [arsenite results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adhesion G protein-coupled receptor E1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of ADGRE1 mRNA]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

aryl hydrocarbon receptor

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

allograft inflammatory factor 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of AIF1 mRNA]

NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339

G

alkaline phosphatase, biomineralization associated

decreases expression

EXP

Sodium Benzoate results in decreased expression of ALPL protein

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

androgen receptor

decreases expression
multiple interactions

EXP

Sodium Benzoate results in decreased expression of AR mRNA
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of AR mRNA]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

activating transcription factor 2

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ATF2 protein]

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:79,126,705...79,202,745

G

Bcl2-like 11

increases expression
multiple interactions

ISO

Sodium Benzoate results in increased expression of BCL2L11 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile affects the reaction [Sodium Benzoate results in increased expression of BCL2L11 protein]

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

EXP

Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]

NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504

G

caspase 3

multiple interactions
increases activity
increases expression

ISO
EXP

3-(4-methylphenylsulfonyl)-2-propenenitrile affects the reaction [Sodium Benzoate results in increased activity of CASP3 protein]; Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]
Sodium Benzoate results in increased expression of CASP3 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of CASP3 protein]

PMID:11329530 PMID:29565269 PMID:32911041 PMID:35187746 PMID:39106537

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

decreases expression
decreases activity
multiple interactions

EXP

Sodium Benzoate results in decreased expression of CAT protein
Sodium Benzoate results in decreased activity of CAT protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of CAT protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in decreased activity of CAT protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in decreased expression of CAT protein]

PMID:32911041 PMID:35187746 PMID:36265761 PMID:37045926 PMID:38243570 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CCL2 mRNA]
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

CD163 molecule

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CD163 mRNA]

NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:158,770,749...158,804,146

G

Cd80 molecule

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of CD80 mRNA]

NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540

G

ciliary neurotrophic factor

multiple interactions
increases expression

ISO

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Benzoate results in increased expression of CNTF protein]; Sodium Benzoate results in increased expression of and results in increased secretion of CNTF protein
CREB1 affects the reaction [Sodium Benzoate results in increased expression of CNTF protein]; Sodium Benzoate promotes the reaction [CREB1 protein binds to CNTF promoter]; Sodium Benzoate promotes the reaction [CREBBP protein binds to CNTF promoter]
Sodium Benzoate results in increased expression of CNTF mRNA

NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488

G

collagen type I alpha 1 chain

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

collagen type III alpha 1 chain

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [arsenite results in increased expression of COL3A1 protein]

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232

G

carbamoyl-phosphate synthase 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [arsenite results in increased expression of CPS1 protein]

NCBI chr 9:76,063,863...76,186,739
Ensembl chr 9:76,000,754...76,186,734

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation

ISO

CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]
Sodium Benzoate results in increased phosphorylation of CREB1 protein
CREB1 affects the reaction [Sodium Benzoate results in increased expression of CNTF protein]; CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]; CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Benzoate results in increased phosphorylation of CREB1 protein]; Sodium Benzoate promotes the reaction [CREB1 protein binds to CNTF promoter]

PMID:26399250 PMID:31119595 PMID:34113786

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

CREB binding protein

multiple interactions

ISO

Sodium Benzoate promotes the reaction [CREBBP protein binds to CNTF promoter]

NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,822,620...11,968,266

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 2, subfamily a, polypeptide 3

multiple interactions

ISO

Sodium Benzoate affects the reaction [Fructose affects the expression of CYP2A4 mRNA]

NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:91,299,561...91,307,649

G

D-amino-acid oxidase

multiple interactions
decreases activity

ISO
EXP

Sodium Benzoate inhibits the reaction [[DAO protein results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
Sodium Benzoate results in decreased activity of DAO protein

PMID:19860415 PMID:20952482 PMID:36849798

NCBI chr12:48,252,900...48,275,964
Ensembl chr12:48,252,902...48,273,300

G

estrogen receptor 1

decreases activity

ISO

Sodium Benzoate results in decreased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

forkhead box P3

increases expression
affects expression

ISO
EXP

Sodium Benzoate results in increased expression of FOXP3 mRNA
Sodium Benzoate affects the expression of FOXP3 mRNA

PMID:27605008 PMID:32534510

NCBI chr X:17,580,380...17,601,181
Ensembl chr X:17,580,380...17,595,894

G

follicle stimulating hormone subunit beta

increases expression

EXP

Sodium Benzoate results in increased expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
decreases expression

ISO

[Sodium Benzoate co-treated with Sorbic Acid] affects the expression of GADD45A mRNA
Sodium Benzoate results in decreased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

guanylate binding protein 4

multiple interactions

ISO

Sodium Benzoate affects the reaction [Fructose affects the expression of GBP3 mRNA]

NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120

G

glial cell derived neurotrophic factor

increases expression
multiple interactions

ISO

Sodium Benzoate results in increased expression of GDNF mRNA; Sodium Benzoate results in increased expression of GDNF protein
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of GDNF mRNA]; GDNF protein promotes the reaction [Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein]

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

glial fibrillary acidic protein

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutamic-oxaloacetic transaminase 1

increases expression

EXP

Sodium Benzoate results in increased expression of GOT1 protein

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases expression

EXP

Sodium Benzoate results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of GRIN1 protein]

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754

G

heme oxygenase 1

decreases expression
multiple interactions

EXP

Sodium Benzoate results in decreased expression of HMOX1 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

histamine N-methyltransferase

multiple interactions

ISO

HNMT gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with quinoline yellow co-treated with Allura Red AC Dye co-treated with Sodium Benzoate]; HNMT gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with Tartrazine co-treated with ponceau 4R co-treated with Sodium Benzoate]

NCBI chr 3:26,978,274...27,010,291
Ensembl chr 3:26,977,933...27,010,482

G

intercellular adhesion molecule 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions
affects expression

ISO
EXP

[Fructose co-treated with Sodium Benzoate] results in increased expression of IFNG protein; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]
Sodium Benzoate affects the expression of IFNG mRNA
[Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG mRNA; [Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG protein
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IFNG mRNA

PMID:26706697 PMID:27611715 PMID:32179172 PMID:32534510 PMID:39519554

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

multiple interactions
affects expression

EXP

[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL10 mRNA
Sodium Benzoate affects the expression of IL10 mRNA

PMID:32179172 PMID:32534510

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 17A

multiple interactions

ISO

[Fructose co-treated with Sodium Benzoate] results in increased expression of IL17A protein

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of IL1B mRNA]
Sodium Benzoate results in increased expression of IL1B protein
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL1B mRNA; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of IL1B protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in increased expression of IL1B protein]

PMID:32179172 PMID:36265761 PMID:36849798 PMID:38243570 PMID:39106537

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2 receptor subunit alpha

increases expression

ISO

Sodium Benzoate results in increased expression of IL2RA mRNA

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 4

multiple interactions

ISO

[Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 mRNA; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
increases expression

ISO
EXP

Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of IL6 mRNA
Sodium Benzoate results in increased expression of IL6 protein

PMID:26706697 PMID:32179172 PMID:32911041

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of JUN protein]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lipocalin 2

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of LCN2 mRNA]

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

lactate dehydrogenase A

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

luteinizing hormone subunit beta

increases expression

EXP

Sodium Benzoate results in increased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

mitogen activated protein kinase 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions
decreases expression

ISO

[Sodium Benzoate co-treated with Sorbic Acid] results in increased expression of MAPK8 mRNA; Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of MAPK8 protein]; Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased phosphorylation of MAPK8 protein]
Sodium Benzoate results in decreased expression of MAPK8 mRNA
Sodium Benzoate promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

PMID:28229641 PMID:32781134 PMID:36849798

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

myelin basic protein

multiple interactions

ISO

[Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG mRNA; [Sodium Benzoate co-treated with MBP protein] results in decreased expression of IFNG protein; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 mRNA; [Sodium Benzoate co-treated with MBP protein] results in increased expression of IL4 protein

NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174

G

mannose receptor, C type 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of MRC1 mRNA]

NCBI chr17:82,157,725...82,239,411
Ensembl chr17:82,157,705...82,239,410

G

macrophage scavenger receptor 1

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA alternative form]; Sodium Benzoate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]

NCBI chr16:59,421,250...59,507,070
Ensembl chr16:59,421,057...59,507,070

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

EXP

Sodium Benzoate results in decreased expression of NFE2L2 mRNA; Sodium Benzoate results in decreased expression of NFE2L2 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 mRNA]; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 protein]; Coconut Oil inhibits the reaction [Sodium Benzoate results in decreased expression of NFE2L2 mRNA]

PMID:36265761 PMID:38243570 PMID:39106537

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

EXP

Sodium Benzoate results in increased expression of NFKB1 mRNA; Sodium Benzoate results in increased expression of NFKB1 protein
[Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of NFKB1 protein]; Coconut Oil affects the reaction [Sodium Benzoate results in increased expression of NFKB1 mRNA]

PMID:37045926 PMID:38243570 PMID:39106537

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nitric oxide synthase 2

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

5' nucleotidase, ecto

increases expression

ISO

Sodium Benzoate results in increased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

ornithine transcarbamylase

multiple interactions

ISO

Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Glycine]; Sodium Benzoate affects the reaction [OTC gene mutant form affects the metabolism of Serotonin]; Sodium Benzoate affects the reaction [OTC gene mutant form results in increased abundance of Ammonium Compounds]

PMID:3091026 PMID:3374991

NCBI chr X:15,126,358...15,202,473
Ensembl chr X:15,126,358...15,239,555

G

phospholipase A2, group XV

increases expression

ISO

Sodium Benzoate results in increased expression of PLA2G15 protein

NCBI chr19:50,960,568...50,977,948
Ensembl chr19:50,960,598...50,977,946

G

phospholipase A2 group IVC

increases expression

ISO

Sodium Benzoate results in increased expression of PLA2G4C protein

NCBI chr 1:83,315,017...83,411,342
Ensembl chr 1:83,382,068...83,410,037

G

prostaglandin-endoperoxide synthase 2

increases expression

ISO

Sodium Benzoate results in increased expression of PTGS2 protein

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased phosphorylation of RELA protein]
Sodium Benzoate affects the localization of RELA protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Sodium Benzoate affects the localization of RELA protein]

PMID:29565269 PMID:36849798

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [Adenine results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [Adenine results in increased expression of RELB protein]
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of RELB protein]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of RELB mRNA]

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

selectin L

increases expression

ISO

Sodium Benzoate results in increased expression of SELL mRNA

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600

G

solute carrier family 6 member 3

multiple interactions

ISO

SLC6A3 gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with quinoline yellow co-treated with Allura Red AC Dye co-treated with Sodium Benzoate]; SLC6A3 gene SNP affects the susceptibility to [6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with azo rubin S co-treated with Tartrazine co-treated with ponceau 4R co-treated with Sodium Benzoate]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

superoxide dismutase 1

decreases expression

EXP

Sodium Benzoate results in decreased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

signal transducer and activator of transcription 6

multiple interactions

ISO

Sodium Benzoate promotes the reaction [STAT6 protein binds to TGFB1 promoter]; Sodium Benzoate results in increased phosphorylation of and affects the localization of STAT6 protein

NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795

G

T-box transcription factor 21

affects expression

EXP

Sodium Benzoate affects the expression of TBX21 mRNA

NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,578,751...82,595,253

G

transcription factor A, mitochondrial

increases expression

EXP

Sodium Benzoate results in increased expression of TFAM protein

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

transforming growth factor, beta 1

increases expression
affects expression
multiple interactions

ISO
EXP

Sodium Benzoate results in increased expression of TGFB1 mRNA
Sodium Benzoate affects the expression of TGFB1 mRNA
Sodium Benzoate inhibits the reaction [Adenine results in increased expression of TGFB1 mRNA]; Sodium Benzoate promotes the reaction [STAT6 protein binds to TGFB1 promoter]; Sodium Benzoate results in increased expression of and results in increased secretion of TGFB1 protein

PMID:27605008 PMID:32534510 PMID:36849798

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

increases expression
multiple interactions

ISO

Sodium Benzoate results in increased expression of TH mRNA; Sodium Benzoate results in increased expression of TH protein
CREB1 protein promotes the reaction [Sodium Benzoate results in increased expression of TH protein]; GDNF protein promotes the reaction [Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Sodium Benzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]

PMID:31119595 PMID:34113786

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

toll-like receptor 2

increases expression

EXP

Sodium Benzoate results in increased expression of TLR2 mRNA

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

increases expression

EXP

Sodium Benzoate results in increased expression of TLR4 mRNA

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions
affects expression
increases expression

ISO
EXP

[Fructose co-treated with Sodium Benzoate] results in increased expression of TNF protein; Sodium Benzoate inhibits the reaction [Adenine results in increased expression of TNF mRNA]; Sodium Benzoate inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TNF protein]; Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Sodium Benzoate affects the expression of TNF mRNA
Sodium Benzoate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of RELB mRNA]; Sodium Benzoate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
[Food Preservatives results in increased abundance of Sodium Benzoate] which results in increased expression of TNF mRNA; [Zinc Sulfate results in increased abundance of Zinc] inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]; Ascorbic Acid inhibits the reaction [Sodium Benzoate results in increased expression of TNF protein]
Sodium Benzoate results in increased expression of TNF mRNA; Sodium Benzoate results in increased expression of TNF protein

PMID:26706697 PMID:32179172 PMID:32534510 PMID:32781134 PMID:32911041 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO
EXP

Sodium Benzoate inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]
Sodium Benzoate results in increased expression of TP53 protein

PMID:16357363 PMID:32911041

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

uncoupling protein 2

increases expression

EXP

Sodium Benzoate results in increased expression of UCP2 protein

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

vimentin

multiple interactions

ISO

Sodium Benzoate inhibits the reaction [arsenite results in increased expression of VIM protein]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

xanthine dehydrogenase

increases activity

EXP

Sodium Benzoate results in increased activity of XDH protein

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

sulindac sulfone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B1

multiple interactions

ISO

sulindac sulfone binds to and results in decreased activity of AKR1B1 protein

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315

G

aldo-keto reductase family 1 member B10

multiple interactions

ISO

sulindac sulfone binds to and results in decreased activity of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

AKT serine/threonine kinase 1

affects phosphorylation
multiple interactions

ISO
EXP

sulindac sulfone affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form

PMID:15570007 PMID:17908994

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

arachidonate 15-lipoxygenase

multiple interactions
increases expression

ISO

8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]; GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in increased expression of ALOX15 mRNA; sulindac sulfone results in increased expression of ALOX15 protein

PMID:11861401 PMID:16166323

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

androgen receptor

multiple interactions

ISO
EXP

AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]; sulindac sulfone results in decreased expression of and results in decreased activity of AR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein

PMID:14581372 PMID:17908994

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2-antagonist/killer 1

increases response to substance

EXP

BAK1 results in increased susceptibility to sulindac sulfone

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

caspase 3

multiple interactions
increases activity

ISO

MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]; sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein
sulindac sulfone results in increased activity of CASP3 protein

PMID:11051267 PMID:14555707 PMID:15548677

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases activity

ISO

sulindac sulfone results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

cyclin D1

decreases expression
multiple interactions

ISO
EXP

sulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein

PMID:12392815 PMID:15188006 PMID:17908994

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

sulindac sulfone results in increased expression of CDKN1A mRNA; sulindac sulfone results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

sulindac sulfone results in increased expression of CDKN1B mRNA; sulindac sulfone results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

catenin beta 1

multiple interactions
increases expression
decreases expression

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]
sulindac sulfone results in increased expression of CTNNB1 protein

PMID:10910034 PMID:11602670 PMID:12392815 PMID:14555707

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

epidermal growth factor receptor

multiple interactions
increases ubiquitination
increases phosphorylation
decreases phosphorylation
decreases expression

ISO
EXP

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]
sulindac sulfone results in increased ubiquitination of EGFR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form
sulindac sulfone results in increased phosphorylation of EGFR protein
sulindac sulfone results in decreased phosphorylation of EGFR protein

PMID:17908994 PMID:20332299

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

erb-b2 receptor tyrosine kinase 2

decreases expression

ISO

sulindac sulfone results in decreased expression of ERBB2 protein

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481

G

erb-b2 receptor tyrosine kinase 3

multiple interactions
decreases expression

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein]

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120

G

estrogen receptor 1

decreases expression

ISO

sulindac sulfone results in decreased expression of ESR1 mRNA; sulindac sulfone results in decreased expression of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

GATA binding protein 6

multiple interactions
decreases expression

ISO

GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in decreased expression of GATA6 protein

NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322

G

glutathione S-transferase pi 1

multiple interactions

ISO

sulindac sulfone binds to and results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

histidine triad nucleotide binding protein 1

increases expression

ISO

sulindac sulfone results in increased expression of HINT1 mRNA; sulindac sulfone results in increased expression of HINT1 protein

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642

G

15-hydroxyprostaglandin dehydrogenase

increases activity
increases expression

ISO

sulindac sulfone results in increased activity of HPGD protein
sulindac sulfone results in increased expression of HPGD mRNA

NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831

G

interleukin 24

increases expression

ISO

sulindac sulfone results in increased expression of IL24 protein

NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760

G

kallikrein 1-related peptidase C10

multiple interactions
decreases expression

ISO

AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]

PMID:11490238 PMID:14581372

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184

G

mitogen activated protein kinase kinase 4

multiple interactions

ISO

sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein

NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

ISO

MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

ISO

MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases activity

ISO

sulindac sulfone results in increased activity of MAPK8 protein

PMID:11051267 PMID:11278263 PMID:15970671

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

matrix metallopeptidase 7

decreases expression

ISO

sulindac sulfone results in decreased expression of MMP7 protein

NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755

G

NFKB inhibitor alpha

multiple interactions

ISO

sulindac sulfone results in increased degradation of and results in decreased expression of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nerve growth factor receptor

increases expression

ISO

sulindac sulfone results in increased expression of NGFR mRNA; sulindac sulfone results in increased expression of NGFR protein

NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

ISO

sulindac sulfone results in increased activity of NQO1 protein
sulindac sulfone results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

proliferating cell nuclear antigen

decreases expression

ISO

sulindac sulfone results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphodiesterase 2A

decreases activity
multiple interactions

ISO

sulindac sulfone results in decreased activity of PDE2A protein
sulindac sulfone binds to and results in decreased activity of PDE2A protein

PMID:10910034 PMID:11602670

NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466

G

phosphodiesterase 5A

multiple interactions
decreases activity

ISO

sulindac sulfone binds to and results in decreased activity of PDE5A protein
sulindac sulfone results in decreased activity of PDE5A protein

PMID:10910034 PMID:11602670

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

progesterone receptor

decreases expression

ISO

sulindac sulfone results in decreased expression of PGR mRNA; sulindac sulfone results in decreased expression of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

sulindac sulfone results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

increases expression

ISO

sulindac sulfone results in increased expression of PPARD mRNA

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

ISO

[sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]
sulindac sulfone results in increased expression of PPARG mRNA

PMID:11948457 PMID:14506281

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein kinase cGMP-dependent 1

increases expression

ISO

sulindac sulfone results in increased expression of PRKG1 protein

PMID:11602670 PMID:16731751

NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005

G

prostate stem cell antigen

increases expression

ISO

sulindac sulfone results in increased expression of PSCA mRNA

NCBI chr 7:108,483,974...108,492,098
Ensembl chr 7:108,484,184...108,492,097

G

prostaglandin-endoperoxide synthase 1

decreases expression

EXP

sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions
increases expression

ISO
EXP

sulindac sulfone results in decreased expression of PTGS2 protein
sulindac sulfone results in decreased expression of PTGS2 mRNA
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]
[sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
sulindac sulfone results in increased expression of PTGS2 mRNA

PMID:11118042 PMID:11375891 PMID:11948457 PMID:17908994

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

affects localization

ISO

sulindac sulfone affects the localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

spermidine/spermine N1-acetyl transferase 1

multiple interactions
increases expression

ISO

[sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]

PMID:14506281 PMID:16262603

NCBI chr X:44,008,089...44,011,376
Ensembl chr X:44,006,781...44,011,374

G

tumor necrosis factor

multiple interactions

EXP

Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

UDP glucuronosyltransferase family 1 member A1

increases activity
increases glucuronidation
increases expression

ISO

sulindac sulfone results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of sulindac sulfone
sulindac sulfone results in increased expression of UGT1A1 mRNA

PMID:15843492 PMID:17985343

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

ISO

UGT1A3 protein results in increased glucuronidation of sulindac sulfone

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A5

increases glucuronidation

ISO

UGT1A4 protein results in increased glucuronidation of sulindac sulfone

NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation

ISO

UGT2B7 protein results in increased glucuronidation of sulindac sulfone

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

G

vasodilator-stimulated phosphoprotein

increases phosphorylation

ISO

sulindac sulfone results in increased phosphorylation of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreases expression

ISO

sulindac sulfone results in decreased expression of YWHAE protein

NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

decreases activity
multiple interactions

ISO
EXP

tepoxalin results in decreased activity of ALOX5 protein
[tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]

PMID:9223651 PMID:12629151

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

intercellular adhesion molecule 1

multiple interactions

ISO

tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 6

multiple interactions

ISO

tepoxalin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha M

multiple interactions

ISO

tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

selectin E

multiple interactions

ISO

tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of SELE mRNA]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

trans-caffeic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

caffeic acid results in increased phosphorylation of and results in decreased activity of ACACA protein

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acetylcholinesterase

multiple interactions
decreases activity

EXP

caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

ATP citrate lyase

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein

NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631

G

arachidonate 15-lipoxygenase

decreases activity
multiple interactions

ISO

caffeic acid results in decreased activity of ALOX15 protein
[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein]

PMID:10904086 PMID:11406566 PMID:15574791

NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723

G

arachidonate 5-lipoxygenase

multiple interactions

ISO
EXP

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of ALOX5 protein]
caffeic acid inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]; caffeic acid inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein]

PMID:18482095 PMID:18951527 PMID:27368151

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

amyloid beta precursor protein

multiple interactions

ISO

caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form]; caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

arginase 1

decreases activity

ISO

caffeic acid results in decreased activity of ARG1 protein

NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:22,295,322...22,307,713

G

ATPase H+ transporting V0 subunit D2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

caspase 3

multiple interactions

ISO
EXP

[caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of CASP3 protein]

PMID:15574791 PMID:29968957

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

multiple interactions
increases activity

ISO
EXP

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [CAT protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
caffeic acid results in increased activity of CAT protein
caffeic acid inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; caffeic acid inhibits the reaction [Nickel results in decreased activity of CAT protein]

PMID:18405891 PMID:21640567 PMID:22036979 PMID:27378625

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

[Resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL2 mRNA; caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:16806235 PMID:31306686

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 4

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL4 mRNA

NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,950,289...68,965,722

G

C-C motif chemokine receptor 1

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR1 mRNA

NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374

G

C-C motif chemokine receptor 2

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059

G

C-C motif chemokine receptor 4

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCR4 mRNA

NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642

G

Cd4 molecule

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA

NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461

G

Cd68 molecule

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD68 mRNA

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,880,563...54,882,540

G

cell division cycle 20

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA

NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:137,251,596...137,255,799

G

cyclin dependent kinase 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

choline O-acetyltransferase

multiple interactions

ISO

caffeic acid inhibits the reaction [aluminum chloride results in decreased expression of CHAT protein]

NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416

G

catechol-O-methyltransferase

increases methylation

ISO

COMT protein results in increased methylation of caffeic acid

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533

G

corticotropin releasing hormone

multiple interactions

EXP

caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]

NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386

G

cardiotrophin 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:191,757,477...191,776,395

G

cathepsin B

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol affects the activity of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

death-associated protein

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]

NCBI chr 2:83,910,113...83,962,673
Ensembl chr 2:83,910,060...83,962,673

G

DnaJ heat shock protein family (Hsp40) member B11

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]

NCBI chr11:91,656,334...91,672,800
Ensembl chr11:91,656,335...91,672,800

G

dihydropyrimidinase-like 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]

NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:203,311,694...203,328,523

G

endothelin 1

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687

G

early growth response 1

multiple interactions

ISO

caffeic acid affects the reaction [Acetaminophen results in increased expression of and affects the localization of EGR1 protein]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of EGR1 mRNA]

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

engulfment and cell motility 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]

NCBI chr 3:174,442,965...174,716,723
Ensembl chr 3:174,442,965...174,480,459

G

Ets2 repressor factor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]

NCBI chr 1:89,957,760...89,966,213
Ensembl chr 1:89,957,760...89,966,213

G

coagulation factor III, tissue factor

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of F3 protein]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid synthase

decreases expression
multiple interactions

ISO

caffeic acid results in decreased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein

PMID:21870829 PMID:28576465

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibronectin leucine rich transmembrane protein 2

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]

NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:120,507,689...120,609,004

G

Fms related receptor tyrosine kinase 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]

NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645

G

glucose-6-phosphate dehydrogenase

decreases activity

ISO

caffeic acid results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A mRNA]; caffeic acid inhibits the reaction [Acetaminophen results in increased expression of GADD45A protein]

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

galactosidase, beta 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol affects the activity of GLB1 protein]

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

glutaminase

increases expression

ISO

caffeic acid results in increased expression of GLS protein

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

glutamic-oxaloacetic transaminase 1

multiple interactions

EXP

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased activity of GPT protein]

PMID:15212457 PMID:27720869

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]

PMID:19442820 PMID:21640567 PMID:22036979

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase mu 1

decreases activity

EXP

caffeic acid results in decreased activity of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

decreases activity

EXP

caffeic acid results in decreased activity of GSTM2 protein

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase pi 1

decreases activity

EXP

caffeic acid results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glucuronidase, beta

multiple interactions

EXP

caffeic acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

EXP

caffeic acid inhibits the reaction [Cisplatin results in decreased activity of H6PD protein]

NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:165,721,654...165,753,125

G

hepatitis A virus cellular receptor 2

multiple interactions

ISO

[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of HAVCR2 mRNA

NCBI chr10:31,383,801...31,415,334
Ensembl chr10:31,383,925...31,413,872

G

hes family bHLH transcription factor 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of HES1 mRNA]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:84,210,633...84,213,061

G

holocarboxylase synthetase

decreases activity

ISO

caffeic acid results in decreased activity of HLCS protein

NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

ISO

caffeic acid results in decreased expression of HMGCR mRNA

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heat shock protein 90 beta family member 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]

NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293

G

heat shock protein family E (Hsp10) member 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA]

NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502

G

interferon gamma

increases expression
multiple interactions

ISO
EXP

caffeic acid results in increased expression of IFNG protein
caffeic acid inhibits the reaction [Valproic Acid results in increased expression of IFNG protein]

PMID:27378625 PMID:29968957

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 10

decreases expression

ISO

caffeic acid results in decreased expression of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO
EXP

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]

PMID:27368151 PMID:27720869

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 2

increases expression

ISO

caffeic acid results in increased expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 21 receptor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA]

NCBI chr 1:189,598,682...189,626,340
Ensembl chr 1:189,598,558...189,626,342

G

interleukin 4

decreases expression

ISO

caffeic acid results in decreased expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

increases expression
multiple interactions

ISO
EXP

caffeic acid results in increased expression of IL6 mRNA
caffeic acid inhibits the reaction [Bleomycin results in increased secretion of IL6 protein]
caffeic acid inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]

PMID:21870829 PMID:27368151 PMID:27720869 PMID:28299617

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinesin family member 15

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA

NCBI chr 8:131,479,340...131,550,209
Ensembl chr 8:131,479,337...131,550,202

G

kinesin family member 20B

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA]

NCBI chr 1:241,840,898...241,896,451
Ensembl chr 1:241,840,987...241,896,451

G

kinesin family member 2C

multiple interactions

ISO

caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA]

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

monoamine oxidase A

decreases activity

ISO

caffeic acid results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

monoamine oxidase B

decreases activity

ISO

caffeic acid results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

mitogen activated protein kinase kinase 5

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373

G

mitogen activated protein kinase 1

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitofusin 1

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA]

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:117,241,759...117,290,190

G

microsomal glutathione S-transferase 1

increases activity

EXP

caffeic acid results in increased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [MPO protein results in increased metabolism of Hydrogen Peroxide]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [caffeic acid inhibits the reaction [Ethanol results in increased activity of MPO protein]]
caffeic acid results in decreased activity of MPO protein

PMID:22036979 PMID:24060682 PMID:33301711

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mitochondrial ribosomal protein L45

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA]

NCBI chr10:82,805,039...82,816,862
Ensembl chr10:82,804,874...82,816,139

G

mitochondrial ribosome recycling factor

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA]

NCBI chr 3:39,884,530...39,941,317
Ensembl chr 3:39,884,359...39,967,397

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions

ISO

[caffeic acid co-treated with Zymosan] results in increased expression of COX2 protein; caffeic acid inhibits the reaction [Zymosan results in increased expression of COX2 protein]

NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674

G

norrin cystine knot growth factor NDP

increases expression

ISO

caffeic acid results in increased expression of NDP mRNA

NCBI chr X:8,379,569...8,404,019
Ensembl chr X:8,379,569...8,406,802

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]
caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:29968957 PMID:31306686

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

ISO

caffeic acid results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

notch receptor 1

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of NOTCH1 mRNA]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613

G

5' nucleotidase, ecto

multiple interactions
decreases activity

EXP

caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]

NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645

G

programmed cell death 10

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA]

NCBI chr 2:162,602,516...162,644,690
Ensembl chr 2:162,602,516...162,644,612

G

phosphogluconate dehydrogenase

decreases activity

ISO

caffeic acid results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

ISO

caffeic acid results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

polo-like kinase 1

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA

NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:186,147,658...186,157,637

G

polo-like kinase 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA]

NCBI chr 2:125,730,480...125,748,894
Ensembl chr 2:125,730,460...125,748,892

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

caffeic acid results in increased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

peroxiredoxin 5

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA]

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:213,529,035...213,533,020

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA]

PMID:19442820 PMID:22036979 PMID:31306686

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

pentraxin 3

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA]

NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

caffeic acid inhibits the reaction [Valproic Acid results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

stearoyl-CoA desaturase

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

serpin family E member 1

multiple interactions

ISO

caffeic acid inhibits the reaction [Acetaminophen results in increased expression of SERPINE1 protein]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sideroflexin 4

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA]

NCBI chr 1:269,962,527...269,984,849
Ensembl chr 1:269,962,535...269,984,836

G

solute carrier family 2 member 2

increases expression

ISO

caffeic acid results in increased expression of SLC2A2 mRNA

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 4

increases expression

ISO

caffeic acid results in increased expression of SLC2A4 mRNA

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 5 member 1

increases expression

ISO

caffeic acid results in increased expression of SLC5A1 mRNA

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

synuclein alpha

multiple interactions

ISO

caffeic acid inhibits the reaction [SNCA protein binds to SNCA protein]

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

serine/threonine kinase 32A

multiple interactions

ISO

[Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA

NCBI chr18:35,509,791...35,620,421
Ensembl chr18:35,509,982...35,628,985

G

sulfotransferase family 1A member 1

increases sulfation

ISO

SULT1A1 protein results in increased sulfation of caffeic acid

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

sulfotransferase family 1C member 2A

increases sulfation

ISO

SULT1C2 protein results in increased sulfation of caffeic acid

NCBI chr 9:7,075,873...7,103,316
Ensembl chr 9:7,066,905...7,244,132

G

tumor necrosis factor

multiple interactions
increases expression

ISO
EXP

caffeic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]
caffeic acid results in increased expression of TNF mRNA

PMID:21870829 PMID:22036979 PMID:27368151 PMID:29968957 PMID:31306686

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

affects expression
multiple interactions

ISO

caffeic acid affects the expression of TP53 protein
caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA]

PMID:11522280 PMID:19442820

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tyrosinase

increases oxidation
multiple interactions

ISO

TYR protein results in increased oxidation of caffeic acid
[TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857

G

ubiquitin-conjugating enzyme E2C

multiple interactions

ISO

caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA]

NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:173,925,934...173,932,678

G

UDP glucuronosyltransferase family 1 member A1

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A1 protein

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation
decreases activity

ISO

UGT1A3 protein results in increased glucuronidation of caffeic acid
caffeic acid results in decreased activity of UGT1A3 protein

PMID:15117964 PMID:35868516

NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A6a

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A6 protein

NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

decreases activity

ISO

caffeic acid results in decreased activity of UGT1A9 protein

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase 2 family, polypeptide B1

decreases activity

ISO

caffeic acid results in decreased activity of UGT2B17 protein

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

UDP glucuronosyltransferase family 2 member B7

decreases activity

ISO

caffeic acid results in decreased activity of UGT2B7 protein

NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451

G

vascular endothelial growth factor A

decreases secretion

ISO

caffeic acid results in decreased secretion of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

xanthine dehydrogenase

multiple interactions

ISO

caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

affects response to substance

ISO

ABCC1 gene SNP affects the susceptibility to zileuton

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

actin alpha 2, smooth muscle

multiple interactions

ISO

zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

albumin

multiple interactions

ISO

zileuton metabolite binds to and results in increased alkylation of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

arachidonate 5-lipoxygenase

affects response to substance
decreases expression
multiple interactions
decreases activity

ISO
EXP

ALOX5 gene SNP affects the susceptibility to zileuton
zileuton results in decreased expression of ALOX5 mRNA
[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; zileuton binds to and results in decreased activity of ALOX5 protein; zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]; zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA]
[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [L 708714 binds to ALOX5 protein]

PMID:1781415 PMID:7577949 PMID:7592874 PMID:7665580 PMID:7812673 More...

NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126

G

caspase 3

multiple interactions
increases activity

ISO

Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions
increases activity

ISO

Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

C-C motif chemokine ligand 11

multiple interactions

ISO

zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]

NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,525,862...67,530,575

G

C-C motif chemokine ligand 12

multiple interactions

ISO

zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA]

PMID:12388339 PMID:12794006

NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,567,876...67,569,426

G

C-C motif chemokine ligand 2

multiple interactions

ISO

zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA]

PMID:12388339 PMID:12794006

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

collagen type X alpha 1 chain

increases expression

ISO

zileuton results in increased expression of COL10A1 mRNA

NCBI chr20:39,737,536...39,744,518
Ensembl chr20:39,716,822...39,751,440

G

collagen type II alpha 1 chain

increases expression

ISO

zileuton results in increased expression of COL2A1 mRNA

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

EXP

zileuton results in increased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

zileuton inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
zileuton results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

EXP

zileuton results in increased expression of CYP2B2 mRNA

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

zileuton results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

decreases expression

EXP

zileuton results in decreased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

eosinophil peroxidase

multiple interactions

ISO

zileuton inhibits the reaction [Ovalbumin results in increased expression of EPX protein]

NCBI chr10:73,164,096...73,175,180
Ensembl chr10:73,164,096...73,175,180

G

ferritin heavy chain 1

decreases expression

EXP

zileuton results in decreased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214

G

histone deacetylase 1

decreases expression

EXP

zileuton results in decreased expression of HDAC1 mRNA

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

EXP

zileuton results in decreased expression of HMGCS1 mRNA

NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802

G

hydroxysteroid 11-beta dehydrogenase 2

increases activity

ISO

zileuton results in increased activity of HSD11B2 protein

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812

G

intercellular adhesion molecule 1

affects expression
multiple interactions

ISO

zileuton affects the expression of ICAM1 protein
zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of ICAM1 protein]

PMID:15266012 PMID:15821759

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 12A

multiple interactions

ISO

zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

ISO

zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 13

affects expression
multiple interactions

ISO
EXP

zileuton affects the expression of IL13 protein
zileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]

PMID:12654629 PMID:12794006 PMID:15927844

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483

G

interleukin 1 beta

multiple interactions

ISO

zileuton inhibits the reaction [Bleomycin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

multiple interactions

ISO

zileuton inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
decreases secretion

ISO

zileuton inhibits the reaction [Endotoxins results in increased expression of IL6 protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]
zileuton results in decreased secretion of IL6 protein

PMID:7496871 PMID:19118273 PMID:20436887

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha M

multiple interactions

ISO

zileuton inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

mitogen activated protein kinase 1

affects expression

ISO

zileuton affects the expression of MAPK1 protein modified form

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

affects expression
decreases expression

ISO
EXP

zileuton affects the expression of MAPK3 protein modified form
zileuton results in decreased expression of MAPK3 mRNA

PMID:12883083 PMID:18059327

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

microsomal glutathione S-transferase 1

decreases activity

EXP

zileuton results in decreased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

matrix metallopeptidase 9

decreases activity
decreases expression

EXP

zileuton results in decreased activity of MMP9 protein
zileuton results in decreased expression of MMP9 mRNA

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions
decreases activity

ISO
EXP

zileuton inhibits the reaction [Bleomycin results in increased activity of MPO protein]; zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased activity of MPO protein]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MPO protein]; zileuton inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
zileuton results in decreased activity of MPO protein
zileuton inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; zileuton inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:7812673 PMID:11698051 PMID:12794006 PMID:15339030 PMID:15821759 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO
EXP

zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]

PMID:12654629 PMID:12794006

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

nitric oxide synthase 1

multiple interactions

ISO

[zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1

NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837

G

occludin

multiple interactions

ISO

zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

platelet-activating factor receptor

multiple interactions

ISO

zileuton binds to and results in decreased activity of PTAFR protein; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]

NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:150,049,460...150,079,408

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

ISO

zileuton affects the expression of PTGS2 protein
zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

PMID:18059327 PMID:28487374

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

ribosomal protein lateral stalk subunit P0

decreases expression

EXP

zileuton results in decreased expression of RPLP0 mRNA

NCBI chr12:46,715,121...46,718,390
Ensembl chr12:46,715,124...46,718,422

G

selectin E

multiple interactions

ISO

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

selectin P

multiple interactions

ISO

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]
zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]

PMID:11116075 PMID:15821759

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987

G

SRY-box transcription factor 9

increases expression

ISO

zileuton results in increased expression of SOX9 mRNA

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

tight junction protein 1

multiple interactions

ISO

zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

tumor necrosis factor

affects expression
multiple interactions

ISO

zileuton affects the expression of TNF protein
zileuton inhibits the reaction [Bleomycin results in increased expression of TNF protein]
zileuton inhibits the reaction [Endotoxins results in increased expression of TNF protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]

PMID:7496871 PMID:17118201 PMID:18059327 PMID:19118273

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

vascular cell adhesion molecule 1

multiple interactions

ISO

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
role	20844
biological role	20831
biochemical role	19888
enzyme inhibitor	18710
EC 1.* (oxidoreductase) inhibitor	17657
EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor	2019
EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor	2019
lipoxygenase inhibitor	1601
(+)-lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside	0
(10E,12Z,15Z)-9-hydroxy-10,12,15-octadecatrienoic acid methyl ester	0
(6Z,9Z,12Z,15Z)-henicosa-1,6,9,12,15-pentaene	0
1-[(3-methylbutanoyl)phloroglucinyl]-beta-D-glucopyranoside	0
1-[(pentanoyl)-phloroglucinyl]-beta-D-glucopyranoside	0
4-nitrocatechol	2
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor +	145
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor +	829
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor +	286
ampelopsin B	0
asperenone	0
bacteriohopane-32,33,34,35-tetrol	0
ballodiolic acid	0
ballotenic acid	0
clonixin	0
clonixin lysine salt	0
curcumin	987
masoprocol	72
negundin B	0
nigerloxin	0
onosmin A	0
onosmin B	0
patuletin	0
procyanidin C1	0
proglumetacin +	0
proglumetacin dimaleate	0
silychristin	9
tepoxalin	5

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