nickel dichloride - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nickel dichloride	go back to main search page
Accession:	CHEBI:34887	browse the term
Definition:	A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Synonyms:	exact_synonym:	nickel(2+) chloride
	related_synonym:	Formula=Cl2Ni; InChI=1S/2ClH.Ni/h2*1H;/q;;+2/p-2; InChIKey=QMMRZOWCJAIUJA-UHFFFAOYSA-L; NiCl2; Nickel chloride; Nickel(II) chloride; SMILES=Cl[Ni]Cl; nickelous chloride
	xref:	CAS:7718-54-9; KEGG:C14711
	xref_mesh:	MESH:C022838
	xref:	PMID:11739495; PMID:12603851; PMID:21928331; PMID:23179351; PMID:23622879; PMID:23702803; PMID:23735035; PMID:7671317; Reaxys:3902827; Reaxys:8128171; Wikipedia:Nickel_dichloride

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Genes (1028)

nickel dichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

increases expression

nickel chloride results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

decreases response to substance
increases expression
multiple interactions

ABCB1 protein results in decreased susceptibility to nickel chloride
nickel chloride results in increased expression of ABCB1 mRNA; nickel chloride results in increased expression of ABCB1 protein
alpha-Tocopherol inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]; fumonisin B1 inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

increases expression

nickel chloride results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily G member 1

increases expression

nickel chloride results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ankyrin repeat and BTB domain containing 1

affects expression

nickel chloride affects the expression of ABTB1 mRNA

NCBI chr 4:121,299,302...121,305,667
Ensembl chr 4:121,299,304...121,305,620

G

acyl-CoA dehydrogenase medium chain

decreases expression

nickel chloride results in decreased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

atypical chemokine receptor 3

increases expression

nickel chloride results in increased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

ATP citrate lyase

affects expression

nickel chloride affects the expression of ACLY mRNA

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

aconitase 1

decreases activity
increases activity
multiple interactions

nickel chloride results in decreased activity of ACO1 protein
nickel chloride results in increased activity of ACO1 protein
[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]; [nickel chloride results in increased activity of ACO1 protein] which results in increased expression of and results in increased stability of TFRC mRNA; Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein]

PMID:16039939 PMID:16649251 PMID:17018869

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

decreases activity

nickel chloride results in decreased activity of ACO2 protein

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA oxidase 1

decreases expression

nickel chloride results in decreased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA synthetase family member 2

affects expression

nickel chloride affects the expression of ACSF2 mRNA

NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673

G

acyl-CoA synthetase long-chain family member 1

decreases expression
affects expression

nickel chloride results in decreased expression of ACSL1 mRNA
nickel chloride affects the expression of ACSL1 mRNA

PMID:17547211 PMID:22110744

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

nickel chloride results in increased expression of ACTA2 mRNA; nickel chloride results in increased expression of ACTA2 protein
sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 mRNA]; sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of ACTA2 protein]
[nickel chloride results in increased abundance of Nickel] which results in increased expression of ACTA2 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ACTA2 protein; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ACTA2 protein]; CTH gene mutant form promotes the reaction [nickel chloride results in increased expression of ACTA2 protein]

PMID:30055191 PMID:38488660

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

decreases expression
increases expression

nickel chloride results in decreased expression of ACTB protein
nickel chloride results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

actinin alpha 2

affects expression

nickel chloride affects the expression of ACTN2 mRNA

NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622

G

ADAM metallopeptidase domain 17

affects expression

nickel chloride affects the expression of ADAM17 mRNA

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

adenylate cyclase activating polypeptide 1

multiple interactions
decreases activity

nickel chloride inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA]
nickel chloride results in decreased activity of ADCYAP1 protein

PMID:18198219 PMID:22009744

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

G

adrenomedullin

increases expression
affects expression

nickel chloride results in increased expression of ADM mRNA
nickel chloride affects the expression of ADM mRNA

PMID:17312168 PMID:17547211 PMID:21455298 PMID:22110744

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

alpha-fetoprotein

affects expression

nickel chloride affects the expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

apoptosis inducing factor, mitochondria associated 1

affects expression

nickel chloride affects the expression of AIFM1 mRNA

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AIF family member 2

affects expression

nickel chloride affects the expression of AIFM2 mRNA

NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

nickel chloride results in decreased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

aryl hydrocarbon receptor-interacting protein-like 1

affects expression

nickel chloride affects the expression of AIPL1 mRNA

NCBI chr10:56,655,693...56,664,922
Ensembl chr10:56,655,693...56,664,922

G

adenylate kinase 1

affects expression

nickel chloride affects the expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

adenylate kinase 3

increases expression

nickel chloride results in increased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

adenylate kinase 4

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of AK4 mRNA
nickel chloride affects the expression of AK4 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]

PMID:12729255 PMID:22110744

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

A-kinase anchoring protein 11

decreases expression

nickel chloride results in decreased expression of AKAP11 mRNA

NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605

G

aldo-keto reductase family 1 member B1

decreases expression

nickel chloride results in decreased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1, member D1

affects expression

nickel chloride affects the expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

AKT serine/threonine kinase 1

multiple interactions
decreases response to substance
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; [nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of AKT1 protein; [nickel chloride results in increased phosphorylation of AKT1 protein] which results in decreased activity of and results in increased phosphorylation of GSK3B protein; nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]
AKT1 protein results in decreased susceptibility to nickel chloride
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; [nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA; [nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein; AKT1 protein affects the reaction [nickel chloride results in increased expression of HIF1A protein]; AKT1 protein affects the reaction [nickel chloride results in increased expression of NDRG1 protein]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]

PMID:14729612 PMID:21837363 PMID:23828460 PMID:25614230 PMID:30724446 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

affects expression

nickel chloride affects the expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

multiple interactions

[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
increases expression

nickel chloride results in decreased expression of ALDH1A1 mRNA
nickel chloride results in increased expression of ALDH1A1 protein

PMID:12729255 PMID:14645679 PMID:26962057

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

affects expression

nickel chloride affects the expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions
affects expression

nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of ALDH3A1 mRNA]
nickel chloride affects the expression of ALDH3A1 mRNA

PMID:14645679 PMID:22110744

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aldolase, fructose-bisphosphate C

increases expression
multiple interactions

nickel chloride results in increased expression of ALDOA mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA]

PMID:12426141 PMID:12839937

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alpha-methylacyl-CoA racemase

affects expression

nickel chloride affects the expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

adenosine monophosphate deaminase 3

affects expression

nickel chloride affects the expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

anaphase promoting complex subunit 4

affects expression

nickel chloride affects the expression of ANAPC4 mRNA

NCBI chr14:58,125,995...58,159,253
Ensembl chr14:58,125,995...58,157,770

G

anaphase promoting complex subunit 7

affects expression

nickel chloride affects the expression of ANAPC7 mRNA

NCBI chr12:34,131,214...34,160,819
Ensembl chr12:34,133,429...34,160,005

G

angiopoietin-like 4

increases expression
multiple interactions

nickel chloride results in increased expression of ANGPTL4 mRNA
[nickel chloride results in increased abundance of Nickel] which results in decreased methylation of ANGPTL4 promoter; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ANGPTL4 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ANGPTL4 protein; TET1 protein affects the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ANGPTL4 mRNA]; TET1 protein affects the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ANGPTL4 protein]

PMID:17312168 PMID:21455298 PMID:34571076

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat domain 37

increases expression
affects expression

nickel chloride results in increased expression of ANKRD37 mRNA
nickel chloride affects the expression of ANKRD37 mRNA

PMID:21455298 PMID:22110744

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

annexin A2

affects expression
increases expression

nickel chloride affects the expression of ANXA2 mRNA
nickel chloride results in increased expression of ANXA2 protein

PMID:11250053 PMID:22110744

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

amyloid beta precursor protein binding family B member 1

affects expression

nickel chloride affects the expression of APBB1 mRNA

NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627

G

amyloid beta precursor protein binding family B member 2

affects expression

nickel chloride affects the expression of APBB2 mRNA

NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495

G

amyloid beta precursor protein binding family B member 3

affects expression

nickel chloride affects the expression of APBB3 mRNA

NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094

G

APC regulator of WNT signaling pathway

affects expression

nickel chloride affects the expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 2

affects expression

nickel chloride affects the expression of APEX2 mRNA

NCBI chr X:19,425,684...19,508,459
Ensembl chr X:19,487,419...19,508,439

G

apelin

affects expression

nickel chloride affects the expression of APLN mRNA

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

apolipoprotein L2

increases expression

nickel chloride results in increased expression of APOL2 mRNA

NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558

G

A-Raf proto-oncogene, serine/threonine kinase

affects expression

nickel chloride affects the expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

arginase 1

affects expression

nickel chloride affects the expression of ARG1 mRNA

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rac/Cdc42 guanine nucleotide exchange factor 6

affects expression

nickel chloride affects the expression of ARHGEF6 mRNA

NCBI chr X:135,145,447...135,264,636
Ensembl chr X:135,146,786...135,275,304

G

ARL6 interacting reticulophagy regulator 1

affects expression

nickel chloride affects the expression of ARL6IP1 mRNA

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

HIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]
nickel chloride promotes the reaction [HIF1A protein binds to ARNT protein]

PMID:12729255 PMID:29355601

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin, beta 2

affects localization

nickel chloride affects the localization of ARRB2 protein

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

arrestin domain containing 4

increases expression

nickel chloride results in increased expression of ARRDC4 mRNA

NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290

G

acid sensing ion channel subunit 2

affects expression

nickel chloride affects the expression of ASIC2 mRNA

NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424

G

argininosuccinate lyase

affects expression

nickel chloride affects the expression of ASL mRNA

NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

nickel chloride results in increased expression of ASNS mRNA

PMID:17312168 PMID:17547211

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 2

multiple interactions

[nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of ATF2 protein

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 3

increases expression
affects expression

nickel chloride results in increased expression of ATF3 mRNA
nickel chloride affects the expression of ATF3 mRNA

PMID:17312168 PMID:22110744

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

autophagy related 5

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of ATG7 mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of ATG7 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of ATG7 protein]
nickel chloride results in increased expression of ATG7 mRNA; nickel chloride results in increased expression of ATG7 protein

PMID:35568058 PMID:36421005

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATM serine/threonine kinase

increases expression
affects expression

nickel chloride results in increased expression of ATM mRNA
nickel chloride affects the expression of ATM mRNA

PMID:12426141 PMID:12839937 PMID:22546817

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

decreases expression

nickel chloride results in decreased expression of ATP2A2 mRNA

NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101

G

aurora kinase A

affects expression

nickel chloride affects the expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

alpha-2-glycoprotein 1, zinc-binding

affects expression

nickel chloride affects the expression of AZGP1 mRNA

NCBI chr12:16,930,990...16,939,333
Ensembl chr12:16,931,024...16,939,091

G

BTB domain and CNC homolog 1

increases expression

nickel chloride results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2-associated agonist of cell death

increases expression
affects expression

nickel chloride results in increased expression of BAD protein
nickel chloride affects the expression of BAD mRNA

PMID:20391133 PMID:22546817

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 1

affects expression

nickel chloride affects the expression of BAG1 mRNA

NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075

G

BAG cochaperone 3

affects expression

nickel chloride affects the expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

increases expression
affects expression

nickel chloride results in increased expression of BAK1 mRNA
nickel chloride affects the expression of BAK1 mRNA

PMID:21843586 PMID:22546817

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
affects expression

nickel chloride results in increased expression of BAX protein
Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BAX protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of BAX mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of BAX protein]
nickel chloride results in increased expression of BAX mRNA; nickel chloride results in increased expression of BAX protein
[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BAX protein]
nickel chloride affects the expression of BAX mRNA

PMID:20391133 PMID:22546817 PMID:31943712 PMID:36421005

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of BBC3 mRNA
nickel chloride affects the expression of BBC3 mRNA
TP53 protein affects the reaction [nickel chloride results in increased expression of BBC3 mRNA]

PMID:22546817 PMID:23566959 PMID:28552779

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCAR3 adaptor protein, NSP family member

affects expression

nickel chloride affects the expression of BCAR3 mRNA

NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798

G

BCL10, immune signaling adaptor

affects expression

nickel chloride affects the expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
decreases response to substance
increases expression

nickel chloride results in decreased expression of BCL2 mRNA
nickel chloride results in decreased expression of BCL2 mRNA; nickel chloride results in decreased expression of BCL2 protein
Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of BCL2 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of BCL2 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to nickel chloride
nickel chloride results in increased expression of BCL2 protein

PMID:17442357 PMID:20391133 PMID:21837363 PMID:23828460 PMID:36421005

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

nickel chloride results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

increases expression
decreases response to substance
affects expression
decreases expression

nickel chloride results in increased expression of BCL2L1 protein
BCL2L1 protein results in decreased susceptibility to nickel chloride
nickel chloride affects the expression of BCL2L1 mRNA
nickel chloride results in decreased expression of BCL2L1 protein

PMID:20391133 PMID:21837363 PMID:22546817 PMID:23828460

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 10

affects expression

nickel chloride affects the expression of BCL2L10 mRNA

NCBI chr 8:76,107,326...76,113,373
Ensembl chr 8:76,107,326...76,113,367

G

Bcl2-like 11

affects expression

nickel chloride affects the expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

Bcl2-like 13

affects expression

nickel chloride affects the expression of BCL2L13 mRNA

NCBI chr 4:154,056,116...154,112,890
Ensembl chr 4:154,056,127...154,108,985

G

Bcl2-like 2

affects expression

nickel chloride affects the expression of BCL2L2 mRNA

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL3, transcription coactivator

affects expression

nickel chloride affects the expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

affects expression

nickel chloride affects the expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

affects expression

nickel chloride affects the expression of BCS1L mRNA

NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938

G

beclin 1

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; [nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of BECN1 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of BECN1 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of BECN1 protein]
nickel chloride results in increased expression of BECN1 mRNA; nickel chloride results in increased expression of BECN1 protein

PMID:35568058 PMID:36421005

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

brain expressed X-linked 3

affects expression

nickel chloride affects the expression of BEX3 mRNA

NCBI chr X:99,273,270...99,274,799
Ensembl chr X:99,273,161...99,274,800

G

basic helix-loop-helix family, member e41

affects expression

nickel chloride affects the expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

BH3 interacting domain death agonist

increases expression
affects expression

nickel chloride results in increased expression of BID mRNA
nickel chloride affects the expression of BID mRNA

PMID:21843586 PMID:22546817

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BCL2-interacting killer

affects expression

nickel chloride affects the expression of BIK mRNA

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

G

baculoviral IAP repeat-containing 3

increases expression
affects expression

nickel chloride results in increased expression of BIRC3 mRNA
nickel chloride affects the expression of BIRC3 mRNA

PMID:17312168 PMID:22546817

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

affects expression

nickel chloride affects the expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basophilic leukemia expressed protein BLES03

decreases expression

nickel chloride results in decreased expression of BLES03 mRNA

NCBI chr 1:202,734,555...202,736,809
Ensembl chr 1:202,734,555...202,736,804

G

Bcl2 modifying factor

affects expression

nickel chloride affects the expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BCL2 interacting protein 3

increases expression
multiple interactions
affects expression

nickel chloride results in increased expression of BNIP3 mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]
nickel chloride affects the expression of BNIP3 mRNA
[nickel chloride results in increased abundance of Nickel] which results in increased expression of BNIP3 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of BNIP3 protein; HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]

PMID:12426141 PMID:12729255 PMID:12839937 PMID:17312168 PMID:22110744 More...

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

increases expression
affects expression

nickel chloride results in increased expression of BNIP3L mRNA
nickel chloride affects the expression of BNIP3L mRNA

PMID:21455298 PMID:22110744 PMID:22546817

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

G

BCL2 family apoptosis regulator BOK

affects expression

nickel chloride affects the expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

BRCA1, DNA repair associated

decreases expression

nickel chloride results in decreased expression of BRCA1 mRNA; nickel chloride results in decreased expression of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

BMP/retinoic acid inducible neural specific 2

affects expression

nickel chloride affects the expression of BRINP2 mRNA

NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810

G

bone marrow stromal cell antigen 2

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

biotinidase

affects expression

nickel chloride affects the expression of BTD mRNA

NCBI chr16:6,863,068...6,894,345
Ensembl chr16:6,862,407...6,940,945

G

BTG anti-proliferation factor 1

increases expression

nickel chloride results in increased expression of BTG1 mRNA

NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649

G

BTG anti-proliferation factor 2

multiple interactions
increases expression

TP53 protein affects the reaction [nickel chloride results in increased expression of BTG2 mRNA]

PMID:23566959 PMID:28552779

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BTG anti-proliferation factor 3

affects expression

nickel chloride affects the expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

basic leucine zipper and W2 domains 1

affects expression

nickel chloride affects the expression of BZW1 mRNA

NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430

G

complement C1s

affects expression

nickel chloride affects the expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

C2 calcium-dependent domain containing 4D

affects expression

nickel chloride affects the expression of C2CD4D mRNA

NCBI chr 2:181,999,778...182,001,941
Ensembl chr 2:181,997,078...182,002,087

G

complement C3

affects expression

nickel chloride affects the expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 15 open reading frame 48

increases expression

nickel chloride results in increased expression of C15ORF48 mRNA

NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006

G

complement C7

affects expression

nickel chloride affects the expression of C7 mRNA

NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535

G

complement C8 beta chain

affects expression

nickel chloride affects the expression of C8B mRNA

NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565

G

complement C9

affects expression

nickel chloride affects the expression of C9 mRNA

NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338

G

calmodulin 1

affects expression

nickel chloride affects the expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin 2

affects expression

nickel chloride affects the expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calcium/calmodulin-dependent protein kinase II beta

affects expression

nickel chloride affects the expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calcium/calmodulin-dependent protein kinase II delta

affects expression

nickel chloride affects the expression of CAMK2D mRNA

NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178

G

calcium/calmodulin-dependent protein kinase II gamma

affects expression

nickel chloride affects the expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

carbonic anhydrase 9

increases expression
multiple interactions

nickel chloride results in increased expression of CA9 mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]

PMID:21455298 PMID:28552779

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

caspase recruitment domain family, member 10

affects expression

nickel chloride affects the expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

G

caspase recruitment domain family, member 9

affects expression

nickel chloride affects the expression of CARD9 mRNA

NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237

G

cysteinyl-tRNA synthetase 1

increases expression

nickel chloride results in increased expression of CARS1 mRNA

NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941

G

caspase 1

multiple interactions

[[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein] which results in increased secretion of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP1 protein; [Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP1 protein]
CASP1 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]

PMID:24158569 PMID:31943712

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 2

affects expression

nickel chloride affects the expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity
multiple interactions
increases expression
increases cleavage
affects expression

nickel chloride results in increased activity of CASP3 protein
Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP3 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CASP3 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CASP3 protein]
nickel chloride results in increased expression of CASP3 mRNA; nickel chloride results in increased expression of CASP3 protein
nickel chloride results in increased expression of CASP3 mRNA; nickel chloride results in increased expression of CASP3 protein modified form
nickel chloride results in increased cleavage of CASP3 protein
nickel chloride affects the expression of CASP3 mRNA
[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP3 protein; [TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]] which results in decreased cleavage of CASP3 protein; cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of CASP3 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased cleavage of CASP3 protein]
pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP3 protein]

PMID:21828359 PMID:21843586 PMID:22172632 PMID:22546817 PMID:23566959 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

affects expression

nickel chloride affects the expression of CASP6 mRNA

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

multiple interactions
increases cleavage
affects expression
increases activity

pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP7 protein]
nickel chloride results in increased cleavage of CASP7 protein
cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of CASP7 protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of CASP7 protein]
nickel chloride affects the expression of CASP7 mRNA

PMID:21828359 PMID:21843586 PMID:22172632 PMID:22546817 PMID:28552779

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

affects expression

nickel chloride affects the expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases expression
multiple interactions
decreases expression
affects expression

nickel chloride results in increased activity of CASP9 protein
nickel chloride results in increased expression of CASP9 mRNA; nickel chloride results in increased expression of CASP9 protein
Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CASP9 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CASP9 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CASP9 protein]
nickel chloride results in decreased expression of CASP9 protein
nickel chloride affects the expression of CASP9 mRNA
[TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]] which results in decreased cleavage of CASP3 protein; pifithrin inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]
pyrazolanthrone inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]

PMID:21843586 PMID:22546817 PMID:23566959 PMID:28552779 PMID:36421005

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases response to substance
decreases activity
multiple interactions
decreases expression

CAT protein results in decreased susceptibility to nickel chloride
nickel chloride results in decreased activity of CAT protein
chromous chloride affects the reaction [nickel chloride results in decreased activity of CAT protein]; nickel chloride affects the reaction [chromous chloride results in decreased activity of CAT protein]
[nickel chloride results in increased abundance of Nickel] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased activity of CAT protein]; chromous chloride affects the reaction [nickel chloride results in decreased activity of CAT protein]; nickel chloride affects the reaction [chromous chloride results in decreased activity of CAT protein]
[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein; [nickel chloride results in increased abundance of Nickel] which results in decreased activity of CAT protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in decreased activity of CAT protein]; Hydroxyapatites analog inhibits the reaction [nickel chloride results in decreased activity of CAT protein]
nickel chloride results in decreased expression of CAT protein

PMID:22648416 PMID:23828460 PMID:25220231 PMID:30389395 PMID:31639282 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cystathionine beta synthase

affects expression

nickel chloride affects the expression of CBS mRNA

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

chromobox 6

decreases expression

nickel chloride results in decreased expression of CBX6 mRNA

NCBI chr 7:111,372,979...111,383,026
Ensembl chr 7:111,372,980...111,383,091

G

coiled-coil domain containing 181

affects expression

nickel chloride affects the expression of CCDC181 mRNA

NCBI chr13:76,624,567...76,638,224
Ensembl chr13:76,624,567...76,638,224

G

C-C motif chemokine ligand 1

increases secretion
multiple interactions

nickel chloride results in increased secretion of CCL1 protein
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL1 mRNA]

PMID:18437699 PMID:23090859

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 12

affects expression

nickel chloride affects the expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 2

increases expression
multiple interactions
increases secretion
decreases expression
decreases secretion

nickel chloride results in increased expression of CCL2 mRNA
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone promotes the reaction [nickel chloride results in increased expression of CCL2 mRNA]; nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
nickel chloride results in increased secretion of CCL2 protein
nickel chloride results in decreased expression of CCL2 mRNA
nickel chloride results in decreased secretion of CCL2 protein

PMID:12839937 PMID:17312168 PMID:18437699 PMID:23090859 PMID:25458486 More...

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression

nickel chloride results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

increases secretion
affects expression

nickel chloride results in increased secretion of CCL22 protein
nickel chloride affects the expression of CCL22 mRNA

PMID:18437699 PMID:24670797

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 5

increases secretion

nickel chloride results in increased secretion of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

multiple interactions
decreases secretion

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CCL7 protein; nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL7 mRNA]
nickel chloride results in decreased secretion of CCL7 protein

PMID:18437699 PMID:23090859

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 5

increases expression

nickel chloride results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

cyclin B1

affects expression

nickel chloride affects the expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression

nickel chloride results in increased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin C

affects expression

nickel chloride affects the expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions
affects expression
decreases phosphorylation
decreases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [nickel chloride results in decreased phosphorylation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein
nickel chloride affects the expression of CCND1 mRNA
CHUK protein affects the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]; nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein
nickel chloride results in decreased expression of CCND1 mRNA

PMID:17312168 PMID:18792914 PMID:22546817

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

nickel chloride results in decreased expression of CCND2 mRNA

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin E1

affects expression

nickel chloride affects the expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

decreases expression

nickel chloride results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin F

affects expression

nickel chloride affects the expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

cyclin G1

affects expression

nickel chloride affects the expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cyclin G2

multiple interactions
affects expression
increases expression

HIF1A affects the reaction [nickel chloride results in increased expression of CCNG2 mRNA]
nickel chloride affects the expression of CCNG2 mRNA

PMID:12729255 PMID:17312168 PMID:21455298 PMID:22546817

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cyclin H

affects expression

nickel chloride affects the expression of CCNH mRNA

NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819

G

cyclin J

affects expression

nickel chloride affects the expression of CCNJ mRNA

PMID:22110744 PMID:22546817

NCBI chr 1:239,659,588...239,677,367

G

C-C motif chemokine receptor 7

increases expression

nickel chloride results in increased expression of CCR7 protein

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

chaperonin containing TCP1 subunit 2

affects expression

nickel chloride affects the expression of CCT2 mRNA

NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944

G

chaperonin containing TCP1 subunit 7

affects expression

nickel chloride affects the expression of CCT7 mRNA

NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580

G

CD109 molecule

increases expression

nickel chloride results in increased expression of CD109 protein

NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194

G

CD3 gamma subunit of T-cell receptor complex

affects expression

nickel chloride affects the expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CD40 ligand

affects expression

nickel chloride affects the expression of CD40LG mRNA

NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306

G

CD44 molecule

increases expression

nickel chloride results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd80 molecule

increases expression

nickel chloride results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

increases expression
increases secretion

nickel chloride results in increased expression of CD86 mRNA; nickel chloride results in increased expression of CD86 protein
nickel chloride results in increased secretion of CD86 protein

PMID:15737199 PMID:19665512 PMID:19844976 PMID:33774146

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cell division cycle 20

affects expression

nickel chloride affects the expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 23

decreases expression

nickel chloride results in decreased expression of CDC23 mRNA

NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163

G

cell division cycle 25A

affects expression

nickel chloride affects the expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25B

affects expression

nickel chloride affects the expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

affects expression

nickel chloride affects the expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 27

affects expression

nickel chloride affects the expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 37, HSP90 cochaperone

affects expression

nickel chloride affects the expression of CDC37 mRNA

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

G

cell division cycle 37-like 1

affects expression

nickel chloride affects the expression of CDC37L1 mRNA

NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175

G

cell division cycle 7

affects expression

nickel chloride affects the expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cell division cycle associated 2

affects expression

nickel chloride affects the expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 5

affects expression

nickel chloride affects the expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cadherin 1

multiple interactions
increases methylation
decreases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased methylation of CDH1 promoter]; Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; decitabine inhibits the reaction [nickel chloride results in decreased expression of CDH1 mRNA]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]; nickel chloride promotes the reaction [SNAI2 protein binds to CDH1 promoter]
[nickel chloride results in increased abundance of Nickel] which results in decreased expression of CDH1 mRNA; [nickel chloride results in increased abundance of Nickel] which results in decreased expression of CDH1 protein; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of CDH1 protein]
nickel chloride results in decreased expression of CDH1 mRNA; nickel chloride results in decreased expression of CDH1 protein

PMID:22648416 PMID:38488660

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 17

affects expression

nickel chloride affects the expression of CDH17 mRNA

NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884

G

cadherin 2

multiple interactions

[nickel chloride results in increased abundance of Nickel] which results in increased expression of CDH2 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of CDH2 protein; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 11B

affects expression

nickel chloride affects the expression of CDK11B mRNA

NCBI chr 5:166,212,761...166,238,883
Ensembl chr 5:166,212,829...166,238,876

G

cyclin-dependent kinase 13

affects expression

nickel chloride affects the expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

cyclin-dependent kinase 20

affects expression

nickel chloride affects the expression of CDK20 mRNA

NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826

G

cyclin-dependent kinase 2 associated protein 1

affects expression

nickel chloride affects the expression of CDK2AP1 mRNA

NCBI chr12:32,249,752...32,258,483
Ensembl chr12:32,249,747...32,258,479

G

cyclin-dependent kinase 4

affects expression

nickel chloride affects the expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5

affects expression

nickel chloride affects the expression of CDK5 mRNA

NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112

G

cyclin-dependent kinase 6

affects expression

nickel chloride affects the expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase 9

affects expression

nickel chloride affects the expression of CDK9 mRNA

NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410

G

cyclin-dependent kinase inhibitor 1A

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of CDKN1A mRNA
nickel chloride affects the expression of CDKN1A mRNA
nickel chloride results in increased expression of CDKN1A mRNA; nickel chloride results in increased expression of CDKN1A protein
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1A protein]; nickel chloride promotes the reaction [TP63 mutant form results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of CDKN1A mRNA]; TP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A mRNA]; TP63 protein mutant form inhibits the reaction [nickel chloride results in increased expression of CDKN1A protein]

PMID:12426141 PMID:12839937 PMID:17547211 PMID:21466819 PMID:22546817 More...

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

affects expression
multiple interactions
increases expression

nickel chloride affects the expression of CDKN1B mRNA
HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]

PMID:22546817 PMID:28552779

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

affects expression

nickel chloride affects the expression of CDKN2A mRNA

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

cyclin-dependent kinase inhibitor 2B

affects expression

nickel chloride affects the expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cyclin-dependent kinase inhibitor 2C

affects expression

nickel chloride affects the expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

affects expression

nickel chloride affects the expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

chromatin licensing and DNA replication factor 1

affects expression

nickel chloride affects the expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

CCAAT/enhancer binding protein beta

increases expression
affects expression

nickel chloride results in increased expression of CEBPB mRNA
nickel chloride affects the expression of CEBPB mRNA

PMID:17312168 PMID:22546817

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CCAAT/enhancer binding protein delta

increases expression

nickel chloride results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

CCAAT/enhancer binding protein gamma

increases expression

nickel chloride results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

centromere protein F

affects expression

nickel chloride affects the expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

CASP8 and FADD-like apoptosis regulator

affects expression

nickel chloride affects the expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

chromodomain helicase DNA binding protein 6

affects expression

nickel chloride affects the expression of CHD6 mRNA

NCBI chr 3:149,596,509...149,757,765
Ensembl chr 3:149,596,509...149,757,755

G

chromodomain helicase DNA binding protein 7

affects expression

nickel chloride affects the expression of CHD7 mRNA

NCBI chr 5:21,812,007...21,995,358
Ensembl chr 5:21,812,070...21,995,358

G

chitinase 3 like 1

affects expression

nickel chloride affects the expression of CHI3L1 mRNA

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cholinergic receptor nicotinic delta subunit

decreases expression

nickel chloride results in decreased expression of CHRND mRNA

NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833

G

chondroitin sulfate synthase 1

affects expression

nickel chloride affects the expression of CHSY1 mRNA

NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
affects response to substance

CHUK protein affects the reaction [nickel chloride results in decreased expression of and results in increased degradation of CCND1 protein]
CHUK protein affects the susceptibility to nickel chloride

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cell death-inducing DFFA-like effector a

affects expression

nickel chloride affects the expression of CIDEA mRNA

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cell death-inducing DFFA-like effector b

affects expression

nickel chloride affects the expression of CIDEB mRNA

NCBI chr15:29,252,208...29,256,482
Ensembl chr15:29,252,213...29,256,605

G

citron rho-interacting serine/threonine kinase

affects expression

nickel chloride affects the expression of CIT mRNA

NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

increases expression

nickel chloride results in increased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

CDKN1A interacting zinc finger protein 1

affects expression

nickel chloride affects the expression of CIZ1 mRNA

NCBI chr 3:15,658,479...15,673,762
Ensembl chr 3:15,658,539...15,673,762

G

CDC28 protein kinase regulatory subunit 2

increases expression

nickel chloride results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

cardiotrophin-like cytokine factor 1

affects expression

nickel chloride affects the expression of CLCF1 mRNA

NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605

G

chloride voltage-gated channel 4

affects expression

nickel chloride affects the expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238

G

C-type lectin domain containing 5A

increases expression
affects expression

nickel chloride results in increased expression of CLEC5A protein
nickel chloride affects the expression of CLEC5A mRNA

NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859

G

CDC-like kinase 1

increases expression
affects expression

nickel chloride results in increased expression of CLK1 mRNA
nickel chloride affects the expression of CLK1 mRNA

PMID:17312168 PMID:22546817

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

CLN3 lysosomal/endosomal transmembrane protein, battenin

affects expression

nickel chloride affects the expression of CLN3 mRNA

NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434

G

CLPTM1 regulator of GABA type A receptor forward trafficking

decreases expression

nickel chloride results in decreased expression of CLPTM1 mRNA

NCBI chr 1:79,289,478...79,321,079
Ensembl chr 1:79,289,477...79,321,092

G

clarin 3

affects expression

nickel chloride affects the expression of CLRN3 mRNA

NCBI chr 1:190,319,025...190,334,648
Ensembl chr 1:190,319,026...190,334,648

G

collagen type XVIII alpha 1 chain

affects expression

nickel chloride affects the expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

multiple interactions

[nickel chloride results in increased abundance of Nickel] which results in increased expression of COL1A1 protein; Acetylcysteine inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[nickel chloride results in increased abundance of Nickel] which results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

affects expression

nickel chloride affects the expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 5

affects expression

nickel chloride affects the expression of COMMD5 mRNA

NCBI chr 7:108,621,766...108,623,616
Ensembl chr 7:108,598,673...108,624,764

G

ceruloplasmin

increases expression

nickel chloride results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1A

affects expression

nickel chloride affects the expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 3-like 1

affects expression

nickel chloride affects the expression of CREB3L1 mRNA

NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456

G

CREB3 regulatory factor

increases expression

nickel chloride results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

CRK proto-oncogene, adaptor protein

affects expression

nickel chloride affects the expression of CRK mRNA

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

cytokine receptor-like factor 2

increases expression
multiple interactions
affects expression

nickel chloride results in increased expression of CRLF2 mRNA
[nickel chloride co-treated with Freund's Adjuvant] results in increased expression of CRLF2 protein
nickel chloride affects the expression of CRLF2 mRNA

PMID:24670797 PMID:26044615

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

G

C-reactive protein

multiple interactions

[nickel chloride results in increased abundance of Nickel] which results in increased expression of CRP mRNA; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of CRP mRNA]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

crystallin, alpha B

affects expression

nickel chloride affects the expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

chromosome segregation 1 like

affects expression

nickel chloride affects the expression of CSE1L mRNA

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

colony stimulating factor 1

increases expression

nickel chloride results in increased expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 2

increases expression
affects expression

nickel chloride results in increased expression of CSF2 mRNA; nickel chloride results in increased expression of CSF2 protein
nickel chloride affects the expression of CSF2 mRNA

PMID:17312168 PMID:21569788 PMID:24670797

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression
multiple interactions

nickel chloride results in increased expression of CSF3 mRNA
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CSF3 protein; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CSF3 mRNA]

PMID:17312168 PMID:18437699 PMID:23090859

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 1, delta

decreases expression
affects expression

nickel chloride results in decreased expression of CSNK1D mRNA
nickel chloride affects the expression of CSNK1D mRNA

PMID:17312168 PMID:22546817

NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614

G

casein kinase 2 alpha 2

affects expression

nickel chloride affects the expression of CSNK2A2 mRNA

NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080

G

cysteine and serine rich nuclear protein 1

affects expression

nickel chloride affects the expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

cystatin A

affects expression

nickel chloride affects the expression of CSTA mRNA

NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488

G

cystatin B

affects expression

nickel chloride affects the expression of CSTB mRNA

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

CCCTC-binding factor

affects expression

nickel chloride affects the expression of CTCF mRNA

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

G

cystathionine gamma-lyase

increases expression
multiple interactions
decreases expression

nickel chloride results in increased expression of CTH mRNA
CTH gene mutant form promotes the reaction [nickel chloride results in increased expression of ACTA2 protein]
nickel chloride results in decreased expression of CTH mRNA; nickel chloride results in decreased expression of CTH protein
nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]; nickel chloride inhibits the reaction [SP1 protein results in increased expression of CTH protein]; sodium bisulfide inhibits the reaction [nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter]]

PMID:17312168 PMID:30055191

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin C

affects expression

nickel chloride affects the expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cullin 1

affects expression

nickel chloride affects the expression of CUL1 mRNA

NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980

G

cullin 2

affects expression

nickel chloride affects the expression of CUL2 mRNA

NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968

G

CWF19 like cell cycle control factor 1

affects expression

nickel chloride affects the expression of CWF19L1 mRNA

NCBI chr 1:242,997,720...243,020,989
Ensembl chr 1:242,997,726...243,020,961

G

CWF19 like cell cycle control factor 2

affects expression

nickel chloride affects the expression of CWF19L2 mRNA

NCBI chr 6:290,148...356,636
Ensembl chr 6:281,685...356,604

G

C-X3-C motif chemokine ligand 1

increases expression

nickel chloride results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

CXADR, Ig-like cell adhesion molecule

decreases expression

nickel chloride results in decreased expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine ligand 1

increases expression

nickel chloride results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

multiple interactions
increases expression

nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]
nickel chloride results in increased expression of CXCL10 mRNA

PMID:23090859 PMID:27427241

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

affects expression
multiple interactions

nickel chloride affects the expression of CXCL11 mRNA
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL11 mRNA]

PMID:22110744 PMID:23090859

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 12

decreases secretion

nickel chloride results in decreased secretion of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

multiple interactions

nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL13 mRNA]

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 14

decreases expression

nickel chloride results in decreased expression of CXCL14 protein

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 16

increases expression

nickel chloride results in increased expression of CXCL16 mRNA

NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592

G

C-X-C motif chemokine ligand 2

increases expression
decreases expression
multiple interactions

nickel chloride results in increased expression of CXCL2 mRNA
nickel chloride results in decreased expression of CXCL2 protein
nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL2 mRNA]

PMID:17312168 PMID:23090859 PMID:23178550

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

nickel chloride results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

increases expression

nickel chloride results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

affects expression
multiple interactions

nickel chloride affects the expression of CXCL9 mRNA
nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL9 mRNA]

PMID:22110744 PMID:23090859

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 1

increases expression

nickel chloride results in increased expression of CXCR1 protein

NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084

G

C-X-C motif chemokine receptor 3

increases expression

nickel chloride results in increased expression of CXCR3 protein

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

cytochrome c, somatic

increases expression
multiple interactions

nickel chloride results in increased expression of CYCS mRNA; nickel chloride results in increased expression of CYCS protein
Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of CYCS protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CYCS mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression
multiple interactions

nickel chloride results in decreased expression of CYP1A1 protein
nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

PMID:14645679 PMID:21784029

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases expression

nickel chloride results in decreased expression of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases expression

nickel chloride results in decreased expression of CYP1B1 mRNA

PMID:12839937 PMID:14645679

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 27, subfamily a, polypeptide 1

affects expression

nickel chloride affects the expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

DAB adaptor protein 2

decreases expression

nickel chloride results in decreased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dachshund family transcription factor 1

decreases expression

nickel chloride results in decreased expression of DACH1 mRNA

NCBI chr15:74,528,122...74,909,811
Ensembl chr15:74,529,208...74,909,922

G

defender against cell death 1

affects expression

nickel chloride affects the expression of DAD1 mRNA

NCBI chr15:27,677,286...27,697,120
Ensembl chr15:27,677,268...27,697,347

G

death-associated protein

affects expression

nickel chloride affects the expression of DAP mRNA

NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752

G

death associated protein 3

affects expression

nickel chloride affects the expression of DAP3 mRNA

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

G

death associated protein-like 1

affects expression

nickel chloride affects the expression of DAPL1 mRNA

NCBI chr 3:43,960,993...43,980,940
Ensembl chr 3:43,960,810...43,980,940

G

death-domain associated protein

affects expression

nickel chloride affects the expression of DAXX mRNA

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

diazepam binding inhibitor

affects expression

nickel chloride affects the expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

G

dicarbonyl and L-xylulose reductase

affects expression

nickel chloride affects the expression of DCXR mRNA

NCBI chr10:106,006,404...106,008,293

G

DNA-damage inducible transcript 3

increases expression
affects expression

nickel chloride results in increased expression of DDIT3 mRNA
nickel chloride affects the expression of DDIT3 mRNA

PMID:12426141 PMID:12839937 PMID:22546817

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression
affects expression

nickel chloride results in increased expression of DDIT4 mRNA
nickel chloride affects the expression of DDIT4 mRNA

PMID:17312168 PMID:22110744 PMID:22546817

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DEAD-box helicase 17

decreases expression

nickel chloride results in decreased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

delta(4)-desaturase, sphingolipid 1

decreases expression

nickel chloride results in decreased expression of DEGS1 mRNA

NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664

G

DEP domain containing 7

affects expression

nickel chloride affects the expression of DEPDC7 mRNA

NCBI chr 3:91,099,111...91,121,152
Ensembl chr 3:91,099,835...91,121,124

G

DEP domain containing MTOR-interacting protein

affects expression

nickel chloride affects the expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

24-dehydrocholesterol reductase

affects expression
decreases expression

nickel chloride affects the expression of DHCR24 mRNA
nickel chloride results in decreased expression of DHCR24 mRNA

PMID:17312168 PMID:22110744

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dihydroorotate dehydrogenase

affects expression

nickel chloride affects the expression of DHODH mRNA

NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654

G

dicer 1 ribonuclease III

decreases expression

nickel chloride results in decreased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

divergent protein kinase domain 2A

affects expression

nickel chloride affects the expression of DIPK2A mRNA

NCBI chr 8:95,070,695...95,089,815
Ensembl chr 8:95,030,279...95,089,815

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

nickel chloride results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

discs large MAGUK scaffold protein 5

affects expression

nickel chloride affects the expression of DLG5 mRNA

NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837

G

DLG associated protein 5

affects expression

nickel chloride affects the expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

DnaJ heat shock protein family (Hsp40) member B13

increases expression
affects expression

nickel chloride results in increased expression of DNAJB13 mRNA
nickel chloride affects the expression of DNAJB13 mRNA

PMID:21455298 PMID:22546817

NCBI chr 1:154,848,586...154,863,042
Ensembl chr 1:154,848,594...154,862,963

G

DnaJ heat shock protein family (Hsp40) member B4

decreases expression

nickel chloride results in decreased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression

nickel chloride results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

nickel chloride results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

deoxyribonuclease 1

affects expression

nickel chloride affects the expression of DNASE1 mRNA

NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869

G

deoxyribonuclease 1L3

affects expression

nickel chloride affects the expression of DNASE1L3 mRNA

NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317

G

deoxyribonuclease 2, lysosomal

affects expression

nickel chloride affects the expression of DNASE2 mRNA

NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376

G

dynamin 1-like

multiple interactions
increases expression

[nickel chloride results in increased abundance of Nickel] which results in increased expression of DNM1L mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of DNM1L protein
nickel chloride results in increased expression of DNM1L mRNA; nickel chloride results in increased expression of DNM1L protein

PMID:36794572 PMID:38552765

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dynamin 2

affects expression

nickel chloride affects the expression of DNM2 mRNA

NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157

G

dipeptidylpeptidase 7

affects expression

nickel chloride affects the expression of DPP7 mRNA

NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355

G

dystonin

affects expression

nickel chloride affects the expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

dual serine/threonine and tyrosine protein kinase

affects expression

nickel chloride affects the expression of DSTYK mRNA

NCBI chr13:43,857,266...43,905,280
Ensembl chr13:43,857,266...43,905,269

G

deoxythymidylate kinase

affects expression

nickel chloride affects the expression of DTYMK mRNA

NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870

G

dual specificity phosphatase 1

increases expression
affects expression

nickel chloride results in increased expression of DUSP1 mRNA
nickel chloride affects the expression of DUSP1 mRNA

PMID:17547211 PMID:22110744 PMID:22546817

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

increases expression

nickel chloride results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

DAZ interacting zinc finger protein 1

decreases expression

nickel chloride results in decreased expression of DZIP1 mRNA

NCBI chr15:95,956,329...96,009,994
Ensembl chr15:95,956,398...96,010,066

G

E2F transcription factor 1

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of E2F1 mRNA
nickel chloride affects the expression of E2F1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]

PMID:12729255 PMID:22546817

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

ELL associated factor 2

affects expression

nickel chloride affects the expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

Epstein-Barr virus induced 3

increases expression

nickel chloride results in increased expression of EBI3 mRNA

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

EDAR associated via death domain

multiple interactions

nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDARADD mRNA]

NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447

G

ER degradation enhancing alpha-mannosidase like protein 3

decreases expression

nickel chloride results in decreased expression of EDEM3 mRNA

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

G

endothelin 2

increases expression

nickel chloride results in increased expression of EDN2 mRNA

NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814

G

eukaryotic translation elongation factor 2

increases expression

nickel chloride results in increased expression of EEF2 mRNA

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

EEIG family member 2

affects expression

nickel chloride affects the expression of EEIG2 mRNA

NCBI chr 2:196,608,499...196,663,371
Ensembl chr 2:196,608,499...196,663,371

G

EGF containing fibulin extracellular matrix protein 2

increases expression

nickel chloride results in increased expression of EFEMP2 mRNA

NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414

G

ephrin A1

increases expression

nickel chloride results in increased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

epidermal growth factor

multiple interactions

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of EGF protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

affects expression
multiple interactions
increases expression

nickel chloride affects the expression of EGFR mRNA
RECK protein inhibits the reaction [nickel chloride results in increased expression of EGFR protein]

PMID:22546817 PMID:26026961

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

decreases activity
increases expression
affects expression
multiple interactions

nickel chloride results in decreased activity of EGLN1 protein
nickel chloride results in increased expression of EGLN1 mRNA
nickel chloride affects the expression of EGLN1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]

PMID:12729255 PMID:12839937 PMID:16649251 PMID:17312168 PMID:22110744

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

egl-9 family hypoxia-inducible factor 3

increases expression
affects expression

nickel chloride results in increased expression of EGLN3 mRNA
nickel chloride affects the expression of EGLN3 mRNA

PMID:21455298 PMID:22110744 PMID:22546817

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

increases expression

nickel chloride results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EP300 interacting inhibitor of differentiation 1

decreases expression

nickel chloride results in decreased expression of EID1 mRNA

NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

nickel chloride results in decreased expression of EIF1AX mRNA

NCBI chr X:35,498,698...35,513,402
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 4E family member 3

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA

NCBI chr 4:132,258,502...132,301,808
Ensembl chr 4:132,258,502...132,301,808

G

ETS transcription factor ELK1

affects expression

nickel chloride affects the expression of ELK1 mRNA

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

ELOVL fatty acid elongase 6

affects expression

nickel chloride affects the expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

epithelial membrane protein 1

affects expression

nickel chloride affects the expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

ectodermal-neural cortex 1

affects expression

nickel chloride affects the expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

enolase 2

increases expression

nickel chloride results in increased expression of ENO2 mRNA

PMID:17312168 PMID:21455298

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleoside triphosphate diphosphohydrolase 4

decreases expression

nickel chloride results in decreased expression of ENTPD4 mRNA

NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706

G

erythropoietin receptor

affects expression

nickel chloride affects the expression of EPOR mRNA

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

Era-like 12S mitochondrial rRNA chaperone 1

affects expression

nickel chloride affects the expression of ERAL1 mRNA

NCBI chr10:62,961,725...62,968,747
Ensembl chr10:62,961,730...62,968,994

G

erb-b2 receptor tyrosine kinase 3

affects expression

nickel chloride affects the expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

endoplasmic reticulum oxidoreductase 1 alpha

affects expression
increases expression
multiple interactions

nickel chloride affects the expression of ERO1A mRNA
nickel chloride results in increased expression of ERO1A mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of ERO1A mRNA]

PMID:12729255 PMID:22110744

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

G

ERBB receptor feedback inhibitor 1

affects expression

nickel chloride affects the expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

extra spindle pole bodies like 1, separase

affects expression

nickel chloride affects the expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

estrogen receptor 1

affects response to substance
decreases expression
multiple interactions

ESR1 protein affects the susceptibility to nickel chloride
nickel chloride results in decreased expression of ESR1 mRNA; nickel chloride results in decreased expression of ESR1 protein
nickel chloride binds to and results in increased activity of ESR1 protein; nickel chloride inhibits the reaction [Estradiol binds to ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

F2R like trypsin receptor 1

increases expression

nickel chloride results in increased expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

coagulation factor V

decreases expression

nickel chloride results in decreased expression of F5 mRNA

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

fatty acid binding protein 1

affects expression

nickel chloride affects the expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

Fas apoptotic inhibitory molecule

affects expression

nickel chloride affects the expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 120 member C

affects expression

nickel chloride affects the expression of FAM120C mRNA

NCBI chr X:20,324,046...20,477,831
Ensembl chr X:20,323,381...20,477,275

G

family with sequence similarity 13, member A

increases expression

nickel chloride results in increased expression of FAM13A mRNA

NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860

G

FA complementation group D2

decreases expression

nickel chloride results in decreased expression of FANCD2 mRNA; nickel chloride results in decreased expression of FANCD2 protein

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group L

decreases expression

nickel chloride results in decreased expression of FANCL mRNA

NCBI chr14:100,249,733...100,317,958
Ensembl chr14:100,248,875...100,314,255

G

Fas cell surface death receptor

affects expression

nickel chloride affects the expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

affects expression
decreases expression

nickel chloride affects the expression of FASN mRNA
nickel chloride results in decreased expression of FASN mRNA

PMID:17312168 PMID:22110744

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibulin 5

affects expression

nickel chloride affects the expression of FBLN5 mRNA

NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755

G

F-box protein 2

affects expression

nickel chloride affects the expression of FBXO2 mRNA

NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355

G

F-box protein 30

affects expression

nickel chloride affects the expression of FBXO30 mRNA

NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441

G

F-box protein 32

increases expression

nickel chloride results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

F-box and WD repeat domain containing 2

decreases expression

nickel chloride results in decreased expression of FBXW2 mRNA

PMID:17312168 PMID:17547211

NCBI chr 3:18,088,859...18,114,387
Ensembl chr 3:18,088,865...18,114,381

G

farnesyl diphosphate synthase

decreases expression

nickel chloride results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

fem-1 homolog B

decreases expression
affects expression

nickel chloride results in decreased expression of FEM1B mRNA
nickel chloride affects the expression of FEM1B mRNA

PMID:17312168 PMID:22546817

NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577

G

fibroblast growth factor 1

affects expression

nickel chloride affects the expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 11

increases expression

nickel chloride results in increased expression of FGF11 mRNA

NCBI chr10:54,516,508...54,522,067
Ensembl chr10:54,517,077...54,522,062

G

fibroblast growth factor 2

affects expression

nickel chloride affects the expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor binding protein 3

affects expression

nickel chloride affects the expression of FGFBP3 mRNA

NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547

G

FGR proto-oncogene, Src family tyrosine kinase

affects expression

nickel chloride affects the expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

fragile histidine triad diadenosine triphosphatase

decreases expression

nickel chloride results in decreased expression of FHIT protein

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

fission, mitochondrial 1

affects expression
increases expression
multiple interactions

nickel chloride affects the expression of FIS1 mRNA
nickel chloride results in increased expression of FIS1 mRNA; nickel chloride results in increased expression of FIS1 protein
[nickel chloride results in increased abundance of Nickel] which results in increased expression of FIS1 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of FIS1 protein

PMID:22546817 PMID:36794572 PMID:38552765

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

FKBP prolyl isomerase 11

affects expression

nickel chloride affects the expression of FKBP11 mRNA

NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303

G

flotillin 1

affects expression

nickel chloride affects the expression of FLOT1 mRNA

NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978

G

fibronectin leucine rich transmembrane protein 2

increases expression

nickel chloride results in increased expression of FLRT2 mRNA

NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785

G

fibronectin 1

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; sodium bisulfide inhibits the reaction [nickel chloride results in increased expression of FN1 mRNA]
nickel chloride results in increased expression of FN1 mRNA; nickel chloride results in increased expression of FN1 protein

PMID:22648416 PMID:30055191

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fructosamine 3 kinase

increases expression

nickel chloride results in increased expression of FN3K mRNA

NCBI chr10:106,700,670...106,715,903
Ensembl chr10:106,700,670...106,715,895

G

formin binding protein 1

increases expression

nickel chloride results in increased expression of FNBP1 mRNA

NCBI chr 3:14,309,067...14,424,378
Ensembl chr 3:14,309,640...14,424,881

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

nickel chloride results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of FOSB protein

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

nickel chloride results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

FOS like 2, AP-1 transcription factor subunit

increases expression

nickel chloride results in increased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box O3

increases expression
affects expression

nickel chloride results in increased expression of FOXO3 mRNA
nickel chloride affects the expression of FOXO3 mRNA

PMID:17312168 PMID:22546817

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box Q1

affects expression

nickel chloride affects the expression of FOXQ1 mRNA

NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377

G

fucose-1-phosphate guanylyltransferase

decreases expression

nickel chloride results in decreased expression of FPGT mRNA

NCBI chr 2:244,099,031...244,119,967
Ensembl chr 2:244,099,076...244,119,899

G

follistatin like 3

affects expression

nickel chloride affects the expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

ferritin heavy chain 1

decreases expression

nickel chloride results in decreased expression of FTH1 mRNA; nickel chloride results in decreased expression of FTH1 protein

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

multiple interactions

[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

FUN14 domain containing 1

multiple interactions

[nickel chloride results in increased abundance of Nickel] which results in increased expression of FUNDC1 mRNA; [nickel chloride results in increased abundance of Nickel] which results in increased expression of FUNDC1 protein

NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284

G

furin (paired basic amino acid cleaving enzyme)

decreases expression

nickel chloride results in decreased expression of FURIN mRNA

NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314

G

fucosyltransferase 8

increases expression

nickel chloride results in increased expression of FUT8 mRNA

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

fizzy and cell division cycle 20 related 1

affects expression

nickel chloride affects the expression of FZR1 mRNA

NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952

G

glucose-6-phosphatase catalytic subunit 1

affects expression

nickel chloride affects the expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

increases expression
affects expression

nickel chloride results in increased expression of G6PDX mRNA
nickel chloride affects the expression of G6PD mRNA

PMID:12426141 PMID:22546817

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of GADD45A mRNA
nickel chloride affects the expression of GADD45A mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in increased expression of PPP2CA protein; nickel chloride results in increased expression of GADD45A mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of FOSB protein; [nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of and results in decreased expression of JUN protein; [nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of ATF2 protein; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K3 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K6 protein]; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K7 protein]; nickel chloride results in increased stability of and results in increased expression of GADD45A protein

PMID:12839937 PMID:22546817 PMID:23536762 PMID:23566959

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

affects expression

nickel chloride affects the expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

growth arrest and DNA-damage-inducible, gamma

affects expression

nickel chloride affects the expression of GADD45G mRNA

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

G

cyclin G associated kinase

affects expression

nickel chloride affects the expression of GAK mRNA

NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398

G

polypeptide N-acetylgalactosaminyltransferase 11

decreases expression

nickel chloride results in decreased expression of GALNT11 mRNA

NCBI chr 4:9,837,629...9,871,141
Ensembl chr 4:9,837,629...9,871,140

G

polypeptide N-acetylgalactosaminyltransferase 2

decreases expression

nickel chloride results in decreased expression of GALNT2 mRNA

NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression
affects expression
multiple interactions

nickel chloride results in increased expression of GAPDH mRNA
nickel chloride affects the expression of GAPDH mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]

PMID:10646848 PMID:12426141 PMID:12839937 PMID:22546817 PMID:23566959

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest-specific 1

decreases expression

nickel chloride results in decreased expression of GAS1 mRNA

NCBI chr17:4,482,168...4,485,153

G

growth arrest-specific 2

affects expression

nickel chloride affects the expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619

G

GATA binding protein 6

increases expression

nickel chloride results in increased expression of GATA6 mRNA

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

1,4-alpha-glucan branching enzyme 1

affects expression
increases expression
multiple interactions

nickel chloride affects the expression of GBE1 mRNA
nickel chloride results in increased expression of GBE1 mRNA
HIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]

PMID:15094311 PMID:22110744

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein 1

increases expression

nickel chloride results in increased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glycine C-acetyltransferase

affects expression

nickel chloride affects the expression of GCAT mRNA

NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473

G

GTP cyclohydrolase 1

affects expression

nickel chloride affects the expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glutamate-cysteine ligase, catalytic subunit

affects expression
increases expression

nickel chloride affects the expression of GCLC mRNA
nickel chloride results in increased expression of GCLC mRNA

PMID:17547211 PMID:21111804 PMID:22110744

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

nickel chloride results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

nickel chloride results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

glycerophosphodiester phosphodiesterase 1

affects expression

nickel chloride affects the expression of GDE1 mRNA

NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429

G

growth differentiation factor 15

increases expression

nickel chloride results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 5

affects expression

nickel chloride affects the expression of GDF5 mRNA

NCBI chr 3:144,454,316...144,458,508
Ensembl chr 3:144,454,338...144,458,612

G

gem (nuclear organelle) associated protein 4

decreases expression

nickel chloride results in decreased expression of GEMIN4 mRNA

NCBI chr10:61,062,420...61,073,529
Ensembl chr10:61,066,425...61,073,431
Ensembl chr10:61,066,425...61,073,431

G

gamma-glutamyl carboxylase

decreases expression

nickel chloride results in decreased expression of GGCX mRNA

NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063

G

gap junction protein, beta 1

affects expression

nickel chloride affects the expression of GJB1 mRNA

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

galactosidase, alpha

increases expression

nickel chloride results in increased expression of GLA mRNA

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

glutaredoxin

increases expression
affects expression

nickel chloride results in increased expression of GLRX mRNA
nickel chloride affects the expression of GLRX mRNA

PMID:17547211 PMID:22110744

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

geminin, DNA replication inhibitor

affects expression

nickel chloride affects the expression of GMNN mRNA

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

G

G protein subunit alpha q

affects expression

nickel chloride affects the expression of GNAQ mRNA

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

glycerol-3-phosphate acyltransferase 3

affects expression

nickel chloride affects the expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

G protein-coupled estrogen receptor 1

decreases expression

nickel chloride results in decreased expression of GPER1 mRNA

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

glucose-6-phosphate isomerase

increases expression
multiple interactions

nickel chloride results in increased expression of GPI1 mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GPI1 mRNA]

PMID:12426141 PMID:12729255 PMID:12839937

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

G protein-coupled receptor 137B

increases expression
multiple interactions

nickel chloride results in increased expression of GPR137B mRNA
HIF1A affects the reaction [nickel chloride results in increased expression of GPR137B mRNA]

NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835

G

G protein-coupled receptor 146

affects expression

nickel chloride affects the expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of GPT protein; [nickel chloride results in increased abundance of Nickel] which results in increased activity of GPT protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of GPT protein]
nickel chloride results in increased activity of GPT protein

PMID:31639282 PMID:34921910

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

affects expression

nickel chloride affects the expression of GPX1 mRNA

PMID:22110744 PMID:22546817

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

decreases expression

nickel chloride results in decreased expression of GPX4 mRNA; nickel chloride results in decreased expression of GPX4 protein

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

growth factor receptor bound protein 14

affects expression

nickel chloride affects the expression of GRB14 mRNA

NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889

G

granulin precursor

affects expression

nickel chloride affects the expression of GRN mRNA

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 beta

multiple interactions
affects expression

[nickel chloride results in increased phosphorylation of AKT1 protein] which results in decreased activity of and results in increased phosphorylation of GSK3B protein; nickel chloride promotes the reaction [Tretinoin results in increased phosphorylation of GSK3B protein]
nickel chloride affects the expression of GSK3B mRNA

PMID:21837363 PMID:22546817 PMID:25614230

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase mu 2

decreases expression
increases methylation
multiple interactions

nickel chloride results in decreased expression of GSTM2 mRNA
nickel chloride results in increased methylation of GSTM2 promoter
nickel chloride results in decreased expression of GSTM2 mRNA; nickel chloride results in decreased expression of GSTM2 protein
[nickel chloride co-treated with Metformin] promotes the reaction [SP1 protein binds to GSTM2 promoter]; Decitabine inhibits the reaction [nickel chloride results in decreased expression of GSTM2 mRNA]; Metformin inhibits the reaction [nickel chloride results in decreased expression of GSTM2 mRNA]; trichostatin A inhibits the reaction [nickel chloride results in decreased expression of GSTM2 mRNA]

PMID:14645679 PMID:38050843

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase theta 1

decreases expression

nickel chloride results in decreased expression of GSTT1 mRNA

PMID:12729255 PMID:14645679

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

glucuronidase, beta

affects expression
increases activity

nickel chloride affects the expression of GUSB mRNA
nickel chloride results in increased activity of GUSB protein

PMID:12028813 PMID:22110744

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

glycogen synthase 1

affects expression

nickel chloride affects the expression of GYS1 mRNA

NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292

G

H2A.X variant histone

decreases expression
increases expression
increases phosphorylation
multiple interactions

nickel chloride results in decreased expression of H2AX mRNA
nickel chloride results in increased expression of H2AX protein modified form
nickel chloride results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]; nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AX protein]

PMID:17312168 PMID:22172632 PMID:28552779

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H2B.U histone 1

decreases acetylation
increases ubiquitination

nickel chloride results in decreased acetylation of H2BC26 protein
nickel chloride results in increased ubiquitination of H2BC26 protein

NCBI chr10:43,732,737...43,733,484
Ensembl chr10:43,732,864...43,736,277

G

H3.4 histone, cluster member

decreases acetylation
increases methylation

nickel chloride results in decreased acetylation of H3-4 protein
nickel chloride results in increased methylation of H3-4 protein

PMID:16522665 PMID:19371620

NCBI chr10:43,740,702...43,741,262

G

hydroxyacyl-CoA dehydrogenase

affects expression

nickel chloride affects the expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hydroxyacid oxidase 1

decreases expression

nickel chloride results in decreased expression of HAO1 mRNA

NCBI chr 3:121,757,400...121,828,721
Ensembl chr 3:121,771,836...121,828,721

G

HAUS augmin-like complex, subunit 1

affects expression

nickel chloride affects the expression of HAUS1 mRNA

NCBI chr18:71,275,417...71,286,626
Ensembl chr18:71,273,537...71,286,660

G

host cell factor C2

affects expression

nickel chloride affects the expression of HCFC2 mRNA

NCBI chr 7:20,983,986...21,019,826
Ensembl chr 7:20,991,017...21,019,801

G

histone deacetylase 3

affects expression

nickel chloride affects the expression of HDAC3 mRNA

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

histone deacetylase 7

affects expression

nickel chloride affects the expression of HDAC7 mRNA

NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072

G

histidine decarboxylase

affects expression

nickel chloride affects the expression of HDC mRNA

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

hexosaminidase subunit beta

affects expression

nickel chloride affects the expression of HEXB mRNA

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression
increases stability
affects response to substance

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of HIF1A protein]; [nickel chloride co-treated with Tretinoin] results in increased expression of HIF1A protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of and results in decreased hydroxylation of HIF1A protein; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]; Cycloheximide promotes the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein]; HIF1A mutant form inhibits the reaction [nickel chloride results in increased expression of FN1 protein]; HIF1A protein affects the reaction [nickel chloride results in increased secretion of IL6 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of BNIP3 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CA9 protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1A protein]; HIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]; nickel chloride inhibits the reaction [HIF1A protein binds to HSP90AB1 protein]; nickel chloride inhibits the reaction [VHL protein binds to HIF1A protein]; nickel chloride promotes the reaction [HIF1A protein binds to ARNT protein]; nickel chloride promotes the reaction [HIF1A protein binds to CDH1 promoter]; nickel chloride results in increased expression of and affects the localization of HIF1A protein; nickel chloride results in increased expression of and results in increased activity of HIF1A protein; nickel chloride results in increased expression of and results in increased stability of HIF1A protein; nickel chloride results in increased stability of and affects the localization of HIF1A protein; nickel chloride results in increased stability of and results in increased expression of HIF1A protein; Rotenone inhibits the reaction [nickel chloride results in increased expression of HIF1A protein]
nickel chloride results in increased stability of HIF1A protein
AKT1 protein affects the reaction [nickel chloride results in increased expression of HIF1A protein]; HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ALDOA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ARNT mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of BNIP3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of CCNG2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of E2F1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of EGLN1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of ERO1A mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPI1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of GPR137B mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of HK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of IER3 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of P4HA2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PFKL mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PGK1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PKM mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of PTK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of SLC2A1 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of TPI1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GAPDH mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of GBE1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]
HIF1A protein affects the susceptibility to nickel chloride

PMID:10646848 PMID:12426141 PMID:12729255 PMID:12839937 PMID:14729612 More...

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 1 subunit alpha inhibitor

decreases expression

nickel chloride results in decreased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

HIG1 hypoxia inducible domain family, member 1A

affects expression
increases expression

nickel chloride affects the expression of HIGD1A mRNA
nickel chloride results in increased expression of HIGD1A mRNA

PMID:12839937 PMID:22110744

NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443

G

hypoxia inducible lipid droplet-associated

increases expression

nickel chloride results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

huntingtin interacting protein 1

affects expression

nickel chloride affects the expression of HIP1 mRNA

PMID:22110744 PMID:22546817

NCBI chr12:21,133,364...21,267,796
Ensembl chr12:21,133,406...21,267,725

G

homeodomain interacting protein kinase 1

affects expression

nickel chloride affects the expression of HIPK1 mRNA

NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902

G

HIVEP zinc finger 2

increases expression

nickel chloride results in increased expression of HIVEP2 mRNA

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

hexokinase 1

increases expression

nickel chloride results in increased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

increases expression
multiple interactions

nickel chloride results in increased expression of HK2 mRNA; nickel chloride results in increased expression of HK2 protein
2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [nickel chloride results in increased expression of HK2 mRNA]
Dinoprostone promotes the reaction [nickel chloride results in increased expression of HK2 mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of HK2 mRNA]

PMID:12426141 PMID:12729255 PMID:12839937 PMID:21455298 PMID:23566959 More...

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

nickel chloride results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

affects expression

nickel chloride affects the expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

high mobility group nucleosome binding domain 5

affects expression

nickel chloride affects the expression of HMGN5 mRNA

NCBI chr X:74,085,871...74,094,488
Ensembl chr X:74,085,875...74,094,441
Ensembl chr 1:74,085,875...74,094,441

G

heme oxygenase 1

multiple interactions
affects expression
increases expression

Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of HMOX1 mRNA]; nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of HMOX1 protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of HMOX1 mRNA]
nickel chloride affects the expression of HMOX1 mRNA

PMID:16806455 PMID:17312168 PMID:17547211 PMID:18830972 PMID:21111804 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

harakiri, BCL2 interacting protein

affects expression

nickel chloride affects the expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

hydroxysteroid (17-beta) dehydrogenase 13

affects expression

nickel chloride affects the expression of HSD17B13 mRNA

NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166

G

heat shock protein 90 alpha family class B member 1

multiple interactions

nickel chloride inhibits the reaction [HIF1A protein binds to HSP90AB1 protein]

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

decreases expression
increases expression

nickel chloride results in decreased expression of HSPA1A mRNA
nickel chloride results in increased expression of HSPA1A mRNA

PMID:12426141 PMID:12839937 PMID:17312168

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

decreases expression

nickel chloride results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

nickel chloride results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

decreases expression
increases expression

nickel chloride results in decreased expression of HSPA8 mRNA
nickel chloride results in increased expression of HSPA8 protein

PMID:15736156 PMID:17312168

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

affects expression

nickel chloride affects the expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 8

affects expression

nickel chloride affects the expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

intercellular adhesion molecule 1

increases expression
multiple interactions
increases secretion

nickel chloride results in increased expression of ICAM1 mRNA; nickel chloride results in increased expression of ICAM1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; [nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]
nickel chloride results in increased secretion of ICAM1 protein

PMID:15737199 PMID:17312168 PMID:19844976 PMID:24080332 PMID:33774146

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

affects expression

nickel chloride affects the expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

isocitrate dehydrogenase (NADP(+)) 2

increases activity

nickel chloride results in increased activity of IDH2 protein

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

affects expression

nickel chloride affects the expression of IDH3B mRNA

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

G

immediate early response 2

increases expression

nickel chloride results in increased expression of IER2 mRNA

NCBI chr19:23,494,551...23,496,075
Ensembl chr19:23,494,184...23,499,211

G

immediate early response 3

multiple interactions
affects expression
increases expression

HIF1A affects the reaction [nickel chloride results in increased expression of IER3 mRNA]
nickel chloride affects the expression of IER3 mRNA

PMID:12729255 PMID:22110744

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon, alpha-inducible protein 27

multiple interactions
increases expression

Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA]

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 44-like

increases expression

nickel chloride results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

increases expression

nickel chloride results in increased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon induced transmembrane protein 1

affects expression
multiple interactions

nickel chloride affects the expression of IFITM1 mRNA
[nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA

PMID:22546817 PMID:37951547

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon induced transmembrane protein 3

affects expression

nickel chloride affects the expression of IFITM3 mRNA

NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203

G

interferon gamma

multiple interactions

nickel chloride inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IFNG promoter]
[MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IFNG protein; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]

PMID:8975779 PMID:21544193 PMID:21569788

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

nickel chloride results in increased expression of IFNGR1 mRNA

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

interferon gamma receptor 2

increases expression

nickel chloride results in increased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

interferon-related developmental regulator 1

affects expression

nickel chloride affects the expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1

multiple interactions

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

affects expression

nickel chloride affects the expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 1

increases expression

nickel chloride results in increased expression of IGFBP1 mRNA

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

insulin-like growth factor binding protein 3

increases expression

nickel chloride results in increased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 4

decreases expression

nickel chloride results in decreased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein-like 1

affects expression

nickel chloride affects the expression of IGFBPL1 mRNA

NCBI chr 5:60,076,428...60,091,833
Ensembl chr 5:60,076,429...60,091,833

G

immunoglobulin superfamily, member 1

decreases expression

nickel chloride results in decreased expression of IGSF1 mRNA

NCBI chr X:129,069,891...129,085,331
Ensembl chr X:129,069,896...129,085,139

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects response to substance
increases phosphorylation
multiple interactions

IKBKB affects the susceptibility to nickel chloride
nickel chloride results in increased phosphorylation of IKBKB protein
chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; IKBKB gene mutant form inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]; Quercetin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]; SC 514 inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein]
IKBKB affects the reaction [nickel chloride results in increased activity of PTGS2 promoter]

PMID:16982623 PMID:21466819 PMID:30016632

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

decreases expression

nickel chloride results in decreased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

interleukin 10

affects expression
multiple interactions
increases expression

nickel chloride affects the expression of IL10 mRNA
Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
nickel chloride results in increased expression of IL10 mRNA; nickel chloride results in increased expression of IL10 protein
[MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IL10 protein

PMID:21544193 PMID:22546817 PMID:27427241 PMID:30016632

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

affects expression

nickel chloride affects the expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 15

multiple interactions

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 18

affects expression

nickel chloride affects the expression of IL18 mRNA

PMID:22546817 PMID:24670797

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 receptor 1

increases expression

nickel chloride results in increased expression of IL18R1 mRNA

NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715

G

interleukin 1 alpha

increases expression
decreases expression
multiple interactions

nickel chloride results in increased expression of IL1A mRNA
nickel chloride results in decreased expression of IL1A protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1A protein

PMID:11378323 PMID:17312168 PMID:18437699 PMID:23178550

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
affects expression
decreases expression
increases secretion

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; CASP1 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; PYCARD protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL1B mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL1B mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL1B protein]
nickel chloride results in increased expression of IL1B mRNA; nickel chloride results in increased expression of IL1B protein
nickel chloride affects the expression of IL1B mRNA
[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of IL1B protein]
nickel chloride results in decreased expression of IL1B mRNA
nickel chloride results in increased secretion of IL1B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased cleavage of CASP1 protein] which results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein; [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein; [Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; MitoTEMPO inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL1B protein]; Sodium inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with nickel chloride] results in increased secretion of IL1B protein]

PMID:11378323 PMID:16687389 PMID:18437699 PMID:19844976 PMID:21569788 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions
increases expression

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL2 protein; nickel chloride inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IL2 promoter]
Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL2 mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL2 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL2 protein]
nickel chloride results in increased expression of IL2 mRNA; nickel chloride results in increased expression of IL2 protein

PMID:18437699 PMID:21569788 PMID:36421005

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 27

increases expression

nickel chloride results in increased expression of IL27 mRNA

NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582

G

interleukin 36, beta

multiple interactions

nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL36B mRNA]

NCBI chr 3:7,024,881...7,030,388
Ensembl chr 3:7,021,973...7,031,619

G

interleukin 4

multiple interactions

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

increases secretion
multiple interactions

nickel chloride results in increased secretion of IL5 protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL5 protein

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions
increases expression
decreases expression
increases secretion
decreases secretion

Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL6 mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL6 mRNA]
nickel chloride results in decreased expression of IL6 mRNA
nickel chloride results in increased secretion of IL6 protein
nickel chloride results in increased expression of IL6 mRNA; nickel chloride results in increased expression of IL6 protein
nickel chloride results in decreased secretion of IL6 protein
[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL6 mRNA; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; HIF1A protein affects the reaction [nickel chloride results in increased secretion of IL6 protein]; Luteolin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; nickel chloride promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of IL6 mRNA]

PMID:11378323 PMID:16687389 PMID:17312168 PMID:18437699 PMID:23090859 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

increases expression
multiple interactions

nickel chloride results in increased expression of IL7 mRNA
Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of IL7 mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of IL7 mRNA]

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

ILK associated serine/threonine phosphatase

affects expression

nickel chloride affects the expression of ILKAP mRNA

NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892

G

inhibin subunit beta A

increases expression

nickel chloride results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

inositol polyphosphate-5-phosphatase D

affects expression

nickel chloride affects the expression of INPP5D mRNA

NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746

G

insulin 1

multiple interactions

nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

IQ motif and Sec7 domain ArfGEF 1

increases expression

nickel chloride results in increased expression of IQSEC1 mRNA

NCBI chr 4:123,168,719...123,488,300
Ensembl chr 4:123,168,719...123,488,172

G

interleukin-1 receptor-associated kinase 4

increases expression

nickel chloride results in increased expression of IRAK4 protein

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

G

interferon regulatory factor 2

increases expression

nickel chloride results in increased expression of IRF2 mRNA

NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024

G

interferon regulatory factor 3

decreases expression
multiple interactions

nickel chloride results in decreased expression of IRF3 mRNA
IRF3 protein inhibits the reaction [nickel chloride results in decreased expression of TP63 mRNA alternative form]

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

interferon regulatory factor 6

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA

NCBI chr13:104,672,179...104,691,386
Ensembl chr13:104,672,179...104,691,386

G

interferon regulatory factor 7

decreases expression

nickel chloride results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

interferon regulatory factor 8

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

iron-sulfur cluster assembly enzyme

decreases activity

nickel chloride results in decreased activity of ISCU protein

NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150

G

ISG15 ubiquitin-like modifier

affects expression

nickel chloride affects the expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit beta 3 binding protein

increases expression

nickel chloride results in increased expression of ITGB3BP mRNA

NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704

G

integrin subunit beta 8

increases expression

nickel chloride results in increased expression of ITGB8 mRNA

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

integral membrane protein 2B

affects expression

nickel chloride affects the expression of ITM2B mRNA

NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917

G

jagged canonical Notch ligand 1

increases expression

nickel chloride results in increased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 2

affects expression

nickel chloride affects the expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression
affects expression

nickel chloride results in increased expression of JMJD6 mRNA
nickel chloride affects the expression of JMJD6 mRNA

PMID:22110744 PMID:22546817

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression
multiple interactions

nickel chloride affects the expression of JUN mRNA
[nickel chloride results in increased expression of GADD45A protein] which results in decreased phosphorylation of and results in decreased expression of JUN protein

PMID:22110744 PMID:23536762

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

nickel chloride results in increased expression of JUNB mRNA

PMID:12426141 PMID:12839937 PMID:17312168

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

JunD proto-oncogene, AP-1 transcription factor subunit

affects expression

nickel chloride affects the expression of JUND mRNA

NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799

G

KN motif and ankyrin repeat domains 4

affects expression

nickel chloride affects the expression of KANK4 mRNA

NCBI chr 5:113,401,491...113,465,526
Ensembl chr 5:113,402,468...113,465,555

G

lysine acetyltransferase 2B

affects expression

nickel chloride affects the expression of KAT2B mRNA

NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064

G

katanin catalytic subunit A1

affects expression

nickel chloride affects the expression of KATNA1 mRNA

NCBI chr 1:2,202,501...2,244,132
Ensembl chr 1:2,202,490...2,244,131

G

potassium channel tetramerization domain containing 15

affects expression

nickel chloride affects the expression of KCTD15 mRNA

NCBI chr 1:87,258,658...87,271,979
Ensembl chr 1:87,258,658...87,273,497

G

lysine demethylase 3A

affects expression
increases expression
multiple interactions

nickel chloride affects the expression of KDM3A mRNA
nickel chloride results in increased expression of KDM3A mRNA; nickel chloride results in increased expression of KDM3A protein
Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A mRNA]; Ascorbic Acid inhibits the reaction [nickel chloride results in increased expression of KDM3A protein]

PMID:17312168 PMID:21455298 PMID:22110744 PMID:22318714

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

lysine demethylase 4B

increases expression

nickel chloride results in increased expression of KDM4B mRNA

NCBI chr 9:1,158,737...1,237,233
Ensembl chr 9:1,158,752...1,236,543

G

lysine demethylase 6B

increases expression

nickel chloride results in increased expression of KDM6B mRNA; nickel chloride results in increased expression of KDM6B protein

NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794

G

lysine demethylase 7A

increases expression

nickel chloride results in increased expression of KDM7A mRNA

NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998

G

KH domain containing 4, pre-mRNA splicing factor

decreases expression

nickel chloride results in decreased expression of KHDC4 mRNA

NCBI chr 2:174,149,059...174,177,816
Ensembl chr 2:174,149,141...174,177,504

G

KIT proto-oncogene receptor tyrosine kinase

affects expression

nickel chloride affects the expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KIT ligand

decreases secretion
multiple interactions

nickel chloride results in decreased secretion of KITLG protein
[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of KITLG protein

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 10

increases expression
affects expression

nickel chloride results in increased expression of KLF10 mRNA
nickel chloride affects the expression of KLF10 mRNA

PMID:17547211 PMID:22546817

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

KLF transcription factor 4

increases expression

nickel chloride results in increased expression of KLF4 protein

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 5

affects expression

nickel chloride affects the expression of KLF5 mRNA

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

KLF transcription factor 6

increases expression
affects expression

nickel chloride results in increased expression of KLF6 mRNA
nickel chloride affects the expression of KLF6 mRNA

PMID:17547211 PMID:22110744

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

kelch-like family member 24

increases expression

nickel chloride results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

lysine methyltransferase 2A

affects expression
increases expression

nickel chloride affects the expression of KMT2A mRNA
nickel chloride results in increased expression of KMT2A mRNA

PMID:22110744 PMID:26378417

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

karyopherin subunit alpha 4

increases expression

nickel chloride results in increased expression of KPNA4 mRNA

NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081

G

kynureninase

increases expression

nickel chloride results in increased expression of KYNU mRNA

NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488

G

laminin subunit gamma 2

decreases expression

nickel chloride results in decreased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lipocalin 2

affects expression

nickel chloride affects the expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactate dehydrogenase A

increases expression
multiple interactions

nickel chloride results in increased expression of LDHA mRNA
2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [nickel chloride results in increased expression of LDHA mRNA]
Dinoprostone promotes the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]

PMID:12426141 PMID:12729255 PMID:12839937 PMID:22110744 PMID:27452194 More...

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

low density lipoprotein receptor

decreases expression

nickel chloride results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

lymphoid enhancer binding factor 1

affects expression

nickel chloride affects the expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

leptin

multiple interactions

[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein
nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]

PMID:10780946 PMID:18437699

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 2

affects expression

nickel chloride affects the expression of LGALS2 mRNA

NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802

G

galectin 7

affects expression

nickel chloride affects the expression of LGALS7 mRNA

NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015

G

DNA ligase 4

decreases expression

nickel chloride results in decreased expression of LIG4 mRNA

NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040

G

lin-7 homolog C, crumbs cell polarity complex component

decreases expression

nickel chloride results in decreased expression of LIN7C mRNA

NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728

G

lipase A, lysosomal acid type

decreases expression

nickel chloride results in decreased expression of LIPA mRNA

NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633

G

lipopolysaccharide-induced TNF factor

affects expression

nickel chloride affects the expression of LITAF mRNA

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

lysyl oxidase

increases expression

nickel chloride results in increased expression of LOX mRNA

PMID:17312168 PMID:21455298

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lysyl oxidase-like 2

affects expression

nickel chloride affects the expression of LOXL2 mRNA

NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067

G

lymphocyte-specific protein 1

affects expression

nickel chloride affects the expression of LSP1 mRNA

NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416

G

lanosterol synthase

decreases expression

nickel chloride results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

lymphotoxin beta

increases expression

nickel chloride results in increased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

LUC7-like 3 pre-mRNA splicing factor

decreases expression

nickel chloride results in decreased expression of CROP mRNA

NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538

G

lymphocyte antigen 96

multiple interactions

nickel chloride results in increased activity of [TLR4 protein binds to LY96 protein]

NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386

G

LYN proto-oncogene, Src family tyrosine kinase

affects expression

nickel chloride affects the expression of LYN mRNA

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

MAP-kinase activating death domain

affects expression

nickel chloride affects the expression of MADD mRNA

NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701

G

MAF bZIP transcription factor F

increases expression
affects expression

nickel chloride results in increased expression of MAFF mRNA
nickel chloride affects the expression of MAFF mRNA

PMID:17547211 PMID:22110744

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor K

affects expression

nickel chloride affects the expression of MAFK mRNA

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]; [nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

increases expression
multiple interactions

nickel chloride results in increased expression of MAP1LC3B mRNA
Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of MAP1LC3B mRNA]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

multiple interactions

nickel chloride promotes the reaction [Tretinoin results in increased expression of MAP2 mRNA]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

affects expression

nickel chloride affects the expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 3

multiple interactions

GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K3 protein]

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase 4

multiple interactions

GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K4 protein]

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen-activated protein kinase kinase 6

affects expression
increases response to substance
multiple interactions

nickel chloride affects the expression of MAP2K6 mRNA
MAP2K6 protein results in increased susceptibility to nickel chloride
[incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased expression of MAP2K6 mRNA; [incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased phosphorylation of MAP2K6 protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IFNG protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IL10 protein; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K6 protein]

PMID:21544193 PMID:22110744 PMID:23536762

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase 7

multiple interactions

GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K7 protein]

NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222

G

mitogen activated protein kinase kinase kinase 10

affects expression

nickel chloride affects the expression of MAP3K10 mRNA

NCBI chr 1:82,955,784...82,974,084
Ensembl chr 1:82,955,207...82,974,084

G

mitogen activated protein kinase kinase kinase 7

affects expression

nickel chloride affects the expression of MAP3K7 mRNA

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen-activated protein kinase kinase kinase 8

increases expression
affects expression

nickel chloride results in increased expression of MAP3K8 mRNA
nickel chloride affects the expression of MAP3K8 mRNA

PMID:17312168 PMID:22546817

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

nickel chloride results in increased phosphorylation of MAPK1 protein
[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of MAPK1 protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]; Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK1 protein]

PMID:25045119 PMID:30724446

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 12

affects expression

nickel chloride affects the expression of MAPK12 mRNA

NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664

G

mitogen activated protein kinase 13

affects expression

nickel chloride affects the expression of MAPK13 mRNA

NCBI chr20:6,835,277...6,845,500
Ensembl chr20:6,835,320...6,844,222

G

mitogen activated protein kinase 14

increases phosphorylation

nickel chloride results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

affects expression
increases phosphorylation
multiple interactions

nickel chloride affects the expression of MAPK3 mRNA
nickel chloride results in increased phosphorylation of MAPK3 protein
[nickel chloride results in increased abundance of Nickel] which results in increased phosphorylation of MAPK3 protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]; Nifedipine inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK3 protein]

PMID:22546817 PMID:25045119 PMID:30724446

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone promotes the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK8 protein]
MAPK8 affects the reaction [nickel chloride results in increased expression of PTGS2 mRNA]; MAPK8 affects the reaction [nickel chloride results in increased expression of PTGS2 protein]

PMID:17065197 PMID:21843586 PMID:38104653

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 8 interacting protein 1

affects expression

nickel chloride affects the expression of MAPK8IP1 mRNA

NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

pyrazolanthrone inhibits the reaction [nickel chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein, RP/EB family, member 1

affects expression

nickel chloride affects the expression of MAPRE1 mRNA

NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983

G

methionyl-tRNA synthetase 1

increases expression

nickel chloride results in increased expression of MARS1 mRNA

NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495

G

methionine adenosyltransferase 2A

decreases expression

nickel chloride results in decreased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

mannose binding lectin 2

affects expression

nickel chloride affects the expression of MBL2 mRNA

NCBI chr 1:228,016,439...228,024,736

G

muscleblind-like splicing regulator 2

increases expression

nickel chloride results in increased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

membrane bound O-acyltransferase domain containing 1

affects expression

nickel chloride affects the expression of MBOAT1 mRNA

NCBI chr17:34,331,413...34,445,088
Ensembl chr17:34,331,422...34,445,088

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression
affects expression
multiple interactions
increases expression

nickel chloride results in decreased expression of MCL1 mRNA
nickel chloride affects the expression of MCL1 mRNA
TP53 protein affects the reaction [nickel chloride results in increased expression of MCL1 mRNA]

PMID:17312168 PMID:22546817 PMID:23566959

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance complex component 2

decreases expression

nickel chloride results in decreased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 4

decreases expression

nickel chloride results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

affects expression

nickel chloride affects the expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

affects expression

nickel chloride affects the expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

mediator of DNA damage checkpoint 1

affects expression

nickel chloride affects the expression of MDC1 mRNA

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

malate dehydrogenase 2

increases activity

nickel chloride results in increased activity of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

midkine

affects expression

nickel chloride affects the expression of MDK mRNA

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

MDM2 proto-oncogene

multiple interactions
affects expression
increases expression

TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA]
nickel chloride affects the expression of MDM2 mRNA

PMID:22546817 PMID:23566959 PMID:28552779

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

MDM4 regulator of p53

decreases expression
affects expression

nickel chloride results in decreased expression of MDM4 protein
nickel chloride affects the expression of MDM4 mRNA

PMID:22546817 PMID:23566959

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

G

mediator complex subunit 13

decreases expression

nickel chloride results in decreased expression of MED13 mRNA

NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242

G

menin 1

affects expression

nickel chloride affects the expression of MEN1 mRNA

NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871

G

MER proto-oncogene, tyrosine kinase

decreases expression

nickel chloride results in decreased expression of MERTK mRNA

NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554

G

mex-3 RNA binding family member B

affects expression

nickel chloride affects the expression of MEX3B mRNA

NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354

G

mitofusin 1

multiple interactions
decreases expression

[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MFN1 mRNA
nickel chloride results in decreased expression of MFN1 mRNA; nickel chloride results in decreased expression of MFN1 protein

PMID:36794572 PMID:38552765

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

multiple interactions
decreases expression

[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MFN2 mRNA; [nickel chloride results in increased abundance of Nickel] which results in decreased expression of MFN2 protein
nickel chloride results in decreased expression of MFN2 mRNA; nickel chloride results in decreased expression of MFN2 protein

PMID:36794572 PMID:38552765

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

mitochondria-localized glutamic acid-rich protein

affects expression

nickel chloride affects the expression of MGARP mRNA

NCBI chr 2:135,431,283...135,439,425
Ensembl chr 2:135,431,283...135,439,612

G

monoglyceride lipase

affects expression

nickel chloride affects the expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

microRNA 21

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in increased expression of MIR21 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in increased expression of MIR21 mRNA]; [nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of RECK protein; [nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of SPRY2 protein

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 210

increases expression

nickel chloride results in increased expression of MIR210 mRNA

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

mitochondrial matrix import factor 23

affects expression

nickel chloride affects the expression of MIX23 mRNA

NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000

G

MAPK interacting serine/threonine kinase 1

multiple interactions

HIF1A affects the reaction [nickel chloride results in increased expression of MKNK1 mRNA]

NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639

G

mutL homolog 1

affects expression
decreases expression

nickel chloride affects the expression of MLH1 mRNA
nickel chloride results in decreased expression of MLH1 mRNA; nickel chloride results in decreased expression of MLH1 protein

PMID:22546817 PMID:28472268

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 2

increases expression

nickel chloride results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

increases expression
multiple interactions
increases activity

nickel chloride results in increased expression of MMP9 protein
chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; nickel chloride results in increased expression of and results in increased activity of MMP9 protein; Quercetin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; SC 514 inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]
nickel chloride results in increased activity of MMP9 protein

PMID:21473897 PMID:26962057 PMID:30016632

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

modulator of apoptosis 1

decreases expression

nickel chloride results in decreased expression of MOAP1 mRNA

NCBI chr 6:121,882,565...121,884,500
Ensembl chr 6:121,882,366...121,898,643
Ensembl chr17:121,882,366...121,898,643

G

myeloperoxidase

multiple interactions

[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of MPO protein; [nickel chloride results in increased abundance of Nickel] which results in increased activity of MPO protein; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein S6

decreases expression

nickel chloride results in decreased expression of MRPS6 mRNA

NCBI chr11:31,295,358...31,348,483
Ensembl chr11:31,295,614...31,348,484

G

magnesium transporter MRS2

decreases expression

nickel chloride results in decreased expression of MRS2 mRNA

NCBI chr17:40,063,924...40,087,073
Ensembl chr17:40,063,962...40,081,887

G

methylsterol monooxygenase 1

decreases expression

nickel chloride results in decreased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA]

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

multiple interactions
decreases expression

Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA]

NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061

G

metallothionein 1

affects expression
increases expression

nickel chloride affects the expression of MT1A mRNA
nickel chloride results in increased expression of MT1 mRNA

PMID:12729255 PMID:22110744

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

affects expression
increases expression

nickel chloride affects the expression of MT2A mRNA
nickel chloride results in increased expression of MT2A mRNA

PMID:22110744 PMID:26378417 PMID:28472268

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mitochondrial carrier 1

affects expression

nickel chloride affects the expression of MTCH1 mRNA

NCBI chr20:7,389,942...7,413,426
Ensembl chr20:7,389,949...7,413,426

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

increases expression

nickel chloride results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

myotubularin related protein 7

affects expression

nickel chloride affects the expression of MTMR7 mRNA

NCBI chr16:51,641,267...51,732,212
Ensembl chr16:51,641,190...51,732,182

G

mechanistic target of rapamycin kinase

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; [nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA; [nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in decreased expression of MTOR mRNA]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in decreased expression of MTOR mRNA]

PMID:35568058 PMID:36421005

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

microsomal triglyceride transfer protein

affects expression

nickel chloride affects the expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

MX dynamin like GTPase 1

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MAX interactor 1, dimerization protein

increases expression

nickel chloride results in increased expression of MXI1 mRNA

PMID:17312168 PMID:21455298

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYB proto-oncogene like 2

affects expression

nickel chloride affects the expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

affects expression
increases expression

nickel chloride affects the expression of MYC mRNA
nickel chloride results in increased expression of MYC protein

PMID:22110744 PMID:22546817 PMID:28552779

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYC binding protein 2

affects expression

nickel chloride affects the expression of MYCBP2 mRNA

NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498

G

MYCL proto-oncogene, bHLH transcription factor

affects expression

nickel chloride affects the expression of MYCL mRNA

NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582

G

MYCN proto-oncogene, bHLH transcription factor

affects expression

nickel chloride affects the expression of MYCN mRNA

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

MYD88, innate immune signal transduction adaptor

increases expression
multiple interactions

nickel chloride results in increased expression of MYD88 mRNA; nickel chloride results in increased expression of MYD88 protein
chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of CXCL8 protein]; MYD88 mutant form inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; Quercetin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; Quercetin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein]

PMID:21473897 PMID:24080332 PMID:30016632

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

N(alpha)-acetyltransferase 10, NatA catalytic subunit

decreases expression

nickel chloride results in decreased expression of NAA10 mRNA

NCBI chr X:151,656,056...151,661,304
Ensembl chr X:151,656,056...151,661,252

G

nucleic acid binding protein 1

affects expression

nickel chloride affects the expression of NABP1 mRNA

NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107

G

nicotinamide phosphoribosyltransferase

affects expression

nickel chloride affects the expression of NAMPT mRNA

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

neuron navigator 2

increases expression

nickel chloride results in increased expression of NAV2 mRNA

NCBI chr 1:98,957,629...99,322,339
Ensembl chr 1:98,663,759...99,322,337

G

neural cell adhesion molecule 1

multiple interactions

[nickel chloride co-treated with Nicotine] results in increased expression of NCAM1 mRNA; nickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 mRNA]; nickel chloride promotes the reaction [Tretinoin results in increased expression of NCAM1 protein]

PMID:25614230 PMID:37951547

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

nuclear receptor coactivator 4

decreases expression

nickel chloride results in decreased expression of NCOA4 mRNA; nickel chloride results in decreased expression of NCOA4 protein

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

N-myc downstream regulated 1

multiple interactions
increases expression
affects expression

[nickel chloride co-treated with VHL protein] results in increased expression of NDRG1 mRNA
nickel chloride results in increased expression of NDRG1 mRNA; nickel chloride results in increased expression of NDRG1 protein
[nickel chloride co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA; AKT1 protein affects the reaction [nickel chloride results in increased expression of NDRG1 protein]; HIF1A affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]; HIF1A protein affects the reaction [nickel chloride results in increased expression of NDRG1 mRNA]
nickel chloride affects the expression of NDRG1 mRNA

PMID:10646848 PMID:10910041 PMID:12729255 PMID:12767066 PMID:14729612 More...

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NDRG family member 2

affects expression

nickel chloride affects the expression of NDRG2 mRNA

NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626

G

NIMA-related kinase 2

affects expression

nickel chloride affects the expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

NIMA-related kinase 3

affects expression

nickel chloride affects the expression of NEK3 mRNA

NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

affects expression

nickel chloride affects the expression of NF2 mRNA

NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
affects localization

Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of NFE2L2 protein]; lipopolysaccharide A promotes the reaction [nickel chloride affects the localization of NFE2L2 protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of NFE2L2 protein]; nickel chloride promotes the reaction [lipopolysaccharide A results in increased expression of NFE2L2 protein]

PMID:16806455 PMID:18437699

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor, interleukin 3 regulated

affects expression
increases expression

nickel chloride affects the expression of NFIL3 mRNA
nickel chloride results in increased expression of NFIL3 mRNA

PMID:17312168 PMID:22110744

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions
affects expression

nickel chloride results in increased expression of NFKB1 mRNA
[nickel chloride results in increased abundance of Nickel] which results in increased expression of NFKB1 protein; nickel chloride binds to and affects the localization of NFKB1 protein
nickel chloride affects the expression of NFKB1 mRNA

PMID:17312168 PMID:22546817 PMID:23844176 PMID:30724446

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

increases expression

nickel chloride results in increased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

decreases expression
increases phosphorylation
multiple interactions
increases expression

nickel chloride results in decreased expression of NFKBIA mRNA
nickel chloride results in increased phosphorylation of NFKBIA protein
[nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of CXCL8 protein]; [nickel chloride results in increased phosphorylation of NFKBIA protein] inhibits the reaction [nickel chloride results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; Quercetin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]; SC 514 inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
nickel chloride results in increased expression of NFKBIA mRNA

PMID:16982623 PMID:17312168 PMID:17547211 PMID:24080332 PMID:25803856 More...

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nuclear transcription factor Y subunit alpha

increases expression

nickel chloride results in increased expression of NFYA mRNA

NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898

G

nuclear transcription factor Y subunit gamma

affects expression

nickel chloride affects the expression of NFYC mRNA

NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377

G

nonhomologous end-joining factor 1

affects expression

nickel chloride affects the expression of NHEJ1 mRNA

NCBI chr 9:76,526,322...76,622,488
Ensembl chr 9:76,526,324...76,622,444

G

NLR family, CARD domain containing 4

affects expression

nickel chloride affects the expression of NLRC4 mRNA

NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248

G

NLR family, pyrin domain containing 12

multiple interactions

nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NLRP12 mRNA]

NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934

G

NLR family, pyrin domain containing 3

multiple interactions

NLRP3 protein promotes the reaction [[Lipopolysaccharides co-treated with nickel chloride] results in increased secretion of IL1B protein]
[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein; Resveratrol inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of NLRP3 protein]

PMID:24158569 PMID:31943712

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 3

affects expression

nickel chloride affects the expression of NME3 mRNA

PMID:22110744 PMID:22546817

NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359

G

N-myristoyltransferase 2

increases expression

nickel chloride results in increased expression of NMT2 mRNA

NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080

G

nucleotide-binding oligomerization domain containing 1

multiple interactions

nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA]

NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404

G

nucleolar protein 3

affects expression

nickel chloride affects the expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

nitric oxide synthase 2

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [nickel chloride results in decreased expression of NOS2 mRNA]
nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]

PMID:8975779 PMID:18830972

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

nickel chloride inhibits the reaction [fluoranthene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [fluorene results in increased expression of NOS3 protein]; nickel chloride inhibits the reaction [naphthalene results in increased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

affects expression
increases expression

nickel chloride affects the expression of NOTCH1 mRNA
nickel chloride results in increased expression of NOTCH1 protein

PMID:22546817 PMID:26962057

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

increases expression

nickel chloride results in increased expression of NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
decreases expression

nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]
nickel chloride results in decreased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

nickel chloride results in decreased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 2, group F, member 6

affects expression

nickel chloride affects the expression of NR2F6 mRNA

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

increases expression

nickel chloride results in increased expression of NR3C1 mRNA