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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fenamic acid
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Accession:CHEBI:34756 term browser browse the term
Definition:An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.
Synonyms:exact_synonym: 2-(phenylamino)benzoic acid
 related_synonym: 2-anilinobenzoic acid;   2-carboxydiphenylamine;   DPC;   Diphenylamine-2-carboxylic acid;   Formula=C13H11NO2;   InChI=1S/C13H11NO2/c15-13(16)11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9,14H,(H,15,16);   InChIKey=ZWJINEZUASEZBH-UHFFFAOYSA-N;   N-phenyl-ortho-aminobenzoic acid;   N-phenylanthranilic acid;   SMILES=OC(=O)c1ccccc1Nc1ccccc1;   ortho-anilinobenzoic acid;   phenylanthranilic acid
 xref: CAS:91-40-7;   KEGG:C13697;   LINCS:LSM-6670
 xref_mesh: MESH:C001209
 xref: PMID:18970610;   PMID:20049895;   PMID:20183850;   PMID:21123756;   PMID:22301952;   Patent:US5212189;   Reaxys:1456607;   Wikipedia:Fenamic_acid


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fenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to fenamic acid CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO fenamic acid analog results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity		 ISO
EXP		 fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]
fenamic acid results in decreased activity of CFTR protein		 CTD PMID:14502435 PMID:14668136 PMID:15020588 PMID:15277574 PMID:15857825 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP fenamic acid results in increased expression of HAVCR1 mRNA CTD PMID:23142791 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Krt14 keratin 14 increases expression EXP fenamic acid results in increased expression of KRT14 mRNA CTD PMID:23142791 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP fenamic acid results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Mir210 microRNA 210 affects expression EXP fenamic acid affects the expression of MIR210 CTD PMID:30169741 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir34c microRNA 34c increases expression EXP fenamic acid results in increased expression of MIR34C CTD PMID:33367795 NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP fenamic acid results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fenamic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:10783394 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO fenamic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biophysical role 14048
          membrane transport modulator 13884
            fenamic acid 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          aromatic amino acid 3832
                                            aminobenzoic acid 1646
                                              anthranilic acid 1511
                                                fenamic acid 14
paths to the root