lanthanoid coordination entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lanthanoid coordination entity	go back to main search page
Accession:	CHEBI:35728	browse the term
Synonyms:	related_synonym:	lanthanoid coordination compounds; lanthanoid coordination entities

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Rat (320) Mouse (322) Human (331) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (320)

cerium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects expression

cerous chloride affects the expression of ALB mRNA

NCBI chr14:17,891,564...17,907,043

G

arachidonate 12-lipoxygenase, 12S type

decreases expression
multiple interactions

cerous chloride results in decreased expression of ALOX12 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of ALOX12 mRNA

NCBI chr10:55,456,923...55,469,239

G

aldehyde oxidase 1

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980

G

apolipoprotein A4

affects expression

cerous chloride affects the expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160

G

apolipoprotein E

affects expression
multiple interactions

cerous chloride affects the expression of APOE mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816

G

beta-2 microglobulin

increases expression

cerous chloride results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354

G

catalase

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of CAT mRNA
cerous chloride results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

cerous chloride results in increased expression of CCL5 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906

G

copper chaperone for superoxide dismutase

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] affects the expression of CCS mRNA
cerous chloride results in decreased expression of CCS mRNA

NCBI chr 1:202,113,792...202,134,931

G

cyclin-dependent kinase inhibitor 1A

decreases expression

cerous chloride results in decreased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373

G

carboxyl ester lipase

increases expression

cerous chloride results in increased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035

G

complement factor D

affects expression

cerous chloride affects the expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

cerous chloride results in increased expression of CHUK mRNA; cerous chloride results in increased expression of CHUK protein

NCBI chr 1:252,908,748...252,944,273

G

cytoglobin

affects expression
multiple interactions

cerous chloride affects the expression of CYGB mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

cerous chloride results in increased expression of CYP1A1

NCBI chr 8:66,991,940...66,998,014

G

cytochrome P450, family 51

affects expression

cerous chloride affects the expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410

G

cytochrome P450 family 7 subfamily B member 1

increases expression

cerous chloride results in increased expression of CYP7B1 mRNA

NCBI chr 2:102,419,011...102,586,047

G

cytochrome P450 family 8 subfamily B member 1

affects expression

cerous chloride affects the expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592

G

24-dehydrocholesterol reductase

decreases expression

cerous chloride results in decreased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940

G

7-dehydrocholesterol reductase

affects expression

cerous chloride affects the expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408

G

dual oxidase 1

decreases expression
multiple interactions

cerous chloride results in decreased expression of DUOX1 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX1 mRNA

NCBI chr 3:109,260,526...109,295,588

G

dual oxidase 2

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX2 mRNA

NCBI chr 3:109,223,809...109,247,023

G

dual specificity phosphatase 1

multiple interactions
affects expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUSP1 mRNA
cerous chloride affects the expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

EBP, cholestenol delta-isomerase

affects expression

cerous chloride affects the expression of EBP mRNA

NCBI chr X:14,299,427...14,305,826

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

cerous chloride affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647

G

epoxide hydrolase 2

affects expression
multiple interactions

cerous chloride affects the expression of EPHX2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157

G

eosinophil peroxidase

decreases expression

cerous chloride results in decreased expression of EPX mRNA

NCBI chr10:73,164,096...73,175,180

G

forkhead box M1

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of FOXM1 mRNA
cerous chloride results in decreased expression of FOXM1 mRNA

NCBI chr 4:163,325,628...163,338,100

G

ferritin heavy chain 1

increases expression

cerous chloride results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

cerous chloride results in decreased expression of GAPDH mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

cerous chloride results in increased expression of GCLC mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896

G

glutamate cysteine ligase, modifier subunit

decreases expression

cerous chloride results in decreased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192

G

glycerol-3-phosphate dehydrogenase 2

affects expression

cerous chloride affects the expression of GPD2 mRNA

NCBI chr 3:41,800,552...41,937,729

G

glutathione peroxidase 2

decreases expression

cerous chloride results in decreased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033

G

glutathione peroxidase 3

multiple interactions
affects expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of GPX3 mRNA
cerous chloride affects the expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406

G

glutathione peroxidase 4

affects expression

cerous chloride affects the expression of GPX4 mRNA

NCBI chr 7:10,300,833...10,303,629

G

glutathione peroxidase 7

decreases expression
multiple interactions

cerous chloride results in decreased expression of GPX7 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GPX7 mRNA

NCBI chr 5:123,145,151...123,153,141

G

growth factor receptor bound protein 2

affects expression

cerous chloride affects the expression of GRB2 mRNA

NCBI chr10:101,380,354...101,448,138

G

glutathione S-transferase pi 1

decreases expression

cerous chloride results in decreased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242

G

glutathione S-transferase zeta 1

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of GSTZ1 mRNA

NCBI chr 6:106,794,594...106,805,284

G

general transcription factor II I

decreases expression

cerous chloride results in decreased expression of GTF2I mRNA

NCBI chr12:22,400,933...22,476,243

G

heme oxygenase 1

multiple interactions
affects expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of HMOX1 mRNA
cerous chloride affects the expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823

G

heat shock protein family A (Hsp70) member 1A

decreases expression

cerous chloride results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866

G

interferon gamma

increases expression

cerous chloride results in increased expression of IFNG

NCBI chr 7:55,789,180...55,793,216

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases expression

cerous chloride results in increased expression of IKBKB mRNA; cerous chloride results in increased expression of IKBKB protein

NCBI chr16:76,021,968...76,075,717

G

interleukin 10

increases expression

cerous chloride results in increased expression of IL10

NCBI chr13:45,024,921...45,029,586

G

interleukin 18

increases expression

cerous chloride results in increased expression of IL18

NCBI chr 8:59,802,072...59,829,275

G

interleukin 1 beta

increases expression

cerous chloride results in increased expression of IL1B

NCBI chr 3:137,030,200...137,036,581

G

interleukin 2

decreases expression
increases expression

cerous chloride results in decreased expression of IL2 mRNA; cerous chloride results in decreased expression of IL2 protein
cerous chloride results in increased expression of IL2

PMID:21656643 PMID:23712967

NCBI chr 2:121,932,968...121,937,672

G

interleukin 4

increases expression

cerous chloride results in increased expression of IL4

NCBI chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
increases expression

IL6 mutant form inhibits the reaction [cerous chloride results in increased expression of SAA protein]
cerous chloride results in increased expression of IL6; cerous chloride results in increased expression of IL6 protein

PMID:16204935 PMID:23712967

NCBI chr 4:5,889,999...5,894,575

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

cerous chloride affects the expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993

G

lactoperoxidase

multiple interactions
increases expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of LPO mRNA
cerous chloride results in increased expression of LPO mRNA

NCBI chr10:72,606,950...72,626,220

G

microtubule-associated protein 1 light chain 3 beta

increases expression

cerous chloride results in increased expression of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270

G

mitogen-activated protein kinase kinase kinase kinase 4

increases expression

cerous chloride results in increased expression of MAP4K4 mRNA; cerous chloride results in increased expression of MAP4K4 protein

NCBI chr 9:42,200,708...42,326,708

G

myoglobin

increases expression
multiple interactions

cerous chloride results in increased expression of MB mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of MB mRNA

NCBI chr 7:110,640,511...110,647,742

G

mannose binding lectin 2

decreases expression
multiple interactions

cerous chloride results in decreased expression of MBL2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567

G

macrophage migration inhibitory factor

increases expression

cerous chloride results in increased expression of MIF

NCBI chr20:12,767,138...12,791,222

G

myeloperoxidase

affects expression

cerous chloride affects the expression of MPO mRNA

NCBI chr10:73,092,124...73,102,057

G

mitochondrial inner membrane protein MPV17

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of MPV17 mRNA
cerous chloride results in decreased expression of MPV17 mRNA

NCBI chr 6:25,221,668...25,236,241

G

methionine sulfoxide reductase A

decreases expression

cerous chloride results in decreased expression of MSRA mRNA

NCBI chr15:42,514,818...42,853,278

G

metallothionein 1

increases expression
multiple interactions

cerous chloride results in increased expression of MT1 protein
cerous chloride promotes the reaction [Zinc binds to MT1 protein]

PMID:15964310 PMID:16204935

NCBI chr19:10,831,959...10,832,975

G

metallothionein 2A

multiple interactions
increases expression

cerous chloride promotes the reaction [Zinc binds to MT2 protein]
cerous chloride results in increased expression of MT2 protein

PMID:15964310 PMID:16204935

NCBI chr19:10,837,934...10,838,708

G

neutrophil cytosolic factor 1

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF1 mRNA

NCBI chr12:28,121,816...28,131,080

G

neutrophil cytosolic factor 2

affects expression
multiple interactions

cerous chloride affects the expression of NCF2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015

G

nuclear factor kappa B subunit 1

increases expression

cerous chloride results in increased expression of NFKB1 mRNA; cerous chloride results in increased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897

G

nuclear factor kappa B subunit 2

increases expression

cerous chloride results in increased expression of NFKB2 mRNA; cerous chloride results in increased expression of NFKB2 protein

NCBI chr 1:255,106,010...255,114,649

G

NFKB inhibitor beta

decreases expression

cerous chloride results in decreased expression of NFKBIB mRNA; cerous chloride results in decreased expression of NFKBIB protein

NCBI chr 1:93,173,817...93,181,387

G

nicotinamide N-methyltransferase

affects expression

cerous chloride affects the expression of NNMT mRNA

NCBI chr 8:57,820,156...57,851,301

G

nitric oxide synthase 2

decreases expression
multiple interactions

cerous chloride results in decreased expression of NOS2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221

G

nucleophosmin 1

multiple interactions

cerous chloride results in decreased expression of and affects the localization of NPM1 protein

NCBI chr10:17,741,512...17,751,626

G

5' nucleotidase, ecto

decreases expression

cerous chloride results in decreased expression of NT5E mRNA

NCBI chr 8:98,150,925...98,195,646

G

nudix hydrolase 1

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of NUDT1 mRNA
cerous chloride results in decreased expression of NUDT1 mRNA

NCBI chr12:14,302,514...14,309,559

G

proliferating cell nuclear antigen

affects expression
multiple interactions

cerous chloride affects the expression of PCNA protein
[cerous chloride co-treated with lanthanum chloride] affects the expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820

G

polynucleotide kinase 3'-phosphatase

decreases expression

cerous chloride results in decreased expression of PNKP mRNA

NCBI chr 1:95,341,465...95,346,921

G

peroxiredoxin 1

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PRDX1 mRNA
cerous chloride results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504

G

peroxiredoxin 2

decreases expression

cerous chloride results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083

G

peroxiredoxin 5

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of PRDX5 mRNA

NCBI chr 1:213,529,042...213,532,787

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PREX1 mRNA

NCBI chr 3:175,724,939...175,875,764

G

prostaglandin-endoperoxide synthase 2

decreases expression

cerous chloride results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320

G

peroxidasin

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PXDN mRNA
cerous chloride results in decreased expression of PXDN mRNA

NCBI chr 6:46,580,749...46,658,345

G

RAD51 recombinase

multiple interactions

[cerous chloride co-treated with Cisplatin] results in increased expression of RAD51 protein

NCBI chr 3:126,554,210...126,578,888

G

RELA proto-oncogene, NF-kB subunit

increases expression

cerous chloride results in increased expression of RELA mRNA; cerous chloride results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815

G

scavenger receptor class A, member 3

decreases expression

cerous chloride results in decreased expression of SCARA3 mRNA

NCBI chr15:44,315,422...44,348,416

G

selenoprotein P

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SELENOP mRNA

NCBI chr 2:54,225,736...54,236,022

G

sirtuin 2

multiple interactions
decreases expression
increases expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SIRT2 mRNA
cerous chloride results in decreased expression of SIRT2 mRNA
cerous chloride results in increased expression of SIRT2 mRNA

NCBI chr 1:93,181,472...93,204,499

G

superoxide dismutase 1

decreases activity

cerous chloride results in decreased activity of SOD1 protein

NCBI chr11:42,942,742...42,948,399

G

superoxide dismutase 2

decreases activity
multiple interactions

cerous chloride results in decreased activity of SOD2 protein
[cerous chloride co-treated with lanthanum chloride] results in increased expression of SOD2 mRNA

PMID:15964310 PMID:28954213

NCBI chr 1:50,043,323...50,050,168

G

sequestosome 1

multiple interactions
affects expression

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SQSTM1 mRNA
cerous chloride affects the expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750

G

sulfiredoxin 1

multiple interactions

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372

G

serine/threonine kinase 25

decreases expression
multiple interactions

cerous chloride results in decreased expression of STK25 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of STK25 mRNA

NCBI chr 9:94,161,834...94,174,095

G

transforming growth factor, beta 1

increases expression

cerous chloride results in increased expression of TGFB1

NCBI chr 1:90,324,312...90,340,627

G

toll-like receptor 2

increases expression

cerous chloride results in increased expression of TLR2 mRNA; cerous chloride results in increased expression of TLR2 protein

NCBI chr 2:171,499,189...171,504,831

G

toll-like receptor 4

increases expression

cerous chloride results in increased expression of TLR4 mRNA; cerous chloride results in increased expression of TLR4 protein

NCBI chr 5:85,161,247...85,174,882

G

tumor necrosis factor

increases expression

cerous chloride results in increased expression of TNF; cerous chloride results in increased expression of TNF mRNA; cerous chloride results in increased expression of TNF protein

PMID:21656643 PMID:23712967

NCBI chr20:3,626,685...3,629,303

G

thioredoxin 1

increases expression

cerous chloride results in increased expression of TXN mRNA

NCBI chr 5:77,507,455...77,519,685

G

thioredoxin reductase 1

increases expression

cerous chloride results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553

G

thioredoxin reductase 2

decreases expression

cerous chloride results in decreased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475

G

uncoupling protein 2

multiple interactions
decreases expression

[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA
cerous chloride results in decreased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742

G

zeta chain of T cell receptor associated protein kinase 70

affects expression

cerous chloride affects the expression of ZAP70 mRNA

NCBI chr 9:46,485,605...46,507,552

gadobutrol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadobutrol results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244

G

fatty acid binding protein 4

decreases expression

gadobutrol results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadobutrol results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104

gadodiamide hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadodiamide results in decreased expression of ADIPOQ mRNA; gadodiamide results in decreased expression of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131

G

aldehyde dehydrogenase 1 family, member A1

increases expression

gadodiamide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497

G

ankyrin repeat domain 22

increases expression

gadodiamide results in increased expression of ANKRD22 mRNA

NCBI chr 1:241,052,235...241,083,737

G

ATM serine/threonine kinase

increases expression

gadodiamide results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040

G

ATPase phospholipid transporting 8B1

increases expression

gadodiamide results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213

G

C-C motif chemokine ligand 2

increases expression
increases secretion

gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein
gadodiamide results in increased secretion of CCL2 protein

PMID:20938346 PMID:20959327

NCBI chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 4

increases expression

gadodiamide results in increased expression of CCL4 protein

NCBI chr10:68,963,893...68,965,728

G

C-C motif chemokine ligand 7

increases expression

gadodiamide results in increased expression of CCL7 protein

NCBI chr10:67,514,095...67,515,945

G

centrosomal protein 15

increases expression

gadodiamide results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115

G

C-X-C motif chemokine ligand 10

increases expression
increases secretion

gadodiamide results in increased expression of CXCL10 mRNA
gadodiamide results in increased expression of CXCL10 protein
gadodiamide results in increased secretion of CXCL10 protein

PMID:20938346 PMID:20959327

NCBI chr14:15,989,066...15,991,263

G

C-X-C motif chemokine ligand 11

increases secretion
increases expression

gadodiamide results in increased secretion of CXCL11 protein
gadodiamide results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207

G

C-X-C motif chemokine ligand 12

increases expression

gadodiamide results in increased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628

G

C-X-C motif chemokine ligand 9

increases expression

gadodiamide results in increased expression of CXCL9 mRNA

NCBI chr14:16,007,166...16,012,077

G

fatty acid binding protein 4

decreases expression

gadodiamide results in decreased expression of FABP4 mRNA; gadodiamide results in decreased expression of FABP4 protein

NCBI chr 2:93,488,251...93,492,961

G

indoleamine 2,3-dioxygenase 1

increases expression

gadodiamide results in increased expression of IDO1 mRNA

NCBI chr16:74,133,259...74,145,328

G

interferon-induced protein 44-like

increases expression

gadodiamide results in increased expression of IFI44L mRNA

NCBI chr 2:243,328,629...243,366,404

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

gadodiamide results in increased expression of IFIT3 mRNA

NCBI chr 1:241,527,326...241,532,469

G

interferon gamma

increases expression

gadodiamide results in increased expression of IFNG mRNA; gadodiamide results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216

G

interleukin 13

increases expression

gadodiamide results in increased expression of IL13 mRNA; gadodiamide results in increased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483

G

interleukin 1 alpha

increases expression

gadodiamide results in increased expression of IL1A protein

NCBI chr 3:136,979,804...136,990,236

G

interleukin 4

increases expression
affects expression

gadodiamide results in increased expression of IL4 protein
gadodiamide affects the expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549

G

interleukin 4 induced 1

increases expression

gadodiamide results in increased expression of IL4I1 mRNA

NCBI chr 1:95,299,457...95,324,564

G

interleukin 6

affects expression
increases expression

gadodiamide affects the expression of IL6 protein
gadodiamide results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575

G

KIT ligand

increases expression

gadodiamide results in increased expression of KITLG protein

NCBI chr 7:36,782,621...36,863,796

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411

G

matrix metallopeptidase 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
gadodiamide results in increased expression of MMP1 mRNA; gadodiamide results in increased expression of MMP1 protein

NCBI chr 8:12,943,453...12,963,966

G

nitric oxide synthase 2

increases expression

gadodiamide results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221

G

neurexophilin and PC-esterase domain family, member 3

increases expression

gadodiamide results in increased expression of NXPE3 mRNA

NCBI chr11:44,726,905...44,777,694

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadodiamide results in decreased expression of PPARG mRNA; gadodiamide results in decreased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104

G

RELA proto-oncogene, NF-kB subunit

increases localization

gadodiamide results in increased localization of RELA protein

NCBI chr 1:212,354,336...212,364,815

G

ras homolog family member Q

increases expression

gadodiamide results in increased expression of RHOQ mRNA

NCBI chr 6:7,613,632...7,652,047

G

Ras-like without CAAX 1

increases expression

gadodiamide results in increased expression of RIT1 mRNA

NCBI chr 2:176,478,616...176,493,269

G

ring finger protein 125

increases expression

gadodiamide results in increased expression of RNF125 mRNA

NCBI chr18:12,528,995...12,550,646

G

radical S-adenosyl methionine domain containing 2

increases expression

gadodiamide results in increased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245

G

solute carrier family 39 member 10

increases expression

gadodiamide results in increased expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325

G

sialophorin

increases expression

gadodiamide results in increased expression of SPN mRNA

NCBI chr 1:181,746,937...181,759,564

G

secreted phosphoprotein 1

increases expression

gadodiamide results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695

G

transforming growth factor, beta 1

increases expression

gadodiamide results in increased expression of TGFB1 mRNA; gadodiamide results in increased expression of TGFB1 protein

PMID:19404939 PMID:20938346

NCBI chr 1:90,324,312...90,340,627

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

gadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]

PMID:19561517 PMID:20938346

NCBI chr X:3,766,509...3,772,578

G

ubiquitin D

increases expression

gadodiamide results in increased expression of UBD mRNA

NCBI chr20:1,390,734...1,392,685

G

vascular endothelial growth factor A

increases expression

gadodiamide results in increased expression of VEGFA mRNA; gadodiamide results in increased expression of VEGFA protein

PMID:19404939 PMID:20938346

NCBI chr 9:22,452,854...22,468,194

G

WD repeat domain 5

increases expression

gadodiamide results in increased expression of WDR5 mRNA

NCBI chr 3:10,836,964...10,856,682

G

X-linked inhibitor of apoptosis

increases expression

gadodiamide results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979

G

zinc finger protein 652

increases expression

gadodiamide results in increased expression of ZNF652 mRNA

NCBI chr10:80,626,555...80,706,397

gadolinium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]

NCBI chr15:101,948,387...102,182,912

G

acetyl-CoA carboxylase alpha

multiple interactions

gadolinium chloride promotes the reaction [Ethanol results in decreased expression of ACACA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of ACACA mRNA

PMID:28882574 PMID:34878122

NCBI chr10:69,511,627...69,773,888

G

acyl-CoA thioesterase 1

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of ACOT1 mRNA]

NCBI chr 6:109,367,274...109,375,268

G

actin alpha 2, smooth muscle

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503

G

adhesion G protein-coupled receptor E1

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
gadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]

PMID:25813056 PMID:28882574

NCBI chr 9:2,329,398...2,484,959

G

adiponectin, C1Q and collagen domain containing

decreases expression

gadolinium chloride results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244

G

apolipoprotein B

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]

NCBI chr 6:36,563,704...36,603,300

G

activating transcription factor 4

affects expression

gadolinium chloride affects the expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739

G

activating transcription factor 6

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
gadolinium chloride affects the expression of ATF6 mRNA

NCBI chr13:85,460,312...85,639,959

G

BCL2, apoptosis regulator

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900

G

basic helix-loop-helix ARNT like 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of BMAL1 protein

NCBI chr 1:167,331,756...167,430,235

G

bone morphogenetic protein 2

multiple interactions

gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]

NCBI chr 3:141,264,648...141,275,416

G

caspase 3

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794

G

catalase

multiple interactions

gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]

PMID:25813056 PMID:26177832

NCBI chr10:67,503,077...67,504,875

G

cyclin E1

increases expression

gadolinium chloride results in increased expression of CCNE1

NCBI chr 1:99,918,672...99,927,986

G

CD163 molecule

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]

PMID:25813056 PMID:26177832

NCBI chr 4:158,770,751...158,804,146

G

Cd68 molecule

multiple interactions

gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]

PMID:23438451 PMID:25813056 PMID:26177832

NCBI chr10:54,880,562...54,882,441

G

carnitine palmitoyltransferase 1A

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of CPT1A mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CPT1A mRNA

PMID:22648072 PMID:34878122

NCBI chr 1:209,993,881...210,056,329

G

C-X-C motif chemokine ligand 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA]

NCBI chr14:17,477,542...17,479,321

G

C-X-C motif chemokine ligand 2

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]

PMID:22157104 PMID:26177832

NCBI chr14:17,465,210...17,467,255

G

C-X-C motif chemokine ligand 3

multiple interactions

gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone results in increased expression of CXCL1 mRNA]

NCBI chr14:17,571,900...17,573,624

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]

NCBI chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]

PMID:10918498 PMID:18202523

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein]

NCBI chr 1:246,175,216...246,211,445

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein]; gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]

PMID:18079364 PMID:18202523

NCBI chr12:14,321,771...14,343,886

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA]

NCBI chr 5:134,360,096...134,374,233

G

DNA-damage inducible transcript 3

multiple interactions
increases expression
affects expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]
gadolinium chloride affects the expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

gadolinium chloride results in increased expression of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]

NCBI chr10:91,826,663...91,920,976

G

fatty acid binding protein 4

decreases expression

gadolinium chloride results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961

G

fatty acid synthase

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of FASN protein]

PMID:25813056 PMID:28882574

NCBI chr10:106,570,415...106,588,581

G

glutamic--pyruvic transaminase

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; gadolinium chloride inhibits the reaction [Vitamin A results in increased activity of GPT protein]
gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]

PMID:8627517 PMID:25900201 PMID:26177832

NCBI chr 7:110,295,599...110,300,134

G

hepcidin antimicrobial peptide

increases expression

gadolinium chloride results in increased expression of HAMP

NCBI chr 1:95,298,332...95,300,271

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068

G

hemojuvelin BMP co-receptor

decreases expression

gadolinium chloride results in decreased expression of HJV

NCBI chr 2:186,754,801...186,758,708

G

high mobility group box 1

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]

NCBI chr12:11,009,236...11,015,941

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]

NCBI chr 2:188,564,348...188,590,872

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A protein]

NCBI chr20:3,875,411...3,877,866

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
affects expression

gadolinium chloride results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]
gadolinium chloride affects the expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475

G

intercellular adhesion molecule 1

multiple interactions

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618

G

interferon gamma

affects expression
increases expression

gadolinium chloride affects the expression of IFNG protein
gadolinium chloride results in increased expression of IFNG mRNA

PMID:15590129 PMID:19404939

NCBI chr 7:55,789,180...55,793,216

G

insulin-like growth factor 1

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]

NCBI chr 7:24,169,608...24,249,446

G

insulin-like growth factor binding protein 3

multiple interactions

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]

NCBI chr14:86,270,208...86,277,944

G

interleukin 10

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in decreased expression of IL10 protein]

PMID:22648072 PMID:26177832

NCBI chr13:45,024,921...45,029,586

G

interleukin 13

increases expression

gadolinium chloride results in increased expression of IL13 mRNA

NCBI chr10:38,290,926...38,293,483

G

interleukin 1 alpha

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236

G

interleukin 1 beta

increases expression
multiple interactions

gadolinium chloride results in increased expression of IL1B
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of IL1B protein]

PMID:19721414 PMID:22648072 PMID:25813056 PMID:34878122

NCBI chr 3:137,030,200...137,036,581

G

interleukin 4

affects expression

gadolinium chloride affects the expression of IL4 mRNA; gadolinium chloride affects the expression of IL4 protein

NCBI chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL6 mRNA
gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
gadolinium chloride results in increased expression of IL6
gadolinium chloride results in increased expression of IL6 mRNA

PMID:12127824 PMID:12963478 PMID:19404939 PMID:19721414 PMID:24849676 More...

NCBI chr 4:5,889,999...5,894,575

G

lipase E, hormone sensitive type

multiple interactions

gadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]

NCBI chr 1:80,965,612...80,984,313

G

lymphotoxin beta

increases expression

gadolinium chloride results in increased expression of LTB mRNA

NCBI chr20:3,632,209...3,634,054

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK1 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
gadolinium chloride results in increased activity of MAPK1 protein
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK1 protein]

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr11:97,462,025...97,529,193

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases activity

gadolinium chloride results in decreased phosphorylation of MAPK3 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK3 protein]
gadolinium chloride results in increased activity of MAPK3 protein

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr 1:190,797,189...190,803,411

G

matrix metallopeptidase 13

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA; SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]

NCBI chr 8:12,782,829...12,793,108

G

matrix metallopeptidase 14

multiple interactions
increases expression

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA
gadolinium chloride results in increased expression of MMP14 mRNA; gadolinium chloride results in increased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049

G

matrix metallopeptidase 9

increases expression
multiple interactions

gadolinium chloride results in increased expression of MMP9 mRNA
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP9 mRNA]

NCBI chr 3:174,103,474...174,111,434

G

myeloperoxidase

multiple interactions

gadolinium chloride inhibits the reaction [Thioacetamide results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057

G

NFE2 like bZIP transcription factor 2

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165

G

nuclear factor kappa B subunit 1

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFKB1 mRNA

PMID:15025948 PMID:34878122

NCBI chr 2:226,689,745...226,805,897

G

nitric oxide synthase 2

increases expression

gadolinium chloride results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221

G

platelet derived growth factor subunit A

decreases expression

gadolinium chloride results in decreased expression of PDGFA mRNA

NCBI chr12:20,759,366...20,780,337

G

platelet derived growth factor subunit B

decreases expression

gadolinium chloride results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343

G

peroxisome proliferator activated receptor alpha

multiple interactions

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723

G

peroxisome proliferator-activated receptor gamma

decreases expression

gadolinium chloride results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104

G

protein tyrosine kinase 2

increases activity

gadolinium chloride results in increased activity of PTK2

NCBI chr 7:107,015,730...107,220,865

G

RB transcriptional corepressor 1

increases phosphorylation

gadolinium chloride results in increased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of RELA protein

PMID:15025948 PMID:34878122

NCBI chr 1:212,354,336...212,364,815

G

S100 calcium binding protein A8

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]

NCBI chr 2:178,464,095...178,465,223

G

S100 calcium binding protein A9

multiple interactions

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]

NCBI chr 2:178,487,941...178,490,622

G

stearoyl-CoA desaturase

multiple interactions

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of SCD1 protein]

PMID:25813056 PMID:28882574

NCBI chr 1:253,218,968...253,232,101

G

solute carrier family 40 member 1

decreases expression

gadolinium chloride results in decreased expression of SLC40A1

NCBI chr 9:55,525,457...55,633,463

G

secreted phosphoprotein 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695

G

sequestosome 1

multiple interactions

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750

G

sterol regulatory element binding transcription factor 1

multiple interactions

gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]

NCBI chr10:45,507,152...45,529,164

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of TGFB1 mRNA
gadolinium chloride results in increased expression of TGFB1 protein
gadolinium chloride results in increased expression of TGFB1 mRNA
gadolinium chloride affects the expression of TGFB1 mRNA

PMID:11408273 PMID:15590129 PMID:15964588 PMID:19404939 PMID:34878122

NCBI chr 1:90,324,312...90,340,627

G

toll-like receptor 4

multiple interactions

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]

PMID:25813056 PMID:26177832

NCBI chr 5:85,161,247...85,174,882

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
gadolinium trichloride inhibits the reaction [estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver]]
gadolinium chloride inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
gadolinium chloride results in increased expression of TNF
gadolinium chloride results in increased expression of TNF mRNA

CTD
RGD

PMID:12127824 PMID:12963478 PMID:14687926 PMID:15025948 PMID:15590129 More...

NCBI chr20:3,626,685...3,629,303

G

TNF receptor superfamily member 11B

increases expression

gadolinium chloride results in increased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324

G

TNF receptor superfamily member 1A

increases expression

gadolinium chloride results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817

G

TNF superfamily member 10

increases expression

gadolinium chloride results in increased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903

G

TNF superfamily member 11

decreases expression

gadolinium chloride results in decreased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479

G

uncoupling protein 2

multiple interactions

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]

NCBI chr 1:164,251,373...164,257,742

G

vascular endothelial growth factor A

increases expression

gadolinium chloride results in increased expression of VEGFA mRNA; gadolinium chloride results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194

G

X-box binding protein 1

increases splicing

gadolinium chloride results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707

motexafin gadolinium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
motexafin gadolinium results in decreased expression of AGL mRNA

NCBI chr 2:207,389,949...207,445,959

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]
motexafin gadolinium results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ALDH6A1 mRNA
Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]

NCBI chr 6:109,809,092...109,829,725

G

Rho GTPase activating protein 17

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ARHGAP17 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:187,238,675...187,328,093

G

activating transcription factor 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]
motexafin gadolinium results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653

G

ATM serine/threonine kinase

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]
motexafin gadolinium results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040

G

ATR serine/threonine kinase

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ATR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742

G

BTB domain and CNC homolog 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BACH1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118

G

BAG cochaperone 3

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]
motexafin gadolinium results in increased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281

G

Bcl-2 binding component 3

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:86,141,450...86,150,666

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]
motexafin gadolinium results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069

G

BCL2 interacting protein 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BNIP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

increases expression
multiple interactions

motexafin gadolinium results in increased expression of BNIP3L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730

G

calnexin

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866

G

caspase 3

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794

G

core-binding factor subunit beta

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:33,049,162...33,092,752

G

cyclin J

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
motexafin gadolinium results in decreased expression of CCNJ mRNA

NCBI chr 1:249,608,991...249,626,798

G

cell division cycle 16

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDC16 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA

NCBI chr16:82,475,234...82,498,797

G

cell division cycle 25C

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDC25C mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292

G

cell division cycle 27

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816

G

cell division cycle 5-like

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453

G

cell division cycle associated 2

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CDCA2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524

G

cyclin-dependent kinase 19

increases expression

motexafin gadolinium results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629

G

cyclin dependent kinase 2

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]
motexafin gadolinium results in increased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CDKN1B mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500

G

cystathionine gamma-lyase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066

G

cullin 3

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of CUL3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA

NCBI chr 9:89,040,987...89,118,775

G

cytochrome b5 reductase 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA
motexafin gadolinium results in increased expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458

G

death-associated protein kinase 3

multiple interactions
decreases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]
motexafin gadolinium results in decreased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]
motexafin gadolinium results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517

G

DNA-damage-inducible transcript 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DDIT4 mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:28,434,938...28,437,037

G

death effector domain containing 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]
motexafin gadolinium results in increased expression of DEDD2 mRNA

NCBI chr 1:89,916,906...89,934,663

G

DNA fragmentation factor subunit beta

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of DFFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157

G

7-dehydrocholesterol reductase

decreases expression

motexafin gadolinium results in decreased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]
motexafin gadolinium results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DNAJB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression
multiple interactions

motexafin gadolinium results in increased expression of DNAJB6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]
motexafin gadolinium results in increased expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643

G

E2F transcription factor 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA
motexafin gadolinium results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of E2F3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681

G

elongator acetyltransferase complex subunit 1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of ELP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA

NCBI chr 5:76,248,545...76,300,985

G

enolase 1

increases expression

motexafin gadolinium results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252

G

Fas associated via death domain

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of FADD mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423

G

Fas apoptotic inhibitory molecule

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of FAIM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499

G

family with sequence similarity 162, member A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of FAM162A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA

NCBI chr11:64,680,978...64,709,865

G

fatty acid synthase

decreases expression

motexafin gadolinium results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581

G

forkhead box O3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of FOXO3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA
motexafin gadolinium results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192

G

glutaminase

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of GLS mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900

G

G protein-coupled receptor 146

increases expression

motexafin gadolinium results in increased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122

G

glutamic--pyruvic transaminase 2

increases expression

motexafin gadolinium results in increased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551

G

glutathione peroxidase 1

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588

G

glutathione-disulfide reductase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of GSR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742

G

general transcription factor IIIC subunit 2

increases expression

motexafin gadolinium results in increased expression of GTF3C2 mRNA

NCBI chr 6:25,196,439...25,221,338

G

HMG-box transcription factor 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA
motexafin gadolinium results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
motexafin gadolinium results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068

G

hypoxia inducible lipid droplet-associated

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HILPDA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]
motexafin gadolinium results in increased expression of HIPK1 mRNA

NCBI chr 2:191,248,817...191,299,787

G

helicase-like transcription factor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
motexafin gadolinium results in decreased expression of HLTF mRNA

NCBI chr 2:102,549,724...102,609,492

G

heme oxygenase 1

multiple interactions
increases expression

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
motexafin gadolinium results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823

G

harakiri, BCL2 interacting protein

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA
motexafin gadolinium results in increased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
motexafin gadolinium results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,875,411...3,877,866

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,859,756...3,863,800

G

heat shock protein family A (Hsp70) member 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994

G

heat shock protein family A (Hsp70) member 4 like

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPA4L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]
motexafin gadolinium results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]
motexafin gadolinium results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332

G

heat shock protein family H (Hsp110) member 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of HSPH1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:10,427,368...10,446,602

G

inhibitor of DNA binding 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of ID2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression
multiple interactions

motexafin gadolinium results in increased expression of IKBKE mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA

NCBI chr13:45,264,404...45,290,737

G

interferon regulatory factor 2 binding protein 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of IRF2BP2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

motexafin gadolinium results in increased expression of JUND mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771

G

lysine demethylase 3A

increases expression

motexafin gadolinium results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073

G

MDM2 proto-oncogene

increases expression
multiple interactions

motexafin gadolinium results in increased expression of MDM2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:55,176,558...55,201,757

G

MOB kinase activator 1A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:115,831,581...115,848,561

G

metallothionein 1

multiple interactions

[Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA

NCBI chr19:10,831,959...10,832,975

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
motexafin gadolinium results in increased expression of MT1E mRNA

PMID:15867382 PMID:16357179

NCBI chr17:79,695,812...79,696,200

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]
motexafin gadolinium results in increased expression of MT1HL1 mRNA

PMID:15867382 PMID:16357179

NCBI chr20:3,159,037...3,159,409

G

metallothionein 2A

multiple interactions
increases expression

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]
motexafin gadolinium results in increased expression of MT2A mRNA

PMID:15867382 PMID:16357179

NCBI chr19:10,837,934...10,838,708

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA
motexafin gadolinium results in decreased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230

G

NAD kinase

increases expression
multiple interactions

motexafin gadolinium results in increased expression of NADK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA

NCBI chr 5:166,145,708...166,176,328

G

neurofibromin 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA
motexafin gadolinium results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086

G

nischarin

decreases expression

motexafin gadolinium results in decreased expression of NISCH mRNA

NCBI chr16:6,364,370...6,400,675

G

nuclear receptor subfamily 1, group D, member 2

increases expression
multiple interactions

motexafin gadolinium results in increased expression of NR1D2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:9,955,034...9,981,329

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]
motexafin gadolinium results in increased expression of P4HB mRNA

NCBI chr10:106,335,300...106,346,911

G

programmed cell death 11

decreases expression

motexafin gadolinium results in decreased expression of PDCD11 mRNA

NCBI chr 1:245,980,840...246,021,999

G

programmed cell death 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PDCD4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581

G

programmed cell death 5

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of PDCD5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PFKFB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PFKFB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478

G

phosphoglycerate kinase 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:71,271,454...71,287,429

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]
motexafin gadolinium results in increased expression of PHTF2 mRNA

NCBI chr 4:14,215,190...14,330,549

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]
motexafin gadolinium results in increased expression of PIAS1 mRNA

NCBI chr 8:63,338,150...63,451,670

G

phosphoinositide-3-kinase interacting protein 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of PIK3IP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA
motexafin gadolinium results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
motexafin gadolinium results in increased expression of PRKACB mRNA

NCBI chr 2:235,636,878...235,726,928

G

protein kinase C, delta

decreases expression

motexafin gadolinium results in decreased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122

G

protein kinase D2

decreases expression

motexafin gadolinium results in decreased expression of PRKD2 mRNA

NCBI chr 1:86,640,095...86,670,476

G

protein kinase, DNA-activated, catalytic subunit

increases expression

motexafin gadolinium results in increased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499

G

peptidyl-tRNA hydrolase 2

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of PTRH2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA

NCBI chr10:71,505,113...71,515,297

G

RB transcriptional corepressor 1

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of RB1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
motexafin gadolinium results in decreased expression of RCBTB2 mRNA

NCBI chr15:48,319,809...48,364,441

G

RELB proto-oncogene, NF-kB subunit

increases expression
multiple interactions

motexafin gadolinium results in increased expression of RELB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380

G

ring finger protein 19B

increases expression

motexafin gadolinium results in increased expression of RNF19B mRNA

NCBI chr 5:146,690,453...146,715,729

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
motexafin gadolinium results in increased expression of SAMTOR mRNA

NCBI chr 4:41,881,630...41,945,472

G

selenoprotein W

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
motexafin gadolinium results in increased expression of SELENOW mRNA

NCBI chr 1:76,599,441...76,604,514

G

sestrin 2

multiple interactions
increases expression

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
motexafin gadolinium results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:149,986,304...150,005,255

G

solute carrier family 16 member 1

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]
motexafin gadolinium results in increased expression of SLC16A1 mRNA

NCBI chr 2:194,805,556...194,832,966

G

solute carrier family 16, member 6

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA
motexafin gadolinium results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482

G

solute carrier family 1 member 4

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]
motexafin gadolinium results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190

G

solute carrier family 30 member 1

multiple interactions
increases expression

[Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

PMID:15867382 PMID:16357179

NCBI chr13:106,022,019...106,025,892

G

solute carrier family 38, member 2

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 10

multiple interactions
affects expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA
motexafin gadolinium affects the expression of SLC39A10 mRNA

NCBI chr 9:54,836,841...54,960,325

G

solute carrier family 39 member 14

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC39A14 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549

G

solute carrier family 39, member 9

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC39A9 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA

NCBI chr 6:100,291,537...100,330,419

G

solute carrier family 3 member 2

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
motexafin gadolinium results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064

G

solute carrier family 43 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
motexafin gadolinium results in increased expression of SLC43A1 mRNA

NCBI chr 3:69,920,586...69,946,768

G

solute carrier family 7 member 1

multiple interactions
increases expression

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
motexafin gadolinium results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030

G

solute carrier family 7 member 11

increases expression
multiple interactions

motexafin gadolinium results in increased expression of SLC7A11 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of SMARCA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA

NCBI chr 8:20,167,717...20,258,975

G

SNF2 related chromatin remodeling ATPase 5

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of SMARCA5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594

G

T-cell activation RhoGTPase activating protein

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TAGAP mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA

NCBI chr 1:47,170,725...47,179,705

G

transferrin receptor

multiple interactions
increases expression

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]
motexafin gadolinium results in increased expression of TFRC mRNA

NCBI chr11:81,668,478...81,690,318

G

TNF alpha induced protein 8

decreases expression
multiple interactions

motexafin gadolinium results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:45,370,334...45,486,036

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
motexafin gadolinium results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817

G

TNF superfamily member 8

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]
motexafin gadolinium results in increased expression of TNFSF8 mRNA

NCBI chr 5:77,250,942...77,277,364

G

TNFAIP3 interacting protein 2

decreases expression

motexafin gadolinium results in decreased expression of TNIP2 mRNA

NCBI chr14:80,452,936...80,470,141

G

tumor protein p53

multiple interactions

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300

G

tribbles pseudokinase 3

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TRIB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533

G

thioredoxin reductase 1

increases expression
multiple interactions

motexafin gadolinium results in increased expression of TXNRD1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553

G

vascular endothelial growth factor A

increases expression
multiple interactions

motexafin gadolinium results in increased expression of VEGFA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194

G

von Hippel-Lindau tumor suppressor

multiple interactions
increases expression

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]
motexafin gadolinium results in increased expression of VHL mRNA

NCBI chr 4:148,328,099...148,334,992

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
chemical entity	19896
molecular entity	19895
transition element molecular entity	17453
f-block molecular entity	413
lanthanoid molecular entity	413
lanthanoid coordination entity	320
cerium coordination entity +	100
europium coordination entity +	0
gadolinium coordination entity +	243
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
metal atom	18051
transition element atom	17591
transition element molecular entity	17453
f-block molecular entity	413
lanthanoid molecular entity	413
lanthanoid coordination entity	320
cerium coordination entity +	100
europium coordination entity +	0
gadolinium coordination entity +	243

paths to the root