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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentetrazol
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Accession:CHEBI:34910 term browser browse the term
Definition:An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Synonyms:related_synonym: 1,5-pentamethylenetetrazole;   6,7,8,9-tetrahydro-5-azepotetrazole;   6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine;   7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene;   Cardiazol;   Cardiazole;   Cardifortan;   Cardiotonicum;   Cardosal;   Cardosan;   Cenalene-M;   Cenazol;   Coranormol;   Coratoline;   Corazol;   Corazole;   Corvasol;   Coryvet;   Deumacard;   Diovascole;   Gewazol;   Kardiazol;   Korazol;   Metrazol;   Pentylenetetrazole;   Phrenazol;   Ventrazol;   alpha,beta-cyclopentamethylenetetrazole;   pentamethylene-1,5-tetrazole;   pentetrazolum;   pentylenetetrazol
 xref: CAS:54-95-5
 xref_mesh: MESH:D010433
 xref: Patent:US1564631;   Patent:US1599493;   Reaxys:135492;   drugcentral:3428;   kegg.compound:C13692;   kegg.drug:D07409;   lincs.smallmolecule:LSM-3287;   pubmed:19797046;   pubmed:21689733;   pubmed:22049436;   pubmed:23852314;   pubmed:23893477;   pubmed:24397543;   wikipedia.en:Pentylenetetrazol
 chemrof_smiles: C1CCc2nnnn2CC1
 chemrof_formula: C6H10N4
 chemrof_inchikey: CWRVKFFCRWGWCS-UHFFFAOYSA-N
 chemrof_inchi: InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2


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pentetrazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase increases response to substance ISO ABAT mRNA results in increased susceptibility to Pentylenetetrazole CTD PMID:10850552 NCBI chr10:7,503,351...7,599,474
Ensembl chr10:7,492,022...7,599,474 		JBrowse link
G Ache acetylcholinesterase increases activity
multiple interactions 		EXP Pentylenetetrazole results in increased activity of ACHE protein
Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of ACHE protein] 		CTD PMID:35833322 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pentylenetetrazole CTD PMID:19488739 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions 		EXP Pentylenetetrazole results in increased expression of AGER protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of AGER protein] 		CTD PMID:32653415 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions 		EXP Pentylenetetrazole results in increased expression of AKT1 mRNA
Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of AKT1 mRNA] 		CTD PMID:34266355 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
decreases activity 		ISO carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein] CTD PMID:25490531 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression 		EXP Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of APP protein]
Pentylenetetrazole results in increased expression of APP mRNA; Pentylenetetrazole results in increased expression of APP protein 		CTD PMID:9720974 PMID:32653415 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression 		EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BACE1 protein] CTD PMID:32653415 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
decreases expression 		EXP
ISO 		Pentylenetetrazole results in increased expression of BDNF mRNA; Pentylenetetrazole results in increased expression of BDNF protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BDNF protein]
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein] 		CTD PMID:11279263 PMID:32450180 PMID:32653415 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression 		EXP Thiamine inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 mRNA]
Pentylenetetrazole results in increased expression of CASP3 mRNA; Pentylenetetrazole results in increased expression of CASP3 protein 		CTD PMID:33771525 PMID:34266355 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity
increases activity 		EXP
ISO 		Pentylenetetrazole results in decreased expression of CAT protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of CAT protein] 		CTD PMID:16122723 PMID:32450180 PMID:35833322 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases response to substance ISO CNR1 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26460022 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO
EXP 		Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentylenetetrazole results in increased expression of FOS mRNA; Pentylenetetrazole results in increased expression of FOS protein
delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein] 		CTD PMID:1380685 PMID:3037702 PMID:7534335 PMID:7887109 PMID:8809800 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr14:37,451,218...37,587,458
Ensembl chr14:37,450,683...37,587,457 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:27,438,127...27,657,680
Ensembl chr10:27,438,238...27,655,171 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,876,926...26,965,523 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance ISO GAD2 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:8954991 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089 		JBrowse link
G Gcg glucagon decreases expression
multiple interactions 		EXP Pentylenetetrazole results in decreased expression of GCG protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased expression of GCG protein] 		CTD PMID:32653415 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:67,522,489...67,531,533 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions 		EXP Pentylenetetrazole results in decreased phosphorylation of GSK3B protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased phosphorylation of GSK3B protein] 		CTD PMID:32653415 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity 		EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of GSR protein] CTD PMID:35833322 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions 		ISO Pentylenetetrazole results in decreased expression of HMOX1 protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein] 		CTD PMID:32450180 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression
multiple interactions 		EXP Pentylenetetrazole results in increased expression of IGF1 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of IGF1 protein] 		CTD PMID:32653415 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26910900 NCBI chr 3:188,572,345...188,631,391
Ensembl chr 3:188,572,926...188,631,302 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation 		EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased phosphorylation of MAPT protein] CTD PMID:32653415 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions 		EXP Pentylenetetrazole results in increased expression of MMP9 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of MMP9 protein] 		CTD PMID:32653415 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Pentylenetetrazole CTD PMID:14960011 NCBI chr 5:100,812,121...100,966,566
Ensembl chr 5:100,812,124...100,966,504 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity 		EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of MPO protein] CTD PMID:35833322 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions 		ISO Pentylenetetrazole results in increased expression of NR4A1 mRNA
Dexamethasone inhibits the reaction [Pentylenetetrazole results in increased expression of NR4A1 mRNA] 		CTD PMID:8164692 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Pentylenetetrazole results in increased expression of NR4A2 mRNA CTD PMID:8164692 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769 		JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Pentylenetetrazole CTD PMID:18657176 NCBI chr 9:71,616,602...71,731,869
Ensembl chr 9:71,616,657...71,731,871 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in decreased susceptibility to Pentylenetetrazole] CTD PMID:23638761 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:8,935,523...10,077,374 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 gene results in decreased susceptibility to Pentylenetetrazole CTD PMID:17126860 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase affects response to substance ISO PAM protein affects the susceptibility to Pentylenetetrazole CTD PMID:19815072 NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:105,445,929...105,719,285 		JBrowse link
G Pdyn prodynorphin increases cleavage
decreases expression 		EXP Pentylenetetrazole results in increased cleavage of PDYN protein
Pentylenetetrazole results in decreased expression of PDYN mRNA 		CTD PMID:1465197 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503 		JBrowse link
G Rps6 ribosomal protein S6 increases expression
multiple interactions 		EXP Pentylenetetrazole results in increased expression of RPS6 mRNA
Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of RPS6 mRNA] 		CTD PMID:34266355 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:106,417,680...106,420,566 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Pentylenetetrazole CTD PMID:15911120 NCBI chr19:30,183,289...30,228,292
Ensembl chr19:30,183,383...30,223,348 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Pentylenetetrazole results in decreased expression of SOD1 protein CTD PMID:16122723 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions 		ISO Pentylenetetrazole results in increased expression of VEGFA protein
daidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein] 		CTD PMID:32450180 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity 		EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of XDH protein] CTD PMID:35833322 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          nitrogen atom 19576
            nitrogen molecular entity 19576
              organonitrogen compound 19311
                organonitrogen heterocyclic compound 18491
                  pentetrazol 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      p-block molecular entity 20796
                        carbon group molecular entity 20724
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterobicyclic compound 17442
                                      pentetrazol 42
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