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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxarsone
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Accession:CHEBI:35817 term browser browse the term
Definition:An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.
Synonyms:exact_synonym: (4-hydroxy-3-nitrophenyl)arsonic acid
 related_synonym: 2-nitro-1-hydroxybenzene-4-arsonic acid;   3-Nitro;   3-nitro-4-hydroxybenzenearsonic acid;   3-nitro-4-hydroxyphenylarsonic acid;   4-hydroxy-3-nitrobenzenearsonic acid;   4-hydroxy-3-nitrophenylarsonic acid;   Formula=C6H6AsNO6;   InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12);   InChIKey=XMVJITFPVVRMHC-UHFFFAOYSA-N;   NSC-2101;   Ren-O-Sal;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[As](O)(O)=O;   roxarson;   roxarsonum
 xref: CAS:121-19-7;   Gmelin:1221211;   LINCS:LSM-5383
 xref_mesh: MESH:D012406
 xref: PMID:12724787;   PMID:12731831;   PMID:12731832;   PMID:18414637;   PMID:21388897;   Patent:DE224953;   Patent:GB226255;   Reaxys:1976533;   VSDB:3003;   Wikipedia:Roxarsone


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roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 decreases expression ISO Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Cnmd chondromodulin decreases expression ISO Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr15:61,450,617...61,475,382
Ensembl chr15:61,450,450...61,475,350 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion ISO Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Fhdc1 FH2 domain containing 1 decreases expression ISO Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 2:172,088,987...172,127,838
Ensembl chr 2:172,089,010...172,125,956 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Lep leptin decreases expression ISO Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
multiple interactions 		EXP Roxarsone results in increased expression of MTOR mRNA
Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein] 		CTD PMID:35985552 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression
multiple interactions 		ISO Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein] 		CTD PMID:30028964 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839 		JBrowse link
G Plg plasminogen decreases expression ISO Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases expression 		EXP Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]
Roxarsone results in increased expression of RPS6KB1 mRNA 		CTD PMID:35985552 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        agrochemical 17121
          roxarsone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      chalcogen 20492
                        oxygen atom 20458
                          oxygen molecular entity 20446
                            hydroxides 20231
                              oxoacid 19291
                                pnictogen oxoacid 15115
                                  arsenic oxoacid 4268
                                    arsonic acids 661
                                      arsonic acid 661
                                        organoarsonic acid 663
                                          phenylarsonic acid 16
                                            roxarsone 14
paths to the root