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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pentetrazol
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Accession:CHEBI:34910 term browser browse the term
Definition:An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Synonyms:related_synonym: 1,5-pentamethylenetetrazole;   6,7,8,9-tetrahydro-5-azepotetrazole;   6,7,8,9-tetrahydro-5H-tetrazolo[1,5-a]azepine;   7,8,9,10-tetrazabicyclo[5.3.0]-8,10-decadiene;   Cardiazol;   Cardiazole;   Cardifortan;   Cardiotonicum;   Cardosal;   Cardosan;   Cenalene-M;   Cenazol;   Coranormol;   Coratoline;   Corazol;   Corazole;   Corvasol;   Coryvet;   Deumacard;   Diovascole;   Formula=C6H10N4;   Gewazol;   InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2;   InChIKey=CWRVKFFCRWGWCS-UHFFFAOYSA-N;   Kardiazol;   Korazol;   Metrazol;   Pentylenetetrazole;   Phrenazol;   SMILES=C1CCc2nnnn2CC1;   Ventrazol;   alpha,beta-cyclopentamethylenetetrazole;   pentamethylene-1,5-tetrazole;   pentetrazolum;   pentylenetetrazol
 xref: CAS:54-95-5;   Drug_Central:3428;   KEGG:C13692;   KEGG:D07409;   LINCS:LSM-3287
 xref_mesh: MESH:D010433
 xref: PMID:19797046;   PMID:21689733;   PMID:22049436;   PMID:23852314;   PMID:23893477;   PMID:24397543;   Patent:US1564631;   Patent:US1599493;   Reaxys:135492;   Wikipedia:Pentylenetetrazol


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pentetrazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase increases response to substance ISO ABAT mRNA results in increased susceptibility to Pentylenetetrazole CTD PMID:10850552 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Ache acetylcholinesterase increases activity
multiple interactions		 EXP Pentylenetetrazole results in increased activity of ACHE protein
Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of ACHE protein]		 CTD PMID:35833322 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adora2a adenosine A2a receptor affects response to substance ISO ADORA2A protein affects the susceptibility to Pentylenetetrazole CTD PMID:19488739 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
multiple interactions		 EXP Pentylenetetrazole results in increased expression of AGER protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of AGER protein]		 CTD PMID:32653415 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 EXP Pentylenetetrazole results in increased expression of AKT1 mRNA
Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of AKT1 mRNA]		 CTD PMID:34266355 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase multiple interactions
decreases activity		 ISO carvacryl acetate inhibits the reaction [Pentylenetetrazole results in decreased activity of ALAD protein] CTD PMID:25490531 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression		 EXP Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of APP protein]
Pentylenetetrazole results in increased expression of APP mRNA; Pentylenetetrazole results in increased expression of APP protein		 CTD PMID:9720974 PMID:32653415 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions
increases expression		 EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BACE1 protein] CTD PMID:32653415 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
decreases expression		 EXP
ISO		 Pentylenetetrazole results in increased expression of BDNF mRNA; Pentylenetetrazole results in increased expression of BDNF protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of BDNF protein]
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein]		 CTD PMID:11279263 PMID:32450180 PMID:32653415 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression		 EXP Thiamine inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 mRNA]
Pentylenetetrazole results in increased expression of CASP3 mRNA; Pentylenetetrazole results in increased expression of CASP3 protein		 CTD PMID:33771525 PMID:34266355 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression
multiple interactions
decreases activity
increases activity		 EXP
ISO		 Pentylenetetrazole results in decreased expression of CAT protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein]
Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of CAT protein]		 CTD PMID:16122723 PMID:32450180 PMID:35833322 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases response to substance ISO CNR1 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26460022 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]
Pentylenetetrazole results in increased expression of FOS mRNA; Pentylenetetrazole results in increased expression of FOS protein
delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]		 CTD PMID:1380685 PMID:3037702 PMID:7534335 PMID:7887109 PMID:8809800 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Pentylenetetrazole inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:14637376 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases response to substance ISO GAD2 gene mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:8954991 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gcg glucagon decreases expression
multiple interactions		 EXP Pentylenetetrazole results in decreased expression of GCG protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased expression of GCG protein]		 CTD PMID:32653415 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
multiple interactions		 EXP Pentylenetetrazole results in decreased phosphorylation of GSK3B protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in decreased phosphorylation of GSK3B protein]		 CTD PMID:32653415 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity		 EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of GSR protein] CTD PMID:35833322 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions		 ISO Pentylenetetrazole results in decreased expression of HMOX1 protein
daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein]		 CTD PMID:32450180 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression
multiple interactions		 EXP Pentylenetetrazole results in increased expression of IGF1 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of IGF1 protein]		 CTD PMID:32653415 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Pentylenetetrazole CTD PMID:26910900 NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases phosphorylation		 EXP Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased phosphorylation of MAPT protein] CTD PMID:32653415 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 EXP Pentylenetetrazole results in increased expression of MMP9 protein
Sitagliptin Phosphate inhibits the reaction [Pentylenetetrazole results in increased expression of MMP9 protein]		 CTD PMID:32653415 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Pentylenetetrazole CTD PMID:14960011 NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of MPO protein] CTD PMID:35833322 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions		 ISO Pentylenetetrazole results in increased expression of NR4A1 mRNA
Dexamethasone inhibits the reaction [Pentylenetetrazole results in increased expression of NR4A1 mRNA]		 CTD PMID:8164692 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Pentylenetetrazole results in increased expression of NR4A2 mRNA CTD PMID:8164692 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Pentylenetetrazole CTD PMID:18657176 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO NRXN1 protein affects the reaction [NLG-1 results in decreased susceptibility to Pentylenetetrazole] CTD PMID:23638761 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases response to substance ISO OPRK1 gene results in decreased susceptibility to Pentylenetetrazole CTD PMID:17126860 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase affects response to substance ISO PAM protein affects the susceptibility to Pentylenetetrazole CTD PMID:19815072 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pdyn prodynorphin increases cleavage
decreases expression		 EXP Pentylenetetrazole results in increased cleavage of PDYN protein
Pentylenetetrazole results in decreased expression of PDYN mRNA		 CTD PMID:1465197 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Rps6 ribosomal protein S6 increases expression
multiple interactions		 EXP Pentylenetetrazole results in increased expression of RPS6 mRNA
Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of RPS6 mRNA]		 CTD PMID:34266355 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Pentylenetetrazole CTD PMID:15911120 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP Pentylenetetrazole results in decreased expression of SOD1 protein CTD PMID:16122723 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO Pentylenetetrazole results in increased expression of VEGFA protein
daidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]		 CTD PMID:32450180 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity		 EXP Vitamin U inhibits the reaction [Pentylenetetrazole results in increased activity of XDH protein] CTD PMID:35833322 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    chemical entity 19878
      atom 19878
        nonmetal atom 19800
          nitrogen atom 18979
            nitrogen molecular entity 18979
              organonitrogen compound 18833
                organonitrogen heterocyclic compound 18153
                  pentetrazol 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      p-block molecular entity 19817
                        carbon group molecular entity 19757
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      pentetrazol 42
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