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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saxitoxin
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Accession:CHEBI:34970 term browser browse the term
Definition:An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.
Synonyms:related_synonym: [(3aS,4R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
 xref: CAS:35523-89-8;   Chemspider:34106;   HMDB:HMDB0029368;   KNApSAcK:C00051761
 xref_mesh: MESH:D012530
 xref: Reaxys:47858;   foodb.food:FDB000437;   kegg.compound:C13757;   pubmed:22628533;   pubmed:23966031;   pubmed:24184516;   pubmed:24460188;   pubmed:32323358;   pubmed:32485372;   pubmed:33086288;   pubmed:33104353;   pubmed:33113659;   pubmed:33526182;   pubmed:33748075;   pubmed:33813339;   wikipedia.en:Saxitoxin
 chemrof_formula: C10H17N7O4
 chemrof_inchi: InChI=1S/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16)/t4-,5-,10-/m0/s1
 chemrof_inchikey: RPQXVSUAYFXFJA-HGRQIUPRSA-N
 chemrof_smiles: [H][C@@]12NC(=N)N[C@]13N(CCC3(O)O)C(=N)N[C@H]2COC(N)=O
 cyclic_relationship: is_conjugate_base_of CHEBI:180458


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saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity 		ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein 		CTD PMID:29128272 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Alb albumin decreases expression ISO Saxitoxin results in decreased expression of ALB protein CTD PMID:29228856 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO Saxitoxin results in decreased expression of ARPC5L protein CTD PMID:29228856 NCBI chr 3:43,169,518...43,177,224
Ensembl chr 3:43,169,462...43,177,240
Ensembl chr 9:43,169,462...43,177,240 		JBrowse link
G Cfl2 cofilin 2 affects expression ISO Saxitoxin affects the expression of CFL2 protein CTD PMID:29228856 NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888 		JBrowse link
G Eno1 enolase 1 affects expression ISO Saxitoxin affects the expression of ENO1 protein CTD PMID:29228856 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Saxitoxin results in decreased expression of HNRNPL protein CTD PMID:29228856 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Saxitoxin results in decreased expression of VDAC1 protein CTD PMID:29228856 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:37,023,145...37,060,541 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO Saxitoxin results in increased expression of YWHAB protein CTD PMID:29228856 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        poison 17837
          toxin 16034
            saxitoxin 8
              saxitoxin acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterotricyclic compound 16085
                                      pyrrolopurine 9
                                        paralytic shellfish toxin 9
                                          saxitoxin 8
                                            saxitoxin acetate 0
paths to the root