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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:saxitoxin
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Accession:CHEBI:34970 term browser browse the term
Definition:An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.
Synonyms:exact_synonym: [(3aS,4R,10aS)-10,10-dihydroxy-2,6-diiminooctahydro-1H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
 related_synonym: Formula=C10H17N7O4;   InChI=1S/C10H17N7O4/c11-6-15-5-4(3-21-8(13)18)14-7(12)17-2-1-9(19,20)10(5,17)16-6/h4-5,19-20H,1-3H2,(H2,12,14)(H2,13,18)(H3,11,15,16)/t4-,5-,10-/m0/s1;   InChIKey=RPQXVSUAYFXFJA-HGRQIUPRSA-N;   SMILES=NC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]22NC(=N)N[C@@H]12
 xref: CAS:35523-89-8;   Chemspider:34106;   FooDB:FDB000437;   HMDB:HMDB0029368;   KEGG:C13757;   KNApSAcK:C00051761
 xref_mesh: MESH:D012530
 xref: PMID:22628533;   PMID:23966031;   PMID:24184516;   PMID:24460188;   PMID:32323358;   PMID:32485372;   PMID:33086288;   PMID:33104353;   PMID:33113659;   PMID:33526182;   PMID:33748075;   PMID:33813339;   Reaxys:47858;   Wikipedia:Saxitoxin
 cyclic_relationship: is_conjugate_base_of CHEBI:180458


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saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity		 ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein		 CTD PMID:29128272 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Alb albumin decreases expression ISO Saxitoxin results in decreased expression of ALB protein CTD PMID:29228856 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO Saxitoxin results in decreased expression of ARPC5L protein CTD PMID:29228856 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
Ensembl chr 9:22,759,876...22,767,538 		JBrowse link
G Cfl2 cofilin 2 affects expression ISO Saxitoxin affects the expression of CFL2 protein CTD PMID:29228856 NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674 		JBrowse link
G Eno1 enolase 1 affects expression ISO Saxitoxin affects the expression of ENO1 protein CTD PMID:29228856 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Saxitoxin results in decreased expression of HNRNPL protein CTD PMID:29228856 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Saxitoxin results in decreased expression of VDAC1 protein CTD PMID:29228856 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO Saxitoxin results in increased expression of YWHAB protein CTD PMID:29228856 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105 		JBrowse link
neosaxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:32471037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        poison 18612
          toxin 16004
            saxitoxin 9
              neosaxitoxin 1
              saxitoxin acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15845
                                      pyrrolopurine 9
                                        paralytic shellfish toxin 9
                                          saxitoxin 9
                                            neosaxitoxin 1
                                            saxitoxin acetate 0
paths to the root