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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:onium betaine
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Accession:CHEBI:35281 term browser browse the term
Definition:Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
Synonyms:exact_synonym: betaines
 related_synonym: onium betaines



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(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression ISO Carnitine results in decreased expression of ACACA protein CTD PMID:25669660 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta decreases expression ISO Carnitine results in decreased expression of ACACB protein CTD PMID:25669660 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Carnitine results in increased expression of ADIPOQ protein CTD PMID:30256492 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions
ISO Carnitine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]
CTD PMID:29186614 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions
ISO Carnitine results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; Carnitine inhibits the reaction [Atrazine results in increased expression of BAX mRNA]; Carnitine inhibits the reaction [Methotrexate results in increased expression of BAX protein]
CTD PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions
increases chemical synthesis
ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]; Ketoglutaric Acids inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; Carnitine inhibits the reaction [Atrazine results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] CTD PMID:23213347 PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] CTD PMID:19491382 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO Carnitine inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Carnitine results in increased expression of CASP3 protein
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]
CTD PMID:19491382 PMID:23213347 PMID:25669660 PMID:26562095 PMID:32478940 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]
CTD PMID:23213347 PMID:32478940 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO Carnitine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA] CTD PMID:16889571 PMID:19294768 PMID:23213347 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CCN2 mRNA] CTD PMID:26581635 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein] CTD PMID:28973641 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of COL1A1 mRNA] CTD PMID:26581635 PMID:28973641 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine] CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Carnitine]
[Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNA; [Genistein co-treated with Carnitine] results in increased expression of CPT1A protein; Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]
CTD PMID:16283381 PMID:16362726 PMID:19854160 PMID:32478940 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions
increases expression
ISO Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]
Carnitine results in increased expression of CPT2 protein
CTD PMID:21816645 PMID:25669660 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB mRNA]; Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB protein] CTD PMID:26581635 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA] CTD PMID:29710542 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:8130774 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart multiple interactions ISO Carnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA] CTD PMID:20470772 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256
JBrowse link
G Fabp9 fatty acid binding protein 9, testis multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 protein] CTD PMID:33965443 NCBI chr 3:10,258,683...10,262,343
Ensembl chr 3:10,258,681...10,262,343
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Carnitine results in decreased expression of FASN protein CTD PMID:25669660 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of FSHB protein] CTD PMID:33965443 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gdf9 growth differentiation factor 9 increases expression
multiple interactions
EXP Carnitine results in increased expression of GDF9 mRNA
Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GDF9 mRNA]
CTD PMID:37863343 NCBI chr11:53,321,773...53,328,731
Ensembl chr11:53,321,850...53,328,731
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in increased expression of GFAP protein] CTD PMID:36282381 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
EXP Carnitine results in increased expression of GJA1 mRNA
Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GJA1 mRNA]
CTD PMID:37863343 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression
multiple interactions
EXP Carnitine results in increased expression of GJA4 mRNA
Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of GJA4 mRNA]
CTD PMID:37863343 NCBI chr 4:127,205,213...127,207,832
Ensembl chr 4:127,205,214...127,207,832
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in increased activity of GPT protein] CTD PMID:36282381 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein] CTD PMID:32478940 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160
JBrowse link
G Has2 hyaluronan synthase 2 increases expression
multiple interactions
EXP Carnitine results in increased expression of HAS2 mRNA
Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of HAS2 mRNA]
CTD PMID:37863343 NCBI chr15:56,529,023...56,557,942
Ensembl chr15:56,529,023...56,557,935
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein] CTD PMID:37312617 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) multiple interactions EXP Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein] CTD PMID:16239342 NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543
JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO Carnitine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA2 protein] CTD PMID:22359436 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of IL10 protein]; Carnitine inhibits the reaction [Sunitinib results in decreased expression of IL10 mRNA] CTD PMID:26581635 PMID:33965443 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il18 interleukin 18 increases expression ISO Carnitine results in increased expression of IL18 protein CTD PMID:25669660 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Carnitine inhibits the reaction [sunitinib results in increased expression of IL1B mRNA]
Carnitine results in increased expression of IL1B protein
CTD PMID:25669660 PMID:26562095 PMID:26581635 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Methotrexate results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Sunitinib results in increased expression of IL6 mRNA] CTD PMID:26581635 PMID:33965443 PMID:37312617 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I decreases uptake
multiple interactions
EXP
ISO
INS1 protein results in decreased uptake of Carnitine
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]
CTD PMID:28298333 PMID:30256492 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Carnitine inhibits the reaction [Doxorubicin results in increased activity of LDHA protein] CTD PMID:37453608 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Carnitine CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of LHB protein] CTD PMID:33965443 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA] CTD PMID:26581635 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased activity of MPO protein] CTD PMID:18597074 PMID:18852009 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] CTD PMID:37312617 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Carnitine results in increased expression of NLRP3 protein CTD PMID:25669660 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of NOS2 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 PMID:33965443 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Carnitine results in increased expression of NOS3 CTD PMID:20123095 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Ocln occludin multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of OCLN protein] CTD PMID:33965443 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity
ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine]; PPARA protein promotes the reaction [Carnitine results in decreased susceptibility to Gentamicins]
Carnitine results in increased expression of PPARA protein
Carnitine results in increased activity of PPARA protein
CTD PMID:19491382 PMID:19735737 PMID:25669660 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO Carnitine results in increased expression of PPARG protein
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]
CTD PMID:30256492 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of PPARGC1A protein] CTD PMID:37312617 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase increases expression
increases response to substance
multiple interactions
ISO Carnitine results in increased expression of PTGIS mRNA
PTGIS protein results in increased susceptibility to Carnitine
[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524
JBrowse link
G Pycard PYD and CARD domain containing increases expression ISO Carnitine results in increased expression of PYCARD protein CTD PMID:25669660 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of RELA protein] CTD PMID:33965443 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO Carnitine results in decreased expression of SCD protein CTD PMID:25669660 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:37312617 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP Carnitine inhibits the reaction [Cyclophosphamide results in increased expression of SIRT3 mRNA] CTD PMID:37863343 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 decreases expression ISO Carnitine results in decreased expression of SLC22A1 protein CTD PMID:25669660 NCBI chr17:12,867,761...12,894,725
Ensembl chr17:12,867,756...12,894,716
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 decreases expression ISO Carnitine results in decreased expression of SLC22A2 protein CTD PMID:25669660 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Slc22a21 solute carrier family 22 (organic cation transporter), member 21 multiple interactions
increases uptake
ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine] CTD PMID:19735737 NCBI chr11:53,840,780...53,871,159
Ensembl chr11:53,840,791...53,871,158
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions
increases uptake
EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Carnitine analog inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Choline inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cimetidine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Corticosterone inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cyclic AMP inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; estrone sulfate inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Salicylic Acid inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; tetramethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 increases uptake
decreases expression
ISO SLC22A4 protein results in increased uptake of Carnitine
Carnitine results in decreased expression of SLC22A4 protein
CTD PMID:21256917 PMID:25669660 PMID:33007874 NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions
affects expression
decreases expression
increases transport
increases uptake
increases expression
affects uptake
affects binding
ISO
EXP
[Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA; Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin]; Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine affects the expression of SLC22A5 protein
Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of and results in increased localization of Doxorubicin]
Carnitine results in decreased expression of SLC22A5 mRNA; Carnitine results in decreased expression of SLC22A5 protein
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine deficiency results in increased expression of SLC22A5 mRNA
SLC22A5 protein results in increased uptake of Carnitine; SLC22A5 protein results in increased uptake of Carnitine analog
SLC22A5 protein affects the uptake of Carnitine
Carnitine binds to SLC22A5 protein
CTD PMID:12644265 PMID:15486076 PMID:16283381 PMID:16928358 PMID:18762717 More... NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases transport EXP SLC22A8 protein results in increased transport of Carnitine CTD PMID:15100168 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199
JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions
increases transport
ISO Ampicillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Carnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cefonicid inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Piperacillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 PMID:23402788 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases expression
ISO Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Carnitine results in increased expression of SLC2A4 protein
CTD PMID:30256492 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein] CTD PMID:28973641 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA]
Carnitine results in decreased expression of SREBF1 protein
CTD PMID:18299183 PMID:25669660 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR protein] CTD PMID:33965443 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TGFB1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of TGFB1 mRNA] CTD PMID:26562095 PMID:26581635 PMID:28973641 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA] CTD PMID:26581635 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein] CTD PMID:28973641 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression
ISO Carnitine deficiency results in increased expression of TNF mRNA
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [carbendazim results in increased expression of TNF protein]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of TNF protein]
Carnitine results in decreased expression of TNF protein
CTD PMID:18597074 PMID:18629605 PMID:18852009 PMID:26562095 PMID:33965443 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Vim vimentin multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VIM protein] CTD PMID:28973641 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein] CTD PMID:19041333 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein] CTD PMID:19041333 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Prnp prion protein multiple interactions
affects folding
ISO Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349
JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322
JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance EXP FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322
JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
JBrowse link
G Smad3 SMAD family member 3 decreases abundance EXP SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276
JBrowse link
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA CTD PMID:16386258 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Cd68 CD68 antigen increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA CTD PMID:16386258 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CXCL8 mRNA CTD PMID:16386258 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] CTD PMID:24079413 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1B mRNA CTD PMID:16386258 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 multiple interactions ISO [KCNAB2 protein co-treated with NADP] results in increased reduction of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine CTD PMID:21296056 NCBI chr 4:152,475,201...152,561,991
Ensembl chr 4:152,475,199...152,562,367
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein
resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]
CTD PMID:24079413 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK3 protein] CTD PMID:24079413 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Ptafr platelet-activating factor receptor affects binding
multiple interactions
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
CTD PMID:16386258 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Sele selectin, endothelial cell increases expression
increases secretion
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of SELE mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of SELE protein
CTD PMID:16386258 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Src Rous sarcoma oncogene multiple interactions
increases phosphorylation
ISO resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein] CTD PMID:24079413 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166
JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TNF mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of TNF protein
CTD PMID:16386258 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase, endothelial increases hydrolysis ISO LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334
JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase, hepatic multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
JBrowse link
G Lipg lipase, endothelial multiple interactions EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334
JBrowse link
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Alox12 arachidonate 12-lipoxygenase increases expression ISO Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
Platelet Activating Factor results in increased expression of ALOX5 mRNA
CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases secretion
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CXCL8 protein] CTD PMID:15149885 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance
ISO Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838
JBrowse link
G Egr1 early growth response 1 increases expression ISO Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
ISO Platelet Activating Factor results in increased expression of IL1B mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]
CTD PMID:16386258 PMID:32830409 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein] CTD PMID:32830409 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Itgam integrin alpha M multiple interactions
increases expression
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 affects response to substance EXP LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr14:56,002,154...56,005,951
Ensembl chr14:56,003,419...56,005,951
JBrowse link
G Mir149 microRNA 149 decreases expression
multiple interactions
ISO Platelet Activating Factor results in decreased expression of MIR149 mRNA
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; [Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA
CTD PMID:32830409 NCBI chr 1:92,778,100...92,778,165
Ensembl chr 1:92,778,100...92,778,165
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions
increases expression
ISO PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein] CTD PMID:32830409 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions EXP NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation
EXP Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128
JBrowse link
G Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) multiple interactions
increases expression
ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding
ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 More... NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pvt1 Pvt1 oncogene increases expression
multiple interactions
ISO Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
CTD PMID:32830409 NCBI chr15:61,909,835...62,132,064
Ensembl chr15:61,888,639...62,249,945
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr 1:169,569,046...169,575,211
Ensembl chr 1:169,569,046...169,575,211
JBrowse link
G Sele selectin, endothelial cell increases expression ISO Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246
JBrowse link
G Sell selectin, lymphocyte multiple interactions
increases secretion
ISO Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750
JBrowse link
G Selp selectin, platelet multiple interactions
increases expression
ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595
JBrowse link
G Timp4 tissue inhibitor of metalloproteinase 4 increases expression ISO Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 6:115,221,405...115,229,166
Ensembl chr 6:115,218,853...115,229,166
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression
ISO
EXP
Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]
CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression ISO platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
3-dehydrocarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
4-(trimethylammonio)butanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions ISO [BBOX1 protein co-treated with Ketoglutaric Acids] results in increased metabolism of gamma-butyrobetaine CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases transport
multiple interactions
affects binding
increases uptake
ISO SLC22A5 protein results in increased transport of pivaloylcarnitine
Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]
pivaloylcarnitine binds to SLC22A5 protein
SLC22A5 protein results in increased uptake of pivaloylcarnitine
CTD PMID:18762717 PMID:19539806 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
JBrowse link
carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-Coenzyme A carboxylase beta decreases expression ISO L-carnitine decreases expression of Acacb mRNA and protein in rat heart RGD PMID:30644033 RGD:329955369 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions
ISO L-carnitine increases expression of Cpt1a mRNA and protein in rat heart
L-carnitine inhibits the reaction [sunitinib decreases expression of Cpt1a mRNA and protein in rat heart]
RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
JBrowse link
G Mlycd malonyl-CoA decarboxylase increases expression
multiple interactions
ISO L-carnitine increases expression of Mlycd protein in rat heart
L-carnitine inhibits the reaction [sunitinib increases expression of Mlycd protein in rat heart]
RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841
JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit increases expression
multiple interactions
ISO L-carnitine increases expression of Ampka2 protein in rat serum and heart
L-carnitine inhibits the reaction [sunitinib decreases expression of Ampka2 protein in rat serum and heart]
RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
JBrowse link
ceftaroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Defb3 defensin beta 3 multiple interactions ISO Ceftaroline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Tobacco Smoke Pollution] results in decreased secretion of DEFB4A protein]; Ceftaroline inhibits the reaction [IL1B protein results in increased expression of DEFB4A mRNA]; Ceftaroline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [IL1B protein results in increased expression of DEFB4A mRNA]]; Ceftaroline inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of and results in decreased secretion of DEFB4A protein]; Ceftaroline inhibits the reaction [Tobacco Smoke Pollution results in decreased secretion of DEFB4A protein] CTD PMID:27397760 PMID:28720485 NCBI chr 8:19,343,377...19,345,355
Ensembl chr 8:19,343,376...19,345,307
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ceftaroline inhibits the reaction [IL1B protein results in increased expression of DEFB4A mRNA]; Ceftaroline inhibits the reaction [Tobacco Smoke Pollution inhibits the reaction [IL1B protein results in increased expression of DEFB4A mRNA]] CTD PMID:27397760 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Ceftaroline inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR2 protein] CTD PMID:27397760 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Ceftaroline inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TLR4 protein] CTD PMID:28720485 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ceftaroline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Tobacco Smoke Pollution] results in increased secretion of TNF protein]; Ceftaroline inhibits the reaction [Tobacco Smoke Pollution results in increased secretion of TNF protein] CTD PMID:28720485 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:33580994 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein] CTD PMID:33580994 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein] CTD PMID:33580994 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:33580994 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:33580994 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] CTD PMID:33580994 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein] CTD PMID:33580994 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33580994 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions EXP
ISO
Ergothioneine inhibits the reaction [SLC22A4 protein results in increased abundance of and results in increased localization of Doxorubicin]
Ergothioneine inhibits the reaction [SLC22A4 protein results in increased abundance of Doxorubicin]
CTD PMID:37453608 NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] CTD PMID:33580994 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA CTD PMID:33549593 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
JBrowse link
G Abi3bp ABI family member 3 binding protein increases expression ISO Betaine results in increased expression of ABI3BP mRNA CTD PMID:26391144 NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA CTD PMID:22648174 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477
JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ACACB mRNA CTD PMID:33549593 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Betaine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ACSL4 mRNA]; Betaine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of ACSL4 protein] CTD PMID:38108610 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531
JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:37840533 PMID:38651543 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
JBrowse link
G Adgrg2 adhesion G protein-coupled receptor G2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ADGRG2 mRNA CTD PMID:33549593 NCBI chr  X:159,173,315...159,281,072
Ensembl chr  X:159,173,686...159,281,066
JBrowse link
G Adss2 adenylosuccinate synthase 2 decreases expression ISO Betaine results in decreased expression of ADSS2 mRNA CTD PMID:26391144 NCBI chr 1:177,590,742...177,624,064
Ensembl chr 1:177,590,528...177,624,077
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression EXP
ISO
Betaine results in decreased expression of AHCY mRNA CTD PMID:22945834 PMID:26391144 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417
JBrowse link
G Akip1 A kinase interacting protein 1 increases expression ISO Betaine results in increased expression of AKIP1 mRNA CTD PMID:26391144 NCBI chr 7:109,302,885...109,311,393
Ensembl chr 7:109,302,897...109,311,396
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases expression ISO Betaine results in decreased expression of AKR1B1 mRNA CTD PMID:26391144 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of AKR1B7 mRNA CTD PMID:33549593 NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077
JBrowse link
G Alb albumin multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in decreased expression of ALB protein] CTD PMID:37840533 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein CTD PMID:20118189 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 decreases expression ISO Betaine results in decreased expression of APEX1 mRNA CTD PMID:26391144 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [Azacitidine results in increased expression of and results in increased cleavage of APP protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein] CTD PMID:19635394 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atp7b ATPase, copper transporting, beta polypeptide multiple interactions EXP ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA] CTD PMID:22945834 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
JBrowse link
G Axin1 axin 1 multiple interactions EXP [Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene CTD PMID:16868943 NCBI chr17:26,350,294...26,414,784
Ensembl chr17:26,357,662...26,414,785
JBrowse link
G Bax BCL2-associated X protein decreases expression ISO Betaine results in decreased expression of BAX protein CTD PMID:25080425 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects binding
increases expression
ISO Betaine analog binds to BCL2 protein
Betaine results in increased expression of BCL2 protein
CTD PMID:25080425 PMID:25765238 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Betaine results in increased expression of BHLHE40 mRNA CTD PMID:26391144 NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886
JBrowse link
G Bhmt betaine-homocysteine methyltransferase increases metabolic processing ISO BHMT protein results in increased metabolism of Betaine CTD PMID:18230605 NCBI chr13:93,753,399...93,774,266
Ensembl chr13:93,753,183...93,774,469
JBrowse link
G Brf1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit multiple interactions ISO Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 mRNA]; Betaine inhibits the reaction [Ethanol results in increased expression of BRF1 protein] CTD PMID:32418914 NCBI chr12:112,919,251...112,964,327
Ensembl chr12:112,923,705...112,964,324
JBrowse link
G Cab39l calcium binding protein 39-like decreases expression ISO Betaine results in decreased expression of CAB39L mRNA CTD PMID:26391144 NCBI chr14:59,678,400...59,786,353
Ensembl chr14:59,678,421...59,823,213
JBrowse link
G Casp1 caspase 1 increases expression ISO Betaine results in increased expression of CASP1 mRNA CTD PMID:26391144 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Betaine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:24632105 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein; Betaine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
Betaine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Betaine inhibits the reaction [Carbon Tetrachloride results in increased activity of CAT protein]; Betaine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
CTD PMID:12893363 PMID:20118189 PMID:24632105 PMID:36087182 PMID:37840533 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccdc113 coiled-coil domain containing 113 increases expression ISO Betaine results in increased expression of CCDC113 mRNA CTD PMID:26391144 NCBI chr 8:96,260,684...96,285,516
Ensembl chr 8:96,260,713...96,285,518
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA CTD PMID:22648174 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Betaine results in increased expression of CCL5 mRNA CTD PMID:26391144 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 increases expression ISO Betaine results in increased expression of CCL6 mRNA CTD PMID:26391144 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Betaine results in decreased expression of CCNB2 mRNA CTD PMID:26391144 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
JBrowse link
G Cd44 CD44 antigen decreases expression ISO Betaine results in decreased expression of CD44 mRNA CTD PMID:26391144 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
JBrowse link
G Cdc42ep2 CDC42 effector protein 2 decreases expression ISO Betaine results in decreased expression of CDC42EP2 mRNA CTD PMID:26391144 NCBI chr19:5,967,584...5,974,844
Ensembl chr19:5,965,664...5,974,844
JBrowse link
G Cdh13 cadherin 13 decreases expression ISO Betaine results in decreased expression of CDH13 mRNA CTD PMID:26391144 NCBI chr 8:119,010,150...120,051,668
Ensembl chr 8:119,010,472...120,051,660
JBrowse link
G Cdk1 cyclin dependent kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA CTD PMID:33549593 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A multiple interactions ISO Betaine promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2A mRNA] CTD PMID:19642983 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
JBrowse link
G Ces2c carboxylesterase 2C multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CES2C mRNA CTD PMID:33549593 NCBI chr 8:105,573,700...105,581,115
Ensembl chr 8:105,573,700...105,581,115
JBrowse link
G Ces3b carboxylesterase 3B increases expression ISO Betaine results in increased expression of CES3 mRNA CTD PMID:26391144 NCBI chr 8:105,810,365...105,820,561
Ensembl chr 8:105,810,385...105,820,561
JBrowse link
G Ckb creatine kinase, brain increases expression ISO Betaine results in increased expression of CKB mRNA CTD PMID:26391144 NCBI chr12:111,635,789...111,638,772
Ensembl chr12:111,635,795...111,638,772
JBrowse link
G Cks1b CDC28 protein kinase 1b decreases expression ISO Betaine results in decreased expression of CKS1B mRNA CTD PMID:26391144 NCBI chr 3:89,322,779...89,325,598
Ensembl chr 3:89,322,779...89,325,690
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CLCF1 mRNA CTD PMID:33549593 NCBI chr19:4,264,479...4,273,548
Ensembl chr19:4,264,292...4,273,544
JBrowse link
G Cotl1 coactosin like F-actin binding protein 1 decreases expression ISO Betaine results in decreased expression of COTL1 mRNA CTD PMID:26391144 NCBI chr 8:120,535,953...120,567,318
Ensembl chr 8:120,535,961...120,567,283
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions
decreases expression
EXP Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in decreased expression of CPT1A mRNA
CTD PMID:22945834 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 decreases expression ISO Betaine results in decreased expression of CXCL16 mRNA CTD PMID:26391144 NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP26A1 mRNA CTD PMID:33549593 NCBI chr19:37,686,186...37,689,984
Ensembl chr19:37,686,246...37,689,984
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2B10 mRNA CTD PMID:33549593 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2C55 mRNA CTD PMID:33549593 NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137
JBrowse link
G Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CYP2D9 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of CYP2D9 mRNA CTD PMID:33549593 NCBI chr15:82,336,578...82,341,028
Ensembl chr15:82,317,638...82,341,046
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
Betaine promotes the reaction [Ethanol results in increased expression of CYP2E1]
CTD PMID:20118189 PMID:21352821 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of CYP4A10 protein CTD PMID:20118189 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 increases expression ISO Betaine results in increased expression of CYSLTR1 mRNA CTD PMID:26391144 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO Betaine results in decreased expression of DAPK1 mRNA CTD PMID:26391144 NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005
JBrowse link
G Depp1 DEPP1 autophagy regulator multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of DEPP1 mRNA CTD PMID:33549593 NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO Betaine results in increased expression of DLX2 mRNA CTD PMID:26391144 NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
increases expression
EXP Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]
Betaine results in increased expression of DNMT1 mRNA
CTD PMID:22945834 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression EXP Betaine results in decreased expression of DNMT3B mRNA CTD PMID:22945834 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650
JBrowse link
G E2f8 E2F transcription factor 8 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of E2F8 mRNA CTD PMID:33549593 NCBI chr 7:48,516,177...48,531,821
Ensembl chr 7:48,516,177...48,531,344
JBrowse link
G Ect2 ect2 oncogene decreases expression ISO Betaine results in decreased expression of ECT2 mRNA CTD PMID:26391144 NCBI chr 3:27,151,371...27,207,971
Ensembl chr 3:27,151,371...27,208,027
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase increases expression ISO Betaine results in increased expression of EEF2K mRNA CTD PMID:26391144 NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGFR mRNA CTD PMID:33549593 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO
EXP
Betaine results in increased expression of EGR1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of EGR1 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Elf3 E74-like factor 3 decreases expression ISO Betaine results in decreased expression of ELF3 mRNA CTD PMID:26391144 NCBI chr 1:135,181,312...135,186,210
Ensembl chr 1:135,181,313...135,186,306
JBrowse link
G Emc9 ER membrane protein complex subunit 9 increases expression ISO Betaine results in increased expression of EMC9 mRNA CTD PMID:26391144 NCBI chr14:55,818,976...55,822,832
Ensembl chr14:55,818,973...55,822,759
JBrowse link
G Ephb6 Eph receptor B6 increases expression ISO Betaine results in increased expression of EPHB6 mRNA CTD PMID:26391144 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of ESCO2 mRNA CTD PMID:33549593 NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443
JBrowse link
G F8 coagulation factor VIII multiple interactions
increases secretion
ISO Betaine affects the localization of and results in increased secretion of F8 protein; Betaine affects the localization of and results in increased secretion of F8 protein mutant form
Betaine results in increased secretion of F8 protein; Betaine results in increased secretion of F8 protein mutant form
CTD PMID:22973456 NCBI chr  X:74,213,950...74,426,342
Ensembl chr  X:74,216,321...74,426,221
JBrowse link
G F9 coagulation factor IX increases secretion ISO Betaine results in increased secretion of F9 protein CTD PMID:22973456 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119
JBrowse link
G Fabp5 fatty acid binding protein 5, epidermal multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of FABP5 mRNA CTD PMID:33549593 NCBI chr 3:10,077,645...10,081,670
Ensembl chr 3:10,077,608...10,081,667
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] CTD PMID:22648174 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression ISO Betaine results in increased expression of FLRT3 mRNA CTD PMID:26391144 NCBI chr 2:140,500,118...140,513,396
Ensembl chr 2:140,492,834...140,513,389
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 decreases expression ISO Betaine results in decreased expression of FXYD2 mRNA; Betaine results in decreased expression of FXYD2 mRNA alternative form CTD PMID:26391144 NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GADD45B mRNA CTD PMID:33549593 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GADD45G mRNA CTD PMID:33549593 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:19294532 NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
JBrowse link
G Gck glucokinase multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GCK mRNA CTD PMID:33549593 NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081
JBrowse link
G Gna14 guanine nucleotide binding protein, alpha 14 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GNA14 mRNA CTD PMID:33549593 NCBI chr19:16,413,031...16,590,706
Ensembl chr19:16,413,126...16,588,184
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression
multiple interactions
ISO
EXP
Betaine results in increased expression of GPCPD1 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of GPCPD1 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr 2:132,371,002...132,420,173
Ensembl chr 2:132,371,002...132,429,649
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Betaine inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Betaine inhibits the reaction [sodium arsenite results in increased activity of GPT protein] CTD PMID:32081044 PMID:36087182 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Betaine inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of GPX4 mRNA]; Betaine inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of GPX4 protein] CTD PMID:38108610 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTA5 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of GSTA5 mRNA CTD PMID:33549593 NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA CTD PMID:33549593 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Betaine inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; Betaine inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:19294532 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890
JBrowse link
G H2az1 H2A.Z variant histone 1 decreases expression ISO Betaine results in decreased expression of H2AZ1 mRNA CTD PMID:26391144 NCBI chr 3:137,570,248...137,572,683
Ensembl chr 3:137,570,248...137,572,683
JBrowse link
G Hip1 huntingtin interacting protein 1 decreases expression ISO Betaine results in decreased expression of HIP1 mRNA CTD PMID:26391144 NCBI chr 5:135,435,350...135,574,167
Ensembl chr 5:135,435,385...135,573,974
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Betaine results in decreased expression of HMGB2 mRNA CTD PMID:26391144 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
Betaine inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
Betaine inhibits the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; Betaine inhibits the reaction [Acetaminophen results in increased expression of HMOX1 protein]
CTD PMID:32081044 PMID:37840533 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hspa5 heat shock protein 5 decreases expression EXP Betaine results in decreased expression of HSPA5 mRNA CTD PMID:22945834 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Betaine results in increased expression of ID2 mRNA CTD PMID:26391144 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA] CTD PMID:37840533 PMID:38651543 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of IRS2 mRNA CTD PMID:33549593 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458
JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression ISO Betaine results in decreased expression of IRX4 mRNA CTD PMID:26391144 NCBI chr13:73,407,708...73,417,741
Ensembl chr13:73,408,598...73,417,727
JBrowse link
G Itga8 integrin alpha 8 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGA8 mRNA CTD PMID:33549593 NCBI chr 2:12,111,443...12,306,755
Ensembl chr 2:12,111,443...12,306,733
JBrowse link
G Itgb4 integrin beta 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ITGB4 mRNA CTD PMID:33549593 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238
JBrowse link
G Jun jun proto-oncogene increases expression ISO Betaine results in increased expression of JUN mRNA CTD PMID:26391144 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 decreases expression ISO Betaine results in decreased expression of KHDRBS3 mRNA CTD PMID:26391144 NCBI chr15:68,800,155...68,973,064
Ensembl chr15:68,800,269...68,973,060
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO Betaine results in increased expression of KIF1B mRNA CTD PMID:26391144 NCBI chr 4:149,260,776...149,392,762
Ensembl chr 4:149,260,776...149,392,150
JBrowse link
G Kif22 kinesin family member 22 decreases expression ISO Betaine results in decreased expression of KIF22 mRNA CTD PMID:26391144 NCBI chr 7:126,626,901...126,641,639
Ensembl chr 7:126,626,901...126,641,643
JBrowse link
G Klf10 Kruppel-like transcription factor 10 increases expression ISO Betaine results in increased expression of KLF10 mRNA CTD PMID:26391144 NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950
JBrowse link
G Krt2 keratin 2 increases expression ISO Betaine results in increased expression of KRT2 mRNA; Betaine results in increased expression of KRT2 protein CTD PMID:26391144 NCBI chr15:101,719,124...101,727,391
Ensembl chr15:101,719,124...101,726,604
JBrowse link
G Krt4 keratin 4 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of KRT4 mRNA CTD PMID:33549593 NCBI chr15:101,826,970...101,833,170
Ensembl chr15:101,826,970...101,833,170
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 decreases expression ISO Betaine results in decreased expression of LARS1 mRNA CTD PMID:26391144 NCBI chr18:42,335,363...42,395,302
Ensembl chr18:42,335,363...42,395,259
JBrowse link
G Lepr leptin receptor multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA CTD PMID:33549593 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lin9 lin-9 DREAM MuvB core complex component decreases expression ISO Betaine results in decreased expression of LIN9 mRNA CTD PMID:26391144 NCBI chr 1:180,468,715...180,518,252
Ensembl chr 1:180,468,715...180,518,259
JBrowse link
G Lratd1 LRAT domain containing 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRATD1 mRNA CTD PMID:33549593 NCBI chr12:14,197,599...14,202,039
Ensembl chr12:14,196,831...14,202,055
JBrowse link
G Lrrc24 leucine rich repeat containing 24 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of LRRC24 mRNA CTD PMID:33549593 NCBI chr15:76,599,476...76,606,373
Ensembl chr15:76,599,476...76,606,373
JBrowse link
G Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MAP4K1 mRNA CTD PMID:33549593 NCBI chr 7:28,681,506...28,702,704
Ensembl chr 7:28,681,475...28,702,704
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 decreases stability
multiple interactions
ISO Betaine results in decreased stability of MARCHF6 protein
Cholesterol inhibits the reaction [Betaine results in decreased stability of MARCHF6 protein]
CTD PMID:30545937 NCBI chr15:31,456,045...31,531,172
Ensembl chr15:31,456,037...31,531,199
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Betaine results in decreased expression of MCM3 mRNA CTD PMID:26391144 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Betaine results in decreased expression of MCM4 mRNA CTD PMID:26391144 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM5 mRNA CTD PMID:33549593 NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MCM6 mRNA CTD PMID:33549593 NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Betaine results in decreased expression of MCM7 mRNA CTD PMID:26391144 NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MICAL1 mRNA CTD PMID:33549593 NCBI chr10:41,351,693...41,363,026
Ensembl chr10:41,352,310...41,363,028
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of MKI67 mRNA CTD PMID:33549593 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Betaine results in decreased expression of MTHFD1L mRNA CTD PMID:26391144 NCBI chr10:3,918,282...4,117,081
Ensembl chr10:3,923,118...4,117,081
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases expression ISO Betaine results in decreased expression of MTHFD2 mRNA CTD PMID:26391144 NCBI chr 6:83,282,686...83,302,926
Ensembl chr 6:83,282,673...83,302,890
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Betaine inhibits the reaction [Diethylnitrosamine results in increased expression of MYC mRNA] CTD PMID:19642983 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of MYCL mRNA CTD PMID:33549593 NCBI chr 4:122,889,414...122,896,278
Ensembl chr 4:122,889,445...122,896,278
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist increases expression ISO Betaine results in increased expression of NBL1 mRNA CTD PMID:26391144 NCBI chr 4:138,809,602...138,820,437
Ensembl chr 4:138,809,595...138,820,304
JBrowse link
G Nckipsd NCK interacting protein with SH3 domain decreases expression ISO Betaine results in decreased expression of NCKIPSD mRNA CTD PMID:26391144 NCBI chr 9:108,685,515...108,696,044
Ensembl chr 9:108,685,567...108,696,043
JBrowse link
G Ndrg4 N-myc downstream regulated gene 4 decreases expression ISO Betaine results in decreased expression of NDRG4 mRNA CTD PMID:26391144 NCBI chr 8:96,403,602...96,441,584
Ensembl chr 8:96,403,608...96,441,747
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP
Betaine inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA]; Betaine inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 protein]
Betaine inhibits the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]; Betaine inhibits the reaction [Acetaminophen results in increased expression of NFE2L2 protein]
CTD PMID:32081044 PMID:37840533 PMID:38651543 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of NLRP12 mRNA CTD PMID:33549593 NCBI chr 7:3,267,317...3,298,400
Ensembl chr 7:3,267,458...3,298,370
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of NLRP3 mRNA] CTD PMID:37840533 PMID:38651543 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 decreases expression ISO Betaine results in decreased expression of NUPR1 mRNA CTD PMID:26391144 NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter] CTD PMID:22064374 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029
JBrowse link
G Pcp4 Purkinje cell protein 4 increases expression ISO Betaine results in increased expression of PCP4 mRNA CTD PMID:26391144 NCBI chr16:96,268,806...96,326,993
Ensembl chr16:96,268,806...96,326,993
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Betaine results in decreased expression of PCTP mRNA CTD PMID:26391144 NCBI chr11:89,873,370...89,893,720
Ensembl chr11:89,873,491...89,893,720
JBrowse link
G Per2 period circadian clock 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of PER2 mRNA CTD PMID:33549593 NCBI chr 1:91,343,699...91,387,028
Ensembl chr 1:91,343,704...91,387,046
JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] CTD PMID:38651543 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Pola2 polymerase (DNA directed), alpha 2 decreases expression ISO Betaine results in decreased expression of POLA2 mRNA CTD PMID:26391144 NCBI chr19:5,990,574...6,014,266
Ensembl chr19:5,990,570...6,014,230
JBrowse link
G Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) decreases expression ISO Betaine results in decreased expression of POLE2 mRNA CTD PMID:26391144 NCBI chr12:69,248,547...69,274,979
Ensembl chr12:69,248,547...69,274,969
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein
Betaine results in decreased expression of PPARA mRNA
CTD PMID:20118189 PMID:22945834 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of PPP1R3G mRNA CTD PMID:33549593 NCBI chr13:36,142,816...36,154,371
Ensembl chr13:36,142,822...36,154,371
JBrowse link
G Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform multiple interactions EXP Betaine inhibits the reaction [Ethanol results in decreased methylation of PPP2CA protein] CTD PMID:32492475 NCBI chr11:51,989,651...52,013,576
Ensembl chr11:51,989,508...52,018,605
JBrowse link
G Prss23 serine protease 23 increases expression ISO Betaine results in increased expression of PRSS23 mRNA CTD PMID:26391144 NCBI chr 7:89,156,988...89,176,399
Ensembl chr 7:89,156,991...89,176,395
JBrowse link
G Prss8 serine protease 8 (prostasin) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of PRSS8 mRNA CTD PMID:33549593 NCBI chr 7:127,524,889...127,529,266
Ensembl chr 7:127,524,888...127,529,276
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP Betaine inhibits the reaction [Azacitidine results in decreased methylation of PSEN1 promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter] CTD PMID:19635394 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Betaine results in decreased expression of PTGS1 mRNA CTD PMID:26391144 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ranbp3l RAN binding protein 3-like decreases expression ISO Betaine results in decreased expression of RANBP3L mRNA CTD PMID:26391144 NCBI chr15:8,997,209...9,071,355
Ensembl chr15:8,997,433...9,067,417
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Betaine inhibits the reaction [Fructose results in decreased activity of RELA protein] CTD PMID:25559852 PMID:38651543 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rfx4 regulatory factor X, 4 (influences HLA class II expression) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RFX4 mRNA CTD PMID:33549593 NCBI chr10:84,591,895...84,742,402
Ensembl chr10:84,591,926...84,742,402
JBrowse link
G Rgs16 regulator of G-protein signaling 16 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of RGS16 mRNA CTD PMID:33549593 NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214
JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression ISO Betaine results in increased expression of RGS2 mRNA CTD PMID:26391144 NCBI chr 1:143,875,076...143,879,887
Ensembl chr 1:143,875,076...143,879,899
JBrowse link
G Rrm2 ribonucleotide reductase M2 decreases expression
multiple interactions
ISO
EXP
Betaine results in decreased expression of RRM2 mRNA
[Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of RRM2 mRNA
CTD PMID:26391144 PMID:33549593 NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of S100A8 mRNA CTD PMID:33549593 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression ISO Betaine results in decreased expression of SCD1 mRNA CTD PMID:26391144 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sectm1a secreted and transmembrane 1A increases expression ISO Betaine results in increased expression of SECTM1A mRNA CTD PMID:26391144 NCBI chr11:120,958,221...120,988,023
Ensembl chr11:120,958,233...120,972,046
JBrowse link
G Serinc2 serine incorporator 2 decreases expression ISO Betaine results in decreased expression of SERINC2 mRNA CTD PMID:26391144 NCBI chr 4:130,147,289...130,172,993
Ensembl chr 4:130,147,288...130,172,998
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Betaine results in decreased expression of SERPINA3N mRNA CTD PMID:26391144 NCBI chr12:104,372,967...104,380,588
Ensembl chr12:104,372,988...104,380,588
JBrowse link
G Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 increases expression ISO Betaine results in increased expression of SLC16A6 mRNA CTD PMID:26391144 NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP Betaine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions ISO Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
JBrowse link
G Slc25a30 solute carrier family 25, member 30 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SLC25A30 mRNA CTD PMID:33549593 NCBI chr14:75,994,986...76,024,477
Ensembl chr14:75,997,557...76,024,477
JBrowse link
G Slc36a1 solute carrier family 36 (proton/amino acid symporter), member 1 increases uptake EXP SLC36A1 protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr11:55,095,148...55,127,156
Ensembl chr11:55,095,176...55,127,156
JBrowse link
G Slc6a12 solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 multiple interactions EXP Betaine inhibits the reaction [Lipopolysaccharides results in increased expression of SLC6A12 mRNA] CTD PMID:22053950 NCBI chr 6:121,319,533...121,342,732
Ensembl chr 6:121,320,035...121,342,734
JBrowse link
G Slc6a20b solute carrier family 6 (neurotransmitter transporter), member 20B increases uptake EXP SLC6A20B protein results in increased uptake of Betaine CTD PMID:18845132 NCBI chr 9:123,422,888...123,461,603
Ensembl chr 9:123,419,865...123,461,630
JBrowse link
G Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 decreases expression ISO Betaine results in decreased expression of SLC6A9 mRNA CTD PMID:26391144 NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395
JBrowse link
G Snx10 sorting nexin 10 decreases expression ISO Betaine results in decreased expression of SNX10 mRNA CTD PMID:26391144 NCBI chr 6:51,500,882...51,567,659
Ensembl chr 6:51,500,881...51,567,659
JBrowse link
G Socs2 suppressor of cytokine signaling 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of SOCS2 mRNA CTD PMID:33549593 NCBI chr10:95,219,765...95,253,176
Ensembl chr10:95,221,224...95,253,042
JBrowse link
G Sostdc1 sclerostin domain containing 1 increases expression ISO Betaine results in increased expression of SOSTDC1 mRNA CTD PMID:26391144 NCBI chr12:36,364,168...36,368,451
Ensembl chr12:36,364,138...36,368,451
JBrowse link
G Spc25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) decreases expression ISO Betaine results in decreased expression of SPC25 mRNA CTD PMID:26391144 NCBI chr 2:69,009,753...69,036,583
Ensembl chr 2:69,024,239...69,036,538
JBrowse link
G Ssr4 signal sequence receptor, delta decreases expression ISO Betaine results in decreased expression of SSR4 mRNA CTD PMID:26391144 NCBI chr  X:72,830,778...72,834,432
Ensembl chr  X:72,830,634...72,834,436
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Betaine promotes the reaction [Isoproterenol results in increased phosphorylation of STAT3 protein] CTD PMID:25080425 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
JBrowse link
G Stmn1 stathmin 1 decreases expression ISO Betaine results in decreased expression of STMN1 mRNA CTD PMID:26391144 NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Betaine results in decreased expression of STXBP1 mRNA CTD PMID:26391144 NCBI chr 2:32,677,619...32,737,249
Ensembl chr 2:32,677,614...32,737,257
JBrowse link
G Sult1e1 sulfotransferase family 1E, member 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of SULT1E1 mRNA CTD PMID:33549593 NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of TAB1 mRNA] CTD PMID:37840533 PMID:38651543 NCBI chr15:80,017,333...80,045,908
Ensembl chr15:80,017,328...80,045,908
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Betaine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TFRC mRNA]; Betaine inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of TFRC protein] CTD PMID:38108610 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Betaine results in increased expression of TGFB2 mRNA CTD PMID:26391144 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased expression of TLR4 mRNA] CTD PMID:37840533 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
Betaine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Betaine inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Betaine inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]
CTD PMID:22945834 PMID:36087182 PMID:37840533 PMID:38651543 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trib2 tribbles pseudokinase 2 decreases expression ISO Betaine results in decreased expression of TRIB2 mRNA CTD PMID:26391144 NCBI chr12:15,841,726...15,866,963
Ensembl chr12:15,841,728...15,866,923
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Betaine inhibits the reaction [Doxorubicin results in increased phosphorylation of TP53 protein] CTD PMID:38651543 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Ulk1 unc-51 like kinase 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of ULK1 mRNA CTD PMID:33549593 NCBI chr 5:110,932,355...110,957,991
Ensembl chr 5:110,932,354...110,957,963
JBrowse link
G Upk3bl uroplakin 3B-like decreases expression ISO Betaine results in decreased expression of UPK3BL1 mRNA CTD PMID:26391144 NCBI chr 5:136,086,114...136,105,549
Ensembl chr 5:136,083,346...136,093,180
JBrowse link
G Usp2 ubiquitin specific peptidase 2 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in increased expression of USP2 mRNA CTD PMID:33549593 NCBI chr 9:43,978,318...44,006,924
Ensembl chr 9:43,978,318...44,006,924
JBrowse link
G Vnn1 vanin 1 multiple interactions EXP [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of VNN1 mRNA CTD PMID:33549593 NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241
JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 decreases expression ISO Betaine results in decreased expression of WNK4 mRNA CTD PMID:26391144 NCBI chr11:101,151,363...101,168,235
Ensembl chr11:101,151,393...101,168,235
JBrowse link
G Ybx2 Y box protein 2 decreases expression ISO Betaine results in decreased expression of YBX2 mRNA CTD PMID:26391144 NCBI chr11:69,826,652...69,832,430
Ensembl chr11:69,826,622...69,832,431
JBrowse link
L-proline betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein] CTD PMID:32417162 NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein] CTD PMID:32417162 NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS4 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of ADAMTS5 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:32417162 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein] CTD PMID:32417162 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:32417162 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein] CTD PMID:32417162 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:32417162 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:32417162 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein] CTD PMID:32417162 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stachydrine inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:32417162 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
meldonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-Coenzyme A dehydrogenase, long-chain increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of ACADL mRNA CTD PMID:32389661 NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of ACADM mRNA CTD PMID:32389661 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACADVL mRNA CTD PMID:32389661 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237
JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of ACOX1 mRNA CTD PMID:32389661 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1B mRNA CTD PMID:32389661 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c decreases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of CPT1C mRNA CTD PMID:32389661 NCBI chr 7:44,607,907...44,624,304
Ensembl chr 7:44,608,796...44,624,275
JBrowse link
G Hk1 hexokinase 1 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of HK1 mRNA CTD PMID:32389661 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of PDK1 mRNA CTD PMID:32389661 NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARA mRNA CTD PMID:32389661 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha decreases expression ISO
EXP
3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of PPARGC1A mRNA CTD PMID:27559315 PMID:32389661 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta affects expression ISO 3-(2,2,2-trimethylhydrazine)propionate affects the expression of PPARGC1B mRNA CTD PMID:27559315 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases uptake ISO SLC22A5 protein results in increased uptake of 3-(2,2,2-trimethylhydrazine)propionate CTD PMID:18981167 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 increases expression EXP 3-(2,2,2-trimethylhydrazine)propionate results in increased expression of SLC2A4 mRNA CTD PMID:32389661 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
JBrowse link
G Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 affects expression EXP 3-(2,2,2-trimethylhydrazine)propionate affects the expression of SLC5A2 mRNA CTD PMID:32389661 NCBI chr 7:127,864,855...127,871,602
Ensembl chr 7:127,864,829...127,871,602
JBrowse link
G Tfam transcription factor A, mitochondrial decreases expression ISO 3-(2,2,2-trimethylhydrazine)propionate results in decreased expression of TFAM mRNA CTD PMID:27559315 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110
JBrowse link
N-methylnicotinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO
EXP
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of ACE mRNA]]; trigonelline inhibits the reaction [Glucose results in increased expression of ACE mRNA]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]; trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]
CTD PMID:29211853 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO
EXP
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]]; trigonelline inhibits the reaction [Glucose results in decreased expression of ACE2 mRNA]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]]; trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]
CTD PMID:29211853 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416
JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of AGT mRNA]]; trigonelline inhibits the reaction [Glucose results in increased expression of AGT mRNA]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]]; trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]
CTD PMID:29211853 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP
ISO
trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of ATG7 protein]
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]]; ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of ATG7 protein]
CTD PMID:30208301 NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein]
[trigonelline co-treated with Cisplatin] results in increased expression of BAX protein; [trigonelline co-treated with Etoposide] results in increased expression of BAX protein
CTD PMID:31935362 PMID:33148531 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]
[trigonelline co-treated with Cisplatin] results in decreased expression of BCL2 protein; [trigonelline co-treated with Etoposide] results in decreased expression of BCL2 protein
CTD PMID:31935362 PMID:33148531 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP
ISO
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in decreased expression of BECN1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in decreased expression of BECN1 protein] CTD PMID:30208301 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP
ISO
trigonelline results in increased activity of CASP3 protein
[trigonelline co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [trigonelline co-treated with Etoposide] results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]
CTD PMID:26593444 PMID:31935362 PMID:33148531 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of CD36 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of CD36 protein] CTD PMID:30208301 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of DDIT3 mRNA CTD PMID:29959986 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Egf epidermal growth factor multiple interactions ISO trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of NFE2L2 protein] CTD PMID:33148531 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation
multiple interactions
ISO trigonelline results in decreased phosphorylation of EGFR protein
trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
CTD PMID:33148531 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:30208301 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTH1 mRNA CTD PMID:29959986 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
JBrowse link
G Ftl1 ferritin light polypeptide 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in increased expression of FTL mRNA CTD PMID:29959986 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] CTD PMID:24015256 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Hexb hexosaminidase B multiple interactions ISO trigonelline inhibits the reaction [iodixanol results in increased secretion of HEXB protein] CTD PMID:34774977 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO trigonelline results in decreased expression of HMOX1 mRNA; trigonelline results in decreased expression of HMOX1 protein CTD PMID:33148531 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased expression of HSPA5 protein] CTD PMID:30208301 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein] CTD PMID:31935362 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL6 protein] CTD PMID:31935362 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Ins1 insulin I multiple interactions EXP trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of INS1 protein] CTD PMID:30208301 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
JBrowse link
G Ins2 insulin II multiple interactions EXP oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]]; trigonelline affects the reaction [INS2 protein affects the expression of ACE mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of ACE protein]; trigonelline affects the reaction [INS2 protein affects the expression of ACE2 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of ACE2 protein]; trigonelline affects the reaction [INS2 protein affects the expression of AGT mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of AGT protein]; trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]; trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]; trigonelline inhibits the reaction [INS2 protein affects the abundance of angiotensin I (1-7)] CTD PMID:29211853 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO [trigonelline co-treated with ferric citrate] results in decreased expression of KEAP1 mRNA CTD PMID:29959986 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of trigonelline CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
trigonelline results in decreased phosphorylation of MAPK1 protein
CTD PMID:33148531 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
trigonelline results in decreased phosphorylation of MAPK3 protein
CTD PMID:33148531 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mas1 MAS1 oncogene multiple interactions EXP
ISO
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]]; oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]]; trigonelline affects the reaction [INS2 protein affects the expression of MAS1 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of MAS1 protein]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in decreased expression of MAS1 mRNA]]; trigonelline inhibits the reaction [Glucose results in decreased expression of MAS1 mRNA]
CTD PMID:29211853 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased phosphorylation of MTOR protein] CTD PMID:30208301 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Myc myelocytomatosis oncogene decreases expression EXP trigonelline results in decreased expression of MYC mRNA CTD PMID:26593444 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases phosphorylation
ISO
EXP
trigonelline inhibits the reaction [EGF protein results in increased phosphorylation of NFE2L2 protein]; trigonelline inhibits the reaction [ferric citrate affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Cisplatin]; trigonelline inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Etoposide]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein]]; trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein]
oltipraz affects the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]]; oltipraz inhibits the reaction [trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]]; trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 mRNA]; trigonelline affects the reaction [INS2 protein affects the expression of NFE2L2 protein]
trigonelline results in decreased phosphorylation of NFE2L2 protein
CTD PMID:24015256 PMID:29211853 PMID:29959986 PMID:33148531 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
decreases expression
ISO trigonelline inhibits the reaction [ferric citrate results in increased expression of NQO1 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
trigonelline results in decreased expression of NQO1 mRNA; trigonelline results in decreased expression of NQO1 protein
CTD PMID:24015256 PMID:29959986 PMID:33148531 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions EXP
ISO
trigonelline inhibits the reaction [Palmitic Acid results in increased cleavage of PARP1 protein]
[trigonelline co-treated with Cisplatin] results in increased cleavage of PARP1 protein; [trigonelline co-treated with Etoposide] results in increased cleavage of PARP1 protein
CTD PMID:30208301 PMID:33148531 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions ISO trigonelline inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein] CTD PMID:34774977 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680
JBrowse link
G Plin1 perilipin 1 multiple interactions EXP trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PLIN1 protein] CTD PMID:30208301 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of PPARG protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of PPARG protein]
CTD PMID:30208301 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects abundance EXP SLCO1A1 protein affects the abundance of trigonelline CTD PMID:21561886 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO
EXP
trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of SQSTM1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SQSTM1 protein]
CTD PMID:30208301 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP
ISO
trigonelline inhibits the reaction [[Cholesterol, Dietary co-treated with Dietary Fats] results in increased expression of SREBF1 protein]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]
ATG7 protein affects the reaction [trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; trigonelline inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]
CTD PMID:30208301 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]]; trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein] CTD PMID:31935362 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression ISO Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596
JBrowse link
G Atp6v1f ATPase, H+ transporting, lysosomal V1 subunit F increases expression ISO Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 6:29,467,782...29,470,508
Ensembl chr 6:29,467,717...29,470,511
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Cs citrate synthase decreases activity ISO Acetylcarnitine results in decreased activity of CS protein CTD PMID:9821151 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348
JBrowse link
G Csprs component of Sp100-rs decreases expression EXP Acetylcarnitine results in decreased expression of CSPRS mRNA CTD PMID:19555370
G Ctss cathepsin S decreases expression EXP Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression EXP Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
JBrowse link
G Gsr glutathione reductase multiple interactions EXP Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606
JBrowse link
G Hspb1 heat shock protein 1 decreases expression ISO Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]
CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Acetylcarnitine results in decreased expression of LYZ1 mRNA CTD PMID:19555370 NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998
JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions
ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
CTD PMID:20414966 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248
JBrowse link
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 increases expression ISO Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr11:70,416,116...70,418,684
Ensembl chr11:70,416,193...70,418,684
JBrowse link
G Ptma prothymosin alpha increases expression ISO Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rps17 ribosomal protein S17 increases expression ISO Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 7:80,992,481...80,994,982
Ensembl chr 7:80,992,480...80,995,002
JBrowse link
G Skap2 src family associated phosphoprotein 2 decreases expression EXP Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392
JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions ISO Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840
JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228
JBrowse link
O-butanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions
EXP IDH2 protein mutant form results in increased abundance of butyrylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine]
CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
O-octanoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crot carnitine O-octanoyltransferase increases chemical synthesis EXP CROT protein results in increased chemical synthesis of octanoylcarnitine CTD PMID:6838215 NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324
JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392
JBrowse link
O-palmitoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Palmitoylcarnitine CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
JBrowse link
G Gls glutaminase increases chemical synthesis ISO GLS protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) decreases metabolic processing EXP PPP3R1 gene mutant form results in decreased metabolism of Palmitoylcarnitine CTD PMID:19700627 NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases chemical synthesis ISO PRKAA1 protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
O-propanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions
ISO
EXP
APP protein mutant form results in increased abundance of propionylcarnitine
[APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of propionylcarnitine]
CTD PMID:39172838 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
decreases abundance
ISO PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased abundance of propionylcarnitine] CTD PMID:39172838 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in decreased abundance of propionylcarnitine CTD PMID:39172838 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
ISO
EXP
[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein
CTD PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein
CTD PMID:15781658 PMID:25416439 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with Vorinostat] results in increased activity of CASP8 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form] CTD PMID:15781658 PMID:32587277 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO perifosine inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein] CTD PMID:34624459 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO
EXP
[perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
perifosine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of FOXO1 protein]
CTD PMID:30265530 PMID:33078829 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO perifosine inhibits the reaction [Mitomycin results in increased activity of GLB1 protein] CTD PMID:34624459 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966
JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases response to substance
decreases expression
ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]
LAT2 protein results in decreased susceptibility to perifosine
CTD PMID:23001822 PMID:32587277 NCBI chr 5:134,628,957...134,648,637
Ensembl chr 5:134,628,876...134,643,879
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
ISO perifosine results in increased cleavage of PARP1 protein
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]
CTD PMID:32587277 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 increases secretion EXP ABCB11 protein results in increased secretion of Phosphatidylcholines CTD PMID:14570929 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects export
affects transport
ISO ABCB1 protein affects the export of Phosphatidylcholines
ABCB1 protein affects the transport of Phosphatidylcholines
CTD PMID:11147995 PMID:11745043 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 affects transport
affects export
EXP
ISO
ABCB4 protein affects the transport of Phosphatidylcholines
ABCB4 protein affects the export of Phosphatidylcholines
CTD PMID:11745043 PMID:15696852 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 decreases activity ISO Phosphatidylcholines results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP Phosphatidylcholines results in decreased expression of ADIPOQ mRNA CTD PMID:23911798 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance
EXP
ISO
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 protein CTD PMID:21695227 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G As3mt arsenite methyltransferase affects metabolic processing EXP AS3MT gene mutant form affects the metabolism of Phosphatidylcholines CTD PMID:27591999 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of BAX protein CTD PMID:21695227 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of BCL2 protein CTD PMID:21695227 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 increases abundance EXP BMAL1 gene mutant form results in increased abundance of Phosphatidylcholines CTD PMID:27056296 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP3 protein CTD PMID:21695227 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP9 protein CTD PMID:21695227 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Phosphatidylcholines results in increased expression of CCL2 mRNA CTD PMID:23911798 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CCND1 protein CTD PMID:21695227 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Phosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein] CTD PMID:21695227 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein CTD PMID:21695227 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1A protein CTD PMID:21695227 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein CTD PMID:21695227 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP Phosphatidylcholines results in decreased expression of CES1D mRNA CTD PMID:23911798 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Crp C-reactive protein, pentraxin-related affects binding
decreases activity
ISO CRP protein binds to Phosphatidylcholines
Phosphatidylcholines results in decreased activity of CRP protein
CTD PMID:16962105 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO Phosphatidylcholines affects the activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases activity ISO Phosphatidylcholines results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Phosphatidylcholines CTD PMID:12885774 NCBI chr11:118,879,007...118,884,047
Ensembl chr11:118,879,014...118,884,047
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines CTD PMID:18723500 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase increases activity ISO Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444
JBrowse link
G Igf1 insulin-like growth factor 1 increases degradation EXP IGF1 protein results in increased degradation of Phosphatidylcholines CTD PMID:2120207 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Il10 interleukin 10 increases expression EXP Phosphatidylcholines results in increased expression of IL10 mRNA CTD PMID:23911798 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Phosphatidylcholines results in increased expression of IL1B mRNA
Phosphatidylcholines results in increased expression of and results in increased secretion of IL1B protein
CTD PMID:23911798 PMID:30958839 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il6 interleukin 6 increases expression EXP Phosphatidylcholines results in increased expression of IL6 mRNA CTD PMID:23911798 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Lep leptin decreases expression EXP Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lipc lipase, hepatic multiple interactions
increases abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPC gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508
JBrowse link
G Lipe lipase, hormone sensitive increases expression EXP Phosphatidylcholines results in increased expression of LIPE mRNA CTD PMID:23911798 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135
JBrowse link
G Lipg lipase, endothelial multiple interactions
increases abundance
EXP [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPG gene mutant form results in increased abundance of Phosphatidylcholines
CTD PMID:24777581 NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334
JBrowse link
G Ltf lactotransferrin multiple interactions EXP [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA] CTD PMID:16169303 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions EXP [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 multiple interactions
increases secretion
ISO PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]; PAFAH1B1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Phosphatidylcholines]
PAFAH1B1 protein results in increased secretion of Phosphatidylcholines
CTD PMID:12013527 NCBI chr11:74,564,775...74,615,210
Ensembl chr11:74,564,775...74,615,496
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 multiple interactions ISO PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 4:134,123,631...134,154,723
Ensembl chr 4:134,123,631...134,154,724
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform multiple interactions ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr16:32,249,739...32,293,883
Ensembl chr16:32,249,739...32,293,888
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO
EXP
PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315
JBrowse link
G Plin1 perilipin 1 increases expression EXP Phosphatidylcholines results in increased expression of PLIN1 mRNA CTD PMID:23911798 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651
JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions
increases chemical synthesis
ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr19:28,941,320...28,944,201
Ensembl chr19:28,941,353...28,944,211
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression EXP Phosphatidylcholines results in decreased expression of PNPLA2 mRNA CTD PMID:23911798 NCBI chr 7:141,035,101...141,040,656
Ensembl chr 7:141,035,111...141,040,656
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Phosphatidylcholines CTD PMID:36336212 NCBI chr 8:3,565,341...3,594,267
Ensembl chr 8:3,565,384...3,594,267
JBrowse link
G Pon2 paraoxonase 2 increases activity
increases expression
EXP Phosphatidylcholines results in increased activity of PON2 protein
Phosphatidylcholines results in increased expression of PON2 mRNA
CTD PMID:12615656 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455
JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression EXP Phosphatidylcholines results in increased expression of PPARG mRNA CTD PMID:23911798 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases abundance EXP PPARGC1B results in increased abundance of Phosphatidylcholines CTD PMID:17932310 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502
JBrowse link
G Pten phosphatase and tensin homolog affects binding
multiple interactions
ISO PTEN protein binds to Phosphatidylcholines
[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]
CTD PMID:15313215 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560
JBrowse link
G Retn resistin decreases expression EXP Phosphatidylcholines results in decreased expression of RETN mRNA CTD PMID:23911798 NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110
JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases abundance
ISO
EXP
GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]
Phosphatidylcholines results in increased expression of TNF mRNA
[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phosphatidylcholines results in increased expression of and results in increased secretion of TNF protein
CTD PMID:16141546 PMID:22433871 PMID:23911798 PMID:30958839 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Phosphatidylcholines inhibits the reaction [rubitecan results in increased expression of TP53 protein] CTD PMID:21695227 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411
JBrowse link
pyocyanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor increases expression
multiple interactions
EXP
ISO
Pyocyanine results in increased expression of AHR mRNA
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter]
CTD PMID:28476168 PMID:31078726 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:24015256 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Atf6 activating transcription factor 6 increases activity ISO Pyocyanine results in increased activity of ATF6 protein CTD PMID:27613716 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression EXP Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein CTD PMID:31078726 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Ctnnb1 catenin beta 1 increases expression EXP Pyocyanine results in increased expression of CTNNB1 mRNA CTD PMID:31078726 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Pyocyanine results in increased expression of CYP1A1 mRNA CTD PMID:31078726 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation ISO Pyocyanine results in increased phosphorylation of EGFR protein CTD PMID:24015256 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP Pyocyanine results in decreased expression of FABP4 mRNA CTD PMID:31078726 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO Pyocyanine results in increased expression of GCLC mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA]
CTD PMID:24015256 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Hsf1 heat shock factor 1 increases activity ISO Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Il10 interleukin 10 increases expression EXP Pyocyanine results in increased expression of IL10 protein CTD PMID:31078726 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
JBrowse link
G Il13 interleukin 13 decreases expression EXP Pyocyanine results in decreased expression of IL13 protein CTD PMID:31078726 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
JBrowse link
G Il6 interleukin 6 increases expression EXP Pyocyanine results in increased expression of IL6 protein CTD PMID:31078726 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K1 protein CTD PMID:24015256 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases phosphorylation ISO Pyocyanine results in increased phosphorylation of MAP2K2 protein CTD PMID:24015256 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] CTD PMID:24015256 PMID:24316274 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Pyocyanine results in increased phosphorylation of MAPK3 protein
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:24015256 PMID:24316274 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
increases activity
ISO
EXP
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein]
Pyocyanine results in increased activity of NFE2L2 protein
CTD PMID:24015256 PMID:27613716 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
ISO Pyocyanine results in increased expression of NQO1 mRNA
[Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA]
CTD PMID:24015256 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP Pyocyanine results in decreased expression of PPARG mRNA CTD PMID:31078726 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] CTD PMID:28476168 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Pyocyanine results in increased expression of TNF mRNA CTD PMID:31078726 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr17:56,056,984...56,160,662
Ensembl chr17:56,056,984...56,160,662
JBrowse link
G Adgre5 adhesion G protein-coupled receptor E5 decreases expression EXP S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr 8:84,449,874...84,467,812
Ensembl chr 8:84,449,880...84,467,955
JBrowse link
G Afp alpha fetoprotein multiple interactions
decreases expression
EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA
CTD PMID:18098314 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
decreases abundance
EXP PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Alad aminolevulinate, delta-, dehydratase increases activity EXP S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634
JBrowse link
G App amyloid beta precursor protein increases secretion ISO S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G As3mt arsenite methyltransferase multiple interactions
affects binding
ISO Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:24124590 PMID:25349987 NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
JBrowse link
G Atp7b ATPase, copper transporting, beta polypeptide multiple interactions EXP ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
JBrowse link
G Bhmt2 betaine-homocysteine methyltransferase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr13:93,792,605...93,810,810
Ensembl chr13:93,792,228...93,810,810
JBrowse link
G Casp12 caspase 12 decreases expression EXP S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein
CTD PMID:17869084 PMID:18571630 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cat catalase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CCN1 protein]; S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased stability of CCN1 mRNA] CTD PMID:37682722 NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [sodium arsenite results in decreased expression of CDH2 protein] CTD PMID:37682722 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression
multiple interactions
ISO S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]
CTD PMID:15983038 PMID:16996477 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions
decreases expression
EXP
ISO
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA
CTD PMID:8878782 PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]
CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184
JBrowse link
G Dnmt3a DNA methyltransferase 3A multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 PMID:22558281 NCBI chr12:3,851,559...3,964,442
Ensembl chr12:3,856,007...3,964,443
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter] CTD PMID:35490796 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Fcgr1 Fc receptor, IgG, high affinity I decreases expression EXP S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285
JBrowse link
G Fgf15 fibroblast growth factor 15 increases abundance EXP FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690
JBrowse link
G Fgl2 fibrinogen-like protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression EXP S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases abundance EXP GCLM protein mutant form results in decreased abundance of S-Adenosylmethionine CTD PMID:38830566 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[Arsenic Trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [Arsenic Trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr12:16,720,616...16,851,395
Ensembl chr12:16,720,616...16,850,887
JBrowse link
G Gsr glutathione reductase multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
JBrowse link
G Gss glutathione synthetase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta decreases expression EXP S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions EXP [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr 8:57,774,018...57,777,552
Ensembl chr 8:57,774,018...57,777,668
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hdac9 histone deacetylase 9 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094
JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
JBrowse link
G Ifi44l interferon-induced protein 44 like decreases expression EXP S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529
JBrowse link
G Ifng interferon gamma multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Il2rg interleukin 2 receptor, gamma chain decreases expression EXP S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:100,307,991...100,311,861
Ensembl chr  X:100,307,984...100,311,861
JBrowse link
G Il36g interleukin 36G decreases expression EXP S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
CTD PMID:17080400 PMID:19822164 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Klf6 Kruppel-like transcription factor 6 decreases expression
multiple interactions
EXP S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393
JBrowse link
G Lep leptin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Ltb lymphotoxin B multiple interactions EXP S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr 8:116,429,992...116,433,633
Ensembl chr 8:116,409,681...116,434,533
JBrowse link
G Mafg v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
CTD PMID:15983038 PMID:16996477 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mat1a methionine adenosyltransferase 1A affects abundance
increases chemical synthesis
EXP MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine
CTD PMID:8373829 PMID:12060674 NCBI chr14:40,826,969...40,846,385
Ensembl chr14:40,826,992...40,846,369