sulfated glycosaminoglycan - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	sulfated glycosaminoglycan	go back to main search page
Accession:	CHEBI:35722	browse the term
Synonyms:	related_synonym:	glycosaminoglycan sulfate; glycosaminoglycan sulfates; sulfated glycosaminoglycans

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Rat (191) Mouse (190) Human (192) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (6) Green Monkey (0) Naked Mole-rat (0) All
Genes (191)

chondroitin sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arylsulfatase B

decreases abundance

ARSB protein results in decreased abundance of Chondroitin Sulfates

NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671

G

bradykinin receptor B2

multiple interactions

[icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

complement C3

increases cleavage

Chondroitin Sulfates analog results in increased cleavage of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

increases cleavage

Chondroitin Sulfates analog results in increased cleavage of C5 protein

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

caspase 3

multiple interactions

[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

Chondroitin Sulfates inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:12736501 PMID:15089041

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

affects binding

Chondroitin Sulfates binds to CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cathepsin B

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]; Chondroitin Sulfates promotes the reaction [CTSB protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin K

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL3 protein]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cathepsin L

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cathepsin S

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein]

NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483

G

C-X-C motif chemokine ligand 1

multiple interactions

Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSK protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL10 protein]; Chondroitin Sulfates inhibits the reaction [CTSS protein results in increased degradation of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL11 protein]; Chondroitin Sulfates inhibits the reaction [CTSL protein results in increased degradation of CXCL11 protein]

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 2

multiple interactions

Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL2 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

Chondroitin Sulfates promotes the reaction [CTSK protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSL protein results in increased cleavage of CXCL1 protein]; Chondroitin Sulfates promotes the reaction [CTSS protein results in increased cleavage of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 9

multiple interactions

Chondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

coagulation factor XII

increases activity

Chondroitin Sulfates analog results in increased activity of F12 protein

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

fibroblast growth factor 10

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein; Chondroitin Sulfates analog binds to FGF10 protein

PMID:12221095 PMID:15385557

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 16

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein; Chondroitin Sulfates analog binds to FGF16 protein

PMID:12221095 PMID:15385557

NCBI chr X:70,816,658...70,828,028
Ensembl chr X:70,817,433...70,878,717

G

fibroblast growth factor 18

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein; Chondroitin Sulfates analog binds to FGF18 protein

PMID:12221095 PMID:15385557

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 2

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein; Chondroitin Sulfates analog binds to FGF2 protein

PMID:12221095 PMID:15385557

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 23

increases activity

Chondroitin Sulfates analog results in increased activity of FGF23 protein

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

glial cell derived neurotrophic factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

heparin-binding EGF-like growth factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein; Chondroitin Sulfates analog binds to HBEGF protein

PMID:12221095 PMID:15385557

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

interleukin 1 beta

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein; [Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Dinoprostone]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

inter-alpha trypsin inhibitor, heavy chain 1

multiple interactions

TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates]

NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363

G

kallikrein B1

increases activity

Chondroitin Sulfates analog results in increased activity of KLKB1 protein

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

midkine

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein; Chondroitin Sulfates analog binds to MDK protein

PMID:12221095 PMID:15385557

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

matrix metallopeptidase 3

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

myeloperoxidase

multiple interactions

[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nuclear factor kappa B subunit 1

multiple interactions

[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of NOS2 protein

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

platelet derived growth factor subunit B

multiple interactions

Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor beta

multiple interactions

Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

prostaglandin E synthase

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGES protein

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pleiotrophin

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein; Chondroitin Sulfates analog binds to PTN protein

PMID:12221095 PMID:15385557

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

protein tyrosine phosphatase, non-receptor type 11

affects binding

PTPN11 protein binds to Chondroitin Sulfates

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

TIMP metallopeptidase inhibitor 3

multiple interactions

[Glucosamine co-treated with Chondroitin Sulfates co-treated with IL1B protein] results in increased expression of TIMP3 mRNA

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

tumor necrosis factor

multiple interactions

[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of TNF

PMID:14697411 PMID:20110869

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 6

multiple interactions

TNFAIP6 protein promotes the reaction [ITIH1 protein binds to Chondroitin Sulfates]

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

TNF receptor superfamily member 11B

multiple interactions
increases expression

[Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine co-treated with Cholecalciferol] results in increased expression of TNFRSF11B protein; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B mRNA; [Chondroitin Sulfates co-treated with Glucosamine] results in increased expression of TNFRSF11B protein
Chondroitin Sulfates results in increased expression of TNFRSF11B protein

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

multiple interactions
decreases expression

[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Glucosamine results in increased expression of TNFSF11 mRNA]
Chondroitin Sulfates results in decreased expression of TNFSF11 mRNA

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

vascular endothelial growth factor A

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

dermatan sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

coagulation factor II, thrombin

multiple interactions

[Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fibroblast growth factor 10

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 16

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF16 protein

NCBI chr X:70,816,658...70,828,028
Ensembl chr X:70,817,433...70,878,717

G

fibroblast growth factor 18

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 2

affects binding
increases activity

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein
Dermatan Sulfate analog results in increased activity of FGF2 protein

PMID:15385557 PMID:15563459

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 23

increases activity

Dermatan Sulfate analog results in increased activity of FGF23 protein

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

fibroblast growth factor 7

increases activity

Dermatan Sulfate analog results in increased activity of FGF7 protein

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

glial cell derived neurotrophic factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to GDNF protein

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

heparin-binding EGF-like growth factor

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to HBEGF protein

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

midkine

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

platelet derived growth factor receptor alpha

decreases expression

Dermatan Sulfate results in decreased expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

decreases expression

Dermatan Sulfate results in decreased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pleiotrophin

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

serpin family D member 1

multiple interactions

[Dermatan Sulfate co-treated with SERPIND1 protein] results in decreased activity of F2 protein

NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519

G

vascular endothelial growth factor A

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

heparan sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 5

multiple interactions

Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of [CCL5 protein binds to CCL5 protein]]; Heparitin Sulfate inhibits the reaction [Hydrogen Peroxide results in increased degradation of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-X-C motif chemokine ligand 1

multiple interactions

CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

multiple interactions

CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

multiple interactions

CXCL10 protein inhibits the reaction [CXCL1 protein binds to Heparitin Sulfate]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

fibroblast growth factor 1

affects binding

FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 10

affects activity

Heparitin Sulfate affects the activity of FGF10 protein

PMID:12781692 PMID:12818887

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 2

multiple interactions
affects binding
increases activity

Heparitin Sulfate binds to and affects the activity of FGF2 protein
Heparitin Sulfate binds to FGF2 protein
Heparitin Sulfate analog results in increased activity of FGF2 protein

PMID:12460940 PMID:15464572 PMID:15958608

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 4

affects binding

Heparitin Sulfate binds to FGF4 protein

NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466

G

fibroblast growth factor 7

affects binding

Heparitin Sulfate binds to FGF7 protein

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

fibroblast growth factor 8

affects binding
increases activity

Heparitin Sulfate binds to FGF8 protein alternative form
Heparitin Sulfate analog results in increased activity of FGF8 protein

PMID:12460940 PMID:15769253

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

Fibroblast growth factor receptor 1

affects binding
increases activity

FGF1 protein binds to Heparitin Sulfate binds to FGFR1 protein
Heparitin Sulfate analog results in increased activity of FGFR1 protein alternative form

PMID:12460940 PMID:12604602

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

decreases activity

Heparitin Sulfate analog results in decreased activity of FGFR2 protein mutant form

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

increases activity

Heparitin Sulfate analog results in increased activity of FGFR3 protein alternative form

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

affects binding

Heparitin Sulfate analog binds to FGFR4 protein

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

glucosamine (N-acetyl)-6-sulfatase

affects degradation

GNS affects the degradation of Heparitin Sulfate

NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151

G

glypican 1

affects binding
multiple interactions

GPC1 protein binds to Heparitin Sulfate
GPC1 protein modified form results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]; nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]; Zinc affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]]

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

heparanase

multiple interactions
decreases abundance
affects abundance

[Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate; [phosphomannopentaose sulfate results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate
HPSE protein results in decreased abundance of Heparitin Sulfate
HPSE protein affects the abundance of Heparitin Sulfate

PMID:16899518 PMID:17121850

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

mitogen activated protein kinase 1

multiple interactions

Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

N-deacetylase and N-sulfotransferase 1

multiple interactions

Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein]

NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191

G

N-deacetylase and N-sulfotransferase 2

multiple interactions

Heparitin Sulfate affects the susceptibility to [NDST1 protein co-treated with NDST2 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK1 protein]; Heparitin Sulfate inhibits the reaction [[NDST1 protein co-treated with NDST2 protein] affects the phosphorylation of MAPK3 protein]

NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801

G

prion protein

affects binding

PRNP protein modified form binds to Heparitin Sulfate metabolite

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

TIMP metallopeptidase inhibitor 3

multiple interactions

[N6L peptide binds to Heparitin Sulfate] which results in increased secretion of TIMP3 protein

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

vascular endothelial growth factor A

multiple interactions

Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

heparin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

affects activity
multiple interactions

Heparin affects the activity of ABCC1 protein
Heparin affects the reaction [ABCC1 protein affects the transport of Doxorubicin]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

atypical chemokine receptor 3

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA]

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

actin alpha 2, smooth muscle

multiple interactions

Heparin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin related protein 3

increases expression

Heparin results in increased expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA]

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

angiotensinogen

multiple interactions

Heparin inhibits the reaction [AGT protein affects the localization of Calcium]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

multiple interactions

Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

annexin A6

increases expression

Heparin results in increased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

amyloid P component, serum

increases expression

Heparin results in increased expression of APCS protein

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

amyloid beta precursor protein

multiple interactions

Copper promotes the reaction [Heparin binds to APP protein]; Zinc promotes the reaction [Heparin binds to APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

Rho GDP dissociation inhibitor alpha

increases expression

Heparin results in increased expression of ARHGDIA protein

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA]

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Heparin results in increased expression of BAX protein
Heparin inhibits the reaction [arsenite results in increased expression of BAX protein]

PMID:11787776 PMID:26677073

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions

Heparin results in increased expression of BCL2 protein
Heparin inhibits the reaction [arsenite results in decreased expression of BCL2 protein]

PMID:11787776 PMID:15205081 PMID:15671997 PMID:26677073

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 6

multiple interactions
decreases expression

Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]
Heparin results in decreased expression of BMP6 mRNA

NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365

G

bone morphogenetic protein receptor type 1A

decreases expression

Heparin results in decreased expression of BMPR1A mRNA

NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616

G

complement C3

decreases expression

Heparin results in decreased expression of C3 protein

PMID:7948777 PMID:10568115

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C5

decreases expression

Heparin results in decreased expression of C5 protein

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

calcium voltage-gated channel subunit alpha1 E

multiple interactions

Heparin affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

G

capping actin protein, gelsolin like

increases expression

Heparin results in increased expression of CAPG protein

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calpain 1

multiple interactions

Heparin inhibits the reaction [Paraoxon results in increased expression of CAPN1 protein]

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

calpain 2

multiple interactions

Heparin inhibits the reaction [Paraoxon results in increased expression of CAPN2 protein]

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caspase 12

multiple interactions

Heparin inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP12 protein]; Heparin inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]

PMID:20079824 PMID:26998625

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

decreases activity
multiple interactions

Heparin results in decreased activity of CASP3 protein
Heparin inhibits the reaction [Paraoxon results in increased expression of and affects the activity of CASP3 protein]
Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]

PMID:16556679 PMID:26998625 PMID:30377735

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

increases activity

Heparin results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 11

affects binding
multiple interactions

Heparin binds to CCL11 protein
Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

decreases expression

Heparin results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

CD40 ligand

decreases expression

Heparin results in decreased expression of CD40LG protein

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

cyclin-dependent kinase inhibitor 1A

increases expression

Heparin results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression
increases expression

Heparin analog results in decreased expression of CDKN1B protein
Heparin analog results in increased expression of CDKN1B protein

PMID:18057711 PMID:20201787

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

collagen type XVIII alpha 1 chain

affects binding

Heparin binds to COL18A1 protein alternative form

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

C-reactive protein

increases expression

Heparin results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 3

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

catenin beta 1

multiple interactions

Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [Heparin promotes the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 10

multiple interactions

Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CXCL10 mRNA]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

Heparin analog results in decreased expression of CXCL12 mRNA; Heparin analog results in decreased expression of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 4

decreases expression

Heparin analog results in decreased expression of CXCR4 mRNA; Heparin analog results in decreased expression of CXCR4 protein

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DDAH family member 2, ADMA-independent

decreases expression

Heparin results in decreased expression of DDAH2 protein

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

desmin

decreases expression

Heparin results in decreased expression of DES protein

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

E2F transcription factor 1

decreases expression

Heparin analog results in decreased expression of E2F1 protein

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

endothelin 1

multiple interactions
decreases expression
decreases secretion

Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in decreased expression of EDN1 mRNA
Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
Heparin results in decreased secretion of EDN1 protein

PMID:1443220 PMID:7509996 PMID:8408661

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor

decreases activity

Heparin results in decreased activity of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression
increases phosphorylation

Heparin results in decreased expression of EGFR mRNA; Heparin results in decreased expression of EGFR protein
Heparin results in increased phosphorylation of EGFR protein

PMID:16475731 PMID:16556679

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA]

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

coagulation factor X

decreases activity

Heparin results in decreased activity of F10 protein

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II, thrombin

multiple interactions
decreases expression
increases expression

F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]; Heparin deficiency results in increased cleavage of and results in increased activity of F2 protein; Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]; Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]; Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA]; Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein]
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin results in decreased expression of F2 protein
Heparin deficiency results in increased expression of F2 protein; Heparin results in increased expression of F2 protein

PMID:7509996 PMID:7895349 PMID:8408661 PMID:9740346 PMID:11869846 More...

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor II (thrombin) receptor

multiple interactions

Heparin inhibits the reaction [F2 protein results in increased cleavage of F2R protein]

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

Fas cell surface death receptor

increases expression

Heparin results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fc gamma receptor 2A

affects binding

[Heparin binds to PF4 protein] which binds to FCGR2A protein

NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967

G

fibrinogen alpha chain

increases cleavage

Heparin deficiency results in increased cleavage of FGA protein

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 1

multiple interactions
affects binding

[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin analog promotes the reaction [FGF1 protein binds to FGF1 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin promotes the reaction [FGF1 protein results in increased expression of FGF1 protein]
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]

PMID:1379594 PMID:8576258 PMID:10336501 PMID:10860838 PMID:14966081 More...

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 10

multiple interactions

Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein]

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 19

affects binding
multiple interactions

Heparin binds to FGF19 protein
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]

PMID:10525310 PMID:14730967

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

fibroblast growth factor 2

affects binding
decreases expression
multiple interactions
affects activity

Heparin binds to FGF2 protein; Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin results in decreased expression of FGF2 protein
[Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein
Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin affects the activity of FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]; Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]

PMID:1373495 PMID:1379594 PMID:8441232 PMID:10336501 PMID:10860838 More...

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 23

increases activity

Heparin analog results in increased activity of FGF23 protein

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

fibroblast growth factor 3

affects activity

Heparin affects the activity of FGF3 protein

NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187

G

fibroblast growth factor 4

multiple interactions

Heparin binds to and results in increased activity of FGF4 protein

NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466

G

fibroblast growth factor 5

affects activity

Heparin affects the activity of FGF5 protein

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

fibroblast growth factor 7

affects binding

[Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

Fibroblast growth factor receptor 1

affects binding
multiple interactions

Heparin binds to FGFR1 protein binds to FGF2 protein
Heparin promotes the reaction [FGFR1 protein binds to FGF1 protein]; Heparin promotes the reaction [FGFR1 protein binds to FGF2 protein]

PMID:1379594 PMID:15096041

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

multiple interactions
affects binding
affects activity

[Heparin analog binds to FGFR2 protein alternative form] which binds to and results in increased activity of FGF1 protein; Heparin promotes the reaction [FGF10 protein binds to FGFR2 protein]
[Heparin binds to FGFR2 protein alternative form] which binds to FGF1 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF2 protein; [Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein
Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]
Heparin affects the activity of FGFR2 protein

PMID:1373495 PMID:10860838 PMID:15632068 PMID:16219767

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fibroblast growth factor receptor 3

affects activity
multiple interactions

Heparin affects the activity of FGFR3 protein
Heparin promotes the reaction [FGFR3 protein binds to FGF1 protein]

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

G

fibroblast growth factor receptor 4

affects binding
multiple interactions

Heparin analog binds to FGFR4 protein
Heparin affects the reaction [FGF1 protein binds to FGFR4 protein]; Heparin affects the reaction [FGF2 protein binds to FGFR4 protein]
Heparin promotes the reaction [FGF19 protein binds to FGFR4 protein]; Heparin promotes the reaction [FGFR4 protein binds to FGFR4 protein]

PMID:10336501 PMID:10525310 PMID:10736564 PMID:11278860

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression
multiple interactions

Heparin results in increased expression of FOS protein
Heparin results in decreased expression of FOS mRNA
Heparin inhibits the reaction [4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOS mRNA]

PMID:2099192 PMID:9083085

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

GATA binding protein 4

multiple interactions

Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein]

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

glucosamine (N-acetyl)-6-sulfatase

affects degradation

GNS affects the degradation of Heparin

NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151

G

glutamic--pyruvic transaminase

multiple interactions

Heparin inhibits the reaction [Diclofenac promotes the reaction [endotoxin, Escherichia coli results in increased activity of GPT protein]]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

granzyme B

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA]

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

hepcidin antimicrobial peptide

decreases expression
decreases secretion
multiple interactions

Heparin results in decreased expression of HAMP mRNA
Heparin results in decreased secretion of HAMP protein modified form
Heparin inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]; Heparin inhibits the reaction [BMP6 protein results in increased secretion of HAMP protein modified form]; Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]

PMID:25633564 PMID:25686467

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hepatocyte growth factor

multiple interactions
affects binding
increases expression

Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein]
HGF protein binds to Heparin
Heparin results in increased expression of HGF protein

PMID:9083085 PMID:18243369

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

heme oxygenase 1

multiple interactions

Heparin inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMOX1 mRNA]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heparanase

multiple interactions

[Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

histidine-rich glycoprotein

multiple interactions

Heparin inhibits the reaction [Zinc results in increased activity of HRG protein]

NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389

G

immunoglobulin superfamily, member 10

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA]

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

interleukin 6

increases expression
increases secretion
multiple interactions

Heparin results in increased expression of IL6 protein
Heparin analog results in increased secretion of IL6 protein
Heparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]

PMID:16391376 PMID:16401727 PMID:25633564 PMID:26476401

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha M

decreases expression
increases expression

Heparin results in decreased expression of ITGAM protein
Heparin results in increased expression of ITGAM protein

PMID:8595612 PMID:8993250

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha X

decreases expression

Heparin results in decreased expression of ITGAX protein

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Heparin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 4

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

keratin 18

increases expression

Heparin results in increased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

lactate dehydrogenase B

decreases expression

Heparin results in decreased expression of LDHB protein

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

lipoprotein lipase

multiple interactions

[etofibrate co-treated with Heparin] results in increased secretion of LPL protein
Heparin results in increased expression of and results in increased activity of LPL protein

PMID:2313202 PMID:3179329

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

mitogen activated protein kinase kinase 1

multiple interactions

Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]

NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243

G

mitogen activated protein kinase 1

multiple interactions
increases activity

Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK1 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
Heparin results in increased activity of MAPK1 protein

PMID:14966081 PMID:16556679 PMID:18057711 PMID:19937756

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases activity

Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK3 protein]
Heparin inhibits the reaction [FGF1 protein results in increased phosphorylation of MAPK3 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
Heparin results in increased activity of MAPK3 protein

PMID:14966081 PMID:16556679 PMID:18057711 PMID:19937756

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

Heparin promotes the reaction [MAPT protein binds to MAPT protein]; Mercuric Chloride promotes the reaction [Heparin promotes the reaction [MAPT protein binds to MAPT protein]]

PMID:20665688 PMID:31678113

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

mast cell protease 4

increases activity

Heparin increases activity of Mcpt4 protein

RGD

NCBI chr15:29,501,595...29,504,216
Ensembl chr15:29,501,595...29,504,214

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

Heparin promotes the reaction [HGF protein binds to and results in increased activity of MET protein]

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

macrophage migration inhibitory factor

affects binding

MIF protein binds to Heparin

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

matrix metallopeptidase 1

decreases activity

Heparin results in decreased activity of MMP1 protein

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 14

decreases expression

Heparin analog results in decreased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

decreases activity

Heparin results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases activity
increases expression
multiple interactions

Heparin results in decreased activity of MMP9 protein
Heparin results in increased expression of MMP9 mRNA; Heparin results in increased expression of MMP9 protein
Heparin results in increased metabolism of and results in increased activity of MMP9 protein

PMID:10958381 PMID:14630814 PMID:16190367

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

Heparin inhibits the reaction [4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

moesin

increases expression

Heparin results in increased expression of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

MYC proto-oncogene, bHLH transcription factor

increases expression
decreases expression

Heparin results in increased expression of MYC protein
Heparin results in decreased expression of MYC mRNA

PMID:2099192 PMID:11787776 PMID:16475731

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear factor of activated T-cells 3

multiple interactions

Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein]

NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150

G

NFE2 like bZIP transcription factor 2

increases expression

Heparin analog results in increased expression of NFE2L2 mRNA

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

Parkinsonism associated deglycase

increases expression

Heparin results in increased expression of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions

Heparin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

platelet derived growth factor subunit B

affects expression

Heparin affects the expression of PDGFB protein

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

platelet derived growth factor receptor alpha

decreases expression

Heparin results in decreased expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

pyruvate dehydrogenase E1 subunit beta

decreases expression

Heparin results in decreased expression of PDHB protein

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

platelet factor 4

affects binding
increases secretion

[Heparin binds to PF4 protein] which binds to FCGR2A protein; Heparin binds to PF4 protein
Heparin results in increased secretion of PF4 protein

PMID:2437338 PMID:2709525 PMID:8282825 PMID:20162249

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

phosphatidylinositol transfer protein, alpha

increases expression

Heparin results in increased expression of PITPNA protein

NCBI chr10:60,430,712...60,473,564
Ensembl chr10:60,430,748...60,471,342

G

plasminogen activator, tissue type

increases expression

Heparin results in increased expression of PLAT mRNA; Heparin results in increased expression of PLAT protein

PMID:14630814 PMID:16190367

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

decreases expression

Heparin analog results in decreased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen

multiple interactions

Heparin inhibits the reaction [PLG protein affects the degradation of CCL11 protein]

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

pro-platelet basic protein

increases secretion

Heparin results in increased secretion of PPBP protein

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

protein C, inactivator of coagulation factors Va and VIIIa

increases activity

Heparin deficiency results in increased activity of PROC protein

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

proteasome 20S subunit beta 5

decreases activity
decreases expression

Heparin analog results in decreased activity of PSMB5 protein
Heparin analog results in decreased expression of PSMB5 mRNA

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 6

decreases expression

Heparin analog results in decreased expression of PSMB6 mRNA

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 7

decreases expression

Heparin analog results in decreased expression of PSMB7 mRNA

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

proteasome activator subunit 1

increases expression

Heparin results in increased expression of PSME1 protein

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases phosphorylation

Heparin results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

paxillin

decreases phosphorylation

Heparin results in decreased phosphorylation of PXN protein

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

Rac family small GTPase 1

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RB transcriptional corepressor 1

multiple interactions

Heparin analog results in decreased expression of and results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Heparin inhibits the reaction [arsenite affects the localization of RELA protein]; Heparin inhibits the reaction [TNF protein affects the localization of RELA protein]

PMID:10843908 PMID:26677073

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A1

affects expression

Heparin affects the expression of S100A1 protein

NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544

G

S100 calcium binding protein A6

affects expression
increases expression

Heparin affects the expression of S100A6 protein
Heparin results in increased expression of S100A6 protein

PMID:12186470 PMID:17488504

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein B

affects expression

Heparin affects the expression of S100B protein

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

syndecan 1

decreases expression

Heparin analog results in decreased expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

syndecan 2

decreases expression

Heparin analog results in decreased expression of SDC2 mRNA

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

syndecan 4

increases expression

Heparin analog results in increased expression of SDC4 mRNA

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

selectin L

decreases expression
increases expression

Heparin results in decreased expression of SELL protein
Heparin results in increased expression of SELL protein

PMID:8595612 PMID:8993250

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

selectin P

multiple interactions
increases expression

Heparin inhibits the reaction [F2 protein affects the localization of SELP protein]; Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein]
Heparin results in increased expression of SELP protein

PMID:9740346 PMID:10544909

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

septin 2

increases expression

Heparin results in increased expression of SEPTIN2 protein

NCBI chr 9:94,018,141...94,051,386
Ensembl chr 9:94,018,208...94,051,386

G

serpin family C member 1

decreases expression
multiple interactions

Heparin deficiency results in decreased expression of SERPINC1 protein; Heparin results in decreased expression of SERPINC1 protein
Heparin results in increased expression of [F2 protein binds to SERPINC1 protein]
Heparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]

PMID:73932 PMID:7895349 PMID:8122184 PMID:11869846 PMID:16961586

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

serpin family E member 1

multiple interactions

Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

secreted frizzled-related protein 1

multiple interactions

Heparin promotes the reaction [Doxorubicin results in increased secretion of SFRP1 protein]

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

solute carrier family 5 member 3

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA]

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

STE20-like kinase

multiple interactions

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA]

NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530

G

stress-induced phosphoprotein 1

increases expression

Heparin results in increased expression of STIP1 protein

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

transgelin 2

decreases expression

Heparin results in decreased expression of TAGLN2 protein

NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972

G

transferrin receptor

multiple interactions
decreases expression

Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]
Heparin results in decreased expression of TFRC protein

PMID:16401727 PMID:25633564

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

decreases expression

Heparin results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions
increases expression

Heparin inhibits the reaction [TNF protein affects the localization of RELA protein]
Heparin results in increased expression of TNF protein

PMID:10843908 PMID:17162433

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

decreases expression

Heparin analog results in decreased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

affects binding

Heparin binds to VEGFA protein alternative form

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

keratan sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

increases chemical synthesis

B3GNT2 protein results in increased chemical synthesis of Keratan Sulfate

NCBI chr14:96,808,473...96,833,674
Ensembl chr14:96,806,664...96,835,273

G

beta-1,4-galactosyltransferase 1

increases chemical synthesis

B4GALT1 protein results in increased chemical synthesis of Keratan Sulfate

NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461

G

carbohydrate sulfotransferase 5

multiple interactions

CHST6 protein results in increased sulfation of and results in increased chemical synthesis of Keratan Sulfate

NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064

G

glucosamine (N-acetyl)-6-sulfatase

affects degradation

GNS affects the degradation of Keratan Sulfate

NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151

Laurolactam

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

laurolactam binds to and results in decreased activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

estrogen receptor 1

multiple interactions

laurolactam binds to and results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

laurolactam binds to and results in decreased activity of NR3C1 protein

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

progesterone receptor

multiple interactions

laurolactam binds to and results in decreased activity of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

Mycotrienin I

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

intercellular adhesion molecule 1

multiple interactions

mycotrienin I inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

tumor necrosis factor

multiple interactions

mycotrienin I inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
role	19837
chemical role	19467
catalyst	8303
sulfuric acid	8253
sulfuric acid derivative	8253
organic sulfate	2289
carbohydrate sulfate	1768
sulfated glycosaminoglycan	191
[4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n	0
[4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n	0
chondroitin sulfate +	49
dermatan 6'-sulfate	0
dermatan sulfate	16
heparan sulfates +	24
heparin glucosamine 3-O-sulfate	0
heparins +	143
heparitins +	0
keratan sulfate +	10
keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine	0
proteochondroitin sulfate	0
Path 2
Term	Annotations
CHEBI ontology	19867
subatomic particle	19865
composite particle	19865
hadron	19865
baryon	19865
nucleon	19865
atomic nucleus	19865
atom	19865
main group element atom	19803
p-block element atom	19803
carbon group element atom	19744
carbon atom	19740
organic molecular entity	19740
heteroorganic entity	19512
organochalcogen compound	19273
organooxygen compound	19189
carbohydrates and carbohydrate derivatives	15289
carbohydrate	15289
polysaccharide	8221
polysaccharide derivative	5131
aminoglycan	415
glycosaminoglycan	377
sulfated glycosaminoglycan	191
[4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNAc6OS-(1->]n	0
[4)-beta-D-GlcpA-(1->4)-alpha-D-GlcpNS6OS-(1->]n	0
chondroitin sulfate +	49
dermatan 6'-sulfate	0
dermatan sulfate	16
heparan sulfates +	24
heparin glucosamine 3-O-sulfate	0
heparins +	143
heparitins +	0
keratan sulfate +	10
keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine	0
proteochondroitin sulfate	0

paths to the root