CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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A1bg
alpha-1-B glycoprotein
affects expression
ISO
Mercury affects the expression of A1BG protein
CTD
PMID:22030286
NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097
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A2m
alpha-2-macroglobulin
decreases expression
ISO
Mercury results in decreased expression of A2M mRNA
CTD
PMID:17547211
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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Abca1
ATP binding cassette subfamily A member 1
affects expression
ISO
Mercury affects the expression of ABCA1 mRNA
CTD
PMID:23920476
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
[ABCB1 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; ABCB1 gene SNP affects the susceptibility to and affects the abundance of Mercury
CTD
PMID:27262785 PMID:32946573
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
Mercury results in increased expression of ABCB1B mRNA
CTD
PMID:12730625
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcc1
ATP binding cassette subfamily C member 1
increases expression multiple interactions
EXP ISO
Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein ABCC1 gene SNP affects the susceptibility to and affects the abundance of Mercury
CTD
PMID:12730625 PMID:27262785
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions affects response to substance increases export increases transport affects transport
ISO EXP
ABCC2 gene SNP affects the susceptibility to and affects the abundance of Mercury; ABCC2 protein affects the transport of [Mercury co-treated with Cysteine]; Adenosine Triphosphate affects the reaction [ABCC2 protein results in increased transport of Mercury] ABCC2 gene mutant form affects the susceptibility to Mercury ABCC2 protein results in increased export of Mercury ABCC2 protein affects the transport of Mercury EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of ABCC2 protein]; Mercury results in increased expression of and affects the localization of ABCC2 protein
CTD
PMID:21134393 PMID:23052037 PMID:23059061 PMID:24039982 PMID:25145654 PMID:27262785 PMID:32909846 More...
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
ISO
Mercury results in increased expression of ABCG1 mRNA
CTD
PMID:16823088
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg2
ATP binding cassette subfamily G member 2
increases expression
ISO
Mercury results in increased expression of ABCG2 mRNA
CTD
PMID:17547211
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
increases expression
ISO
Mercury results in increased expression of ABL1 mRNA
CTD
PMID:19937285
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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Ache
acetylcholinesterase
increases activity multiple interactions
ISO EXP
Mercury results in increased activity of ACHE protein [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein
CTD
PMID:10798623 PMID:37415728
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acp2
acid phosphatase 2, lysosomal
decreases expression
ISO
Mercury results in decreased expression of ACP2 mRNA
CTD
PMID:17547211
NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
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Acsl1
acyl-CoA synthetase long-chain family member 1
decreases expression
ISO
Mercury results in decreased expression of ACSL1 mRNA
CTD
PMID:17547211
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Actb
actin, beta
increases expression
EXP
Mercury results in increased expression of ACTB mRNA
CTD
PMID:22688007
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Adck5
aarF domain containing kinase 5
decreases expression
ISO
Mercury analog results in decreased expression of ADCK5 mRNA
CTD
PMID:25056781
NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436
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Adm
adrenomedullin
increases expression
ISO
Mercury results in increased expression of ADM mRNA
CTD
PMID:17547211
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
Mercury results in increased activity of [AHR protein binds to ARNT protein]
CTD
PMID:16093525
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1b1
aldo-keto reductase family 1 member B1
decreases expression
ISO
Mercury results in decreased expression of AKR1B1 mRNA
CTD
PMID:17547211
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr7a3
aldo-keto reductase family 7 member A3
multiple interactions
EXP
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of AKR7A3 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of AKR7A3 protein
CTD
PMID:29298499
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Akt1s1
AKT1 substrate 1
decreases expression
ISO
Mercury results in decreased expression of AKT1S1 mRNA
CTD
PMID:22008530
NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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Akt2
AKT serine/threonine kinase 2
decreases expression
ISO
Mercury results in decreased expression of AKT2 mRNA
CTD
PMID:16823088
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alad
aminolevulinate dehydratase
multiple interactions decreases activity affects abundance
ISO
[zinc chloride inhibits the reaction [Mercuric Chloride results in decreased activity of ALAD protein]] which affects the abundance of Mercury; Sodium Selenite inhibits the reaction [Mercury results in decreased activity of ALAD protein] ALAD gene polymorphism affects the abundance of Mercury
CTD
PMID:12499120 PMID:14615064 PMID:25728017
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Alb
albumin
increases export multiple interactions
ISO EXP
Mercury results in increased export of ALB protein [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; [Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of ALB protein; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of ALB protein]
CTD
PMID:30090589 PMID:37137463 PMID:37676925
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh5a1
aldehyde dehydrogenase 5 family, member A1
decreases expression
ISO
Mercury analog results in decreased expression of ALDH5A1 mRNA
CTD
PMID:25056781
NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
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Aldh6a1
aldehyde dehydrogenase 6 family, member A1
decreases expression
ISO
Mercury results in decreased expression of ALDH6A1 mRNA
CTD
PMID:17547211
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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Alg3
ALG3, alpha-1,3- mannosyltransferase
increases expression
ISO
Mercury results in increased expression of ALG3 mRNA
CTD
PMID:16823088
NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912
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Als2
alsin Rho guanine nucleotide exchange factor ALS2
increases expression
ISO
Mercury results in increased expression of ALS2 mRNA
CTD
PMID:19937285
NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737
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Ank1
ankyrin 1
decreases expression
ISO
Mercury results in decreased expression of ANK1 mRNA
CTD
PMID:19937285
NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
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Ankhd1
ankyrin repeat and KH domain containing 1
increases expression
ISO
Mercury results in increased expression of ANKHD1 mRNA
CTD
PMID:16823088
NCBI chr18:28,161,882...28,260,917
Ensembl chr18:28,162,311...28,268,024
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Anxa2
annexin A2
increases expression
ISO
Mercury results in increased expression of ANXA2 mRNA
CTD
PMID:17547211
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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Ap2a2
adaptor related protein complex 2 subunit alpha 2
decreases expression
ISO
Mercury results in decreased expression of AP2A2 mRNA
CTD
PMID:19937285
NCBI chr 1:196,652,315...196,725,609
Ensembl chr 1:196,652,337...196,725,603
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Apoa2
apolipoprotein A2
affects expression
ISO
Mercury affects the expression of APOA2 protein
CTD
PMID:22030286
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Apoe
apolipoprotein E
affects response to substance
ISO
APOE gene polymorphism affects the susceptibility to Mercury; APOE polymorphism affects the susceptibility to Mercury
CTD
PMID:12897404 PMID:23603214
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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App
amyloid beta precursor protein
multiple interactions increases secretion
ISO
Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form] Mercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion of APP protein modified form
CTD
PMID:12182891 PMID:25673500
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Aqp1
aquaporin 1
multiple interactions decreases activity
EXP ISO
Mercury inhibits the reaction [AQP1 protein results in increased transport of Water] Mercaptoethanol inhibits the reaction [Mercury results in decreased activity of AQP1 protein]
CTD
PMID:21259319 PMID:24028651
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Aqp10
aquaporin 10
decreases activity affects activity
ISO
Mercury results in decreased activity of AQP10 protein Mercury affects the activity of AQP10 protein
CTD
PMID:11573934 PMID:12084581
NCBI chr 2:175,402,609...175,407,677
Ensembl chr 2:175,403,263...175,406,815
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Aqp8
aquaporin 8
multiple interactions
EXP
Mercury affects the reaction [AQP8 protein affects the transport of Water]
CTD
PMID:18059526
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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Aqp9
aquaporin 9
multiple interactions
EXP
Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]
CTD
PMID:21259319
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Arf4
ARF GTPase 4
decreases expression
ISO
Mercury results in decreased expression of ARF4 mRNA
CTD
PMID:16823088
NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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Arg1
arginase 1
decreases activity
EXP
Mercury results in decreased activity of ARG1 protein
CTD
PMID:11916150
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Arg2
arginase 2
decreases activity
EXP
Mercury results in decreased activity of ARG2 protein
CTD
PMID:11916150
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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Arhgef28
Rho guanine nucleotide exchange factor 28
decreases expression
ISO
Mercury results in decreased expression of ARHGEF28 mRNA
CTD
PMID:19937285
NCBI chr 2:29,263,888...29,560,595
Ensembl chr 2:29,263,886...29,560,672
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Arid1a
AT-rich interaction domain 1A
increases expression
ISO
Mercury results in increased expression of ARID1A mRNA
CTD
PMID:19937285
NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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Arid4a
AT-rich interaction domain 4A
affects expression
ISO
Mercury affects the expression of ARID4A mRNA
CTD
PMID:23920476
NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
Mercury results in increased activity of [AHR protein binds to ARNT protein]
CTD
PMID:16093525
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
increases expression
EXP
Mercury results in increased expression of ATP1B3 mRNA
CTD
PMID:22688007
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 Ensembl chr 8:96,910,309...96,941,598
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Atp6v1a
ATPase H+ transporting V1 subunit A
decreases expression
ISO
Mercury results in decreased expression of ATP6V1A mRNA
CTD
PMID:16823088
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
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Atxn3
ataxin 3
decreases expression
ISO
Mercury analog results in decreased expression of ATXN3 mRNA
CTD
PMID:25056781
NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
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Atxn7l3
ataxin 7-like 3
decreases expression
ISO
Mercury analog results in decreased expression of ATXN7L3 mRNA
CTD
PMID:25056781
NCBI chr10:87,242,843...87,250,186
Ensembl chr10:87,243,587...87,250,620
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Azgp1
alpha-2-glycoprotein 1, zinc-binding
decreases expression
ISO
Mercury results in decreased expression of AZGP1 mRNA
CTD
PMID:17547211
NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091
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B2m
beta-2 microglobulin
multiple interactions
ISO
[Metals, Heavy results in increased abundance of Mercury] which results in increased secretion of B2M protein
CTD
PMID:39357351
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bad
BCL2-associated agonist of cell death
decreases expression
ISO
Mercury results in decreased expression of BAD mRNA
CTD
PMID:19937285
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bag6
BAG cochaperone 6
decreases expression
ISO
Mercury results in decreased expression of BAG6 mRNA
CTD
PMID:16823088
NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657
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Bank1
B-cell scaffold protein with ankyrin repeats 1
increases expression
ISO
Mercury results in increased expression of BANK1 mRNA
CTD
PMID:16823088
NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
EXP ISO
Mercury results in increased expression of BAX protein [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein]
CTD
PMID:21186712 PMID:29115570
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Mercury results in decreased expression of BCL2 protein
CTD
PMID:21186712
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l11
Bcl2-like 11
decreases expression
ISO
Mercury results in decreased expression of BCL2L11 mRNA
CTD
PMID:19937285
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bcor
BCL6 co-repressor
increases expression
ISO
Mercury results in increased expression of BCOR mRNA
CTD
PMID:16823088
NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613
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Bdnf
brain-derived neurotrophic factor
decreases expression affects response to substance
ISO
Mercury results in decreased expression of BDNF mRNA BDNF polymorphism affects the susceptibility to Mercury
CTD
PMID:16301096 PMID:19937285
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
ISO
Mercury results in increased expression of BHLHE40 mRNA
CTD
PMID:17547211 PMID:19937285
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Birc3
baculoviral IAP repeat-containing 3
increases expression
ISO
Mercury results in increased expression of BIRC3 mRNA
CTD
PMID:16823088
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Bmpr2
bone morphogenetic protein receptor type 2
increases expression
ISO
Mercury results in increased expression of BMPR2 mRNA
CTD
PMID:19937285
NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
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Braf
B-Raf proto-oncogene, serine/threonine kinase
increases expression
ISO
Mercury results in increased expression of BRAF mRNA
CTD
PMID:19937285
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
increases expression
ISO
Mercury results in increased expression of BUB1 mRNA
CTD
PMID:16823088
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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Bub3
BUB3 mitotic checkpoint protein
decreases expression
ISO
Mercury results in decreased expression of BUB3 mRNA
CTD
PMID:16823088
NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036
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C3
complement C3
affects expression
ISO
Mercury affects the expression of C3 protein
CTD
PMID:22030286
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C6
complement C6
affects expression
ISO
Mercury affects the expression of C6 protein
CTD
PMID:22030286
NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275
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Cadm1
cell adhesion molecule 1
decreases expression
ISO
Mercury results in decreased expression of CADM1 mRNA
CTD
PMID:19937285
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Cadm2
cell adhesion molecule 2
decreases expression
ISO
Mercury analog results in decreased expression of CADM2 mRNA
CTD
PMID:25056781
NCBI chr11:4,548,367...5,525,420
Ensembl chr11:4,555,159...5,525,400
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Calm3
calmodulin 3
decreases expression
ISO
Mercury results in decreased expression of CALM3 mRNA
CTD
PMID:16823088
NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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Capns1
calpain, small subunit 1
decreases expression
ISO
Mercury analog results in decreased expression of CAPNS1 mRNA
CTD
PMID:25056781
NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
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Capzb
capping actin protein of muscle Z-line subunit beta
increases expression
ISO
Mercury results in increased expression of CAPZB mRNA
CTD
PMID:19937285
NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
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Car1
carbonic anhydrase 1
decreases activity
ISO
Mercury results in decreased activity of CA1 protein
CTD
PMID:18237030
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
decreases activity
ISO
Mercury results in decreased activity of CA2 protein
CTD
PMID:18237030
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car3
carbonic anhydrase 3
increases expression
ISO
Mercury results in increased expression of CA3 mRNA
CTD
PMID:16823088
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Carns1
carnosine synthase 1
decreases expression
ISO
Mercury analog results in decreased expression of CARNS1 mRNA
CTD
PMID:25056781
NCBI chr 1:201,459,061...201,470,019
Ensembl chr 1:201,459,076...201,469,845
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Casp1
caspase 1
multiple interactions
ISO
CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]
CTD
PMID:28453771
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
increases activity increases expression multiple interactions
ISO EXP
Mercury results in increased activity of CASP3 protein Mercury results in increased expression of CASP3 protein [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of CASP3 protein] [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP3 protein]
CTD
PMID:16823075 PMID:21186712 PMID:29115570 PMID:37415728 PMID:37676925
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases expression multiple interactions
EXP ISO
Mercury results in increased expression of CASP9 protein [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of CASP9 protein]
CTD
PMID:21186712 PMID:29115570
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity multiple interactions
EXP
Mercury results in decreased activity of CAT protein [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Selenium affects the reaction [Mercury results in decreased activity of CAT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in decreased expression of CAT protein]
CTD
PMID:17176674 PMID:20143455 PMID:37415728 PMID:37676925
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Catsper2
cation channel, sperm associated 2
decreases expression
ISO
Mercury results in decreased expression of CATSPER2 mRNA
CTD
PMID:29549816
NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050
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Cavin2
caveolae associated protein 2
decreases expression
ISO
Mercury analog results in decreased expression of CAVIN2 mRNA
CTD
PMID:25056781
NCBI chr 9:50,302,079...50,314,096
Ensembl chr 9:50,301,206...50,314,147
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Cbx7
chromobox 7
decreases expression
ISO
Mercury analog results in decreased expression of CBX7 mRNA
CTD
PMID:25056781
NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973
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Ccl12
C-C motif chemokine ligand 12
increases expression
ISO
Mercury results in increased expression of CCL12 mRNA
CTD
PMID:30103553
NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
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Ccl3
C-C motif chemokine ligand 3
increases expression multiple interactions
EXP ISO
Mercury results in increased expression of CCL3 mRNA MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]
CTD
PMID:12730625 PMID:30103553
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl7
C-C motif chemokine ligand 7
multiple interactions
ISO
[MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA
CTD
PMID:30103553
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccnb2
cyclin B2
increases expression
ISO
Mercury results in increased expression of CCNB2 mRNA
CTD
PMID:17547211
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccr2
C-C motif chemokine receptor 2
decreases expression
ISO
Mercury results in decreased expression of CCR2 mRNA
CTD
PMID:16823088
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Cd226
CD226 molecule
increases expression
ISO
Mercury results in increased expression of CD226 mRNA
CTD
PMID:16823088
NCBI chr18:82,449,924...82,545,107
Ensembl chr18:82,450,568...82,543,051
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Cd40
CD40 molecule
increases expression
ISO
Mercury results in increased expression of CD40 mRNA
CTD
PMID:16823088
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd84
CD84 molecule
decreases expression
ISO
Mercury results in decreased expression of CD84 mRNA
CTD
PMID:16823088
NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076
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Cdh1
cadherin 1
decreases expression
ISO
Mercury results in decreased expression of CDH1 mRNA
CTD
PMID:26600472
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
increases expression
ISO
Mercury results in increased expression of CDK5R1 mRNA
CTD
PMID:16823088
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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Cdkl2
cyclin dependent kinase like 2
decreases expression
ISO
Mercury analog results in decreased expression of CDKL2 mRNA
CTD
PMID:25056781
NCBI chr14:16,027,381...16,063,257
Ensembl chr14:16,028,363...16,063,252
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Cdkn3
cyclin-dependent kinase inhibitor 3
increases expression
ISO
Mercury results in increased expression of CDKN3 mRNA
CTD
PMID:17547211
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cebpd
CCAAT/enhancer binding protein delta
decreases expression
ISO
Mercury results in decreased expression of CEBPD mRNA
CTD
PMID:19937285
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
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Cfb
complement factor B
decreases expression affects expression
ISO
Mercury results in decreased expression of CFB mRNA Mercury affects the expression of CFB protein
CTD
PMID:17547211 PMID:22030286
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Cfd
complement factor D
increases expression
ISO
Mercury results in increased expression of CFD mRNA
CTD
PMID:16823088
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
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Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
decreases expression
ISO
Mercury analog results in decreased expression of CHAC1 mRNA
CTD
PMID:25056781
NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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Chat
choline O-acetyltransferase
decreases expression
EXP
Mercury results in decreased expression of CHAT mRNA
CTD
PMID:7781173
NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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Cideb
cell death-inducing DFFA-like effector b
decreases expression
ISO
Mercury results in decreased expression of CIDEB mRNA
CTD
PMID:17547211
NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605
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Cks2
CDC28 protein kinase regulatory subunit 2
increases expression
ISO
Mercury results in increased expression of CKS2 mRNA
CTD
PMID:17547211
NCBI chr17:13,570,611...13,575,770
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Clasp2
cytoplasmic linker associated protein 2
increases expression
ISO
Mercury results in increased expression of CLASP2 mRNA
CTD
PMID:16823088
NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731
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Clgn
calmegin
decreases expression
ISO
Mercury results in decreased expression of CLGN mRNA
CTD
PMID:17547211
NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
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Clk1
CDC-like kinase 1
affects expression
ISO
Mercury affects the expression of CLK1 mRNA
CTD
PMID:16823088
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
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Clptm1
CLPTM1 regulator of GABA type A receptor forward trafficking
decreases expression increases expression
ISO
Mercury results in decreased expression of CLPTM1 mRNA Mercury results in increased expression of CLPTM1 mRNA
CTD
PMID:16823088 PMID:17547211
NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092
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Cltc
clathrin heavy chain
decreases expression
ISO
Mercury results in decreased expression of CLTC mRNA
CTD
PMID:16823088
NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
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Cmbl
carboxymethylenebutenolidase homolog
decreases expression
ISO
Mercury analog results in decreased expression of CMBL mRNA
CTD
PMID:25056781
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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Cnot3
CCR4-NOT transcription complex, subunit 3
increases expression
ISO
Mercury results in increased expression of CNOT3 mRNA
CTD
PMID:19937285
NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167
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Col26a1
collagen type XXVI alpha 1 chain
decreases methylation
ISO
Mercury results in decreased methylation of COL26A1 gene
CTD
PMID:25748564
NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556
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Col4a3
collagen type IV alpha 3 chain
increases expression
ISO
Mercury results in increased expression of COL4A3 mRNA
CTD
PMID:16823088
NCBI chr 9:83,875,849...84,004,955
Ensembl chr 9:83,875,561...84,001,895
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Comt
catechol-O-methyltransferase
affects response to substance
ISO
COMT gene polymorphism affects the susceptibility to Mercury; COMT gene SNP affects the susceptibility to Mercury
CTD
PMID:19296409 PMID:24593143
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Cp
ceruloplasmin
affects expression
ISO
Mercury affects the expression of CP protein
CTD
PMID:22030286
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Cpn2
carboxypeptidase N subunit 2
affects expression
ISO
Mercury affects the expression of CPN2 protein
CTD
PMID:22030286
NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472
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Cpox
coproporphyrinogen oxidase
affects response to substance multiple interactions decreases activity
ISO
CPOX polymorphism affects the susceptibility to Mercury; CPOX protein affects the susceptibility to Mercury; CPOX protein polymorphism affects the susceptibility to Mercury [Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins; Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III]; Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen]
CTD
PMID:16214298 PMID:16343843 PMID:19339664
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
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Cpz
carboxypeptidase Z
increases expression
ISO
Mercury results in increased expression of CPZ mRNA
CTD
PMID:16823088
NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945
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Crip1
cysteine rich protein 1
decreases expression
ISO
Mercury analog results in decreased expression of CRIP1 mRNA
CTD
PMID:25056781
NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620
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Cryaa
crystallin, alpha A
decreases expression
ISO
Mercury results in decreased expression of CRYAA mRNA
CTD
PMID:17547211
NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
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Cryab
crystallin, alpha B
multiple interactions decreases response to substance increases expression
ISO
[arsenite co-treated with Cadmium] promotes the reaction [Mercury results in increased expression of CRYAB protein]; [arsenite co-treated with Mercury] promotes the reaction [Cadmium results in increased expression of CRYAB protein]; [Mercury co-treated with Cadmium] promotes the reaction [arsenite results in increased expression of CRYAB protein] CRYAB protein results in decreased susceptibility to Mercury
CTD
PMID:15590893
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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Cryz
crystallin zeta
multiple interactions increases activity
ISO
Mercury promotes the reaction [Benzo(a)pyrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CRYZ protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CRYZ mRNA] Mercury results in increased activity of CRYZ protein
CTD
PMID:15297030
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
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Cspg5
chondroitin sulfate proteoglycan 5
increases expression
ISO
Mercury results in increased expression of CSPG5 mRNA
CTD
PMID:16823088
NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758
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Csrnp2
cysteine and serine rich nuclear protein 2
increases expression
ISO
Mercury results in increased expression of CSRNP2 mRNA
CTD
PMID:19937285
NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075
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Cst3
cystatin C
multiple interactions
ISO
[Metals, Heavy results in increased abundance of Mercury] which results in increased secretion of CST3 protein
CTD
PMID:39357351
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Ctbp1
C-terminal binding protein 1
increases expression
ISO
Mercury results in increased expression of CTBP1 mRNA
CTD
PMID:16823088
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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Ctsb
cathepsin B
increases activity
ISO
Mercury results in increased activity of CTSB protein
CTD
PMID:25237059
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cul4b
cullin 4B
decreases expression
ISO
Mercury analog results in decreased expression of CUL4B mRNA
CTD
PMID:25056781
NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688
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Cyb561
cytochrome b-561
decreases expression
ISO
Mercury results in decreased expression of CYB561 mRNA
CTD
PMID:16823088
NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases stability increases activity increases expression
ISO
[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Cycloheximide promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; pyrazolanthrone promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 inhibits the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; U 0126 promotes the reaction [Mercury results in increased expression of CYP1A1 mRNA] Mercury results in increased stability of CYP1A1 protein Mercury results in increased activity of CYP1A1 protein
CTD
PMID:15297030 PMID:16093525 PMID:18078826 PMID:22579925 PMID:23231920 PMID:36245390 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions increases activity
ISO
[Mercury co-treated with methylmercuric chloride] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A2 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] Mercury results in increased activity of CYP1A2 protein
CTD
PMID:22579925 PMID:23231920 PMID:36245390
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions increases expression
ISO
Mercury affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1B1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Mercury results in increased expression of CYP1B1 protein
CTD
PMID:22579925 PMID:23231920
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2u1
cytochrome P450, family 2, subfamily u, polypeptide 1
increases expression
ISO
Mercury results in increased expression of CYP2U1 mRNA
CTD
PMID:16823088
NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases activity
EXP
Mercury results in decreased activity of CYP7A1 protein
CTD
PMID:1175606
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dab1
DAB adaptor protein 1
increases expression
ISO
Mercury results in increased expression of DAB1 mRNA
CTD
PMID:16823088
NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
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Dcx
doublecortin
multiple interactions
ISO
[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of DCX mRNA
CTD
PMID:37914285
NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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Def8
differentially expressed in FDCP 8 homolog
decreases expression
ISO
Mercury results in decreased expression of DEF8 mRNA
CTD
PMID:22008530
NCBI chr19:51,474,783...51,495,638
Ensembl chr19:51,474,878...51,495,638
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Diras1
DIRAS family GTPase 1
decreases expression
ISO
Mercury results in decreased expression of DIRAS1 mRNA
CTD
PMID:19937285
NCBI chr 7:8,687,964...8,692,828
Ensembl chr 7:8,687,942...8,693,831
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Dnah1
dynein, axonemal, heavy chain 1
decreases expression
ISO
Mercury results in decreased expression of DNAH1 mRNA
CTD
PMID:16823088
NCBI chr16:6,455,514...6,517,103
Ensembl chr16:6,456,002...6,518,350
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Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
increases expression
EXP
Mercury results in increased expression of DNAJA2 mRNA
CTD
PMID:22688007
NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
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Dock10
dedicator of cytokinesis 10
increases expression
ISO
Mercury results in increased expression of DOCK10 mRNA
CTD
PMID:16823088
NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525
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Dpysl4
dihydropyrimidinase-like 4
increases expression
ISO
Mercury results in increased expression of DPYSL4 mRNA
CTD
PMID:16823088
NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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Drd3
dopamine receptor D3
multiple interactions
EXP
Mercury inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]
CTD
PMID:10215675
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Drd4
dopamine receptor D4
multiple interactions
EXP
Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]
CTD
PMID:10215675
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
G
Dtna
dystrobrevin, alpha
increases expression
ISO
Mercury results in increased expression of DTNA mRNA
CTD
PMID:16823088
NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
G
Eea1
early endosome antigen 1
increases expression
ISO
Mercury results in increased expression of EEA1 mRNA
CTD
PMID:16823088
NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
G
Efnb1
ephrin B1
increases expression
ISO
Mercury results in increased expression of EFNB1 mRNA
CTD
PMID:16823088
NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157
G
Eif2ak1
eukaryotic translation initiation factor 2 alpha kinase 1
decreases activity multiple interactions
ISO
Mercury results in decreased activity of EIF2AK1 protein Nitric Oxide inhibits the reaction [Mercury results in decreased activity of EIF2AK1 protein]
CTD
PMID:17689536
NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
G
Eif3f
eukaryotic translation initiation factor 3, subunit F
decreases expression
ISO
Mercury results in decreased expression of EIF3F mRNA
CTD
PMID:16823088
NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204
G
Eif4g1
eukaryotic translation initiation factor 4 gamma 1
decreases expression
ISO
Mercury analog results in decreased expression of EIF4G1 mRNA
CTD
PMID:25056781
NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
G
Elp1
elongator acetyltransferase complex subunit 1
decreases expression
ISO
Mercury results in decreased expression of ELP1 mRNA
CTD
PMID:16823088
NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
G
Emx2
empty spiracles homeobox 2
increases expression
ISO
Mercury results in increased expression of EMX2 mRNA
CTD
PMID:16823088
NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594
G
En1
engrailed homeobox 1
increases expression
ISO
Mercury results in increased expression of EN1 mRNA
CTD
PMID:16823088
NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
G
Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
increases expression
ISO
Mercury results in increased expression of ENPP1 mRNA
CTD
PMID:17547211
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
G
Epo
erythropoietin
multiple interactions
EXP
EPO protein affects the reaction [Mercury affects the localization of SLC22A8 protein]; EPO protein inhibits the reaction [Mercury results in increased expression of SLC22A19 protein]; EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of ABCC2 protein]; EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of SLC22A6 protein]; EPO protein promotes the reaction [Mercury results in increased expression of SLC22A8 protein]
CTD
PMID:32909846
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
G
Esr2
estrogen receptor 2
increases expression
ISO
Mercury results in increased expression of ESR2 mRNA
CTD
PMID:16823088
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Etfb
electron transfer flavoprotein subunit beta
increases expression
ISO
Mercury results in increased expression of ETFB mRNA
CTD
PMID:16823088
NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
G
Ets2
ETS proto-oncogene 2, transcription factor
increases expression
ISO
Mercury results in increased expression of ETS2 mRNA
CTD
PMID:17547211
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
G
Ezh1
enhancer of zeste 1 polycomb repressive complex 2 subunit
increases expression
ISO
Mercury results in increased expression of EZH1 mRNA
CTD
PMID:16823088
NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
G
F10
coagulation factor X
decreases expression
ISO
Mercury results in decreased expression of F10 mRNA
CTD
PMID:17547211
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
G
F5
coagulation factor V
decreases expression
ISO
Mercury results in decreased expression of F5 mRNA
CTD
PMID:17547211
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
G
Fabp5
fatty acid binding protein 5
increases expression
EXP
Mercury results in increased expression of FABP5 mRNA
CTD
PMID:12730625
NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
G
Fabp7
fatty acid binding protein 7
increases expression
ISO
Mercury results in increased expression of FABP7 mRNA
CTD
PMID:16823088
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
G
Fam184b
family with sequence similarity 184, member B
decreases expression
ISO
Mercury analog results in decreased expression of FAM184B mRNA
CTD
PMID:25056781
NCBI chr14:65,475,489...65,591,388
Ensembl chr14:65,475,489...65,591,388
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
Mercury inhibits the reaction [FAS protein binds to FAS protein]
CTD
PMID:16039944
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fcer1g
Fc epsilon receptor Ig
affects response to substance
ISO
FCER1G protein affects the susceptibility to Mercury
CTD
PMID:20976163
NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
G
Fcgr1a
Fc gamma receptor 1A
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]
CTD
PMID:28453771
NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
G
Fcgr3a
Fc gamma receptor 3A
decreases expression
ISO
Mercury results in decreased expression of FCGR3A mRNA
CTD
PMID:16823088
NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
G
Fcrla
Fc receptor-like A
decreases expression
ISO
Mercury results in decreased expression of FCRLA mRNA
CTD
PMID:16823088
NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762
G
Fech
ferrochelatase
decreases activity
ISO
Mercury results in decreased activity of FECH protein
CTD
PMID:2347080
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Ferd3l
Fer3-like bHLH transcription factor
decreases expression
ISO
Mercury results in decreased expression of FERD3L mRNA
CTD
PMID:19937285
NCBI chr 6:50,645,379...50,646,268
Ensembl chr 6:50,645,379...50,646,268
G
Fgf2
fibroblast growth factor 2
increases expression
ISO
Mercury results in increased expression of FGF2 mRNA
CTD
PMID:16823088
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Flnb
filamin B
increases expression
ISO
Mercury results in increased expression of FLNB mRNA
CTD
PMID:19937285
NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
G
Fn1
fibronectin 1
decreases expression
ISO
Mercury results in decreased expression of FN1 mRNA
CTD
PMID:16823088
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]
CTD
PMID:15111246
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
Mercury results in increased expression of FOSL1 mRNA
CTD
PMID:17547211
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Foxi1
forkhead box I1
decreases expression
ISO
Mercury results in decreased expression of FOXI1 mRNA
CTD
PMID:19937285
NCBI chr10:18,806,292...18,810,231
Ensembl chr10:18,806,308...18,810,231
G
Foxk1
forkhead box K1
increases expression
ISO
Mercury results in increased expression of FOXK1 mRNA
CTD
PMID:19937285
NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089
G
Frmd6
FERM domain containing 6
decreases expression
ISO
Mercury analog results in decreased expression of FRMD6 mRNA
CTD
PMID:25056781
NCBI chr 6:89,345,983...89,419,579
Ensembl chr 6:89,346,035...89,419,579
G
Furin
furin (paired basic amino acid cleaving enzyme)
decreases expression
ISO
Mercury results in decreased expression of FURIN mRNA
CTD
PMID:17547211
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
G
G6pd
glucose-6-phosphate dehydrogenase
decreases activity
ISO
Mercury results in decreased activity of G6PD protein
CTD
PMID:10798623
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
increases expression
ISO
Mercury results in increased expression of GABRA6 mRNA
CTD
PMID:16823088
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
G
Gas7
growth arrest specific 7
increases expression
ISO
Mercury results in increased expression of GAS7 mRNA
CTD
PMID:16823088
NCBI chr10:52,152,718...52,383,283
Ensembl chr10:52,152,493...52,383,276
G
Gatad2b
GATA zinc finger domain containing 2B
decreases expression
ISO
Mercury analog results in decreased expression of GATAD2B mRNA
CTD
PMID:25056781
NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression affects response to substance multiple interactions
ISO EXP
Mercury results in increased expression of GCLC mRNA GCLC gene SNP affects the susceptibility to Mercury [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GCLC protein; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]
CTD
PMID:17547211 PMID:19515364 PMID:22236634 PMID:27837179 PMID:30359721
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases expression affects abundance affects metabolic processing
ISO
Mercury results in decreased expression of GCLM mRNA GCLM gene polymorphism affects the abundance of Mercury; GCLM protein affects the abundance of Mercury GCLM polymorphism affects the metabolism of Mercury
CTD
PMID:16961004 PMID:18560528 PMID:19937285 PMID:21925580
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Ggcx
gamma-glutamyl carboxylase
decreases expression
ISO
Mercury results in decreased expression of GGCX mRNA
CTD
PMID:17547211
NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
G
Ggt1
gamma-glutamyltransferase 1
decreases expression multiple interactions
ISO EXP
Mercury results in decreased expression of GGT1 mRNA [Zinc co-treated with Copper co-treated with Manganese co-treated with Potassium Dichromate co-treated with Nickel co-treated with Cadmium co-treated with Lead co-treated with Mercury] affects the expression of GGT1 protein
CTD
PMID:19937285 PMID:30090589
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
G
Gla
galactosidase, alpha
increases expression
ISO
Mercury results in increased expression of GLA mRNA
CTD
PMID:17547211
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
G
Glra3
glycine receptor, alpha 3
increases expression
ISO
Mercury results in increased expression of GLRA3 mRNA
CTD
PMID:16823088
NCBI chr16:34,199,937...34,848,773
Ensembl chr16:34,204,811...34,848,753
G
Gmppb
GDP-mannose pyrophosphorylase B
decreases expression
ISO
Mercury analog results in decreased expression of GMPPB mRNA
CTD
PMID:25056781
NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
G
Gngt1
G protein subunit gamma transducin 1
increases expression
ISO
Mercury results in increased expression of GNGT1 mRNA
CTD
PMID:16823088
NCBI chr 4:32,006,267...32,009,252
Ensembl chr 4:32,006,267...32,009,252
G
Gnrh1
gonadotropin releasing hormone 1
increases expression
ISO
Mercury results in increased expression of GNRH1 mRNA
CTD
PMID:16823088
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
G
Golga1
golgin A1
decreases expression
ISO
Mercury analog results in decreased expression of GOLGA1 mRNA
CTD
PMID:25056781
NCBI chr 3:22,765,690...22,812,637
Ensembl chr 3:22,767,761...22,812,585
G
Golga3
golgin A3
decreases expression
ISO
Mercury analog results in decreased expression of GOLGA3 mRNA
CTD
PMID:25056781
NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509 Ensembl chr 4:46,454,870...46,500,509
G
Gorasp1
golgi reassembly stacking protein 1
decreases expression
ISO
Mercury analog results in decreased expression of GORASP1 mRNA
CTD
PMID:25056781
NCBI chr 8:119,655,267...119,667,022
Ensembl chr 8:119,655,268...119,666,972
G
Gper1
G protein-coupled estrogen receptor 1
decreases expression
ISO
Mercury results in decreased expression of GPER1 mRNA
CTD
PMID:17547211
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of GPT protein]
CTD
PMID:37676925
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx1
glutathione peroxidase 1
affects response to substance increases expression
ISO
GPX1 gene SNP affects the susceptibility to Mercury Mercury results in increased expression of GPX1 protein
CTD
PMID:16451871 PMID:22236634
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gsn
gelsolin
decreases expression affects expression
ISO
Mercury results in decreased expression of GSN mRNA Mercury affects the expression of GSN protein
CTD
PMID:17547211 PMID:22030286
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Gsr
glutathione-disulfide reductase
decreases activity multiple interactions
ISO EXP
Mercury results in decreased activity of GSR protein [Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
CTD
PMID:10798623 PMID:17176674
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gss
glutathione synthetase
affects abundance
ISO
GSS gene polymorphism affects the abundance of Mercury
CTD
PMID:21967774
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
G
Gsta1
glutathione S-transferase alpha 1
affects abundance
ISO
GSTA1 gene polymorphism affects the abundance of Mercury
CTD
PMID:19515364
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
Mercury results in increased expression of GSTA2 mRNA
CTD
PMID:12167210
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
G
Gstm1
glutathione S-transferase mu 1
affects response to substance multiple interactions affects abundance
ISO
GSTM1 gene polymorphism affects the susceptibility to Mercury; GSTM1 polymorphism affects the susceptibility to Mercury [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; [GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of GSTM1 protein GSTM1 gene polymorphism affects the abundance of Mercury
CTD
PMID:17716707 PMID:19515364 PMID:20194072 PMID:24319713 PMID:25728017 PMID:30359721 More...
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
increases expression affects abundance multiple interactions
EXP ISO
Mercury results in increased expression of GSTP1 mRNA; Mercury results in increased expression of GSTP1 protein GSTP1 gene affects the abundance of Mercury; GSTP1 gene polymorphism affects the abundance of Mercury [GSTP1 gene polymorphism co-treated with GSTM1 gene polymorphism] affects the abundance of Mercury; GCLC gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GSTP1 protein
CTD
PMID:12167210 PMID:12730625 PMID:18560528 PMID:19515364 PMID:21967774 PMID:29298499 More...
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt1
glutathione S-transferase theta 1
affects abundance multiple interactions affects response to substance
ISO
GSTT1 gene polymorphism affects the abundance of Mercury [GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury; GSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury] GSTT1 gene polymorphism affects the susceptibility to Mercury; GSTT1 polymorphism affects the susceptibility to Mercury
CTD
PMID:17716707 PMID:19515364 PMID:20194072 PMID:21967774 PMID:24319713
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Gtpbp8
GTP binding protein 8
decreases expression
ISO
Mercury analog results in decreased expression of GTPBP8 mRNA
CTD
PMID:25056781
NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635
G
Gxylt2
glucoside xylosyltransferase 2
decreases expression
ISO
Mercury analog results in decreased expression of GXYLT2 mRNA
CTD
PMID:25056781
NCBI chr 4:133,347,230...133,449,708
Ensembl chr 4:133,347,499...133,449,454
G
Habp4
hyaluronan binding protein 4
increases expression
ISO
Mercury results in increased expression of HABP4 mRNA
CTD
PMID:16823088
NCBI chr17:934,931...957,604
Ensembl chr17:935,654...957,565
G
Hamp
hepcidin antimicrobial peptide
multiple interactions
ISO
[HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury
CTD
PMID:25772431
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Havcr1
hepatitis A virus cellular receptor 1
increases expression
EXP
Mercury results in increased expression of HAVCR1 mRNA; Mercury results in increased expression of HAVCR1 protein
CTD
PMID:17934191 PMID:25145654
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
G
Heph
hephaestin
increases expression
ISO
Mercury results in increased expression of HEPH mRNA
CTD
PMID:16823088
NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980
G
Hif3a
hypoxia inducible factor 3 subunit alpha
decreases expression
ISO
Mercury results in decreased expression of HIF3A mRNA
CTD
PMID:19937285
NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
G
Hint3
histidine triad nucleotide binding protein 3
decreases expression
ISO
Mercury analog results in decreased expression of HINT3 mRNA
CTD
PMID:25056781
NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721
G
Hist1h2ah
histone cluster 1 H2A family member H
increases expression
ISO
Mercury results in increased expression of H2AC11 mRNA
CTD
PMID:16823088
NCBI chr17:41,384,521...41,385,018
G
Hmgn2
high mobility group nucleosomal binding domain 2
increases expression
ISO
Mercury results in increased expression of HMGN2 mRNA
CTD
PMID:17547211
NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521 Ensembl chr16:146,192,126...146,195,521
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO EXP
Acetylcysteine inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter] [Benzo(a)pyrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [beta-Naphthoflavone co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Mercury co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 protein; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Mercury] results in increased expression of HMOX1 mRNA; Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HMOX1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HMOX1 mRNA]; Mercury results in increased expression of and results in increased activity of HMOX1 protein; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Mercury results in increased expression of HMOX mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Mercury results in increased expression of HMOX1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of HMOX1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of HMOX1 mRNA] [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]
CTD
PMID:12730625 PMID:15297030 PMID:16093525 PMID:17244614 PMID:17547211 PMID:18078826 PMID:22579925 PMID:23231920 PMID:26600472 PMID:27837179 PMID:36245390 More...
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnf1a
HNF1 homeobox A
increases expression
ISO
Mercury results in increased expression of HNF1A mRNA
CTD
PMID:16823088
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
increases expression
ISO
Mercury results in increased expression of HNRNPH3 mRNA
CTD
PMID:16823088
NCBI chr20:25,616,400...25,625,814
Ensembl chr20:25,614,733...25,625,750
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Hoxb4
homeo box B4
increases expression
ISO
Mercury results in increased expression of HOXB4 mRNA
CTD
PMID:19937285
NCBI chr10:81,284,552...81,287,134
Ensembl chr10:81,284,552...81,287,128
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Hoxb6
homeo box B6
increases expression
ISO
Mercury results in increased expression of HOXB6 mRNA
CTD
PMID:16823088
NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449
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Hpx
hemopexin
affects expression
ISO
Mercury affects the expression of HPX protein
CTD
PMID:22030286
NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328
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Hras
HRas proto-oncogene, GTPase
multiple interactions
EXP
Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]
CTD
PMID:15111246
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Hs1bp3
HCLS1 binding protein 3
decreases expression
ISO
Mercury results in decreased expression of HS1BP3 mRNA
CTD
PMID:16823088
NCBI chr 6:31,192,568...31,222,835
Ensembl chr 6:31,192,568...31,222,835
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Hsf1
heat shock transcription factor 1
multiple interactions increases activity
ISO
Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter]; Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] Mercury results in increased activity of HSF1 protein
CTD
PMID:17244614
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hsf2
heat shock transcription factor 2
decreases expression
ISO
Mercury results in decreased expression of HSF2 mRNA
CTD
PMID:22008530
NCBI chr20:36,819,864...36,847,490
Ensembl chr20:36,819,864...36,850,174
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
ISO
Mercury results in increased expression of HSP90AA1 mRNA
CTD
PMID:16823088
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions increases expression
ISO
Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] Mercury results in increased expression of HSPA1A mRNA
CTD
PMID:17244614
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1b
heat shock protein family A (Hsp70) member 1B
affects response to substance
ISO
HSPA1B gene polymorphism affects the susceptibility to Mercury
CTD
PMID:23330093
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Hspa1l
heat shock protein family A (Hsp70) member 1 like
affects response to substance
ISO
HSPA1L gene polymorphism affects the susceptibility to Mercury
CTD
PMID:23330093
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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Hspa5
heat shock protein family A (Hsp70) member 5
affects expression multiple interactions
EXP
Mercury affects the expression of HSPA5 mRNA Mercury promotes the reaction [HSPA5 protein binds to FOS enhancer]; Mercury promotes the reaction [HSPA5 protein binds to HRAS enhancer]; Mercury results in increased expression of and results in increased activity of HSPA5 protein
CTD
PMID:15111246
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Mercury results in increased expression of HSPD1 mRNA
CTD
PMID:12730625
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Htr7
5-hydroxytryptamine receptor 7
increases expression
ISO
Mercury results in increased expression of HTR7 mRNA
CTD
PMID:16823088
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
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Ifi44
interferon-induced protein 44
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFI44 mRNA
CTD
PMID:28453771
NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
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Ifng
interferon gamma
affects expression decreases secretion increases expression multiple interactions
ISO
Mercury affects the expression of IFNG mRNA; Mercury affects the expression of IFNG protein Mercury results in decreased secretion of IFNG protein Mercury results in increased expression of IFNG protein Mercury results in increased expression of IFNG mRNA [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG protein; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IFNG mRNA]
CTD
PMID:12928768 PMID:15910788 PMID:20176347 PMID:25237059 PMID:28453771
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
affects response to substance
ISO
IFNGR1 affects the susceptibility to Mercury
CTD
PMID:22578563
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Ifrd1
interferon-related developmental regulator 1
decreases expression
ISO
Mercury results in decreased expression of IFRD1 mRNA
CTD
PMID:17547211
NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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Igf1
insulin-like growth factor 1
multiple interactions
ISO
Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]
CTD
PMID:14745455
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Il10
interleukin 10
increases expression
ISO
Mercury results in increased expression of IL10 mRNA
CTD
PMID:16045731
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il13
interleukin 13
increases expression
ISO
Mercury results in increased expression of IL13 mRNA
CTD
PMID:37137463
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il17rb
interleukin 17 receptor B
decreases expression
ISO
Mercury results in decreased expression of IL17RB mRNA
CTD
PMID:17547211
NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
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Il1b
interleukin 1 beta
increases expression multiple interactions
ISO
Mercury results in increased expression of IL1B protein Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] Mercury results in increased expression of IL1B mRNA; Mercury results in increased expression of IL1B protein [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL1B mRNA; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of IL1B mRNA]
CTD
PMID:20176347 PMID:20600710 PMID:25237059 PMID:28453771 PMID:37137463
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
increases expression
EXP
Mercury results in increased expression of IL2 mRNA
CTD
PMID:12730625
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il33
interleukin 33
decreases expression
ISO
Mercury analog results in decreased expression of IL33 mRNA
CTD
PMID:25056781
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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Il3ra
interleukin 3 receptor subunit alpha
decreases expression
ISO
Mercury results in decreased expression of IL3RA mRNA
CTD
PMID:16823088
NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484
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Il4
interleukin 4
decreases secretion multiple interactions
ISO
Mercury results in decreased secretion of IL4 protein [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]
CTD
PMID:15910788 PMID:28453771
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
increases expression multiple interactions
ISO EXP
Mercury results in increased expression of IL6 protein [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL6 mRNA; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of FCGR1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IFNG mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; Salicylic Acid inhibits the reaction [Mercury results in increased expression of IL6] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of IL6 protein]
CTD
PMID:18393961 PMID:23742082 PMID:28453771 PMID:37415728 PMID:37676925
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Impg1
interphotoreceptor matrix proteoglycan 1
increases expression
ISO
Mercury results in increased expression of IMPG1 mRNA
CTD
PMID:16823088
NCBI chr 8:81,243,624...81,389,722
Ensembl chr 8:81,243,624...81,389,722
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Ins1
insulin 1
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] inhibits the reaction [Glucose results in increased secretion of INS1 protein]
CTD
PMID:33038468
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Irf1
interferon regulatory factor 1
affects response to substance multiple interactions
ISO
IRF1 affects the susceptibility to Mercury [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF1 mRNA]
CTD
PMID:22578563 PMID:28453771
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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Irf8
interferon regulatory factor 8
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]
CTD
PMID:28453771
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
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Irs1
insulin receptor substrate 1
multiple interactions
ISO
[Cadmium co-treated with Mercury] results in increased phosphorylation of IRS1 protein
CTD
PMID:30629257
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Isg15
ISG15 ubiquitin-like modifier
decreases expression
ISO
Mercury analog results in decreased expression of ISG15 mRNA
CTD
PMID:25056781
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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Itgb1
integrin subunit beta 1
increases activity
EXP
Mercury results in increased activity of ITGB1 protein
CTD
PMID:10820171
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itgb3bp
integrin subunit beta 3 binding protein
increases expression
ISO
Mercury results in increased expression of ITGB3BP mRNA
CTD
PMID:17547211
NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
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Itih1
inter-alpha trypsin inhibitor, heavy chain 1
affects expression
ISO
Mercury affects the expression of ITIH1 protein
CTD
PMID:22030286
NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
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Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
ISO
Mercury results in decreased expression of ITIH3 mRNA
CTD
PMID:17547211
NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
affects expression
ISO
Mercury affects the expression of ITIH4 protein
CTD
PMID:22030286
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
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Ivns1abp
influenza virus NS1A binding protein
decreases expression
ISO
Mercury results in decreased expression of IVNS1ABP mRNA
CTD
PMID:16823088
NCBI chr13:63,427,040...63,446,701
Ensembl chr13:63,427,041...63,446,701
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Jak2
Janus kinase 2
affects expression
ISO
Mercury affects the expression of JAK2 mRNA
CTD
PMID:23920476
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression multiple interactions
EXP ISO
Mercury results in decreased expression of JUN mRNA [Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of JUN protein
CTD
PMID:12730625 PMID:28035397
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kcnh2
potassium voltage-gated channel subfamily H member 2
increases expression
ISO
Mercury results in increased expression of KCNH2 mRNA
CTD
PMID:16823088
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Kdelr2
KDEL endoplasmic reticulum protein retention receptor 2
decreases expression
ISO
Mercury analog results in decreased expression of KDELR2 mRNA
CTD
PMID:25056781
NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153
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Klf12
KLF transcription factor 12
decreases expression
ISO
Mercury results in decreased expression of KLF12 mRNA
CTD
PMID:19937285
NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056
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Klf2
KLF transcription factor 2
decreases expression
ISO
Mercury results in decreased expression of KLF2 mRNA
CTD
PMID:19937285
NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944
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Kmt2b
lysine methyltransferase 2B
increases expression
ISO
Mercury results in increased expression of KMT2B mRNA
CTD
PMID:16823088
NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326
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Krt1
keratin 1
increases expression
ISO
Mercury results in increased expression of KRT1 mRNA
CTD
PMID:19937285
NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
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Lamc1
laminin subunit gamma 1
decreases expression
ISO
Mercury analog results in decreased expression of LAMC1 mRNA
CTD
PMID:25056781
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
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Lancl1
LanC like glutathione S-transferase 1
decreases expression
ISO
Mercury results in decreased expression of LANCL1 mRNA
CTD
PMID:16823088
NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:68,518,574...68,548,628
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Lancl2
LanC like glutathione S-transferase 2
decreases expression
ISO
Mercury results in decreased expression of LANCL2 mRNA
CTD
PMID:19937285
NCBI chr 4:87,441,821...87,483,707
Ensembl chr 4:87,441,823...87,482,800
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Lcn2
lipocalin 2
increases expression
EXP
Mercury results in increased expression of LCN2 mRNA
CTD
PMID:25145654
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Leng9
leukocyte receptor cluster member 9
decreases expression
ISO
Mercury analog results in decreased expression of LENG9 mRNA
CTD
PMID:25056781
NCBI chr 1:70,039,099...70,041,559
Ensembl chr 1:70,035,791...70,044,509
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Lepr
leptin receptor
decreases expression
ISO
Mercury results in decreased expression of LEPR mRNA
CTD
PMID:16823088
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Limd1
LIM domain containing 1
decreases expression
ISO
Mercury analog results in decreased expression of LIMD1 mRNA
CTD
PMID:25056781
NCBI chr 8:123,121,363...123,168,476
Ensembl chr 8:123,122,460...123,167,714
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Lims2
LIM zinc finger domain containing 2
decreases expression
ISO
Mercury analog results in decreased expression of LIMS2 mRNA
CTD
PMID:25056781
NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137
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Lipa
lipase A, lysosomal acid type
decreases expression
ISO
Mercury results in decreased expression of LIPA mRNA
CTD
PMID:17547211
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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Lmbr1
limb development membrane protein 1
decreases expression
ISO
Mercury analog results in decreased expression of LMBR1 mRNA
CTD
PMID:25056781
NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368
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Lmna
lamin A/C
decreases expression
ISO
Mercury results in decreased expression of LMNA mRNA
CTD
PMID:16823088
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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Lrrfip1
LRR binding FLII interacting protein 1
increases expression
ISO
Mercury results in increased expression of LRRFIP1 mRNA
CTD
PMID:16823088
NCBI chr 9:91,592,032...91,720,250
Ensembl chr 9:91,643,197...91,720,250
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Lsm5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
decreases expression
ISO
Mercury analog results in decreased expression of LSM5 mRNA
CTD
PMID:25056781
NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165 Ensembl chr 4:104,652,477...104,654,165
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Ltf
lactotransferrin
increases expression
ISO
Mercury results in increased expression of LTF protein
CTD
PMID:37137463
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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Lyn
LYN proto-oncogene, Src family tyrosine kinase
multiple interactions
ISO
Mercury results in increased phosphorylation of and results in increased activity of LYN protein
CTD
PMID:24440445
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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Lzts2
leucine zipper tumor suppressor 2
decreases expression
ISO
Mercury analog results in decreased expression of LZTS2 mRNA
CTD
PMID:25056781
NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
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Macf1
microtubule-actin crosslinking factor 1
increases expression
ISO
Mercury results in increased expression of MACF1 mRNA
CTD
PMID:16823088
NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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Maff
MAF bZIP transcription factor F
increases expression
ISO
Mercury results in increased expression of MAFF mRNA
CTD
PMID:19937285
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Mageb1
MAGE family member B1
increases expression
ISO
Mercury results in increased expression of MAGEB4 mRNA
CTD
PMID:16823088
NCBI chr X:50,915,789...50,921,863
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Man1b1
mannosidase, alpha, class 1B, member 1
affects expression
ISO
Mercury affects the expression of MAN1B1 mRNA
CTD
PMID:23920476
NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006
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Map2
microtubule-associated protein 2
multiple interactions
ISO
[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of MAP2 mRNA
CTD
PMID:37914285
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Map2k2
mitogen activated protein kinase kinase 2
increases expression
ISO
Mercury results in increased expression of MAP2K2 mRNA
CTD
PMID:16823088
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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Map9
microtubule-associated protein 9
increases expression
ISO
Mercury results in increased expression of MAP9 mRNA
CTD
PMID:19937285
NCBI chr 2:167,708,661...167,743,927
Ensembl chr 2:167,708,765...167,740,736
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Mercury results in increased phosphorylation of MAPK1 protein
CTD
PMID:21994240
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Mercury results in increased phosphorylation of MAPK3 protein
CTD
PMID:21994240
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mcm2
minichromosome maintenance complex component 2
increases expression
ISO
Mercury results in increased expression of MCM2 mRNA
CTD
PMID:17547211
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Med16
mediator complex subunit 16
increases expression
ISO
Mercury results in increased expression of MED16 mRNA
CTD
PMID:16823088
NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
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Meox2
mesenchyme homeobox 2
increases expression
ISO
Mercury results in increased expression of MEOX2 mRNA
CTD
PMID:16823088
NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
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Mfap5
microfibril associated protein 5
increases expression
ISO
Mercury results in increased expression of MFAP5 mRNA
CTD
PMID:16823088
NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458
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Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
Mercury results in decreased expression of MGAT2 mRNA
CTD
PMID:17547211
NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
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Mgat5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
increases expression
EXP
Mercury results in increased expression of MGAT5 mRNA
CTD
PMID:22688007
NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513
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Mir10a
microRNA 10a
decreases expression
ISO
Mercury results in decreased expression of MIR10A mRNA
CTD
PMID:26252056
NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280
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Mir151
microRNA 151
decreases expression
ISO
Mercury results in decreased expression of MIR151A mRNA
CTD
PMID:26252056
NCBI chr 7:105,172,377...105,172,473
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Mir190b
microRNA 190b
decreases expression
ISO
Mercury results in decreased expression of MIR190B mRNA
CTD
PMID:26252056
NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877
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Mir193b
microRNA 193b
decreases expression
ISO
Mercury results in decreased expression of MIR193B mRNA
CTD
PMID:26252056
NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
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Mir423
microRNA 423
decreases expression
ISO
Mercury results in decreased expression of MIR423 mRNA
CTD
PMID:26252056
NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
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Mir96
microRNA 96
decreases expression
ISO
Mercury results in decreased expression of MIR96 mRNA
CTD
PMID:26252056
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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Mirlet7b
microRNA let-7b
decreases expression
ISO
Mercury results in decreased expression of MIRLET7B mRNA
CTD
PMID:26252056
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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Mirlet7c1
microRNA let-7c-1
decreases expression
ISO
Mercury results in decreased expression of MIRLET7C mRNA
CTD
PMID:26252056
NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265
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Mirlet7d
microRNA let-7d
decreases expression
ISO
Mercury results in decreased expression of MIRLET7D mRNA
CTD
PMID:26252056
NCBI chr17:16,115,893...16,115,990
Ensembl chr17:16,115,893...16,115,990
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Mirlet7g
microRNA let-7g
decreases expression
ISO
Mercury results in decreased expression of MIRLET7G mRNA
CTD
PMID:26252056
NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388
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Mirlet7i
microRNA let-7i
decreases expression
ISO
Mercury results in decreased expression of MIRLET7I mRNA
CTD
PMID:26252056
NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571
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Mme
membrane metallo-endopeptidase
increases expression multiple interactions
ISO
Mercury results in increased expression of MME protein Mercury affects the folding of and results in decreased activity of MME protein
CTD
PMID:25673500
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Mmp2
matrix metallopeptidase 2
multiple interactions
ISO
Mercury affects the reaction [MMP2 promoter polymorphism results in increased expression of MMP2 protein]
CTD
PMID:21794897
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
affects response to substance
ISO
MMP9 promoter polymorphism affects the susceptibility to Mercury
CTD
PMID:20554312
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Morf4l2
mortality factor 4 like 2
decreases expression
ISO
Mercury results in decreased expression of MORF4L2 mRNA
CTD
PMID:16823088
NCBI chr X:100,082,562...100,093,658
Ensembl chr X:100,082,404...100,093,728
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Mpo
myeloperoxidase
decreases activity
ISO
Mercury results in decreased activity of MPO protein
CTD
PMID:15557676
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mrps23
mitochondrial ribosomal protein S23
decreases expression
ISO
Mercury analog results in decreased expression of MRPS23 mRNA
CTD
PMID:25056781
NCBI chr10:72,999,033...73,006,791
Ensembl chr10:72,998,497...73,006,264
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Msh6
mutS homolog 6
increases expression
ISO
Mercury results in increased expression of MSH6 mRNA
CTD
PMID:19937285
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
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Msl3
MSL complex subunit 3
decreases expression
ISO
Mercury analog results in decreased expression of MSL3 mRNA
CTD
PMID:25056781
NCBI chr X:25,638,029...25,655,698
Ensembl chr X:25,637,804...25,655,697
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Msr1
macrophage scavenger receptor 1
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of MSR1 mRNA
CTD
PMID:28453771
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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Mt1
metallothionein 1
increases expression affects abundance multiple interactions affects binding increases response to substance
EXP ISO
Mercury results in increased expression of MT1 mRNA; Mercury results in increased expression of MT1 protein; Mercury results in increased expression of MT1A mRNA MT1A gene polymorphism affects the abundance of Mercury; MT1A gene SNP affects the abundance of Mercury [MT1 co-treated with MT2] affects the susceptibility to Mercury Mercury binds to MT1 protein MT1 gene mutant form results in increased susceptibility to Mercury
CTD
PMID:8917669 PMID:9462895 PMID:9587011 PMID:12167210 PMID:12730625 PMID:15138662 PMID:15603537 PMID:15782327 PMID:17018868 PMID:19515364 PMID:21628964 PMID:22008530 PMID:22233731 More...
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mt1-ps3
metallothionein 1, pseudogene 3
affects response to substance
ISO
MT1E gene SNP affects the susceptibility to Mercury
CTD
PMID:22236634
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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Mt2A
metallothionein 2A
affects abundance affects binding increases expression increases response to substance multiple interactions affects response to substance
ISO EXP
MT2A gene SNP affects the abundance of Mercury Mercury binds to MT2 protein Mercury results in increased expression of MT2 mRNA; Mercury results in increased expression of MT2 protein MT2 gene mutant form results in increased susceptibility to Mercury [MT1 co-treated with MT2] affects the susceptibility to Mercury; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA [MT1M gene polymorphism co-treated with MT2A gene polymorphism] affects the susceptibility to Mercury MT2A gene polymorphism affects the susceptibility to Mercury Mercury results in increased expression of MT2A mRNA
CTD
PMID:2771874 PMID:8917669 PMID:9462895 PMID:9587011 PMID:15138662 PMID:15603537 PMID:15782327 PMID:17018868 PMID:21628964 PMID:22008530 PMID:22233731 PMID:23827881 PMID:30103553 More...
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mt3
metallothionein 3
affects binding increases expression multiple interactions affects response to substance
ISO EXP
Mercury binds to MT3 protein Mercury results in increased expression of MT3 mRNA; Mercury results in increased expression of MT3 protein [MT3 protein affects the susceptibility to Mercury] which affects the expression of CCL7 mRNA; [MT3 protein affects the susceptibility to Mercury] which affects the expression of MT2 mRNA; MT3 protein affects the reaction [Mercury results in increased expression of CCL3 mRNA]
CTD
PMID:8917669 PMID:9587011 PMID:15138662 PMID:15782327 PMID:17018868 PMID:30103553 More...
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Mt4
metallothionein 4
affects abundance
ISO
MT4 gene polymorphism affects the abundance of Mercury
CTD
PMID:19515364
NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909
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Mtf1
metal-regulatory transcription factor 1
increases expression
ISO
Mercury results in increased expression of MTF1 mRNA
CTD
PMID:16823088
NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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Mtmr11
myotubularin related protein 11
decreases expression
ISO
Mercury results in decreased expression of MTMR11 mRNA
CTD
PMID:16823088
NCBI chr 2:183,721,983...183,732,148
Ensembl chr 2:183,723,530...183,732,148
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Mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
multiple interactions
ISO
Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Mercury inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]
CTD
PMID:14745455 PMID:26989453
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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Mtrf1
mitochondrial translation release factor 1
decreases expression
ISO
Mercury results in decreased expression of MTRF1 mRNA
CTD
PMID:19937285
NCBI chr15:54,776,885...54,804,699
Ensembl chr15:54,776,937...54,804,704
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Muc2
mucin 2, oligomeric mucus/gel-forming
increases expression
ISO
Mercury results in increased expression of MUC2 mRNA
CTD
PMID:37137463
NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756
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Mvb12b
multivesicular body subunit 12B
increases expression
ISO
Mercury results in increased expression of MVB12B mRNA
CTD
PMID:16823088
NCBI chr 3:17,034,002...17,192,658
Ensembl chr 3:17,034,003...17,193,202
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression affects expression
ISO
Mercury results in decreased expression of MYC mRNA Mercury affects the expression of MYC mRNA
CTD
PMID:12928768 PMID:16823088
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Myo1b
myosin Ib
increases expression decreases expression
ISO
Mercury results in increased expression of MYO1B mRNA Mercury analog results in decreased expression of MYO1B mRNA
CTD
PMID:16823088 PMID:25056781
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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Mzf1
myeloid zinc finger 1
decreases expression
ISO
Mercury analog results in decreased expression of MZF1 mRNA
CTD
PMID:25056781
NCBI chr 1:73,670,522...73,682,885
Ensembl chr 1:73,670,541...73,681,635
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Nap1l1
nucleosome assembly protein 1-like 1
increases expression
ISO
Mercury results in increased expression of NAP1L1 mRNA
CTD
PMID:16823088
NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
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Nat1
N-acetyltransferase 1
multiple interactions
ISO
Mercury binds to and results in decreased activity of NAT1 protein
CTD
PMID:20591428
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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Nav3
neuron navigator 3
increases expression
ISO
Mercury results in increased expression of NAV3 mRNA
CTD
PMID:16823088
NCBI chr 7:45,052,206...45,840,471
Ensembl chr 7:45,054,296...45,840,698
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Ncapd3
non-SMC condensin II complex, subunit D3
increases expression decreases expression
ISO
Mercury results in increased expression of NCAPD3 mRNA Mercury analog results in decreased expression of NCAPD3 mRNA
CTD
PMID:19937285 PMID:25056781
NCBI chr 8:25,437,067...25,506,375
Ensembl chr 8:25,437,123...25,506,373
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Ncoa3
nuclear receptor coactivator 3
increases expression
ISO
Mercury results in increased expression of NCOA3 mRNA
CTD
PMID:16823088
NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
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Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
decreases expression
ISO
Mercury results in decreased expression of NDUFS2 mRNA
CTD
PMID:16823088
NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
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Nfatc4
nuclear factor of activated T-cells 4
increases expression
ISO
Mercury results in increased expression of NFATC4 mRNA
CTD
PMID:19937285
NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions increases expression increases activity
ISO EXP
NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA] Mercury results in increased expression of NFE2L2 mRNA Mercury results in increased activity of NFE2L2 promoter [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]
CTD
PMID:16243960 PMID:21643505 PMID:27837179 PMID:30359721 PMID:37415728
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO EXP
Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of NFKB1 protein] [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein; Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]
CTD
PMID:11437639 PMID:15282405 PMID:37415728
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:11437639
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngf
nerve growth factor
increases expression decreases expression
ISO EXP
Mercury results in increased expression of NGF mRNA Mercury results in decreased expression of NGF mRNA
CTD
PMID:7781173 PMID:16823088
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ngfr
nerve growth factor receptor
decreases expression
EXP
Mercury results in decreased expression of NGFR mRNA
CTD
PMID:7781173
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nherf2
NHERF family PDZ scaffold protein 2
increases expression
ISO
Mercury results in increased expression of NHERF2 mRNA
CTD
PMID:16823088
NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049
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Nlrp1a
NLR family, pyrin domain containing 1A
decreases expression
ISO
Mercury results in decreased expression of NLRP1 mRNA
CTD
PMID:19937285
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180
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Nlrp3
NLR family, pyrin domain containing 3
increases expression multiple interactions
ISO
Mercury results in increased expression of NLRP3 mRNA N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of NLRP3 mRNA]
CTD
PMID:25237059
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nmt2
N-myristoyltransferase 2
increases expression
ISO
Mercury results in increased expression of NMT2 mRNA
CTD
PMID:16823088
NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080
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Nod1
nucleotide-binding oligomerization domain containing 1
decreases expression
ISO
Mercury results in decreased expression of NOD1 mRNA
CTD
PMID:19937285
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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Nox4
NADPH oxidase 4
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NOX4 protein
CTD
PMID:30359721
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases activity increases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Cycloheximide inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 protein]; Mercury results in increased expression of and results in increased activity of NQO1 protein; NFE2L2 protein affects the reaction [Mercury results in increased expression of NQO1 mRNA]; prolinedithiocarbamate promotes the reaction [Mercury results in increased expression of NQO1 protein]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; pyrazolanthrone inhibits the reaction [Mercury results in increased expression of NQO1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Mercury results in increased expression of NQO1 protein]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; U 0126 promotes the reaction [Mercury results in increased expression of NQO1 protein] Mercury results in increased activity of NQO1 protein Mercury results in increased expression of NQO1 mRNA; Mercury results in increased expression of NQO1 protein Acetylcysteine inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]
CTD
PMID:16243960 PMID:18752316 PMID:22579925 PMID:26600472
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
EXP
Mercury results in decreased expression of NR4A1 mRNA
CTD
PMID:12730625
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nsrp1
nuclear speckle splicing regulatory protein 1
decreases expression
ISO
Mercury analog results in decreased expression of NSRP1 mRNA
CTD
PMID:25056781
NCBI chr10:61,880,807...61,914,471
Ensembl chr10:61,880,825...61,914,471
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Ntrk3
neurotrophic receptor tyrosine kinase 3
increases expression
ISO
Mercury results in increased expression of NTRK3 mRNA
CTD
PMID:19937285
NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
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Nup107
nucleoporin 107
increases expression
ISO
Mercury results in increased expression of NUP107 mRNA
CTD
PMID:17547211
NCBI chr 7:53,353,740...53,398,345
Ensembl chr 7:53,353,743...53,398,370
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Ocln
occludin
decreases expression
ISO
Mercury results in decreased expression of OCLN mRNA
CTD
PMID:37137463
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Ogg1
8-oxoguanine DNA glycosylase
decreases expression
ISO
Mercury results in decreased expression of OGG1 mRNA
CTD
PMID:22641096
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
G
Oprd1
opioid receptor, delta 1
multiple interactions
EXP
Mercury inhibits the reaction [enkephalin, Ser(2), Leu(5), Thr(6)- binds to OPRD1 protein]
CTD
PMID:2162496
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
G
Oprk1
opioid receptor, kappa 1
multiple interactions
EXP
Mercury inhibits the reaction [Ethylketocyclazocine binds to OPRK1 protein]
CTD
PMID:2162496
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
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Oprm1
opioid receptor, mu 1
multiple interactions
EXP
Mercury inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
CTD
PMID:2162496
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
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Os9
OS9, endoplasmic reticulum lectin
decreases expression
ISO
Mercury results in decreased expression of OS9 mRNA
CTD
PMID:17547211
NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745
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P2rx2
purinergic receptor P2X 2
multiple interactions
EXP
Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]; methyl methanethiosulfonate inhibits the reaction [Mercury promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]
CTD
PMID:19793987
NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
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P2rx4
purinergic receptor P2X 4
multiple interactions
EXP
[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]; Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
CTD
PMID:10737610 PMID:15629187 PMID:19793987
NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
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Park7
Parkinsonism associated deglycase
increases expression affects binding
ISO
Mercury results in increased expression of PARK7 mRNA Mercury binds to PARK7 protein
CTD
PMID:16823088 PMID:23792957
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]
CTD
PMID:29115570
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pax6
paired box 6
multiple interactions
ISO
[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of PAX6 mRNA
CTD
PMID:37914285
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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Pcdhb5
protocadherin beta 5
decreases expression
ISO
Mercury results in decreased expression of PCDHB4 mRNA
CTD
PMID:22008530
NCBI chr18:29,024,315...29,032,183
Ensembl chr18:29,028,382...29,053,259
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Pde1a
phosphodiesterase 1A
decreases expression
ISO
Mercury results in decreased expression of PDE1A mRNA
CTD
PMID:22008530
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
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Pde4dip
phosphodiesterase 4D interacting protein
increases expression
ISO
Mercury results in increased expression of PDE4DIP mRNA
CTD
PMID:16823088
NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
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Pdia4
protein disulfide isomerase family A, member 4
decreases expression
ISO
Mercury results in decreased expression of PDIA4 mRNA
CTD
PMID:17547211
NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
G
Pds5b
PDS5 cohesin associated factor B
decreases expression
ISO
Mercury results in decreased expression of PDS5B mRNA
CTD
PMID:16823088
NCBI chr12:202,481...345,596
Ensembl chr12:255,313...345,596
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Pex14
peroxisomal biogenesis factor 14
increases expression
ISO
Mercury results in increased expression of PEX14 mRNA
CTD
PMID:16823088
NCBI chr 5:159,399,776...159,536,260
Ensembl chr 5:159,399,776...159,536,272
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Pfdn4
prefoldin subunit 4
decreases expression
ISO
Mercury analog results in decreased expression of PFDN4 mRNA
CTD
PMID:25056781
NCBI chr 3:159,303,173...159,311,221
Ensembl chr 3:159,303,071...159,311,219
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Pgc
progastricsin
decreases expression
ISO
Mercury results in decreased expression of PGC mRNA
CTD
PMID:17547211
NCBI chr 9:13,257,462...13,265,682
Ensembl chr 9:13,257,462...13,265,682
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Phox2b
paired-like homeobox 2b
increases expression
ISO
Mercury results in increased expression of PHOX2B mRNA
CTD
PMID:16823088
NCBI chr14:41,066,012...41,069,202
Ensembl chr14:41,066,264...41,068,978
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Pias2
protein inhibitor of activated STAT, 2
affects expression
ISO
Mercury affects the expression of PIAS2 mRNA
CTD
PMID:23920476
NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
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Pias4
protein inhibitor of activated STAT, 4
decreases expression
EXP
Mercury results in decreased expression of PIAS4 mRNA
CTD
PMID:22688007
NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:8,546,312...8,559,808
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
decreases expression
EXP
Mercury results in decreased expression of PIK3R1 mRNA
CTD
PMID:12730625
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
G
Pik3r4
phosphoinositide-3-kinase, regulatory subunit 4
increases expression
ISO
Mercury results in increased expression of PIK3R4 mRNA
CTD
PMID:16823088
NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
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Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
decreases expression
ISO
Mercury results in decreased expression of PIKFYVE mRNA
CTD
PMID:19937285
NCBI chr 9:66,563,747...66,657,873
Ensembl chr 9:66,563,727...66,657,868
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Pld1
phospholipase D1
increases phosphorylation
ISO
Mercury results in increased phosphorylation of PLD1 protein
CTD
PMID:21994240
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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Plppr4
phospholipid phosphatase related 4
increases expression
ISO
Mercury results in increased expression of PLPPR4 mRNA
CTD
PMID:16823088
NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302
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Plxnb3
plexin B3
decreases expression
ISO
Mercury analog results in decreased expression of PLXNB3 mRNA
CTD
PMID:25056781
NCBI chr X:151,493,832...151,508,688
Ensembl chr X:151,494,207...151,508,674
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Pmch
pro-melanin-concentrating hormone
decreases expression
ISO
Mercury results in decreased expression of PMCH mRNA
CTD
PMID:19937285
NCBI chr 7:22,511,934...22,513,250
Ensembl chr 7:22,511,934...22,513,250
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Pms1
PMS1 homolog 1, mismatch repair system component
decreases expression
ISO
Mercury analog results in decreased expression of PMS1 mRNA
CTD
PMID:25056781
NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237
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Pnma1
PNMA family member 1
decreases expression
ISO
Mercury results in decreased expression of PNMA1 mRNA
CTD
PMID:17547211
NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
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Pogk
pogo transposable element derived with KRAB domain
affects expression
ISO
Mercury affects the expression of POGK mRNA
CTD
PMID:16823088
NCBI chr13:78,647,447...78,663,363
Ensembl chr13:78,647,447...78,663,363
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Pold2
DNA polymerase delta 2, accessory subunit
affects expression
ISO
Mercury affects the expression of POLD2 mRNA
CTD
PMID:16823088
NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160
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Pon1
paraoxonase 1
decreases activity multiple interactions
ISO
Mercury results in decreased activity of PON1 protein Selenium inhibits the reaction [Mercury results in decreased activity of PON1 protein]
CTD
PMID:21543280
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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Pou2f3
POU class 2 homeobox 3
increases expression
ISO
Mercury results in increased expression of POU2F3 mRNA
CTD
PMID:16823088
NCBI chr 8:43,495,408...43,577,795
Ensembl chr 8:43,495,527...43,577,795
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Ppia
peptidylprolyl isomerase A
increases expression
ISO
Mercury results in increased expression of PPIA mRNA
CTD
PMID:16823088
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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Ppih
peptidylprolyl isomerase H
increases expression
ISO
Mercury results in increased expression of PPIH mRNA
CTD
PMID:17547211
NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267
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Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
increases expression
ISO
Mercury results in increased expression of PPP1R12A mRNA
CTD
PMID:16823088
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
decreases expression
ISO
Mercury results in decreased expression of PPP1R15A mRNA
CTD
PMID:16823088
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Ppp3cb
protein phosphatase 3 catalytic subunit beta
decreases expression
ISO
Mercury results in decreased expression of PPP3CB mRNA
CTD
PMID:22008530
NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
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Pprc1
PPARG related coactivator 1
affects response to substance
ISO
PPRC1 protein affects the susceptibility to Mercury
CTD
PMID:26942574
NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
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Ppt2
palmitoyl-protein thioesterase 2
decreases expression
ISO
Mercury results in decreased expression of PPT2 mRNA
CTD
PMID:19937285
NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774
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Prdx2
peroxiredoxin 2
increases expression
EXP
Mercury results in increased expression of PRDX2 mRNA
CTD
PMID:12730625
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
G
Prdx6
peroxiredoxin 6
decreases expression increases expression
ISO
Mercury results in decreased expression of PRDX6 mRNA Mercury analog results in increased expression of PRDX6 mRNA
CTD
PMID:16823088 PMID:25056781
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
G
Prkca
protein kinase C, alpha
increases expression
EXP
Mercury results in increased expression of PRKCA mRNA
CTD
PMID:12730625
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Prkcg
protein kinase C, gamma
increases expression
EXP
Mercury results in increased expression of PRKCG mRNA
CTD
PMID:12730625
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
G
Prkcq
protein kinase C, theta
decreases expression
ISO
Mercury analog results in decreased expression of PRKCQ mRNA
CTD
PMID:25056781
NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
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Prpf31
pre-mRNA processing factor 31
decreases expression
ISO
Mercury analog results in decreased expression of PRPF31 mRNA
CTD
PMID:25056781
NCBI chr 1:65,575,887...65,587,561
Ensembl chr 1:65,575,887...65,587,873
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Prpf40a
pre-mRNA processing factor 40 homolog A
decreases expression
ISO
Mercury analog results in decreased expression of PRPF40A mRNA
CTD
PMID:25056781
NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886
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Psph
phosphoserine phosphatase
decreases expression
ISO
Mercury results in decreased expression of PSPH mRNA
CTD
PMID:17547211
NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074
G
Ptbp1
polypyrimidine tract binding protein 1
decreases expression
ISO
Mercury analog results in decreased expression of PTBP1 mRNA
CTD
PMID:25056781
NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397
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Ptger2
prostaglandin E receptor 2
increases expression
EXP
Mercury results in increased expression of PTGER2 mRNA
CTD
PMID:12730625
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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Ptov1
PTOV1, extended AT-hook containing adaptor protein
decreases expression
ISO
Mercury analog results in decreased expression of PTOV1 mRNA
CTD
PMID:25056781
NCBI chr 1:95,347,065...95,354,514
Ensembl chr 1:95,347,068...95,353,613
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Pttg1
PTTG1 regulator of sister chromatid separation, securin
increases expression
ISO
Mercury results in increased expression of PTTG1 mRNA
CTD
PMID:17547211
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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Purb
purine rich element binding protein B
increases expression
ISO
Mercury analog results in increased expression of PURB mRNA
CTD
PMID:25056781
NCBI chr14:81,342,374...81,344,857
Ensembl chr14:81,336,448...81,351,432
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Pvalb
parvalbumin
decreases expression
ISO
Mercury analog results in decreased expression of PVALB mRNA
CTD
PMID:25056781
NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
G
Pxdn
peroxidasin
decreases expression
ISO
Mercury results in decreased expression of PXDN mRNA
CTD
PMID:19937285
NCBI chr 6:46,580,749...46,658,345
Ensembl chr 6:46,580,761...46,658,345
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Pxn
paxillin
affects localization
ISO
Mercury affects the localization of PXN protein
CTD
PMID:26600472
NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
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Rac1
Rac family small GTPase 1
increases expression
ISO
Mercury results in increased expression of RAC1 mRNA
CTD
PMID:16823088
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Racgap1
Rac GTPase-activating protein 1
increases expression
ISO
Mercury results in increased expression of RACGAP1 mRNA
CTD
PMID:17547211
NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
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Rad18
RAD18 E3 ubiquitin protein ligase
decreases expression
ISO
Mercury results in decreased expression of RAD18 mRNA
CTD
PMID:22641096
NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
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Ralgapa1
Ral GTPase activating protein catalytic subunit alpha 1
decreases expression
ISO
Mercury results in decreased expression of RALGAPA1 mRNA
CTD
PMID:19937285
NCBI chr 6:72,977,432...73,252,378
Ensembl chr 6:72,977,432...73,252,378
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Rara
retinoic acid receptor, alpha
decreases expression
EXP
Mercury results in decreased expression of RARA mRNA
CTD
PMID:22688007
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
G
Rbfox3
RNA binding fox-1 homolog 3
multiple interactions
ISO
[diethyl phosphate co-treated with Cotinine co-treated with bis(2,3,3,3-tetrachloropropyl) ether co-treated with Mercury co-treated with Selenium] results in increased expression of RBFOX3 mRNA
CTD
PMID:37914285
NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
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Rbm22
RNA binding motif protein 22
decreases expression
ISO
Mercury analog results in decreased expression of RBM22 mRNA
CTD
PMID:25056781
NCBI chr18:54,013,374...54,024,182
Ensembl chr18:54,013,351...54,024,569
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Rbpms
RNA binding protein, mRNA processing factor
increases expression
ISO
Mercury results in increased expression of RBPMS mRNA
CTD
PMID:17547211
NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO EXP
Mercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased localization of RELA protein] Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] [Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein
CTD
PMID:11437639 PMID:15282405 PMID:28035397
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Reln
reelin
decreases expression
ISO
Mercury results in decreased expression of RELN mRNA
CTD
PMID:17547211
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rhobtb2
Rho-related BTB domain containing 2
increases expression
ISO
Mercury results in increased expression of RHOBTB2 mRNA
CTD
PMID:16823088
NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651
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Rnaseh1
ribonuclease H1
decreases expression
ISO
Mercury results in decreased expression of RNASEH1 mRNA
CTD
PMID:16823088
NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236
G
Rnaseh2a
ribonuclease H2, subunit A
decreases expression increases expression
ISO
Mercury results in decreased expression of RNASEH2A mRNA Mercury results in increased expression of RNASEH2A mRNA
CTD
PMID:16823088 PMID:17547211
NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041
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Rnd2
Rho family GTPase 2
increases methylation
ISO
Mercury results in increased methylation of RND2 gene
CTD
PMID:21606628
NCBI chr10:86,399,151...86,402,750
Ensembl chr10:86,399,148...86,402,742
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Rnf138
ring finger protein 138
increases expression
ISO
Mercury results in increased expression of RNF138 mRNA
CTD
PMID:16823088
NCBI chr18:12,291,557...12,315,931
Ensembl chr18:12,291,590...12,315,930
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rnf141
ring finger protein 141
decreases expression
ISO
Mercury results in decreased expression of RNF141 mRNA
CTD
PMID:19937285
NCBI chr 1:164,933,972...164,957,081
Ensembl chr 1:164,931,077...164,957,118
G
Rngtt
RNA guanylyltransferase and 5'-phosphatase
affects expression
ISO
Mercury affects the expression of RNGTT mRNA
CTD
PMID:16823088
NCBI chr 5:47,706,929...47,913,297
Ensembl chr 5:47,706,799...47,913,295
G
Rpl19
ribosomal protein L19
decreases expression
ISO
Mercury results in decreased expression of RPL19 mRNA
CTD
PMID:16823088
NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
G
Rpl28
ribosomal protein L28
decreases expression
ISO
Mercury results in decreased expression of RPL28 mRNA
CTD
PMID:16823088
NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
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Rpp21
ribonuclease P/MRP subunit p21
decreases expression
ISO
Mercury analog results in decreased expression of RPP21 mRNA
CTD
PMID:25056781
NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106
G
Rps5
ribosomal protein S5
decreases expression
ISO
Mercury results in decreased expression of RPS5 mRNA
CTD
PMID:16823088
NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073
G
Rps6kc1
ribosomal protein S6 kinase C1
decreases expression
ISO
Mercury analog results in decreased expression of RPS6KC1 mRNA
CTD
PMID:25056781
NCBI chr13:102,346,160...102,491,000
Ensembl chr13:102,346,160...102,490,303
G
Rrbp1
ribosome binding protein 1
decreases expression
ISO
Mercury results in decreased expression of RRBP1 mRNA
CTD
PMID:19937285
NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
G
Rsad2
radical S-adenosyl methionine domain containing 2
multiple interactions
ISO
[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of RSAD2 mRNA
CTD
PMID:28453771
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
G
RT1-Ba
RT1 class II, locus Ba
decreases expression
ISO
Mercury results in decreased expression of HLA-DQA1 mRNA
CTD
PMID:16823088 PMID:19937285
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
G
RT1-Bb
RT1 class II, locus Bb
increases expression decreases expression
EXP ISO
Mercury results in increased expression of RT1-BB mRNA Mercury results in increased expression of HLA-DQB1 mRNA Mercury results in decreased expression of HLA-DQB1 mRNA
CTD
PMID:16823088 PMID:19937285 PMID:22688007
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
G
Rtn4
reticulon 4
decreases expression
ISO
Mercury results in decreased expression of RTN4 mRNA
CTD
PMID:19937285
NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
G
Rtp3
receptor (chemosensory) transporter protein 3
decreases expression
ISO
Mercury results in decreased expression of RTP3 mRNA
CTD
PMID:22008530
NCBI chr 8:110,970,154...110,975,000
Ensembl chr 8:110,970,160...110,974,699
G
Rubcnl
rubicon like autophagy enhancer
increases expression
ISO
Mercury results in increased expression of RUBCNL mRNA
CTD
PMID:16823088
NCBI chr15:50,332,458...50,377,494
Ensembl chr15:50,332,418...50,400,849
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S100a4
S100 calcium-binding protein A4
decreases expression
ISO
Mercury analog results in decreased expression of S100A4 mRNA
CTD
PMID:25056781
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S100b
S100 calcium binding protein B
increases secretion
ISO
Mercury results in increased secretion of S100B mRNA
CTD
PMID:30076900
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Sap30
Sin3A associated protein 30
increases expression
ISO
Mercury results in increased expression of SAP30 mRNA
CTD
PMID:16823088
NCBI chr16:32,747,777...32,753,114
Ensembl chr16:32,747,734...32,753,112
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Scaf4
SR-related CTD-associated factor 4
increases expression
ISO
Mercury results in increased expression of SCAF4 mRNA
CTD
PMID:16823088
NCBI chr11:29,460,479...29,521,153
Ensembl chr11:29,465,106...29,521,153
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Scarb1
scavenger receptor class B, member 1
increases expression
ISO
Mercury results in increased expression of SCARB1 mRNA
CTD
PMID:19937285
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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Scg3
secretogranin III
increases expression
ISO
Mercury results in increased expression of SCG3 mRNA
CTD
PMID:16823088
NCBI chr 8:76,399,777...76,442,015
Ensembl chr 8:76,399,777...76,442,015
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Sec24c
SEC24 homolog C, COPII coat complex component
increases expression
ISO
Mercury results in increased expression of SEC24C mRNA
CTD
PMID:16823088
NCBI chr15:3,602,460...3,624,524
Ensembl chr15:3,602,460...3,624,422
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Selenop
selenoprotein P
affects abundance increases expression multiple interactions
ISO
SELENOP gene polymorphism affects the abundance of Mercury Mercury results in increased expression of SELENOP protein [Mercury results in increased expression of SELENOP protein] which results in increased abundance of Selenium; SELENOP protein binds to and results in decreased susceptibility to Mercury
CTD
PMID:16451871 PMID:21967774 PMID:27989593
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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Senp6
SUMO specific peptidase 6
increases expression
ISO
Mercury results in increased expression of SENP6 mRNA
CTD
PMID:16823088
NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170
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Serpina3n
serpin family A member 3N
affects expression
ISO
Mercury affects the expression of SERPINA3 protein
CTD
PMID:22030286
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Serpinb1a
serpin family B member 1A
decreases expression
ISO
Mercury results in decreased expression of SERPINB1 mRNA
CTD
PMID:17547211
NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
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Serpinc1
serpin family C member 1
decreases expression
ISO
Mercury results in decreased expression of SERPINC1 mRNA
CTD
PMID:17547211
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serping1
serpin family G member 1
affects expression
ISO
Mercury affects the expression of SERPING1 protein
CTD
PMID:22030286
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Sfrp1
secreted frizzled-related protein 1
decreases expression
ISO
Mercury results in decreased expression of SFRP1 mRNA
CTD
PMID:19937285
NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286
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Sh3bp2
SH3-domain binding protein 2
increases expression
ISO
Mercury results in increased expression of SH3BP2 mRNA
CTD
PMID:19937285
NCBI chr14:76,176,097...76,213,300
Ensembl chr14:76,176,101...76,213,251
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Sh3glb2
SH3 domain-containing GRB2-like endophilin B2
increases expression
ISO
Mercury results in increased expression of SH3GLB2 mRNA
CTD
PMID:16823088
NCBI chr 3:13,616,936...13,631,785
Ensembl chr 3:13,616,938...13,631,757
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Sh3pxd2a
SH3 and PX domains 2A
increases expression
ISO
Mercury results in increased expression of SH3PXD2A mRNA
CTD
PMID:16823088
NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
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Shc1
SHC adaptor protein 1
decreases expression
ISO
Mercury results in decreased expression of SHC1 mRNA
CTD
PMID:16823088
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Sirt5
sirtuin 5
decreases expression
ISO
Mercury analog results in decreased expression of SIRT5 mRNA
CTD
PMID:25056781
NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101
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Slc11a1
solute carrier family 11 member 1
increases expression
ISO
Mercury results in increased expression of SLC11A1 mRNA
CTD
PMID:19937285
NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
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Slc11a2
solute carrier family 11 member 2
decreases expression multiple interactions increases uptake
ISO
Mercury results in decreased expression of SLC11A2 mRNA [HAMP protein results in decreased expression of SLC11A2 mRNA] which results in decreased uptake of Mercury SLC11A2 mRNA results in increased uptake of Mercury SLC11A2 results in increased uptake of Mercury
CTD
PMID:25772431
NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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Slc12a2
solute carrier family 12 member 2
affects transport
EXP
SLC12A2 protein mutant form affects the transport of Mercury
CTD
PMID:12556450
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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Slc18a2
solute carrier family 18 member A2
decreases expression
ISO
Mercury analog results in decreased expression of SLC18A2 mRNA
CTD
PMID:25056781
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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Slc22a1
solute carrier family 22 member 1
increases expression
EXP
Mercury results in increased expression of SLC22A1 mRNA
CTD
PMID:12730625
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a19
solute carrier family 22, member 19
multiple interactions increases expression
EXP
EPO protein inhibits the reaction [Mercury results in increased expression of SLC22A19 protein]
CTD
PMID:32909846
NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538
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Slc22a4
solute carrier family 22 member 4
multiple interactions
ISO
Acetylcysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Cysteine inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Mercury binds to and results in decreased activity of SLC22A4 protein
CTD
PMID:25490951
NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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Slc22a6
solute carrier family 22 member 6
multiple interactions affects response to substance
ISO EXP
SLC22A6 gene SNP affects the susceptibility to and affects the abundance of Mercury; SLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury] SLC22A6 gene SNP affects the susceptibility to Mercury EPO protein promotes the reaction [Mercury results in increased expression of and affects the localization of SLC22A6 protein]; Mercury results in increased expression of and affects the localization of SLC22A6 protein
CTD
PMID:15908511 PMID:23052037 PMID:32909846 PMID:32946573
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO EXP
[SLC22A8 gene SNP affects the susceptibility to Mercury] which affects the abundance of Mercury; SLC22A8 gene SNP affects the susceptibility to and affects the abundance of Mercury EPO protein affects the reaction [Mercury affects the localization of SLC22A8 protein]; EPO protein promotes the reaction [Mercury results in increased expression of SLC22A8 protein]; Mercury results in increased expression of and affects the localization of SLC22A8 protein
CTD
PMID:23052037 PMID:32909846 PMID:32946573
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slc25a22
solute carrier family 25 member 22
decreases expression
ISO
Mercury results in decreased expression of SLC25A22 mRNA
CTD
PMID:19937285
NCBI chr 1:196,528,471...196,536,398
Ensembl chr 1:196,528,472...196,536,331
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Slc2a4
solute carrier family 2 member 4
decreases expression
EXP
Mercury results in decreased expression of SLC2A4 mRNA
CTD
PMID:22688007
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc30a1
solute carrier family 30 member 1
increases expression
EXP
Mercury results in increased expression of SLC30A1 mRNA
CTD
PMID:12730625
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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Slc39a8
solute carrier family 39 member 8
multiple interactions
ISO
Mercury inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]
CTD
PMID:16638970
NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
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Slc3a2
solute carrier family 3 member 2
affects import
ISO
SLC3A2 protein affects the import of Mercury
CTD
PMID:28786956
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc6a4
solute carrier family 6 member 4
affects response to substance
ISO
SLC6A4 promoter polymorphism affects the susceptibility to Mercury
CTD
PMID:20526950
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Slc7a2
solute carrier family 7 member 2
decreases expression
ISO
Mercury results in decreased expression of SLC7A2 mRNA
CTD
PMID:19937285
NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
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Slc7a5
solute carrier family 7 member 5
multiple interactions
ISO
SLC7A5 gene SNP affects the susceptibility to and affects the abundance of Mercury
CTD
PMID:23052037
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slit3
slit guidance ligand 3
decreases expression
ISO
Mercury results in decreased expression of SLIT3 mRNA
CTD
PMID:16823088
NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
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Smad2
SMAD family member 2
increases expression
ISO
Mercury results in increased expression of SMAD2 mRNA
CTD
PMID:19937285
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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Smc4
structural maintenance of chromosomes 4
increases expression
ISO
Mercury results in increased expression of SMC4 mRNA
CTD
PMID:17547211
NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
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Smim14
small integral membrane protein 14
increases expression
ISO
Mercury results in increased expression of SMIM14 mRNA
CTD
PMID:16823088
NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760
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Snrpa
small nuclear ribonucleoprotein polypeptide A
increases expression
ISO
Mercury results in increased expression of SNRPA mRNA
CTD
PMID:17547211
NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538
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Sod1
superoxide dismutase 1
increases expression multiple interactions
EXP
Mercury results in increased expression of SOD1 mRNA [Mercury co-treated with Hydrogen Peroxide] results in increased expression of SOD1 mRNA
CTD
PMID:23578882
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
decreases expression
ISO
Mercury analog results in decreased expression of SOS1 mRNA
CTD
PMID:25056781
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
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Sox18
SRY-box transcription factor 18
increases expression
ISO
Mercury results in increased expression of SOX18 mRNA
CTD
PMID:16823088
NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
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Spink1
serine peptidase inhibitor, Kazal type 1
decreases expression
EXP
Mercury results in decreased expression of SPINK1 mRNA
CTD
PMID:22688007
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Mercury results in increased expression of SPP1 mRNA
CTD
PMID:17547211
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Sptbn1
spectrin, beta, non-erythrocytic 1
increases expression
ISO
Mercury results in increased expression of SPTBN1 mRNA
CTD
PMID:16823088
NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
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Srf
serum response factor
decreases expression
ISO
Mercury results in decreased expression of SRF mRNA
CTD
PMID:16823088
NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
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Srpk3
SRSF protein kinase 3
decreases expression
ISO
Mercury analog results in decreased expression of SRPK3 mRNA
CTD
PMID:25056781
NCBI chr X:151,510,452...151,515,208
Ensembl chr X:151,510,539...151,515,198
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Srsf2
serine and arginine rich splicing factor 2
increases expression
ISO
Mercury results in increased expression of SRSF2 mRNA
CTD
PMID:17547211
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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Srsf7
serine and arginine rich splicing factor 7
increases expression
ISO
Mercury results in increased expression of SRSF7 mRNA
CTD
PMID:17547211
NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
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Ssbp1
single stranded DNA binding protein 1
increases expression
ISO
Mercury results in increased expression of SSBP1 mRNA
CTD
PMID:19937285
NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135
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Ssr2
signal sequence receptor subunit 2
decreases expression
ISO
Mercury results in decreased expression of SSR2 mRNA
CTD
PMID:16823088
NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042
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Sstr3
somatostatin receptor 3
decreases expression
ISO
Mercury results in decreased expression of SSTR3 mRNA
CTD
PMID:19937285
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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Stk24
serine/threonine kinase 24
decreases expression
ISO
Mercury analog results in decreased expression of STK24 mRNA
CTD
PMID:25056781
NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553
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Stub1
STIP1 homology and U-box containing protein 1
decreases expression
ISO
Mercury results in decreased expression of STUB1 mRNA
CTD
PMID:19937285
NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
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Sub1
SUB1 regulator of transcription
decreases expression
ISO
Mercury results in decreased expression of SUB1 mRNA
CTD
PMID:19937285
NCBI chr 2:61,005,646...61,020,486
Ensembl chr 2:61,005,666...61,020,436 Ensembl chr 2:61,005,666...61,020,436
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Szrd1
SUZ RNA binding domain containing 1
affects expression
ISO
Mercury affects the expression of SZRD1 mRNA
CTD
PMID:16823088
NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
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Tac1
tachykinin, precursor 1
increases expression
ISO
Mercury results in increased expression of TAC1 mRNA
CTD
PMID:16823088
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tap1
transporter 1, ATP binding cassette subfamily B member
decreases expression
EXP
Mercury results in decreased expression of TAP1 mRNA
CTD
PMID:22688007
NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901
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Tardbp
TAR DNA binding protein
multiple interactions
ISO
[methylmercuric chloride results in increased abundance of Mercury] which affects the localization of TARDBP protein
CTD
PMID:30371865
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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Tat
tyrosine aminotransferase
increases activity multiple interactions
EXP
Mercury results in increased activity of TAT protein Mercury inhibits the reaction [Dexamethasone results in increased activity of TAT protein]
CTD
PMID:16307467
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Tcf3
transcription factor 3
decreases expression
ISO
Mercury results in decreased expression of TCF3 mRNA
CTD
PMID:19937285
NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
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Tes
testin LIM domain protein
decreases expression
ISO
Mercury results in decreased expression of TES mRNA
CTD
PMID:22008530
NCBI chr 4:45,365,304...45,403,829
Ensembl chr 4:45,365,285...45,403,829
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Tf
transferrin
increases secretion
ISO
Mercury results in increased secretion of TF protein
CTD
PMID:10798623
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tgfb2
transforming growth factor, beta 2
increases expression
ISO
Mercury results in increased expression of TGFB2 mRNA
CTD
PMID:16823088
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Them6
thioesterase superfamily member 6
decreases expression
ISO
Mercury analog results in decreased expression of THEM6 mRNA
CTD
PMID:25056781
NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746
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Thumpd2
THUMP domain containing 2
decreases expression
ISO
Mercury analog results in decreased expression of THUMPD2 mRNA
CTD
PMID:25056781
NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657
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Thumpd3
THUMP domain containing 3
decreases expression
ISO
Mercury results in decreased expression of THUMPD3 mRNA
CTD
PMID:22008530
NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246
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Timm13
translocase of inner mitochondrial membrane 13
decreases expression
EXP
Mercury results in decreased expression of TIMM13 mRNA
CTD
PMID:22688007
NCBI chr 7:8,809,069...8,810,172
Ensembl chr 7:8,809,058...8,809,910
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Timm23
translocase of inner mitochondrial membrane 23
increases expression
EXP
Mercury results in increased expression of TIMM23 mRNA
CTD
PMID:22688007
NCBI chr16:7,410,308...7,436,392
Ensembl chr16:7,409,688...7,436,379 Ensembl chr 3:7,409,688...7,436,379 Ensembl chr 6:7,409,688...7,436,379
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Tjp1
tight junction protein 1
decreases expression
ISO
Mercury results in decreased expression of TJP1 mRNA
CTD
PMID:37137463
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tk2
thymidine kinase 2
affects expression
ISO
Mercury affects the expression of TK2 mRNA
CTD
PMID:16823088
NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
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Tm2d1
TM2 domain containing 1
increases expression
ISO
Mercury results in increased expression of TM2D1 mRNA
CTD
PMID:16823088
NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933
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Tmf1
TATA element modulatory factor 1
decreases expression
ISO
Mercury results in decreased expression of TMF1 mRNA
CTD
PMID:16823088
NCBI chr 4:129,759,952...129,785,705
Ensembl chr 4:129,763,114...129,785,629
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Tnf
tumor necrosis factor
increases expression multiple interactions affects expression
EXP ISO
Mercury results in increased expression of TNF mRNA Mercury promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Mercury results in increased expression of TNF protein Mercury affects the expression of TNF mRNA [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein; [Selenium co-treated with Zinc] inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Selenium inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein]; Zinc inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Arsenic] results in increased expression of TNF protein] [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA; CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of TNF mRNA]; N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline inhibits the reaction [Mercury results in increased expression of TNF mRNA] Mercury results in increased expression of TNF mRNA; Mercury results in increased expression of TNF protein
CTD
PMID:12730625 PMID:12928768 PMID:15282405 PMID:20176347 PMID:20600710 PMID:25237059 PMID:28453771 PMID:37137463 PMID:37415728 PMID:37676925 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip3
TNF alpha induced protein 3
increases expression
ISO
Mercury results in increased expression of TNFAIP3 mRNA
CTD
PMID:17547211
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfaip8
TNF alpha induced protein 8
increases expression decreases expression
ISO EXP
Mercury results in increased expression of TNFAIP8 mRNA Mercury results in decreased expression of TNFAIP8 mRNA
CTD
PMID:17547211 PMID:22688007
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
EXP
Mercury results in increased expression of TNFRSF1A mRNA; Mercury results in increased expression of TNFRSF1A protein
CTD
PMID:12730625
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfsf10
TNF superfamily member 10
decreases expression
ISO
Mercury results in decreased expression of TNFSF10 mRNA
CTD
PMID:17547211
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tns2
tensin 2
decreases expression
ISO
Mercury analog results in decreased expression of TNS2 mRNA
CTD
PMID:25056781
NCBI chr 7:133,229,746...133,247,889
Ensembl chr 7:133,206,364...133,247,888
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Tox3
TOX high mobility group box family member 3
increases expression
ISO
Mercury results in increased expression of TOX3 mRNA
CTD
PMID:16823088
NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148
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Tp53
tumor protein p53
affects folding
ISO
Mercury affects the folding of TRP53 protein
CTD
PMID:8467489
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpm2
tropomyosin 2
increases expression
ISO
Mercury results in increased expression of TPM2 mRNA
CTD
PMID:16823088
NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
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Tradd
TNFRSF1A-associated via death domain
increases expression
EXP
Mercury results in increased expression of TRADD protein
CTD
PMID:12730625
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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Trib3
tribbles pseudokinase 3
decreases expression
ISO
Mercury results in decreased expression of TRIB3 mRNA
CTD
PMID:19937285
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trip13
thyroid hormone receptor interactor 13
increases expression
ISO
Mercury results in increased expression of TRIP13 mRNA
CTD
PMID:17547211
NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
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Tspan7
tetraspanin 7
decreases expression
ISO
Mercury results in decreased expression of TSPAN7 mRNA
CTD
PMID:17547211
NCBI chr X:12,208,783...12,306,092
Ensembl chr X:12,208,783...12,306,131
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Tst
thiosulfate sulfurtransferase
decreases expression
ISO
Mercury results in decreased expression of TST mRNA
CTD
PMID:17547211
NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216
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Tuba8
tubulin, alpha 8
decreases expression
ISO
Mercury analog results in decreased expression of TUBA8 mRNA
CTD
PMID:25056781
NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917
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Twf2
twinfilin actin-binding protein 2
decreases expression
ISO
Mercury results in decreased expression of TWF2 mRNA
CTD
PMID:16823088
NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298
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Txn1
thioredoxin 1
affects binding
ISO
Mercury binds to TXN protein
CTD
PMID:18321861
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txndc11
thioredoxin domain containing 11
decreases expression
ISO
Mercury analog results in decreased expression of TXNDC11 mRNA
CTD
PMID:25056781
NCBI chr10:4,515,457...4,572,999
Ensembl chr10:4,515,478...4,572,989
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Mercury results in increased expression of TXNRD1 mRNA
CTD
PMID:17547211
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Txnrd2
thioredoxin reductase 2
decreases activity
EXP
Mercury results in decreased activity of TXNRD2 protein
CTD
PMID:17157198
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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Tyms
thymidylate synthetase
increases expression
ISO
Mercury results in increased expression of TYMS mRNA
CTD
PMID:17547211
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Ube2c
ubiquitin-conjugating enzyme E2C
increases expression
ISO
Mercury results in increased expression of UBE2C mRNA
CTD
PMID:17547211
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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Ube2l3
ubiquitin-conjugating enzyme E2L 3
decreases expression
ISO
Mercury analog results in decreased expression of UBE2L3 mRNA
CTD
PMID:25056781
NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862
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Ube2n
ubiquitin-conjugating enzyme E2N
decreases expression
ISO
Mercury results in decreased expression of UBE2N mRNA
CTD
PMID:16823088
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
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Ugcg
UDP-glucose ceramide glucosyltransferase
increases expression
ISO
Mercury results in increased expression of UGCG mRNA
CTD
PMID:17547211
NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
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Uqcrb
ubiquinol-cytochrome c reductase binding protein
increases expression
ISO
Mercury results in increased expression of UQCRB mRNA
CTD
PMID:16823088
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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Urod
uroporphyrinogen decarboxylase
decreases activity
ISO
Mercury results in decreased activity of UROD protein
CTD
PMID:15967199
NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808
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Usp39
ubiquitin specific peptidase 39
increases expression
ISO
Mercury results in increased expression of USP39 mRNA
CTD
PMID:16823088
NCBI chr 4:104,373,948...104,406,359
Ensembl chr 4:104,373,955...104,406,359
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Usp53
ubiquitin specific peptidase 53
decreases expression
ISO
Mercury analog results in decreased expression of USP53 mRNA
CTD
PMID:25056781
NCBI chr 2:211,059,512...211,120,942
Ensembl chr 2:211,059,520...211,120,943
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Uspl1
ubiquitin specific peptidase like 1
increases expression
ISO
Mercury results in increased expression of USPL1 mRNA
CTD
PMID:16823088
NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366
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Vasp
vasodilator-stimulated phosphoprotein
decreases expression
ISO
Mercury analog results in decreased expression of VASP mRNA
CTD
PMID:25056781
NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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Vdr
vitamin D receptor
affects abundance
ISO
VDR gene polymorphism affects the abundance of Mercury
CTD
PMID:25728017
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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Vim
vimentin
increases expression
ISO
Mercury results in increased expression of VIM mRNA
CTD
PMID:26600472
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Vps36
vacuolar protein sorting 36 homolog
decreases expression
ISO
Mercury analog results in decreased expression of VPS36 mRNA
CTD
PMID:25056781
NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810
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Vtn
vitronectin
decreases expression
ISO
Mercury results in decreased expression of VTN mRNA
CTD
PMID:17547211
NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
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Vwa1
von Willebrand factor A domain containing 1
increases expression
ISO
Mercury results in increased expression of VWA1 mRNA
CTD
PMID:16823088
NCBI chr 5:166,377,451...166,382,784
Ensembl chr 5:166,377,455...166,382,637
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Wdr12
WD repeat domain 12
decreases expression
EXP
Mercury results in decreased expression of WDR12 mRNA
CTD
PMID:22688007
NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469
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Wipi1
WD repeat domain, phosphoinositide interacting 1
decreases expression
ISO
Mercury results in decreased expression of WIPI1 mRNA
CTD
PMID:22008530
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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Xist
X inactive specific transcript
increases expression
ISO
Mercury results in increased expression of XIST mRNA
CTD
PMID:22008530
NCBI chr X:68,474,987...68,492,500
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Ybx1
Y box binding protein 1
increases expression
ISO
Mercury results in increased expression of YBX1 mRNA
CTD
PMID:16823088
NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
decreases expression
ISO
Mercury analog results in decreased expression of YWHAQ mRNA
CTD
PMID:25056781
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
decreases expression
ISO
Mercury results in decreased expression of YWHAZ mRNA
CTD
PMID:16823088
NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
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Zbtb1
zinc finger and BTB domain containing 1
increases expression
ISO
Mercury results in increased expression of ZBTB1 mRNA
CTD
PMID:16823088
NCBI chr 6:95,096,838...95,125,811
Ensembl chr 6:95,096,387...95,118,996
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Zbtb10
zinc finger and BTB domain containing 10
increases expression
ISO
Mercury results in increased expression of ZBTB10 mRNA
CTD
PMID:16823088
NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515
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Zbtb16
zinc finger and BTB domain containing 16
increases expression
ISO
Mercury results in increased expression of ZBTB16 mRNA
CTD
PMID:19937285
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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Zbtb38
zinc finger and BTB domain containing 38
increases expression
ISO
Mercury results in increased expression of ZBTB38 mRNA
CTD
PMID:19937285
NCBI chr 8:97,284,617...97,288,518
Ensembl chr 8:97,280,993...97,485,625
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Zfand3
zinc finger AN1-type containing 3
decreases expression
ISO
Mercury analog results in decreased expression of ZFAND3 mRNA
CTD
PMID:25056781
NCBI chr20:8,083,407...8,279,617
Ensembl chr20:8,082,200...8,279,616
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Zfhx4
zinc finger homeobox 4
decreases expression
ISO
Mercury analog results in decreased expression of ZFHX4 mRNA
CTD
PMID:25056781
NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228
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Zfp174
zinc finger protein 174
decreases expression
ISO
Mercury results in decreased expression of ZNF174 mRNA
CTD
PMID:19937285
NCBI chr10:11,666,580...11,676,328
Ensembl chr10:11,669,913...11,676,312
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Zfp866
zinc finger protein 866
increases expression
EXP
Mercury results in increased expression of CXCL5 mRNA
CTD
PMID:12730625
NCBI chr16:19,653,966...19,675,968
Ensembl chr16:19,668,258...19,675,932
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Zfp950
zinc finger protein 950
increases expression
ISO
Mercury results in increased expression of ZNF80 mRNA
CTD
PMID:16823088
NCBI chr 1:260,248,231...260,265,211
Ensembl chr 1:260,236,599...260,265,254
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Zwint
ZW10 interacting kinetochore protein
increases expression
ISO
Mercury results in increased expression of ZWINT mRNA
CTD
PMID:17547211
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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