paxilline - Ontology Report - Rat Genome Database

paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Creb1

cAMP responsive element binding protein 1

multiple interactions

paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

Fasn

fatty acid synthase

multiple interactions
increases expression

[Bexarotene co-treated with paxilline] results in increased expression of FASN mRNA; [CD 3254 co-treated with paxilline] results in increased expression of FASN mRNA
paxilline results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

Flt1

Fms related receptor tyrosine kinase 1

multiple interactions

paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]

PMID:25371888

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

Kcnma1

potassium calcium-activated channel subfamily M alpha 1

affects response to substance

EXP

KCNMA1 protein affects the susceptibility to paxilline

PMID:22226998

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

Mlxipl

MLX interacting protein-like

increases expression

paxilline results in increased expression of MLXIPL mRNA

NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112

Nr0b2

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression

[Bexarotene co-treated with paxilline] results in increased expression of NR0B2 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of NR0B2 mRNA
paxilline results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

Nr1h3

nuclear receptor subfamily 1, group H, member 3

multiple interactions
increases expression

[Bexarotene co-treated with paxilline] results in increased expression of NR1H3 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of NR1H3 mRNA; NR1H3 protein promotes the reaction [paxilline results in increased abundance of Lipids]
paxilline results in increased expression of NR1H3 mRNA

PMID:20079722 PMID:32123961

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

Nrip1

nuclear receptor interacting protein 1

multiple interactions
increases expression

[CD 3254 co-treated with paxilline] results in increased expression of NRIP1 mRNA
paxilline results in increased expression of NRIP1 mRNA

NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761

Pten

phosphatase and tensin homolog

multiple interactions

paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

Scd

stearoyl-CoA desaturase

multiple interactions
increases expression

[CD 3254 co-treated with paxilline] results in increased expression of SCD mRNA
paxilline results in increased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

Srebf1

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

[Bexarotene co-treated with paxilline] results in increased expression of SREBF1 mRNA; [CD 3254 co-treated with paxilline] results in increased expression of SREBF1 mRNA
paxilline results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

Tnf

tumor necrosis factor

multiple interactions

paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of AKT1 protein]]; paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in decreased phosphorylation of CREB1 protein]]; paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]]