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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perhexiline
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Accession:CHEBI:35553 term browser browse the term
Definition:A piperidine that has formula C19H35N.
Synonyms:exact_synonym: 2-(2,2-dicyclohexylethyl)piperidine
 related_synonym: Formula=C19H35N;   InChI=1S/C19H35N/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18/h16-20H,1-15H2;   InChIKey=CYXKNKQEMFBLER-UHFFFAOYSA-N;   Perhexilene;   SMILES=C1CCC(CC1)C(CC1CCCCN1)C1CCCCC1
 xref: Beilstein:4979856;   CAS:6621-47-2;   DrugBank:DB01074;   Drug_Central:2106;   LINCS:LSM-4353
 xref_mesh: MESH:D010480
 xref: Wikipedia:Perhexiline


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perhexiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Perhexiline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity		 EXP
ISO		 Perhexiline results in decreased expression of ABCB4 mRNA
Perhexiline results in decreased activity of ABCB4 protein		 CTD PMID:27765674 PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Perhexiline results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Perhexiline results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Perhexiline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Perhexiline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Perhexiline results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Perhexiline results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA] CTD PMID:36083301 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA] CTD PMID:36083301 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP1A2 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline]; Perhexiline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 PMID:36083301 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO CYP2C19 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP2C19 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance
multiple interactions		 ISO CYP2D6 protein results in decreased susceptibility to Perhexiline
CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF6 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA]; CYP2D6 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]		 CTD PMID:28762043 PMID:36083301 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline]; CYP3A4 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA; [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 mRNA]; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of DDIT3 protein] CTD PMID:36083301 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Perhexiline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of EIF2AK3 mRNA] CTD PMID:36083301 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Perhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:19771169 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA; CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ERN1 mRNA] CTD PMID:36083301 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Perhexiline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Perhexiline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Perhexiline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Hpn hepsin increases expression ISO Perhexiline results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Perhexiline results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Perhexiline binds to KCNH2 protein CTD PMID:18701618 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lss lanosterol synthase increases expression ISO Perhexiline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Perhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:19771169 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Perhexiline results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Perhexiline results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Perhexiline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Perhexiline results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Perhexiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression
decreases expression		 ISO Perhexiline results in increased expression of SLC2A3 mRNA
Perhexiline results in decreased expression of SLC2A3 mRNA		 CTD PMID:15342952 PMID:17175557 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Tagln transgelin decreases expression ISO Perhexiline results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Perhexiline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
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  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
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              perhexiline 36
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  CHEBI ontology 19880
    subatomic particle 19878
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                  main group element atom 19817
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                              organic cyclic compound 19495
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                                  organic heteromonocyclic compound 17795
                                    piperidines 7769
                                      perhexiline 36
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