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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ceftibuten
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Accession:CHEBI:3510 term browser browse the term
Definition:A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to treat urinary-tract and respiratory-tract infections.
Synonyms:exact_synonym: 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (+)-(6R,7R)-7-((Z)-2-(2-amino-4-thiazolyl)-4-carboxycrotonamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;   (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   Formula=C15H14N4O6S2;   InChI=1S/C15H14N4O6S2/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25)/b6-1-/t10-,13-/m1/s1;   InChIKey=UNJFKXSSGBWRBZ-BJCIPQKHSA-N;   SMILES=[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=C/CC(O)=O)\\c1csc(N)n1)C(O)=O;   ceftibutene;   ceftibuteno;   ceftibutenum;   cis-ceftibuten
 alt_id: CHEBI:554578
 xref: Beilstein:5892046;   CAS:97519-39-6;   DrugBank:DB01415;   Drug_Central:562;   KEGG:C08117;   KEGG:D00922
 xref_mesh: MESH:C054360
 xref: PMID:29017833;   PMID:9250548;   Patent:CN105153198;   Patent:CN106397455;   Patent:EP136721;   Patent:US4634697;   Wikipedia:Ceftibuten


show annotations for term's descendants           Sort by:
ceftibuten term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of ceftibuten CTD PMID:14567632 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake
multiple interactions		 ISO SLC22A6 protein results in increased uptake of ceftibuten
ceftibuten inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]		 CTD PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions		 ISO SLC22A8 protein results in increased uptake of ceftibuten
ceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]		 CTD PMID:16098483 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        antimicrobial agent 18250
          antibacterial agent 16369
            antibacterial drug 7393
              ceftibuten 3
                ceftibuten dihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              lactam 8390
                                                beta-lactam 828
                                                  beta-lactam antibiotic 813
                                                    cephem 549
                                                      cephalosporin 548
                                                        ceftibuten 3
                                                          ceftibuten dihydrate 0
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