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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:adrenergic uptake inhibitor
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Accession:CHEBI:35640 term browser browse the term
Definition:Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Synonyms:related_synonym: ARI;   NERI;   NRI;   adrenergic reuptake inhibitor;   adrenergic reuptake inhibitors;   adrenergic uptake inhibitors;   norepinephrine reuptake inhibitor;   norepinephrine reuptake inhibitors


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Your selection has 4824 annotated objects. The maximum number of objects that can be shown is 2000. The list is too large to display.

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    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19898
        role 19868
          biological role 19866
            pharmacological role 19098
              neurotransmitter agent 16808
                adrenergic agent 9185
                  adrenergic uptake inhibitor 4824
                    (R,R)-tramadol + 38
                    (R,R)-tramadol hydrochloride + 0
                    (S)-amphetamine + 3607
                    (S,S)-tramadol + 38
                    (S,S)-tramadol hydrochloride + 0
                    amezinium + 0
                    amezinium metilsulfate 0
                    amitriptyline + 189
                    amoxapine 8
                    amphetamine + 2222
                    atomoxetine + 1
                    atomoxetine hydrochloride 1
                    benzphetamine + 2
                    benzphetamine hydrochloride 0
                    cocaine 1449
                    desipramine + 51
                    imipramine + 136
                    methylphenidate 147
                    mianserin + 17
                    nefopam 1
                    nefopam hydrochloride 0
                    nisoxetine 2
                    nortriptyline 21
                    reserpine 120
                    tetrabenazine 2
                    tramadol 38
                    tramadol hydrochloride 0
                    venlafaxine + 182
    Path 2
    Term Annotations click to browse term
      CHEBI ontology 19898
        role 19868
          application 19714
            pharmaceutical 19550
              drug 19550
                neurotransmitter agent 16808
                  adrenergic agent 9185
                    adrenergic uptake inhibitor 4824
                      (R,R)-tramadol + 38
                      (R,R)-tramadol hydrochloride + 0
                      (S)-amphetamine + 3607
                      (S,S)-tramadol + 38
                      (S,S)-tramadol hydrochloride + 0
                      amezinium + 0
                      amezinium metilsulfate 0
                      amitriptyline + 189
                      amoxapine 8
                      amphetamine + 2222
                      atomoxetine + 1
                      atomoxetine hydrochloride 1
                      benzphetamine + 2
                      benzphetamine hydrochloride 0
                      cocaine 1449
                      desipramine + 51
                      imipramine + 136
                      methylphenidate 147
                      mianserin + 17
                      nefopam 1
                      nefopam hydrochloride 0
                      nisoxetine 2
                      nortriptyline 21
                      reserpine 120
                      tetrabenazine 2
                      tramadol 38
                      tramadol hydrochloride 0
                      venlafaxine + 182
    paths to the root