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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iminium ion
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Accession:CHEBI:35286 term browser browse the term
Definition:Cations of structure R2C=N(+)R2.
Synonyms:related_synonym: iminium cations;   iminium ions


show annotations for term's descendants           Sort by:
auramine O term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression		 ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]
Benzophenoneidum results in increased expression of ALDH1A1 protein		 CTD PMID:28722353 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Ano6 anoctamin 6 increases expression ISO Benzophenoneidum results in increased expression of ANO6 protein CTD PMID:28722353 NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Benzophenoneidum results in increased expression of ARAF protein CTD PMID:28722353 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 increases expression ISO Benzophenoneidum results in increased expression of ATP6AP2 protein CTD PMID:28722353 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 increases expression ISO Benzophenoneidum results in increased expression of CCDC22 protein CTD PMID:28722353 NCBI chr  X:14,898,296...14,910,244
Ensembl chr  X:14,898,296...14,910,244 		JBrowse link
G Ccdc39 coiled-coil domain 39 molecular ruler complex subunit increases expression ISO Benzophenoneidum results in increased expression of CCDC39 protein CTD PMID:28722353 NCBI chr 2:116,665,651...116,703,354
Ensembl chr 2:116,665,261...116,703,350 		JBrowse link
G Cd44 CD44 molecule increases expression ISO Benzophenoneidum results in increased expression of CD44 protein CTD PMID:28722353 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 increases expression ISO Benzophenoneidum results in increased expression of CHTF18 protein CTD PMID:28722353 NCBI chr10:14,743,006...14,751,044
Ensembl chr10:14,742,621...14,751,050 		JBrowse link
G Commd1 copper metabolism domain containing 1 increases expression ISO Benzophenoneidum results in increased expression of COMMD1 protein CTD PMID:28722353 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Cops7b COP9 signalosome subunit 7B increases expression ISO Benzophenoneidum results in increased expression of COPS7B protein CTD PMID:28722353 NCBI chr 9:87,238,132...87,263,967
Ensembl chr 9:87,238,375...87,263,967 		JBrowse link
G Cul3 cullin 3 increases expression ISO Benzophenoneidum results in increased expression of CUL3 protein CTD PMID:28722353 NCBI chr 9:81,592,641...81,670,428
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 increases expression ISO Benzophenoneidum results in increased expression of DYNLT1 protein CTD PMID:28722353 NCBI chr 1:46,887,017...46,893,956
Ensembl chr 1:46,887,017...46,893,881 		JBrowse link
G Eif4g3 eukaryotic translation initiation factor 4 gamma, 3 increases expression ISO Benzophenoneidum results in increased expression of EIF4G3 protein CTD PMID:28722353 NCBI chr 5:150,197,410...150,418,862
Ensembl chr 5:150,195,226...150,418,363 		JBrowse link
G Fastkd2 FAST kinase domains 2 increases expression ISO Benzophenoneidum results in increased expression of FASTKD2 protein CTD PMID:28722353 NCBI chr 9:65,166,148...65,188,184
Ensembl chr 9:65,168,228...65,188,174 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation EXP Benzophenoneidum results in increased phosphorylation of H2AX protein CTD PMID:37527026 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hook3 hook microtubule-tethering protein 3 increases expression ISO Benzophenoneidum results in increased expression of HOOK3 protein CTD PMID:28722353 NCBI chr16:65,954,293...66,058,812
Ensembl chr16:65,954,350...66,061,338 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO Benzophenoneidum results in increased expression of HSD17B7 protein CTD PMID:28722353 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Htt huntingtin increases expression ISO Benzophenoneidum results in increased expression of HTT protein CTD PMID:28722353 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Iqgap3 IQ motif containing GTPase activating protein 3 increases expression ISO Benzophenoneidum results in increased expression of IQGAP3 protein CTD PMID:28722353 NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956 		JBrowse link
G Kifap3 kinesin-associated protein 3 increases expression ISO Benzophenoneidum results in increased expression of KIFAP3 protein CTD PMID:28722353 NCBI chr13:76,127,702...76,264,654
Ensembl chr13:76,127,696...76,264,650 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO ALDH1A1 protein promotes the reaction [Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein]; Benzophenoneidum results in increased lipidation of and results in increased cleavage of MAP1LC3B protein CTD PMID:28722353 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 increases expression ISO Benzophenoneidum results in increased expression of MAP2K4 protein CTD PMID:28722353 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 increases expression ISO Benzophenoneidum results in increased expression of MBD3 protein CTD PMID:28722353 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Benzophenoneidum results in increased expression of MKI67 protein CTD PMID:37527026 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Noa1 nitric oxide associated 1 increases expression ISO Benzophenoneidum results in increased expression of NOA1 protein CTD PMID:28722353 NCBI chr14:30,835,264...30,851,294
Ensembl chr14:30,835,247...30,851,293 		JBrowse link
G Nup62 nucleoporin 62 increases expression ISO Benzophenoneidum results in increased expression of NUP62 protein CTD PMID:28722353 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases expression ISO Benzophenoneidum results in increased expression of PLCG1 protein CTD PMID:28722353 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ppp4r1 protein phosphatase 4, regulatory subunit 1 increases expression ISO Benzophenoneidum results in increased expression of PPP4R1 protein CTD PMID:28722353 NCBI chr 9:105,391,271...105,450,626
Ensembl chr 9:105,391,412...105,450,633 		JBrowse link
G Prim2 DNA primase subunit 2 increases expression ISO Benzophenoneidum results in increased expression of PRIM2 protein CTD PMID:28722353 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030 		JBrowse link
G Prom1 prominin 1 increases expression ISO Benzophenoneidum results in increased expression of PROM1 protein CTD PMID:28722353 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression ISO Benzophenoneidum results in increased expression of PRORP protein CTD PMID:28722353 NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 increases expression ISO Benzophenoneidum results in increased expression of SHMT1 protein CTD PMID:28722353 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Srsf11 serine and arginine rich splicing factor 11 increases expression ISO Benzophenoneidum results in increased expression of SRSF11 protein CTD PMID:28722353 NCBI chr 2:247,074,623...247,101,460
Ensembl chr 2:247,074,631...247,101,425 		JBrowse link
G Tbc1d15 TBC1 domain family, member 15 increases expression ISO Benzophenoneidum results in increased expression of TBC1D15 protein CTD PMID:28722353 NCBI chr 7:50,804,553...50,860,272
Ensembl chr 7:50,804,012...50,860,175 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Benzophenoneidum results in increased expression of TFAM protein CTD PMID:28722353 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Usp24 ubiquitin specific peptidase 24 increases expression ISO Benzophenoneidum results in increased expression of USP24 protein CTD PMID:28722353 NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311 		JBrowse link
G Washc5 WASH complex subunit 5 increases expression ISO Benzophenoneidum results in increased expression of WASHC5 protein CTD PMID:28722353 NCBI chr 7:90,884,192...90,936,096
Ensembl chr 7:90,884,197...90,936,103 		JBrowse link
brilliant green term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:26177467 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO brilliant green results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26177467 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brilliant green results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO brilliant green results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO brilliant green results in increased expression of LONP1 mRNA CTD PMID:21215310 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO brilliant green inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO brilliant green results in increased oxidation of TXN protein CTD PMID:21215310 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txn2 thioredoxin 2 decreases expression
multiple interactions
affects response to substance		 ISO brilliant green results in decreased expression of TXN2 protein
brilliant green results in increased oxidation of and results in increased degradation of TXN2 protein
TXN2 protein affects the susceptibility to brilliant green		 CTD PMID:21215310 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
crystal violet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]] CTD PMID:24535435 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein binds to BBC3 promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]] CTD PMID:24535435 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Gentian Violet results in decreased expression of BCL2 protein CTD PMID:27373978 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Gentian Violet results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:26177467 PMID:27373978 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Gentian Violet results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:26177467 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Gentian Violet results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Gentian Violet promotes the reaction [TP53 protein binds to CDKN1A promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA] CTD PMID:24535435 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Gentian Violet inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO Gentian Violet results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Gentian Violet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO Gentian Violet inhibits the reaction [NOX1 protein results in decreased activity of TP53 protein] CTD PMID:24535435 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Gentian Violet results in increased cleavage of PARP1 protein CTD PMID:24535435 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Gentian Violet promotes the reaction [Thiostrepton affects the expression of PRDX3 protein modified form] CTD PMID:22761781 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Gentian Violet inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sox2 SRY-box transcription factor 2 multiple interactions ISO [Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein] inhibits the reaction [STAT3 protein binds to SOX2 promoter] CTD PMID:27373978 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein] inhibits the reaction [STAT3 protein binds to SOX2 promoter]; Gentian Violet results in decreased phosphorylation of and affects the localization of STAT3 protein CTD PMID:27373978 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects activity		 ISO Gentian Violet inhibits the reaction [NOX1 protein results in decreased activity of TP53 protein]; Gentian Violet promotes the reaction [TP53 protein binds to BBC3 promoter]; Gentian Violet promotes the reaction [TP53 protein binds to CDKN1A promoter]; Gentian Violet promotes the reaction [TP53 protein binds to TP53AIP1 promoter]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]; Gentian Violet promotes the reaction [TP53 protein results in increased expression of CDKN1A mRNA]; Gentian Violet results in increased stability of and results in increased activity of TP53 protein; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BAX mRNA]]; pifithrin inhibits the reaction [Gentian Violet promotes the reaction [TP53 protein results in increased expression of BBC3 mRNA]]
Gentian Violet affects the activity of TP53 protein		 CTD PMID:24535435 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn2 thioredoxin 2 decreases expression ISO Gentian Violet results in decreased expression of TXN2 protein CTD PMID:22761781 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
diminazene diaceturate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 increases expression
multiple interactions
increases activity		 ISO
EXP		 diminazene aceturate results in increased expression of ACE2 mRNA; diminazene aceturate results in increased expression of ACE2 protein
[Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 mRNA; [Lipopolysaccharides co-treated with diminazene aceturate] results in increased expression of ACE2 protein; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]
diminazene aceturate results in increased activity of ACE2 protein
PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein]		 CTD PMID:25301841 PMID:26862037 PMID:27550926 PMID:28688122 PMID:31982938 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression ISO diminazene aceturate results in decreased expression of ACTA2 protein CTD PMID:29977014 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen increases expression
multiple interactions		 ISO diminazene aceturate results in increased expression of AGT protein modified form
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]]; ACE2 protein affects the reaction [diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGT protein]; diminazene aceturate promotes the reaction [Lipopolysaccharides results in increased expression of AGT protein alternative form]
diminazene aceturate results in increased expression of AGT protein alternative form		 CTD PMID:25301841 PMID:26862037 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR1 mRNA] CTD PMID:26862037 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G App amyloid beta precursor protein affects expression ISO diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aurka aurora kinase A decreases expression ISO diminazene aceturate results in decreased expression of AURKA mRNA CTD PMID:37681557 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Casp3 caspase 3 increases activity ISO diminazene aceturate results in increased activity of CASP3 protein CTD PMID:37681557 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions		 ISO diminazene aceturate results in decreased expression of MCP1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]		 CTD PMID:26862037 PMID:29977014 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO diminazene aceturate results in decreased expression of CCNA2 mRNA CTD PMID:37681557 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO diminazene aceturate results in decreased expression of CDC25A mRNA CTD PMID:37681557 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO diminazene aceturate results in decreased expression of COL1A1 protein CTD PMID:29977014 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression ISO diminazene aceturate results in decreased expression of CYBB protein CTD PMID:29977014 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO diminazene aceturate results in decreased expression of FOXM1 mRNA CTD PMID:37681557 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO diminazene aceturate results in decreased expression of FURIN mRNA CTD PMID:37681557 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases phosphorylation ISO diminazene aceturate results in increased phosphorylation of GRIN2B protein CTD PMID:31982938 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP
ISO		 diminazene aceturate results in decreased expression of IL1B mRNA
diminazene aceturate results in decreased expression of IL1B protein		 CTD PMID:25883526 PMID:31982938 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO
EXP		 diminazene aceturate results in decreased expression of IL6 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:25883526 PMID:26862037 PMID:29977014 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO diminazene aceturate results in increased phosphorylation of MAPK1 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation EXP diminazene aceturate results in decreased phosphorylation of MAPK14 protein CTD PMID:25883526 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO diminazene aceturate results in increased phosphorylation of MAPK3 protein
7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26862037 PMID:31982938 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression ISO diminazene aceturate results in increased expression of MAS1 protein CTD PMID:31982938 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO diminazene aceturate results in decreased expression of MCM3 mRNA CTD PMID:37681557 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO diminazene aceturate results in decreased expression of MKI67 mRNA CTD PMID:37681557 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO diminazene aceturate results in decreased expression of MYC mRNA CTD PMID:37681557 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression ISO diminazene aceturate results in decreased expression of NCF1 protein CTD PMID:29977014 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases transport ISO diminazene aceturate results in decreased transport of NCF2 protein CTD PMID:29977014 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 7-Ala-angiotensin (1-7) inhibits the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ACE2 protein affects the reaction [diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; diminazene aceturate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:26862037 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP diminazene aceturate results in decreased expression of NOS1 mRNA CTD PMID:25883526 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nox1 NADPH oxidase 1 decreases expression ISO diminazene aceturate results in decreased expression of NOX1 protein CTD PMID:29977014 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO diminazene aceturate results in decreased expression of PCNA mRNA CTD PMID:37681557 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO diminazene aceturate results in decreased expression of PLK1 mRNA CTD PMID:37681557 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk4 polo-like kinase 4 decreases expression ISO diminazene aceturate results in decreased expression of PLK4 mRNA CTD PMID:37681557 NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity
decreases expression		 EXP diminazene aceturate results in decreased activity of RELA protein
diminazene aceturate results in decreased expression of RELA mRNA; diminazene aceturate results in decreased expression of RELA protein		 CTD PMID:25883526 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD2 protein CTD PMID:29977014 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion		 EXP
ISO		 diminazene aceturate results in decreased expression of TNF mRNA; diminazene aceturate results in decreased expression of TNF protein
diminazene aceturate results in decreased secretion of TNF protein		 CTD PMID:25883526 PMID:29977014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
malachite green cation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO malachite green results in decreased activity of BCHE protein CTD PMID:16036213 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein CTD PMID:12616621 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCND1 protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:10906429 PMID:12616621 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP malachite green promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein] CTD PMID:10906429 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein CTD PMID:12616621 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK4 protein CTD PMID:12616621 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNA3 protein
[malachite green results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO malachite green results in decreased activity of KCNH2 protein
[malachite green results in decreased activity of KCNH2 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Khnyn KH and NYN domain containing affects response to substance ISO KHNYN gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with malachite green] results in increased expression of PCNA protein; malachite green promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein] CTD PMID:10906429 PMID:11831363 PMID:12616621 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Rnf150 ring finger protein 150 affects response to substance ISO RNF150 gene SNP affects the susceptibility to malachite green CTD PMID:25622337 NCBI chr19:25,006,978...25,229,273
Ensembl chr19:25,006,611...25,228,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19896
        ion 17094
          organic ion 11451
            organic cation 8962
              iminium ion 98
                1-piperideinium 0
                11-beta-hydroxy-beta-saxitoxinol(2+) 0
                11-beta-hydroxysaxitoxin(2+) 0
                2-amino-6-(aminomethyl)-5-methylidene-4-oxo-1,4,5,6,7,8-hexahydropteridin-5-ium 0
                2-methyl-1-pyrrolinium 0
                4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                Fast green FCF(1+) 0
                Guinee green B(1+) 0
                Methyl violet 2B(1+) + 0
                N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium 0
                QSY21 succinimidyl ester(1+) + 0
                QSY7 succinimidyl ester(1+) + 0
                QSY9 succinimidyl ester(1+) + 0
                ToTo-3(4+) + 0
                X-rhod-1(1+) + 0
                YoYo-3(4+) + 0
                acid green 5(1+) 0
                acridine red 3B(1+) + 0
                alcian yellow cation + 0
                auramine O(1+) + 37
                beta-saxitoxinol(2+) 0
                brilliant green cation + 8
                carboxamidinium ion + 36
                crystal violet cation + 18
                dehydrocoformycin(1+) 0
                ethyl green(1+) + 0
                ethyl violet cation + 0
                guanidinium ion + 0
                huprine W(1+) 0
                iminium salt + 0
                iodine green(2+) + 0
                magenta II(1+) + 0
                malachite green cation + 11
                malachite green isothiocyanate cation + 0
                methyl green(2+) + 0
                new fuchsin(1+) + 0
                night blue(1+) + 0
                pararosaniline(1+) + 0
                patent blue V 0
                pyronin B(1+) + 0
                pyronin Y cation + 0
                rhod-2(1+) + 0
                rosanilin(1+) + 0
                saxitoxin(2+) 0
                tacrine(1+) 0
                tetramethylrosamine + 0
                tetrodotoxin(1+) 0
                victoria blue 4R(1+) + 0
                victoria blue B(1+) + 0
                victoria blue R(1+) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      p-block molecular entity 19835
                        carbon group molecular entity 19774
                          organic molecular entity 19771
                            organic ion 11451
                              organic cation 8962
                                iminium ion 98
                                  1-piperideinium 0
                                  11-beta-hydroxy-beta-saxitoxinol(2+) 0
                                  11-beta-hydroxysaxitoxin(2+) 0
                                  2-amino-6-(aminomethyl)-5-methylidene-4-oxo-1,4,5,6,7,8-hexahydropteridin-5-ium 0
                                  2-methyl-1-pyrrolinium 0
                                  4-(21-amino-4,9,12-trioxo-16,19-dioxa-5,8,13-triazahenicos-1-yloxy)-malachite green cation 0
                                  Fast green FCF(1+) 0
                                  Guinee green B(1+) 0
                                  Methyl violet 2B(1+) + 0
                                  N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium 0
                                  QSY21 succinimidyl ester(1+) + 0
                                  QSY7 succinimidyl ester(1+) + 0
                                  QSY9 succinimidyl ester(1+) + 0
                                  ToTo-3(4+) + 0
                                  X-rhod-1(1+) + 0
                                  YoYo-3(4+) + 0
                                  acid green 5(1+) 0
                                  acridine red 3B(1+) + 0
                                  alcian yellow cation + 0
                                  auramine O(1+) + 37
                                  beta-saxitoxinol(2+) 0
                                  brilliant green cation + 8
                                  carboxamidinium ion + 36
                                  crystal violet cation + 18
                                  dehydrocoformycin(1+) 0
                                  ethyl green(1+) + 0
                                  ethyl violet cation + 0
                                  guanidinium ion + 0
                                  huprine W(1+) 0
                                  iminium salt + 0
                                  iodine green(2+) + 0
                                  magenta II(1+) + 0
                                  malachite green cation + 11
                                  malachite green isothiocyanate cation + 0
                                  methyl green(2+) + 0
                                  new fuchsin(1+) + 0
                                  night blue(1+) + 0
                                  pararosaniline(1+) + 0
                                  patent blue V 0
                                  pyronin B(1+) + 0
                                  pyronin Y cation + 0
                                  rhod-2(1+) + 0
                                  rosanilin(1+) + 0
                                  saxitoxin(2+) 0
                                  tacrine(1+) 0
                                  tetramethylrosamine + 0
                                  tetrodotoxin(1+) 0
                                  victoria blue 4R(1+) + 0
                                  victoria blue B(1+) + 0
                                  victoria blue R(1+) + 0
paths to the root