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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ruthenium red
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Accession:CHEBI:34956 term browser browse the term
Definition:A ruthenium coordination entity that has formula H42N14O2Ru3.6Cl.
Synonyms:exact_synonym: tetradecaammine-1kappa(5)N,2kappa(5)N,3kappa(4)N-di-mu-oxidotriruthenium hexachloride
 related_synonym: Formula=Cl6H42N14O2Ru3;   Formula=H42N14O2Ru3.6Cl;   InChI=1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6;   InChIKey=ZXYSDUPLHOJIOR-UHFFFAOYSA-H;   SMILES=[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[H][N+]([H])([H])[Ru--](O[Ru-3]([N+]([H])([H])[H])([N+]([H])([H])[H])([N+]([H])([H])[H])([N+]([H])([H])[H])[N+]([H])([H])[H])(O[Ru-3]([N+]([H])([H])[H])([N+]([H])([H])[H])([N+]([H])([H])[H])([N+]([H])([H])[H])[N+]([H])([H])[H])([N+]([H])([H])[H])([N+]([H])([H])[H])[N+]([H])([H])[H];   [{Ru(NH3)5}(mu-O){Ru(NH3)4}(mu-O){Ru(NH3)5}]Cl6;   tetradecaammine dioxotriruthenium hexachloride
 xref: CAS:25125-46-6;   Gmelin:53071;   KEGG:C13932
 xref_mesh: MESH:D012430
 xref: Reaxys:14328304;   Reaxys:14404389;   Reaxys:15563844


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ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] CTD PMID:32652086 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] CTD PMID:32652086 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Agrp agouti related neuropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] CTD PMID:32652086 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG5 protein] CTD PMID:34308505 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG7 protein] CTD PMID:34308505 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Aconitine co-treated with Ruthenium Red] results in increased expression of BAX protein CTD PMID:37506855 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein] CTD PMID:17828286 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:19631781 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]
[Aconitine co-treated with Ruthenium Red] results in increased cleavage of CASP3 protein		 CTD PMID:19631781 PMID:23219522 PMID:37506855 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cck cholecystokinin multiple interactions ISO [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein] CTD PMID:26979077 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]		 CTD PMID:16173059 PMID:32652086 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lep leptin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased lipidation of MAP1LC3B protein] CTD PMID:34308505 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP		 Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcu mitochondrial calcium uniporter multiple interactions ISO [Aconitine co-treated with Ruthenium Red] results in increased expression of MCU protein CTD PMID:37506855 NCBI chr20:27,417,529...27,580,110
Ensembl chr20:27,417,526...27,580,110 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein] CTD PMID:20886221 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Micu1 mitochondrial calcium uptake 1 multiple interactions ISO Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of MICU1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of MICU1 protein] CTD PMID:37337224 NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964 		JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions		 ISO Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein
Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]		 CTD PMID:17508023 PMID:21245013 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21466812 PMID:22882778 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:20886221 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein] CTD PMID:37337224 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Pyy peptide YY multiple interactions ISO [Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form] CTD PMID:26979077 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein] CTD PMID:32652086 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
decreases activity		 ISO Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]
Ruthenium Red results in decreased activity of TRPA1 protein
Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]		 CTD PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects binding		 ISO
EXP		 Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]
Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]
Ruthenium Red binds to TRPV1 protein		 CTD PMID:11140687 PMID:18172555 PMID:18230619 PMID:23264033 PMID:23747933 More... NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions EXP
ISO		 Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]		 CTD PMID:20086034 PMID:32652086 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions
decreases activity		 EXP [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      molecular entity 19872
        transition element molecular entity 17435
          transition element coordination entity 11731
            ruthenium coordination entity 42
              ruthenium red 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  metal atom 18028
                    transition element atom 17572
                      d-block element atom 17567
                        iron group element atom 1724
                          ruthenium atom 61
                            ruthenium molecular entity 42
                              ruthenium coordination entity 42
                                ruthenium red 42
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