|
G |
Adgre4 |
adhesion G protein-coupled receptor E4 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 9:9,758,106...9,901,908
Ensembl chr 9:9,760,355...9,900,760
|
|
G |
Adgre5 |
adhesion G protein-coupled receptor E5 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638
|
|
G |
Afp |
alpha-fetoprotein |
multiple interactions decreases expression |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA] S-Adenosylmethionine results in decreased expression of AFP mRNA |
CTD |
PMID:18098314 |
|
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Ahr |
aryl hydrocarbon receptor |
decreases abundance multiple interactions |
ISO |
AHR protein results in decreased abundance of S-Adenosylmethionine PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Alad |
aminolevulinate dehydratase |
increases activity |
ISO |
S-Adenosylmethionine results in increased activity of ALAD protein |
CTD |
PMID:9559101 |
|
NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474
|
|
G |
Alas2 |
5'-aminolevulinate synthase 2 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr X:22,890,650...22,914,046
Ensembl chr X:19,463,171...19,486,519
|
|
G |
App |
amyloid beta precursor protein |
increases secretion |
ISO |
S-Adenosylmethionine results in increased secretion of APP protein modified form |
CTD |
PMID:22906069 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
|
|
G |
As3mt |
arsenite methyltransferase |
multiple interactions affects binding |
ISO |
Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] |
CTD |
PMID:22955273 PMID:24124590 PMID:25349987 |
|
NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872
|
|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of ATF3 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
|
|
G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:22945834 |
|
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
|
|
G |
Bhmt2 |
betaine-homocysteine S-methyltransferase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] |
CTD |
PMID:18230605 |
|
NCBI chr 2:26,630,502...26,647,450
Ensembl chr 2:24,895,533...24,912,475
|
|
G |
Casp12 |
caspase 12 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of CASP12 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
|
|
G |
Casp3 |
caspase 3 |
multiple interactions decreases activity |
ISO EXP |
S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein] S-Adenosylmethionine results in decreased activity of CASP3 protein |
CTD |
PMID:17869084 PMID:18571630 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] |
CTD |
PMID:22683606 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccn1 |
cellular communication network factor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CCN1 protein]; S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased stability of CCN1 mRNA] |
CTD |
PMID:37682722 |
|
NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484
|
|
G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CDH2 protein] |
CTD |
PMID:37682722 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression multiple interactions |
ISO |
S-Adenosylmethionine results in decreased expression of COL1A1 mRNA S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions decreases expression |
ISO EXP |
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter] S-Adenosylmethionine results in decreased expression of COL1A2 mRNA |
CTD |
PMID:8878782 PMID:15983038 |
|
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
|
|
G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] |
CTD |
PMID:16758261 |
|
NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] |
CTD |
PMID:22683606 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity multiple interactions |
ISO EXP |
S-Adenosylmethionine results in decreased activity of CYP2E1 protein S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein] S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol] |
CTD |
PMID:15763544 PMID:15983038 PMID:22683606 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Ddc |
dopa decarboxylase |
multiple interactions |
ISO |
[Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:11445284 |
|
NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208
|
|
G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] |
CTD |
PMID:27624276 |
|
NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
|
|
G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein] S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA] |
CTD |
PMID:18098314 PMID:22558281 |
|
NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687
|
|
G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter] |
CTD |
PMID:35490796 |
|
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] |
CTD |
PMID:22558281 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Fcgr1a |
Fc gamma receptor 1A |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FCGR1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:186,539,941...186,548,941
Ensembl chr 2:183,851,077...183,859,994
|
|
G |
Fgf19 |
fibroblast growth factor 19 |
increases abundance |
ISO |
FGF19 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
|
NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:200,056,644...200,060,287
|
|
G |
Fgl2 |
fibrinogen-like 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of FGL2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 4:14,602,762...14,608,405
Ensembl chr 4:13,710,575...13,716,207
|
|
G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of GBP2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:231,332,284...231,348,571
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] |
CTD |
PMID:20146260 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
decreases abundance |
ISO |
GCLM protein mutant form results in decreased abundance of S-Adenosylmethionine |
CTD |
PMID:38830566 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
|
|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] |
CTD |
PMID:22683606 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gss |
glutathione synthetase |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] |
CTD |
PMID:20146260 |
|
NCBI chr 3:164,508,005...164,538,343
Ensembl chr 3:144,047,850...144,078,198
|
|
G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
|
|
G |
Hand2 |
heart and neural crest derivatives expressed 2 |
multiple interactions |
ISO |
[Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] |
CTD |
PMID:30892605 |
|
NCBI chr16:37,928,145...37,931,488
Ensembl chr16:32,917,823...32,919,891
|
|
G |
Hbb |
hemoglobin subunit beta |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012
|
|
G |
Hdac9 |
histone deacetylase 9 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr 6:56,489,472...57,351,654
Ensembl chr 6:50,763,590...51,625,333
|
|
G |
Hmbs |
hydroxymethylbilane synthase |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] |
CTD |
PMID:24141029 |
|
NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957
|
|
G |
Ifi44l |
interferon-induced protein 44-like |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IFI44L mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
|
|
G |
Il2rg |
interleukin 2 receptor subunit gamma |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IL2RG mRNA |
CTD |
PMID:18098314 |
|
NCBI chr X:70,435,340...70,439,052
Ensembl chr X:66,392,542...66,399,823
|
|
G |
Il36g |
interleukin 36, gamma |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of IL36G mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 3:27,346,675...27,352,839
Ensembl chr 3:6,948,297...6,954,480
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA] |
CTD |
PMID:17080400 PMID:19822164 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Klf6 |
KLF transcription factor 6 |
decreases expression multiple interactions |
ISO |
S-Adenosylmethionine results in decreased expression of KLF6 mRNA S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr17:69,449,483...69,458,478
Ensembl chr17:64,531,463...64,588,570
|
|
G |
Lep |
leptin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] |
CTD |
PMID:16996477 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Ltb |
lymphotoxin beta |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] |
CTD |
PMID:17080400 |
|
NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381
|
|
G |
Maf |
MAF bZIP transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] |
CTD |
PMID:20146260 |
|
NCBI chr19:60,259,200...60,622,145
Ensembl chr19:43,360,342...43,712,365
|
|
G |
Mafg |
MAF bZIP transcription factor G |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] |
CTD |
PMID:20146260 |
|
NCBI chr10:106,401,633...106,410,159
Ensembl chr10:105,903,237...105,912,026
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] [1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] |
CTD |
PMID:15983038 PMID:16996477 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mat1a |
methionine adenosyltransferase 1A |
affects abundance increases chemical synthesis |
ISO |
MAT1A affects the abundance of S-Adenosylmethionine MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 PMID:12060674 |
|
NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274
|
|
G |
Mat2a |
methionine adenosyltransferase 2A |
increases chemical synthesis |
ISO |
MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine |
CTD |
PMID:8373829 |
|
NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:104,488,466...104,495,493
|
|
G |
Mbd2 |
methyl-CpG binding domain protein 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] |
CTD |
PMID:22558281 |
|
NCBI chr18:66,449,196...66,516,112
Ensembl chr18:64,174,002...64,240,794
|
|
G |
Meg3 |
maternally expressed 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA] |
CTD |
PMID:33033900 |
|
NCBI chr 6:134,274,056...134,306,249
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of MMP2 protein] |
CTD |
PMID:37682722 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
increases abundance |
ISO |
MTHFD1 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:19033438 |
|
NCBI chr 6:100,713,510...100,781,013
Ensembl chr 6:94,977,862...95,045,372
|
|
G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
affects binding multiple interactions |
ISO |
S-Adenosylmethionine binds to MTR protein [glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:17477549 PMID:26989453 |
|
NCBI chr17:62,911,705...62,996,544
Ensembl chr17:58,220,071...58,304,822
|
|
G |
Ndrg1 |
N-myc downstream regulated 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of NDRG1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] |
CTD |
PMID:20146260 PMID:35490796 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18404532 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nlgn3 |
neuroligin 3 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr X:70,469,251...70,497,380
Ensembl chr X:66,429,458...66,451,876
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases abundance |
ISO |
NR0B2 protein results in increased abundance of S-Adenosylmethionine |
CTD |
PMID:29416063 |
|
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
|
|
G |
Nrxn1 |
neurexin 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] |
CTD |
PMID:27624276 |
|
NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA] |
CTD |
PMID:35490796 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pde4b |
phosphodiesterase 4B |
multiple interactions |
ISO |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] |
CTD |
PMID:21266552 |
|
NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696
|
|
G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
multiple interactions |
ISO |
PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] |
CTD |
PMID:29416063 |
|
NCBI chr10:45,275,434...45,349,651
Ensembl chr10:44,775,911...44,850,013
|
|
G |
Pfn2 |
profilin 2 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PFN2 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 2:144,217,100...144,222,936
Ensembl chr 2:142,067,104...142,072,938
|
|
G |
Psmb8 |
proteasome 20S subunit beta 8 |
increases expression |
ISO |
S-Adenosylmethionine results in increased expression of PSMB8 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,652,159...4,655,283
|
|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of PTGS1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]] which results in decreased expression of PTGS2 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter] |
CTD |
PMID:35490796 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] |
CTD |
PMID:21266552 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Rnasel |
ribonuclease L |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of RNASEL mRNA |
CTD |
PMID:18098314 |
|
NCBI chr13:68,446,641...68,460,804
Ensembl chr13:65,901,459...65,908,704
|
|
G |
RT1-Db1 |
RT1 class II, locus Db1 |
decreases expression |
ISO |
S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA |
CTD |
PMID:18098314 |
|
NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
|
|
G |
Slc19a1 |
solute carrier family 19 member 1 |
affects abundance |
ISO |
SLC19A1 protein affects the abundance of S-Adenosylmethionine |
CTD |
PMID:15705887 |
|
NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972
|
|
G |
Smyd2 |
SET and MYND domain containing 2 |
affects binding |
ISO |
S-Adenosylmethionine binds to SMYD2 protein |
CTD |
PMID:21782458 |
|
NCBI chr13:103,956,470...103,997,774
Ensembl chr13:101,425,273...101,466,576
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
ISO |
[S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter] |
CTD |
PMID:35490796 |
|
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] |
CTD |
PMID:22683606 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] |
CTD |
PMID:22683606 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] |
CTD |
PMID:15983038 |
|
NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
|
|
G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] |
CTD |
PMID:27624276 |
|
NCBI chr X:3,725,745...3,780,940
Ensembl chr X:1,172,208...1,227,396
|
|
G |
Tf |
transferrin |
multiple interactions increases expression |
EXP |
[S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron |
CTD |
PMID:18571630 |
|
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
|
|
G |
Tff1 |
trefoil factor 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] |
CTD |
PMID:22558281 |
|
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
|
|
G |
Tfrc |
transferrin receptor |
decreases expression |
EXP |
S-Adenosylmethionine results in decreased expression of TFRC mRNA |
CTD |
PMID:18571630 |
|
NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15983038 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein] |
CTD |
PMID:19822164 PMID:21266552 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tpmt |
thiopurine S-methyltransferase |
multiple interactions |
ISO |
[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] |
CTD |
PMID:20196537 |
|
NCBI chr17:17,850,308...17,868,976
Ensembl chr17:17,644,173...17,662,709
|
|
G |
Ubd |
ubiquitin D |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] |
CTD |
PMID:18098314 |
|
NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of VIM protein] |
CTD |
PMID:26745512 PMID:37682722 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
|
|
G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions |
ISO |
S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA] |
CTD |
PMID:35490796 |
|
NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701
|
|