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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mevastatin
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Accession:CHEBI:34848 term browser browse the term
Definition:A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.
Synonyms:exact_synonym: (1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
 related_synonym: CS 500;   Compactin;   Formula=C23H34O5;   InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1;   InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N;   ML 236 B;   ML-236B;   SMILES=CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12;   antibiotic ML 236B;   mevastatina;   mevastatine;   mevastatinum
 alt_id: MESH:C012258
 xref: CAS:73573-88-3;   DrugBank:DB06693;   KEGG:C13963;   KNApSAcK:C00000564;   LINCS:LSM-4123
 xref_mesh: MESH:C012258
 xref: PMID:11283400;   PMID:12403272;   PMID:15274361;   PMID:15531285;   PMID:15786722;   PMID:18672387;   PMID:18936176;   PMID:20629200;   PMID:23918904;   PMID:24462564;   PMID:3170348;   PMID:3719857;   Patent:DE2524355;   Patent:US3983140;   Reaxys:3630717;   Wikipedia:Mevastatin


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mevastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects expression
decreases expression
multiple interactions		 EXP
ISO		 mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]]		 CTD
RGD		 PMID:16415093 PMID:17526932 PMID:17526932 RGD:2308820 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein CTD PMID:10814523 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:15466163 PMID:17041008 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression		 ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA] CTD PMID:16330322 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO mevastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 multiple interactions
increases expression		 ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA] CTD PMID:16330322 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifng interferon gamma multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO mevastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression
multiple interactions		 ISO mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]		 CTD PMID:16330322 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Mstn myostatin increases expression ISO mevastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Mevastatin increases expression of NR1H3 mRNA in mononuclear cells RGD PMID:16252156 RGD:401827902 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] CTD PMID:16734383 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A decreases lipidation
multiple interactions		 ISO mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]		 CTD PMID:17322126 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Sele selectin E multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases cleavage
multiple interactions		 EXP
ISO		 mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]		 CTD PMID:16330322 PMID:17526932 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
increases cleavage		 EXP
ISO		 mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein		 CTD PMID:16330322 PMID:17526932 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein] CTD PMID:16330322 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
lovastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
decreases expression
multiple interactions		 ISO Lovastatin results in increased expression of ABCA1 mRNA
lovastatin decreases expression of ABCA1 mRNA in HepG2 cells
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCA1 mRNA
Lovastatin results in decreased expression of ABCA1 mRNA		 CTD
RGD		 PMID:19260826 PMID:29852127 PMID:27765770 RGD:18936994 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Lovastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lovastatin results in decreased activity of ABCB11 protein		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
increases transport		 ISO Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Lovastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Lovastatin; ABCB1 protein results in increased transport of Lovastatin analog		 CTD PMID:15616150 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions		 ISO Lovastatin results in decreased activity of ABCC1 protein
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate; Doxorubicin inhibits the reaction [Lovastatin results in increased expression of ABCC1 mRNA]		 CTD PMID:18056276 PMID:22712078 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity		 ISO
EXP		 ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Lovastatin results in increased expression of ABCC2 mRNA
Lovastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]		 CTD PMID:15616150 PMID:23562342 PMID:26739623 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression
multiple interactions		 ISO Lovastatin affects the expression of ABCG5 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCG5 mRNA		 CTD PMID:27208389 PMID:29852127 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 affects expression ISO Lovastatin affects the expression of ABCG8 mRNA CTD PMID:27208389 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACACA mRNA CTD PMID:29852127 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACOX1 mRNA CTD PMID:29852127 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACSS2 mRNA CTD PMID:29852127 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Lovastatin results in decreased expression of ACTA2 protein		 CTD PMID:22129737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta decreases expression
increases expression		 ISO Lovastatin results in decreased expression of ACTB mRNA
Lovastatin results in increased expression of ACTB mRNA		 CTD PMID:20493250 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actr3 actin related protein 3 increases expression ISO Lovastatin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression
multiple interactions		 EXP
ISO		 Lovastatin results in increased expression of ADAM10 protein
[Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein		 CTD PMID:29341888 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects expression
multiple interactions		 ISO Lovastatin affects the expression of ADIPOQ mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ADIPOQ mRNA		 CTD PMID:27208389 PMID:29852127 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Lovastatin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393 		JBrowse link
G Akap7 A-kinase anchoring protein 7 decreases response to substance ISO AKAP7 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]
Lovastatin results in decreased phosphorylation of AKT1 protein		 CTD PMID:16425225 PMID:17472962 PMID:19760159 PMID:20578043 PMID:35734936 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions EXP Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein] CTD PMID:35734936 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Ank2 ankyrin 2 decreases response to substance ISO ANK2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Anxa4 annexin A4 decreases expression ISO Lovastatin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa5 annexin A5 decreases expression ISO Lovastatin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Lovastatin co-treated with Niacin] results in increased expression of APOA1 protein; [Niacin co-treated with Lovastatin] results in increased expression of APOA1 protein CTD PMID:12633795 PMID:17319473 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B multiple interactions
decreases secretion		 ISO [Niacin co-treated with Lovastatin] results in decreased expression of APOB protein
Lovastatin results in decreased secretion of APOB protein		 CTD PMID:11728391 PMID:12633795 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E affects expression
multiple interactions		 ISO Lovastatin affects the expression of APOE mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA		 CTD PMID:27208389 PMID:29852127 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases cleavage
increases secretion		 EXP
ISO		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; U 0126 inhibits the reaction [Lovastatin results in increased secretion of APP protein]
[APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein; [Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein; [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein; [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[APP protein co-treated with Lovastatin] results in increased secretion of APP protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased cleavage of APP protein
Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP protein modified form		 CTD PMID:19741129 PMID:29341888 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Lovastatin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 increases expression ISO Lovastatin results in increased expression of ASIC3 mRNA CTD PMID:38432573 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form] CTD PMID:26739623 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form] CTD PMID:26739623 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bace1 beta-secretase 1 decreases expression
multiple interactions		 EXP
ISO		 Lovastatin results in decreased expression of BACE1 protein
[Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein		 CTD PMID:29341888 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bace2 beta-secretase 2 multiple interactions
increases expression		 ISO
EXP		 [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein
Lovastatin results in increased expression of BACE2 protein		 CTD PMID:29341888 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects localization		 ISO
EXP		 Lovastatin results in increased expression of BAX protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]; Lovastatin promotes the reaction [Cisplatin results in increased expression of BAX mRNA]
Lovastatin affects the localization of BAX protein		 CTD PMID:10473109 PMID:15180944 PMID:26739623 PMID:35734936 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases cleavage
multiple interactions		 EXP Lovastatin results in increased cleavage of BCAR1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]		 CTD PMID:16367743 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Lovastatin results in decreased expression of BCL2 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein]		 CTD PMID:10473109 PMID:11178870 PMID:12094262 PMID:35734936 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 EXP Lovastatin results in decreased expression of BCL2L1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein]		 CTD PMID:11178870 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression		 ISO
EXP		 pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]		 CTD PMID:18766339 PMID:35734936 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 PMID:18815881 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of BRCA2 mRNA] CTD PMID:22712078 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Lovastatin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Calr calreticulin increases expression ISO Lovastatin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Casp2 caspase 2 increases activity
multiple interactions		 ISO Lovastatin results in increased activity of CASP2 protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]		 CTD PMID:12933658 PMID:16234849 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression		 ISO
EXP		 farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
Lovastatin analog results in increased cleavage of CASP3 protein
Lovastatin results in increased activity of CASP3 protein
Lovastatin results in decreased expression of CASP3 mRNA
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]; Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]		 CTD PMID:11720884 PMID:12933658 PMID:15180944 PMID:16367743 PMID:18034278 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases activity ISO Lovastatin results in increased activity of CASP6 protein CTD PMID:11720884 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp8 caspase 8 increases activity ISO Lovastatin results in increased activity of CASP8 protein CTD PMID:15180944 PMID:15705602 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO
EXP		 Lovastatin results in increased activity of CASP9 protein
Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]		 CTD PMID:12933658 PMID:15180944 PMID:15705602 PMID:35734936 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP Lovastatin inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein] CTD PMID:35734936 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression		 ISO
EXP		 Lovastatin results in decreased expression of CCND1 protein
Lovastatin results in increased expression of CCND1 mRNA; Lovastatin results in increased expression of CCND1 protein		 CTD PMID:18034278 PMID:20578043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Lovastatin results in decreased expression of CCND3 protein CTD PMID:10502407 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Lovastatin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Lovastatin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Lovastatin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO Lovastatin results in decreased expression of CD44 mRNA; Lovastatin results in decreased expression of CD44 protein CTD PMID:21199873 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdc42 cell division cycle 42 increases expression
decreases expression		 ISO Lovastatin results in increased expression of CDC42 protein
Lovastatin results in decreased expression of CDC42 mRNA		 CTD PMID:18766339 PMID:20493250 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Lovastatin results in decreased activity of CDK2 protein CTD PMID:10502407 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Lovastatin results in decreased expression of CDK4 mRNA; Lovastatin results in decreased expression of CDK4 protein CTD PMID:20578043 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases cleavage EXP Lovastatin results in decreased cleavage of CDK5 protein CTD PMID:19741129 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Lovastatin results in increased expression of CDKN1A protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]		 CTD PMID:18034278 PMID:22712078 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP
ISO		 Lovastatin results in increased expression of CDKN1B mRNA; Lovastatin results in increased expression of CDKN1B protein CTD PMID:9848777 PMID:10502407 PMID:15118409 PMID:18034278 PMID:20578043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form] CTD PMID:26739623 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Cenpf centromere protein F increases expression
multiple interactions		 ISO Lovastatin results in increased expression of CENPF protein
Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]		 CTD PMID:12467231 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669 		JBrowse link
G Cfl1 cofilin 1 decreases phosphorylation EXP Lovastatin results in decreased phosphorylation of CFL1 protein CTD PMID:20578043 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO
EXP		 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form]		 CTD PMID:17088865 PMID:21356574 PMID:26739623 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases expression		 ISO
EXP		 [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]
Lovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 protein
U 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]		 CTD PMID:29341888 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Lovastatin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Lovastatin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein] CTD PMID:35734936 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Lovastatin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crp C-reactive protein multiple interactions EXP Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein] CTD PMID:35734936 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Ctnnb1 catenin beta 1 decreases degradation
increases expression
multiple interactions		 EXP
ISO		 Lovastatin results in decreased degradation of CTNNB1 protein
Lovastatin results in increased expression of CTNNB1 mRNA
Lovastatin affects the localization of and results in increased expression of CTNNB1 protein		 CTD PMID:17234346 PMID:19741129 PMID:24742230 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]; Lovastatin results in increased expression of and results in increased activity of CYP1A1 protein
Lovastatin results in increased expression of CYP1A1 mRNA		 CTD PMID:1311272 PMID:22712078 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Lovastatin results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Lovastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Lovastatin results in increased expression of CYP3A4 mRNA		 CTD PMID:12505310 PMID:17041008 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Lovastatin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Lovastatin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482 		JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:65,859,653...65,911,887
Ensembl chr  X:65,860,172...65,910,322 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Lovastatin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Lovastatin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Lovastatin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Lovastatin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Lovastatin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein] CTD PMID:12942316 PMID:19760159 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:12942316 PMID:19760159 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Lovastatin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression
multiple interactions		 EXP Lovastatin results in increased expression of ERCC1 mRNA
Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA]		 CTD PMID:26739623 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease multiple interactions
increases expression		 EXP Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]
Lovastatin results in increased expression of ERCC5 mRNA		 CTD PMID:26739623 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases expression EXP Lovastatin results in increased expression of ERCC6 mRNA CTD PMID:26739623 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Lovastatin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FADS2 mRNA CTD PMID:29852127 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO
EXP		 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]		 CTD PMID:17088865 PMID:35734936 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA] CTD PMID:17088865 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Lovastatin results in increased expression of FASN mRNA CTD PMID:11728391 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression		 ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]; Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]
Lovastatin results in increased expression of FBXO32 mRNA; Lovastatin results in increased expression of FBXO32 protein		 CTD PMID:19406843 PMID:33408297 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases activity ISO Lovastatin results in increased activity of FDFT1 protein CTD PMID:8517861 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO
EXP		 [Dietary Fats co-treated with Lovastatin] affects the expression of FDPS mRNA
[Cholestyramine Resin co-treated with Lovastatin] results in increased expression of FDPS mRNA; Mevalonic Acid inhibits the reaction [[Cholestyramine Resin co-treated with Lovastatin] results in increased expression of FDPS mRNA]		 CTD PMID:3670308 PMID:29852127 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Flot1 flotillin 1 decreases expression ISO Lovastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression		 EXP
ISO		 Lovastatin affects the expression of FOS protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]
Lovastatin results in decreased expression of FOS		 CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein] CTD PMID:18434508 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases phosphorylation		 ISO Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]
Lovastatin results in decreased phosphorylation of FOXO1 protein		 CTD PMID:33034787 PMID:33408297 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Lovastatin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Lovastatin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of G6PD mRNA CTD PMID:29852127 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Lovastatin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388 		JBrowse link
G Gap43 growth associated protein 43 increases expression ISO Lovastatin results in increased expression of GAP43 protein CTD PMID:20694854 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Lovastatin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Gk glycerol kinase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of GK mRNA CTD PMID:29852127 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Lovastatin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; Lovastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:29852127 PMID:30853469 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] CTD PMID:24718106 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases phosphorylation		 ISO
EXP		 Lovastatin results in decreased phosphorylation of GSK3B protein
Lovastatin results in increased phosphorylation of GSK3B protein		 CTD PMID:17234346 PMID:19741129 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP		 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]		 CTD PMID:21356574 PMID:22712078 PMID:26739623 PMID:28710503 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Lovastatin results in increased expression of HAS1 mRNA; Lovastatin results in increased expression of HAS1 protein CTD PMID:38432573 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397 		JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO Lovastatin results in increased expression of HAS2 mRNA CTD PMID:38432573 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Lovastatin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Lovastatin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
affects expression
decreases activity
increases expression		 ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]
[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA
Lovastatin affects the expression of HMGCR mRNA
Lovastatin results in increased expression of HMGCR mRNA		 CTD PMID:8517861 PMID:8593127 PMID:17208200 PMID:19260826 PMID:19699819 More... NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNA CTD PMID:29852127 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Lovastatin results in increased expression of HMOX1 protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]		 CTD PMID:20594940 PMID:21910007 PMID:28710503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Lovastatin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Lovastatin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Lovastatin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression		 ISO Lovastatin results in decreased expression of HNRNPK mRNA
Lovastatin results in increased expression of HNRNPK mRNA		 CTD PMID:20493250 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases prenylation
multiple interactions		 ISO Lovastatin results in decreased prenylation of HRAS protein
Lovastatin results in decreased prenylation of and results in decreased localization of HRAS protein		 CTD PMID:16156861 PMID:19360310 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Lovastatin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Lovastatin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Lovastatin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Lovastatin CTD PMID:9525472 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein] CTD PMID:19741129 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:18809656 PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]		 CTD PMID:28710503 PMID:35734936 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insig1 insulin induced gene 1 increases expression
multiple interactions		 ISO Lovastatin results in increased expression of INSIG1 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA		 CTD PMID:19260826 PMID:29852127 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of INSIG2 mRNA CTD PMID:29852127 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Insr insulin receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Ipo5 importin 5 decreases expression ISO Lovastatin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO Lovastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA CTD PMID:29852127 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Lovastatin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Lovastatin results in decreased expression of ITGB1 protein CTD PMID:12405293 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression		 EXP
ISO		 Lovastatin affects the expression of JUN protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA]
Lovastatin results in decreased expression of JUN		 CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO Lovastatin affects the activity of KCNH2 protein CTD PMID:16278312 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 increases expression ISO Lovastatin results in increased expression of KCNJ11 mRNA CTD PMID:38432573 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases prenylation
increases expression
affects localization
increases activity		 ISO Lovastatin results in decreased prenylation of KRAS protein
Lovastatin results in increased expression of KRAS protein
Lovastatin affects the localization of KRAS protein
Lovastatin results in increased activity of KRAS protein		 CTD PMID:12106604 PMID:12907238 PMID:16156861 PMID:17005160 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt18 keratin 18 decreases expression ISO Lovastatin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166 		JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Lovastatin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO Lovastatin results in increased expression of LDHA protein CTD PMID:38432573 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
increases expression		 ISO
EXP		 OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of LDLR mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]
Lovastatin results in increased activity of LDLR protein		 CTD PMID:8593127 PMID:11728391 PMID:12524230 PMID:20578043 PMID:29852127 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects localization ISO Lovastatin affects the localization of LEF1 protein CTD PMID:17234346 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lipc lipase C, hepatic type affects expression ISO Lovastatin affects the expression of LIPC mRNA CTD PMID:27208389 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lmnb1 lamin B1 decreases farnesylation
increases degradation
affects localization		 ISO Lovastatin results in decreased farnesylation of LMNB1 protein
Lovastatin results in increased degradation of LMNB1 protein
Lovastatin affects the localization of LMNB1 protein		 CTD PMID:10203554 PMID:11720884 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Lpin2 lipin 2 decreases response to substance ISO LPIN2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193 		JBrowse link
G Lpl lipoprotein lipase affects expression
multiple interactions		 ISO Lovastatin affects the expression of LPL mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of LPL mRNA		 CTD PMID:27208389 PMID:29852127 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrp5 LDL receptor related protein 5 increases expression ISO Lovastatin results in increased expression of LRP5 mRNA CTD PMID:24742230 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
increases phosphorylation
decreases activity
decreases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK1 protein]
Lovastatin results in increased expression of MAPK1 protein
Lovastatin results in decreased activity of MAPK1 protein
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]		 CTD PMID:12213976 PMID:16952276 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Lovastatin results in increased expression of MAPK14 protein CTD PMID:38432573 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
increases phosphorylation
decreases activity
decreases phosphorylation		 ISO
EXP		 [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased expression of MAPK3 protein
Lovastatin results in increased phosphorylation of MAPK3 protein
Lovastatin results in decreased activity of MAPK3 protein
Lovastatin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16952276 PMID:18434508 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form] CTD PMID:26739623 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK9 protein modified form] CTD PMID:26739623 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mbp myelin basic protein multiple interactions
increases expression		 EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA] CTD PMID:20578043 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217 		JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Lovastatin results in decreased expression of MMP2 protein CTD PMID:19360310 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lovastatin results in decreased expression of MMP9 protein CTD PMID:19360310 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein] CTD PMID:35734936 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mstn myostatin increases expression ISO Lovastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Doxorubicin inhibits the reaction [Lovastatin results in increased expression of NFE2L2 mRNA]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Lovastatin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]		 CTD PMID:18809656 PMID:35734936 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Lovastatin results in increased expression of NQO1 mRNA CTD PMID:1311272 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases prenylation ISO Lovastatin results in decreased prenylation of NRAS protein CTD PMID:16156861 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Lovastatin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220 		JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Lovastatin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Osm oncostatin M multiple interactions ISO OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA] CTD PMID:12524230 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Lovastatin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Lovastatin analog results in increased cleavage of PARP1 protein CTD PMID:26863638 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parvb parvin, beta decreases response to substance ISO PARVB SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 7:115,360,254...115,445,767
Ensembl chr 7:115,360,261...115,445,766 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of PCK1 mRNA CTD PMID:29852127 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression EXP Lovastatin results in decreased expression of PDGFRA mRNA CTD PMID:20578043 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression
increases expression		 ISO Lovastatin results in decreased expression of PDIA3 mRNA
Lovastatin results in increased expression of PDIA3 mRNA		 CTD PMID:20493250 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Lovastatin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression		 ISO Lovastatin results in decreased expression of PGAM1 mRNA
Lovastatin results in increased expression of PGAM1 mRNA		 CTD PMID:20493250 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Lovastatin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pla2g4a phospholipase A2 group 4A increases expression EXP Lovastatin results in increased expression of PLA2G4A mRNA CTD PMID:20578043 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions
increases secretion
increases expression		 EXP
ISO		 geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Lovastatin results in increased secretion of PLAT protein		 CTD PMID:10412747 PMID:12405293 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO Lovastatin results in decreased secretion of PLAU protein CTD PMID:12405293 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis
increases metabolic processing
multiple interactions		 ISO PON3 protein results in increased hydrolysis of Lovastatin
PON3 protein results in increased metabolism of Lovastatin
7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]		 CTD PMID:12615656 PMID:15772423 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects localization
increases expression		 ISO
EXP		 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; Lovastatin results in increased expression of and affects the localization of PPARG protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of PPARG mRNA; PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]		 CTD PMID:16425225 PMID:20578043 PMID:26863638 PMID:29852127 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Lovastatin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Lovastatin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Prg4 proteoglycan 4 increases expression ISO Lovastatin results in increased expression of PRG4 mRNA; Lovastatin results in increased expression of PRG4 protein CTD PMID:38432573 NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119 		JBrowse link
G Prkca protein kinase C, alpha increases expression ISO Lovastatin results in increased expression of PRKCA protein CTD PMID:38432573 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases cleavage		 EXP benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Lovastatin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965 		JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Lovastatin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Lovastatin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression		 ISO
EXP		 Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]		 CTD PMID:16425225 PMID:20578043 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions		 ISO
EXP		 Lovastatin results in decreased expression of PTGS2 protein
Lovastatin analog results in increased expression of PTGS2 mRNA; Lovastatin analog results in increased expression of PTGS2 protein
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]
Lovastatin results in increased expression of PTGS2 mRNA; Lovastatin results in increased expression of PTGS2 protein		 CTD PMID:20578043 PMID:21910007 PMID:26863638 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Lovastatin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects localization
decreases activity
increases expression		 ISO geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Lovastatin results in decreased activity of RAC1 protein
Lovastatin results in increased expression of RAC1 protein		 CTD PMID:12933658 PMID:18766339 PMID:19360310 PMID:21356574 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
decreases activity		 ISO Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]
Lovastatin results in decreased activity of RAF1 protein		 CTD PMID:19360310 PMID:19760159 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family increases expression ISO Lovastatin results in increased expression of RAP1A protein CTD PMID:12467231 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP
ISO		 Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:9848777 PMID:10502407 PMID:15118409 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases expression
decreases prenylation
affects localization		 ISO
EXP		 geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Lovastatin results in decreased geranoylation of and affects the localization of RHOA protein
Lovastatin results in decreased expression of RHOA mRNA
Lovastatin results in decreased prenylation of RHOA protein
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]		 CTD PMID:9398081 PMID:11178870 PMID:12405293 PMID:12933658 PMID:16156861 More... NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhob ras homolog family member B decreases prenylation
multiple interactions
increases expression		 ISO Lovastatin results in decreased prenylation of RHOB protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
Lovastatin results in increased expression of RHOB protein		 CTD PMID:12467231 PMID:16156861 PMID:16234849 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Lovastatin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193 		JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Lovastatin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
Ensembl chr 3:42,893,942...42,897,136
Ensembl chr 1:42,893,942...42,897,136 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Lovastatin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Lovastatin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Lovastatin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Lovastatin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986 		JBrowse link
G Scap SREBF chaperone multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA CTD PMID:29852127 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects expression		 ISO [Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
Lovastatin affects the expression of SCARB1 mRNA		 CTD PMID:20404351 PMID:27208389 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCD1 mRNA CTD PMID:29852127 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Lovastatin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:73,354,435...73,382,803
Ensembl chr17:73,356,530...73,382,593 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression EXP Lovastatin results in increased expression of SLC31A1 mRNA CTD PMID:26739623 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Sox10 SRY-box transcription factor 10 multiple interactions
increases expression		 EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA] CTD PMID:20578043 NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNA
Lovastatin results in increased expression of SREBF1 mRNA		 CTD PMID:29852127 PMID:32739440 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases localization
multiple interactions		 ISO
EXP		 Lovastatin results in increased localization of SREBF2 protein
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]		 CTD PMID:11728391 PMID:20578043 PMID:29852127 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Steap2 STEAP2 metalloreductase decreases response to substance ISO STEAP2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Lovastatin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672 		JBrowse link
G Tcp1 t-complex 1 increases expression ISO Lovastatin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839 		JBrowse link
G Tg thyroglobulin increases secretion ISO Lovastatin results in increased secretion of TG protein CTD PMID:12843138 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions		 ISO Lovastatin results in increased expression of TH protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]		 CTD PMID:20694854 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Lovastatin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]
Lovastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]		 CTD PMID:18809656 PMID:21430599 PMID:22712078 PMID:35734936 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Lovastatin results in increased expression of TNFRSF11B mRNA CTD PMID:24742230 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Lovastatin results in increased susceptibility to TNFSF10 protein CTD PMID:17928957 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Lovastatin results in decreased expression of TNFSF11 mRNA CTD PMID:24742230 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO
EXP		 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Lovastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein modified form]
Lovastatin results in increased expression of TP53 mRNA		 CTD PMID:17088865 PMID:21199873 PMID:26739623 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein] CTD PMID:33408297 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FSN mRNA CTD PMID:29852127 NCBI chr 6:7,159,285...7,261,826
Ensembl chr 6:7,159,061...7,261,892 		JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Lovastatin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba1b tubulin, alpha 1B increases expression
decreases expression		 ISO Lovastatin results in increased expression of TUBA1B mRNA
Lovastatin results in decreased expression of TUBA1B mRNA		 CTD PMID:20493250 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Lovastatin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Lovastatin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Lovastatin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of UCP2 mRNA CTD PMID:29852127 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Lovastatin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711 		JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression		 ISO Lovastatin results in decreased expression of VCP mRNA
Lovastatin results in increased expression of VCP mRNA		 CTD PMID:20493250 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions
increases expression		 ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of WEE1 mRNA]
Lovastatin results in increased expression of WEE1 mRNA		 CTD PMID:22712078 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Lovastatin results in increased expression of XIAP mRNA CTD PMID:26739623 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Lovastatin results in increased expression of XPA mRNA CTD PMID:26739623 NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Lovastatin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression EXP Simvastatin results in decreased expression of A2M mRNA CTD PMID:16414398 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression		 ISO
EXP		 Simvastatin results in decreased expression of ABCA1; Simvastatin results in decreased expression of ABCA1 mRNA
Simvastatin results in increased expression of ABCA1 mRNA
Simvastatin results in increased expression of ABCA1 mRNA; Simvastatin results in increased expression of ABCA1 protein		 CTD PMID:16282522 PMID:18270459 PMID:19383813 PMID:19461118 PMID:21241519 More... NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 Simvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Simvastatin results in decreased activity of ABCB11 protein
Simvastatin results in decreased expression of ABCB11 mRNA		 CTD PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
decreases activity
increases transport		 ISO ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin]; Simvastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
ABCB1 polymorphism affects the susceptibility to Simvastatin
Simvastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Simvastatin		 CTD PMID:15616150 PMID:16321621 PMID:19802823 PMID:19891551 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression
decreases expression		 ISO
EXP		 Simvastatin results in increased expression of ABCB4 mRNA
Simvastatin results in decreased expression of ABCB4 mRNA		 CTD PMID:21241519 PMID:27765674 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases activity
affects response to substance
decreases expression		 EXP
ISO		 ABCC2 protein binds to and results in increased uptake of Simvastatin analog; Simvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Simvastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Simvastatin analog results in decreased activity of ABCC2 protein
ABCC2 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased expression of ABCC2 mRNA		 CTD PMID:15616150 PMID:22186618 PMID:23562342 PMID:27765674 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases nitrosation		 ISO artemisinin inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; parthenolide inhibits the reaction [Simvastatin results in increased nitrosation of ABCC3 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased nitrosation of ABCC3 protein] CTD PMID:18463201 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Simvastatin results in decreased expression of ABCG1 mRNA CTD PMID:19383813 PMID:22120639 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Simvastatin results in increased expression of ABCG5 mRNA CTD PMID:21241519 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Simvastatin results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression
multiple interactions		 EXP Simvastatin results in decreased expression of ACAA2 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of ACAA2 mRNA		 CTD PMID:25055962 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acacb acetyl-CoA carboxylase beta increases expression EXP Simvastatin results in increased expression of ACACB mRNA CTD PMID:12056585 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acan aggrecan multiple interactions
increases expression		 EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA] CTD PMID:18628692 PMID:19912653 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Simvastatin results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 Simvastatin results in decreased expression of ACTA2 protein
Simvastatin inhibits the reaction [TGFB1 results in increased expression of ACTA2 mRNA]		 CTD PMID:15677772 PMID:15855201 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actb actin, beta increases expression EXP Simvastatin results in increased expression of ACTB mRNA CTD PMID:25055962 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actn4 actinin alpha 4 increases expression ISO Simvastatin results in increased expression of ACTN4 mRNA CTD PMID:16710349 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP		 Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of ADIPOQ mRNA]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of ADIPOQ protein]
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]]; Simvastatin inhibits the reaction [Poloxamer results in decreased secretion of ADIPOQ protein]		 CTD PMID:17641834 PMID:29071762 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adora2b adenosine A2B receptor multiple interactions EXP Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of ADORA2B protein] CTD PMID:33774062 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression ISO Simvastatin results in increased expression of ADRB1 mRNA; Simvastatin results in increased expression of ADRB1 protein CTD PMID:19262002 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Afp alpha-fetoprotein increases expression ISO Simvastatin results in increased expression of AFP mRNA CTD PMID:10365819 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions
decreases expression		 ISO Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]
Simvastatin results in decreased expression of AGER protein		 CTD PMID:17038636 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression		 ISO
EXP		 [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT results in increased activity of RAC1 protein]; Simvastatin promotes the reaction [Glucose promotes the reaction [AGT protein results in increased expression of PTGS2 mRNA]]
Simvastatin results in decreased expression of AGT mRNA
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of PXN protein]]; Simvastatin inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of PXN protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]		 CTD PMID:17513949 PMID:18400235 PMID:18475152 PMID:19100119 PMID:19225232 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Simvastatin results in decreased expression of AGTR1 mRNA CTD PMID:17513949 PMID:18475152 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Simvastatin results in increased expression of AKR1C1 mRNA CTD PMID:17428261 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression ISO Simvastatin results in decreased expression of AKR1C3 mRNA CTD PMID:18192897 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression EXP Simvastatin results in decreased expression of AKR1D1 mRNA CTD PMID:25055962 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
decreases activity
increases phosphorylation
decreases phosphorylation		 ISO
EXP		 Simvastatin results in decreased expression of AKT1 mRNA; Simvastatin results in decreased expression of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; [Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA]; Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]
Simvastatin inhibits the reaction [Glucose results in decreased expression of AKT1 protein modified form]; Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein
Simvastatin results in decreased activity of AKT1 protein
Simvastatin results in increased phosphorylation of AKT1 protein
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]		 CTD PMID:12438947 PMID:17327694 PMID:17335931 PMID:18004065 PMID:18031796 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO Simvastatin results in increased expression of ALDH3A1 mRNA CTD PMID:17428261 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA CTD PMID:28263720 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Simvastatin results in increased expression of ALOX5AP mRNA CTD PMID:17183729 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Alpi alkaline phosphatase, intestinal increases expression ISO Simvastatin results in increased expression of ALPI mRNA CTD PMID:14973129 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
affects expression
multiple interactions		 ISO Simvastatin results in increased expression of ALPL mRNA
Simvastatin affects the expression of ALPL mRNA
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]		 CTD PMID:20417880 PMID:28975700 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Angpt1 angiopoietin 1 increases expression EXP Simvastatin results in increased expression of ANGPT1; Simvastatin results in increased expression of ANGPT1 mRNA; Simvastatin results in increased expression of ANGPT1 protein CTD PMID:18544044 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein] CTD PMID:20821229 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression EXP Simvastatin results in decreased expression of ANGPTL3 mRNA CTD PMID:25055962 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Simvastatin results in increased expression of ANGPTL4 mRNA CTD PMID:19262002 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Ankra2 ankyrin repeat family A member 2 increases expression EXP Simvastatin results in increased expression of ANKRA2 mRNA CTD PMID:25055962 NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730 		JBrowse link
G Anpep alanyl aminopeptidase, membrane increases expression ISO Simvastatin results in increased expression of ANPEP mRNA CTD PMID:19262002 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Anxa1 annexin A1 increases expression ISO Simvastatin results in increased expression of ANXA1 protein CTD PMID:14973129 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa3 annexin A3 decreases expression ISO Simvastatin results in decreased expression of ANXA3 mRNA
Simvastatin results in decreased expression of ANXA3 protein		 CTD PMID:14973129 PMID:17428261 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions ISO Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of AOC1 mRNA] CTD PMID:16373842 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP Simvastatin results in decreased expression of APMAP protein CTD PMID:20217863 NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 MTHFR gene mutant form inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]
Polystyrenes analog promotes the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Simvastatin promotes the reaction [Polystyrenes analog results in increased expression of APOA1 mRNA]
Simvastatin results in increased expression of APOA1 mRNA; Simvastatin results in increased expression of APOA1 protein
[Niacin co-treated with Ezetimibe co-treated with Simvastatin] results in increased expression of APOA1 protein; [Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]; Niacin promotes the reaction [[Simvastatin co-treated with Ezetimibe] results in increased expression of APOA1 protein]; Simvastatin results in increased expression of and results in increased secretion of APOA1 protein
Simvastatin results in decreased expression of APOA1 mRNA; Simvastatin results in decreased expression of APOA1 protein		 CTD PMID:8289597 PMID:8461338 PMID:12048122 PMID:12633795 PMID:18270459 More... NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP Simvastatin results in decreased expression of APOA2 mRNA CTD PMID:25055962 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]
Simvastatin results in increased expression of APOA4 protein
Polystyrenes analog promotes the reaction [Simvastatin results in decreased expression of APOA4 protein]; Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOA4 protein]
Simvastatin results in decreased expression of APOA4 mRNA; Simvastatin results in decreased expression of APOA4 protein		 CTD PMID:8289597 PMID:8461338 PMID:18224302 PMID:25055962 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apob apolipoprotein B multiple interactions
affects response to substance
decreases expression
decreases secretion		 ISO
EXP		 [LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB; [Niacin co-treated with Simvastatin] results in decreased expression of APOB protein; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]
APOB polymorphism affects the susceptibility to Simvastatin
Simvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOB protein]
Simvastatin results in decreased expression of APOB mRNA; Simvastatin results in decreased expression of APOB protein
Simvastatin results in decreased secretion of APOB protein		 CTD PMID:1627634 PMID:8289597 PMID:8461338 PMID:9512650 PMID:10498134 More... NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc1 apolipoprotein C1 decreases expression EXP Simvastatin results in decreased expression of APOC1 mRNA CTD PMID:25055962 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression EXP Simvastatin results in decreased expression of APOC3 mRNA CTD PMID:25055962 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoe apolipoprotein E decreases expression
affects response to substance
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of APOE; Simvastatin results in decreased expression of APOE mRNA
APOE affects the susceptibility to Simvastatin
Polystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein]
APOE polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased expression of APOE mRNA; Simvastatin results in decreased expression of APOE protein		 CTD PMID:8289597 PMID:8461338 PMID:11849659 PMID:11947894 PMID:12901521 More... NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Apof apolipoprotein F decreases expression EXP Simvastatin results in decreased expression of APOF mRNA CTD PMID:25055962 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946 		JBrowse link
G Apom apolipoprotein M decreases expression
increases expression
multiple interactions		 ISO Simvastatin results in decreased expression of APOM mRNA
Simvastatin results in increased expression of APOM mRNA; Simvastatin results in increased expression of APOM protein
T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; T0901317 inhibits the reaction [Simvastatin results in increased expression of APOM protein]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein]		 CTD PMID:21729290 PMID:22160096 NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases activity		 ISO
EXP		 oblimersen inhibits the reaction [Simvastatin results in decreased activity of APP protein alternative form]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein]		 CTD PMID:17241114 PMID:28734741 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Simvastatin results in decreased expression of ARHGAP29 mRNA CTD PMID:17428261 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028 		JBrowse link
G Arhgap4 Rho GTPase activating protein 4 increases expression ISO Simvastatin results in increased expression of ARHGAP4 mRNA CTD PMID:14630613 NCBI chr  X:151,636,071...151,651,528
Ensembl chr  X:151,632,454...151,651,128 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO Simvastatin results in increased expression of ARHGEF2 mRNA CTD PMID:14630613 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Simvastatin results in decreased expression of ASS1 mRNA CTD PMID:16414398 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation EXP Simvastatin results in increased phosphorylation of ATF2 protein CTD PMID:15488325 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Simvastatin results in increased expression of ATF3 mRNA CTD PMID:17428261 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf6 activating transcription factor 6 increases expression EXP Simvastatin results in increased expression of ATF6 mRNA; Simvastatin results in increased expression of ATF6 protein CTD PMID:18807172 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Simvastatin results in increased phosphorylation of and results in increased activity of ATM protein CTD PMID:20499237 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Simvastatin results in increased expression of ATP2A2 mRNA; Simvastatin results in increased expression of ATP2A2 protein CTD PMID:15916736 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression ISO Simvastatin results in increased expression of ATP6V1E1 mRNA CTD PMID:19262002 NCBI chr 4:154,022,358...154,044,486
Ensembl chr 4:154,022,358...154,044,584 		JBrowse link
G Aurka aurora kinase A decreases expression ISO Simvastatin results in decreased expression of AURKA mRNA CTD PMID:17428261 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Axin2 axin 2 affects expression EXP Simvastatin affects the expression of AXIN2 mRNA CTD PMID:19968183 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases expression ISO Simvastatin results in decreased expression of AXL mRNA CTD PMID:17428261 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]		 CTD PMID:12438947 PMID:27734117 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression		 ISO
EXP		 Simvastatin affects the localization of BAX protein
Simvastatin results in increased expression of BAX mRNA; Simvastatin results in increased expression of BAX protein		 CTD PMID:12557325 PMID:17901590 PMID:20045437 PMID:25300705 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
affects localization
increases expression		 ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]
Simvastatin affects the localization of BBC3 protein
Simvastatin results in increased expression of BBC3 mRNA; Simvastatin results in increased expression of BBC3 protein		 CTD PMID:17428261 PMID:20045437 PMID:21199873 PMID:37956312 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]
Simvastatin results in decreased expression of BCL2 mRNA; Simvastatin results in decreased expression of BCL2 protein
Simvastatin results in increased expression of BCL2 protein
Simvastatin results in increased expression of BCL2 mRNA; Simvastatin results in increased expression of BCL2 protein		 CTD PMID:17241114 PMID:17277159 PMID:17901590 PMID:18031796 PMID:18521906 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]
Simvastatin results in decreased expression of BCL2L1 protein		 CTD PMID:17277159 PMID:18521906 PMID:20060890 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions		 EXP Simvastatin results in increased expression of BDNF
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of BDNF mRNA]		 CTD PMID:18047562 PMID:20851742 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
increases secretion
multiple interactions		 ISO
EXP		 Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA
Simvastatin results in increased secretion of BGLAP protein
[Simvastatin co-treated with Dexamethasone] results in increased expression of BGLAP
Simvastatin results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]
Simvastatin results in increased expression of BGLAP; Simvastatin results in increased expression of BGLAP mRNA; Simvastatin results in increased expression of BGLAP protein		 CTD PMID:12914771 PMID:14601315 PMID:14973129 PMID:15953866 PMID:17252541 More... NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA CTD PMID:28263720 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions
decreases expression		 ISO Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]
Simvastatin results in decreased expression of BIRC2 protein		 CTD PMID:17277159 PMID:18521906 PMID:19343037 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:17277159 PMID:19343037 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein]
Simvastatin results in decreased expression of BIRC5 mRNA; Simvastatin results in decreased expression of BIRC5 protein		 CTD PMID:17277159 PMID:20464445 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp1 bone morphogenetic protein 1 increases expression EXP Simvastatin results in increased expression of BMP1 mRNA CTD PMID:12963647 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Simvastatin results in increased secretion of BMP2 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA]
Simvastatin results in increased expression of BMP2; Simvastatin results in increased expression of BMP2 mRNA
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; Simvastatin inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD1 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]]; Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD9 protein]]; Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]
Simvastatin results in increased expression of BMP2 mRNA; Simvastatin results in increased expression of BMP2 protein		 CTD PMID:10814523 PMID:11162604 PMID:12914771 PMID:16470222 PMID:17252541 More... NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 affects expression
increases expression
increases stability		 ISO Simvastatin affects the expression of BMPR2 mRNA
Simvastatin results in increased expression of BMPR2 protein
Simvastatin results in increased stability of BMPR2 mRNA		 CTD PMID:16297860 NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Simvastatin results in increased expression of BNIP3 mRNA CTD PMID:17428261 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression EXP Simvastatin results in decreased expression of C5AR1 mRNA CTD PMID:16414398 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
decreases expression		 EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1C protein]
Simvastatin results in decreased expression of CACNA1C mRNA; Simvastatin results in decreased expression of CACNA1C protein		 CTD PMID:19791473 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions
decreases expression		 EXP Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CACNA1H protein]
Simvastatin results in decreased expression of CACNA1H mRNA; Simvastatin results in decreased expression of CACNA1H protein		 CTD PMID:19791473 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Simvastatin inhibits the reaction [Oxygen deficiency results in decreased expression of CALB1 mRNA] CTD PMID:16373842 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Calb2 calbindin 2 decreases expression EXP Simvastatin results in decreased expression of CALB2 protein CTD PMID:20217863 NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438 		JBrowse link
G Cald1 caldesmon 1 decreases expression ISO Simvastatin results in decreased expression of CALD1 mRNA; Simvastatin results in decreased expression of CALD1 protein CTD PMID:14630613 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Calml3 calmodulin-like 3 increases expression ISO Simvastatin results in increased expression of CALML3 mRNA CTD PMID:17428261 NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175 		JBrowse link
G Capn1 calpain 1 increases expression ISO Simvastatin results in increased expression of CAPN1 mRNA CTD PMID:18664198 PMID:19253821 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 decreases expression EXP Simvastatin results in decreased expression of CAPZA1 protein CTD PMID:20217863 NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480 		JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 decreases expression EXP Simvastatin results in decreased expression of CAPZA2 protein CTD PMID:20217863 NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864 		JBrowse link
G Casp1 caspase 1 decreases activity
multiple interactions		 EXP Simvastatin results in decreased activity of CASP1 protein
Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CASP1 protein]		 CTD PMID:16054375 PMID:30408459 PMID:35762198 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Simvastatin results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19253821 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression
decreases activity		 ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [APP protein alternative form results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Coal Ash results in increased expression of CASP3 protein modified form]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein
[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein; [Lipopolysaccharides co-treated with Simvastatin] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; zinc protoporphyrin inhibits the reaction [[Glucose deficiency co-treated with Simvastatin] results in increased cleavage of CASP3 protein]
carvacrol inhibits the reaction [Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]]; PD 150606 inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]; Simvastatin promotes the reaction [Poloxamer results in increased expression of CASP3 protein]; Simvastatin results in decreased expression of and results in decreased activity of CASP3 protein; Simvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Verapamil inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]
Simvastatin results in increased expression of CASP3 mRNA; Simvastatin results in increased expression of CASP3 protein
Simvastatin results in decreased activity of CASP3 protein		 CTD PMID:11868908 PMID:12557325 PMID:12962723 PMID:14527821 PMID:15200425 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions ISO Simvastatin results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:19253821 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:19253821 PMID:20045437 PMID:20427495 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases cleavage		 ISO Simvastatin results in increased activity of CASP8 protein
Acetylcysteine inhibits the reaction [Simvastatin results in increased activity of CASP8 protein]
Simvastatin results in increased cleavage of CASP8 protein
Simvastatin results in increased cleavage of and results in increased activity of CASP8 protein		 CTD PMID:12962723 PMID:15705602 PMID:20464445 PMID:20883752 PMID:21910007 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
decreases activity
increases activity		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein]; Simvastatin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:12438947 PMID:12962723 PMID:15705602 PMID:16470222 PMID:19253821 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
increases activity
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of CAT mRNA
Simvastatin results in increased activity of CAT protein
carvacrol promotes the reaction [Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]]; Simvastatin inhibits the reaction [Diazepam results in decreased activity of CAT protein]; Simvastatin inhibits the reaction [Poloxamer results in decreased activity of CAT protein]		 CTD PMID:17479860 PMID:20883752 PMID:27111380 PMID:29071762 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 multiple interactions
decreases expression		 ISO
EXP		 Simvastatin inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA]
Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]
Simvastatin results in decreased expression of CAV1 protein
Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV1 protein]		 CTD PMID:16698853 PMID:18224302 PMID:19816600 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cav2 caveolin 2 multiple interactions EXP Simvastatin inhibits the reaction [[Semaxinib co-treated with Oxygen deficiency] results in decreased expression of CAV2 protein] CTD PMID:16698853 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244 		JBrowse link
G Cbs cystathionine beta synthase multiple interactions ISO Simvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]; Simvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein] CTD PMID:18224302 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases response to substance
affects expression		 ISO
EXP		 [Simvastatin co-treated with Ramipril] results in decreased expression of CCL2 protein; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL2 protein]; Simvastatin results in decreased expression of and results in decreased secretion of CCL2 protein
Simvastatin results in decreased expression of CCL2 mRNA; Simvastatin results in decreased expression of CCL2 protein
Simvastatin results in decreased susceptibility to CCL2 protein
Simvastatin affects the expression of CCL2 mRNA		 CTD PMID:12117737 PMID:12818400 PMID:15184351 PMID:15781755 PMID:15824212 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression EXP Simvastatin results in decreased expression of CCL20 mRNA CTD PMID:22305382 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO
EXP		 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]
Simvastatin results in decreased expression of CCL3 mRNA		 CTD PMID:16321392 PMID:16414398 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased secretion of CCL4 mRNA] CTD PMID:16321392 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
decreases expression		 ISO
EXP		 Simvastatin results in increased expression of CCL5 mRNA
Simvastatin results in decreased expression of CCL5 mRNA
Simvastatin results in decreased expression of CCL5 protein		 CTD PMID:17112859 PMID:17183729 PMID:17449418 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
decreases expression		 ISO Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]
Simvastatin results in decreased expression of CCN1 mRNA		 CTD PMID:17428261 PMID:20191585 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression		 ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 mRNA]; Simvastatin inhibits the reaction [Bleomycin results in increased expression of CCN2 protein]
Simvastatin inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein]
Simvastatin results in decreased expression of CCN2 mRNA; Simvastatin results in decreased expression of CCN2 protein		 CTD PMID:15200425 PMID:15298857 PMID:15677772 PMID:19080365 PMID:19099753 More... NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 decreases expression
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of CCNA2 mRNA
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein]		 CTD PMID:17428261 PMID:26577051 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO Simvastatin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
Simvastatin results in decreased expression of CCND1 mRNA; Simvastatin results in decreased expression of CCND1 protein		 CTD PMID:17277159 PMID:17428261 PMID:20878096 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases expression		 EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] CTD PMID:26577051 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions
decreases expression		 ISO
EXP		 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]
Simvastatin results in decreased expression of CCR1 mRNA		 CTD PMID:16321392 PMID:16414398 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions
decreases expression		 ISO
EXP		 [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 mRNA]; [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Simvastatin results in decreased expression of CCR2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]
Simvastatin results in decreased expression of CCR2 mRNA; Simvastatin results in decreased expression of CCR2 protein		 CTD PMID:15781755 PMID:16321392 PMID:16414398 PMID:16781696 PMID:17449418 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions ISO Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA] CTD PMID:16321392 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions
decreases expression		 ISO
EXP		 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]
Simvastatin results in decreased expression of CCR5 mRNA
Simvastatin results in decreased expression of CCR5 protein		 CTD PMID:16321392 PMID:17112859 PMID:17449418 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd14 CD14 molecule decreases expression EXP Simvastatin results in decreased expression of CD14 mRNA CTD PMID:16414398 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd151 CD151 molecule (Raph blood group) decreases expression EXP Simvastatin results in decreased expression of CD151 mRNA CTD PMID:16414398 NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753 		JBrowse link
G Cd24 CD24 molecule increases expression ISO Simvastatin results in increased expression of CD24 mRNA CTD PMID:18192897 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd27 CD27 molecule decreases expression ISO Simvastatin results in decreased expression of CD27 mRNA CTD PMID:18453621 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592 		JBrowse link
G Cd2ap CD2-associated protein increases expression ISO Simvastatin results in increased expression of CD2AP mRNA CTD PMID:16710349 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cd40 CD40 molecule decreases expression
multiple interactions		 ISO Simvastatin results in decreased expression of CD40 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]		 CTD PMID:16387846 PMID:17169357 PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand decreases expression
increases expression
multiple interactions		 ISO Simvastatin results in decreased expression of CD40LG protein; Simvastatin results in decreased expression of CD40LG protein modified form
Simvastatin results in increased expression of CD40LG protein
Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]]; Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]		 CTD PMID:17169357 PMID:18269829 PMID:21330348 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd44 CD44 molecule multiple interactions
decreases expression		 ISO Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein]; Simvastatin promotes the reaction [TP53 protein binds to CD44 promoter]
Simvastatin results in decreased expression of CD44 mRNA; Simvastatin results in decreased expression of CD44 protein		 CTD PMID:21199873 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd80 Cd80 molecule decreases expression EXP Simvastatin results in decreased expression of CD80 mRNA CTD PMID:22305382 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO Simvastatin results in decreased expression of CD83 protein CTD PMID:16387846 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule decreases expression ISO Simvastatin results in decreased expression of CD86 protein CTD PMID:16387846 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdc25b cell division cycle 25B affects expression ISO Simvastatin affects the expression of CDC25B mRNA; Simvastatin affects the expression of CDC25B protein CTD PMID:19110722 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc42 cell division cycle 42 decreases activity ISO Simvastatin results in decreased activity of CDC42 protein CTD PMID:17169357 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO Simvastatin results in decreased expression of CDC45 mRNA CTD PMID:17428261 NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Simvastatin results in decreased expression of CDC6 mRNA CTD PMID:17428261 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdh5 cadherin 5 increases expression EXP Simvastatin results in increased expression of CDH5 mRNA; Simvastatin results in increased expression of CDH5 protein CTD PMID:19109527 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of CDK1 mRNA; Simvastatin results in decreased expression of CDK1 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]		 CTD PMID:17428261 PMID:20878096 PMID:26577051 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 [Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in decreased activity of CDK2 protein
Simvastatin results in decreased expression of CDK2 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein]		 CTD PMID:10412745 PMID:17928568 PMID:18804536 PMID:20878096 PMID:26577051 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
decreases activity		 ISO
EXP		 Simvastatin results in decreased expression of CDK4 protein
Simvastatin results in decreased activity of CDK4 protein		 CTD PMID:18804536 PMID:20878096 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression ISO Simvastatin results in increased expression of CDK5 CTD PMID:19461118 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO
EXP		 [Simvastatin results in decreased degradation of CDKN1A protein] which results in decreased activity of CDK2 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein]; Simvastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein]
Simvastatin results in increased expression of CDKN1A mRNA; Simvastatin results in increased expression of CDKN1A protein		 CTD PMID:15625077 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18625202 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO
EXP		 [Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein
Simvastatin results in increased expression of CDKN1B mRNA; Simvastatin results in increased expression of CDKN1B protein		 CTD PMID:12963647 PMID:17428261 PMID:17928568 PMID:18337644 PMID:18804536 More... NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO Simvastatin results in increased expression of CDKN1C mRNA CTD PMID:17428261 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression EXP Simvastatin results in increased expression of CDKN2A protein CTD PMID:18804536 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D increases expression ISO Simvastatin results in increased expression of CDKN2D mRNA; Simvastatin results in increased expression of CDKN2D protein CTD PMID:20878096 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO Simvastatin results in decreased expression of CDT1 mRNA CTD PMID:17428261 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta multiple interactions ISO Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter] CTD PMID:16575855 NCBI chr 6:16,119,871...16,137,600
Ensembl chr 6:16,119,872...16,137,600 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions EXP
ISO		 Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 mRNA]; Simvastatin affects the reaction [Dietary Fats affects the expression of CES1 protein]
Simvastatin inhibits the reaction [CES1 protein results in increased hydrolysis of remdesivir]		 CTD PMID:33383043 PMID:34774545 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO Simvastatin inhibits the reaction [TNF protein results in increased expression of CFLAR protein]
Simvastatin results in decreased expression of CFLAR protein; Simvastatin results in decreased expression of CFLAR protein alternative form
Simvastatin results in increased expression of CFLAR mRNA; Simvastatin results in increased expression of CFLAR protein		 CTD PMID:17277159 PMID:18521906 PMID:19262002 PMID:21910007 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions EXP Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CFTR protein] CTD PMID:33774062 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA] CTD PMID:16828882 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA] CTD PMID:16828882 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
increases phosphorylation
increases expression		 ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of CHUK protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of CHUK protein]
Simvastatin results in increased expression of CHUK mRNA		 CTD PMID:18463201 PMID:19262002 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator multiple interactions ISO Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein] CTD PMID:11219190 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions
decreases expression
increases secretion		 ISO
EXP		 [Clarithromycin co-treated with Simvastatin] results in increased expression of CKM protein
Simvastatin results in decreased expression of CKM protein
carvacrol inhibits the reaction [Simvastatin results in increased secretion of CKM protein]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of CKM protein]		 CTD PMID:8611662 PMID:19252767 PMID:29071762 PMID:35762198 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 multiple interactions
decreases expression		 EXP Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]
Simvastatin results in decreased expression of CLCN3 protein		 CTD PMID:20644009 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Cldn18 claudin 18 multiple interactions EXP Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of CLDN18 protein] CTD PMID:33774062 NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351 		JBrowse link
G Cldn4 claudin 4 multiple interactions EXP Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CLDN4 protein] CTD PMID:33774062 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain increases expression ISO Simvastatin results in increased expression of COL11A1 mRNA CTD PMID:16274305 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression ISO Simvastatin results in increased expression of COL12A1 mRNA CTD PMID:16274305 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686 		JBrowse link
G Col13a1 collagen type XIII alpha 1 chain decreases response to substance ISO COL13A1 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr20:29,783,965...29,924,116
Ensembl chr20:29,783,965...29,924,032 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
increases expression		 ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA]; Simvastatin inhibits the reaction [CEBPZ binds to COL1A1 promoter]; Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter]
Simvastatin results in increased expression of COL1A1 mRNA		 CTD PMID:10412775 PMID:14973129 PMID:16274305 PMID:16575855 PMID:17252541 More... NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions
increases expression		 EXP Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA]; NOG inhibits the reaction [Simvastatin results in increased expression of COL2A1 mRNA] CTD PMID:18628692 PMID:19912653 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
decreases expression		 ISO
EXP		 Simvastatin results in increased expression of COL3A1 mRNA
Simvastatin results in decreased expression of COL3A1 mRNA		 CTD PMID:10412775 PMID:16274305 PMID:16414398 PMID:17183729 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO Simvastatin results in decreased expression of COL4A1 mRNA CTD PMID:10412775 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Col5a1 collagen type V alpha 1 chain increases expression ISO Simvastatin results in increased expression of COL5A1 mRNA CTD PMID:16274305 NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Simvastatin results in increased expression of COL6A2 mRNA CTD PMID:16274305 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564 		JBrowse link
G Col7a1 collagen type VII alpha 1 chain increases expression ISO Simvastatin results in increased expression of COL7A1 mRNA CTD PMID:17428261 NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252 		JBrowse link
G Coro1a coronin 1A decreases expression EXP Simvastatin results in decreased expression of CORO1A protein CTD PMID:20217863 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Simvastatin inhibits the reaction [OSM results in increased phosphorylation of CREB1 protein] CTD PMID:20191585 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions		 ISO Simvastatin results in decreased expression of CRP protein
[Ezetimibe co-treated with Simvastatin] results in decreased expression of CRP protein; [Simvastatin co-treated with Ezetimibe] promotes the reaction [Niacin results in decreased expression of CRP protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]]; Simvastatin inhibits the reaction [[Ethinyl Estradiol co-treated with Desogestrel] results in increased expression of CRP protein]; Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]; Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]; Simvastatin inhibits the reaction [ethinyl estradiol-desogestrel combination results in increased expression of CRP protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CRP protein]		 CTD PMID:15184351 PMID:15824212 PMID:17105841 PMID:18023360 PMID:18420099 More... NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cs citrate synthase multiple interactions
increases activity		 EXP [Simvastatin co-treated with Lipopolysaccharides] results in increased activity of CS protein
Simvastatin results in increased activity of CS protein		 CTD PMID:25674200 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 increases expression ISO Simvastatin results in increased expression of CSPG4 mRNA CTD PMID:19262002 NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of AGT mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of NPPA mRNA]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of JAK2 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein] CTD PMID:16534557 PMID:18400235 PMID:19100119 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 decreases expression ISO Simvastatin results in decreased expression of CTLA4 mRNA CTD PMID:18453621 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Ctnnal1 catenin alpha-like 1 decreases expression ISO Simvastatin results in decreased expression of CTNNAL1 mRNA CTD PMID:17428261 NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 ISO
EXP		 CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Simvastatin results in increased expression of SP7 protein]
Simvastatin inhibits the reaction [Glucose results in decreased expression of CTNNB1 protein]
Simvastatin results in increased expression of CTNNB1 protein		 CTD PMID:18004065 PMID:22058016 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsl cathepsin L increases expression EXP Simvastatin results in increased expression of CTSL mRNA CTD PMID:19001041 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S multiple interactions ISO Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS mRNA]; Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of CTSS protein] CTD PMID:20835264 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cttn cortactin affects localization
multiple interactions		 ISO Simvastatin affects the localization of CTTN protein
Simvastatin affects the reaction [F2 affects the localization of CTTN protein]		 CTD PMID:14630613 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 decreases expression ISO Simvastatin results in decreased expression of CX3CR1 mRNA CTD PMID:18359719 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression		 ISO
EXP		 Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL10 mRNA]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL10 protein]
Simvastatin results in decreased expression of CXCL10 mRNA; Simvastatin results in decreased expression of CXCL10 protein		 CTD PMID:15187114 PMID:16414398 PMID:17449418 PMID:22305382 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Simvastatin results in increased expression of CXCL12 CTD PMID:19591934 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 decreases expression EXP Simvastatin results in decreased expression of CXCL16 mRNA CTD PMID:25055962 NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Simvastatin results in decreased expression of CXCL2 mRNA; Simvastatin results in decreased expression of CXCL2 protein CTD PMID:21330348 PMID:21441352 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Simvastatin results in decreased expression of CXCL1 mRNA; Simvastatin results in decreased expression of CXCL1 protein CTD PMID:21330348 PMID:21441352 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression EXP Simvastatin results in decreased expression of CXCL5 mRNA CTD PMID:16414398 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression EXP Simvastatin results in decreased expression of CXCR2 mRNA CTD PMID:16414398 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
increases expression		 EXP Simvastatin results in decreased expression of CXCR4 mRNA
Simvastatin results in increased expression of CXCR4		 CTD PMID:16414398 PMID:19591934 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyba cytochrome b-245 alpha chain affects response to substance ISO CYBA gene SNP affects the susceptibility to Simvastatin CTD PMID:15936011 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Simvastatin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein] CTD PMID:30513525 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11A1 mRNA; [Simvastatin co-treated with resveratrol] results in decreased expression of CYP11A1 mRNA CTD PMID:24524197 PMID:25055962 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B1 mRNA CTD PMID:25055962 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP11B2 mRNA CTD PMID:25055962 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions		 EXP Simvastatin results in decreased expression of CYP17A1 mRNA
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of CYP17A1 mRNA; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; resveratrol promotes the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA]; Simvastatin promotes the reaction [resveratrol results in decreased expression of CYP17A1 mRNA]		 CTD PMID:21918126 PMID:24524197 PMID:25055962 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Simvastatin results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Simvastatin results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP27A1 mRNA] CTD PMID:33383043 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Simvastatin results in increased expression of CYP2B6 mRNA CTD PMID:15802384 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Simvastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance ISO CYP2D6 polymorphism affects the susceptibility to Simvastatin CTD PMID:11753271 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 decreases expression EXP Simvastatin results in decreased expression of CYP39A1 mRNA CTD PMID:25055962 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
decreases expression
affects metabolic processing
increases expression
increases metabolic processing
affects response to substance		 EXP
ISO		 Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
Simvastatin results in decreased expression of CYP3A4 mRNA; Simvastatin results in decreased expression of CYP3A4 protein
CYP3A4 protein affects the metabolism of Simvastatin
Simvastatin results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased metabolism of Simvastatin
[Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Simvastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Simvastatin]; telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin]		 CTD PMID:12505310 PMID:15650881 PMID:16011971 PMID:17041008 PMID:19802823 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 polymorphism affects the susceptibility to Simvastatin CTD PMID:17192506 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 decreases expression EXP Simvastatin results in decreased expression of CYP46A1 mRNA CTD PMID:25055962 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Simvastatin results in increased expression of CYP51 mRNA CTD PMID:25055962 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 mRNA]; Simvastatin promotes the reaction [Dietary Fats results in increased expression of CYP7A1 protein] CTD PMID:33383043 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit decreases expression ISO Simvastatin results in decreased expression of DBF4 mRNA CTD PMID:17428261 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066 		JBrowse link
G Dbp D-box binding PAR bZIP transcription factor multiple interactions ISO Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of DBP mRNA] CTD PMID:16373842 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745 		JBrowse link
G Dcx doublecortin increases expression EXP Simvastatin results in increased expression of DCX CTD PMID:18544044 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 decreases expression EXP Simvastatin results in decreased expression of DDAH1 mRNA CTD PMID:16414398 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression
increases activity		 EXP Simvastatin results in increased expression of DGAT1 mRNA
Simvastatin results in increased activity of DGAT1 protein		 CTD PMID:12056585 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO
EXP		 Simvastatin results in increased expression of DHCR24
Simvastatin results in increased expression of DHCR24 mRNA; Simvastatin results in increased expression of DHCR24 protein		 CTD PMID:21987590 PMID:25055962 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects response to substance
multiple interactions
affects expression		 ISO
EXP		 DHCR7 mutant form affects the susceptibility to Simvastatin
Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]; Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA		 CTD PMID:15896653 PMID:16446309 PMID:19365639 PMID:25055962 PMID:28975700 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions		 ISO Simvastatin affects the localization of DIABLO protein
DIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]		 CTD PMID:20045437 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 inhibits the reaction [Simvastatin results in increased expression of BGLAP mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of RUNX2 mRNA]; DKK1 inhibits the reaction [Simvastatin results in increased expression of SP7 mRNA] CTD PMID:22058016 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 increases expression EXP Simvastatin results in increased expression of DLL4 mRNA CTD PMID:19109527 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dnm1l dynamin 1-like affects localization
increases expression		 ISO Simvastatin affects the localization of DNM1L protein
Simvastatin results in increased expression of DNM1L protein		 CTD PMID:20045437 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
increases expression		 EXP SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]; SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]; Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]; Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]
Simvastatin results in increased expression of DRD1 mRNA; Simvastatin results in increased expression of DRD1 protein		 CTD PMID:15711596 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Simvastatin results in increased expression of DRD2 mRNA; Simvastatin results in increased expression of DRD2 protein CTD PMID:15711596 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dspp dentin sialophosphoprotein increases expression ISO Simvastatin results in increased expression of DSPP mRNA CTD PMID:19249597 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672 		JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Simvastatin results in decreased expression of DUSP1 mRNA; Simvastatin results in decreased expression of DUSP1 protein CTD PMID:21080865 NCBI chr10:16,680,478...16,683,275 JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Simvastatin results in decreased expression of E2F1 mRNA CTD PMID:17428261 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Simvastatin CTD PMID:21483694 NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610 		JBrowse link
G Edn1 endothelin 1 decreases secretion
multiple interactions
decreases expression		 ISO
EXP		 Simvastatin results in decreased secretion of EDN1 protein
Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
Simvastatin results in decreased expression of EDN1 mRNA; Simvastatin results in decreased expression of EDN1 protein
Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]; Simvastatin results in increased expression of and results in increased secretion of EDN1 protein		 CTD PMID:16375908 PMID:18390205 PMID:19099753 PMID:20369390 PMID:20644009 More... NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA mRNA]; Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA] CTD PMID:19505368 PMID:22022327 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein] CTD PMID:20359552 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO Simvastatin results in decreased expression of EGR1 protein CTD PMID:12818400 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO Simvastatin results in decreased phosphorylation of EIF4EBP1 protein
IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:22144680 PMID:27734117 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eno1 enolase 1 decreases expression EXP Simvastatin results in decreased expression of ENO1 protein CTD PMID:20217863 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions ISO Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Epha3 Eph receptor A3 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA CTD PMID:28263720 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Epha8 Eph receptor A8 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA CTD PMID:28263720 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399 		JBrowse link
G Epo erythropoietin multiple interactions EXP Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA] CTD PMID:20821229 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Epor erythropoietin receptor multiple interactions EXP Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA] CTD PMID:20821229 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity		 ISO Cycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]; Simvastatin affects the reaction [F2 affects the localization of CTTN protein]; Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 PMID:14630613 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
increases expression
affects response to substance
decreases activity		 ISO geranylgeraniol inhibits the reaction [Simvastatin results in decreased expression of F3]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]
Simvastatin results in decreased expression of F3; Simvastatin results in decreased expression of F3 mRNA; Simvastatin results in decreased expression of F3 protein
Simvastatin results in increased expression of F3 mRNA; Simvastatin results in increased expression of F3 protein
F3 polymorphism affects the susceptibility to Simvastatin
Simvastatin results in decreased activity of F3 protein		 CTD PMID:9081680 PMID:10830219 PMID:12753293 PMID:12818400 PMID:15824212 More... NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fasn fatty acid synthase increases expression ISO
EXP		 Simvastatin results in increased expression of FASN mRNA CTD PMID:11728391 PMID:12056585 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions		 ISO
EXP		 Simvastatin results in increased expression of FBXO32 mRNA; Simvastatin results in increased expression of FBXO32 protein
FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]		 CTD PMID:19001041 PMID:25300705 PMID:27734117 PMID:33034787 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression
increases activity
multiple interactions		 EXP
ISO		 Simvastatin results in increased expression of FDFT1 protein
Simvastatin results in increased activity of FDFT1 protein
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDFT1 mRNA]		 CTD PMID:8517861 PMID:12518039 PMID:23386644 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase increases expression
multiple interactions		 ISO Simvastatin results in increased expression of FDPS mRNA
resveratrol inhibits the reaction [Simvastatin results in increased expression of FDPS mRNA]		 CTD PMID:23386644 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions EXP Simvastatin inhibits the reaction [Dietary Fats results in increased expression of FGF19 mRNA] CTD PMID:33383043 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Simvastatin results in increased expression of FGF2 CTD PMID:20381859 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Simvastatin results in decreased expression of FKBP1A mRNA CTD PMID:16414398 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 increases expression ISO Simvastatin results in increased expression of FKBP4 mRNA CTD PMID:19262002 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833 		JBrowse link
G Flot1 flotillin 1 decreases expression ISO Simvastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression		 EXP Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]
Simvastatin results in increased expression of FLT1 mRNA		 CTD PMID:19109527 PMID:20821229 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression		 ISO
EXP		 Simvastatin results in decreased expression of FN1 mRNA
Simvastatin results in increased expression of FN1 mRNA		 CTD PMID:10412775 PMID:15855201 PMID:16274305 PMID:16414398 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases localization
decreases expression		 ISO
EXP		 farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA]
Simvastatin results in decreased localization of FOS protein
FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FOS protein]
Simvastatin inhibits the reaction [CTF1 results in increased expression of FOS mRNA]		 CTD PMID:12753293 PMID:12963647 PMID:15187114 PMID:16005304 PMID:19100119 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]] CTD PMID:15187114 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Simvastatin results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions ISO Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]] CTD PMID:15187114 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Foxo1 forkhead box O1 affects localization
decreases phosphorylation
increases phosphorylation
multiple interactions
decreases localization		 EXP
ISO		 Simvastatin affects the localization of FOXO1 protein
Simvastatin results in decreased phosphorylation of FOXO1 protein
Simvastatin results in increased phosphorylation of FOXO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein]		 CTD PMID:12438947 PMID:18826357 PMID:19001041 PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
affects localization		 ISO
EXP		 Acetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]
Simvastatin results in decreased expression of FOXO3 protein
Simvastatin results in decreased phosphorylation of FOXO3 protein		 CTD PMID:19001041 PMID:20883752 PMID:27734117 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxp3 forkhead box P3 increases expression
multiple interactions
affects methylation
decreases expression		 ISO
EXP		 Simvastatin results in increased expression of FOXP3
IL2 affects the reaction [Simvastatin results in increased expression of FOXP3]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of FOXP3]
Simvastatin affects the methylation of FOXP3 promoter
Simvastatin results in decreased expression of FOXP3 mRNA		 CTD PMID:20408897 PMID:20491794 PMID:22305382 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Fst follistatin multiple interactions ISO FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of MTOR protein]; FST protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD2 protein]; FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein] CTD PMID:33034787 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Fzd2 frizzled class receptor 2 increases expression EXP Simvastatin results in increased expression of FZD2 mRNA CTD PMID:19968183 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Simvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA CTD PMID:24204015 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Simvastatin results in decreased expression of GAPDH mRNA CTD PMID:16414398 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gata6 GATA binding protein 6 increases expression EXP Simvastatin results in increased expression of GATA6 mRNA; Simvastatin results in increased expression of GATA6 protein CTD PMID:19842842 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression EXP Simvastatin results in decreased expression of GDI2 protein CTD PMID:20217863 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Simvastatin results in increased expression of GDNF CTD PMID:20851742 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA CTD PMID:28263720 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Simvastatin affects the localization of and results in decreased phosphorylation of GJA1 protein CTD PMID:23978459 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression ISO Simvastatin results in increased expression of GJB2 mRNA CTD PMID:17428261 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Simvastatin inhibits the reaction [Coal Ash results in increased expression of GLB1 protein] CTD PMID:26773838 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of GPX1 mRNA
Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]		 CTD PMID:20883752 PMID:28734741 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Simvastatin results in increased expression of GPX2 mRNA CTD PMID:18787804 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions		 ISO
EXP		 Simvastatin results in increased expression of GSK3B
Simvastatin inhibits the reaction [Glucose results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of GSK3B protein]
Simvastatin results in increased expression of GSK3B protein modified form		 CTD PMID:18004065 PMID:18047562 PMID:19461118 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Simvastatin inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Simvastatin results in increased phosphorylation of H2AX protein CTD PMID:20499237 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 increases expression EXP Simvastatin results in increased expression of HES5 mRNA CTD PMID:19109527 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
decreases expression		 ISO
EXP		 Simvastatin results in increased expression of HIF1A protein
HIF1A mutant form inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA]
Simvastatin results in decreased expression of HIF1A mRNA		 CTD PMID:18356691 PMID:21844074 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO		 Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]
[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]		 CTD PMID:20519084 PMID:25412314 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases response to substance
affects response to substance
increases activity
multiple interactions
increases expression
decreases activity		 ISO
EXP		 HMGCR exon alternative form results in decreased susceptibility to Simvastatin
HMGCR intron polymorphism affects the susceptibility to Simvastatin; HMGCR polymorphism affects the susceptibility to Simvastatin
Simvastatin results in increased activity of HMGCR protein
[HMGCR intron polymorphism affects the expression of HMGCR exon alternative form] which results in decreased susceptibility to Simvastatin; [MVK gene mutant form results in increased activity of HMGCR protein] which results in increased susceptibility to Simvastatin; [Simvastatin co-treated with Ezetimibe] results in increased expression of HMGCR mRNA; HMGCR polymorphism promotes the reaction [[LDLR 3' UTR polymorphism affects the susceptibility to Simvastatin] which affects the expression of APOB]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; Resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
Colesevelam Hydrochloride promotes the reaction [Simvastatin results in increased expression of HMGCR mRNA]
Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of HMGCR protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR mRNA]; resveratrol inhibits the reaction [Simvastatin results in increased expression of HMGCR protein]; resveratrol promotes the reaction [Simvastatin results in decreased activity of HMGCR protein]; Simvastatin results in increased expression of and results in decreased activity of HMGCR protein; Simvastatin results in increased expression of and results in increased activity of HMGCR protein
Simvastatin results in increased expression of HMGCR mRNA; Simvastatin results in increased expression of HMGCR protein		 CTD PMID:1627634 PMID:8517861 PMID:8593127 PMID:9512650 PMID:10357840 More... NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases stability
decreases expression
increases activity
increases expression
increases response to substance		 ISO
EXP		 [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 protein]]
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; tin protoporphyrin IX inhibits the reaction [Simvastatin results in increased expression of HMOX1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased stability of HMOX1 mRNA]; MAPK1 promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]
Simvastatin results in decreased expression of HMOX1 mRNA
Simvastatin results in increased activity of HMOX1 protein
Simvastatin results in increased expression of HMOX1 mRNA; Simvastatin results in increased expression of HMOX1 protein
HMOX1 gene mutant form results in increased susceptibility to Simvastatin		 CTD PMID:16375908 PMID:16414398 PMID:16628357 PMID:17928392 PMID:18073186 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A increases expression ISO Simvastatin results in increased expression of HNF1A mRNA CTD PMID:22160096 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
decreases activity		 ISO Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; MVK gene mutant form promotes the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased prenylation of HRAS protein]; Simvastatin results in decreased prenylation of and results in decreased localization of HRAS protein
Simvastatin results in decreased activity of HRAS		 CTD PMID:11914545 PMID:12477733 PMID:18625914 PMID:19360310 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP [Simvastatin co-treated with resveratrol] results in decreased expression of HSD3B1 mRNA CTD PMID:24524197 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsf1 heat shock transcription factor 1 affects localization ISO Simvastatin affects the localization of HSF1 protein CTD PMID:16375908 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression ISO Simvastatin results in increased expression of HSP90AA1 protein CTD PMID:16375908 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Simvastatin results in increased expression of HSPA4 protein CTD PMID:16375908 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Simvastatin results in increased expression of HSPA5 mRNA; Simvastatin results in increased expression of HSPA5 protein CTD PMID:18664198 PMID:19253821 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Simvastatin results in decreased expression of HSPA8 protein CTD PMID:20217863 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Htra2 HtrA serine peptidase 2 affects localization ISO Simvastatin affects the localization of HTRA2 protein CTD PMID:20045437 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ibsp integrin-binding sialoprotein increases expression ISO Simvastatin results in increased expression of IBSP mRNA CTD PMID:20417880 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO
EXP		 farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Simvastatin affects the expression of and affects the secretion of ICAM1 protein; Simvastatin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Vitamin E inhibits the reaction [Simvastatin results in decreased expression of ICAM1 protein modified form]
Simvastatin results in decreased expression of ICAM1 mRNA; Simvastatin results in decreased expression of ICAM1 protein; Simvastatin results in decreased expression of ICAM1 protein modified form		 CTD PMID:10946302 PMID:12615677 PMID:14602771 PMID:15234187 PMID:16054375 More... NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO Simvastatin results in increased expression of ID1 mRNA CTD PMID:19262002 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Simvastatin results in increased expression of IDI1 mRNA CTD PMID:25055962 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO Simvastatin results in increased expression of IDO1 CTD PMID:20491794 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
increases secretion		 ISO IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of PTGS2]; Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL2 protein]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL3 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased secretion of CCL4 mRNA]
Simvastatin results in increased expression of IFNG mRNA
Simvastatin results in increased secretion of IFNG protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]]; Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]; Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA]; Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]; Simvastatin promotes the reaction [IFNG promotes the reaction [RELA binds to CD40 promoter]]; Simvastatin promotes the reaction [IFNG results in increased expression of PTGS2]		 CTD PMID:11219190 PMID:16321392 PMID:17507688 PMID:18453621 PMID:19589242 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of EIF4EBP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6 protein]; IGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of RPS6KB1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of CASP3 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of TRIM63 mRNA]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of AKT1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK1 protein]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein] CTD PMID:17327694 PMID:27734117 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
increases expression
multiple interactions		 ISO Simvastatin results in decreased expression of IGF1R; Simvastatin results in decreased expression of IGF1R mRNA; Simvastatin results in decreased expression of IGF1R protein
Simvastatin results in increased expression of IGF1R protein alternative form
[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]		 CTD PMID:17158816 PMID:17327694 PMID:18489904 PMID:27734117 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression ISO Simvastatin results in increased expression of IGFBP6 mRNA CTD PMID:17428261 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases expression
increases phosphorylation		 ISO artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; parthenolide inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]; Simvastatin promotes the reaction [Doxorubicin results in increased phosphorylation of IKBKB protein]
Simvastatin results in decreased expression of IKBKB mRNA		 CTD PMID:17277159 PMID:18463201 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 ISO
EXP		 Simvastatin results in increased expression of IL10
Simvastatin results in increased expression of IL10 mRNA; Simvastatin results in increased expression of IL10 protein
Simvastatin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]]; [Lipopolysaccharides co-treated with Simvastatin] results in increased expression of and results in increased secretion of IL10 protein; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of IL10 protein]		 CTD PMID:15883752 PMID:20491794 PMID:21925249 PMID:25674200 PMID:33774062 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; JUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein]; Simvastatin promotes the reaction [Pam(3)CSK(4) peptide results in increased expression of IL12B protein]; Simvastatin promotes the reaction [resiquimod results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Simvastatin results in decreased expression of IL13 mRNA; Simvastatin results in decreased expression of IL13 protein CTD PMID:17169357 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il16 interleukin 16 multiple interactions ISO [Lipopolysaccharides co-treated with Simvastatin] results in increased expression of IL16 mRNA CTD PMID:15665042 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il17a interleukin 17A multiple interactions
decreases expression
decreases secretion		 ISO IFNG affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IFNG affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] CTD PMID:18453621 PMID:21856936 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il17f interleukin 17F decreases secretion ISO Simvastatin results in decreased secretion of IL17F protein CTD PMID:21856936 NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP
ISO		 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]
Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]		 CTD PMID:18660453 PMID:27377765 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NFKBIA protein modified form]; Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]; Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]; Simvastatin inhibits the reaction [IL1A results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [IL1A results in increased localization of RELA protein]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]		 CTD PMID:15705589 PMID:15728660 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases secretion		 EXP
ISO		 1-propyl-8-(4-sulfophenyl)xanthine inhibits the reaction [Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; Nitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B mRNA]; Simvastatin affects the reaction [Doxorubicin results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Simvastatin inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]]; Simvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [IL1B protein results in increased activity of MMP9 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL1B protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE mRNA]; Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; Simvastatin promotes the reaction [IL1B protein results in increased expression of VCAM1 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Simvastatin results in decreased expression of IL1B mRNA; Simvastatin results in decreased expression of IL1B protein
Simvastatin results in decreased secretion of IL1B protein		 CTD PMID:10946302 PMID:12829860 PMID:15883752 PMID:16054375 PMID:17075836 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 decreases expression EXP Simvastatin results in decreased expression of IL1R2 mRNA CTD PMID:16414398 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression EXP Simvastatin results in decreased expression of IL1RL1 mRNA CTD PMID:16414398 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO IL2 affects the reaction [Simvastatin results in increased expression of FOXP3] CTD PMID:20408897 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta increases expression ISO Simvastatin results in increased expression of IL20RB mRNA CTD PMID:17428261 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Il21 interleukin 21 decreases expression
decreases secretion		 ISO Simvastatin results in decreased expression of IL21 mRNA
Simvastatin results in decreased secretion of IL21 protein		 CTD PMID:18453621 PMID:21856936 NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il22 interleukin 22 decreases secretion ISO Simvastatin results in decreased secretion of IL22 protein CTD PMID:21856936 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186 		JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO
EXP		 Simvastatin results in decreased expression of IL23A mRNA CTD PMID:18453621 PMID:22305382 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il25 interleukin 25 decreases expression EXP Simvastatin results in decreased expression of IL25 mRNA CTD PMID:22305382 NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893 		JBrowse link
G Il27 interleukin 27 increases expression
multiple interactions
increases secretion		 ISO Simvastatin results in increased expression of IL27 mRNA
IL27 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL27 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL27 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]
Simvastatin results in increased secretion of IL27 protein		 CTD PMID:18453621 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha affects expression
decreases expression		 ISO Simvastatin affects the expression of IL2RA protein
Simvastatin results in decreased expression of IL2RA mRNA		 CTD PMID:16387846 PMID:18453621 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
decreases expression		 ISO IL4 affects the reaction [Simvastatin results in decreased expression of IL17A mRNA]; IL4 affects the reaction [Simvastatin results in decreased expression of RORC mRNA]; IL4 affects the reaction [Simvastatin results in decreased secretion of IL17A protein]
Simvastatin results in increased expression of IL4 mRNA
Simvastatin results in increased secretion of IL4 protein
Simvastatin results in decreased expression of IL4 mRNA; Simvastatin results in decreased expression of IL4 protein		 CTD PMID:17169357 PMID:18453621 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO
EXP		 Simvastatin results in decreased expression of IL4R mRNA
Simvastatin results in decreased expression of IL4RA mRNA		 CTD PMID:16414398 PMID:18453621 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
decreases secretion
affects secretion		 ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]; Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [TNF results in increased localization of IL6 protein]; Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]; Simvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Simvastatin results in decreased expression of and results in decreased secretion of IL6 protein
Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]
Simvastatin results in increased expression of IL6 mRNA
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Simvastatin results in decreased expression of IL6 mRNA; Simvastatin results in decreased expression of IL6 protein
Simvastatin results in decreased secretion of IL6 protein
Simvastatin affects the secretion of IL6 protein		 CTD PMID:12117737 PMID:15665042 PMID:15883752 PMID:16387846 PMID:16424782 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inha inhibin subunit alpha multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INHA mRNA CTD PMID:25055962 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Insig2 insulin induced gene 2 decreases expression EXP Simvastatin results in decreased expression of INSIG2 mRNA CTD PMID:25055962 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Insl3 insulin-like 3 multiple interactions EXP [Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of INSL3 mRNA CTD PMID:25055962 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Simvastatin inhibits the reaction [IFNG results in increased expression of IRF1 mRNA] CTD PMID:17507688 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression
multiple interactions		 ISO Simvastatin results in decreased expression of IRF4 protein
Simvastatin results in decreased expression of IRF4 mRNA; Simvastatin results in decreased expression of IRF4 protein
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; IRF4 protein inhibits the reaction [Simvastatin results in increased expression of MSTN protein]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein]		 CTD PMID:21856936 PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IRS1 protein] CTD PMID:27734117 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Itgal integrin subunit alpha L affects binding
multiple interactions
decreases expression		 ISO Simvastatin binds to [ITGAL protein binds to ITGB2 protein]
Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]
Simvastatin results in decreased expression of ITGAL mRNA		 CTD PMID:12615677 PMID:15041742 PMID:16828882 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M decreases expression
multiple interactions		 ISO
EXP		 Simvastatin results in decreased expression of ITGAM mRNA; Simvastatin results in decreased expression of ITGAM protein
Simvastatin results in decreased expression of [ITGAM protein binds to ITGB2 protein]		 CTD PMID:16414398 PMID:21330348 PMID:21441352 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO