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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lipooligosaccharide
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Accession:CHEBI:35371 term browser browse the term
Synonyms:related_synonym: LOS;   lipooligosaccharides
 alt_id: CHEBI:25053;   CHEBI:25060
 xref: KEGG:C19596


show annotations for term's descendants           Sort by:
eritoran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7b ATPase copper transporting beta multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] CTD PMID:38761876 NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein] CTD PMID:38761876 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein] CTD PMID:38761876 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein] CTD PMID:38761876 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein] CTD PMID:38761876 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein] CTD PMID:38761876 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO eritoran inhibits the reaction [Azathioprine results in increased expression of GPT protein]; eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein] CTD PMID:24184165 PMID:24747151 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein] CTD PMID:38761876 NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein] CTD PMID:38761876 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein] CTD PMID:38761876 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein] CTD PMID:38761876 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein] CTD PMID:38761876 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] CTD PMID:38761876 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein] CTD PMID:38761876 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein] CTD PMID:38761876 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein] CTD PMID:38761876 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] CTD PMID:38761876 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] CTD PMID:38761876 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
lipid As term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Lipid A results in increased expression of CCL3 mRNA
anacetrapib inhibits the reaction [Lipid A results in increased expression of CCL3 mRNA]		 CTD PMID:20448206 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG protein
Lipid A results in increased expression of IFNG mRNA; Lipid A results in increased expression of IFNG protein		 CTD PMID:16299289 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12A mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein]
Lipid A results in increased expression of IL12A mRNA		 CTD PMID:16299289 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12B mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12B mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein]
Lipid A results in increased expression of IL12B mRNA		 CTD PMID:16299289 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il15 interleukin 15 multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL15 mRNA
Lipid A results in increased expression of IL15 mRNA		 CTD PMID:16299289 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 increases expression ISO Lipid A results in increased expression of IL18 mRNA CTD PMID:16299289 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO anacetrapib inhibits the reaction [Lipid A results in increased expression of IL6 mRNA] CTD PMID:20448206 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO anacetrapib inhibits the reaction [Lipid A results in increased expression of TNF mRNA] CTD PMID:20448206 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    chemical entity 19907
      atom 19907
        nonmetal atom 19831
          oxygen atom 19572
            oxygen molecular entity 19572
              organooxygen compound 19216
                carbohydrates and carbohydrate derivatives 15321
                  glycan 8423
                    oligosaccharide derivative 160
                      lipooligosaccharide 24
                        4-(18,20-dihydroxy-26-methoxy-25-methyloctacosyl)phenyl 3,6-di-O-methyl-beta-D-Glc-(1->4)-2,3-di-O-methyl-alpha-L-Rha-(1->2)-3-O-methyl-alpha-L-Rha 0
                        LOSGM1 0
                        N. meningiditis L7 lipoundecasaccharide 0
                        lipid As + 24
                        phenolic glycolipid K-I 0
                        phenolic glycolipid-1 0
                        phenolic glycolipid-TB1 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbohydrates and carbohydrate derivatives 15321
                                    carbohydrate 15321
                                      oligosaccharide 633
                                        oligosaccharide derivative 160
                                          lipooligosaccharide 24
                                            4-(18,20-dihydroxy-26-methoxy-25-methyloctacosyl)phenyl 3,6-di-O-methyl-beta-D-Glc-(1->4)-2,3-di-O-methyl-alpha-L-Rha-(1->2)-3-O-methyl-alpha-L-Rha 0
                                            LOSGM1 0
                                            N. meningiditis L7 lipoundecasaccharide 0
                                            lipid As + 24
                                            phenolic glycolipid K-I 0
                                            phenolic glycolipid-1 0
                                            phenolic glycolipid-TB1 0
paths to the root