dicarboxylic acid anion - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dicarboxylic acid anion	go back to main search page
Accession:	CHEBI:35693	browse the term
Synonyms:	related_synonym:	dicarboxylic acid anions
	cyclic_relationship:	is_conjugate_base_of CHEBI:35692

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Rat (253) Mouse (254) Human (260) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (253)

calcium oxalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases cleavage

SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
decreases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions

Calcium Oxalate results in decreased expression of CCL2 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CCL2 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CCL2 protein]

PMID:37414240 PMID:37454925

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

CD44 molecule

multiple interactions
decreases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of CD44 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CD44 protein]

PMID:37414240 PMID:37454925

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cytochrome b-245 beta chain

multiple interactions
increases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX2 protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 2, subfamily c, polypeptide 7

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of CYP2C9 mRNA]

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

histone deacetylase 1

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC1 mRNA]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC2 mRNA]

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 3

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC3 mRNA]

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

histone deacetylase 8

multiple interactions

[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of HDAC8 mRNA]

NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923

G

heme oxygenase 1

multiple interactions
increases expression

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

inositol 1,4,5-trisphosphate receptor, type 1

increases expression
multiple interactions

Calcium Oxalate results in increased expression of ITPR1 protein
Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein]

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

inositol 1,4,5-trisphosphate receptor, type 2

multiple interactions
increases expression

Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein]

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

inositol 1,4,5-trisphosphate receptor, type 3

increases expression

Calcium Oxalate results in increased expression of ITPR3 protein

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

NADPH oxidase 4

increases expression
multiple interactions

Calcium Oxalate results in increased expression of NOX4 protein
2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

sirtuin 1

multiple interactions
decreases expression

phenyl-N-tert-butylnitrone inhibits the reaction [Calcium Oxalate results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in decreased expression of BCL2 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased cleavage of CASP3 protein]; SIRT1 protein inhibits the reaction [Calcium Oxalate results in increased expression of BAX protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 1

multiple interactions
decreases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

secreted phosphoprotein 1

multiple interactions
decreases expression

2-aminoethyl diphenylborinate inhibits the reaction [Calcium Oxalate results in decreased expression of SPP1 protein]; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA; [Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 mRNA]; Butyric Acid inhibits the reaction [[Ethylene Glycol co-treated with Calcium Oxalate] results in increased expression of SPP1 protein]

PMID:37414240 PMID:37454925

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

carboplatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

Carboplatin results in decreased expression of ABCB1 mRNA; Carboplatin results in decreased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

decreases expression

Carboplatin results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

decreases expression

Carboplatin results in decreased expression of ABCC1 mRNA; Carboplatin results in decreased expression of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases expression

Carboplatin results in decreased expression of ABCC2 mRNA; Carboplatin results in decreased expression of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

decreases expression

Carboplatin results in decreased expression of ABCG2 mRNA; Carboplatin results in decreased expression of ABCG2 protein

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

activin A receptor type 1C

increases response to substance

ACVR1C results in increased susceptibility to Carboplatin

NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327

G

aryl hydrocarbon receptor

decreases expression

Carboplatin results in decreased expression of AHR mRNA

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B1

increases expression

Carboplatin results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

multiple interactions

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]; Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]

PMID:18483861 PMID:33190582

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

5'-aminolevulinate synthase 2

decreases expression

Carboplatin results in decreased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

aldehyde dehydrogenase 1 family, member A1

affects response to substance

ALDH1A1 protein affects the susceptibility to Carboplatin

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 3 family, member A1

affects response to substance

ALDH3A1 protein affects the susceptibility to Carboplatin

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

annexin A4

decreases response to substance
affects localization
multiple interactions

ANXA4 protein results in decreased susceptibility to Carboplatin
Carboplatin affects the localization of ANXA4 protein
ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

ARF guanine nucleotide exchange factor 1

increases response to substance

ARFGEF1 results in increased susceptibility to Carboplatin

NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326

G

ARF like GTPase 4C

affects response to substance

ARL4C protein affects the susceptibility to Carboplatin

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

G

ATPase Na+/K+ transporting subunit alpha 1

decreases expression

Carboplatin results in decreased expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase copper transporting alpha

affects localization
multiple interactions

Carboplatin affects the localization of ATP7A protein
[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]

PMID:24038379 PMID:24150977

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

multiple interactions

ATP7B protein binds to and results in increased metabolism of Carboplatin

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression
multiple interactions

Carboplatin results in decreased expression of BAX mRNA
Carboplatin results in increased expression of BAX mRNA; Carboplatin results in increased expression of BAX protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; Carboplatin results in increased cleavage of and results in increased expression of BAX protein

PMID:15131059 PMID:15576332 PMID:33002289

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Carboplatin results in decreased expression of BCL2 mRNA; Carboplatin results in decreased expression of BCL2 protein

PMID:9664115 PMID:15576332 PMID:15996812 PMID:17404015

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
multiple interactions

Carboplatin results in decreased expression of BCL2L1 protein
Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2 like 12

increases expression

Carboplatin results in increased expression of BCL2L12 mRNA

NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991

G

beclin 1

decreases expression
multiple interactions

Carboplatin results in decreased expression of BECN1 protein
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 2

decreases response to substance

BIRC2 protein results in decreased susceptibility to Carboplatin

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

bleomycin hydrolase

decreases expression

Carboplatin results in decreased expression of BLMH mRNA

NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212

G

BRCA1, DNA repair associated

decreases activity

Carboplatin results in decreased activity of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

calcium/calmodulin-dependent protein kinase kinase 2

affects response to substance

CAMKK2 protein affects the susceptibility to Carboplatin

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

calnexin

decreases expression

Carboplatin results in decreased expression of CANX mRNA

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 2

decreases expression

Carboplatin results in decreased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 protein; Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]
Carboplatin results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]
[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein; Carboplatin promotes the reaction [[Pulsatilla saponin A co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pulsatilla saponin A promotes the reaction [[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]
Carboplatin results in increased expression of CASP3 mRNA; Carboplatin results in increased expression of CASP3 protein

PMID:15576332 PMID:16275998 PMID:18483861 PMID:20368269 PMID:22302033 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Carboplatin results in increased activity of CASP7 protein
palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases activity
decreases expression
multiple interactions
increases expression

Carboplatin results in increased activity of CASP9 protein
Carboplatin results in decreased expression of CASP9 mRNA
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]

PMID:15576332 PMID:15996812 PMID:17404015 PMID:18483861

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
decreases expression
multiple interactions

Carboplatin results in decreased activity of CAT protein
Carboplatin results in decreased expression of CAT protein
Carboplatin results in decreased expression of and results in decreased activity of CAT protein

PMID:11124453 PMID:15109710 PMID:15225673

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

multiple interactions

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD274 molecule

decreases expression

Carboplatin results in decreased expression of CD274; Carboplatin results in decreased expression of CD274 protein

PMID:21765211 PMID:27692344

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

G

CD44 molecule

decreases expression

Carboplatin results in decreased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 25B

decreases expression

Carboplatin results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 42

decreases expression

Carboplatin results in decreased expression of CDC42 mRNA

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

G

cyclin-dependent kinase inhibitor 1A

increases expression

Carboplatin results in increased expression of CDKN1A protein
Carboplatin results in increased expression of CDKN1A mRNA

PMID:9664115 PMID:18172885

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

Carboplatin results in increased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

clusterin

decreases expression

Carboplatin results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

COP9 signalosome subunit 5

increases response to substance

COPS5 results in increased susceptibility to Carboplatin

NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731

G

cytochrome c, somatic

multiple interactions

Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

dopachrome tautomerase

decreases response to substance

DCT protein results in decreased susceptibility to Carboplatin

NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836

G

DNA-damage inducible transcript 3

increases expression

Carboplatin results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dihydropyrimidine dehydrogenase

multiple interactions

PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

eukaryotic translation initiation factor 2 subunit alpha

affects phosphorylation

Carboplatin affects the phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

epithelial cell adhesion molecule

multiple interactions

[Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

erythropoietin

increases expression

Carboplatin results in increased expression of EPO protein

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

Fas cell surface death receptor

increases expression

Carboplatin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

follicle stimulating hormone subunit beta

increases expression

Carboplatin results in increased expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glutathione-disulfide reductase

decreases activity

Carboplatin results in decreased activity of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

affects response to substance

GSTP1 gene affects the susceptibility to Carboplatin

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

H2A.X variant histone

increases expression
increases phosphorylation
multiple interactions

Carboplatin results in increased expression of H2AX protein
Carboplatin results in increased phosphorylation of H2AX protein
palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; phellopterin promotes the reaction [[Carboplatin results in increased phosphorylation of H2AX protein] which results in increased susceptibility to Carboplatin]; phellopterin promotes the reaction [Carboplatin results in increased phosphorylation of H2AX protein]

PMID:22302033 PMID:37708916

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

HCLS1 associated protein X-1

multiple interactions

Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein]

NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714

G

hemoglobin subunit beta

decreases expression

Carboplatin results in decreased expression of HBB mRNA

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

heme oxygenase 1

multiple interactions
increases expression
decreases response to substance
decreases expression

HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]
Carboplatin results in increased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Carboplatin
Carboplatin results in decreased expression of HMOX1 mRNA

PMID:18172885 PMID:20368269 PMID:21198546 PMID:26260164

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

Carboplatin results in decreased expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

heat shock protein family A (Hsp70) member 1A

increases expression

Carboplatin results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression

Carboplatin results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

decreases expression

Carboplatin results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

increases expression

Carboplatin results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

insulin-like growth factor 2 receptor

decreases expression

Carboplatin results in decreased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

interleukin 6

decreases response to substance

IL6 protein results in decreased susceptibility to Carboplatin

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

decreases response to substance

IL6R protein results in decreased susceptibility to Carboplatin

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

Carboplatin results in decreased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kallikrein 1-related peptidase C10

multiple interactions

[Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

mitogen-activated protein kinase kinase kinase 1

decreases expression

Carboplatin results in decreased expression of MAP3K1 mRNA

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

mitogen activated protein kinase kinase kinase 12

decreases expression

Carboplatin results in decreased expression of MAP3K12 mRNA

NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789

G

mitogen activated protein kinase 14

decreases expression

Carboplatin results in decreased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen-activated protein kinase 6

decreases expression

Carboplatin results in decreased expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

O-6-methylguanine-DNA methyltransferase

decreases expression

Carboplatin results in decreased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 155

multiple interactions

[Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

marker of proliferation Ki-67

multiple interactions

Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloperoxidase

multiple interactions

[Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 2

decreases expression

Carboplatin results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

affects response to substance

MSH6 protein affects the susceptibility to Carboplatin

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

metallothionein 1

decreases expression
increases expression

Carboplatin results in decreased expression of MT1A mRNA
Carboplatin results in increased expression of MT1A mRNA

PMID:18172885 PMID:35027733

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

MYC proto-oncogene, bHLH transcription factor

increases response to substance

MYC protein results in increased susceptibility to Carboplatin

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

Nanog homeobox

increases expression

Carboplatin results in increased expression of NANOG mRNA

NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116

G

NBAS subunit of NRZ tethering complex

affects response to substance

NBAS intron polymorphism affects the susceptibility to Carboplatin

NCBI chr 6:36,048,357...36,353,206
Ensembl chr 6:36,048,191...36,352,984

G

NCK-associated protein 1

decreases expression

Carboplatin results in decreased expression of NCKAP1 mRNA

NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217

G

nuclear factor of activated T-cells 4

multiple interactions
increases activity

HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]

NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]
Carboplatin results in decreased expression of NFKB1 mRNA

PMID:12675310 PMID:18172885

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

decreases phosphorylation
multiple interactions

Carboplatin results in decreased phosphorylation of NFKBIA protein
NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:12675310 PMID:15120608

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nodal growth differentiation factor

increases response to substance

NODAL results in increased susceptibility to Carboplatin

NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837

G

NAD(P)H quinone dehydrogenase 1

increases expression

Carboplatin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

NRAS proto-oncogene, GTPase

decreases expression

Carboplatin results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

olfactory receptor family 4 subfamily D member 6

affects response to substance

OR4D6 gene SNP affects the susceptibility to Carboplatin

NCBI chr 1:209,039,073...209,040,017
Ensembl chr 1:209,037,992...209,045,985

G

oncostatin M

increases expression

Carboplatin results in increased expression of OSM mRNA

NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313

G

poly (ADP-ribose) polymerase 1

increases cleavage

Carboplatin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

decreases expression

Carboplatin results in decreased expression of PAWR mRNA

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

proliferating cell nuclear antigen

multiple interactions
increases expression

PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]
Carboplatin results in increased expression of PCNA mRNA

PMID:16685392 PMID:18172885

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 1 ligand 2

decreases expression
multiple interactions

Carboplatin results in decreased expression of PDCD1LG2
STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]

NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938

G

protein disulfide isomerase family A, member 4

decreases expression

Carboplatin results in decreased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

protein disulfide isomerase family A, member 6

decreases expression

Carboplatin results in decreased expression of PDIA6 mRNA

NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Carboplatin results in increased expression of PMAIP1 protein

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

protein kinase D2

affects response to substance

PRKD2 protein affects the susceptibility to Carboplatin

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

proteasome 20S subunit beta 2

increases expression

Carboplatin results in increased expression of PSMB2 mRNA

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 4

decreases expression

Carboplatin results in decreased expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

prostaglandin-endoperoxide synthase 2

decreases response to substance
multiple interactions

PTGS2 protein results in decreased susceptibility to Carboplatin
wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAB10, member RAS oncogene family

decreases expression

Carboplatin results in decreased expression of RAB10 mRNA

NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193

G

RNA binding motif protein 17

decreases response to substance

RBM17 protein results in decreased susceptibility to Carboplatin

NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Carboplatin results in decreased localization of and results in decreased activity of RELA protein; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:12675310 PMID:15120608

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-Coenzyme A desaturase 2

decreases expression

Carboplatin results in decreased expression of SCD2 mRNA

NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232

G

salt-inducible kinase 1

increases response to substance

SIK1 results in increased susceptibility to Carboplatin

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 31 member 1

decreases response to substance
multiple interactions
increases import
increases uptake
increases response to substance

SLC31A1 gene mutant form results in decreased susceptibility to Carboplatin
[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin
SLC31A1 protein results in increased import of Carboplatin
SLC31A1 protein results in increased uptake of Carboplatin
SLC31A1 protein results in increased susceptibility to Carboplatin

PMID:15634647 PMID:16847145 PMID:19509135 PMID:22914438 PMID:23123662

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 31 member 2

decreases uptake

SLC31A2 protein results in decreased uptake of Carboplatin

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542

G

smoothened, frizzled class receptor

increases expression

Carboplatin results in increased expression of SMO mRNA

NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829

G

superoxide dismutase 1

multiple interactions
decreases expression

Carboplatin results in decreased expression of and results in decreased activity of SOD1 protein
Carboplatin results in decreased expression of SOD1 protein

PMID:15109710 PMID:15225673

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Carboplatin results in increased expression of and results in increased activity of SOD2 protein
Carboplatin results in decreased expression of SOD2 protein

PMID:15109710 PMID:15225673

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 2

increases expression

Carboplatin results in increased expression of SOX2 mRNA

NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338

G

signal transducer and activator of transcription 6

multiple interactions

STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

serine threonine kinase 39

decreases expression

Carboplatin results in decreased expression of STK39 mRNA

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

syntaxin 2

increases response to substance

STX2 protein results in increased susceptibility to Carboplatin

NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751

G

transcription factor AP-2 alpha

increases response to substance

TFAP2A protein results in increased susceptibility to Carboplatin

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

tumor necrosis factor

multiple interactions

[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

multiple interactions

TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide]

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

increases expression
multiple interactions

Carboplatin results in increased expression of TP53 mRNA; Carboplatin results in increased expression of TP53 protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 protein

PMID:9664115 PMID:15131059 PMID:33002289

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymidylate synthetase

multiple interactions

PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

UDP glucuronosyltransferase family 1 member A6

decreases expression

Carboplatin results in decreased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vimentin

decreases expression

Carboplatin results in decreased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xanthine dehydrogenase

affects activity

Carboplatin affects the activity of XDH protein

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

XPC complex subunit, DNA damage recognition and repair factor

decreases response to substance

XPC results in decreased susceptibility to Carboplatin

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

G

zinc finger protein 36, C3H type-like 1

decreases expression

Carboplatin results in decreased expression of ZFP36L1 mRNA

NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748

cromoglycate(2-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NME/NM23 nucleoside diphosphate kinase 2

affects binding

Chromoglycate binds to Nme2 protein

RGD

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

disodium cromoglycate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of MRP4 protein]

PMID:35114312 PMID:36464070

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

increases expression
multiple interactions

Cromolyn Sodium results in increased expression of ABCG2 protein
Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of ABCG2 protein]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

actin alpha 2, smooth muscle

multiple interactions

Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

adiponectin, C1Q and collagen domain containing

increases expression

Cromolyn Sodium results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A3 receptor

decreases activity

Cromolyn Sodium results in decreased activity of ADORA3 protein

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

angiotensinogen

multiple interactions

Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of AGT protein]

PMID:35114312 PMID:36464070

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2, apoptosis regulator

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcitonin-related polypeptide alpha

multiple interactions

Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of CALCA protein]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

cystatin C

multiple interactions

Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

catenin beta 1

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of CTNNB1 protein]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

multiple interactions

[pristane co-treated with Cromolyn Sodium] results in increased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

DNA methyltransferase 1

decreases expression

Cromolyn Sodium results in decreased expression of DNMT1 mRNA; Cromolyn Sodium results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

G protein-coupled receptor 35

affects localization
multiple interactions

Cromolyn Sodium affects the localization of GPR35 protein
2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; 2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]; Cromolyn Sodium binds to and results in increased activity of GPR35 protein; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium affects the localization of GPR35 protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Cromolyn Sodium binds to and results in increased activity of GPR35 protein]

PMID:20919992 PMID:22967846

NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299

G

glutathione peroxidase 1

multiple interactions

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

insulin 1

increases expression

Cromolyn Sodium results in increased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

mitogen activated protein kinase 1

decreases phosphorylation

Cromolyn Sodium results in decreased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of MAPK3 protein]
Cromolyn Sodium results in decreased phosphorylation of MAPK3 protein

PMID:28732690 PMID:35961540

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

decreases expression

Cromolyn Sodium results in decreased expression of METTL3 mRNA; Cromolyn Sodium results in decreased expression of METTL3 protein

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

matrix metallopeptidase 2

multiple interactions
increases expression

Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Cromolyn Sodium results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

proopiomelanocortin

multiple interactions

Cromolyn Sodium inhibits the reaction [POMC results in increased secretion of Corticosterone]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Cromolyn Sodium co-treated with Chitosan] inhibits the reaction [Dimethylhydrazines results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions

Cromolyn Sodium inhibits the reaction [Purines analog results in increased secretion of REN protein]

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

resistin

decreases expression

Cromolyn Sodium results in decreased expression of RETN protein

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

solute carrier family 22 member 12

multiple interactions

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A12 protein]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22 member 6

multiple interactions

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A6 protein]

PMID:35114312 PMID:36464070

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 8

multiple interactions

[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SLC22A8 protein]

PMID:35114312 PMID:36464070

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

superoxide dismutase 1

multiple interactions

Cromolyn Sodium inhibits the reaction [Purines analog results in decreased expression of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

tachykinin, precursor 1

multiple interactions

Cromolyn Sodium inhibits the reaction [Paclitaxel results in increased expression of TAC1 protein]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transforming growth factor, beta 1

multiple interactions
increases secretion

[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein; [masitinib co-treated with Cromolyn Sodium] results in increased secretion of TGFB1 protein
Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]
Cromolyn Sodium results in increased secretion of TGFB1 protein

PMID:35007524 PMID:35114312

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

Cromolyn Sodium inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

glutamate(2-)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamate ionotropic receptor AMPA type subunit 1

increases localization

Glutamate increases localization of Gria1 protein within medium spiny neurons

RGD

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

sodium aurothiomalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

adenosine A2a receptor

decreases expression

Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adhesion molecule with Ig like domain 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

ANTXR cell adhesion molecule 1

increases expression

Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

G

aldehyde oxidase 1

increases expression

Gold Sodium Thiomalate results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

BCL2-related protein A1

decreases expression

Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

bone marrow stromal cell antigen 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

C-C motif chemokine ligand 20

decreases expression

Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

cellular communication network factor 1

increases expression

Gold Sodium Thiomalate results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 5

increases expression

Gold Sodium Thiomalate results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

Cd28 molecule

multiple interactions
affects response to substance

CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

calmegin

decreases expression

Gold Sodium Thiomalate results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758

G

collagen type I alpha 1 chain

increases expression

Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collectin sub-family member 12

increases expression

Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

C-X-C motif chemokine ligand 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DEAD-box helicase 10

increases expression

Gold Sodium Thiomalate results in increased expression of DDX10 mRNA

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373

G

iodothyronine deiodinase 1

decreases activity

Gold Sodium Thiomalate results in decreased activity of DIO1 protein

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

EGF containing fibulin extracellular matrix protein 1

increases expression

Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 3

increases expression

Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA

NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943

G

fibrillarin

affects localization
decreases activity
multiple interactions

Gold Sodium Thiomalate affects the localization of FBL protein
Gold Sodium Thiomalate results in decreased activity of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:10942594 PMID:19077085

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

fibulin 1

increases expression

Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

fibroblast growth factor 7

increases expression

Gold Sodium Thiomalate results in increased expression of FGF7 mRNA

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

guanylate binding protein 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glycoprotein m6b

increases expression

Gold Sodium Thiomalate results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

gasdermin E

decreases expression

Gold Sodium Thiomalate results in decreased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

hypoxia inducible lipid droplet-associated

decreases expression

Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

interferon, alpha-inducible protein 27

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 35

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

multiple interactions
affects response to substance

IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

PMID:16393772 PMID:25314295

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

decreases expression

Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 23 subunit alpha

decreases expression

Gold Sodium Thiomalate results in decreased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 4

multiple interactions
affects response to substance

IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
decreases expression
affects response to substance

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:11824965 PMID:19077085 PMID:19192274

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 7

decreases expression

Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

ISG15 ubiquitin-like modifier

decreases expression

Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

laminin subunit beta 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

latexin

increases expression

Gold Sodium Thiomalate results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

lymphocyte antigen 6 family member E

decreases expression

Gold Sodium Thiomalate results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

Gold Sodium Thiomalate results in decreased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 99b

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased expression of MIR99B mRNA]

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

G

matrix metallopeptidase 10

decreases expression

Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

MX dynamin like GTPase 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

NDUFA4, mitochondrial complex associated like 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010

G

neuromedin B

decreases expression

Gold Sodium Thiomalate results in decreased expression of NMB mRNA

NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190

G

nitric oxide synthase 2

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5'-oligoadenylate synthetase-like

decreases expression

Gold Sodium Thiomalate results in decreased expression of OASL mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

olfactomedin-like 2B

increases expression

Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

phosphoglycerate dehydrogenase

decreases expression

Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phospholipid phosphatase 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

protein phosphatase 4, regulatory subunit 2

increases expression

Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

prostaglandin E synthase

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin-endoperoxide synthase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

retinoic acid receptor responder 1

increases expression

Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulator of G-protein signaling 4

decreases expression

Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

RNA sensor RIG-1

decreases expression

Gold Sodium Thiomalate results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

receptor-interacting serine-threonine kinase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

ring finger protein 19B

decreases expression

Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

radical S-adenosyl methionine domain containing 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

solute carrier family 7 member 11

decreases expression

Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

spermine synthase

decreases expression

Gold Sodium Thiomalate results in decreased expression of SMS mRNA

NCBI chr X:37,516,949...37,572,657
Ensembl chr X:37,516,931...37,570,822
Ensembl chr 3:37,516,931...37,570,822

G

superoxide dismutase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

spondin 1

increases expression

Gold Sodium Thiomalate results in increased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

signal transducer and activator of transcription 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

steroid sulfatase

increases expression

Gold Sodium Thiomalate results in increased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

thrombospondin 1

increases expression

Gold Sodium Thiomalate results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

increases expression

Gold Sodium Thiomalate results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

toll-like receptor 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

TNF alpha induced protein 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

thioredoxin interacting protein

increases expression

Gold Sodium Thiomalate results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

multiple interactions
decreases activity

Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein

PMID:16510263 PMID:17229725

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

decreases activity

Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19899
chemical entity	19897
molecular entity	19897
ion	17101
anion	16657
organic anion	6858
carboxylic acid anion	2500
dicarboxylic acid anion	253
(2R)-S-succinyl-2-(hydroxyimino)ethanethiol(2-)	0
(2S)-2-nitrosobutanedioate	0
(2S)-methylsuccinate(2-)	0
(2S,3S)-3-(phosphonomethyl)malate(3-)	0
(3R)-3-hydroxy-D-aspartate(1-)	0
(3R)-3-hydroxy-L-aspartate(1-)	0
(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate(1-)	0
(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate(1-)	0
(3S)-3-hydroxy-D-aspartate(1-)	0
(3S)-3-hydroxy-L-aspartate(1-)	0
(6R)-5,10-methenyltetrahydrofolate +	0
(E,E)-bilirubin anion	0
(R)-2-(phosphonomethyl)malate(3-)	0
(R)-S-lactoylglutathionate(1-)	0
(R)-lanthionine ketimine(2-)	0
(S)-cystathionine ketimine(2-)	0
2,2'-iminodipropanoate(1-)	0
2-(carboxylatomethyl)-5-oxo-2,5-dihydrofuran-2-ide-3-carboxylate	0
2-(phosphinatomethylidene)succinate(3-)	0
2-hydroxydicarboxylate(2-) +	0
2-hydroxyglutarate +	0
2-isopropylmalate +	0
2-nitrobutanedioate	0
2-phosphinomethylmalate(3-)	0
20-hydroxy-leukotriene E4(1-)	0
3-(1-carboxylatovinyloxy)anthranilate	0
3-hydroxysebacate +	0
3-methyladipate +	0
3-methylglutaconate anion +	0
4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde(1-)	0
4-amino-4-deoxyprephenate	0
5,12-dihydroxanthommatin(1-)	0
8-hydroxy-2-oxabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate	0
L-arogenate(1-)	0
N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-gamma-glutamyl)-D-lysine(3-)	0
N,N-dihydroxy-L-aspartate	0
N-(8'-hydroxygeranyl)-L-glutamate(1-)	0
N-(8'-oxogeranyl)-L-glutamate(1-)	0
N-carbamoylaspartate(2-)	0
N-formimidoyl-L-glutamate(1-)	0
N-geranyl-L-glutamate(1-)	0
N-hydroxy-L-aspartate	0
O-succinyl-L-homoserinate(1-)	0
O-succinyl-L-serinate(1-)	0
O13(4)-desmethyl primary fluorescent dioxobilin-type chlorophyll catabolite(2-)	0
S-[(2R)-succino]-(hydroxyimino)methanethiol(2-)	0
S-carboxylatomethyl-L-cysteine(1-)	0
UDP-N-acetylmuramoyl-L-alanyl-D-alpha-glutamyl-L-lysinate(3-)	0
UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-L-lysine(3-) +	0
actinorhodin(3-)	0
adipiodone(2-) +	0
aldaric acid anion +	0
aminomalonate(1-)	0
aspartate +	0
azelaate +	0
carboxyibuprofen anion	0
cis,cis-2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-)	0
dainate A(1-)	0
dicarboxylic acid dianion +	253
dicarboxylic acid monoanion +	0
ethylenediaminediacetate(1-)	0
ethylmalonate +	0
ferriheme a3(1-)	0
gamma-CEHC beta-glucuronide anion	0
glutarate +	0
heptadienoate +	0
hydroxymalonate +	0
icosanedioic acid anion	0
isonocardicin A(1-)	0
leukotriene E4(1-)	0
malate +	0
maleate +	0
methylsuccinate	0
octadecanedioic acid anion	0
oxalate +	20
penicilloate anion +	0
phosphinomethylisomalate(3-)	0
pimelate +	0
porphobilinogen(1-)	0
pyridinium-3,5-biscarboxylate mononucleotide(3-)	0
quinolinate +	0
sebacate +	0
suberate +	0
succinate +	0
succinyladenosine anion	0
tartrate +	0
undecanedioic acid anion	0
Path 2
Term	Annotations
CHEBI ontology	19899
subatomic particle	19897
composite particle	19897
hadron	19897
baryon	19897
nucleon	19897
atomic nucleus	19897
atom	19897
main group element atom	19835
p-block element atom	19835
carbon group element atom	19776
carbon atom	19772
organic molecular entity	19772
organic ion	11455
organic anion	6858
carboxylic acid anion	2500
dicarboxylic acid anion	253
(2R)-S-succinyl-2-(hydroxyimino)ethanethiol(2-)	0
(2S)-2-nitrosobutanedioate	0
(2S)-methylsuccinate(2-)	0
(2S,3S)-3-(phosphonomethyl)malate(3-)	0
(3R)-3-hydroxy-D-aspartate(1-)	0
(3R)-3-hydroxy-L-aspartate(1-)	0
(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate(1-)	0
(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate(1-)	0
(3S)-3-hydroxy-D-aspartate(1-)	0
(3S)-3-hydroxy-L-aspartate(1-)	0
(6R)-5,10-methenyltetrahydrofolate +	0
(E,E)-bilirubin anion	0
(R)-2-(phosphonomethyl)malate(3-)	0
(R)-S-lactoylglutathionate(1-)	0
(R)-lanthionine ketimine(2-)	0
(S)-cystathionine ketimine(2-)	0
2,2'-iminodipropanoate(1-)	0
2-(carboxylatomethyl)-5-oxo-2,5-dihydrofuran-2-ide-3-carboxylate	0
2-(phosphinatomethylidene)succinate(3-)	0
2-hydroxydicarboxylate(2-) +	0
2-hydroxyglutarate +	0
2-isopropylmalate +	0
2-nitrobutanedioate	0
2-phosphinomethylmalate(3-)	0
20-hydroxy-leukotriene E4(1-)	0
3-(1-carboxylatovinyloxy)anthranilate	0
3-hydroxysebacate +	0
3-methyladipate +	0
3-methylglutaconate anion +	0
4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde(1-)	0
4-amino-4-deoxyprephenate	0
5,12-dihydroxanthommatin(1-)	0
8-hydroxy-2-oxabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate	0
L-arogenate(1-)	0
N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-gamma-glutamyl)-D-lysine(3-)	0
N,N-dihydroxy-L-aspartate	0
N-(8'-hydroxygeranyl)-L-glutamate(1-)	0
N-(8'-oxogeranyl)-L-glutamate(1-)	0
N-carbamoylaspartate(2-)	0
N-formimidoyl-L-glutamate(1-)	0
N-geranyl-L-glutamate(1-)	0
N-hydroxy-L-aspartate	0
O-succinyl-L-homoserinate(1-)	0
O-succinyl-L-serinate(1-)	0
O13(4)-desmethyl primary fluorescent dioxobilin-type chlorophyll catabolite(2-)	0
S-[(2R)-succino]-(hydroxyimino)methanethiol(2-)	0
S-carboxylatomethyl-L-cysteine(1-)	0
UDP-N-acetylmuramoyl-L-alanyl-D-alpha-glutamyl-L-lysinate(3-)	0
UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-L-lysine(3-) +	0
actinorhodin(3-)	0
adipiodone(2-) +	0
aldaric acid anion +	0
aminomalonate(1-)	0
aspartate +	0
azelaate +	0
carboxyibuprofen anion	0
cis,cis-2-ammonio-3-(3-oxoprop-1-enyl)but-2-enedioate(1-)	0
dainate A(1-)	0
dicarboxylic acid dianion +	253
dicarboxylic acid monoanion +	0
ethylenediaminediacetate(1-)	0
ethylmalonate +	0
ferriheme a3(1-)	0
gamma-CEHC beta-glucuronide anion	0
glutarate +	0
heptadienoate +	0
hydroxymalonate +	0
icosanedioic acid anion	0
isonocardicin A(1-)	0
leukotriene E4(1-)	0
malate +	0
maleate +	0
methylsuccinate	0
octadecanedioic acid anion	0
oxalate +	20
penicilloate anion +	0
phosphinomethylisomalate(3-)	0
pimelate +	0
porphobilinogen(1-)	0
pyridinium-3,5-biscarboxylate mononucleotide(3-)	0
quinolinate +	0
sebacate +	0
suberate +	0
succinate +	0
succinyladenosine anion	0
tartrate +	0
undecanedioic acid anion	0

paths to the root