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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:buffer
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Accession:CHEBI:35225 term browser browse the term
Definition:Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
Synonyms:related_synonym: buffer compound;   buffer compounds


show annotations for term's descendants           Sort by:
ammonium acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase increases activity ISO ammonium acetate results in increased activity of ADA protein CTD PMID:19900420 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G ADRA1A adrenoceptor alpha 1A decreases expression ISO ammonium acetate results in decreased expression of ADRA1A mRNA CTD PMID:33404927 NCBI chr 8:26,748,150...26,867,379
Ensembl chr 8:26,748,150...26,867,278 		JBrowse link
G AMPD2 adenosine monophosphate deaminase 2 increases activity ISO ammonium acetate results in increased activity of AMPD2 protein CTD PMID:19900420 NCBI chr 1:109,619,837...109,632,055
Ensembl chr 1:109,616,104...109,632,051 		JBrowse link
G AMPD3 adenosine monophosphate deaminase 3 increases activity ISO ammonium acetate results in increased activity of AMPD3 protein CTD PMID:19900420 NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579 		JBrowse link
G ASL argininosuccinate lyase increases activity ISO ammonium acetate results in increased activity of ASL protein CTD PMID:16009439 NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697 		JBrowse link
G ASS1 argininosuccinate synthase 1 increases activity ISO ammonium acetate results in increased activity of ASS1 protein CTD PMID:16009439 NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression ISO ammonium acetate results in decreased expression of ATP1A1 protein CTD PMID:33404927 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO ammonium acetate results in decreased expression of ATP1A2 protein CTD PMID:33404927 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression ISO ammonium acetate results in decreased expression of ATP1A3 protein CTD PMID:33404927 NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497 		JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 decreases expression ISO ammonium acetate results in decreased expression of ATP2A2 protein CTD PMID:33404927 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 decreases expression ISO ammonium acetate results in decreased expression of ATP2B2 protein CTD PMID:33404927 NCBI chr 3:10,324,023...10,708,007
Ensembl chr 3:10,324,023...10,708,007 		JBrowse link
G ATP2B3 ATPase plasma membrane Ca2+ transporting 3 decreases expression ISO ammonium acetate results in decreased expression of ATP2B3 protein CTD PMID:33404927 NCBI chr  X:153,517,642...153,582,929
Ensembl chr  X:153,517,642...153,582,939 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 decreases expression ISO ammonium acetate results in decreased expression of ATP2B4 protein CTD PMID:33404927 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,832...203,744,081 		JBrowse link
G CALR calreticulin decreases expression
increases expression		 ISO ammonium acetate results in decreased expression of CALR mRNA
ammonium acetate results in increased expression of CALR protein		 CTD PMID:33404927 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CAT catalase increases activity
decreases activity
multiple interactions		 ISO ammonium acetate results in increased activity of CAT protein
ammonium acetate results in decreased activity of CAT protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]		 CTD PMID:12885441 PMID:15945352 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CD74 CD74 molecule increases expression ISO ammonium acetate results in increased expression of CD74 mRNA; ammonium acetate results in increased expression of CD74 protein CTD PMID:33404927 NCBI chr 5:150,401,639...150,412,910
Ensembl chr 5:150,401,637...150,412,969 		JBrowse link
G CD8A CD8 subunit alpha increases expression ISO ammonium acetate results in increased expression of CD8A mRNA CTD PMID:33404927 NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396 		JBrowse link
G CHRNE cholinergic receptor nicotinic epsilon subunit increases expression ISO ammonium acetate results in increased expression of CHRNE mRNA CTD PMID:33404927 NCBI chr17:4,897,771...4,908,677
Ensembl chr17:4,897,771...4,934,438 		JBrowse link
G CLDN10 claudin 10 decreases expression ISO ammonium acetate results in decreased expression of CLDN10 mRNA; ammonium acetate results in decreased expression of CLDN10 protein CTD PMID:33404927 NCBI chr13:95,433,755...95,579,759
Ensembl chr13:95,433,604...95,579,759 		JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 increases expression ISO ammonium acetate results in increased expression of CRHR2 mRNA CTD PMID:33404927 NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129 		JBrowse link
G GPR83 G protein-coupled receptor 83 increases expression ISO ammonium acetate results in increased expression of GPR83 mRNA CTD PMID:33404927 NCBI chr11:94,377,316...94,401,419
Ensembl chr11:94,377,316...94,401,419 		JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression ISO ammonium acetate results in decreased expression of GRIA4 mRNA; ammonium acetate results in decreased expression of GRIA4 protein CTD PMID:33404927 NCBI chr11:105,609,616...105,982,090
Ensembl chr11:105,609,535...105,982,090 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
decreases expression		 ISO Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,183,337 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B decreases expression ISO ammonium acetate results in decreased expression of GRIN2B protein CTD PMID:20084674 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G GRM6 glutamate metabotropic receptor 6 increases expression ISO ammonium acetate results in increased expression of GRM6 mRNA CTD PMID:33404927 NCBI chr 5:178,978,327...178,995,320
Ensembl chr 5:178,977,587...178,996,206 		JBrowse link
G HLA-E major histocompatibility complex, class I, E decreases expression ISO ammonium acetate results in decreased expression of RT1-A2 mRNA CTD PMID:33404927 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO ammonium acetate results in increased expression of HMOX1 protein CTD PMID:12420312 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression ISO ammonium acetate results in increased expression of ICAM1 mRNA CTD PMID:33404927 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions		 ISO ammonium acetate results in increased expression of IL1B mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]		 CTD PMID:36346500 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions		 ISO ammonium acetate results in increased expression of IL6 mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Eucalyptol inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]		 CTD PMID:36346500 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 decreases expression ISO ammonium acetate results in decreased expression of ITPR1 CTD PMID:33404927 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506 		JBrowse link
G LHB luteinizing hormone subunit beta increases expression ISO ammonium acetate results in increased expression of LHB mRNA CTD PMID:33404927 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAG myelin associated glycoprotein increases expression ISO ammonium acetate results in increased expression of MAG mRNA CTD PMID:33404927 NCBI chr19:35,292,161...35,313,807
Ensembl chr19:35,292,125...35,313,807 		JBrowse link
G MAOA monoamine oxidase A increases activity
multiple interactions		 ISO ammonium acetate results in increased activity of MAOA protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]		 CTD PMID:12885441 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G NPY1R neuropeptide Y receptor Y1 decreases expression ISO ammonium acetate results in decreased expression of NPY1R mRNA CTD PMID:33404927 NCBI chr 4:163,323,962...163,344,689
Ensembl chr 4:163,323,962...163,344,832 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases expression
multiple interactions		 ISO ammonium acetate results in increased expression of PARP1 protein
Cycloheximide inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]		 CTD PMID:15147502 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PPP1CC protein phosphatase 1 catalytic subunit gamma increases expression ISO ammonium acetate results in increased expression of PPP1CC protein CTD PMID:33404927 NCBI chr12:110,708,376...110,742,891
Ensembl chr12:110,719,680...110,742,939 		JBrowse link
G SLC8A2 solute carrier family 8 member A2 decreases expression ISO ammonium acetate results in decreased expression of SLC8A2 protein CTD PMID:33404927 NCBI chr19:47,428,017...47,471,893
Ensembl chr19:47,428,017...47,471,893 		JBrowse link
G SOD2 superoxide dismutase 2 decreases activity
multiple interactions		 ISO ammonium acetate results in decreased activity of SOD2 protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]		 CTD PMID:12885441 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G XDH xanthine dehydrogenase affects activity
multiple interactions		 ISO ammonium acetate affects the activity of XDH protein
Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]		 CTD PMID:12885441 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742 		JBrowse link
ketorolac tromethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AANAT aralkylamine N-acetyltransferase multiple interactions ISO Ketorolac Tromethamine results in decreased localization of and results in decreased activity of AANAT protein CTD PMID:37348669 NCBI chr17:76,453,351...76,470,117
Ensembl chr17:76,453,351...76,470,117 		JBrowse link
G CAT catalase increases activity
multiple interactions		 ISO Ketorolac Tromethamine results in increased activity of CAT protein
Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein]		 CTD PMID:37348669 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G EREG epiregulin increases expression EXP Ketorolac Tromethamine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749 		JBrowse link
G GPX1 glutathione peroxidase 1 decreases activity ISO Ketorolac Tromethamine results in decreased activity of GPX1 protein CTD PMID:37348669 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GSR glutathione-disulfide reductase increases activity ISO Ketorolac Tromethamine results in increased activity of GSR protein CTD PMID:37348669 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G IL24 interleukin 24 increases expression EXP Ketorolac Tromethamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G MAOA monoamine oxidase A increases activity
multiple interactions		 ISO Ketorolac Tromethamine results in increased activity of MAOA protein
Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein]		 CTD PMID:37348669 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MTNR1A melatonin receptor 1A increases localization ISO Ketorolac Tromethamine results in increased localization of MTNR1A protein CTD PMID:37348669 NCBI chr 4:186,533,655...186,555,567
Ensembl chr 4:186,526,792...186,555,567 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ketorolac Tromethamine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SLPI secretory leukocyte peptidase inhibitor increases expression EXP Ketorolac Tromethamine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr20:45,252,239...45,254,564
Ensembl chr20:45,252,239...45,254,564 		JBrowse link
G SOD1 superoxide dismutase 1 decreases activity ISO Ketorolac Tromethamine results in decreased activity of SOD1 protein CTD PMID:37348669 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 decreases activity ISO Ketorolac Tromethamine results in decreased activity of SOD2 protein CTD PMID:37348669 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
triethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP triethanolamine results in increased expression of CXCL8 mRNA CTD PMID:29594315 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G IFNG interferon gamma multiple interactions EXP [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP [triethanolamine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G KCNK18 potassium two pore domain channel subfamily K member 18 multiple interactions EXP triethanolamine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr10:117,197,489...117,210,299
Ensembl chr10:117,197,489...117,210,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26559
    role 26385
      chemical role 24392
        buffer 53
          Good's buffer substance + 0
          Htris + 12
          ammonium acetate 40
          ammonium formate 0
          bis-tris 0
          bis-tris propane 0
          diammonium citrate 0
          diisopropanolamine 0
          dipotassium hydrogen phosphate 0
          disodium PIPES 0
          disodium tetraborate decahydrate 0
          monosodium PIPES 0
          potassium formate 0
          potassium hydrogencarbonate 0
          potassium metaphosphate 0
          sodium dimethylarsinate 0
          sodium formate 0
          triammonium citrate 0
          triethanolamine 4
          triethanolammonium + 0
          tris + 0
          tris acetate 0
          tris maleate 0
          tris phosphate 0
paths to the root