gadolinium molecular entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gadolinium molecular entity	go back to main search page
Accession:	CHEBI:35729	browse the term
Synonyms:	related_synonym:	gadolinium compounds; gadolinium molecular entities

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Rat (243) Mouse (242) Human (253) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (243)

gadobutrol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadobutrol results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

fatty acid binding protein 4

decreases expression

gadobutrol results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadobutrol results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

gadodiamide hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadodiamide results in decreased expression of ADIPOQ mRNA; gadodiamide results in decreased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

increases expression

gadodiamide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

ankyrin repeat domain 22

increases expression

gadodiamide results in increased expression of ANKRD22 mRNA

NCBI chr 1:231,639,035...231,670,537
Ensembl chr 1:231,639,314...231,670,381

G

ATM serine/threonine kinase

increases expression

gadodiamide results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase phospholipid transporting 8B1

increases expression

gadodiamide results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

C-C motif chemokine ligand 2

increases expression
increases secretion

gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein
gadodiamide results in increased secretion of CCL2 protein

PMID:20938346 PMID:20959327

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

increases expression

gadodiamide results in increased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

gadodiamide results in increased expression of CCL7 protein

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

centrosomal protein 15

increases expression

gadodiamide results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

C-X-C motif chemokine ligand 10

increases expression
increases secretion

gadodiamide results in increased expression of CXCL10 mRNA
gadodiamide results in increased expression of CXCL10 protein
gadodiamide results in increased secretion of CXCL10 protein

PMID:20938346 PMID:20959327

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

increases secretion
increases expression

gadodiamide results in increased secretion of CXCL11 protein
gadodiamide results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 12

increases expression

gadodiamide results in increased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

increases expression

gadodiamide results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

fatty acid binding protein 4

decreases expression

gadodiamide results in decreased expression of FABP4 mRNA; gadodiamide results in decreased expression of FABP4 protein

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

indoleamine 2,3-dioxygenase 1

increases expression

gadodiamide results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon-induced protein 44-like

increases expression

gadodiamide results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

gadodiamide results in increased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

increases expression

gadodiamide results in increased expression of IFNG mRNA; gadodiamide results in increased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 13

increases expression

gadodiamide results in increased expression of IL13 mRNA; gadodiamide results in increased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

increases expression

gadodiamide results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 4

increases expression
affects expression

gadodiamide results in increased expression of IL4 protein
gadodiamide affects the expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 induced 1

increases expression

gadodiamide results in increased expression of IL4I1 mRNA

NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562

G

interleukin 6

affects expression
increases expression

gadodiamide affects the expression of IL6 protein
gadodiamide results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

KIT ligand

increases expression

gadodiamide results in increased expression of KITLG protein

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
gadodiamide results in increased expression of MMP1 mRNA; gadodiamide results in increased expression of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

nitric oxide synthase 2

increases expression

gadodiamide results in increased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neurexophilin and PC-esterase domain family, member 3

increases expression

gadodiamide results in increased expression of NXPE3 mRNA

NCBI chr11:44,726,905...44,777,694
Ensembl chr11:44,727,069...44,777,694

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadodiamide results in decreased expression of PPARG mRNA; gadodiamide results in decreased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

RELA proto-oncogene, NF-kB subunit

increases localization

gadodiamide results in increased localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member Q

increases expression

gadodiamide results in increased expression of RHOQ mRNA

NCBI chr 6:7,613,632...7,652,047
Ensembl chr 1:106,622,141...106,623,699

G

Ras-like without CAAX 1

increases expression

gadodiamide results in increased expression of RIT1 mRNA

NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455

G

ring finger protein 125

increases expression

gadodiamide results in increased expression of RNF125 mRNA

NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983

G

radical S-adenosyl methionine domain containing 2

increases expression

gadodiamide results in increased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

solute carrier family 39 member 10

increases expression

gadodiamide results in increased expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325

G

sialophorin

increases expression

gadodiamide results in increased expression of SPN mRNA

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

secreted phosphoprotein 1

increases expression

gadodiamide results in increased expression of SPP1 protein

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transforming growth factor, beta 1

increases expression

gadodiamide results in increased expression of TGFB1 mRNA; gadodiamide results in increased expression of TGFB1 protein

PMID:19404939 PMID:20938346

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

gadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]

PMID:19561517 PMID:20938346

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

ubiquitin D

increases expression

gadodiamide results in increased expression of UBD mRNA

NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

vascular endothelial growth factor A

increases expression

gadodiamide results in increased expression of VEGFA mRNA; gadodiamide results in increased expression of VEGFA protein

PMID:19404939 PMID:20938346

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

WD repeat domain 5

increases expression

gadodiamide results in increased expression of WDR5 mRNA

NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671

G

X-linked inhibitor of apoptosis

increases expression

gadodiamide results in increased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

zinc finger protein 652

increases expression

gadodiamide results in increased expression of ZNF652 mRNA

NCBI chr10:80,626,555...80,706,397
Ensembl chr10:80,649,400...80,698,674

gadolinium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

acetyl-CoA carboxylase alpha

multiple interactions

gadolinium chloride promotes the reaction [Ethanol results in decreased expression of ACACA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of ACACA mRNA

PMID:28882574 PMID:34878122

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA thioesterase 1

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of ACOT1 mRNA]

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

actin alpha 2, smooth muscle

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
gadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]

PMID:25813056 PMID:28882574

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadolinium chloride results in decreased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

apolipoprotein B

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

activating transcription factor 4

affects expression

gadolinium chloride affects the expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
gadolinium chloride affects the expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2, apoptosis regulator

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basic helix-loop-helix ARNT like 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of BMAL1 protein

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 2

multiple interactions

gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

caspase 3

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]

PMID:25813056 PMID:26177832

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin E1

increases expression

gadolinium chloride results in increased expression of CCNE1

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

CD163 molecule

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]

PMID:25813056 PMID:26177832

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

Cd68 molecule

multiple interactions

gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]

PMID:23438451 PMID:25813056 PMID:26177832

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

carnitine palmitoyltransferase 1A

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of CPT1A mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CPT1A mRNA

PMID:22648072 PMID:34878122

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

C-X-C motif chemokine ligand 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]

PMID:22157104 PMID:26177832

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone results in increased expression of CXCL1 mRNA]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]

PMID:10918498 PMID:18202523

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein]; gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]

PMID:18079364 PMID:18202523

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA]

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

DNA-damage inducible transcript 3

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]
gadolinium chloride affects the expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

gadolinium chloride results in increased expression of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 4

decreases expression

gadolinium chloride results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid synthase

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of FASN protein]

PMID:25813056 PMID:28882574

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glutamic--pyruvic transaminase

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; gadolinium chloride inhibits the reaction [Vitamin A results in increased activity of GPT protein]
gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]

PMID:8627517 PMID:25900201 PMID:26177832

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hepcidin antimicrobial peptide

increases expression

gadolinium chloride results in increased expression of HAMP

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hemojuvelin BMP co-receptor

decreases expression

gadolinium chloride results in decreased expression of HJV

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

high mobility group box 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
affects expression

gadolinium chloride results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]
gadolinium chloride affects the expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

affects expression
increases expression

gadolinium chloride affects the expression of IFNG protein
gadolinium chloride results in increased expression of IFNG mRNA

PMID:15590129 PMID:19404939

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in decreased expression of IL10 protein]

PMID:22648072 PMID:26177832

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

increases expression

gadolinium chloride results in increased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

gadolinium chloride results in increased expression of IL1B
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of IL1B protein]

PMID:19721414 PMID:22648072 PMID:25813056 PMID:34878122

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

affects expression

gadolinium chloride affects the expression of IL4 mRNA; gadolinium chloride affects the expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL6 mRNA
gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
gadolinium chloride results in increased expression of IL6
gadolinium chloride results in increased expression of IL6 mRNA

PMID:12127824 PMID:12963478 PMID:19404939 PMID:19721414 PMID:24849676 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lipase E, hormone sensitive type

multiple interactions

gadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

lymphotoxin beta

increases expression

gadolinium chloride results in increased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK1 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
gadolinium chloride results in increased activity of MAPK1 protein
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK1 protein]

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK3 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK3 protein]
gadolinium chloride results in increased activity of MAPK3 protein

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 13

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA; SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA
gadolinium chloride results in increased expression of MMP14 mRNA; gadolinium chloride results in increased expression of MMP14 protein

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 9

increases expression
multiple interactions

gadolinium chloride results in increased expression of MMP9 mRNA
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFKB1 mRNA

PMID:15025948 PMID:34878122

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

increases expression

gadolinium chloride results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

platelet derived growth factor subunit A

decreases expression

gadolinium chloride results in decreased expression of PDGFA mRNA

NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

decreases expression

gadolinium chloride results in decreased expression of PDGFB mRNA

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

peroxisome proliferator activated receptor alpha

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadolinium chloride results in decreased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein tyrosine kinase 2

increases activity

gadolinium chloride results in increased activity of PTK2

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RB transcriptional corepressor 1

increases phosphorylation

gadolinium chloride results in increased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of RELA protein

PMID:15025948 PMID:34878122

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A8

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

stearoyl-CoA desaturase

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of SCD1 protein]

PMID:25813056 PMID:28882574

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 40 member 1

decreases expression

gadolinium chloride results in decreased expression of SLC40A1

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

secreted phosphoprotein 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SQSTM1 mRNA

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of TGFB1 mRNA
gadolinium chloride results in increased expression of TGFB1 protein
gadolinium chloride results in increased expression of TGFB1 mRNA
gadolinium chloride affects the expression of TGFB1 mRNA

PMID:11408273 PMID:15590129 PMID:15964588 PMID:19404939 PMID:34878122

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]

PMID:25813056 PMID:26177832

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
gadolinium trichloride inhibits the reaction [estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver]]
gadolinium chloride inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
gadolinium chloride results in increased expression of TNF
gadolinium chloride results in increased expression of TNF mRNA

CTD
RGD

PMID:12127824 PMID:12963478 PMID:14687926 PMID:15025948 PMID:15590129 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases expression

gadolinium chloride results in increased expression of TNFRSF11B mRNA

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

increases expression

gadolinium chloride results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

increases expression

gadolinium chloride results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

decreases expression

gadolinium chloride results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

uncoupling protein 2

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vascular endothelial growth factor A

increases expression

gadolinium chloride results in increased expression of VEGFA mRNA; gadolinium chloride results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

increases splicing

gadolinium chloride results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

motexafin gadolinium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
motexafin gadolinium results in decreased expression of AGL mRNA

NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]
motexafin gadolinium results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ALDH6A1 mRNA
Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

Rho GTPase activating protein 17

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ARHGAP17 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

activating transcription factor 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]
motexafin gadolinium results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATM serine/threonine kinase

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]
motexafin gadolinium results in increased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ATR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

BTB domain and CNC homolog 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BACH1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BAG cochaperone 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]
motexafin gadolinium results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

Bcl-2 binding component 3

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]
motexafin gadolinium results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BNIP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BNIP3L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

calnexin

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

core-binding factor subunit beta

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751

G

cyclin J

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
motexafin gadolinium results in decreased expression of CCNJ mRNA

NCBI chr 1:239,659,588...239,677,367

G

cell division cycle 16

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDC16 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA

NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 25C

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDC25C mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 27

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 5-like

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cell division cycle associated 2

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDCA2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cyclin-dependent kinase 19

increases expression

motexafin gadolinium results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]
motexafin gadolinium results in increased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDKN1B mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cystathionine gamma-lyase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cullin 3

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CUL3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA

NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462

G

cytochrome b5 reductase 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA
motexafin gadolinium results in increased expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

death-associated protein kinase 3

multiple interactions
decreases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]
motexafin gadolinium results in decreased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]
motexafin gadolinium results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DDIT4 mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

death effector domain containing 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]
motexafin gadolinium results in increased expression of DEDD2 mRNA

NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714

G

DNA fragmentation factor subunit beta

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of DFFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

7-dehydrocholesterol reductase

decreases expression

motexafin gadolinium results in decreased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]
motexafin gadolinium results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DNAJB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DNAJB6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]
motexafin gadolinium results in increased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

E2F transcription factor 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA
motexafin gadolinium results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of E2F3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

elongator acetyltransferase complex subunit 1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ELP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

enolase 1

increases expression

motexafin gadolinium results in increased expression of ENO1 mRNA

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

Fas associated via death domain

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of FADD mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas apoptotic inhibitory molecule

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of FAIM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 162, member A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of FAM162A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

G

fatty acid synthase

decreases expression

motexafin gadolinium results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

forkhead box O3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of FOXO3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA
motexafin gadolinium results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutaminase

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of GLS mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

G protein-coupled receptor 146

increases expression

motexafin gadolinium results in increased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

glutamic--pyruvic transaminase 2

increases expression

motexafin gadolinium results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 1

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of GSR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIIC subunit 2

increases expression

motexafin gadolinium results in increased expression of GTF3C2 mRNA

NCBI chr 6:25,196,439...25,221,338
Ensembl chr 6:25,197,268...25,220,490

G

HMG-box transcription factor 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA
motexafin gadolinium results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
motexafin gadolinium results in increased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible lipid droplet-associated

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HILPDA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]
motexafin gadolinium results in increased expression of HIPK1 mRNA

NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902

G

helicase-like transcription factor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
motexafin gadolinium results in decreased expression of HLTF mRNA

NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327

G

heme oxygenase 1

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
motexafin gadolinium results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

harakiri, BCL2 interacting protein

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA
motexafin gadolinium results in increased expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
motexafin gadolinium results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 4 like

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPA4L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]
motexafin gadolinium results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]
motexafin gadolinium results in increased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family H (Hsp110) member 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPH1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

inhibitor of DNA binding 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of ID2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression
multiple interactions

motexafin gadolinium results in increased expression of IKBKE mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

interferon regulatory factor 2 binding protein 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of IRF2BP2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

motexafin gadolinium results in increased expression of JUND mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

lysine demethylase 3A

increases expression

motexafin gadolinium results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

MDM2 proto-oncogene

increases expression
multiple interactions

motexafin gadolinium results in increased expression of MDM2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MOB kinase activator 1A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:115,831,581...115,848,561
Ensembl chr 4:115,831,551...115,848,561
Ensembl chr 1:115,831,551...115,848,561

G

metallothionein 1

multiple interactions

[Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
motexafin gadolinium results in increased expression of MT1E mRNA

PMID:15867382 PMID:16357179

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]
motexafin gadolinium results in increased expression of MT1HL1 mRNA

PMID:15867382 PMID:16357179

NCBI chr20:3,159,037...3,159,409
Ensembl chr 5:119,728,811...119,730,073

G

metallothionein 2A

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]
motexafin gadolinium results in increased expression of MT2A mRNA

PMID:15867382 PMID:16357179

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA
motexafin gadolinium results in decreased expression of MYD88 mRNA

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NAD kinase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of NADK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA

NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322

G

neurofibromin 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA
motexafin gadolinium results in increased expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

nischarin

decreases expression

motexafin gadolinium results in decreased expression of NISCH mRNA

NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668

G

nuclear receptor subfamily 1, group D, member 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of NR1D2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]
motexafin gadolinium results in increased expression of P4HB mRNA

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

programmed cell death 11

decreases expression

motexafin gadolinium results in decreased expression of PDCD11 mRNA

NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999

G

programmed cell death 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PDCD4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

programmed cell death 5

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of PDCD5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PFKFB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PFKFB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phosphoglycerate kinase 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]
motexafin gadolinium results in increased expression of PHTF2 mRNA

NCBI chr 4:14,215,190...14,330,549
Ensembl chr 4:14,215,263...14,330,513

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]
motexafin gadolinium results in increased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905

G

phosphoinositide-3-kinase interacting protein 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PIK3IP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA

NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA
motexafin gadolinium results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
motexafin gadolinium results in increased expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase C, delta

decreases expression

motexafin gadolinium results in decreased expression of PRKCD mRNA

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase D2

decreases expression

motexafin gadolinium results in decreased expression of PRKD2 mRNA

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

protein kinase, DNA-activated, catalytic subunit

increases expression

motexafin gadolinium results in increased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

peptidyl-tRNA hydrolase 2

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of PTRH2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA

NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398

G

RB transcriptional corepressor 1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of RB1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
motexafin gadolinium results in decreased expression of RCBTB2 mRNA

NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750

G

RELB proto-oncogene, NF-kB subunit

increases expression
multiple interactions

motexafin gadolinium results in increased expression of RELB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

ring finger protein 19B

increases expression

motexafin gadolinium results in increased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
motexafin gadolinium results in increased expression of SAMTOR mRNA

NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539

G

selenoprotein W

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
motexafin gadolinium results in increased expression of SELENOW mRNA

NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724
Ensembl chr 1:76,598,779...76,604,724

G

sestrin 2

multiple interactions
increases expression

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
motexafin gadolinium results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 16 member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]
motexafin gadolinium results in increased expression of SLC16A1 mRNA

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16, member 6

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA
motexafin gadolinium results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]
motexafin gadolinium results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 30 member 1

multiple interactions
increases expression

[Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

PMID:15867382 PMID:16357179

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 38, member 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 39 member 10

multiple interactions
affects expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA
motexafin gadolinium affects the expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325

G

solute carrier family 39 member 14

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC39A14 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39, member 9

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC39A9 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA

NCBI chr 6:100,291,537...100,330,419
Ensembl chr 6:100,291,573...100,330,408

G

solute carrier family 3 member 2

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
motexafin gadolinium results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 43 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
motexafin gadolinium results in increased expression of SLC43A1 mRNA

NCBI chr 3:69,920,586...69,946,768
Ensembl chr 3:69,920,649...69,946,768

G

solute carrier family 7 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
motexafin gadolinium results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7 member 11

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC7A11 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of SMARCA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

SNF2 related chromatin remodeling ATPase 5

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of SMARCA5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594

G

T-cell activation RhoGTPase activating protein

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TAGAP mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA

NCBI chr 1:47,170,725...47,179,705
Ensembl chr 1:47,170,725...47,179,792

G

transferrin receptor

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]
motexafin gadolinium results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TNF alpha induced protein 8

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
motexafin gadolinium results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 8

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]
motexafin gadolinium results in increased expression of TNFSF8 mRNA

NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421

G

TNFAIP3 interacting protein 2

decreases expression

motexafin gadolinium results in decreased expression of TNIP2 mRNA

NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265

G

tumor protein p53

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tribbles pseudokinase 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TRIB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

thioredoxin reductase 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TXNRD1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

vascular endothelial growth factor A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of VEGFA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Hippel-Lindau tumor suppressor

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]
motexafin gadolinium results in increased expression of VHL mRNA

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
chemical entity	19865
molecular entity	19865
transition element molecular entity	17437
f-block molecular entity	409
lanthanoid molecular entity	409
gadolinium molecular entity	243
elemental gadolinium +	0
gadolinium coordination entity +	243
Path 2
Term	Annotations
CHEBI ontology	19867
subatomic particle	19865
composite particle	19865
hadron	19865
baryon	19865
nucleon	19865
atomic nucleus	19865
atom	19865
metal atom	18030
transition element atom	17574
rare earth metal atom	439
lanthanoid atom	437
gadolinium atom	258
gadolinium molecular entity	243
elemental gadolinium +	0
gadolinium coordination entity +	243

paths to the root