sulfonium betaine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	sulfonium betaine	go back to main search page
Accession:	CHEBI:35282	browse the term
Definition:	Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:	related_synonym:	sulfonium betaines

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Genes (95)

S-adenosyl-L-methioninate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor E4

decreases expression

S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA

NCBI chr17:56,056,984...56,160,662
Ensembl chr17:56,056,984...56,160,662

G

adhesion G protein-coupled receptor E5

decreases expression

S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA

NCBI chr 8:84,449,874...84,467,812
Ensembl chr 8:84,449,880...84,467,955

G

alpha fetoprotein

multiple interactions
decreases expression

S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA

NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766

G

aryl-hydrocarbon receptor

multiple interactions
decreases abundance

PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine]

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

aminolevulinate, delta-, dehydratase

increases activity

S-Adenosylmethionine results in increased activity of ALAD protein

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

aminolevulinic acid synthase 2, erythroid

multiple interactions

[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA]

NCBI chr X:149,330,443...149,353,614
Ensembl chr X:149,330,371...149,353,634

G

amyloid beta precursor protein

increases secretion

S-Adenosylmethionine results in increased secretion of APP protein modified form

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

arsenite methyltransferase

multiple interactions
affects binding

Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]

PMID:22955273 PMID:24124590 PMID:25349987

NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538

G

activating transcription factor 3

increases expression

S-Adenosylmethionine results in increased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

ATPase, copper transporting, beta polypeptide

multiple interactions

ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine]

NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321

G

betaine-homocysteine methyltransferase 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U]

NCBI chr13:93,792,605...93,810,810
Ensembl chr13:93,792,228...93,810,810

G

caspase 12

decreases expression

S-Adenosylmethionine results in decreased expression of CASP12 mRNA

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

multiple interactions
decreases activity

S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein

PMID:17869084 PMID:18571630

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

multiple interactions

S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cellular communication network factor 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CCN1 protein]; S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased stability of CCN1 mRNA]

NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736

G

cadherin 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CDH2 protein]

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

collagen, type I, alpha 1

decreases expression
multiple interactions

S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]

PMID:15983038 PMID:16996477

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

multiple interactions
decreases expression

S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA

PMID:8878782 PMID:15983038

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

catechol-O-methyltransferase

multiple interactions

[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]

NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602

G

cytochrome c, somatic

multiple interactions

S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]

PMID:15763544 PMID:15983038 PMID:22683606

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

dopa decarboxylase

multiple interactions

[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine

NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144

G

discs large MAGUK scaffold protein 4

multiple interactions

S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein]

NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348

G

DNA methyltransferase 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein]

NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184

G

DNA methyltransferase 3A

multiple interactions

S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]

PMID:18098314 PMID:22558281

NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443

G

early growth response 1

multiple interactions

[S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

estrogen receptor 1 (alpha)

multiple interactions

S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein]

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

Fc receptor, IgG, high affinity I

decreases expression

S-Adenosylmethionine results in decreased expression of FCGR1 mRNA

NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285

G

fibroblast growth factor 15

increases abundance

FGF19 protein results in increased abundance of S-Adenosylmethionine

NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690

G

fibrinogen-like protein 2

decreases expression

S-Adenosylmethionine results in decreased expression of FGL2 mRNA

NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372

G

guanylate binding protein 2

decreases expression

S-Adenosylmethionine results in decreased expression of GBP2 mRNA

NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

decreases abundance

GCLM protein mutant form results in decreased abundance of S-Adenosylmethionine

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

gene regulated by estrogen in breast cancer protein

multiple interactions

S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA]

NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887

G

glutathione reductase

multiple interactions

S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione synthetase

multiple interactions

S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]

NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730

G

glutathione S-transferase, mu 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

histocompatibility 2, class II antigen E beta

decreases expression

S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

heart and neural crest derivatives expressed 2

multiple interactions

[Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA]

NCBI chr 8:57,774,018...57,777,552
Ensembl chr 8:57,774,018...57,777,668

G

hemoglobin, beta adult major chain

multiple interactions

[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA]

G

histone deacetylase 9

multiple interactions

S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]

NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094

G

hydroxymethylbilane synthase

multiple interactions

[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA]

NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525

G

interferon-induced protein 44 like

decreases expression

S-Adenosylmethionine results in decreased expression of IFI44L mRNA

NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529

G

interferon gamma

multiple interactions

S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 1 beta

multiple interactions

S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

PMID:17080400 PMID:19822164

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA]

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 2 receptor, gamma chain

decreases expression

S-Adenosylmethionine results in decreased expression of IL2RG mRNA

NCBI chr X:100,307,991...100,311,861
Ensembl chr X:100,307,984...100,311,861

G

interleukin 36G

decreases expression

S-Adenosylmethionine results in decreased expression of IL36G mRNA

NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580

G

interleukin 6

multiple interactions

S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]

PMID:17080400 PMID:19822164

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

Kruppel-like transcription factor 6

decreases expression
multiple interactions

S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]

NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393

G

leptin

multiple interactions

S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA]

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

lymphotoxin B

multiple interactions

S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA]

NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296

G

MAF bZIP transcription factor

multiple interactions

S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]

NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

multiple interactions

S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]

NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426

G

mitogen-activated protein kinase 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]

PMID:15983038 PMID:16996477

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]

PMID:15983038 PMID:16996477

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

methionine adenosyltransferase 1A

affects abundance
increases chemical synthesis

MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine

PMID:8373829 PMID:12060674

NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369

G

methionine adenosyltransferase 2A

increases chemical synthesis

MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine

NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541

G

methyl-CpG binding domain protein 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein]

NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202

G

maternally expressed 3

multiple interactions

S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA]

NCBI chr12:109,506,879...109,538,163
Ensembl chr12:109,506,877...109,538,165

G

microRNA 491

multiple interactions

S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of MIR491 mRNA]

NCBI chr 4:88,040,277...88,040,362
Ensembl chr 4:88,040,277...88,040,362

G

matrix metallopeptidase 2

multiple interactions

S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of MMP2 protein]

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

increases abundance

MTHFD1 protein results in increased abundance of S-Adenosylmethionine

NCBI chr12:76,301,180...76,366,594
Ensembl chr12:76,302,072...76,366,577

G

5-methyltetrahydrofolate-homocysteine methyltransferase

affects binding
multiple interactions

S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]

PMID:17477549 PMID:26989453

NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999

G

N-myc downstream regulated gene 1

decreases expression

S-Adenosylmethionine results in decreased expression of NDRG1 mRNA

NCBI chr15:66,801,167...66,841,490
Ensembl chr15:66,801,167...66,841,489

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

[S-Adenosylmethionine co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]

PMID:20146260 PMID:35490796

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

neuroligin 3

multiple interactions

S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter]

NCBI chr X:100,342,785...100,364,956
Ensembl chr X:100,342,774...100,369,569

G

nuclear receptor subfamily 0, group B, member 2

increases abundance

NR0B2 protein results in increased abundance of S-Adenosylmethionine

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

neurexin I

multiple interactions

S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter]

NCBI chr17:90,341,072...91,400,587
Ensembl chr17:90,341,059...91,400,499

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

phosphodiesterase 4B, cAMP specific

multiple interactions

[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]

NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456

G

phosphatidylethanolamine N-methyltransferase

multiple interactions

PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine]

NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315

G

profilin 2

decreases expression

S-Adenosylmethionine results in decreased expression of PFN2 mRNA

NCBI chr 3:57,749,316...57,755,178
Ensembl chr 3:57,749,316...57,755,500

G

proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

increases expression

S-Adenosylmethionine results in increased expression of PSMB8 mRNA

NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428

G

prostaglandin-endoperoxide synthase 1

decreases expression

S-Adenosylmethionine results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[S-Adenosylmethionine co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]] which results in decreased expression of PTGS2 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

decreases expression

S-Adenosylmethionine results in decreased expression of RNASEL mRNA

NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967

G

solute carrier family 19 (folate transporter), member 1

affects abundance

SLC19A1 protein affects the abundance of S-Adenosylmethionine

NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836

G

SET and MYND domain containing 2

affects binding

S-Adenosylmethionine binds to SMYD2 protein

NCBI chr 1:189,612,689...189,654,758
Ensembl chr 1:189,612,689...189,654,560

G

suppressor of cytokine signaling 3

multiple interactions

[S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

superoxide dismutase 1, soluble

multiple interactions

S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein]

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions

S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

trans-acting transcription factor 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

synapsin I

multiple interactions

S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein]

NCBI chr X:20,726,750...20,787,157
Ensembl chr X:20,726,750...20,787,243

G

trefoil factor 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA]

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

G

transferrin receptor

decreases expression

S-Adenosylmethionine results in decreased expression of TFRC mRNA

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor, beta 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tumor necrosis factor

multiple interactions

[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]

PMID:19822164 PMID:21266552

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

thiopurine methyltransferase

multiple interactions

[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]

NCBI chr13:47,175,463...47,196,833
Ensembl chr13:47,175,958...47,198,213

G

transferrin

multiple interactions
increases expression

[S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron

NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643

G

ubiquitin D

multiple interactions

S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]

NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986

G

vimentin

multiple interactions

S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein]
S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of VIM protein]

PMID:26745512 PMID:37682722

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

X-ray repair complementing defective repair in Chinese hamster cells 1

multiple interactions

S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]

NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22327
chemical entity	22326
atom	22322
nonmetal atom	22160
sulfur atom	18799
sulfur molecular entity	18799
sulfonium compound	96
sulfonium betaine	95
(dimethylsulfonio)acetate	0
S,S-dimethyl-beta-propiothetin	0
S-adenosyl-4-methylthio-2-oxobutanoate	0
S-adenosyl-L-methioninate	95
S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion	0
S-methyl-L-methioninate	0
phosphatidylsulfocholine +	0
Path 2
Term	Annotations
CHEBI ontology	22327
subatomic particle	22322
composite particle	22322
hadron	22322
baryon	22322
nucleon	22322
atomic nucleus	22322
atom	22322
main group element atom	22209
p-block element atom	22209
carbon group element atom	22015
carbon atom	21958
organic molecular entity	21958
organic molecule	21791
dipolar compound	472
zwitterion	472
onium betaine	470
sulfonium betaine	95
(dimethylsulfonio)acetate	0
S,S-dimethyl-beta-propiothetin	0
S-adenosyl-4-methylthio-2-oxobutanoate	0
S-adenosyl-L-methioninate	95
S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion	0
S-methyl-L-methioninate	0
phosphatidylsulfocholine +	0

paths to the root