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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:buffer
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Accession:CHEBI:35225 term browser browse the term
Definition:Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
Synonyms:related_synonym: buffer compound;   buffer compounds


show annotations for term's descendants           Sort by:
ammonium acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase increases activity EXP ammonium acetate results in increased activity of ADA protein CTD PMID:19900420 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adra1a adrenoceptor alpha 1A decreases expression EXP ammonium acetate results in decreased expression of ADRA1A mRNA CTD PMID:33404927 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Ampd2 adenosine monophosphate deaminase 2 increases activity EXP ammonium acetate results in increased activity of AMPD2 protein CTD PMID:19900420 NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity EXP ammonium acetate results in increased activity of AMPD3 protein CTD PMID:19900420 NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G Asl argininosuccinate lyase increases activity EXP ammonium acetate results in increased activity of ASL protein CTD PMID:16009439 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Ass1 argininosuccinate synthase 1 increases activity EXP ammonium acetate results in increased activity of ASS1 protein CTD PMID:16009439 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression EXP ammonium acetate results in decreased expression of ATP1A1 protein CTD PMID:33404927 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP ammonium acetate results in decreased expression of ATP1A2 protein CTD PMID:33404927 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP ammonium acetate results in decreased expression of ATP1A3 protein CTD PMID:33404927 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression EXP ammonium acetate results in decreased expression of ATP2A2 protein CTD PMID:33404927 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP ammonium acetate results in decreased expression of ATP2B2 protein CTD PMID:33404927 NCBI chr 4:148,450,207...148,763,653
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 decreases expression EXP ammonium acetate results in decreased expression of ATP2B3 protein CTD PMID:33404927 NCBI chr  X:156,367,582...156,464,085
Ensembl chr  X:151,216,507...151,286,775 		JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 decreases expression EXP ammonium acetate results in decreased expression of ATP2B4 protein CTD PMID:33404927 NCBI chr13:47,708,157...47,807,389
Ensembl chr13:45,156,146...45,255,246 		JBrowse link
G Calr calreticulin increases expression
decreases expression		 EXP ammonium acetate results in increased expression of CALR protein
ammonium acetate results in decreased expression of CALR mRNA		 CTD PMID:33404927 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Cat catalase increases activity
decreases activity
multiple interactions		 EXP ammonium acetate results in increased activity of CAT protein
ammonium acetate results in decreased activity of CAT protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]		 CTD PMID:12885441 PMID:15945352 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd74 CD74 molecule increases expression EXP ammonium acetate results in increased expression of CD74 mRNA; ammonium acetate results in increased expression of CD74 protein CTD PMID:33404927 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd8a CD8 subunit alpha increases expression EXP ammonium acetate results in increased expression of CD8A mRNA CTD PMID:33404927 NCBI chr 4:104,924,116...104,928,353
Ensembl chr 4:103,365,804...103,370,040 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit increases expression EXP ammonium acetate results in increased expression of CHRNE mRNA CTD PMID:33404927 NCBI chr10:55,829,835...55,838,853
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Cldn10 claudin 10 decreases expression EXP ammonium acetate results in decreased expression of CLDN10 mRNA; ammonium acetate results in decreased expression of CLDN10 protein CTD PMID:33404927 NCBI chr15:102,269,858...102,361,589
Ensembl chr15:95,862,760...95,954,526 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression EXP ammonium acetate results in increased expression of CRHR2 mRNA CTD PMID:33404927 NCBI chr 4:85,553,163...85,596,203
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP ammonium acetate results in increased expression of GPR83 mRNA CTD PMID:33404927 NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:11,693,540...11,704,028 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP ammonium acetate results in decreased expression of GRIA4 mRNA; ammonium acetate results in decreased expression of GRIA4 protein CTD PMID:33404927 NCBI chr 8:9,845,421...10,320,021
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
decreases expression		 EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP ammonium acetate results in decreased expression of GRIN2B protein CTD PMID:20084674 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grm6 glutamate metabotropic receptor 6 increases expression EXP ammonium acetate results in increased expression of GRM6 mRNA CTD PMID:33404927 NCBI chr10:35,669,003...35,683,729
Ensembl chr10:35,167,985...35,182,717 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP ammonium acetate results in increased expression of HMOX1 protein CTD PMID:12420312 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP ammonium acetate results in increased expression of ICAM1 mRNA CTD PMID:33404927 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP [Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA] CTD PMID:36346500 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP ammonium acetate results in increased expression of IL6 mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]		 CTD PMID:36346500 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP ammonium acetate results in decreased expression of ITPR1 CTD PMID:33404927 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP ammonium acetate results in increased expression of LHB mRNA CTD PMID:33404927 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mag myelin-associated glycoprotein increases expression EXP ammonium acetate results in increased expression of MAG mRNA CTD PMID:33404927 NCBI chr 1:95,275,728...95,291,133
Ensembl chr 1:86,148,228...86,163,656 		JBrowse link
G Maoa monoamine oxidase A increases activity
multiple interactions		 EXP ammonium acetate results in increased activity of MAOA protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]		 CTD PMID:12885441 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression EXP ammonium acetate results in decreased expression of NPY1R mRNA CTD PMID:33404927 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 EXP ammonium acetate results in increased expression of PARP1 protein
Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]		 CTD PMID:15147502 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma increases expression EXP ammonium acetate results in increased expression of PPP1CC protein CTD PMID:33404927 NCBI chr12:40,043,822...40,061,301
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G RT1-A1 RT1 class Ia, locus A1 decreases expression EXP ammonium acetate results in decreased expression of RT1-A1 mRNA CTD PMID:33404927 NCBI chr20:4,907,139...4,910,798 JBrowse link
G RT1-A2 RT1 class Ia, locus A2 decreases expression EXP ammonium acetate results in decreased expression of RT1-A2 mRNA CTD PMID:33404927 NCBI chr20:4,872,720...4,876,425 JBrowse link
G RT1-CE10 RT1 class I, locus CE10 decreases expression EXP ammonium acetate results in decreased expression of RT1-CE10 mRNA CTD PMID:33404927 NCBI chr20:3,381,377...3,385,052 JBrowse link
G Slc8a2 solute carrier family 8 member A2 decreases expression EXP ammonium acetate results in decreased expression of SLC8A2 protein CTD PMID:33404927 NCBI chr 1:85,944,752...85,982,900
Ensembl chr 1:76,808,725...76,847,072 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
multiple interactions		 EXP ammonium acetate results in decreased activity of SOD2 protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]		 CTD PMID:12885441 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Xdh xanthine dehydrogenase affects activity
multiple interactions		 EXP ammonium acetate affects the activity of XDH protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]		 CTD PMID:12885441 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
ketorolac tromethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase multiple interactions EXP Ketorolac Tromethamine results in decreased localization of and results in decreased activity of AANAT protein CTD PMID:37348669 NCBI chr10:102,323,647...102,330,639
Ensembl chr10:101,827,301...101,831,801 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein] CTD PMID:37348669 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ereg epiregulin increases expression ISO Ketorolac Tromethamine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of GPX1 protein CTD PMID:37348669 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Ketorolac Tromethamine results in increased activity of GSR protein CTD PMID:37348669 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il24 interleukin 24 increases expression ISO Ketorolac Tromethamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Maoa monoamine oxidase A multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein] CTD PMID:37348669 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mtnr1a melatonin receptor 1A increases localization EXP Ketorolac Tromethamine results in increased localization of MTNR1A protein CTD PMID:37348669 NCBI chr16:53,876,964...53,896,421
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Ketorolac Tromethamine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ketorolac Tromethamine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD1 protein CTD PMID:37348669 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD2 protein CTD PMID:37348669 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
triethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO triethanolamine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:268,360,738...268,375,012
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      chemical role 19506
        buffer 54
          Good's buffer substance + 0
          Htris + 12
          ammonium acetate 42
          ammonium formate 0
          bis-tris 0
          bis-tris propane 0
          diammonium citrate 0
          diisopropanolamine 0
          dipotassium hydrogen phosphate 0
          disodium PIPES 0
          disodium tetraborate decahydrate 0
          monosodium PIPES 0
          potassium formate 0
          potassium hydrogencarbonate 0
          potassium metaphosphate 0
          sodium dimethylarsinate 0
          sodium formate 0
          triammonium citrate 0
          triethanolamine 3
          triethanolammonium + 0
          tris + 0
          tris acetate 0
          tris maleate 0
          tris phosphate 0
paths to the root