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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chloroform
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Accession:CHEBI:35255 term browser browse the term
Definition:A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
Synonyms:related_synonym: 1,1,1-trichloromethane;   CHCl3;   Formula=CHCl3;   InChI=1S/CHCl3/c2-1(3)4/h1H;   InChIKey=HEDRZPFGACZZDS-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Cl;   Trichlormethan;   chloroforme;   chloroformium pro narcosi;   trichloromethane
 alt_id: CHEBI:23143;   CHEBI:34628
 xref: CAS:67-66-3;   Drug_Central:4363;   Gmelin:1837;   HMDB:HMDB0029596;   KEGG:C13827;   LINCS:LSM-37229
 xref_mesh: MESH:D002725
 xref: MetaCyc:CPD-843;   PDBeChem:MCH;   PMID:10379014;   PMID:15583552;   PMID:20051454;   PMID:21850127;   PMID:23093177;   PMID:8476536;   PMID:8625290;   Reaxys:1731042;   UM-BBD_compID:c0595;   Wikipedia:Chloroform


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chloroform term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Chloroform results in decreased expression of ABCB11 mRNA CTD PMID:17522070 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP 		Chloroform results in increased expression of ABCB1 mRNA CTD PMID:15120965 PMID:17522070 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression EXP Chloroform results in increased expression of ABCB1B mRNA CTD PMID:15120965 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Chloroform results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Chloroform results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:245,518,693...245,542,864 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Chloroform results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Chloroform results in increased expression of AKR7A3 mRNA CTD PMID:21813463 NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:156,874,086...156,885,153 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Chloroform results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Chloroform results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Chloroform results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:190,832,820...190,838,211 		JBrowse link
G Anxa2 annexin A2 increases expression EXP Chloroform results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Chloroform results in increased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Asl argininosuccinate lyase increases expression EXP Chloroform results in increased expression of ASL mRNA CTD PMID:17522070 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO
EXP 		Chloroform results in increased expression of BTG2 mRNA CTD PMID:9397189 PMID:17522070 PMID:21813463 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690 		JBrowse link
G Calu calumenin increases expression EXP Chloroform results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:58,914,421...58,941,956 		JBrowse link
G Cat catalase decreases expression EXP Chloroform results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Chloroform results in increased expression of CCL2 mRNA CTD PMID:21907259 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Chloroform results in increased expression of CCNG1 mRNA CTD PMID:17522070 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Chloroform results in increased expression of CDKN1A mRNA CTD PMID:21813463 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Chloroform results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752 		JBrowse link
G Clu clusterin increases expression EXP Chloroform results in increased expression of CLU mRNA CTD PMID:17522070 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Ctsl cathepsin L increases expression EXP Chloroform results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Chloroform results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:115,797,789...115,802,158 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
increases response to substance 		ISO CYP2E1 protein results in increased metabolism of Chloroform
CYP2E1 protein results in increased oxidation of Chloroform
CYP2E1 gene SNP results in increased susceptibility to Chloroform 		CTD PMID:1664256 PMID:15289170 PMID:18350910 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Chloroform results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:15120965 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Chloroform results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression EXP Chloroform results in decreased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Chloroform results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:216,252,605...216,267,618
Ensembl chr 1:216,252,602...216,267,615 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Chloroform results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Chloroform results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:139,592,794...139,652,290
Ensembl chr  X:139,592,604...139,652,282 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Chloroform results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Chloroform results in increased expression of FOS mRNA CTD PMID:8625290 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Chloroform results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gck glucokinase increases expression EXP Chloroform results in increased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Chloroform results in decreased expression of GJB1 mRNA CTD PMID:17522070 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:70,541,862...70,549,843 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity 		ISO
EXP 		Anethole Trithione promotes the reaction [Chloroform results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Chloroform results in increased activity of GPT protein] CTD PMID:3795300 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Chloroform results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Chloroform results in increased expression of GSR mRNA CTD PMID:15914208 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Chloroform results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Chloroform results in increased expression of HAVCR1 mRNA CTD PMID:21907259 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases activity ISO Chloroform results in decreased activity of HCN2 protein CTD PMID:22024336 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:10,620,422...10,639,457 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Chloroform results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,979,759...83,077,819
Ensembl chr 4:82,979,765...83,111,242 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Chloroform results in increased expression of HMOX1 mRNA CTD PMID:15914208 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Chloroform results in increased expression of HSPA1A mRNA CTD PMID:17522070 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Chloroform results in increased expression of ICAM1 mRNA CTD PMID:17522070 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma decreases expression ISO Chloroform results in decreased expression of IFNG protein CTD PMID:16879906 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il13 interleukin 13 increases expression ISO Chloroform results in increased expression of IL13 protein CTD PMID:16879906 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions 		ISO Chloroform results in decreased expression of IL4 protein
Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA] 		CTD PMID:16879906 PMID:21977998 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 increases expression ISO Chloroform results in increased expression of IL5 protein CTD PMID:16879906 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chloroform results in decreased activity of KCNH2 protein CTD PMID:22024336 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Krt18 keratin 18 increases expression EXP Chloroform results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:135,035,982...135,039,848
Ensembl chr10:135,035,982...135,039,848 		JBrowse link
G Krt8 keratin 8 increases expression EXP Chloroform results in increased expression of KRT8 mRNA CTD PMID:17522070 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Chloroform results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lgals3 galectin 3 increases expression EXP Chloroform results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Chloroform results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Chloroform results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:146,948,958...147,007,875 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Chloroform results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Maob monoamine oxidase B decreases expression EXP Chloroform results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Chloroform results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:201,140,661...201,367,482 		JBrowse link
G Mir100 microRNA 100 decreases expression ISO Chloroform results in decreased expression of MIR100 mRNA CTD PMID:32105654 NCBI chr 8:50,798,295...50,798,374
Ensembl chr 8:50,798,295...50,798,374 		JBrowse link
G Mir125b1 microRNA 125b-1 increases expression ISO Chloroform results in increased expression of MIR125B-1 mRNA CTD PMID:32105654 NCBI chr 8:50,850,036...50,850,122
Ensembl chr 8:50,850,036...50,850,122 		JBrowse link
G Mir132 microRNA 132 decreases expression ISO Chloroform results in decreased expression of MIR132 mRNA CTD PMID:32105654 NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,522,033...60,522,133 		JBrowse link
G Mir141 microRNA 141 increases expression ISO Chloroform results in increased expression of MIR141 mRNA CTD PMID:32105654 NCBI chr 4:159,209,525...159,209,618 JBrowse link
G Mir144 microRNA 144 decreases expression ISO Chloroform results in decreased expression of MIR144 mRNA CTD PMID:32105654 NCBI chr10:63,459,397...63,459,479
Ensembl chr10:63,459,397...63,459,479 		JBrowse link
G Mir16-2 microRNA 16-2 increases expression EXP Chloroform results in increased expression of MIR16-2 mRNA CTD PMID:17522070 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421 		JBrowse link
G Mir182 microRNA 182 increases expression ISO Chloroform results in increased expression of MIR182 mRNA CTD PMID:32105654 NCBI chr 4:59,752,246...59,752,307 JBrowse link
G Mir186 microRNA 186 increases expression ISO Chloroform results in increased expression of MIR186 mRNA CTD PMID:32105654 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:249,241,650...249,241,735 		JBrowse link
G Mir196a1 microRNA 196a-1 decreases expression ISO Chloroform results in decreased expression of MIR196A-1 mRNA CTD PMID:32105654 NCBI chr10:81,727,551...81,727,630
Ensembl chr10:81,727,551...81,727,630 		JBrowse link
G Mir204 microRNA 204 increases expression ISO Chloroform results in increased expression of MIR204 mRNA CTD PMID:32105654 NCBI chr 1:229,743,461...229,743,570
Ensembl chr 1:229,743,461...229,743,570 		JBrowse link
G Mir211 microRNA 211 increases expression ISO Chloroform results in increased expression of MIR211 mRNA CTD PMID:32105654 NCBI chr 1:127,189,328...127,189,433
Ensembl chr 1:127,189,328...127,189,433 		JBrowse link
G Mir214 microRNA 214 increases expression ISO Chloroform results in increased expression of MIR214 mRNA CTD PMID:32105654 NCBI chr13:77,121,645...77,121,752
Ensembl chr13:77,121,643...77,121,752 		JBrowse link
G Mir218-2 microRNA 218-2 increases expression ISO Chloroform results in increased expression of MIR218-2 mRNA CTD PMID:32105654 NCBI chr10:20,068,451...20,068,560
Ensembl chr10:20,572,523...20,572,632 		JBrowse link
G Mir219a1 microRNA 219a-1 increases expression ISO Chloroform results in increased expression of MIR219A-1 mRNA CTD PMID:32105654 NCBI chr20:4,831,580...4,831,689
Ensembl chr20:4,831,580...4,831,689 		JBrowse link
G Mir224 microRNA 224 decreases expression ISO Chloroform results in decreased expression of MIR224 mRNA CTD PMID:32105654 NCBI chr  X:150,065,088...150,065,169 JBrowse link
G Mir29b1 microRNA 29b-1 increases expression ISO Chloroform results in increased expression of MIR29B-1 mRNA CTD PMID:32105654 NCBI chr 4:60,618,334...60,618,414 JBrowse link
G Mir33 microRNA 33 decreases expression ISO Chloroform results in decreased expression of MIR33 mRNA CTD PMID:32105654 NCBI chr 7:115,593,952...115,594,020
Ensembl chr 7:115,593,952...115,594,020 		JBrowse link
G Mir331 microRNA 331 increases expression ISO Chloroform results in increased expression of MIR331 mRNA CTD PMID:32105654 NCBI chr 7:30,414,386...30,414,481 JBrowse link
G Mir409 microRNA 409 decreases expression ISO Chloroform results in decreased expression of MIR409 mRNA CTD PMID:32105654 NCBI chr 6:134,579,185...134,579,261 JBrowse link
G Mir410 microRNA 410 increases expression ISO Chloroform results in increased expression of MIR410 mRNA CTD PMID:32105654 NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839 		JBrowse link
G Mir429 microRNA 429 increases expression ISO Chloroform results in increased expression of MIR429 mRNA CTD PMID:32105654 NCBI chr 5:171,929,682...171,929,766 JBrowse link
G Mir451a microRNA 451a increases expression ISO Chloroform results in increased expression of MIR451A mRNA CTD PMID:32105654 NCBI chr10:63,459,569...63,459,640
Ensembl chr10:63,459,569...63,459,640 		JBrowse link
G Mir496 microRNA 496 decreases expression ISO Chloroform results in decreased expression of MIR496A mRNA CTD PMID:32105654 NCBI chr 6:128,753,644...128,753,722
Ensembl chr 6:134,575,049...134,575,127 		JBrowse link
G Mir541 microRNA 541 increases expression ISO Chloroform results in increased expression of MIR541 mRNA CTD PMID:32105654 NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:134,578,421...134,578,510 		JBrowse link
G Mir582 microRNA 582 decreases expression ISO Chloroform results in decreased expression of MIR582 mRNA CTD PMID:32105654 NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:42,661,954...42,662,034 		JBrowse link
G Mir671 microRNA 671 decreases expression ISO Chloroform results in decreased expression of MIR671 mRNA CTD PMID:32105654 NCBI chr 4:11,473,194...11,473,274 JBrowse link
G Mir98 microRNA 98 decreases expression ISO Chloroform results in decreased expression of MIR98 mRNA CTD PMID:32105654 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:24,460,648...24,460,755 		JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Chloroform results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:155,076,270...155,130,051 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation 		ISO
EXP 		Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased expression of MYC mRNA]; Chloroform inhibits the reaction [Dichloroacetic Acid results in decreased methylation of MYC gene]; Chloroform inhibits the reaction [Dichloroacetic Acid results in increased expression of MYC mRNA]; Chloroform promotes the reaction [Dichloroacetic Acid results in decreased methylation of MYC promoter]
Chloroform results in increased expression of MYC mRNA
Chloroform results in decreased methylation of MYC promoter 		CTD PMID:8625290 PMID:11099637 PMID:11532874 PMID:16014735 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Chloroform results in increased localization of and results in increased activity of NFKB1 protein CTD PMID:11306435 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbib NFKB inhibitor beta increases expression EXP Chloroform results in increased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA] CTD PMID:21977998 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Chloroform results in increased expression of ODC1 mRNA CTD PMID:17522070 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Chloroform results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Chloroform results in increased expression of PCNA protein CTD PMID:11099637 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases response to substance
affects response to substance 		ISO POR results in decreased susceptibility to Chloroform
POR protein affects the susceptibility to Chloroform 		CTD PMID:18031782 PMID:23732084 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809 		JBrowse link
G Ptma prothymosin alpha increases expression EXP Chloroform results in increased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276 		JBrowse link
G Pvr PVR cell adhesion molecule increases expression EXP Chloroform results in increased expression of PVR mRNA CTD PMID:17522070 NCBI chr 1:88,689,235...88,704,641
Ensembl chr 1:88,688,981...88,704,630 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Chloroform results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:94,433,558...94,476,219
Ensembl chr 6:94,426,346...94,476,269 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Chloroform results in increased localization of and results in increased activity of RELA protein CTD PMID:11306435 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Chloroform results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:131,700,321...131,707,392 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Chloroform results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Chloroform results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Chloroform results in decreased activity of SCN5A protein CTD PMID:22024336 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Chloroform results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Chloroform results in increased expression of SLC2A1 mRNA CTD PMID:17522070 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Snora58 small nucleolar RNA, H/ACA box 58 decreases expression ISO Chloroform results in decreased expression of MIR3068 mRNA CTD PMID:32105654 NCBI chr 6:107,080,945...107,081,020 JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Chloroform results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,573...17,192,351
Ensembl chr  X:19,842,295...19,925,734 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression EXP Chloroform results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,658,172...4,668,810 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Chloroform results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Chloroform results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Chloroform results in increased expression of TIMP1 mRNA CTD PMID:17522070 PMID:23558518 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Chloroform results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation 		EXP
ISO 		Chloroform results in increased expression of TP53 mRNA
Chloroform results in increased phosphorylation of TP53 protein 		CTD PMID:8076368 PMID:17522070 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Ttr transthyretin decreases expression EXP Chloroform results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969 		JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Chloroform results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Chloroform results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Vnn1 vanin 1 increases expression ISO Chloroform results in increased expression of VNN1 mRNA CTD PMID:21907259 NCBI chr 1:23,356,324...23,366,629
Ensembl chr 1:23,356,330...23,366,629 		JBrowse link
G Zfand5 zinc finger AN1-type containing 5 increases expression ISO Chloroform results in increased expression of ZFAND5 mRNA CTD PMID:9397189 NCBI chr 1:218,765,735...218,780,391
Ensembl chr 1:228,192,311...228,206,947 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        refrigerant 18723
          chloroform 118
            trichloromethyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  halohydrocarbon 16109
                                    haloalkane 13050
                                      chloroalkane 9468
                                        chloromethanes 7620
                                          chloroform 118
                                            trichloromethyl group 0
paths to the root