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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfonium betaine
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Accession:CHEBI:35282 term browser browse the term
Definition:Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:related_synonym: sulfonium betaines


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S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRE4P adhesion G protein-coupled receptor E4, pseudogene decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr19:6,950,758...6,997,851
Ensembl chr19:6,954,659...6,990,798 		JBrowse link
G ADGRE5 adhesion G protein-coupled receptor E5 decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr19:14,381,444...14,408,723
Ensembl chr19:14,380,501...14,408,725 		JBrowse link
G AFP alpha fetoprotein multiple interactions
decreases expression		 ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA		 CTD PMID:18098314 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
decreases abundance		 ISO PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ALAD aminolevulinate dehydratase increases activity ISO S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977 		JBrowse link
G APP amyloid beta precursor protein increases secretion EXP S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G AS3MT arsenite methyltransferase multiple interactions
affects binding		 EXP Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:24124590 PMID:25349987 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899 		JBrowse link
G ATF3 activating transcription factor 3 increases expression ISO S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions ISO ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr13:51,932,669...52,012,132
Ensembl chr13:51,930,436...52,012,125 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr 5:79,069,767...79,090,069
Ensembl chr 5:79,069,767...79,090,069 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) decreases expression ISO S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 multiple interactions
decreases activity		 EXP
ISO		 S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein		 CTD PMID:17869084 PMID:18571630 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CAT catalase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCN1 cellular communication network factor 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CCN1 protein]; S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased stability of CCN1 mRNA] CTD PMID:37682722 NCBI chr 1:85,580,761...85,583,950
Ensembl chr 1:85,580,761...85,584,589 		JBrowse link
G CDH2 cadherin 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CDH2 protein] CTD PMID:37682722 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]		 CTD PMID:15983038 PMID:16996477 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions
decreases expression		 ISO
EXP		 S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA		 CTD PMID:8878782 PMID:15983038 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
multiple interactions		 EXP
ISO		 S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]		 CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DDC dopa decarboxylase multiple interactions EXP [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,836 		JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP
ISO		 S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]		 CTD PMID:18098314 PMID:22558281 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter] CTD PMID:35490796 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FCGR1A Fc gamma receptor Ia decreases expression ISO S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675 		JBrowse link
G FGF19 fibroblast growth factor 19 increases abundance ISO FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G FGL2 fibrinogen like 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 7:77,193,369...77,199,819
Ensembl chr 7:77,193,369...77,199,848 		JBrowse link
G GBP2 guanylate binding protein 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 1:89,106,132...89,126,114
Ensembl chr 1:89,106,132...89,150,456 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit decreases abundance ISO GCLM protein mutant form results in decreased abundance of S-Adenosylmethionine CTD PMID:38830566 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr 2:11,482,888...11,642,788
Ensembl chr 2:11,482,341...11,642,788 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSS glutathione synthetase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 multiple interactions ISO [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229 		JBrowse link
G HBB hemoglobin subunit beta multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395 		JBrowse link
G HDAC9 histone deacetylase 9 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HMBS hydroxymethylbilane synthase multiple interactions EXP [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G IFI44L interferon induced protein 44 like decreases expression ISO S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145 		JBrowse link
G IFNG interferon gamma multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]		 CTD PMID:17080400 PMID:19822164 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL2RG interleukin 2 receptor subunit gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:71,107,404...71,111,577
Ensembl chr  X:71,107,404...71,112,108 		JBrowse link
G IL36G interleukin 36 gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 2:112,978,006...112,985,658
Ensembl chr 2:112,973,203...112,985,658 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]		 CTD PMID:17080400 PMID:19822164 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KLF6 KLF transcription factor 6 decreases expression
multiple interactions		 ISO S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]		 CTD PMID:18098314 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281 		JBrowse link
G LEP leptin multiple interactions EXP S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LTB lymphotoxin beta multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522 		JBrowse link
G MAF MAF bZIP transcription factor multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr16:79,202,622...79,600,737
Ensembl chr16:79,585,843...79,600,737 		JBrowse link
G MAFG MAF bZIP transcription factor G multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP		 S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]		 CTD PMID:15983038 PMID:16996477 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO		 [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15983038 PMID:16996477 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAT1A methionine adenosyltransferase 1A affects abundance
increases chemical synthesis		 ISO MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine		 CTD PMID:8373829 PMID:12060674 NCBI chr10:80,271,820...80,289,658
Ensembl chr10:80,271,820...80,289,658 		JBrowse link
G MAT2A methionine adenosyltransferase 2A increases chemical synthesis ISO MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine CTD PMID:8373829 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MBD2 methyl-CpG binding domain protein 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] CTD PMID:22558281 NCBI chr18:54,151,606...54,224,669
Ensembl chr18:54,151,606...54,224,669 		JBrowse link
G MEG3 maternally expressed 3 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA] CTD PMID:33033900 NCBI chr14:100,826,108...100,861,026
Ensembl chr14:100,779,206...100,861,031 		JBrowse link
G MIR491 microRNA 491 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MIR491 mRNA] CTD PMID:24680928 NCBI chr 9:20,716,105...20,716,188
Ensembl chr 9:20,716,105...20,716,188 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of MMP2 protein] CTD PMID:37682722 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 increases abundance ISO MTHFD1 protein results in increased abundance of S-Adenosylmethionine CTD PMID:19033438 NCBI chr14:64,388,353...64,460,025
Ensembl chr14:64,388,031...64,463,457 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions		 EXP S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]		 CTD PMID:17477549 PMID:26989453 NCBI chr 1:236,795,281...236,903,981
Ensembl chr 1:236,795,260...236,921,278 		JBrowse link
G NDRG1 N-myc downstream regulated 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of NDRG1 mRNA CTD PMID:18098314 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [S-Adenosylmethionine co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] CTD PMID:20146260 PMID:35490796 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLGN3 neuroligin 3 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:71,144,841...71,175,307
Ensembl chr  X:71,144,821...71,175,255 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases abundance ISO NR0B2 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NRXN1 neurexin 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr 2:49,918,503...51,032,132
Ensembl chr 2:49,918,503...51,225,575 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA] CTD PMID:35490796 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PDE4B phosphodiesterase 4B multiple interactions ISO [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] CTD PMID:21266552 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr17:17,505,563...17,592,142
Ensembl chr17:17,505,563...17,591,708 		JBrowse link
G PFN2 profilin 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of PFN2 mRNA CTD PMID:18098314 NCBI chr 3:149,964,904...149,970,895
Ensembl chr 3:149,964,904...150,050,788 		JBrowse link
G PRDM7 PR/SET domain 7 affects binding EXP S-Adenosylmethionine binds to PRDM7 protein CTD PMID:27129774 NCBI chr16:90,056,566...90,077,331
Ensembl chr16:90,056,566...90,092,072 		JBrowse link
G PSMB8 proteasome 20S subunit beta 8 increases expression ISO S-Adenosylmethionine results in increased expression of PSMB8 mRNA CTD PMID:18098314 NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of PTGS1 mRNA CTD PMID:18098314 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [S-Adenosylmethionine co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]] which results in decreased expression of PTGS2 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter] CTD PMID:35490796 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:21266552 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RNASEL ribonuclease L decreases expression ISO S-Adenosylmethionine results in decreased expression of RNASEL mRNA CTD PMID:18098314 NCBI chr 1:182,573,634...182,589,256
Ensembl chr 1:182,573,634...182,589,256 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylmethionine CTD PMID:15705887 NCBI chr21:45,502,517...45,563,025
Ensembl chr21:45,493,572...45,573,365 		JBrowse link
G SMYD2 SET and MYND domain containing 2 affects binding EXP S-Adenosylmethionine binds to SMYD2 protein CTD PMID:21782458 NCBI chr 1:214,281,159...214,337,131
Ensembl chr 1:214,281,102...214,337,131 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions EXP [S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter] CTD PMID:35490796 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:22683606 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] CTD PMID:22683606 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP
ISO		 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]		 CTD PMID:15983038 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SYN1 synapsin I multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857 		JBrowse link
G TF transferrin multiple interactions
increases expression		 ISO [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron CTD PMID:18571630 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TFF1 trefoil factor 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] CTD PMID:22558281 NCBI chr21:42,362,282...42,366,535
Ensembl chr21:42,362,282...42,366,535 		JBrowse link
G TFRC transferrin receptor decreases expression ISO S-Adenosylmethionine results in decreased expression of TFRC mRNA CTD PMID:18571630 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP
ISO		 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15983038 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]		 CTD PMID:19822164 PMID:21266552 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TPMT thiopurine S-methyltransferase multiple interactions EXP [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] CTD PMID:20196537 NCBI chr 6:18,128,311...18,155,169
Ensembl chr 6:18,128,311...18,155,077 		JBrowse link
G UBD ubiquitin D multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] CTD PMID:18098314 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732 		JBrowse link
G VIM vimentin multiple interactions ISO
EXP		 S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein]
S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of VIM protein]		 CTD PMID:26745512 PMID:37682722 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA] CTD PMID:35490796 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26559
    chemical entity 26539
      atom 26535
        nonmetal atom 25820
          sulfur atom 20398
            sulfur molecular entity 20398
              sulfonium compound 97
                sulfonium betaine 96
                  (dimethylsulfonio)acetate 0
                  S,S-dimethyl-beta-propiothetin 0
                  S-adenosyl-4-methylthio-2-oxobutanoate 0
                  S-adenosyl-L-methioninate 96
                  S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                  S-methyl-L-methioninate 0
                  phosphatidylsulfocholine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26559
    subatomic particle 26535
      composite particle 26535
        hadron 26535
          baryon 26535
            nucleon 26535
              atomic nucleus 26535
                atom 26535
                  main group element atom 26283
                    p-block element atom 26283
                      carbon group element atom 25735
                        carbon atom 25698
                          organic molecular entity 25698
                            organic molecule 25445
                              dipolar compound 465
                                zwitterion 465
                                  onium betaine 463
                                    sulfonium betaine 96
                                      (dimethylsulfonio)acetate 0
                                      S,S-dimethyl-beta-propiothetin 0
                                      S-adenosyl-4-methylthio-2-oxobutanoate 0
                                      S-adenosyl-L-methioninate 96
                                      S-adenosyl-S-carboxymethyl-L-homocysteine dizwitterion 0
                                      S-methyl-L-methioninate 0
                                      phosphatidylsulfocholine + 0
paths to the root