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G |
Bglap |
bone gamma-carboxyglutamate protein |
decreases expression |
ISO |
Calcium Carbonate results in decreased expression of BGLAP protein |
CTD |
PMID:2027271 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Capn1 |
calpain 1 |
increases activity |
ISO |
Calcium Carbonate analog results in increased activity of CAPN1 protein |
CTD |
PMID:24412303 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
Calcium Carbonate analog results in increased activity of CASP3 protein |
CTD |
PMID:24412303 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Calcium Carbonate analog results in increased expression of DDIT3 |
CTD |
PMID:24412303 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Pth |
parathyroid hormone |
affects expression decreases expression |
ISO |
Calcium Carbonate affects the expression of PTH protein Calcium Carbonate results in decreased expression of PTH protein |
CTD |
PMID:1752077 PMID:2027271 PMID:3826069 PMID:7891547 PMID:8481062 PMID:16006300 More...
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NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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G |
Pthlh |
parathyroid hormone-like hormone |
decreases expression |
ISO |
Calcium Carbonate results in decreased expression of PTHLH protein |
CTD |
PMID:16006300 |
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NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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G |
Spp1 |
secreted phosphoprotein 1 |
decreases expression |
ISO |
Calcium Carbonate results in decreased expression of SPP1 protein |
CTD |
PMID:17977878 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Adcy10 |
adenylate cyclase 10 |
increases expression |
ISO |
Bicarbonates results in increased expression of ADCY10 protein |
CTD |
PMID:15117409 |
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NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein affects the reaction [[Iron co-treated with Bicarbonates] results in increased abundance of Malondialdehyde] |
CTD |
PMID:16027354 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Car1 |
carbonic anhydrase 1 |
increases chemical synthesis |
ISO |
CA1 protein results in increased chemical synthesis of Bicarbonates |
CTD |
PMID:17826101 |
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NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car2 |
carbonic anhydrase 2 |
increases chemical synthesis |
ISO |
CA2 protein results in increased chemical synthesis of Bicarbonates |
CTD |
PMID:17826101 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Car3 |
carbonic anhydrase 3 |
increases chemical synthesis |
ISO |
CA3 protein results in increased chemical synthesis of Bicarbonates |
CTD |
PMID:17826101 |
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NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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G |
Cftr |
CF transmembrane conductance regulator |
increases transport decreases transport decreases secretion multiple interactions affects transport decreases activity |
ISO |
CFTR protein results in increased transport of Bicarbonates CFTR protein mutant form results in decreased transport of Bicarbonates CFTR protein mutant form results in decreased secretion of Bicarbonates Glyburide inhibits the reaction [CFTR protein affects the transport of Bicarbonates] [Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; Cyclic AMP promotes the reaction [CFTR protein results in increased transport of Bicarbonates] Bicarbonates results in decreased activity of CFTR protein |
CTD |
PMID:11786964 PMID:14679199 PMID:15286085 PMID:15480994 PMID:15650130 PMID:32374624 More...
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Edn3 |
endothelin 3 |
affects secretion |
EXP |
Bicarbonates affects the secretion of EDN3 protein |
CTD |
PMID:15949640 |
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NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in increased secretion of Bicarbonates |
CTD |
PMID:18499763 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
[2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] which results in increased secretion of Bicarbonates |
CTD |
PMID:18499763 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Slc26a3 |
solute carrier family 26 member 3 |
affects transport |
ISO |
SLC26A3 protein affects the transport of Bicarbonates |
CTD |
PMID:12651923 |
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NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
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G |
Slc26a6 |
solute carrier family 26 member 6 |
multiple interactions increases transport |
ISO |
Estradiol inhibits the reaction [SLC26A6 protein results in increased transport of Bicarbonates] |
CTD |
PMID:35500753 |
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NCBI chr 8:109,558,968...109,569,778
Ensembl chr 8:109,559,642...109,569,778
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G |
Slc39a8 |
solute carrier family 39 member 8 |
multiple interactions |
ISO |
Bicarbonates affects the reaction [SLC39A8 protein results in increased uptake of Zinc]; Bicarbonates promotes the reaction [SLC39A8 protein results in increased uptake of Cadmium]; SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates] |
CTD |
PMID:16638970 PMID:27956349 |
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NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
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G |
Slc4a2 |
solute carrier family 4 member 2 |
multiple interactions |
ISO EXP |
Bicarbonates inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid] Nitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]; SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates] SLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates] |
CTD |
PMID:9563070 PMID:11852051 PMID:12612912 |
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NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965
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G |
Slc9a2 |
solute carrier family 9 member A2 |
affects transport |
EXP |
SLC9A2 protein affects the transport of Bicarbonates |
CTD |
PMID:11704563 |
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NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444
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G |
Slc9a3 |
solute carrier family 9 member A3 |
affects uptake multiple interactions affects transport |
EXP |
SLC9A3 protein affects the uptake of Bicarbonates [3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates; [5-dimethylamiloride results in decreased activity of SLC9A3 protein] which results in increased secretion of Bicarbonates SLC9A3 protein affects the transport of Bicarbonates |
CTD |
PMID:11704563 PMID:12427137 PMID:12881227 |
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NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
[[[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid] which results in increased chemical synthesis of Carbonates; [[Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]] which results in increased reduction of peroxycarbonic acid; [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide]] which results in increased chemical synthesis of Carbonates; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein binds to peroxycarbonic acid]; [Bicarbonates co-treated with Carbon Dioxide] promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide]; [Peroxynitrous Acid co-treated with Bicarbonates] results in decreased activity of SOD1 protein; [Peroxynitrous Acid co-treated with Bicarbonates] results in increased metabolism of SOD1 protein; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] results in increased oxidation of [Bicarbonates co-treated with Carbon Dioxide] |
CTD |
PMID:11451436 PMID:19243126 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions decreases activity |
EXP |
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of ALAD protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of ALAD protein]; Zinc Sulfate inhibits the reaction [Lithium Carbonate results in decreased activity of ALAD protein] |
CTD |
PMID:19083387 PMID:28988373 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Casp1 |
caspase 1 |
increases expression |
ISO |
Lithium Carbonate results in increased expression of CASP1 protein |
CTD |
PMID:34984798 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases expression |
EXP ISO |
Lithium Carbonate results in increased activity of CASP3 protein Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein] Lithium Carbonate results in increased expression of CASP3 protein |
CTD |
PMID:27588890 PMID:34984798 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
increases expression |
ISO |
Lithium Carbonate results in increased expression of CASP6 protein |
CTD |
PMID:34984798 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
increases expression |
ISO |
Lithium Carbonate results in increased expression of CASP7 protein |
CTD |
PMID:34984798 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Lithium Carbonate results in increased expression of CASP9 protein |
CTD |
PMID:34984798 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases activity multiple interactions |
EXP ISO |
Lithium Carbonate results in decreased activity of CAT protein Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of CAT protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of CAT protein] |
CTD |
PMID:28988373 PMID:34984798 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases activity |
EXP |
Lithium Carbonate promotes the reaction [sodium arsenite results in decreased activity of GSR protein]; sodium arsenite promotes the reaction [Lithium Carbonate results in decreased activity of GSR protein] |
CTD |
PMID:28988373 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA |
CTD |
PMID:29594315 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
decreases expression increases expression |
ISO |
Lithium Carbonate results in decreased expression of IL1B mRNA Lithium Carbonate results in increased expression of IL1B mRNA; Lithium Carbonate results in increased expression of IL1B protein |
CTD |
PMID:29594315 PMID:34984798 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Lithium Carbonate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA |
CTD |
PMID:29594315 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Ins1 |
insulin 1 |
decreases expression multiple interactions |
EXP |
Lithium Carbonate results in decreased expression of INS1 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] |
CTD |
PMID:10700396 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation |
ISO |
Lithium Carbonate results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:34984798 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Lithium Carbonate results in increased expression of NLRP3 protein |
CTD |
PMID:34984798 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Pfkfb2 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
decreases activity multiple interactions |
EXP |
Lithium Carbonate results in decreased activity of PFKFB2 protein Lithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein] |
CTD |
PMID:10700396 |
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NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
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G |
Pla2g4a |
phospholipase A2 group 4A |
increases expression |
ISO |
Lithium Carbonate results in increased expression of PLA2G4A mRNA; Lithium Carbonate results in increased expression of PLA2G4A protein |
CTD |
PMID:17594078 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Pth |
parathyroid hormone |
increases expression |
ISO |
Lithium Carbonate results in increased expression of PTH protein |
CTD |
PMID:3083797 PMID:18234408 |
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NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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G |
Pycard |
PYD and CARD domain containing |
increases expression |
ISO |
Lithium Carbonate results in increased expression of PYCARD protein |
CTD |
PMID:34984798 |
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NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases phosphorylation |
ISO |
Lithium Carbonate results in increased phosphorylation of RELA protein |
CTD |
PMID:34984798 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
Lithium Carbonate results in increased expression of TNF mRNA; Lithium Carbonate results in increased expression of TNF protein |
CTD |
PMID:34984798 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
EXP |
Sodium Bicarbonate results in increased expression of ABCC2 mRNA |
CTD |
PMID:29126803 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases expression |
EXP |
Sodium Bicarbonate results in decreased expression of ABCG2 mRNA |
CTD |
PMID:29126803 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Car2 |
carbonic anhydrase 2 |
decreases expression |
EXP |
Sodium Bicarbonate results in decreased expression of CAR2 mRNA |
CTD |
PMID:31569818 |
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NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Cat |
catalase |
multiple interactions |
ISO |
[Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein |
CTD |
PMID:25559736 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] |
CTD |
PMID:10430982 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Sodium Bicarbonate affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
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NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
multiple interactions |
ISO |
[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] |
CTD |
PMID:25559736 |
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NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] |
CTD |
PMID:25559736 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc15a1 |
solute carrier family 15 member 1 |
decreases expression |
EXP |
Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA |
CTD |
PMID:29126803 |
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NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
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G |
Slc22a19 |
solute carrier family 22, member 19 |
increases expression |
EXP |
Sodium Bicarbonate results in increased expression of SLC22A24 mRNA |
CTD |
PMID:29126803 |
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NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases expression |
EXP |
Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA |
CTD |
PMID:29126803 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc39a8 |
solute carrier family 39 member 8 |
multiple interactions |
EXP |
SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] |
CTD |
PMID:21509381 |
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NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
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G |
Slc4a1 |
solute carrier family 4 member 1 (Diego blood group) |
decreases expression |
EXP |
Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA |
CTD |
PMID:31569818 |
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NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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G |
Slc4a4 |
solute carrier family 4 member 4 |
increases transport decreases expression |
ISO EXP |
SLC4A4 protein results in increased transport of Sodium Bicarbonate Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA |
CTD |
PMID:18614622 PMID:31569818 |
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NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] |
CTD |
PMID:10430982 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] |
CTD |
PMID:25559736 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] |
CTD |
PMID:25559736 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vim |
vimentin |
multiple interactions |
EXP |
Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] |
CTD |
PMID:10430982 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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